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Conserved domains on  [gi|1418308718|ref|XP_025282434|]
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cadherin-1 [Canis lupus dingo]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 159-259 6.42e-41

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


:

Pssm-ID: 206635  Cd Length: 98  Bit Score: 145.18  E-value: 6.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 159 IPPISCPENEKGPfpKNLVQIKSNRDKEIKVFYSITGQGADAPPvGVFIIERETGWLKVTEPLDREQIAKYILYSHAVSS 238
Cdd:cd00031     1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                          90       100
                  ....*....|....*....|.
gi 1418308718 239 NGNAVEDPMEIVITVTDQNDN 259
Cdd:cd00031    78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-120 4.05e-39

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 462590  Cd Length: 90  Bit Score: 139.77  E-value: 4.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718  31 PCRPGFGADSYTFTVPRRhLERGRVLGRVSFEGCTGLPRTAYVSDDTRFKVGTDGVITVKRPLQLHKPEISFLVHAWDSS 110
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRR-LEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 1418308718 111 -RRKLSTRVRL 120
Cdd:pfam08758  80 gEKMASVKVTV 90
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 820-879 8.14e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.69  E-value: 8.14e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 820 ADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 879
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 493-592 5.33e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 5.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 493 VVSIPEDFGVGQEITSYTAEDPDTYMEQRITYRIWR-DAAGWLEVNPESGAIFTRAELDREdfehvKNSTYEALIIAIDN 571
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1418308718 572 GSPVATGTGTLLLVLSDVNDN 592
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 267-372 1.65e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 1.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 267 VFQGSVTEGALPGTSVMQVTATDADDDVNtynAAIAYSILTQDPllpsSMMFTINKDTGVISVlTTGLDREGVPMYTLVV 346
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNE----DGLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1418308718 347 QAADLQGEGLTTTATAVITVTDINDN 372
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-483 3.17e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 3.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 380 TYQGRVPEN-KANVEIAVLKVTDADVPdtPAWRAVYTILNNNNDQ-FVVttDPVTndGILKTTKGLDFEDKQQYVLYVTV 457
Cdd:cd11304     1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGlFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*.
gi 1418308718 458 VNVTPFEVilsTSTATVTVDVEDVNE 483
Cdd:cd11304    75 TDGGGPPL---SSTATVTITVLDVND 97
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 607-687 1.08e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 607 NPQPHVINIIDPDLPPNTSPFTAELTHGASVNWTIEyndpaRESLILKPKKTL---ELGDYKINLKLTDN--QNKDQVTT 681
Cdd:pfam00028  12 GTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRID-----PDTGDISTTKPLdreSIGEYELTVEATDSggPPLSSTAT 86


                  ....*.
gi 1418308718 682 LDVFVC 687
Cdd:pfam00028  87 VTITVL 92
 
Name Accession Description Interval E-value
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 159-259 6.42e-41

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 145.18  E-value: 6.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 159 IPPISCPENEKGPfpKNLVQIKSNRDKEIKVFYSITGQGADAPPvGVFIIERETGWLKVTEPLDREQIAKYILYSHAVSS 238
Cdd:cd00031     1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                          90       100
                  ....*....|....*....|.
gi 1418308718 239 NGNAVEDPMEIVITVTDQNDN 259
Cdd:cd00031    78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-120 4.05e-39

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 139.77  E-value: 4.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718  31 PCRPGFGADSYTFTVPRRhLERGRVLGRVSFEGCTGLPRTAYVSDDTRFKVGTDGVITVKRPLQLHKPEISFLVHAWDSS 110
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRR-LEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 1418308718 111 -RRKLSTRVRL 120
Cdd:pfam08758  80 gEKMASVKVTV 90
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 32-118 6.07e-35

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 127.78  E-value: 6.07e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718   32 CRPGFGADSYTFTVPRrHLERGRVLGRVSFEGCTGLPRTAYVSDDTRFKVGTDGVITVKRPLQLHKPEISFLVHAWDSS- 110
Cdd:smart01055   1 CKPGFSEEKYTFHVPS-HLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQg 79


                   ....*...
gi 1418308718  111 RRKLSTRV 118
Cdd:smart01055  80 QEKKEIKV 87
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 820-879 8.14e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.69  E-value: 8.14e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 820 ADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 879
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 493-592 5.33e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 5.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 493 VVSIPEDFGVGQEITSYTAEDPDTYMEQRITYRIWR-DAAGWLEVNPESGAIFTRAELDREdfehvKNSTYEALIIAIDN 571
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1418308718 572 GSPVATGTGTLLLVLSDVNDN 592
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 267-372 1.65e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 1.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 267 VFQGSVTEGALPGTSVMQVTATDADDDVNtynAAIAYSILTQDPllpsSMMFTINKDTGVISVlTTGLDREGVPMYTLVV 346
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNE----DGLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1418308718 347 QAADLQGEGLTTTATAVITVTDINDN 372
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
160-254 9.04e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 9.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 160 PPISCPENEK-GPFPKNLVQIKSNRDKEIKVFYSITGQGADappvGVFIIERETGWLKVTEPLDREQIAKYILYSHAVSS 238
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1418308718 239 NGNAVEDPMEIVITVT 254
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
268-356 1.33e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 1.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 268 FQGSVTEGALPGTSVMQVTATDADDDVNTYnaaIAYSILTQDPLLpssmMFTINKDTGVISVlTTGLDREGVPMYTLVVQ 347
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGR---IFYSILGGGPGG----NFRIDPDTGDIST-TKPLDRESIGEYELTVE 72


                  ....*....
gi 1418308718 348 AADLQGEGL 356
Cdd:pfam00028  73 ATDSGGPPL 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 510-594 6.25e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 6.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718  510 TAEDPDTYMEQRITYRIWR-DAAGWLEVNPESGAIFTRAELDREdfehvKNSTYEALIIAIDNGSPVATGTGTLLLVLSD 588
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1418308718  589 VNDNGP 594
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-483 3.17e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 3.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 380 TYQGRVPEN-KANVEIAVLKVTDADVPdtPAWRAVYTILNNNNDQ-FVVttDPVTndGILKTTKGLDFEDKQQYVLYVTV 457
Cdd:cd11304     1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGlFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*.
gi 1418308718 458 VNVTPFEVilsTSTATVTVDVEDVNE 483
Cdd:cd11304    75 TDGGGPPL---SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
493-582 4.48e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 4.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 493 VVSIPEDFGVGQEITSYTAEDPDTYMEQRITYRIWRD-AAGWLEVNPESGAIFTRAELDREdfehvKNSTYEALIIAIDN 571
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDS 76

                          90
                  ....*....|.
gi 1418308718 572 GSPVATGTGTL 582
Cdd:pfam00028  77 GGPPLSSTATV 87
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 188-261 3.74e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 3.74e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1418308718  188 KVFYSITGQGADappvGVFIIERETGWLKVTEPLDREQIAKYILYSHAVSSNGNAVEDPMEIVITVTDQNDNKP 261
Cdd:smart00112  12 KVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
381-479 5.78e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 5.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 381 YQGRVPENKA-NVEIAVLKVTDADvpDTPAWRAVYTILNNN-NDQFVVTTDPvtndGILKTTKGLDFEDKQQYVLYVTVV 458
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPD--LGPNGRIFYSILGGGpGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|...
gi 1418308718 459 N--VTPfevilSTSTATVTVDVE 479
Cdd:pfam00028  75 DsgGPP-----LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 286-374 1.07e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 1.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718  286 TATDADDDVNtynAAIAYSILTQDPLLpssmMFTINKDTGVISVlTTGLDREGVPMYTLVVQAADLQGEGLTTTATAVIT 365
Cdd:smart00112   1 SATDADSGEN---GKVTYSILSGNDDG----LFSIDPETGEITT-TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 1418308718  366 VTDINDNPP 374
Cdd:smart00112  73 VLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 398-485 1.16e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 1.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718  398 KVTDADVPdtPAWRAVYTILNNNNDQ-FVVttDPVTndGILKTTKGLDFEDKQQYVLYVTVVNVTPFEvilSTSTATVTV 476
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGlFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVTI 71


                   ....*....
gi 1418308718  477 DVEDVNEAP 485
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
607-687 1.08e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 607 NPQPHVINIIDPDLPPNTSPFTAELTHGASVNWTIEyndpaRESLILKPKKTL---ELGDYKINLKLTDN--QNKDQVTT 681
Cdd:pfam00028  12 GTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRID-----PDTGDISTTKPLdreSIGEYELTVEATDSggPPLSSTAT 86


                  ....*.
gi 1418308718 682 LDVFVC 687
Cdd:pfam00028  87 VTITVL 92
 
Name Accession Description Interval E-value
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 159-259 6.42e-41

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 145.18  E-value: 6.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 159 IPPISCPENEKGPfpKNLVQIKSNRDKEIKVFYSITGQGADAPPvGVFIIERETGWLKVTEPLDREQIAKYILYSHAVSS 238
Cdd:cd00031     1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                          90       100
                  ....*....|....*....|.
gi 1418308718 239 NGNAVEDPMEIVITVTDQNDN 259
Cdd:cd00031    78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 31-120 4.05e-39

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 139.77  E-value: 4.05e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718  31 PCRPGFGADSYTFTVPRRhLERGRVLGRVSFEGCTGLPRTAYVSDDTRFKVGTDGVITVKRPLQLHKPEISFLVHAWDSS 110
Cdd:pfam08758   1 PCKPGFSEEVYTFSVPRR-LEEGQPLLNVKFNDCTGRKKTLYESSDPRFKVNTDGTVTAKRPVTLHGRQTSFLVHAWDSH 79

                          90
                  ....*....|.
gi 1418308718 111 -RRKLSTRVRL 120
Cdd:pfam08758  80 gEKMASVKVTV 90
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 32-118 6.07e-35

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 127.78  E-value: 6.07e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718   32 CRPGFGADSYTFTVPRrHLERGRVLGRVSFEGCTGLPRTAYVSDDTRFKVGTDGVITVKRPLQLHKPEISFLVHAWDSS- 110
Cdd:smart01055   1 CKPGFSEEKYTFHVPS-HLEAGQPLGRVNFEECLGSARLQFESSDPDFRVLEDGTVYATRPVSLSSEKKSFTVLAWDSQg 79


                   ....*...
gi 1418308718  111 RRKLSTRV 118
Cdd:smart01055  80 QEKKEIKV 87
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 820-879 8.14e-26

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 100.69  E-value: 8.14e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 820 ADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWGNRFKKLADMYG 879
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 493-592 5.33e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.22  E-value: 5.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 493 VVSIPEDFGVGQEITSYTAEDPDTYMEQRITYRIWR-DAAGWLEVNPESGAIFTRAELDREdfehvKNSTYEALIIAIDN 571
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1418308718 572 GSPVATGTGTLLLVLSDVNDN 592
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 267-372 1.65e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.29  E-value: 1.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 267 VFQGSVTEGALPGTSVMQVTATDADDDVNtynAAIAYSILTQDPllpsSMMFTINKDTGVISVlTTGLDREGVPMYTLVV 346
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNE----DGLFSIDPSTGEITT-AKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1418308718 347 QAADLQGEGLTTTATAVITVTDINDN 372
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
160-254 9.04e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.88  E-value: 9.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 160 PPISCPENEK-GPFPKNLVQIKSNRDKEIKVFYSITGQGADappvGVFIIERETGWLKVTEPLDREQIAKYILYSHAVSS 238
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 1418308718 239 NGNAVEDPMEIVITVT 254
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
268-356 1.33e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 1.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 268 FQGSVTEGALPGTSVMQVTATDADDDVNTYnaaIAYSILTQDPLLpssmMFTINKDTGVISVlTTGLDREGVPMYTLVVQ 347
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGR---IFYSILGGGPGG----NFRIDPDTGDIST-TKPLDRESIGEYELTVE 72


                  ....*....
gi 1418308718 348 AADLQGEGL 356
Cdd:pfam00028  73 ATDSGGPPL 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 510-594 6.25e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 6.25e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718  510 TAEDPDTYMEQRITYRIWR-DAAGWLEVNPESGAIFTRAELDREdfehvKNSTYEALIIAIDNGSPVATGTGTLLLVLSD 588
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 1418308718  589 VNDNGP 594
Cdd:smart00112  76 VNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-483 3.17e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 3.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 380 TYQGRVPEN-KANVEIAVLKVTDADVPdtPAWRAVYTILNNNNDQ-FVVttDPVTndGILKTTKGLDFEDKQQYVLYVTV 457
Cdd:cd11304     1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGlFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*.
gi 1418308718 458 VNVTPFEVilsTSTATVTVDVEDVNE 483
Cdd:cd11304    75 TDGGGPPL---SSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
493-582 4.48e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 4.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 493 VVSIPEDFGVGQEITSYTAEDPDTYMEQRITYRIWRD-AAGWLEVNPESGAIFTRAELDREdfehvKNSTYEALIIAIDN 571
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEATDS 76

                          90
                  ....*....|.
gi 1418308718 572 GSPVATGTGTL 582
Cdd:pfam00028  77 GGPPLSSTATV 87
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-259 2.29e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 69.65  E-value: 2.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 162 ISCPENEKGPFPknLVQIK-SNRDKEI--KVFYSITGQGADappvGVFIIERETGWLKVTEPLDREQIAKYILYSHAVSS 238
Cdd:cd11304     4 VSVPENAPPGTV--VLTVSaTDPDSGEngEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1418308718 239 NGNAVEDPMEIVITVTDQNDN 259
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 188-261 3.74e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.15  E-value: 3.74e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1418308718  188 KVFYSITGQGADappvGVFIIERETGWLKVTEPLDREQIAKYILYSHAVSSNGNAVEDPMEIVITVTDQNDNKP 261
Cdd:smart00112  12 KVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
381-479 5.78e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 5.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 381 YQGRVPENKA-NVEIAVLKVTDADvpDTPAWRAVYTILNNN-NDQFVVTTDPvtndGILKTTKGLDFEDKQQYVLYVTVV 458
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPD--LGPNGRIFYSILGGGpGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|...
gi 1418308718 459 N--VTPfevilSTSTATVTVDVE 479
Cdd:pfam00028  75 DsgGPP-----LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 286-374 1.07e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 1.07e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718  286 TATDADDDVNtynAAIAYSILTQDPLLpssmMFTINKDTGVISVlTTGLDREGVPMYTLVVQAADLQGEGLTTTATAVIT 365
Cdd:smart00112   1 SATDADSGEN---GKVTYSILSGNDDG----LFSIDPETGEITT-TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72


                   ....*....
gi 1418308718  366 VTDINDNPP 374
Cdd:smart00112  73 VLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 398-485 1.16e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 1.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718  398 KVTDADVPdtPAWRAVYTILNNNNDQ-FVVttDPVTndGILKTTKGLDFEDKQQYVLYVTVVNVTPFEvilSTSTATVTV 476
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGlFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVTI 71


                   ....*....
gi 1418308718  477 DVEDVNEAP 485
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
607-687 1.08e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1418308718 607 NPQPHVINIIDPDLPPNTSPFTAELTHGASVNWTIEyndpaRESLILKPKKTL---ELGDYKINLKLTDN--QNKDQVTT 681
Cdd:pfam00028  12 GTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRID-----PDTGDISTTKPLdreSIGEYELTVEATDSggPPLSSTAT 86


                  ....*.
gi 1418308718 682 LDVFVC 687
Cdd:pfam00028  87 VTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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