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Conserved domains on  [gi|1409114062|ref|WP_111765102|]
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polyphosphate--glucose phosphotransferase [Nakamurella deserti]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
Gene Ontology:  GO:0005524
PubMed:  20512568|17979299
SCOP:  3000092|4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 24-261 9.69e-127

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


:

Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 359.58  E-value: 9.69e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  24 FGIDIGGTGIKGGVVNLTDGTLIGERFRLDTPQPATPDAVSSTVHQIAEHFDYQGPYGCAFPGVVTHGVVHTAANMDESW 103
Cdd:cd24058     2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKSW 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 104 VGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLIIVVTFGTGIGTALINDGVLIPNAELGHIEIDGHDAET 183
Cdd:cd24058    82 IGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAEE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1409114062 184 KAAASARDRDGLNWEQWSKRANRYLTHLENLLWPELFIFGGGITKNPHKWVPHLKTRTPVKVAAMRNNAGIVGAALAA 261
Cdd:cd24058   162 RASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALLA 239
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 24-261 9.69e-127

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 359.58  E-value: 9.69e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  24 FGIDIGGTGIKGGVVNLTDGTLIGERFRLDTPQPATPDAVSSTVHQIAEHFDYQGPYGCAFPGVVTHGVVHTAANMDESW 103
Cdd:cd24058     2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKSW 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 104 VGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLIIVVTFGTGIGTALINDGVLIPNAELGHIEIDGHDAET 183
Cdd:cd24058    82 IGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAEE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1409114062 184 KAAASARDRDGLNWEQWSKRANRYLTHLENLLWPELFIFGGGITKNPHKWVPHLKTRTPVKVAAMRNNAGIVGAALAA 261
Cdd:cd24058   162 RASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALLA 239
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 23-263 2.86e-38

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 135.79  E-value: 2.86e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  23 AFGIDIGGTGIKGGVVNLtDGTLIgERFRLDTPQPATPDAVSSTVHQIAEHFDYQGPY--------GCAFPGVV--THGV 92
Cdd:COG1940     7 VIGIDIGGTKIKAALVDL-DGEVL-ARERIPTPAGAGPEAVLEAIAELIEELLAEAGIsrgrilgiGIGVPGPVdpETGV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  93 VHTAANMDeSWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLiIVVTFGTGIGTALINDGVLIP----N 168
Cdd:COG1940    85 VLNAPNLP-GWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNV-VYLTLGTGIGGGIVINGKLLRgangN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 169 A-ELGHIEIDGHDA----------ETKAAASA-----RDRDGLN---------------------WEQWSKRANRYLTHL 211
Cdd:COG1940   163 AgEIGHMPVDPDGPlcgcgnrgclETYASGPAllrraRELGGAEkltaeelfaaaragdplalevLDEAARYLGIGLANL 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1409114062 212 ENLLWPELFIFGGGITKNPHKWVPHLK------------TRTPVKVAAMRNNAGIVGAALAARE 263
Cdd:COG1940   243 INLLDPEVIVLGGGVSAAGDLLLEPIRealakyalpparEDPRIVPASLGDDAGLLGAAALALE 306
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 25-263 7.70e-24

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 97.41  E-value: 7.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKGGVVNLtDGTlIGERFRLDTPQPATPDAVSSTVHQI----AEHFDYQGPYGCAFPGVV--THGVVHTAAN 98
Cdd:pfam00480   2 GIDIGGTKIAAALFDE-EGE-ILARERVPTPTTTTEETLVDAIAFFvdsaQRKFGELIAVGIGSPGLIspKYGYITNTPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  99 MDesWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPgLIIVVTFGTGIGTALINDGVLI-----PNAELGH 173
Cdd:pfam00480  80 IG--WDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQ-NVIYVTVGTGVGGGVISNGKLFtgrngVAGEIGH 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 174 IEIDGHDA----------ETKAAASARDRDGLN------------------------WEQWSKRANRYLTHLENLLWPEL 219
Cdd:pfam00480 157 IQLDPNGPkcgcgnhgclETIASGRALEKRYQQkgedlegkdiivlaeqgdevaeeaVERLARYLAKAIANLINLFDPQA 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1409114062 220 FIFGGGITkNPHKWVPHLKTRTP-------------VKVAAMRNNAGIVGAALAARE 263
Cdd:pfam00480 237 IVLGGGVS-NADGLLEAIRSLVKkylngylpvppviIVAASLGDNAGALGAAALAKQ 292
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 26-179 2.01e-09

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 56.84  E-value: 2.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  26 IDIGGTGIKGGVVNlTDGTLIgERFRLDTPQPATPDAVSSTVHQI----AEHFDYqgpYGCAFPGVVTHGVVhTAANMDE 101
Cdd:PRK05082    6 IDIGGTKIAAALVG-EDGQIR-QRRQIPTPASQTPEALRQALSALvsplQAQADR---VAVASTGIINDGIL-TALNPHN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 102 --SWVGVSLVDAVSGHVPGPVTALNDADAAGLAEvrYGAGKGHPGLIIVVTFGTGIGTALINDGVLI--PNAELGHIeid 177
Cdd:PRK05082   80 lgGLLHFPLVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDDIRNMVFITVSTGVGGGIVLNGKLLtgPGGLAGHI--- 154


                  ..
gi 1409114062 178 GH 179
Cdd:PRK05082  155 GH 156
 
Name Accession Description Interval E-value
ASKHA_NBD_ROK_PPGK cd24058
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ...
 24-261 9.69e-127

nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466908 [Multi-domain]  Cd Length: 239  Bit Score: 359.58  E-value: 9.69e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  24 FGIDIGGTGIKGGVVNLTDGTLIGERFRLDTPQPATPDAVSSTVHQIAEHFDYQGPYGCAFPGVVTHGVVHTAANMDESW 103
Cdd:cd24058     2 LGIDIGGSGIKGAIVDTDTGELLSERIRIPTPQPATPEAVADVVAELVAHFPWFGPVGVGFPGVVRRGVVRTAANLDKSW 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 104 VGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLIIVVTFGTGIGTALINDGVLIPNAELGHIEIDGHDAET 183
Cdd:cd24058    82 IGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLTLGTGIGSALFVDGHLVPNTELGHLEIRGKDAEE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1409114062 184 KAAASARDRDGLNWEQWSKRANRYLTHLENLLWPELFIFGGGITKNPHKWVPHLKTRTPVKVAAMRNNAGIVGAALAA 261
Cdd:cd24058   162 RASLGVRAREDLGWKRWAKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLLDVKTPVVPAVLRNDAGIVGAALLA 239
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 23-263 2.86e-38

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 135.79  E-value: 2.86e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  23 AFGIDIGGTGIKGGVVNLtDGTLIgERFRLDTPQPATPDAVSSTVHQIAEHFDYQGPY--------GCAFPGVV--THGV 92
Cdd:COG1940     7 VIGIDIGGTKIKAALVDL-DGEVL-ARERIPTPAGAGPEAVLEAIAELIEELLAEAGIsrgrilgiGIGVPGPVdpETGV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  93 VHTAANMDeSWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLiIVVTFGTGIGTALINDGVLIP----N 168
Cdd:COG1940    85 VLNAPNLP-GWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNV-VYLTLGTGIGGGIVINGKLLRgangN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 169 A-ELGHIEIDGHDA----------ETKAAASA-----RDRDGLN---------------------WEQWSKRANRYLTHL 211
Cdd:COG1940   163 AgEIGHMPVDPDGPlcgcgnrgclETYASGPAllrraRELGGAEkltaeelfaaaragdplalevLDEAARYLGIGLANL 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1409114062 212 ENLLWPELFIFGGGITKNPHKWVPHLK------------TRTPVKVAAMRNNAGIVGAALAARE 263
Cdd:COG1940   243 INLLDPEVIVLGGGVSAAGDLLLEPIRealakyalpparEDPRIVPASLGDDAGLLGAAALALE 306
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 25-259 3.02e-36

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 128.74  E-value: 3.02e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKGGVVNLtDGTLIgERFRLDTPQPATPDAVSSTVHQIAEHFDYQGPY-------GCAFPGVV--THGVVHT 95
Cdd:cd23763     2 GIDIGGTKIRAALVDL-DGEIL-ARERVPTPAEEGPEAVLDRIAELIEELLAEAGVrerilgiGIGVPGPVdpETGIVLF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  96 AANMDEsWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLiIVVTFGTGIGTALINDGVLIPNA-----E 170
Cdd:cd23763    80 APNLPW-WKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNF-VYITLGTGIGGGIIIDGKLYRGAngaagE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 171 LGHIEIdghdaetkaaasardrdglnWEQWSKRANRYLTHLENLLWPELFIFGGGITKNPHKWV------------PHLK 238
Cdd:cd23763   158 IGHITV--------------------LEEAARYLGIGLANLINLLNPELIVLGGGVAEAGDLLLepireavrrralPPLR 217

                         250       260
                  ....*....|....*....|.
gi 1409114062 239 TRTPVKVAAMRNNAGIVGAAL 259
Cdd:cd23763   218 RRVRIVPSELGDDAGLLGAAA 238
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 25-259 3.77e-30

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 114.19  E-value: 3.77e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKGGVVNlTDGTLIgERFRLDTPQPATPDAVSSTVHQIAEhfDYQGPYGCAFPGVVTHGVV--HTAANMDES 102
Cdd:cd24068     4 GIDIGGTKIKYGLVD-ADGEIL-EKDSVPTPASKGGDAILERLLEIIA--ELKEKYDIEGIGISSAGQVdpKTGEVIYAT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 103 -----WVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGlIIVVTFGTGIGTALINDGVLIPNA-----ELG 172
Cdd:cd24068    80 dnlpgWTGTNLKEELEERFGLPVAVENDVNCAALAEKWLGAAKGLDD-FLCLTLGTGIGGAIILDGRLYRGAngsagELG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 173 HIEIDGHDA----------ETKAAASARDR-----------DGL----NWEQWSKRA----NRYLTHL----ENLLW--- 216
Cdd:cd24068   159 HMVVDPGGRpcccggkgclEQYASGTALVRrvaealgepgiDGReifdLADAGDPLAkevvEEFAEDLatglANLVHifd 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1409114062 217 PELFIFGGGITK-NPH-----------KWVPHLKTRTPVKVAAMRNNAGIVGAAL 259
Cdd:cd24068   239 PEVIVIGGGISAqGELfleelreelrkLLMPPLLDATKIEPAKLGNDAGLLGAAY 293
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 25-263 7.70e-24

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 97.41  E-value: 7.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKGGVVNLtDGTlIGERFRLDTPQPATPDAVSSTVHQI----AEHFDYQGPYGCAFPGVV--THGVVHTAAN 98
Cdd:pfam00480   2 GIDIGGTKIAAALFDE-EGE-ILARERVPTPTTTTEETLVDAIAFFvdsaQRKFGELIAVGIGSPGLIspKYGYITNTPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  99 MDesWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPgLIIVVTFGTGIGTALINDGVLI-----PNAELGH 173
Cdd:pfam00480  80 IG--WDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQ-NVIYVTVGTGVGGGVISNGKLFtgrngVAGEIGH 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 174 IEIDGHDA----------ETKAAASARDRDGLN------------------------WEQWSKRANRYLTHLENLLWPEL 219
Cdd:pfam00480 157 IQLDPNGPkcgcgnhgclETIASGRALEKRYQQkgedlegkdiivlaeqgdevaeeaVERLARYLAKAIANLINLFDPQA 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1409114062 220 FIFGGGITkNPHKWVPHLKTRTP-------------VKVAAMRNNAGIVGAALAARE 263
Cdd:pfam00480 237 IVLGGGVS-NADGLLEAIRSLVKkylngylpvppviIVAASLGDNAGALGAAALAKQ 292
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 24-257 7.34e-23

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 94.56  E-value: 7.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  24 FGIDIGGTGIKGGVVNlTDGTLIgERFRLDTPQpatpDAVSSTVHQIAEHFD-YQGPY-GCAF--PGVV--THGVVHTAA 97
Cdd:cd24152     3 LVFDIGGTFIKYALVD-ENGNII-KKGKIPTPK----DSLEEFLDYIKKIIKrYDEEIdGIAIsaPGVIdpETGIIYGGG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  98 ---NMDeswvGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGlIIVVTFGTGIGTALINDGVLI---PNA-- 169
Cdd:cd24152    77 alpYLK----GFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKN-GAVIVLGTGIGGAIIIDGKLYrgsHFFag 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 170 ELGHIEIDGHDAE-------------TKAAASARDRDGLNWEQWSKRA-----------NRYLTHLENLLW-------PE 218
Cdd:cd24152   152 EFSYLLTDDDDKDllffsglasmfglVKRYNKAKGLEPLDGEEIFEKYakgdeaakkilDEYIRNLAKLIYniqyildPE 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1409114062 219 LFIFGGGITKNP-------------HKWVPHLKTRTPVKVAAMRNNAGIVGA 257
Cdd:cd24152   232 VIVIGGGISEQPlfiedlkkevneiLANRPGSIPKPEIKACKFGNDANLLGA 283
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 23-262 5.09e-21

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 90.11  E-value: 5.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  23 AFGIDIGGTGIKGGVVNlTDGTLIGerfRLDTPQPATP----DAVSSTVHQIAEHFDYQGpYGCAFPGVVT--HGVVHTA 96
Cdd:cd24061     1 TIGVDIGGTKIAAGVVD-EEGEILA---TERVPTPPTAdgivDAIVEAVEELREGHDVSA-VGVAAAGFVDadRATVLFA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  97 ANMDesWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLIIvVTFGTGIGTALINDGVLIPNA-----EL 171
Cdd:cd24061    76 PNIA--WRNEPLKDLLEARIGLPVVIENDANAAAWAEYRFGAGRGTDDMVM-ITVGTGLGGGIVIGGKLLRGAfgiagEF 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 172 GHIEI--DGH----------------DAETKAAASARDRDGLN--------------------------------WEQWS 201
Cdd:cd24061   153 GHIRVvpDGLlcgcgsrgcweqyasgRALVRYAKEAANATPEGaavlladgsvdgitgkhiseaaragdpvaldaLRELA 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1409114062 202 KRANRYLTHLENLLWPELFIFGGGITKNPHKWVP--------HLKTRTP-----VKVAAMRNNAGIVGAALAAR 262
Cdd:cd24061   233 RWLGAGLASLAALLDPELFVIGGGVSDAGDLLLDpireaferWLPGRGWrpiprLRTAQLGNDAGLIGAADLAR 306
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 25-260 1.16e-17

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 80.45  E-value: 1.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKGGVVnlTDGTLIGerfRLDTPQPATP-----DAVSSTVHQIAEHFDYQGPYGCAFPGVVTH--GVVHTAA 97
Cdd:cd24065     4 GLDLGGTKIAAGVV--DGGRILS---RLVVPTPREGgeavlDALARAVEALQAEAPGVEAVGLGVPGPLDFrrGRVRFAP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  98 NMDEsWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLIIvVTFGTGIGTALINDGVLIPNA-----ELG 172
Cdd:cd24065    79 NIPG-LTDFPIRRGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVY-VTISTGIGGGLVLGGRVLRGRhgqagEIG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 173 HIEI--------DGHDA--ETKAAASARDRDGL--------------NWEQWSKRANR-----------YLTHLENLLWP 217
Cdd:cd24065   157 HTTVlpggpmcgCGLVGclEALASGRALARDASfaygrpmstaelfeLAQQGEPKALRiveqaaahlgiGLANLQKALDP 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1409114062 218 ELFIFGGGITKN-PHKWVPHLKT---------RTPVKVAAMRNNAGIVGAALA 260
Cdd:cd24065   237 EVFVLGGGVAQVgDYYLLPVQEAarrytegwhAPPLRLAHLGTDAGVIGAALA 289
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 24-179 5.05e-17

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 78.48  E-value: 5.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  24 FGIDIGGTGIKGGVVnlTDGTLIgERFRLDTPQPATP----DAVSSTVHQIAEHFDYqgpYGCAFPGVVTHGVV-HTAAN 98
Cdd:cd24069     1 LAIDIGGTKIAAALI--GNGQII-DRRQIPTPRSGTPealaDALASLLADYQGQFDR---VAVASTGIIRDGVLtALNPK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  99 MDESWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGhPGLIIVVTFGTGIGTALINDGVLI--PNAELGHIei 176
Cdd:cd24069    75 NLGGLSGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEG-VGNLVFITVSTGVGGGLVLNGQLLtgPNGLAGHI-- 151


                  ...
gi 1409114062 177 dGH 179
Cdd:cd24069   152 -GH 153
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 25-258 5.68e-17

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 78.87  E-value: 5.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKGGVVNlTDGTLIgERFRLDTPQ----PATPDAVSSTVHQIAEHFDYQGP----YGCAFPGVVT--HGVVH 94
Cdd:cd24062     4 GIDVGGTTIKMAFLT-QEGEIV-QKWEIPTNKleggENIITDIAESIQQLLEELGYSKEdligIGVGVPGPVDveTGTVE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  95 TAANMdeSWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLIIvVTFGTGIGTALINDGVLIPNA----- 169
Cdd:cd24062    82 VAVNL--GWKNFPLKDKLEALTGIPVVIDNDANAAALGEMWKGAGQGAKDLVF-ITLGTGVGGGVIANGKIVHGAngaag 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 170 ELGHIEIDGHDA-----------ETKAAASA---------RDRDGLNWEQWSK--------------------------R 203
Cdd:cd24062   159 EIGHITVNPEGGapcncgktgclETVASATGivriareelEEGKGSSALRILAlggeltakdvfeaakagdelalavvdT 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1409114062 204 ANRYL----THLENLLWPELFIFGGGITK------NPHKWV------PHLKTRTPVKVAAMRNNAGIVGAA 258
Cdd:cd24062   239 VARYLglalANLANTLNPEKIVIGGGVSAagefllSPVKEYfdrftfPRVRQDTEIVLATLGNDAGVIGAA 309
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 23-173 5.90e-16

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 75.73  E-value: 5.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  23 AFGIDIGGTGIKGGVVnltDGTL-IGERFRLDTPQ---PATPDAVSSTVHQIAEHFDYQGPYGCAFPGVV--THGVVhTA 96
Cdd:cd24057     2 YYGFDIGGTKIEFAVF---DEALqLVWTKRVPTPTddyAAFLAAIAELVAEADARFGVKGPVGIGIPGVIdpEDGTL-IT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  97 ANMDESwVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHP---GLIIvvtfGTGIGTALINDGVLIPNA---- 169
Cdd:cd24057    78 ANIPAA-KGRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPsvfGLIL----GTGVGGGLVVNGRLVGGRsgia 152


                  ....*
gi 1409114062 170 -ELGH 173
Cdd:cd24057   153 gEWGH 157
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 25-181 8.88e-14

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 69.52  E-value: 8.88e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKGGVVNLtDGTLIGERfRLDTPQPATPDAVSSTVHQIAEHF---DYQGPYGC-----AFPGVVTH--GVVH 94
Cdd:cd24076     5 GVELGVDYITVVVTDL-AGEVLWRR-EVPLPASDDPDEVLAQLAALIREAlaaAPDSPLGIlgigvGVPGLVDSedGVVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  95 TAANMDesWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHpGLIIVVTFGTGIGTALINDGVLIPNA----- 169
Cdd:cd24076    83 LAPNLG--WRDVPLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGV-SDLVYLSAGVGIGAGIILDGELYRGAsgfag 159

                         170
                  ....*....|..
gi 1409114062 170 ELGHIEIDGHDA 181
Cdd:cd24076   160 EIGHMTVDPDGP 171
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 22-259 1.02e-13

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 69.68  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  22 TAFGIDIGGTGIKGGVVNltDGTLIGERFRLDTPQPATPDAVSSTVHQIAE------HFDYQGPYGCAFPG--VVTHGVV 93
Cdd:cd24063     1 YYVAVDIGGTWIRAGLVD--EDGRILLKIRQPTPKTGDPGTVSEQVLGLIEtllskaGKDSIEGIGVSSAGplDLRKGTI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  94 HTAANMDESWVgvSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLiIVVTFGTGIGTALINDGVLIP----NA 169
Cdd:cd24063    79 VNSPNIKGKEI--PLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNL-VYITISTGIGGGVIVDGRLLLgkngNA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 170 -ELGHIEID---------GHDAETKAAASARD--RDGLNW-EQWSKRANRYLTHLE------------------------ 212
Cdd:cd24063   156 aEVGHLVVDtesglkcgcGGYGHWEAFASGRGipRFAREWaEGFSSRTSLKLRNPGgegitakevfsaarkgdplalkii 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1409114062 213 ---------------NLLWPELFIFGGGITKNPHKWVPHLKTRTP----------VKVAAMRNNAGIVGAAL 259
Cdd:cd24063   236 eklaryngrgianviNAYDPELIVIGGSVFNNNKDILDPLIEYLEknpaiskgpeIVLSELGDDVGLIGALA 307
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 23-177 3.29e-13

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 67.91  E-value: 3.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  23 AFGIDIGGTGIKGGVVNlTDGTLIGERFRLDTPQPATPDA---VSSTVHQIAEHFDYQGpYGCAFPGVVTH--GVVHTAA 97
Cdd:cd24064     1 VIGIDLGGTDTKIGIVD-ENGDILKKKTIDTKVENGKEDVinrIAETVNELIEEMELLG-IGIGSPGSIDRenGIVRFSP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  98 NMDEsWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGlIIVVTFGTGIGTALINDGVLIPN-----AELG 172
Cdd:cd24064    79 NFPD-WRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNH-IIGLTLGTGVGSGVICHGQLLTGydgiaAELG 156


                  ....*
gi 1409114062 173 HIEID 177
Cdd:cd24064   157 HVIVE 161
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 22-177 1.16e-10

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 60.51  E-value: 1.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  22 TAFGIDIGGTGIKGGVVNLTdgtliGERFRLDT-PQPATPDA---------VSSTvhQIAEHFdyqgpyGCAFPGV-VTH 90
Cdd:cd24060     1 SALAVDLGGTNLRVAIVSMK-----GEIVKKYTqPNPKTYEEridlilqmcVEAA--SEAVKL------NCRILGVgIST 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  91 G---------VVHTAANMDEsWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLIIVVTfGTGIGTALIN 161
Cdd:cd24060    68 GgrvnpregiVLHSTKLIQE-WSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVIT-GTGIGGGIIL 145

                         170       180
                  ....*....|....*....|.
gi 1409114062 162 DGVLIPN-----AELGHIEID 177
Cdd:cd24060   146 NHELIHGssfcaAELGHIVVS 166
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 25-259 1.50e-10

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 60.30  E-value: 1.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKGGVVNLTDGTLIgeRFRLDTPQP---ATPDAVSSTVHQIAEHFDYQGPYGCAFPGVVTH--GVVHtaaNM 99
Cdd:cd24066     3 GIDLGGTKIEGIALDRAGRELL--RRRVPTPRGdyeATLDAIADLVEEAEEELGAPATVGIGTPGSISPrtGLVK---NA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 100 DESWV-GVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHpGLIIVVTFGTGIGTALINDGVLIPNA-----ELGH 173
Cdd:cd24066    78 NSTWLnGKPLKADLEARLGRPVRIENDANCFALSEATDGAGAGA-GVVFGVILGTGVGGGIVVNGRVLTGAngiagEWGH 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 174 IEIDGHDA----------------ETK------------------------AAASARDRDGLNW-EQWSKRANRYLTHLE 212
Cdd:cd24066   157 NPLPWPDEdelpgppcycgkrgcvETFlsgpalerdyarltgktlsaeeivALARAGDAAAVATlDRFLDRLGRALANVI 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1409114062 213 NLLWPELFIFGGGITKNPH----------KWVPHLKTRTPVKVAAMRNNAGIVGAAL 259
Cdd:cd24066   237 NILDPDVIVLGGGLSNIDElytegpaalaRYVFSDEVETPIVKNKHGDSSGVRGAAW 293
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 25-263 1.75e-10

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 59.87  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKGGVVNlTDGTLIGERFRLDTPQPATPDAVSSTVHQIAEH-FDYQGPYGCA---FPGVVTHG--VVHTAAN 98
Cdd:cd24070     5 GIDIGGTNIRIGLVD-EDGKLLDFEKVPSKDLLRAGDPVEVLADLIREYiEEAGLKPAAIvigVPGTVDKDrrTVISTPN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  99 MDeSWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGhPGLIIVVTFGTGIGTA-LINDGVLIPN----AELGH 173
Cdd:cd24070    84 IP-GLDGVNLADILENKLGIPVILERDVNLLLLYDMRAGNLDD-EGVVLGFYIGTGIGNAiLINGKPLRGKngvaGELGH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 174 IEIDGHD----------AETKAAasardrdGLNWEQWSKRAN-------------------RYLTHLE-------NLLWP 217
Cdd:cd24070   162 IPVYGNGkpcgcgntgcLETYAS-------GRALEEIAEEHYpdtpildifvdhgdepeldEFVEDLAlaiateiNILDP 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1409114062 218 ELFIFGGGIT-----------KNPHKWVPHLKTRTPVKV--AAMRNNAGIVGAALAARE 263
Cdd:cd24070   235 DAVILGGGVIdmkgfpretleEYIRKHLRKPYPADNLKIiyAELGPEAGVIGAAIYAFD 293
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 26-179 2.01e-09

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 56.84  E-value: 2.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  26 IDIGGTGIKGGVVNlTDGTLIgERFRLDTPQPATPDAVSSTVHQI----AEHFDYqgpYGCAFPGVVTHGVVhTAANMDE 101
Cdd:PRK05082    6 IDIGGTKIAAALVG-EDGQIR-QRRQIPTPASQTPEALRQALSALvsplQAQADR---VAVASTGIINDGIL-TALNPHN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 102 --SWVGVSLVDAVSGHVPGPVTALNDADAAGLAEvrYGAGKGHPGLIIVVTFGTGIGTALINDGVLI--PNAELGHIeid 177
Cdd:PRK05082   80 lgGLLHFPLVQTLEQLTDLPTIALNDAQAAAWAE--YQALPDDIRNMVFITVSTGVGGGIVLNGKLLtgPGGLAGHI--- 154


                  ..
gi 1409114062 178 GH 179
Cdd:PRK05082  155 GH 156
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 23-177 2.36e-09

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 56.91  E-value: 2.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  23 AFGIDIGGTGIKGGVVNLTdGTLIGER---FRLDTPQPATPDAVSSTVHQIAEHFDYQGPY---GCAFPGVV--THGVVH 94
Cdd:cd24071     3 IIGVKIEEGYLVLALTDLK-GKILEKTripFDHETDPEKVIELIAENIKKLIKNKHVEKKLlgiGIAVSGLVdsKKGIVI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  95 TAANMdeSWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLiIVVTFGTGIGTALINDGVLIPNA----- 169
Cdd:cd24071    82 RSTIL--GWENVELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNF-ICVTVGAGIGSSLVIDGKLYTGNfggag 158


                  ....*...
gi 1409114062 170 ELGHIEID 177
Cdd:cd24071   159 EIGHMTIQ 166
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 23-258 3.83e-09

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 56.05  E-value: 3.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  23 AFGIDIGGTGIKGGVVNLTDGTLIGERFRLDTPQpaTPDAVSSTVHQIAEHFDYQGPY-------GCAFPG--VVTHGVV 93
Cdd:cd24059     3 VIGVEIGRDLLSAVLCDLSGNILAREKYPLDEKE--NPEEVLEKLYELIDRLLEKENIkskilgiGIGAPGplDVEKGII 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  94 HTAANMDEsWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLIIVVTfGTGIGTALINDGVLIPNA---- 169
Cdd:cd24059    81 LNPPNFPG-WENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILA-DEGIGAGIIINGKLYRGVdgya 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 170 -ELGHIEID------------------GHDAETKAAASARDRDGLNWEQWSKRAN--------------RYL----THLE 212
Cdd:cd24059   159 gEIGHTSIDingprcscgnrgclelyaSIPAIEKKARSALGSGRSFQLDIVEALQkgdpiadevieeaaKYLgiglVNLI 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1409114062 213 NLLWPELFIFGGGITKNPHKW------------VPHLKTRTPVKVAAMRNNAGIVGAA 258
Cdd:cd24059   239 NLLNPEAIIIGGELIYLGERYlepiekevnsrlFGRNAREVRILKSSLGEDAPLLGAA 296
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 23-177 6.45e-09

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 55.64  E-value: 6.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  23 AFGIDIGGTGIKGGVVNLTDGTLIGERFRLDTPqpaTPDAVSSTVHQIAEHFDYQGPY--------GCAFPGVVTH--GV 92
Cdd:cd24073     3 VVGVKLTEDRITAVLTDLRGNVLASHTLPLDSG---DPEAVAEAIAEAVAELLAQAGLspdrllgiGVGLPGLVDAetGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  93 VHTAANMDesWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLiIVVTFGTGIGTALINDGVLIPNA--- 169
Cdd:cd24073    80 CRWSPLLG--WRDVPLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNF-AVVTIGRGIGCGLVVDGRLYRGAhgg 156

                         170
                  ....*....|
gi 1409114062 170 --ELGHIEID 177
Cdd:cd24073   157 agEIGHTTVD 166
ASKHA_NBD_ROK_BsFRK-like cd24067
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ...
 25-259 4.07e-07

nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466917 [Multi-domain]  Cd Length: 285  Bit Score: 49.85  E-value: 4.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKGGVVnlTDGTLIGERFRLDTpqpATPDAvssTVHQIAEHFD-YQGPY---GCA-F------PGVVTHGVV 93
Cdd:cd24067     3 GIEAGGTKFVCAVG--TGDGNIIERTEFPT---TTPEE---TLQAVIDFFReQEEPIdaiGIAsFgpidlnPTSPTYGYI 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  94 HTAANmdESWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLiIVVTFGTGIGTALINDGVLIPNA---E 170
Cdd:cd24067    75 TTTPK--PGWRNFDILGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLDSL-AYITVGTGIGVGLVVNGKPVHGLlhpE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 171 LGHIEIDGHDAETK---------------AAASA-RDRDGLNWEQ-------WSKRAnRYLTHL-ENL---LWPELFIFG 223
Cdd:cd24067   152 MGHIRVPRHPDDDGfpgvcpfhgdcleglASGPAiAARWGIPAEElpddhpaWDLEA-YYLAQAcANLtltLSPERIVLG 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1409114062 224 GGITKNPH--------------KWVPHLKTRTPVK----VAAMRNNAGIVGAAL 259
Cdd:cd24067   231 GGVMQRPGlfprirekfrkllnGYLEVPRLLPDIDeyivPPALGNDAGILGALA 284
PRK09557 PRK09557
fructokinase; Reviewed
 25-258 3.42e-06

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 47.33  E-value: 3.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKggVVNLTDGTLIGERFRLDTPQ---PATPDAVSSTVHQIAEHFDYQGPYGCAFPGVVT--HGVVHtaaNM 99
Cdd:PRK09557    4 GIDLGGTKIE--VIALDDAGEELFRKRLPTPRddyQQTIEAIATLVDMAEQATGQRGTVGVGIPGSISpyTGLVK---NA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 100 DESWV-GVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHpGLIIVVTFGTGIGTAL-INDGVLIPN----AELGH 173
Cdd:PRK09557   79 NSTWLnGQPLDKDLSARLNREVRLANDANCLAVSEAVDGAAAGK-QTVFAVIIGTGCGAGVaINGRVHIGGngiaGEWGH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 174 IEIDGHDAETKA-----------------------------AASARDRDG---------------LNWEQWSKRANRYLT 209
Cdd:PRK09557  158 NPLPWMDEDELRyrnevpcycgkqgcietfisgtgfatdyrRLSGKALKGseiirlveegdpvaeLAFRRYEDRLAKSLA 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1409114062 210 HLENLLWPELFIFGGGI-------TKNPH---KWVPHLKTRTPVKVAAMRNNAGIVGAA 258
Cdd:PRK09557  238 HVINILDPDVIVLGGGMsnvdrlyPTLPAllkQYVFGGECETPVRKALHGDSSGVRGAA 296
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 81-267 7.86e-05

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 43.12  E-value: 7.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  81 GCAFPGVV---THGVVHTAANMDESWvgvSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGlIIVVTFGTGIGT 157
Cdd:cd24075    66 SITLPGLInpkTGVVHYMPHIQVKSW---PIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKD-SILVRIHHGIGA 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 158 ALINDGVLIP----NA-ELGHIEID--------GHDA--ETKAAASARDRD--------------------------GLN 196
Cdd:cd24075   142 GIIIDGKLFLgqngNAgEIGHIQIEplgerchcGNFGclETVASNAAIEQRvkkllkqgyasqltlqdctikdicqaALN 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 197 WEQWS----KRANRYL----THLENLLWPELFIFGGGITKNPHKWVPHLK------------TRTPVKVAAMRNNAGIVG 256
Cdd:cd24075   222 GDQLAqdviKRAGRYLgkviAILINLLNPQKIIIAGEITQADKVLLPVIKkciqsqalpdfrQELKIVASQLDHNSAIGA 301

                         250
                  ....*....|....
gi 1409114062 257 AALAAR---EQKLL 267
Cdd:cd24075   302 FALVKRallEGGLL 315
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 25-179 3.37e-04

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 41.25  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  25 GIDIGGTGIKGGVVNlTDGTLIGE-RFRLDTPqpATPDAVSStvhQIAEHFDYQGPYGC--------AFPGVVT--HGVV 93
Cdd:cd24072     5 GIVVSPNSLRAQVGN-ACGELLGEfEYRVITL--ETPEALID---EIIDCIDRLLKLWKdrvkgialAIQGLVDshKGVS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  94 HTAANMdeSWVGVSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLIiVVTFGTGIGTALINDGVLI-----PN 168
Cdd:cd24072    79 LWSPGA--PWRNIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFC-VINLDYGIGSAIVIDNKLYigassGS 155

                         170
                  ....*....|...
gi 1409114062 169 AELGH--IEIDGH 179
Cdd:cd24072   156 GEIGHtkVNPDGA 168
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 85-179 1.97e-03

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 38.83  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  85 PGVV--THGVVHTAANMD-ESWvgvSLVDAVSGHVPGPVTALNDADAAGLAEVRYGAGKGHPGLIIVVtFGTGIGTALIN 161
Cdd:cd24074    71 PGIIdpESGIVHRLPFYDiKNL---PLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIV-IDDDIGAGVIT 146

                          90       100
                  ....*....|....*....|...
gi 1409114062 162 DGVLIPN-----AELGHIEIDGH 179
Cdd:cd24074   147 DGQLLHAgssrlGELGHTQIDPY 169
ASKHA_NBD_GLK cd24008
nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7. ...
 23-182 4.38e-03

nucleotide-binding domain (NBD) of glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. Glucokinases are mainly found in invertebrates and microorganisms and highly specific for glucose. Glucokinases belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466858 [Multi-domain]  Cd Length: 313  Bit Score: 37.97  E-value: 4.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  23 AFGIDIGGTGIKGGVVNLTDGTL-IGERFRLDTPQPATPDAVsstVHQIAEHFDYQGPYGCAF--PGVVTHGVVHtAANM 99
Cdd:cd24008     1 ILVGDIGGTNARLALADAGDGSGdLLFVRKYPSADFASLEDA---LAAFLAELGAPRPKAACIavAGPVDGGRVR-LTNL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062 100 DesWV--GVSLVDAVSGhvpGPVTALNDADAAGLA----------EVRYGAGKGHPGLIIVVTFGTGIGTALI----NDG 163
Cdd:cd24008    77 D--WSidAAELRKALGI---GRVRLLNDFEAAAYGlpalgpedllVLYGGGGPLPGGPRAVLGPGTGLGVALLvpdgDGG 151

                         170
                  ....*....|....*....
gi 1409114062 164 VLIPNAELGHIEIDGHDAE 182
Cdd:cd24008   152 YVVLPSEGGHADFAPVTEE 170
Pan_kinase pfam03309
Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of ...
 26-153 7.07e-03

Type III pantothenate kinase; Type III pantothenate kinase catalyzes the phosphorylation of pantothenate (Pan), the first step in the universal pathway of CoA biosynthesis.


Pssm-ID: 460881 [Multi-domain]  Cd Length: 205  Bit Score: 36.77  E-value: 7.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1409114062  26 IDIGGTGIKGGVVnltDGTLIGERFRLDTPQPATPDAVSSTVHQIAEHFDYQGPYGCAFPGVVTHgVVHTAANMDESWVG 105
Cdd:pfam03309   4 IDIGNTNIKWGLF---DGDKLVAHWRISTDARRTADELGVLLRSLLRLAGIDPIDGVIISSVVPP-LNAALERACLKYFK 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1409114062 106 VSLVDAVSGHVPGPVTALND------AD--AAGLAEVRYGAGKGhpglIIVVTFGT 153
Cdd:pfam03309  80 IEPLVVGAPGIKTGLRNRYDnpkelgADrwVNAVAARELYPGKP----LIVVDFGT 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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