|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
17-388 |
3.03e-127 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 373.47 E-value: 3.03e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAG 96
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 97 MADSVYGVAFGRIIQGTGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAI 176
Cdd:cd17472 81 YATSIYGLILGRALQGSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 177 VGMLVVHYIVPNPTTKapAGDASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHHWWVYFPA 256
Cdd:cd17472 161 VSLLILLFFVPDPPKI--VQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 257 LLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAK 336
Cdd:cd17472 239 ILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYR 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1408604800 337 GSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGISLGL 388
Cdd:cd17472 319 GTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-380 |
5.09e-48 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 168.91 E-value: 5.09e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAG 96
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 97 MADSVYGVAFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAAL 174
Cdd:cd17325 80 FATSYWQLLLARFLQGlaSAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 175 AIVGMLVVHYIVPNPTTKAPAGDASTNSNK--LRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHHWWV 252
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRsgLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 253 YFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASgSVWLFALAIVLYFTAFNFLEASLPAMISMSAP 332
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1408604800 333 AGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
12-351 |
6.91e-42 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 151.67 E-value: 6.91e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 12 KAAVSLALVFGLRMLGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLG 91
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 92 SIVAGMADSVYGVAFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFF 169
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGlgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 170 VTAALAIVGMLVVHYIVPNPTTKAPAGDASTnsnkLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHH 249
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLRGS----LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 250 WWVYFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFAsGSVWLFALAIVLYFTAFNFLEASLPAMISM 329
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA-GSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
330 340
....*....|....*....|..
gi 1408604800 330 SAPAGAKGSAMGIYSTSQFAGA 351
Cdd:COG2814 324 LAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-380 |
3.64e-37 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 139.63 E-value: 3.64e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 12 KAAVSLALVFGlrMLGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLG 91
Cdd:cd17474 1 LYAVFFATLLA--VLGVSIVDPILPAIAEAL-GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 92 SIVAGMADSVYGVAFGRIIQGTGAVA--SAILALAADITREQQRPKVMAVIGMCIGLsfafALVAGPVLAQWIGLKG--- 166
Cdd:cd17474 78 GLLCGLSDSFALLLAGRALQGIGAAGlgPLALTLIGDLFEGGERAKAMGLYEAALGL----GIAVGPLLGGLLAAISwry 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 167 IFFVTAALAIVGMLVVHYIVPNPTTKAPAGDASTnSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVG 246
Cdd:cd17474 154 PFFLLAALIPVAFLAILFLLPEPKEKAKSSSATK-LRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 247 EHH-WWVYFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASgSVWLFALAIVLYFTAFNFLEASLPA 325
Cdd:cd17474 233 PIIiGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTT 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1408604800 326 MISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17474 312 LVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALA 366
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
25-377 |
4.70e-33 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 128.10 E-value: 4.70e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 25 MLGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGV 104
Cdd:cd17489 9 FLSFYLLLPVLPLYAHDL-GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 105 AFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVV 182
Cdd:cd17489 88 LVLRLIHGigWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 183 hYIVPNPTTKAPAGDASTNSNKLRsmLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVgehHWWVYFPALLLSFV 262
Cdd:cd17489 168 -FLVKDPPPVAAEEAEAGTRAFRR--LVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS---NAGLFFTVYAIALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 263 LMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFAsGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGI 342
Cdd:cd17489 242 LSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA-GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGT 320
|
330 340 350
....*....|....*....|....*....|....*
gi 1408604800 343 YSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAV 377
Cdd:cd17489 321 FFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVV 355
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
17-386 |
1.62e-29 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 118.06 E-value: 1.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLI--GYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIV 94
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 95 AGMADSVYGVAFGRIIQG-TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAA 173
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGlTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 174 LAIVGMLVVHYIVPNpttkapagdastnsnklrsmlrdpqLLRLDVGIFLLHLTLTAVFVSLPFELEAAGlvgehHWWVY 253
Cdd:cd17330 161 LALLNLVLVLFFLPP-------------------------LRRLLLVYFLIALAFAGLESVFSLFLKDRF-----GFSPS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 254 FPALLLSFVLMVPMLI------IAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYF-TAFNFleASLPAM 326
Cdd:cd17330 211 QIGLLLALVGIAGILAqlllipRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFgTGIVF--PALSAL 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 327 ISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGISL 386
Cdd:cd17330 289 LSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-380 |
3.93e-29 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 117.27 E-value: 3.93e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 28 LFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFG 107
Cdd:cd17324 15 EYVIQGLLPDIARDF-GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 108 RIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYI 185
Cdd:cd17324 94 RALAGlaHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 186 VPNPTTKAPAGDASTNSnkLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHHWWVyfpALLLSFVLMV 265
Cdd:cd17324 174 LPSLPPKKPGSLGLLSS--LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIG---LLLLFGVAGV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 266 PMLIIAAK--KKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAgAKGSAMGIY 343
Cdd:cd17324 249 VGSPLAGRlaDRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLASSLY 327
|
330 340 350
....*....|....*....|....*....|....*..
gi 1408604800 344 STSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17324 328 LAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLL 364
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-352 |
1.07e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 115.59 E-value: 1.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAG 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 97 MADSVYGVAFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAAL 174
Cdd:pfam07690 81 FASSLWLLLVLRVLQGlgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 175 AIVGMLVVHYIVPNPTTK--APAGDASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHHWWV 252
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKrpKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 253 YFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFA-SGSVWLFALAIVLYFTAFNFLEASLPAMISMSA 331
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSlTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|.
gi 1408604800 332 PAGAKGSAMGIYSTSQFAGAF 352
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGA 341
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-386 |
3.66e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 112.13 E-value: 3.66e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAG 96
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 97 MADSVYGVAFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWI--GLKGIFFVTA 172
Cdd:cd06174 80 FAPSFWLLLLGRFLLGlgSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 173 ALAIVGMLVVHYIVPNPTTKAPAGDAS----TNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFEL-EAAGLVGE 247
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEasskSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLlDLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 248 HHWWVYFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFLEASLpAMI 327
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF-ALI 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1408604800 328 SMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGISL 386
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
17-388 |
4.68e-27 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 111.55 E-value: 4.68e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAG 96
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 97 MADSVYGVAFGRIIQGTGA--VASAILALAADITREQQRPKVMAVIGMCIGLSFAFalvaGPVLAQWIGLKG---IFFVT 171
Cdd:cd17329 84 FAHSPWLFAIALVLTGFGGglFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAI----GPLLGGLLLLYSfrlLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 172 AALAIVGMLVVHYIVPNPTTKAPAGDASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEhhwW 251
Cdd:cd17329 160 AVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGE---S 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 252 VYFPALLLSFVLMVPMLIIAAK--KKMNKQFFL-FAIALMGLALCVMGFASGSVWLFALAIVLYFtAFNFLEASLPAMIS 328
Cdd:cd17329 237 LLGLLLALNALLIVLLQFPVARlvERFRLRKILmIGILLFAIGFAVLAFANTLAVLILAMIVLTL-GEMLVFPAVQTLVA 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 329 MSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGISLGL 388
Cdd:cd17329 316 ALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
25-380 |
1.27e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 110.74 E-value: 1.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 25 MLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGV 104
Cdd:COG2223 17 AFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 105 AFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVV 182
Cdd:COG2223 97 LLLGLLLGigGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 183 HYIVPNPTTKAPAgDASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHHWWVYFPALLLSFV 262
Cdd:COG2223 177 WLFLRDPPAGAAA-AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 263 LMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGI 342
Cdd:COG2223 256 LGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGL 335
|
330 340 350
....*....|....*....|....*....|....*...
gi 1408604800 343 YSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:COG2223 336 VGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLAL 373
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
32-380 |
6.75e-26 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 108.46 E-value: 6.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 32 MPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIG-RKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRII 110
Cdd:cd17490 16 VPFLSPYAESL-GASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 111 QG-TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPNP 189
Cdd:cd17490 95 SGiAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEER 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 190 TTKAPagdASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSlpFELEAAGLVGEHhwwvYFPALLLSFVLMVPMLI 269
Cdd:cd17490 175 REKKP---VLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFG--FTPLIAKQLGAS----SFQLGLLSIIYLLPNAL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 270 -------IAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFtAFNFLEASLPAMISMSAPAGAKGSAMGI 342
Cdd:cd17490 246 asllsgtLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGF-GTGILFPLLMSLSIEGVPAEQRSTAMGF 324
|
330 340 350
....*....|....*....|....*....|....*...
gi 1408604800 343 YSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17490 325 FQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALL 362
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
15-386 |
4.95e-25 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 105.73 E-value: 4.95e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 15 VSLALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIV 94
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 95 AGMADSVYGVAFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQwIGLKGIFFVTA 172
Cdd:cd17473 82 GLFLDSLYALLASRALLGigVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 173 ALAIVGMLVVHYIvpnPTTKAPAGDASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGehhwwv 252
Cdd:cd17473 161 LALPVLILVLLFL---PEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGS------ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 253 yfpALLLSFVLMVPMLIIAA--------KKKMNKQFFLF-AIALMGLALCVMGFASGsVWLFALAIVLYFTAFNFLEASL 323
Cdd:cd17473 232 ---AALIGLALAIASLAGAIgallfgrlKRRLGKRRLLAiGFALMALGFLLLALASG-LWVVLLGAILAGLGFGLLLPTL 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1408604800 324 PAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGS-QGLFFIIAAVMIVWFGISL 386
Cdd:cd17473 308 NSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGlSGAFLILGVLALVLAIVLL 371
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
17-380 |
3.69e-24 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 103.42 E-value: 3.69e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAG 96
Cdd:cd17320 4 LALLVALGPLAIDMYLPALPAIARDL-GASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 97 MADSVYGVAFGRIIQGTGAVASAILALAA--DITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAAL 174
Cdd:cd17320 83 LASSIEQLLIARFLQGLGAAAGSVVARAIvrDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 175 AIVGMLVVHYIVPnptTKAPAGDASTNSNKL----RSMLRDPQLLRldvGIFLLHLTLTAVFVslpFELEAAGLVGEHHw 250
Cdd:cd17320 163 GLLLLLLVLLFLP---ETLPEEKRKPLLSSLlrayKRVLKNRRFLG---YALALGLSFAGLFA---YLAAAPFIYIEQL- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 251 wvYFPALL--LSFVLMVPMLIIAA-------KKKMNKQFFLFAIALMGLALCVM----GFASGSVWLFALAIVLYFTAFN 317
Cdd:cd17320 233 --GLSPAQfgLLFALNAIALILGSllngrlvRRFGPRRLLRLGLLLLLAAALVLllaaLLGGLSLWPLVAPLFLIFFGFG 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1408604800 318 FLEASLPAMiSMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSqlGSQGLFFIIAAVMIV 380
Cdd:cd17320 311 LIFPNATSL-ALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN--GTALPMGLLILVLGL 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
29-388 |
1.41e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 101.49 E-value: 1.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 29 FMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGR 108
Cdd:COG2271 26 RSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLR 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 109 IIQGTG--AVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVvhyiv 186
Cdd:COG2271 106 FLLGLGeaGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 187 pnpttkapagdastnsnklrsmlrdpQLLRLDVGIFLLHLTLTAVFVSLPFEL-EAAGLVGEHHWWVYFPALLLSFVLMV 265
Cdd:COG2271 181 --------------------------RFWLLALAYFLVYFALYGFLTWLPTYLvEVRGLSLAQAGLLLSLPFLAGIVGSL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 266 PMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYST 345
Cdd:COG2271 235 LGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNT 314
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1408604800 346 SQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGISLGL 388
Cdd:COG2271 315 FGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
17-361 |
1.01e-21 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 96.11 E-value: 1.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAG 96
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREF-GTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 97 MADSVYGVAFGRIIQGTG-AVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALA 175
Cdd:cd17504 80 FAPNLPVLIAGRALQGIGgAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 176 IVGMLVVHYIVPnpttkapagdastnsnklrSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGehhwwvYFP 255
Cdd:cd17504 160 VLLAALVPLIDL-------------------RLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTG------FGL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 256 ALLLSFVLMVPMLIIA----------AKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFLEASLPA 325
Cdd:cd17504 215 GITEAGLLLLPGALVMliagplagrlIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPN 294
|
330 340 350
....*....|....*....|....*....|....*.
gi 1408604800 326 MISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSL 361
Cdd:cd17504 295 IVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
46-370 |
7.87e-21 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 93.78 E-value: 7.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 46 SPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGA--VASAILAL 123
Cdd:cd17321 29 SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAaaIMPASLAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 124 AADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVhyivpnpttkapagdastnsn 203
Cdd:cd17321 109 IAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA--------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 204 klrsmlrdPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHHWWVYFPALLLSFVLMVPMLIIAAKKKMNKQFFLF 283
Cdd:cd17321 168 --------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 284 AIALMGLALCVMGF--ASGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSL 361
Cdd:cd17321 240 GLLLTAVGLLLLALlgADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
....*....
gi 1408604800 362 YSQLGSQGL 370
Cdd:cd17321 320 LTAGLSANL 328
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-186 |
9.90e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 93.41 E-value: 9.90e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 9 LEQKAAVSLALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLF 88
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 89 CLGSIVAGMADSVYGVAFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKG 166
Cdd:cd17325 276 AVALLLLPLATSFWLLLLLLALLGlgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355
|
170 180
....*....|....*....|
gi 1408604800 167 IFFVTAALAIVGMLVVHYIV 186
Cdd:cd17325 356 PFLAAAALLLLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-409 |
5.88e-20 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 91.89 E-value: 5.88e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 8 KLEQKAAVSLALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIG-----RKPVII 82
Cdd:COG2211 6 KLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWIL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 83 AGLGLFCLGSIVAGMADSVYG------VAFGRIIQGTG--AVASAILALAADITRE-QQRPKVMAVIGMCIGLSFAFALV 153
Cdd:COG2211 86 IGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAytLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 154 AGPVLAQWI------GLKGIFFVTAALAIVGMLVVHYIVPNPttKAPAGDASTNSNKLRSMLRDPQLLRLDVGIFLLHLT 227
Cdd:COG2211 166 LPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKER--PVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 228 LTAVFVSLPFELEAAGLVGEHHWWVYFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFAS-GSVWLFA 306
Cdd:COG2211 244 LALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpGNLWLLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 307 LAIVLYFTAFNFLEASLPAMISMSAPAG-------AKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQG---------- 369
Cdd:COG2211 324 VLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsalt 403
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1408604800 370 ----LFFIIAAVMIVWFGISLGLENVGQVKAHTIAVTIANQREA 409
Cdd:COG2211 404 girlLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
30-380 |
2.06e-19 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 89.52 E-value: 2.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 30 MIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIG-RKPVIIAGLGLFCLGSIVAGMADSVYGVAFGR 108
Cdd:cd17370 17 MARSILPLFLVVL-GASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 109 IIQ--GTGAVASAILALAADITREQQRPKV------MAVIGMCIGLSFAFALVAgpvlAQWIGLKGIFFVTAALAIVGML 180
Cdd:cd17370 96 ILErlGKGIRTPPRDALLADATPPSGRGKAfglhraLDTLGAVLGPLLAALLLY----LLGGNYRTIFLLAAIPALLALL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 181 VVHYIVPNPTTKApagDASTNSNKLRSMLRDPQLLRLDVGIFLLhltlTAVFVSLPFELEAAGLVGEHHWW---VYFPAL 257
Cdd:cd17370 172 ILLFVVKEYPRPP---KLRKKSKKTSLKKLPKAFWLYLLAVALF----ALGNFSFAFLILRAQELGLSAALiplLYALFN 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 258 LLSFVLMVPMLIIAAKKKmnkQFFLFAIALMGLALCVMGFA-SGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAK 336
Cdd:cd17370 245 LVYALAAYPAGRLSDRIG---RKKLLILGYLSLALAYLGFAlGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELR 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1408604800 337 GSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17370 322 GTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-292 |
3.32e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 87.56 E-value: 3.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 12 KAAVSLALVFGLRMLGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLG 91
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADL-GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 92 SIVAGMADSVYGVAFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFF 169
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGigAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 170 VTAALAIVGMLVVHYIVPNPTTKAPAGDASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHH 249
Cdd:COG0477 173 INAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1408604800 250 WWVYFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLAL 292
Cdd:COG0477 253 LLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
23-380 |
4.90e-19 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 88.46 E-value: 4.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 23 LRMLGLFMIMPVFAIYGRDLIGYS---PLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMAD 99
Cdd:cd17388 10 LDAMGIGLIMPVLPTLLREFVGDSadaATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 100 SVYGVAFGRIIQG-TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFafalVAGPVLAQW---IGLKGIFFVTAALA 175
Cdd:cd17388 90 TLWWLYLGRIIAGiTGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGF----IAGPALGGLlgeISPRAPFLVAAGLN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 176 IVGMLVVHYIVPNPTTKAPAGDASTNSNK----LRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHHWW 251
Cdd:cd17388 166 GLNFLLGLFVLPESLPPERRRAFRWRRANpfgsLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 252 VYFPALLLSFVLMVPMLIIAAKKKM-NKQFFLFAIALMGLALCVMGFASGSVWLFalAIVLYFTAFNFLEASLPAMISMS 330
Cdd:cd17388 246 LSLAVFGLLHALFQAFVTGPIAKRLgEKRAILLGLAADALGFLLLAFATQGWMVF--PILILLALGGIAGPALQGLLSRQ 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1408604800 331 APAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQ--LGSQGLFFIIAAVMIV 380
Cdd:cd17388 324 VPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAAspATWPGLAWIIGAALYL 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-388 |
2.71e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 86.47 E-value: 2.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 1 MDNVALSKLEQKAAVSLALVFGLRMLGLFMIMPVFAI-----YGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRI 75
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVgpllpEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 76 GRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGaVASAILALAADITRE--QQRPKVMAVIGMCIGLSFAFALV 153
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG-IAVGNVLLPGLIKRWfpDRVGLMTGLYTAAMGLGAALAAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 154 AGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPNPTTKAPAGDASTnsnKLRSMLRDPQLLRLDVGIFLLHLTLTAVFV 233
Cdd:COG2807 160 LTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA---SLRSLWRSPLAWLLTLFFGLQSLLYYAVVA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 234 SLPFELEAAGLVGEHHWWVYFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYF 313
Cdd:COG2807 237 WLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLG 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1408604800 314 TAFNFleASLPAMISMSAPAGAK-GSAMGIYSTSQFAGAFCGGIIAGSLYSQLGS-QGLFFIIAAVMIVWFGISLGL 388
Cdd:COG2807 317 QGGLF--PLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGSwTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
15-386 |
1.60e-16 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 81.90 E-value: 1.60e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 15 VSLALVFGLRMLGLFMIMPVFAIYGRDlIGYSPLWVGIVIgAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIV 94
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVAD-LGPSSNSTWIST-AWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 95 AGMADSVYGVAFGRIIQGTGAVASAIL-ALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQ--WIGLKGIFFVT 171
Cdd:cd06179 79 AGTAKSVNMLIGGQALIGIGAGTQGLGaAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYIN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 172 AALAIVgMLVVHYIVPNPTTKAPAgdastNSNKLRSMLRdpqllRLD-VGIFLLHLTLTAVFVSLpfeleaaGLVGEHHW 250
Cdd:cd06179 159 AIFNAL-ALILLFFFYHPPPRPQL-----HGSSTRQKLK-----RLDwVGLFLLIAGLVLFLLGL-------SWGGNPYP 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 251 W----VYFPaLLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMG--LALCVMGFASGSVWLFALAIvlyftafnfleasLP 324
Cdd:cd06179 221 WssahVIAP-LVIGGVLLIAFGLYEWKGTKDGLLPPRLLFRGRnfALILIVAFVEGMIFYSLNIF-------------WP 286
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1408604800 325 AMISMSAPAGAkgSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGISL 386
Cdd:cd06179 287 QQISLLFTTDP--LKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLALL 346
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
51-187 |
3.82e-16 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 74.99 E-value: 3.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 51 GIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQG--TGAVASAILALAADIT 128
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGfgAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1408604800 129 REQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVP 187
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
22-380 |
4.13e-15 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 76.44 E-value: 4.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 22 GLRMLGLFMIMPVFAIYGrDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSV 101
Cdd:cd17477 6 ALLGLGSGLLLPLLSLRL-EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 102 YGVAFGRIIQGTG------AVASAILALAADitreQQRPKVMAVIGMCIGLSFAfalvAGPVLAQWIGLKG--IFFVTAA 173
Cdd:cd17477 85 WVWFLLRFVMGIGlaglfvVSESWLNALATN----ENRGRVLGLYSTVLGLGFA----LGPLLLALVGTAGalPFLIAAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 174 LAIVGMLVVhYIVPNPTTKAPAGDASTNSNKLRSMlrdPQLLrldVGIFLLHLTLTAVFVSLPFELEAAGLVGEHHWWVY 253
Cdd:cd17477 157 LLLLALVPL-LLTRRAAPEIEEAESISLRRLLRIA---PLAL---LGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 254 FPALLLSFVLMVPMLIIAakKKMNKQFFLFAIALMGLALCV--MGFASGSVWLFALAIVLYFTAFNFLEASLpAMISMSA 331
Cdd:cd17477 230 AAFVLGGLLLQWPLGWLA--DRFDRRRVLLGCALLGALAALllPLVPGLPLALLVLLFLWGGAAGPLYTLAL-ALAGDRL 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1408604800 332 PAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17477 307 PGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
22-207 |
3.07e-14 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 74.16 E-value: 3.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 22 GLRMLGLF---MIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMA 98
Cdd:PRK11043 13 GLSMLGFLatdMYLPAFKAIQADL-QTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 99 DSVYGVAFGRIIQGTGAVASAIL--ALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAI 176
Cdd:PRK11043 92 ESAAQLLVLRFVQAVGVCSAAVIwqALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAITL 171
|
170 180 190
....*....|....*....|....*....|.
gi 1408604800 177 VGMLVVHYIVPNPTTKAPAGDASTNSNKLRS 207
Cdd:PRK11043 172 LLILPTLRLKPSKKARKQSQDALTFKQLLKS 202
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
50-158 |
5.71e-14 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 72.60 E-value: 5.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 50 VGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGavASAILALA----A 125
Cdd:cd17502 32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIG--GGGLMSLAfiiiA 109
|
90 100 110
....*....|....*....|....*....|...
gi 1408604800 126 DITREQQRPKVMAvigmCIGLSFAFALVAGPVL 158
Cdd:cd17502 110 DLVPPRERGKYQG----YIGAVFGIASVAGPLI 138
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
23-382 |
1.83e-13 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 71.49 E-value: 1.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 23 LRMLGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVY 102
Cdd:cd17390 7 LDLFGVSMILPLLSTHIRSL-GASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 103 GVAFGRIIQG----TGAVASAILalaADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWI-GLKGIFFVTAALAIV 177
Cdd:cd17390 86 LLFLSRIPLGifkhTQSLCKAYL---SDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDgGFYYVALLCSAIFIL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 178 GMLVVHYIVPNpttkapagdastnsnklrsmLRDPQLLRLDVGI-FLLHLTLTAVFVSLPFELeAAGLVGehhwwvyfpa 256
Cdd:cd17390 163 NAGLVWFLLSK--------------------LWDLLLVRFLMGFsVLLFRSNFSLYLEERFDL-SPKTIG---------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 257 LLLSFVLMVPML-------IIAAKKKMNKQFFLFAIALMGLALCVMGFASgSVWLFALAIVLYFTAFNFLEASLPAMISM 329
Cdd:cd17390 212 YLISYSGVLGALsgflvgrILKLYKNNEYLLLLHSFILLALSLLGLALAP-SIWLLVLCLTPLSISSAVLRTCSTSLLLS 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1408604800 330 SAPAGAKGSAMG----IYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWF 382
Cdd:cd17390 291 RGKSKERGTLLGvgqsVTSLARILAPLLSGLLQEFSVSGPGLLGAVLALAAILLMLA 347
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
43-380 |
3.31e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 70.72 E-value: 3.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 43 IGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADS--------VYGVAFGRIIQGTg 114
Cdd:cd06173 29 LTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALlgslslwlLLVLAFLLGIASA- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 115 AVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPNPTTKAP 194
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 195 AGDASTNSNK---LRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHHWWVYFPALLLSFVLMvpMLIIA 271
Cdd:cd06173 188 ESSSLLLRDLregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG--ALLLG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 272 AKKKMNKQFFLFAIALMGLALCVMGFA-SGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAG 350
Cdd:cd06173 266 RLSKRRRRGRLLLIGALLLGLALLVLGlSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGA 345
|
330 340 350
....*....|....*....|....*....|
gi 1408604800 351 AFCGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd06173 346 MPLGALLAGLLADALGLSAVFLLAGALLLL 375
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
17-380 |
6.28e-13 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 69.88 E-value: 6.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIG-RKPVIIAGLGLFCLGSIVA 95
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 96 GMADSVYGV-AFGRIIQGTGAVASA-ILALA---ADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFV 170
Cdd:cd17471 81 AFLRNYWVLlLVGVVLLSLGAAAFPqLFALAreyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 171 TAALAIVGMLVVHYIVPNPTTKAPagdASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFEleaagLVGEHHW 250
Cdd:cd17471 161 AALLYLVVALLVLFLLPSVKPPAQ---KATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLY-----VTNELGG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 251 WVYFPALLLSF--VLMVPMLIIAAK--KKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFLeASLPAM 326
Cdd:cd17471 233 SESWVGLLFGLaaALEIPIMLLAGLlaKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGIT-AGLGIS 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1408604800 327 ISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLySQLGSQGLFFIIAAVMIV 380
Cdd:cd17471 312 YFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVI-AQYFGYRAVFLVCAVLAL 364
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
23-341 |
2.07e-12 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 68.55 E-value: 2.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 23 LRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVY 102
Cdd:PRK11646 21 LVVLGFFVVFPLISIRFVDQLGWAAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPW 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 103 GVAFGRIIQGTGAVA--SAILALAADITREQQRPKVM----------AVIGMCIG---LSFAFALVAgpvlaqWIGlkGI 167
Cdd:PRK11646 101 LLWLSCILSGLGGTLfdPPRTALVIKLIRPHQRGRFFsllmmqdsagAVIGALLGswlLQYDFRLVC------ATG--AV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 168 FFVTAALAIVGMLVVHYIvpnPTTKAPAGDAstnsnkLRSMLRDPQLLRLDvgifllhLTLT-----AVFVSLPFELEAA 242
Cdd:PRK11646 173 LFVLAAAFNAWLLPAYKL---STVRTPVREG------MTRVLRDKRFVTYV-------LTLTgyymlAVQVMLMLPIMVN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 243 GLVGEHHW--WVYFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALaIVLYFTAFNFLE 320
Cdd:PRK11646 237 DIAGSPSAvkWMYAIEACLSLTLLYPIARWSEKRFRLEHRLMAGLLIMSLSMFPIGMVSNLQQLFTL-ICLFYIGSIIAE 315
|
330 340
....*....|....*....|.
gi 1408604800 321 ASLPAMISMSAPAGAKGSAMG 341
Cdd:PRK11646 316 PARETLSASLADARARGSYMG 336
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
40-386 |
2.47e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 65.26 E-value: 2.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 40 RDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGAVA-- 117
Cdd:COG0738 35 KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLld 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 118 SAILALAADITREQQRPkVMAVIGMCIGL-SFAFALVAGPVLAQWIGL--KGIFFVTAALAIVGMLVVhYIVPNPTTKAP 194
Cdd:COG0738 115 VAANPYVAALGPETAAS-RLNLLHAFFSLgALLGPLLGGLLILLGLSLswHLPYLILAVLLLLLALLF-LRSKLPEIEEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 195 AGDASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHHWWVYFPALLLSFVLMVpMLIIAAKK 274
Cdd:COG0738 193 EEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR-FLGGFLLK 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 275 KMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLY--FTAFNFleaslPAMIS--MSAPAGAKGSAMGIYSTSQFAG 350
Cdd:COG0738 272 RFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVglGLSLMF-----PTIFSlaLDGLGKRTAAAVSAVLIMGIVG 346
|
330 340 350
....*....|....*....|....*....|....*.
gi 1408604800 351 AFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGISL 386
Cdd:COG0738 347 GAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLAL 382
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
43-386 |
2.84e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 64.51 E-value: 2.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 43 IGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGT--GAVASAI 120
Cdd:cd17319 33 LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVaeAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 121 LALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPnpttkapagdast 200
Cdd:cd17319 113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 201 nsnklrsmlrdpQLLRLDVGIFLLHLTLTAVFVSLPFEL-EAAGLVGEHHWWVYFPALLLSFVLMVpMLIIAAKKKMNKQ 279
Cdd:cd17319 180 ------------QVWGLALGYFGINYALYGLLTWLPTYLkQARGFSLKQVGLLAAIPFLAGAIGMI-LGGRLSDRLLRGA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 280 FFLFAIALMGLALCVMGFA--SGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGII 357
Cdd:cd17319 247 RRLVIIIGLLLAAVGLLLAylTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLL 326
|
330 340
....*....|....*....|....*....
gi 1408604800 358 AGSLYSQLGSQGLFFIIAAVMIVWFGISL 386
Cdd:cd17319 327 IGYLVDATGSYTAAFLFLAAVALLAALLV 355
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
14-215 |
4.04e-11 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 64.33 E-value: 4.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 14 AVSLALVFGLRMLGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSI 93
Cdd:TIGR00710 7 ALLLGCLSILGPLGIDMYLPAFPEIAADL-STPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 94 VAGMADSVYGVAFGRIIQGTGAVASAIL--ALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVT 171
Cdd:TIGR00710 86 GLALSNNIETLLVLRFVQAFGASAGSVIsqALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFL 165
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1408604800 172 AALAIVGMLVVHYIVPNPTTKAPAGDASTNSNKLRSMLRDPQLL 215
Cdd:TIGR00710 166 SLAGILLSALIFFILPETLPYEARIQISTYFETFLLLLKSKMFW 209
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
43-364 |
9.42e-11 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 63.36 E-value: 9.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 43 IGYSPLWVGIVIGAYGLTQAILqIPM-GQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQG--TGAVASA 119
Cdd:cd17503 26 LGASLDTVQWVITSYLLALAIM-IPLsGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGfgGGVLIPL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 120 ILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIvpnpttkapagdas 199
Cdd:cd17503 105 AQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL-------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 200 tnsnKLRsMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELE-AAGLVGEHHWWVYFPALLLSFVLMvPMLIIAAKKKMNK 278
Cdd:cd17503 171 ----DLR-LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQnVLGYSAFESGLVLAPGGLASAILS-PLVGRLLDKFGPR 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 279 QFFLFAIALMGLALCVMGFAS--GSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTS-QFAGAFCGG 355
Cdd:cd17503 245 LLLLAGLLLLALGTLLLAFLTpdTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIrQLGGSIGTA 324
|
....*....
gi 1408604800 356 IIAGSLYSQ 364
Cdd:cd17503 325 LLATLLTNR 333
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
46-380 |
9.72e-11 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 63.06 E-value: 9.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 46 SPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQG-TGAVASAILALA 124
Cdd:cd17389 62 SVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGiSKGNVSLSTAIV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 125 ADITREQQRPKVMAVigmcIGLSFAFALVAGPVLAQWIGL-----KGIFFVTAALAIVGMLVVHYIVPnpttkapagdas 199
Cdd:cd17389 142 ADVTSPKKRSKGMAL----IGVAFSLGFIIGPMIGAYFASftrslGEVFFSMPALFALVLALADLLFI------------ 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 200 tnSNKLRSMLrdPQLLRLDVGIFLLHLTLtavFVSLPFELeaaglvgehhwwVYFPALLLSFVLM----------VPMLI 269
Cdd:cd17389 206 --FFFLPETL--PSNLRRLGLVYFLYLFL---FSGLEFTL------------TFLTHQRFQYTSMqqgkmfffigIIMAL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 270 I----AAKKKMNKQ--FFLFAIALMGLALCVMGFASgSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIY 343
Cdd:cd17389 267 VqggyVRRIKPGKEkkAVLQGLILLIPAFLLIGWAS-SVTVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIF 345
|
330 340 350
....*....|....*....|....*....|....*...
gi 1408604800 344 -STSQFAGAFcGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17389 346 rSLGALARAL-GPIVACTVYWLAGSEACYTIGALLFLL 382
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
46-380 |
1.28e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 62.62 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 46 SPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQG--TGAVASAILAL 123
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGigIGGEYPGASTY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 124 AADITREQQRPKVMAVIGMCIGLSFAFALVAG----PVLAQWIGLKGIFFVTAALAIVGMLVVhyivpnpttkapagdas 199
Cdd:cd17316 114 VAEFAPSKRRGFALGLLQSGWALGALLAALVAslliPLLSGDWGWRILFLIGALPALLALLLR----------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 200 tnsnklrsmlrdPQLLRLDVGIFLLHLTLTAVFVSLPFELEAA-GLVGEHHWWVYFPALLLSFVLMVPMLIIAAKKKMNK 278
Cdd:cd17316 177 ------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 279 QFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIA 358
Cdd:cd17316 245 TLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLI 324
|
330 340
....*....|....*....|..
gi 1408604800 359 GSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17316 325 ALLLASTGGTGVPALILALLAI 346
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-146 |
1.36e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 62.68 E-value: 1.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 9 LEQKAAVSLALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLF 88
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 89 CLGSIVAGMADSVYGVAFGRIIQGTG--AVASAILALAADITREQQRPKVMAVIGMCIGL 146
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGfgLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
50-368 |
1.60e-10 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 62.60 E-value: 1.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 50 VGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRI-IQGTGAVASAILA-LAADI 127
Cdd:PRK03545 46 VGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIgIAFAHAIFWSITAsLAIRV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 128 TREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPNPttkapagdASTNSNKLRS 207
Cdd:PRK03545 126 APAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGALITLLLLIKLLPLL--------PSEHSGSLKS 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 208 MlrdPQLLR--LDVGIFLLH-LTLTAVFVSL----PFELEAAGLVGEhhwwvYFPALLLSFVLM-VPMLIIAAK--KKMN 277
Cdd:PRK03545 198 L---PLLFRrpALVSLYLLTvVVVTAHFTAYsyiePFVQQVAGLSEN-----FATLLLLLFGGAgIIGSVLFSRlgNRHP 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 278 KQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPaGAKGSAMGIYStsqfaGAFCGGII 357
Cdd:PRK03545 270 SGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVLKLAP-DATDVAMALFS-----GIFNIGIG 343
|
330
....*....|.
gi 1408604800 358 AGSLysqLGSQ 368
Cdd:PRK03545 344 AGAL---LGNQ 351
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
26-187 |
1.95e-10 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 62.24 E-value: 1.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 26 LGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVA 105
Cdd:PRK11102 5 LAIDMYLPALPVIAADF-GVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 106 FGRIIQGTGAVASAIL--ALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVH 183
Cdd:PRK11102 84 YMRFLHGLAAAAASVVinALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVF 163
|
....
gi 1408604800 184 YIVP 187
Cdd:PRK11102 164 FFIP 167
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
53-177 |
2.11e-10 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 62.23 E-value: 2.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 53 VIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGAVASAILA--LAADITRE 130
Cdd:PRK11652 48 VMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMArtLPRDLYEG 127
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1408604800 131 QQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIV 177
Cdd:PRK11652 128 TQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAG 174
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
19-182 |
2.42e-10 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 61.79 E-value: 2.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 19 LVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMA 98
Cdd:cd17370 205 YLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALG 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 99 DSVYGVAFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFA-LVAGpVLAQWIGLKGIFFVTAALA 175
Cdd:cd17370 285 SSLWLLLLGFILWGlyMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLAsLIAG-YLWDLISPSAAFLFSAVLA 363
|
....*..
gi 1408604800 176 IVGMLVV 182
Cdd:cd17370 364 LIALLLL 370
|
|
| MFS_BCD_PucC-like |
cd06176 |
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ... |
50-381 |
5.64e-10 |
|
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 349950 [Multi-domain] Cd Length: 409 Bit Score: 60.98 E-value: 5.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 50 VGIVIGAYGLTQaILQIPMGQLSDRIG-----RKPVIIAGLGLFCLGSIVAG-----MADS-------VYGVAFGRIIQG 112
Cdd:cd06176 38 VGLLIALHYLVA-PLRVWIGHRSDTHPlrgyrRTPYIWLGMLLLALGLALAPfaallLAGAafwlglaLAVLAFLLYGIG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 113 TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAF-ALVAGPVLAQWI--GLKGIF----FVTAALAIVGMLVVHYI 185
Cdd:cd06176 117 VGAAGTAFLALLADLTPEERRPRAVTVVWTMLILGIIVtAIVFGRLLDPYSpeRLIQVFqivaLVALLLALLALWGVERR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 186 VPNPTTKAPAGDASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSL-PFELEAAGL-VGE----HHWWVYfpALLL 259
Cdd:cd06176 197 RSRAALAAEEAPPETFREALRLLWASPQARRFFIFLFLSTLALFMQDVILePFGGEVFGMsVGEttrlTAIWGG--GTLL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 260 SFVLMVPMLIIAAKKKMNKQFFLFAIALmGLALCVMGFASGSVWLFALAIVLYFTAFN-FLEASLPAMISMsAPAGAKGS 338
Cdd:cd06176 275 GMLLAGFLLSRRLGKKRTAALGCLLSAL-GFLLLALAGLLGNPWLFRPGVFLLGLGNGlFTVGALTLMMDL-TGEGTAGL 352
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1408604800 339 AMGIYSTSQFAGAFCGGIIAGSLYSQLGSQ--------GLFFIIAAVMIVW 381
Cdd:cd06176 353 FMGLWGAAQALARGLGTLLGGALRDLLRALfgspalayGLVFLLEAVLLLV 403
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
12-182 |
1.21e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 59.49 E-value: 1.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 12 KAAVSLALVFGLRMLGLFMIMPVFAIygrdLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLG 91
Cdd:cd17477 191 PLALLGAFVAGFLEGAFYSLLPLYGL----RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALA 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 92 SIVAGMADSVYGVAFGrIIQGTGAVASAI----LALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGI 167
Cdd:cd17477 267 ALLLPLVPGLPLALLV-LLFLWGGAAGPLytlaLALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGL 345
|
170
....*....|....*
gi 1408604800 168 FFVTAALAIVGMLVV 182
Cdd:cd17477 346 FLFLAAVALLFLLFL 360
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
68-382 |
2.26e-09 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 58.77 E-value: 2.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 68 MGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIiqgtGAVASAIL----ALAADITREQQRPKVMAVIGMC 143
Cdd:cd17331 55 FGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRL----PSVFMHAMqaaqMVVTDLTDPGERAAALGRLGLS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 144 IGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPNPT----TKAPAGDAST----NSNKLRSMLRDPQLL 215
Cdd:cd17331 131 YGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTkskrEKEAKESASPpsvfNLKEILRLLRLPGVA 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 216 RLDVGIFLLhLTLTAVFVSL--PFELEAAGLVGEHHWWVYFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALC 293
Cdd:cd17331 211 FLLLVKLLS-GLPIGMFQSMfsLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 294 VMGFASGSVWLFALAIVLYFtAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGL--- 370
Cdd:cd17331 290 LLAFVTTVWQLLVLLLPLVI-GGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFgll 368
|
330
....*....|...
gi 1408604800 371 -FFIIAAVMIVWF 382
Cdd:cd17331 369 gAAINGLLTVYLL 381
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
51-186 |
2.52e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 58.76 E-value: 2.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 51 GIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTG--AVASAILALAADIT 128
Cdd:cd17489 230 GLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfgLLFPALQALAVDLV 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1408604800 129 REQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIV 186
Cdd:cd17489 310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
25-380 |
2.62e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 58.82 E-value: 2.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 25 MLGLFMIMPVFAIYGRDLIGYSP----LWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVII-AGLGL-FCLGSIvaGMA 98
Cdd:cd17391 9 GIGFSLIAPFLPLYIEQLGVTSGglveLWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLrASLGMaIVIGLM--AFV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 99 DSVYGVAFGRIIQGT-GAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAA-LAI 176
Cdd:cd17391 87 TNVWQLLILRLLQGVfSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGlLFL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 177 VGMLVVHYIVPNPTTKAPAGDASTNSnKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPF---ELEA--------AGLV 245
Cdd:cd17391 167 AFLLTLFFVKEDFKPVEKKKMVSTKE-VWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLyirQLMGdasnlafiSGLV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 246 gehhwwvyFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFtAFNFLEASLPA 325
Cdd:cd17391 246 --------FSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGL-ATGGLLPAINS 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1408604800 326 MISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17391 317 LLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLL 371
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
50-380 |
2.95e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 58.40 E-value: 2.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 50 VGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIiaGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGAVASAILALAADIT- 128
Cdd:cd17475 33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVL--AVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIm 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 129 ---REQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIV-GMLVVHYIVPNPTTKAPAGDASTNSNK 204
Cdd:cd17475 111 rwfPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILaAVLFWLFYREPPAASAATESASTLLRS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 205 LRSMLRDPQLLRLDVGIFLLHLTLTAVFV-SLPFELEAAGLVGEHHWWVYFPALLLSFVLMVPMLIIAAK--KKMNKQFF 281
Cdd:cd17475 191 LKEVLRNRDVWLIAIAGALLVAPQFALLTfLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRvfGGRRRPVL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 282 LFAIALMGLALCVMGFASGSVW---LFALAIVLYFTAFNFLEASLpAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIA 358
Cdd:cd17475 271 VITAAIAAAALLVLSLLSPGTPlwlLVLLLILLGLFAIGWNGLYL-TLVAESAGPEQAGTALGLANTINFIGIAIGPPLF 349
|
330 340
....*....|....*....|..
gi 1408604800 359 GSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17475 350 GLLVDATHSYAPAWLALALLLV 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-187 |
3.93e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 57.96 E-value: 3.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGR--KPVIIAGLGLFCLGSIV 94
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 95 AGMADSVYGVAFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTA 172
Cdd:COG2271 265 LALLPSPALAIALLFLAGfgLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLA 344
|
170
....*....|....*
gi 1408604800 173 ALAIVGMLVVHYIVP 187
Cdd:COG2271 345 ALALLAALLALLLLR 359
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
69-180 |
5.85e-09 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 57.72 E-value: 5.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 69 GQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGAVASAILALAA--DITREQQRPKVMAVIG--MCI 144
Cdd:PRK10473 59 GKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAIlrDTLDDRRRAKVLSLLNgiTCI 138
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1408604800 145 glsfafALVAGPVLAQWIGLK----GIFFVTAALA-IVGML 180
Cdd:PRK10473 139 ------IPVLAPVLGHLIMLKfpwqSLFYTMAAMGiLVLLL 173
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
19-193 |
1.37e-08 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 57.00 E-value: 1.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 19 LVFGLRMLGLFM----------IMPVFAIYgrdlIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLF 88
Cdd:TIGR00711 2 LLTIVLMLGTFMavldstivnvAIPTIAGD----LGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 89 CLGSIVAGMADSVYGVAFGRIIQGTGAVASAILALA--ADITREQQRPKVMAVIGMCIglsfAFALVAGPVLAQWI---- 162
Cdd:TIGR00711 78 TLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFStlLNIYPPEKRGRAMAIWGLTV----LVAPALGPTLGGWIieny 153
|
170 180 190
....*....|....*....|....*....|.
gi 1408604800 163 GLKGIFFVTAALAIVGMLVVHYIVPNPTTKA 193
Cdd:TIGR00711 154 HWRWIFLINVPIGIIVVVVAFFILPRDKPAA 184
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-378 |
2.61e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 55.74 E-value: 2.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 13 AAVSLALVFGLRMLGLFMIMPVFAIYGrdligYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGS 92
Cdd:cd17355 8 TFLILILSWGIRYYFGVFIIPIIAEFG-----WSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 93 IVAGMADSV---YGVAFGRIIQGTGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFF 169
Cdd:cd17355 83 VLLALATSLwqlYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 170 VTAALAIVGMLVVHYIVPNPTTKAPAGDASTNSNK-----LRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGL 244
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALRAYDDASPAspgstLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 245 VGEHHWWVYfpALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFLEASLP 324
Cdd:cd17355 243 SPAAAAVAL--ALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLT 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1408604800 325 AMISMSA-PAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVM 378
Cdd:cd17355 321 AALAARYfGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVAL 375
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
52-188 |
3.20e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 55.27 E-value: 3.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 52 IVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQgtGAVASAILALA----ADI 127
Cdd:cd17323 38 LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQ--GFFGSSPLAIGagtiADL 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1408604800 128 TREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPN 188
Cdd:cd17323 116 FTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLPI 176
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
43-193 |
3.89e-08 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 54.96 E-value: 3.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 43 IGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGA---VASA 119
Cdd:cd17476 28 FGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPaflLPNA 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1408604800 120 ILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVgMLVVHYIVPNPTTKA 193
Cdd:cd17476 108 MALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAI-VAVAAIFWTSPSFIA 180
|
|
| MFS_MFSD8 |
cd17326 |
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ... |
51-158 |
1.16e-07 |
|
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340884 [Multi-domain] Cd Length: 374 Bit Score: 53.75 E-value: 1.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 51 GIVIGAYGLTQAILQIPMGQLSDRIG-RKPVIIAGLGLFCLGSIVAGMADSV-----YGVAFGRIIQGTGAVASAIL-AL 123
Cdd:cd17326 39 GWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALAEYFpsnrkYVMLVARFLIGVGAGNVAVLrAY 118
|
90 100 110
....*....|....*....|....*....|....*
gi 1408604800 124 AADITREQQRPKVMAVIGMCIGLSFafalVAGPVL 158
Cdd:cd17326 119 VAAASTLKDRTRAMAVISAAQALGF----IVGPAL 149
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
59-196 |
1.17e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 53.78 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 59 LTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGAVASAILA--LAADITREQQRPKV 136
Cdd:cd17328 45 ISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAptIIADLFPKEKRTRA 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1408604800 137 MAVIGMCIGLSFAFALVAGPVLAQWI-GLKGIFFVTAALAIVGMLVVHYIVPNPTTKAPAG 196
Cdd:cd17328 125 LGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEG 185
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
11-185 |
1.24e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.39 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 11 QKAAVSLALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCL 90
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 91 GSIVAGMADSVYGVAFGRIIQGTGAVASAILALAA--DITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIF 168
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLlqLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*..
gi 1408604800 169 FVTAALAIVGMLVVHYI 185
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
34-381 |
7.02e-07 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 51.31 E-value: 7.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 34 VFAIYGRDLIGY-----SPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIiagLGLFCLGSIVAGMA------DSVY 102
Cdd:COG2270 33 VFPPYFTSVAALgdpaaATALWGYALAIAGLLVALLAPVLGAIADRSGRKKPF---LAFFTLLGVLATAAlffvapGGLW 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 103 GVAFGRIIQGTGAVASAIL--ALAADITREQQRPKV------MAVIGMCIGLSFAFALVAGPvlaQWIGLKG-------I 167
Cdd:COG2270 110 LGLLLFVLANIGFEGSLVFynAFLPDIATPEEIGRVsglgwaLGYLGGVLLLLINLALFLKP---EAFGLPDageavriS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 168 FFVTAALAIVGMLVVHYIVPNPTTKAPAGDAS--TNSNK-----LRSMLRDPQLLRLDVGIFLLH------LTLTAVFVS 234
Cdd:COG2270 187 FLLTALWWLLFALPLFLFLPERPRPGPAPPRGavRAGFRelrrtLRELRRYRDLLRFLLAYFFYRdgvqtvIAFAGIYAA 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 235 LPFELEAAGLVgehhwwVYFpaLLLSFVLMVPMLIIA--AKKKMNKQFFLFAIALMGLAlCVMGFASGSVWLFALAIVLY 312
Cdd:COG2270 267 GVLGFSTTELI------VFG--LLVQIVAALGALLFGrlDDRIGPKRVILVSLVIWIVV-CLAAYFLTTALAFWILGLLI 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1408604800 313 FTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQ-------GLFFIIAAVMIVW 381
Cdd:COG2270 338 GLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQLTGSQrlgilslIVFFVIGLVLLLR 413
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
44-388 |
7.43e-07 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 51.06 E-value: 7.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 44 GYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYG----VAFG---RIIQGTGAV 116
Cdd:cd17385 30 GVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFLDRVPDgtvfIALCflvRIVEAVGFA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 117 AS--AILALAADITreqqrPK----VMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPNPT 190
Cdd:cd17385 110 AFitASFAIIAKEF-----PNniatVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFILPRYD 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 191 tkapagdaSTNSNKLRSMLRdpqLLRLdVGIFLLHLTLTAVFVSLPFeLEA------------AGLVGehhwwVYFPALL 258
Cdd:cd17385 185 --------DDPSPKSGSMLK---LLKI-PSVLLLCLSIVSGSVSLGF-LDPtlsphlrqfklsPGQVG-----LMFLILA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 259 LSFVLMVPML-IIAAKKKMNKQFFLFAIALMGLALCVMGFA-----SGSVWLFALAIVLyfTAFNFLEASLPAMISMSAP 332
Cdd:cd17385 247 GSYAISAPLWgWLSDKKKIPKWLMVIGSIITGVGFLLLGPApllpiKSELWMVIIGLVL--LGLSLGAALVPTFPELLNC 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1408604800 333 AGAKG-----SAMGIYS---TSQFA-GAFCGGIIAGSLYSQLGsqglfFIIAAVMIVWFGISLGL 388
Cdd:cd17385 325 AREYGfpdnlSTYGLVSglfNAAFSlGAFIGPTLGGFLLERLG-----FEWAATIQAGLAFVVGI 384
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
43-386 |
8.69e-07 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 51.09 E-value: 8.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 43 IGYSPLWVGIVIGAYGLTQAILQIPMGQLSDR----IG-RKPVIIAGLGLFCLGSIVAGMADSvYGVAFGRIIQGTGAVA 117
Cdd:cd17313 29 LGLSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAAD-IGLALGDGPRTWALVL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 118 SAIL----------------ALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVL--------AQWIGLKGIFFVTAA 173
Cdd:cd17313 108 FVLGivlldfamnvcqgpvrALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILwdhnwfgfALGGNLKVPFYIGAI 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 174 LAIVGMLVVHYIVPNPT-------TKAPAGDASTNSNKLRSMLR-DPQLLRLDVGIFllhLTLTAVFvslPFELEAAGLV 245
Cdd:cd17313 188 ILLVCVLVTLFFVKEPPlspeageHSENPSLGEVLKSLLKLLKImPRSLLRLLLVIF---FWWIAFF---PFELFFTDYM 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 246 GEHHWWVYFPA---------------LLLSFVLMVPMLIIA--AKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALA 308
Cdd:cd17313 262 GEEVYHGTSAAsshygagvrmgawglLIFSLAFLIFSLPIGklGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLF 341
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1408604800 309 IVLYFTAFNFLEASLPAMISMSAPAGAK-GSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFfiiaAVMIVWFGISL 386
Cdd:cd17313 342 ALGGIGWATININPYPLVSDYHSESGRGqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVF----PVAAVASFLSL 416
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
64-342 |
8.95e-07 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 50.98 E-value: 8.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 64 LQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGA--VASAILALAADITREQQRPKVMAVIG 141
Cdd:PRK15403 67 LQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSIcfIATVGYVTVQEAFGQTKGIKLMAIIT 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 142 MCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPNPTTKAPAG-DASTNSNKLRSMLRDPQLLRLDVG 220
Cdd:PRK15403 147 SIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPfSAKSVLRDFRNVFRNRLFLTGAAT 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 221 IFLLHLTL-TAVFVSLPFELEAAGLVGEHHWWVYFPalLLSFVLMVPMLIIAAKKKMNKQFFLFA---IALMGLALCVMG 296
Cdd:PRK15403 227 LSLSYIPMmSWVAVSPVILIDAGGMTTSQFAWTQVP--VFGAVIVANAIVARFVKDPTEPRFIWRavpIQLVGLALLIVG 304
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1408604800 297 -FASGSVWL--------FALAIVLYF-TAFNFleaslpAMISMSAPAGAKGSAMGI 342
Cdd:PRK15403 305 nLLWPHVWLwsvlgtslYAFGIGLIFpTLFRF------TLFSNNLPKGTVSASLNM 354
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
26-186 |
1.02e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 50.73 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 26 LGLFMIMPVFAIYGRDLIGYSP---LWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVY 102
Cdd:cd17391 215 LANQSIEPILTLYIRQLMGDASnlaFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPW 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 103 GVAFGRIIQG--TGAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGML 180
Cdd:cd17391 295 QLGILRFLLGlaTGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAI 374
|
....*.
gi 1408604800 181 VVHYIV 186
Cdd:cd17391 375 WSFIFL 380
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-185 |
1.02e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 50.65 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 12 KAAVSLALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSD-RIGRKPVIIAGLGLFCL 90
Cdd:cd17474 198 RGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 91 GSIVAGMADSVYGVAFGRIIQGT--GAVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIF 168
Cdd:cd17474 278 SLLLLGFVPSLALLLIAIVLFGLglGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPF 357
|
170
....*....|....*..
gi 1408604800 169 FVTAALAIVGMLVVHYI 185
Cdd:cd17474 358 LVGAAIALAAAVLLALL 374
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
7-182 |
1.22e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.30 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 7 SKLEQKAAVSLALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLG 86
Cdd:cd17329 195 IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGIL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 87 LFCLGSIVAGMADSVYGVAFGRIIQGTG--AVASAILALAADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGL 164
Cdd:cd17329 275 LFAIGFAVLAFANTLAVLILAMIVLTLGemLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGP 354
|
170
....*....|....*...
gi 1408604800 165 KGIFFVTAALAIVGMLVV 182
Cdd:cd17329 355 GLPWLILAALGLIAAALL 372
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
17-388 |
3.14e-06 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 49.12 E-value: 3.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVI---------IAGLGL 87
Cdd:cd17335 2 LKLFYFFFFAALGSLLPFLSVYLKQL-GLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALlllsllaavLFFLSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 88 FCLGSIVAGMadsVYGVAFGRIIQGTGA--VASAILALAADITREQQRPKVMAVIGMCIGlsfafALVAGPVLAQWIGLK 165
Cdd:cd17335 81 FFVAQIFWLL---LLLVILGAFFSAPVVplVDSITLQYLGEERERYGKQRLWGSIGFGIA-----ALLVGILIDRSSTYK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 166 G--IFFVTAAlaiVGMLVVHYIVPNPTTKAPAGDASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAG 243
Cdd:cd17335 153 NytIAFYVFA---VLMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 244 ----LVGEhhwwvyfpALLLSFVLMVPMLIIAAK--KKMNKQFFLFAIALMGLA-LCVMGFASgSVWLFALAIVLYFTAF 316
Cdd:cd17335 230 gsktLIGL--------LWTVGVVSEIPFFFFSSRliQRFGHVGLLYLGLLAYVVrWLLYSFLE-NPWLVLPIELLHGLTF 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1408604800 317 NFLEASLPAMISMSAPAGAKGSAMGIYSTSQF-AGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGISLGL 388
Cdd:cd17335 301 ALVWAAAVSYASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-195 |
3.24e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 49.11 E-value: 3.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVII---AGLGLFCLGSI 93
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLivfALMALGLLLLA 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 94 VAGMADSVYGVAFGRIIQGTGAVASAILALAADITREQQRPKVMAVIGMCIGL-SFAFALVAGPVLAQWIGLKGIFFVTA 172
Cdd:COG2223 290 LALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLgGFLGPLLFGALLDATGSYTAAFLVFA 369
|
170 180
....*....|....*....|...
gi 1408604800 173 ALAIVGMLVVHYIVPNPTTKAPA 195
Cdd:COG2223 370 VLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
69-388 |
4.92e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 48.35 E-value: 4.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 69 GQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTG---AVASAIlALAADITREQQRPKVMAVIGMCIG 145
Cdd:cd17365 55 GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGlgaAMPNAI-TLVSEYAPARRRSLAVTLMFCGYP 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 146 LSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVhyivpnpttkapagdastnsnklrsmlrdPQLLRLDVGIFLLH 225
Cdd:cd17365 134 LGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLL-----------------------------RGTLLLWVTFFMGL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 226 LTLTAVFVSLPFELEAAGLVGEHHWWVYFpALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLF 305
Cdd:cd17365 185 LLVYLLNSWLPKLMVEAGYSLSQALTITL-LLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 306 ALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYS-QLGSQGLFFIIAAVMIVWFGI 384
Cdd:cd17365 264 YVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAaGLGPESVFLALAIPAALGALA 343
|
....
gi 1408604800 385 SLGL 388
Cdd:cd17365 344 VLLL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
256-382 |
7.50e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.80 E-value: 7.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 256 ALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAfNFLEASLPAMISMSAPAGA 335
Cdd:pfam07690 40 LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGA-GALFPAALALIADWFPPEE 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1408604800 336 KGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWF 382
Cdd:pfam07690 119 RGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA 165
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
43-193 |
8.38e-06 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 48.19 E-value: 8.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 43 IGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGA---VASA 119
Cdd:PRK10504 40 LGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGammVPVG 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1408604800 120 ILALAADITREQQRPKVMAV-----IGMCIGLSFafalvaGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPNPTTKA 193
Cdd:PRK10504 120 RLTVMKIVPREQYMAAMTFVtlpgqVGPLLGPAL------GGLLVEYASWHWIFLINIPVGIIGAIATLMLMPNYTMQT 192
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-329 |
8.87e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 8.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 31 IMPVFAIYgrdlIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRII 110
Cdd:cd17478 18 LLPLLIAK----LGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 111 QGTG-----AVASAILALAADItreqQRPKVMAVIGMCIGLSFAFA-LVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHY 184
Cdd:cd17478 94 AGIGsaafhPEGARLASQAAGG----RRGLAMSIFSVGGNLGFALGpLIAAALVALFGGLGLLILLIIPGLAVALLLLRL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 185 IVPNPTTKAPAGDASTNSNKLRSMLRdpQLLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEhhwwvyFPALLLSFVLM 264
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARSTLKGVWR--ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLV------FAGLLLSLFLF 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 265 V-----PMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGsVWLFALAIVLYFtafnFLEASLPAMISM 329
Cdd:cd17478 242 AgaigtLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG-IWSYILLVLAGF----LLFASFPVTVVL 306
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
41-187 |
1.18e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 47.19 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 41 DLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTG--AVAS 118
Cdd:cd17317 18 DLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTsaGIFT 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1408604800 119 AILALAADITREQQRpkvmAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVP 187
Cdd:cd17317 98 VGFVLGMEIVGPKYR----SFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP 162
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
263-386 |
1.42e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.87 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 263 LMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAfNFLEASLpAMISMSAPAGAKGSAMGI 342
Cdd:cd17391 51 IFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFS-GYVPNAT-ALIASQTPKEKSGWALGT 128
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1408604800 343 YSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGISL 386
Cdd:cd17391 129 LSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTL 172
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
48-187 |
1.51e-05 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 47.41 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 48 LWVgivIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGA---VASAILALA 124
Cdd:PRK14995 44 LWI---IDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAamiVPATLAGIR 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1408604800 125 ADITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVP 187
Cdd:PRK14995 121 ATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVP 183
|
|
| PUCC |
pfam03209 |
PUCC protein; This protein is required for high-level transcription of the PUC operon. |
83-361 |
1.62e-05 |
|
PUCC protein; This protein is required for high-level transcription of the PUC operon.
Pssm-ID: 367394 Cd Length: 401 Bit Score: 46.97 E-value: 1.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 83 AGLGLFCLGSIVAGMADSVYGVafgriiqGTGAVASAILALAADITREQQRPK------VMAVIGMCIGLSFAFALVAGP 156
Cdd:pfam03209 79 ANGAPTWAGLILAAVAFLLYGL-------GVHMSQTPGLALAADLADEERRPKvvgimwVMLLIGIIVSAITVGWLLDDY 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 157 VLAQWI-GLKGIFFVTAALAIVGMLVVHYIVPNPTTKAPAGDASTNSNKLRsMLRDPQLLRLDVGIFLLHLTLTAVFVSL 235
Cdd:pfam03209 152 TPARLIrVIQGVALITFVLNIIALWKIEVGRPSRPAERPEQDPSFLEAWLL-LVAEPQALIFLFFLFLGTLAFFMQDVIL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 236 -PFELEAAGL-VGEHHWWVYFPAL-LLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLY 312
Cdd:pfam03209 231 ePYGGEVFGLtVGETTKLTAFFAGgTLVGFGLAGRVLSPGLGPGRLAGLGCLLGLPSFLALILAGLLGNVALFFAGVLLF 310
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1408604800 313 -FTAFNFLEASLPAMIsMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSL 361
Cdd:pfam03209 311 gLGGGLFTVAALTAMM-DLAPEGRAGTALGAWGAAQATAAGLAGLLGGAL 359
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
21-361 |
2.21e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 46.53 E-value: 2.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 21 FGLRMLGLFMIMPVFAIYG----RDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSD----RIGR-KPVIIAGLGLFCLG 91
Cdd:pfam13347 2 YGSGALAAGIKYAGLATYLlyfyTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDrtrtRWGRrRPWLLLSAIILAVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 92 SI---------VAGMADSVYGVAFGRIIQGTGAVASAIlALAADITRE-QQRPKVMAVIGMCIGL-SFAFALVAGPVLAQ 160
Cdd:pfam13347 82 FIllftppelgRAPLFIWLLATYILLRIAYTFFEIPYW-SLGPELTRDyDERTSLTSYRSFFSVGgGLLAAALAFPLVLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 161 W-------IGLKGIFFVTAALAIVGMLVVHYIVPNPTT-----KAPAGDASTNSNKLRSMLRDPQLLRLdVGIFLLHLTL 228
Cdd:pfam13347 161 LggtglerKGYRIFALIGAVLMLLGVIITAAGTKERVSmrskeDTGQKEAGSLLDMLKEVFRNRAFLIL-LASFLLAALA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 229 TAVFVSLpFELEAAGLVGEHHWWVYFPALLLSFVLMVPMLIIAAKKKMNKQ--FFLFAIALMGLALCVMGFASGSVWLFA 306
Cdd:pfam13347 240 MGVLNGL-LLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKntYILGALITIAGFALALLLGPNNTLLFL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1408604800 307 LAIVLYFTAFNFLEASLPAMISMSAPAG-------AKGSAMGIYS-TSQFAGAFCGGIIAGSL 361
Cdd:pfam13347 319 VLYIIIGFGYGSSFFLPWSMLADVVDYGelrtgkrREGTFFAMWSfISKLATGVGLGVSGLLL 381
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
13-114 |
2.75e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.03 E-value: 2.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 13 AAVSLALVFGLRMLGLFMIMPVFAiygRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGS 92
Cdd:cd17503 182 LGLLLSFLLGLGLFGAMFLLPLYL---QNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGT 258
|
90 100
....*....|....*....|....*
gi 1408604800 93 IV---AGMADSVYGVAFGRIIQGTG 114
Cdd:cd17503 259 LLlafLTPDTSLWLIILPLFIRGLG 283
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
30-192 |
2.78e-05 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 46.03 E-value: 2.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 30 MIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGL------GLFCLGSIVAGMAD--SV 101
Cdd:PRK05122 33 LPLAVLPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLcgcalsGLLYLLAGLLAAWPvlSL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 102 YGVAFGRIIQGTGAVASAILALAADITR--EQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGM 179
Cdd:PRK05122 113 LLLLLGRLLLGIGESLAGTGSILWGIGRvgALHTGRVISWNGIATYGALAIGAPLGVLLYHWGGLAGLGLLIMLLALLGL 192
|
170
....*....|...
gi 1408604800 180 LVVHYIVPNPTTK 192
Cdd:PRK05122 193 LLARPRPAVPPVK 205
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
40-380 |
3.15e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.11 E-value: 3.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 40 RDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRII----QGTGA 115
Cdd:cd17312 30 VEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLnglfQSMGW 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 116 vASAILALAADITREQqRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPNpttkapa 195
Cdd:cd17312 110 -PPCVKLLGNWFSKKE-RGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRD------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 196 gdastnsnklrsmlRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEaaglvgEHHWWVYFPALLLSFVLMVPMLI--IAAK 273
Cdd:cd17312 181 --------------SPPYVWVLSLAYAFVYIVRYACLDWGPLYLY------EVKGYSLIDAGWFSSLYEVGGIAgtILAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 274 KKMNKQF-------FLFAIALMGLALCVMGFASGSVWLFALAIVLyftaFNFLEASLPAMISMSAPA-----GAKGSAMG 341
Cdd:cd17312 241 LLSDKLFggrrapiAVIYMLLMTLSLALFWFFPHNKLLSIVLLFL----IGFFVGGPINLIGGAAAQdigrkEAAGTATG 316
|
330 340 350
....*....|....*....|....*....|....*....
gi 1408604800 342 IYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17312 317 FVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALL 355
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
219-386 |
3.27e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 46.07 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 219 VGIFLLHLTLTAVFVSLPFELEAAGLVGEH--HWW--VYFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCV 294
Cdd:PRK09874 21 LGCFLTGAAFSLVMPFLPLYVEQLGVTGHSalNMWsgLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 295 MGFASgSVWLFALAIVLYFTAFNFLEASlPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFII 374
Cdd:PRK09874 101 MGLAQ-NIWQFLILRALLGLLGGFVPNA-NALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFIT 178
|
170
....*....|..
gi 1408604800 375 AAVMIVWFGISL 386
Cdd:PRK09874 179 ASVLFLCFLVTL 190
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
17-182 |
3.66e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 45.70 E-value: 3.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 17 LALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQ-IPMGQLSDRIGRKPVIIAGLGLFCLGSIVA 95
Cdd:cd17388 211 LLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQaFVTGPIAKRLGEKRAILLGLAADALGFLLL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 96 GMADSVYGVAFGRIIQGTGAVASAilALAADITR---EQQRPKVMAVIGMCIGLsfafALVAGPVLAQWIGLKGIFFVTA 172
Cdd:cd17388 291 AFATQGWMVFPILILLALGGIAGP--ALQGLLSRqvpENEQGELQGVLTSLTSL----TSIIGPLLFTGIFAASPATWPG 364
|
170
....*....|
gi 1408604800 173 ALAIVGMLVV 182
Cdd:cd17388 365 LAWIIGAALY 374
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
30-361 |
3.90e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 45.67 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 30 MIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRI-----GRKPVIIAGLGLFCLGSIVA-------GM 97
Cdd:cd17332 17 IVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTrsrwgRFRPWLLWGAIPLALLFVLLfttpdgsGT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 98 ADSVYGVAFGrIIQGTGAVASAI--LALAADITRE-QQRPK------VMAVIGMCIGLSFAFALVA----GPVLAQWIGL 164
Cdd:cd17332 97 GKLIYALITY-ILLDLLYTLVNIpyTALIPELTDDpEERTSltswrmFFATIGGLLVTVLPPPLVAyfggGNASRGYFLT 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 165 KGIFfvtAALAIVGMLVVHYIVPNPTTKAPAGDASTNSNK-LRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAg 243
Cdd:cd17332 176 ALII---GIIGIILLLICFFGTRERVVPPEEEKSKLPLLKsLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYV- 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 244 LVGEHHWWVYFPALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALCVMGFAS-GSVWLFALAIVLYFTAFNFLEAS 322
Cdd:cd17332 252 LGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpGNLVLILVLAVLAGIGYGGANLL 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1408604800 323 LPAMISMSAPAGAK-------GSAMGIYSTSQ-FAGAFCGGIIAGSL 361
Cdd:cd17332 332 PWAMLADVIDYGELktgkrreGIFYSVMTFFRkLGLALAGALVGLIL 378
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
30-187 |
4.01e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 45.62 E-value: 4.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 30 MIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMA--DSVYGVAFG 107
Cdd:cd17380 16 VNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 108 RIIQGTG-AVA-SAILALAADITREQQRPKVMAVI--GMCIGLsfAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVH 183
Cdd:cd17380 96 RILLGLGeGVHfPSMTSLFSRWVPVSERSRAVSIVtaGSYLGT--LLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWL 173
|
....
gi 1408604800 184 YIVP 187
Cdd:cd17380 174 IYLP 177
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
1-386 |
4.69e-05 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 45.44 E-value: 4.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 1 MDNVALSKLEQKAAVSLALVFGLRMLGLFMI---MPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGR 77
Cdd:PRK12382 1 MTAVSQTETRSSANFSLFRIAFAVFLTYMTVglpLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 78 KPVIIAGL------GLFCLGS--IVAGMADSVYGVAFGRIIQGTGA--VASAILALAADITREQQRPKVMAVIGMCIgls 147
Cdd:PRK12382 81 KRSALQGMlacglaGLAYLLAaiLPVSAPFKFALLVVGRLILGFGEsqLLTGALTWGLGLVGPKHSGKVMSWNGMAM--- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 148 FAfALVAGPVLAQWIGLKGIFFVTAALAIV-GMLVVHYIVPNPTTKAPAGDASTnsnkLRSMLRDPQLLRLDVGIFLLHL 226
Cdd:PRK12382 158 YG-ALAAGAPLGLLLHSHFGFAALALTTMVlPLLAWAFNGTVRKVPAHAGERPS----LWSVVGLIWKPGLGLALQGVGF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 227 TLTAVFVSLPFEleaaglvgEHHW---WVYFPALLLSFVLMVPMLiiaakKKMNKQFFLFAIALMGLALCVMGFA----S 299
Cdd:PRK12382 233 AVIGTFVSLYFA--------SKGWamaGFTLTAFGGAFVLMRVLF-----GWMPDRFGGVKVAIVSLLVETVGLLllwlA 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 300 GSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMI 379
Cdd:PRK12382 300 PTAWVALAGAALTGAGCSLIFPALGVEVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAV 379
|
....*..
gi 1408604800 380 VWFGISL 386
Cdd:PRK12382 380 LGIIVTI 386
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
43-380 |
5.30e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 45.26 E-value: 5.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 43 IGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTGA-VASAIL 121
Cdd:cd17315 29 FGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVgLASVLV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 122 AL-AADITREQQR------PKVMAVIGMCIGLSFAFALVAGPVlAQWIGLKGIFFVTAALAIVGMLVvhyivpnpttkap 194
Cdd:cd17315 109 PLyISEIAPAKIRgalgtlNQLMITFGILLAYLLGLALSLSPP-GWWRLMFALAAVPALLQLLLMFF------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 195 agdastnsnklrsmLRDPQLLRLDVGIFLL-HLT-LTAVFVSLPFELEAAGLVgehhwwvyFPALLLSFVLMVPMLI--- 269
Cdd:cd17315 175 --------------LPESRALLVGVGLQLLqQLTgINAVMYYAPTIFKSAGGG--------TASILASIIVGVVNLLatl 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 270 IAAK---KKMNKQFFLFAIALMGLALCVMGFAS-------GSVWLFALAIVLYFTAFNFLEASLPAMI-SMSAPAGAKGS 338
Cdd:cd17315 233 VAIRlvdKVGRRPLLLIGFAGMAASLLLLAIAFllpalakAAGWLALLGILLYIAAFAMGAGPVPWLLlSEIFPLRIRGK 312
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1408604800 339 AMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIV 380
Cdd:cd17315 313 GMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLL 354
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
45-380 |
6.54e-05 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 45.12 E-value: 6.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 45 YSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYG--VAFGRIIQGT--GAVASAI 120
Cdd:TIGR00894 73 WSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIalVVFCRVIQGLaqGSVSPAT 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 121 LALAADITREQQRPKV--MAVIGMCIGlSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVPNPTTKAPAGDA 198
Cdd:TIGR00894 153 HKIIVKWAPPKERSRLlgMSTSGFQLG-TFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 199 STNSNKLRSmlrdpqlLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGE--------------HHWWVYFPALLLSFVLM 264
Cdd:TIGR00894 232 FEKKYINSS-------LQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHfwlytilptylptfISWVLRVSGKENGLLSS 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 265 VPMLI----------IAAKKKMNKQF------FLF-AIALMGLALCVMgFASGSVWLFALAIVLYFTAFNFLEASLPAMI 327
Cdd:TIGR00894 305 LPYLFawlcsifagyLADFLKSSKTLsltaarKIFnGIGGLGPGIFAY-ALPYLSAAFYLTIIILTLANAVSSGPLAGVL 383
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1408604800 328 SMS---APAGAkgsamGIYSTSQFAGAFCGGIIAGSLYSQLGSQG-------LFFIIAAVMIV 380
Cdd:TIGR00894 384 INSldlAPRFL-----GFIKGITGLPGFIGGLIASTLAGNILSQDsknvwliVFLIMAFVNIL 441
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
51-187 |
7.02e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.92 E-value: 7.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 51 GIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGL---GLFCLGSIVAGMAdSVYGVAFGRIIQG--TGAVASAILALAA 125
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSIlitALLTLLTPLAARG-GYGALIVLRILQGlaQGVTFPAMHALWA 137
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1408604800 126 DITREQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYIVP 187
Cdd:cd17318 138 KWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL 199
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
48-384 |
7.08e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 44.96 E-value: 7.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 48 LWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMAD---SVYGVAFGRIIQGTGAVASAILA-- 122
Cdd:pfam00083 46 VLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLApm 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 123 LAADITREQQR------PKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVV----HYIV------ 186
Cdd:pfam00083 126 YISEIAPKKLRgalgslYQLAITFGILLAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLpespRWLVekgrle 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 187 --------PNPTTKA---------------PAGDASTNSNKLRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLPFELEAAG 243
Cdd:pfam00083 206 earevlakLRGVPDVdreldeikdsleagqEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLG 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 244 LVGEHHWWVYFPALLLSFVLMVPMLIiaaKKKMNKQFFLFAIALMGLALCVMG-----FASGSVWLFALAIV---LYFTA 315
Cdd:pfam00083 286 LSDSFLVTIIVGVVNFVFTFIAIFLV---DRFGRRPLLLLGAAGMAICFVILGivallGVSKSDWAGIVAIVfiaLFIAF 362
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 316 FNFLEASLPAMI-SMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGI 384
Cdd:pfam00083 363 FAMGWGPVPWVIvSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIF 432
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
278-388 |
8.54e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.49 E-value: 8.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 278 KQFFLFAIALMGLALCVMGFASgSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGII 357
Cdd:cd17325 61 KRLLLLGLLLLAVSTLLFAFAT-SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLL 139
|
90 100 110
....*....|....*....|....*....|.
gi 1408604800 358 AGSLYSQLGSQGLFFIIAAVMIVWFGISLGL 388
Cdd:cd17325 140 GGLLADALGYRAPFLVCAALALLALVLALLL 170
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
214-386 |
9.93e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.19 E-value: 9.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 214 LLRLDVGIFLLHLTLTAVFVSLPFELEAAGLVGEHHWWVYFpALLLSFVLMVPMLIIAAKKKMNKQFFLFAIALMGLALC 293
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVT-AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 294 VMGFASgSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFI 373
Cdd:COG2814 91 LCALAP-SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170
....*....|...
gi 1408604800 374 IAAVMIVWFGISL 386
Cdd:COG2814 170 NAVLALLALLLLL 182
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
9-182 |
4.46e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.15 E-value: 4.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 9 LEQKAAVSLALVFGLRMLGLFMIMPVFAIYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLF 88
Cdd:cd17324 195 LRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLA 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 89 CLGSIVAGMADSVYGVAFGRIIQGTGAVASAILALAADITR-EQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGI 167
Cdd:cd17324 275 AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLaPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGV 354
|
170
....*....|....*
gi 1408604800 168 FFVTAALAIVGMLVV 182
Cdd:cd17324 355 GWVGAALLLLALLLA 369
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-181 |
4.66e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.20 E-value: 4.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 27 GLFMIMPVfaiYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMA--DSVYGV 104
Cdd:cd17316 195 GLTTFLPT---YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLL 271
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1408604800 105 AFGRIIQG--TGAVASAILALAADITREQQRpkvMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLV 181
Cdd:cd17316 272 LLLLFILSffVGGVWGALYAYLAELFPTEVR---ATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
281-380 |
5.24e-04 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 42.11 E-value: 5.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 281 FLFAIALMGLALCVMGFASG--------SVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAF 352
Cdd:COG3104 353 FALGLLLLGLGFLVMALAALlagaggkvSPLWLVLAYLLLTIGELCLSPVGLSMITKLAPARFAGQMMGLWFLATALGNL 432
|
90 100
....*....|....*....|....*...
gi 1408604800 353 CGGIIAGsLYSQLGSQGLFFIIAAVMIV 380
Cdd:COG3104 433 LAGLLAG-LYAVPGYTAYFLLLGGIALV 459
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
30-236 |
5.52e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 42.23 E-value: 5.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 30 MIMPVFAIYGRDLiGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRI 109
Cdd:PRK15402 31 MIQPGMLAVVEDF-NAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 110 IQGT-----GAVASAILALAADitrEQQRPKVMAVIGMCIGLSFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHY 184
Cdd:PRK15402 110 LQGIglcfiGAVGYAAIQESFE---EADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWR 186
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1408604800 185 IVPNPTTkapagdASTNSNKLRSMLRDPQLLRLDvGIFLLhLTLTAVFVSLP 236
Cdd:PRK15402 187 AMPETAG------RVGEKLSLKELGRDYKLVLKN-RRFVA-GALALGLVSLP 230
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
57-182 |
6.68e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.84 E-value: 6.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 57 YGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVafgRIIQGTGAVASAIL-----ALAADITREQ 131
Cdd:cd17313 290 FSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVA---LVLFALGGIGWATIninpyPLVSDYHSES 366
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1408604800 132 QRPkvmavIGMCIGL----SFAFALVAGPVLAQWIGLK--GIFFVTAALAIVGMLVV 182
Cdd:cd17313 367 GRG-----QGTDTGLlnlaISLAQILVSLLAGPIIDVKgyGTVFPVAAVASFLSLVG 418
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
69-189 |
8.40e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 8.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 69 GQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQ--GTGAVASAILALAADITREQQRPKVMAV--IGMCI 144
Cdd:TIGR00895 73 GPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAglGLGGLMPNLNALVSEYAPKRFRGTAVGLmfCGYPI 152
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1408604800 145 GLSFAfALVAGPVLAQwIGLKGIFFVTAALAIVGMLVVHYIVPNP 189
Cdd:TIGR00895 153 GAAVG-GFLAGWLIPV-FGWRSLFYVGGIAPLLLLLLLMRFLPES 195
|
|
| MFS_SLC46A1_PCFT |
cd17449 |
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ... |
58-194 |
1.33e-03 |
|
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341007 [Multi-domain] Cd Length: 425 Bit Score: 40.95 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 58 GLTQAILqipMGQLSDRIGRKPV-IIAGLGLFCLGSI---VAGMADSVYGVAFGRIIQGTGAVASAILA----LAADITR 129
Cdd:cd17449 78 GLFSVTL---LGPWSDSVGRRPVlILPSLGLALQAAVyllVMYLQLHVAYFLIGRILSGLLGDFNGILAgcfaYVADVSD 154
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1408604800 130 EQQRPKVMAVIGMCIGLSFAFALVAGpvlAQWIGLKGI---FFVTAALAIVGMLVVHYIVPNPTTKAP 194
Cdd:cd17449 155 RRSRTFRVAVLEACLGLAGMLASIIG---GQWRKAQGYinpFWLVLALNLAAALYAAFCVGESVKEPK 219
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
281-386 |
1.34e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 41.02 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 281 FLFAIALMGLALCVMGFASG--------SVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAF 352
Cdd:cd17346 274 FALGLLLLGLSFLLMVLAASfaggsgkvSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMGLWFLASALGNI 353
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1408604800 353 CGGIIAGSLYS------QLGSQGLFFIIAAVMIVWFGISL 386
Cdd:cd17346 354 LAGYLAGFYAQpkdplaSALVYTDYFGLIGVIALVAGIIL 393
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
278-396 |
1.51e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 278 KQFFLFAIALMGLALCVMGFAsGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGII 357
Cdd:cd17489 61 KRLLLIGLLIFALATLLYLLA-TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPAL 139
|
90 100 110
....*....|....*....|....*....|....*....
gi 1408604800 358 AGSLYSQLGSQGLFFIIAAVMIVWFGISLGLENVGQVKA 396
Cdd:cd17489 140 GLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAA 178
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
15-162 |
1.54e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 40.80 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 15 VSLALVFGLRMLGLFMIMPVfaiYGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIV 94
Cdd:cd17366 199 IGLVLVFNVTNYMLLSYMPS---YLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVP 275
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1408604800 95 AGM---ADSVYGVAFGRIIQG------TGAVASAILALAADITREQqrpkvmaviGMCIGLSFAFALVAG--PVLAQWI 162
Cdd:cd17366 276 AFLlmnSGSIAAIFIGLLVLGlllscyTATMASTLPALFPTHVRYS---------ALAIAFNISVSLFGGttPLVASWL 345
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
40-120 |
1.74e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.63 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 40 RDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTG-AVAS 118
Cdd:cd17359 28 QTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAvGGAS 107
|
..
gi 1408604800 119 AI 120
Cdd:cd17359 108 AL 109
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
13-173 |
1.74e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.62 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 13 AAVSLALVFGLRMLGLFMIMPVFAIYGRdliGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGS 92
Cdd:cd17321 172 GAVLAAFLLGAALGGLLFLLPLYLQGVL---GYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 93 I---VAGMADSVYGVAFGRIIQ--GTGAVASAILALAADITREQQRPKVMAV------IGMCIGLSFAFALVAGPVLAQW 161
Cdd:cd17321 249 LllaLLGADSSVWLLLPGLVLLglGLGLFATPLTNAALSSVPKEKAGAASGIlntarqLGGALGVALLGALLTAGLSANL 328
|
170
....*....|..
gi 1408604800 162 IGLKGIFFVTAA 173
Cdd:cd17321 329 GDSGVAALLSAA 340
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
69-170 |
2.81e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 39.95 E-value: 2.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 69 GQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGT--GAVASAILALAADITREQQRPKvmAVIGMCIGL 146
Cdd:PRK11551 71 GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVglGGALPNLIALTSEAVGPRLRGT--AVSLMYCGV 148
|
90 100
....*....|....*....|....*.
gi 1408604800 147 SF--AFALVAGPVLAQWIGLKGIFFV 170
Cdd:PRK11551 149 PFggALASVIGVLAAGDAAWRHIFYV 174
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
69-123 |
2.97e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 39.56 E-value: 2.97e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1408604800 69 GQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTG-AVASAILAL 123
Cdd:cd17360 56 GWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGvGIASMTVPL 111
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
45-224 |
3.13e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 40.04 E-value: 3.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 45 YSPLWVgivigaygLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQG--TGAVASAILA 122
Cdd:pfam06609 83 FSTLWT--------MGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGvaAGPAGASPLF 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 123 LAADITREQQRPKVMAVIGMCIGLSfafalVAGPVLAQWIGLKG-------IFFVTAALAIVGMLVVHYivpnpttkaPA 195
Cdd:pfam06609 155 IGELMSNKTKFLGLLIVSAPTIAMN-----GAGPYFGQRLAIQGnwrwifyIYIIMSAIAVLLIIIWYH---------PP 220
|
170 180 190
....*....|....*....|....*....|
gi 1408604800 196 GDASTNSNKLRSmlRDpQLLRLD-VGIFLL 224
Cdd:pfam06609 221 SFAQLHGKKARK--RD-ELAKLDwIGIFLV 247
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
51-344 |
3.17e-03 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 39.71 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 51 GIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLgSIVAGMADSVYGVAFGRIIQGTGAVASAILALAADITRE 130
Cdd:cd17387 39 GLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCA-PIPLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 131 QQRPKVMAVIGMciglSFAFALVAGPVLAQWI-GLKGIFFVTAALAIVGMLVVHYI---VPN--PTTKAPAGDASTNSNK 204
Cdd:cd17387 118 EERSTAYGLVSA----TFAASLVTSPALGAYLsESYGDNLVVLVATIVALLDICFIllaVPEslPEKMRPASWGAPISWE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 205 -------LRSMLRDPQLLRLDVGIFLLHLTLTAVFVSLP--------FELEAA----GLVGehhwwvyfpalLLSFVLMV 265
Cdd:cd17387 194 qadpfasLRKVGKDKTVLLICITVFLSYLPEAGQYSSFFvylkqvmgFEYEEVaafiAVVG-----------ILSITAQT 262
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1408604800 266 PMLIIAAKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFleASLPAMISMSAPAGAKGSAMGIYS 344
Cdd:cd17387 263 LLLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITF--PAISALVSRYADPDQQGAVQGMIT 339
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
44-386 |
3.86e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 39.41 E-value: 3.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 44 GYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIV---AGMADSVYGVAF-GRIIQGTG--AVA 117
Cdd:cd17337 28 GFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIWLVFEVLflaFGLPSHNYPLMLlTYGLRGFGypLFA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 118 SAILALAADITREQQRPKVMAVIGmciglsFAFAL---VAGPVLAQW----IGLKGIFFVTAALAIVGMLVVHYIVPNPT 190
Cdd:cd17337 108 YSFLVWITYRTPAERLGSAVGWFW------FAFTGglpVLGSYLASFtipvIGEIGTLWLSLVFVALGGLIALFLVRDRT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 191 TKAPAGDASTNsnKLRSMLRDPQLLRLDVGIFLL-------HLTLTAVFVSLPFELEAAGLVGEHHWwvyfpALLLSFVL 263
Cdd:cd17337 182 GEQPLANPSEE--PLKELLSGITILFRNPKIAIGgivriinTLSQFGFPVFMPLYFTDTGGFSTSQW-----LQIWGIIF 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 264 MVPML------IIAAKKKMNKQFFLFAIALMGLALCVMGF----ASGSVWLFALAIVLY---FTAFnfleASLPAMISMS 330
Cdd:cd17337 255 LVNIFfnlifgILGDKIGWRRTVRWFGGVGCAISTLLFYYvpqlFGHNYWAALIAAILFgigLAGF----VPLSALMPSL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1408604800 331 APaGAKGSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGISL 386
Cdd:cd17337 331 AP-EHKGAAMSILNLGAGLSNFVGPAIVTLFLGSFGAGGVVWIFAGLYLLSAVLTL 385
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
16-182 |
4.40e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 39.20 E-value: 4.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 16 SLALVFGLRMLGLfMIMPVFAIYGRDLI----GYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLG 91
Cdd:cd17367 224 ELLLVVGLTAGGT-LAFYTWTTYLQKFLvntaGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLA 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 92 SIV----AGMADSVYgVAFGRIIQGtGAVASAILALAADITREQQRPKVMAvIGMCIGLSFAFALVAG--PVLAQW---I 162
Cdd:cd17367 303 TVPllsaLDHTDSPY-TAFALVLVG-LVFLSGYTSINAVVKAELFPTHVRA-LGVGLPYALAVAIFGGtaPYVALWlksI 379
|
170 180
....*....|....*....|.
gi 1408604800 163 GLKGIFFV-TAALAIVGMLVV 182
Cdd:cd17367 380 GHEWVFFWyVAGLIAISLVVY 400
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
59-386 |
6.79e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 6.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 59 LTQAILQIPMGQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYGV--AFGrIIQGTGAVASAILALAADITREQQRPkv 136
Cdd:cd17353 49 VFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLflGYG-VLGGIGAGIGYITPVSTAVKWFPDKR-- 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 137 maviGMCIGLSFA----FALVAGPVLAQWIGLKGI---FFVTAALAIVGMLVVHYIVPNP---------TTKAPAGDAST 200
Cdd:cd17353 126 ----GLATGIVIAgfglGSLIFSPLIAYLINTVGVpttFLILGIIFLIIIVIGAFLIRDPpkgwvppgvDPLANNAENSP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 201 NSNKLRSMLRDPQLlrldvgiFLLHLTLTAVFVSLPFELEAAGLVGEHhwWVYFPALLLSFVLMV---------PMLIIA 271
Cdd:cd17353 202 RDYTPREMLRTPTF-------WLLWLMFFLNATAGLMLIGQAKPIGQE--FAGLDAGIAALAVSIlsifngggrPFWGWL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 272 AKKKMNKQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAFNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGA 351
Cdd:cd17353 273 SDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGG 352
|
330 340 350
....*....|....*....|....*....|....*
gi 1408604800 352 FCGGIIAGSLYSQLGSQGLFFIIAAVMIVWFGISL 386
Cdd:cd17353 353 LIGPIIAAYVLYTGGYNAAFIIAAALSLVALALAL 387
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
280-422 |
6.81e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.69 E-value: 6.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 280 FFLFAIALMGLALCVMGFASGSVWLFALAIVLYF-TAFNFLEASlpAMISMSAPaGAKGSAMGIYSTSQFAGAFCGGIIA 358
Cdd:cd17478 63 LLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIgSAAFHPEGA--RLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIA 139
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1408604800 359 GSLYSQLGSQGLFFIIAAVMIVWFGISLGLENVGQVKAHTIAVTIANQREAELIAEKLISLSGI 422
Cdd:cd17478 140 AALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLII 203
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
44-185 |
6.90e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.71 E-value: 6.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 44 GYSPLWVGIVIGAYGLTQAILQIPMGQLSDRI---GRKPVIIAGLGLFCLGSIVAGMADSVYGVAFGRIIQGTG--AVAS 118
Cdd:cd17319 211 GFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGigAASP 290
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1408604800 119 AILALAADITREQQRPKVMAVIGMCIGL-SFAFALVAGPVLAQWIGLKGIFFVTAALAIVGMLVVHYI 185
Cdd:cd17319 291 VFWSLPADLLPGEAAATAGGLINSGGNLgGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
278-389 |
7.17e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 38.25 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 278 KQFFLFAIALMGLALCVMGFASGSVWLFALAIVLYFTAfNFLEASLPAMISMSAPAGAKGSAMGIYSTSQFAGAFCGGII 357
Cdd:COG0477 79 KRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGA-GGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLL 157
|
90 100 110
....*....|....*....|....*....|..
gi 1408604800 358 AGSLYSQLGSQGLFFIIAAVMIVWFGISLGLE 389
Cdd:COG0477 158 GGLLVAALGWRWIFLINAPLGLLALVLRLRLP 189
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
16-96 |
7.71e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.66 E-value: 7.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 16 SLALVFGLRML--GLFMIMPVFAI-YGRDLIGYSPLWVGIVIGAYGLTQAILQIPMGQLSDRIGRKPVIIAGlglfCLGS 92
Cdd:cd17369 229 ALLLAIGLRLAenVLFYLFTTFALsYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAG----ALLA 304
|
....
gi 1408604800 93 IVAG 96
Cdd:cd17369 305 ALFA 308
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
69-389 |
7.73e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 7.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 69 GQLSDRIGRKPVIIAGLGLFCLGSIVAGMADSVYG--VAFGrIIQGTG---AVASAILALAADITREQQRPKVMAVIGMC 143
Cdd:cd17352 59 SALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQlyLTYG-VLGGLGlglIYSPAIVIVGQYFEKKRGLATGIAVAGSG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 144 IGlSFAFALVAGpVLAQWIGLKGIFFVTAALAIVGMLVVHYIVpnpttkapagdastnsnklrsMLRDPQLLRLDVGIFL 223
Cdd:cd17352 138 VG-TFVFPPLLR-YLLDNYGWRGALLILGGLCLNLCVCGLLLR---------------------LLKDPTFVLLALGVSF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 224 LHLTLTAVFVSLPFELEaaglvgEHHWWVYFPALLLSFV-----LMVPML-IIAAKKKMNKQ-FFLFAIALMGLALCVMG 296
Cdd:cd17352 195 AMLGFFVPFVYLPSYAK------SLGIDESDAAFLLSIIgisdiVGRILLgLLADKPRIGRLyLYIFTLLILGLSLLAFP 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408604800 297 FASGSVwlfalAIVLYFTAFNFLEASLPAMISMSAPAGAK----GSAMGIYSTSQFAGAFCGGIIAGSLYSQLGSQGLFF 372
Cdd:cd17352 269 LATTYV-----GLIVFSVLFGFCSGSYSSLTPVILADLVGleklSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAF 343
|
330
....*....|....*..
gi 1408604800 373 IIAAVMIVWFGISLGLE 389
Cdd:cd17352 344 YFCGACLLLSGVLLFLL 360
|
|
| |
