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Conserved domains on  [gi|1408390155|ref|WP_111642558|]
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sialate O-acetylesterase [Marinimicrobium alkaliphilum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LacZ super family cl43822
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];
266-377 2.35e-14

Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG3250:

Pssm-ID: 442481 [Multi-domain]  Cd Length: 638  Bit Score: 76.34  E-value: 2.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408390155 266 ARSDYDHSDWDTIELPRFWS-----------DPEEPVNGVWWLRKTIEVPDSWAGKPAFLNL-GTMTDADAtFLNGELVG 333
Cdd:COG3250    14 AKPDFDDSGWDPITVPGDWEldlyglpdpfvGPWYLYNGVGWYRRTFTVPASWKGKRVFLHFeGVDTAAEV-WVNGKKVG 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1408390155 334 RTWYQYPPRWYRLPEgVLKAGTNTLTVRLVSESgRPGFWEDKDY 377
Cdd:COG3250    93 YHEGGFTPFEFDITD-YLKPGENVLAVRVDNPS-DGSYLEGQDW 134
SASA super family cl04187
Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this ...
 402-527 6.16e-11

Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in UniProtKB:P70665.


The actual alignment was detected with superfamily member pfam03629:

Pssm-ID: 427409  Cd Length: 227  Bit Score: 62.61  E-value: 6.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408390155 402 AKGGSTFIRWKPLG-LYNGMI----APLHKVPFTGVIWYQGESNAGRYGE---YAELFETLIEDWRGHWNNDELPFLFVQ 473
Cdd:pfam03629  89 AVGGTSIEEWARGGlLYQEMVrrakAALKGGEIKGILWYQGESDTSDEEDaaaYKEKLEKLITDLRDDLGLPDLPIIQVQ 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1408390155 474 LAnymaaheQPTDSHWARLREAQkQTLGVAHTGMAVAIDVGEWNDIHPLDKASV 527
Cdd:pfam03629 169 LA-------SGEGPYEEVVREAQ-LGIKLPNVTVVDAKGLPLKDDNLHLTTESQ 214
Ca_tandemer NF033510
Ca2+-stabilized adhesin repeat; This repeat is found in proteins such as the ...
 50-92 1.49e-03

Ca2+-stabilized adhesin repeat; This repeat is found in proteins such as the biofilm-associated protein Bap of Acinetobacter baumannii (which can exceed 8000 amino acids in length), the calcium-stabilized ice-binding adhesin of the Antarctic bacterium Marinomonas primoryensis, and the giant calcium-binding adhesin SiiE of Salmonella enterica.


:

Pssm-ID: 411149 [Multi-domain]  Cd Length: 97  Bit Score: 38.43  E-value: 1.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1408390155  50 ADPGEAVRVEFRGERYTTEADAEGHWEVTLPPQG----AGGPEQLVV 92
Cdd:NF033510   41 AEAGQTVTVTLNGKTYTATVDADGSWSVTVPAADlaalADGTYTVTV 87
 
Name Accession Description Interval E-value
LacZ COG3250
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];
266-377 2.35e-14

Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];


Pssm-ID: 442481 [Multi-domain]  Cd Length: 638  Bit Score: 76.34  E-value: 2.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408390155 266 ARSDYDHSDWDTIELPRFWS-----------DPEEPVNGVWWLRKTIEVPDSWAGKPAFLNL-GTMTDADAtFLNGELVG 333
Cdd:COG3250    14 AKPDFDDSGWDPITVPGDWEldlyglpdpfvGPWYLYNGVGWYRRTFTVPASWKGKRVFLHFeGVDTAAEV-WVNGKKVG 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1408390155 334 RTWYQYPPRWYRLPEgVLKAGTNTLTVRLVSESgRPGFWEDKDY 377
Cdd:COG3250    93 YHEGGFTPFEFDITD-YLKPGENVLAVRVDNPS-DGSYLEGQDW 134
SASA pfam03629
Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this ...
 402-527 6.16e-11

Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in UniProtKB:P70665.


Pssm-ID: 427409  Cd Length: 227  Bit Score: 62.61  E-value: 6.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408390155 402 AKGGSTFIRWKPLG-LYNGMI----APLHKVPFTGVIWYQGESNAGRYGE---YAELFETLIEDWRGHWNNDELPFLFVQ 473
Cdd:pfam03629  89 AVGGTSIEEWARGGlLYQEMVrrakAALKGGEIKGILWYQGESDTSDEEDaaaYKEKLEKLITDLRDDLGLPDLPIIQVQ 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1408390155 474 LAnymaaheQPTDSHWARLREAQkQTLGVAHTGMAVAIDVGEWNDIHPLDKASV 527
Cdd:pfam03629 169 LA-------SGEGPYEEVVREAQ-LGIKLPNVTVVDAKGLPLKDDNLHLTTESQ 214
Ca_tandemer NF033510
Ca2+-stabilized adhesin repeat; This repeat is found in proteins such as the ...
 50-92 1.49e-03

Ca2+-stabilized adhesin repeat; This repeat is found in proteins such as the biofilm-associated protein Bap of Acinetobacter baumannii (which can exceed 8000 amino acids in length), the calcium-stabilized ice-binding adhesin of the Antarctic bacterium Marinomonas primoryensis, and the giant calcium-binding adhesin SiiE of Salmonella enterica.


Pssm-ID: 411149 [Multi-domain]  Cd Length: 97  Bit Score: 38.43  E-value: 1.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1408390155  50 ADPGEAVRVEFRGERYTTEADAEGHWEVTLPPQG----AGGPEQLVV 92
Cdd:NF033510   41 AEAGQTVTVTLNGKTYTATVDADGSWSVTVPAADlaalADGTYTVTV 87
Glyco_hydro_2_N pfam02837
Glycosyl hydrolases family 2, sugar binding domain; This family contains beta-galactosidase, ...
 271-392 1.70e-03

Glycosyl hydrolases family 2, sugar binding domain; This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities and has a jelly-roll fold. The domain binds the sugar moiety during the sugar-hydrolysis reaction.


Pssm-ID: 397120 [Multi-domain]  Cd Length: 169  Bit Score: 39.92  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408390155 271 DHSDWDTIELPRFWSDPEEP-VNGVWWLRKTIEVPDSWAGKPAFLNLGTMTDADATFLNGELVGRTWYQYPPRWYRLpEG 349
Cdd:pfam02837  42 DQPIYTNVEYPIDFADPFIPtYNGTGWYQRTFFIPSKWAGQRIRLRFDGVTHYGEVWVNGQWVGEHQGGYTPFEFDL-TP 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1408390155 350 VLKAGTNTLTVRLVSesgrpgfWEDKDYELEwqgESIDLTGEW 392
Cdd:pfam02837 121 YVIAGKNRIAVKVLN-------WSDG*YIED---QNGKYFHDF 153
 
Name Accession Description Interval E-value
LacZ COG3250
Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];
266-377 2.35e-14

Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism];


Pssm-ID: 442481 [Multi-domain]  Cd Length: 638  Bit Score: 76.34  E-value: 2.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408390155 266 ARSDYDHSDWDTIELPRFWS-----------DPEEPVNGVWWLRKTIEVPDSWAGKPAFLNL-GTMTDADAtFLNGELVG 333
Cdd:COG3250    14 AKPDFDDSGWDPITVPGDWEldlyglpdpfvGPWYLYNGVGWYRRTFTVPASWKGKRVFLHFeGVDTAAEV-WVNGKKVG 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1408390155 334 RTWYQYPPRWYRLPEgVLKAGTNTLTVRLVSESgRPGFWEDKDY 377
Cdd:COG3250    93 YHEGGFTPFEFDITD-YLKPGENVLAVRVDNPS-DGSYLEGQDW 134
SASA pfam03629
Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this ...
 402-527 6.16e-11

Carbohydrate esterase, sialic acid-specific acetylesterase; The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in UniProtKB:P70665.


Pssm-ID: 427409  Cd Length: 227  Bit Score: 62.61  E-value: 6.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408390155 402 AKGGSTFIRWKPLG-LYNGMI----APLHKVPFTGVIWYQGESNAGRYGE---YAELFETLIEDWRGHWNNDELPFLFVQ 473
Cdd:pfam03629  89 AVGGTSIEEWARGGlLYQEMVrrakAALKGGEIKGILWYQGESDTSDEEDaaaYKEKLEKLITDLRDDLGLPDLPIIQVQ 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1408390155 474 LAnymaaheQPTDSHWARLREAQkQTLGVAHTGMAVAIDVGEWNDIHPLDKASV 527
Cdd:pfam03629 169 LA-------SGEGPYEEVVREAQ-LGIKLPNVTVVDAKGLPLKDDNLHLTTESQ 214
Ca_tandemer NF033510
Ca2+-stabilized adhesin repeat; This repeat is found in proteins such as the ...
 50-92 1.49e-03

Ca2+-stabilized adhesin repeat; This repeat is found in proteins such as the biofilm-associated protein Bap of Acinetobacter baumannii (which can exceed 8000 amino acids in length), the calcium-stabilized ice-binding adhesin of the Antarctic bacterium Marinomonas primoryensis, and the giant calcium-binding adhesin SiiE of Salmonella enterica.


Pssm-ID: 411149 [Multi-domain]  Cd Length: 97  Bit Score: 38.43  E-value: 1.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1408390155  50 ADPGEAVRVEFRGERYTTEADAEGHWEVTLPPQG----AGGPEQLVV 92
Cdd:NF033510   41 AEAGQTVTVTLNGKTYTATVDADGSWSVTVPAADlaalADGTYTVTV 87
Glyco_hydro_2_N pfam02837
Glycosyl hydrolases family 2, sugar binding domain; This family contains beta-galactosidase, ...
 271-392 1.70e-03

Glycosyl hydrolases family 2, sugar binding domain; This family contains beta-galactosidase, beta-mannosidase and beta-glucuronidase activities and has a jelly-roll fold. The domain binds the sugar moiety during the sugar-hydrolysis reaction.


Pssm-ID: 397120 [Multi-domain]  Cd Length: 169  Bit Score: 39.92  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1408390155 271 DHSDWDTIELPRFWSDPEEP-VNGVWWLRKTIEVPDSWAGKPAFLNLGTMTDADATFLNGELVGRTWYQYPPRWYRLpEG 349
Cdd:pfam02837  42 DQPIYTNVEYPIDFADPFIPtYNGTGWYQRTFFIPSKWAGQRIRLRFDGVTHYGEVWVNGQWVGEHQGGYTPFEFDL-TP 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1408390155 350 VLKAGTNTLTVRLVSesgrpgfWEDKDYELEwqgESIDLTGEW 392
Cdd:pfam02837 121 YVIAGKNRIAVKVLN-------WSDG*YIED---QNGKYFHDF 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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