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Conserved domains on  [gi|1406955314|gb|AWV90167|]
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hypothetical protein DN745_12825 [Bradymonas sediminis]

Protein Classification

Fur family transcriptional regulator( domain architecture ID 10002362)

Fur (ferric uptake regulator) family transcriptional regulator such as metal ion uptake regulator proteins, which are responsible for controlling the intracellular concentration of iron in many bacteria

CATH:  3.30.1490.190|1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677|GO:0046872
PubMed:  17216355|24106689

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
71-212 2.24e-32

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


:

Pssm-ID: 440498  Cd Length: 140  Bit Score: 113.89  E-value: 2.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1406955314  71 LDESLQRLKDAGFRLTPQRRAILEIFHDGAGHLTPQQVFATLDDVVPSLSLATVYNTLELLEEIGLLTRVTAHDGQTYFD 150
Cdd:COG0735     4 LEEAEELLREAGLRLTPQRLAILELLLESDRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFGGGKARYE 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1406955314 151 PTVV-PHHHALCDGCGDIFDVFLKPgaLDDLIADAEAFEGanpdFRVTQATVWLRGRCKSCQH 212
Cdd:COG0735    84 LNEGdHHHHLICTKCGKVIELDDDE--IEELLEELAEPHG----FEIESHELEIYGLCPDCQK 140
 
Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
71-212 2.24e-32

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 113.89  E-value: 2.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1406955314  71 LDESLQRLKDAGFRLTPQRRAILEIFHDGAGHLTPQQVFATLDDVVPSLSLATVYNTLELLEEIGLLTRVTAHDGQTYFD 150
Cdd:COG0735     4 LEEAEELLREAGLRLTPQRLAILELLLESDRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFGGGKARYE 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1406955314 151 PTVV-PHHHALCDGCGDIFDVFLKPgaLDDLIADAEAFEGanpdFRVTQATVWLRGRCKSCQH 212
Cdd:COG0735    84 LNEGdHHHHLICTKCGKVIELDDDE--IEELLEELAEPHG----FEIESHELEIYGLCPDCQK 140
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 87-207 2.07e-23

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 90.33  E-value: 2.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1406955314  87 PQRRAILEIFHDGAGHLTPQQVFATLDDVVPSLSLATVYNTLELLEEIGLLTRVTAHDGQTYFDPTVV-PHHHALCDGCG 165
Cdd:cd07153     1 PQRLAILEVLLESDGHLTAEEIYERLRKKGPSISLATVYRTLELLEEAGLVREIELGDGKARYELNTDeHHHHLICTKCG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1406955314 166 DIFDVFLKPgaLDDLIADAEAFEGanpdFRVTQATVWLRGRC 207
Cdd:cd07153    81 KVIDFEDCP--LEELLEELAAKTG----FKITSHRLELYGIC 116
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 81-192 6.56e-16

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 70.74  E-value: 6.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1406955314  81 AGFRLTPQRRAILEIF-HDGAGHLTPQQVFATLDDVVPSLSLATVYNTLELLEEIGLLTRVTAHDGQTYFDPTVVPHH-H 158
Cdd:pfam01475   2 AGLKLTPQRLKILEVLqKSDKEHLSAEEIYKELREEDPNISLATVYRTLNLLEEAGLVKRLEFDGGESRFELNTGHHHdH 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1406955314 159 ALCDGCGDIFDVFLKPgaLDDLIADAEAFEGANP 192
Cdd:pfam01475  82 LICEDCGKVIEFKDDE--IEKRQEEIAKKHGFKL 113
fur PRK09462
ferric uptake regulator; Provisional
 76-212 4.37e-06

ferric uptake regulator; Provisional


Pssm-ID: 236527  Cd Length: 148  Bit Score: 44.72  E-value: 4.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1406955314  76 QRLKDAGFRLTPQRRAILEIFHDGAG-HLTPQQVFATLDDVVPSLSLATVYNTLELLEEIGLLTRVTAHDGQTYFDPTVV 154
Cdd:PRK09462    6 TALKKAGLKVTLPRLKILEVLQEPDNhHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFELTQQ 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1406955314 155 PHH-HALCDGCGDIFDVflkpgaLDDLIADAEAFEGANPDFRVTQATVWLRGRCK--SCQH 212
Cdd:PRK09462   86 HHHdHLICLDCGKVIEF------SDDSIEARQREIAAKHGIKLTNHSLYLYGHCAegDCRE 140
 
Name Accession Description Interval E-value
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
71-212 2.24e-32

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 113.89  E-value: 2.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1406955314  71 LDESLQRLKDAGFRLTPQRRAILEIFHDGAGHLTPQQVFATLDDVVPSLSLATVYNTLELLEEIGLLTRVTAHDGQTYFD 150
Cdd:COG0735     4 LEEAEELLREAGLRLTPQRLAILELLLESDRHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFGGGKARYE 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1406955314 151 PTVV-PHHHALCDGCGDIFDVFLKPgaLDDLIADAEAFEGanpdFRVTQATVWLRGRCKSCQH 212
Cdd:COG0735    84 LNEGdHHHHLICTKCGKVIELDDDE--IEELLEELAEPHG----FEIESHELEIYGLCPDCQK 140
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 87-207 2.07e-23

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 90.33  E-value: 2.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1406955314  87 PQRRAILEIFHDGAGHLTPQQVFATLDDVVPSLSLATVYNTLELLEEIGLLTRVTAHDGQTYFDPTVV-PHHHALCDGCG 165
Cdd:cd07153     1 PQRLAILEVLLESDGHLTAEEIYERLRKKGPSISLATVYRTLELLEEAGLVREIELGDGKARYELNTDeHHHHLICTKCG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1406955314 166 DIFDVFLKPgaLDDLIADAEAFEGanpdFRVTQATVWLRGRC 207
Cdd:cd07153    81 KVIDFEDCP--LEELLEELAAKTG----FKITSHRLELYGIC 116
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 81-192 6.56e-16

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 70.74  E-value: 6.56e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1406955314  81 AGFRLTPQRRAILEIF-HDGAGHLTPQQVFATLDDVVPSLSLATVYNTLELLEEIGLLTRVTAHDGQTYFDPTVVPHH-H 158
Cdd:pfam01475   2 AGLKLTPQRLKILEVLqKSDKEHLSAEEIYKELREEDPNISLATVYRTLNLLEEAGLVKRLEFDGGESRFELNTGHHHdH 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1406955314 159 ALCDGCGDIFDVFLKPgaLDDLIADAEAFEGANP 192
Cdd:pfam01475  82 LICEDCGKVIEFKDDE--IEKRQEEIAKKHGFKL 113
fur PRK09462
ferric uptake regulator; Provisional
 76-212 4.37e-06

ferric uptake regulator; Provisional


Pssm-ID: 236527  Cd Length: 148  Bit Score: 44.72  E-value: 4.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1406955314  76 QRLKDAGFRLTPQRRAILEIFHDGAG-HLTPQQVFATLDDVVPSLSLATVYNTLELLEEIGLLTRVTAHDGQTYFDPTVV 154
Cdd:PRK09462    6 TALKKAGLKVTLPRLKILEVLQEPDNhHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVFELTQQ 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1406955314 155 PHH-HALCDGCGDIFDVflkpgaLDDLIADAEAFEGANPDFRVTQATVWLRGRCK--SCQH 212
Cdd:PRK09462   86 HHHdHLICLDCGKVIEF------SDDSIEARQREIAAKHGIKLTNHSLYLYGHCAegDCRE 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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