NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1403352689|emb|SQF78271|]
View 

phosphoribulokinase/uridine kinase family protein [Streptococcus dysgalactiae subsp. equisimilis]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Udk super family cl30783
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
18-46 1.74e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


The actual alignment was detected with superfamily member COG0572:

Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 35.97  E-value: 1.74e-04
                          10        20
                  ....*....|....*....|....*....
gi 1403352689  18 TVIRICGHGASGKTTLAKRLYQVLPKDST 46
Cdd:COG0572     8 RIIGIAGPSGSGKTTFARRLAEQLGADKV 36
 
Name Accession Description Interval E-value
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
18-46 1.74e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 35.97  E-value: 1.74e-04
                          10        20
                  ....*....|....*....|....*....
gi 1403352689  18 TVIRICGHGASGKTTLAKRLYQVLPKDST 46
Cdd:COG0572     8 RIIGIAGPSGSGKTTFARRLAEQLGADKV 36
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
19-42 2.56e-04

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 35.36  E-value: 2.56e-04
                          10        20
                  ....*....|....*....|....
gi 1403352689  19 VIRICGHGASGKTTLAKRLYQVLP 42
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEELG 24
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
18-45 2.69e-03

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 32.82  E-value: 2.69e-03
                          10        20
                  ....*....|....*....|....*...
gi 1403352689  18 TVIRICGHGASGKTTLAKRLYQVLPKDS 45
Cdd:PRK05480    7 IIIGIAGGSGSGKTTVASTIYEELGDES 34
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
19-47 2.82e-03

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 32.91  E-value: 2.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1403352689  19 VIRICGHGASGKTTLAKRLYQ--------VLPKDSTY 47
Cdd:cd02023     1 IIGIAGGSGSGKTTVAEEIIEqlgnpkvvIISQDSYY 37
 
Name Accession Description Interval E-value
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
18-46 1.74e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 35.97  E-value: 1.74e-04
                          10        20
                  ....*....|....*....|....*....
gi 1403352689  18 TVIRICGHGASGKTTLAKRLYQVLPKDST 46
Cdd:COG0572     8 RIIGIAGPSGSGKTTFARRLAEQLGADKV 36
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
19-42 2.56e-04

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 35.36  E-value: 2.56e-04
                          10        20
                  ....*....|....*....|....
gi 1403352689  19 VIRICGHGASGKTTLAKRLYQVLP 42
Cdd:pfam13671   1 LILLVGLPGSGKSTLARRLLEELG 24
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
22-42 1.43e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 33.35  E-value: 1.43e-03
                          10        20
                  ....*....|....*....|.
gi 1403352689  22 ICGHGASGKTTLAKRLYQVLP 42
Cdd:COG0645     4 VCGLPGSGKSTLARALAERLG 24
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
18-45 2.69e-03

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 32.82  E-value: 2.69e-03
                          10        20
                  ....*....|....*....|....*...
gi 1403352689  18 TVIRICGHGASGKTTLAKRLYQVLPKDS 45
Cdd:PRK05480    7 IIIGIAGGSGSGKTTVASTIYEELGDES 34
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
19-47 2.82e-03

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 32.91  E-value: 2.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1403352689  19 VIRICGHGASGKTTLAKRLYQ--------VLPKDSTY 47
Cdd:cd02023     1 IIGIAGGSGSGKTTVAEEIIEqlgnpkvvIISQDSYY 37
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
19-42 4.63e-03

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 32.30  E-value: 4.63e-03
                          10        20
                  ....*....|....*....|....
gi 1403352689  19 VIRICGHGASGKTTLAKRLYQVLP 42
Cdd:cd02024     1 IVGISGVTNSGKTTLAKLLQRILP 24
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
19-37 8.57e-03

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 31.51  E-value: 8.57e-03
                          10
                  ....*....|....*....
gi 1403352689  19 VIRICGHGASGKTTLAKRL 37
Cdd:PRK14493    3 VLSIVGYKATGKTTLVERL 21
MobB pfam03205
Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.
19-41 9.66e-03

Molybdopterin guanine dinucleotide synthesis protein B; This protein contains a P-loop.


Pssm-ID: 427196 [Multi-domain]  Cd Length: 133  Bit Score: 30.98  E-value: 9.66e-03
                          10        20
                  ....*....|....*....|...
gi 1403352689  19 VIRICGHGASGKTTLAKRLYQVL 41
Cdd:pfam03205   1 ILGIVGWSGSGKTTLLEKLIPEL 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH