acetaldehyde dehydrogenase (acetylating); Members of this protein family are acetaldehyde ...
4-244
2.07e-158
acetaldehyde dehydrogenase (acetylating); Members of this protein family are acetaldehyde dehydrogenase (acetylating), EC 1.2.1.10. This enzyme oxidizes acetaldehyde, using NAD(+), and attaches coenzyme A (CoA), yielding acetyl-CoA. It occurs as a late step in the meta-cleavage pathways of a variety of compounds, including catechol, biphenyl, toluene, salicylate, etc.
Pssm-ID: 132259 [Multi-domain] Cd Length: 285 Bit Score: 440.60 E-value: 2.07e-158
Prokaryotic acetaldehyde dehydrogenase, dimerization; Members of this family are found in ...
131-244
4.07e-77
Prokaryotic acetaldehyde dehydrogenase, dimerization; Members of this family are found in prokaryotic acetaldehyde dehydrogenase (acylating), and adopt a structure consisting of an alpha-beta-alpha-beta(3) core. They mediate dimerization of the protein.
Pssm-ID: 430505 Cd Length: 138 Bit Score: 228.95 E-value: 4.07e-77
C-terminal catalytic domain of acetaldehyde dehydrogenase (ALDH) and similar proteins; ...
131-244
1.39e-67
C-terminal catalytic domain of acetaldehyde dehydrogenase (ALDH) and similar proteins; Acetaldehyde dehydrogenase (ALDH; EC 1.2.1.10), also called acetaldehyde dehydrogenase (acetylating), acylating acetaldehyde dehydrogenase, or aldehyde dehydrogenase (acylating), catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. It can also act on propanal and butanal to form propanoyl-CoA and butanoyl-CoA, respectively. ALDH is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds such as phenols, cresols and catechols. NADP(+) can replace NAD(+) but the rate of reaction is much slower. ALDH contains two domains, an N-terminal Rossmann fold NAD+-binding domain and a C-terminal dimerization domain, which mediates dimerisation of the protein. The C-terminal dimerization domain is homologs to C-terminal glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-like catalytic domain. ALDHs are members of the GAPDH superfamily of proteins.
Pssm-ID: 467682 Cd Length: 135 Bit Score: 204.78 E-value: 1.39e-67
acetaldehyde dehydrogenase (acetylating); Members of this protein family are acetaldehyde ...
4-244
2.07e-158
acetaldehyde dehydrogenase (acetylating); Members of this protein family are acetaldehyde dehydrogenase (acetylating), EC 1.2.1.10. This enzyme oxidizes acetaldehyde, using NAD(+), and attaches coenzyme A (CoA), yielding acetyl-CoA. It occurs as a late step in the meta-cleavage pathways of a variety of compounds, including catechol, biphenyl, toluene, salicylate, etc.
Pssm-ID: 132259 [Multi-domain] Cd Length: 285 Bit Score: 440.60 E-value: 2.07e-158
Prokaryotic acetaldehyde dehydrogenase, dimerization; Members of this family are found in ...
131-244
4.07e-77
Prokaryotic acetaldehyde dehydrogenase, dimerization; Members of this family are found in prokaryotic acetaldehyde dehydrogenase (acylating), and adopt a structure consisting of an alpha-beta-alpha-beta(3) core. They mediate dimerization of the protein.
Pssm-ID: 430505 Cd Length: 138 Bit Score: 228.95 E-value: 4.07e-77
C-terminal catalytic domain of acetaldehyde dehydrogenase (ALDH) and similar proteins; ...
131-244
1.39e-67
C-terminal catalytic domain of acetaldehyde dehydrogenase (ALDH) and similar proteins; Acetaldehyde dehydrogenase (ALDH; EC 1.2.1.10), also called acetaldehyde dehydrogenase (acetylating), acylating acetaldehyde dehydrogenase, or aldehyde dehydrogenase (acylating), catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. It can also act on propanal and butanal to form propanoyl-CoA and butanoyl-CoA, respectively. ALDH is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds such as phenols, cresols and catechols. NADP(+) can replace NAD(+) but the rate of reaction is much slower. ALDH contains two domains, an N-terminal Rossmann fold NAD+-binding domain and a C-terminal dimerization domain, which mediates dimerisation of the protein. The C-terminal dimerization domain is homologs to C-terminal glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-like catalytic domain. ALDHs are members of the GAPDH superfamily of proteins.
Pssm-ID: 467682 Cd Length: 135 Bit Score: 204.78 E-value: 1.39e-67
C-terminal catalytic domain found in glyceraldehyde-3-phosphate dehydrogenase (GAPDH) ...
131-241
1.04e-13
C-terminal catalytic domain found in glyceraldehyde-3-phosphate dehydrogenase (GAPDH) superfamily of proteins; GAPDH-like C-terminal catalytic domains are typically associated with a classic N-terminal Rossmann fold NAD(P)-binding domain. This superfamily includes the C-terminal domains of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), N-acetyl-gamma-glutamyl-phosphate reductase (AGPR), aspartate beta-semialdehyde dehydrogenase (ASADH), acetaldehyde dehydrogenase (ALDH) and USG-1 homolog proteins.
Pssm-ID: 467672 [Multi-domain] Cd Length: 166 Bit Score: 66.77 E-value: 1.04e-13
Semialdehyde dehydrogenase, NAD binding domain; This Pfam entry contains the following members: ...
6-118
4.08e-13
Semialdehyde dehydrogenase, NAD binding domain; This Pfam entry contains the following members: N-acetyl-glutamine semialdehyde dehydrogenase (AgrC) Aspartate-semialdehyde dehydrogenase
Pssm-ID: 426059 [Multi-domain] Cd Length: 121 Bit Score: 64.08 E-value: 4.08e-13
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
Click on the triangle to view details about the feature, including a multiple sequence alignment
of your query sequence and the protein sequences used to curate the domain model,
where hash marks (#) above the aligned sequences show the location of the conserved feature residues.
The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
Click on the triangle for interactive 3D structure viewing options.
Functional characterization of the conserved domain architecture found on the query.
Click here to see more details.
This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
(labeled illustration) or all hits
(labeled illustration).
Domains are color coded according to superfamilies
to which they have been assigned. Hits with scores that pass a domain-specific threshold
(specific hits) are drawn in bright colors.
Others (non-specific hits) and
superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features),
they are mapped to the query sequence and indicated through sets of triangles
with the same color and shade of the domain or superfamily that provides the annotation. Mouse over the colored bars or triangles to see descriptions of the domains and features.
click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
mapped to the query sequence.
Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
(CDART).
Modify your query to search against a different database and/or use advanced search options
