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Conserved domains on  [gi|1401585373|ref|NP_001351207|]
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interleukin-6 receptor subunit beta isoform 7 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10637183)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  8981327|9837732|19576999

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 218-298 6.99e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 6.99e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585373  218 PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDE 297
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 1401585373  298 G 298
Cdd:smart00060  81 G 81
 
Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 218-298 6.99e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 6.99e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585373  218 PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDE 297
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 1401585373  298 G 298
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 218-309 4.48e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 4.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585373 218 PSKGPTVRTKKVGKNEAVLEWDqlPVDVQNGFIRNYTIFYRTIIGNE--TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYT 295
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 1401585373 296 DEG-GKDGPEFTFTT 309
Cdd:cd00063    79 GGGeSPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
229-298 2.22e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 2.22e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1401585373 229 VGKNEAVLEWDqlPVDVQNGFIRNYTIFYRTIIGNETA--VNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 298
Cdd:pfam00041  11 VTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEPWneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
183-298 2.00e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.14  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585373 183 GNLAESKCYLITVTPVYADGPGSP-ESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDqlpvDVQNGFIRNYTIfYRTII 261
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPsNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWD----PVTESDATGYRV-YRSNS 271

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1401585373 262 GNETAVNV-DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 298
Cdd:COG3401   272 GDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
 
Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 218-298 6.99e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 6.99e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585373  218 PSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDE 297
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 1401585373  298 G 298
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 218-309 4.48e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 4.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585373 218 PSKGPTVRTKKVGKNEAVLEWDqlPVDVQNGFIRNYTIFYRTIIGNE--TAVNVDSSHTEYTLSSLTSDTLYMVRMAAYT 295
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDwkEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|....*
gi 1401585373 296 DEG-GKDGPEFTFTT 309
Cdd:cd00063    79 GGGeSPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
229-298 2.22e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 2.22e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1401585373 229 VGKNEAVLEWDqlPVDVQNGFIRNYTIFYRTIIGNETA--VNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEG 298
Cdd:pfam00041  11 VTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEPWneITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
183-298 2.00e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 41.14  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585373 183 GNLAESKCYLITVTPVYADGPGSP-ESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDqlpvDVQNGFIRNYTIfYRTII 261
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPsNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWD----PVTESDATGYRV-YRSNS 271

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1401585373 262 GNETAVNV-DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 298
Cdd:COG3401   272 GDGPFTKVaTVTTTSYTDTGLTNGTTYYYRVTAVDAAG 309
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
179-298 9.24e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.22  E-value: 9.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1401585373 179 TYLRGNLAESKCYLITVTPVYADGPGSPES--IKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDqlpvDVQNGFIRNYTIf 256
Cdd:COG3401   286 SYTDTGLTNGTTYYYRVTAVDAAGNESAPSnvVSVTTDLTPPAAPSGLTATAVGSSSITLSWT----ASSDADVTGYNV- 360

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1401585373 257 YRTIIGNETAVNVDSSH--TEYTLSSLTSDTLYMVRMAAYTDEG 298
Cdd:COG3401   361 YRSTSGGGTYTKIAETVttTSYTDTGLTPGTTYYYKVTAVDAAG 404
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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