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Conserved domains on  [gi|1396648825|gb|PXM48357|]
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DNA-binding transcriptional repressor [Klebsiella variicola]

Protein Classification

glucitol operon DNA-binding transcriptional repressor SrlR( domain architecture ID 11484720)

glucitol operon DNA-binding transcriptional repressor SrlR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
srlR PRK10434
DNA-binding transcriptional repressor;
1-256 0e+00

DNA-binding transcriptional repressor;


:

Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 531.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   1 MKPRQRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVLNKDEADPPIDHKTLINTHKKAQ 80
Cdd:PRK10434    1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  81 IAEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNEQTILMPGGTFRKKSASFHGQLAENA 160
Cdd:PRK10434   81 IAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 161 FEQFSFDKLFMGTDGIDLVAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAEIDPEFQR 240
Cdd:PRK10434  161 FEHFTFDKLFIGTDGIDLNAGVTTFNEVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQ 240

                         250
                  ....*....|....*.
gi 1396648825 241 ALEAKGIEVIITGEHH 256
Cdd:PRK10434  241 ALEEKGIEVIITGESN 256
 
Name Accession Description Interval E-value
srlR PRK10434
DNA-binding transcriptional repressor;
1-256 0e+00

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 531.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   1 MKPRQRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVLNKDEADPPIDHKTLINTHKKAQ 80
Cdd:PRK10434    1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  81 IAEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNEQTILMPGGTFRKKSASFHGQLAENA 160
Cdd:PRK10434   81 IAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 161 FEQFSFDKLFMGTDGIDLVAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAEIDPEFQR 240
Cdd:PRK10434  161 FEHFTFDKLFIGTDGIDLNAGVTTFNEVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQ 240

                         250
                  ....*....|....*.
gi 1396648825 241 ALEAKGIEVIITGEHH 256
Cdd:PRK10434  241 ALEEKGIEVIITGESN 256
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-251 2.41e-108

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 313.22  E-value: 2.41e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   1 MKPRQRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVLN-KDEADPPIDHKTLINTHKKA 79
Cdd:COG1349     1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVsSAAAEPPFAERETLNAEEKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  80 QIAEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNeQTILMPGGTFRKKSASFHGQLAEN 159
Cdd:COG1349    81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPN-IEVILLGGELRPSSGSLVGPLAEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 160 AFEQFSFDKLFMGTDGIDLVAGVTTFN-EVYTVSKAMCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAEIDPEF 238
Cdd:COG1349   160 ALRRFRADKAFLGASGIDAEGGLTTFDeEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPEL 239

                         250
                  ....*....|...
gi 1396648825 239 QRALEAKGIEVII 251
Cdd:COG1349   240 LEALEEAGVEVIV 252
AgaR NF040755
transcriptional repressor AgaR;
5-251 2.90e-77

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 234.09  E-value: 2.90e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   5 QRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVLNK---DEADPPIDHKTLINTHKKAQI 81
Cdd:NF040755    6 ERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALINDgfiPGAEPSVEDKSRLNTAVKRLI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  82 AEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNEQtILMPGGTFRKKSASFHGQLAENAF 161
Cdd:NF040755   86 AAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVE-VLMTGGHLRRQSLSFYGDQAEQSL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 162 EQFSFDKLFMGTDGIDLVAGVTTFNE-VYTVSKAMCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAEIDPEFQR 240
Cdd:NF040755  165 QNYHFDKLFLGVDGFDLERGITTHNEdEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEEYLQ 244

                         250
                  ....*....|.
gi 1396648825 241 ALEAKGIEVII 251
Cdd:NF040755  245 GLRKLGVEVIL 255
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 73-232 4.24e-65

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 199.66  E-value: 4.24e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  73 INTHKKAQIAEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNeQTILMPGGTFRKKSASF 152
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPD-IEVILLGGEVRPKTGAF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 153 HGQLAENAFEQFSFDKLFMGTDGIDLVAGVTTFNE-VYTVSKAMCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITD 231
Cdd:pfam00455  80 VGPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEeEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159


                  .
gi 1396648825 232 A 232
Cdd:pfam00455 160 K 160
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-58 4.88e-17

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 72.64  E-value: 4.88e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1396648825    6 RQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVL 58
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAVS 53
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 9-51 5.55e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 34.74  E-value: 5.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1396648825   9 AILEHLqSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIR 51
Cdd:NF033788   15 RILELL-AEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTS 56
 
Name Accession Description Interval E-value
srlR PRK10434
DNA-binding transcriptional repressor;
1-256 0e+00

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 531.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   1 MKPRQRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVLNKDEADPPIDHKTLINTHKKAQ 80
Cdd:PRK10434    1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  81 IAEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNEQTILMPGGTFRKKSASFHGQLAENA 160
Cdd:PRK10434   81 IAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSELDNEQTILMPGGTFRKKSASFHGQLAENA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 161 FEQFSFDKLFMGTDGIDLVAGVTTFNEVYTVSKAMCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAEIDPEFQR 240
Cdd:PRK10434  161 FEHFTFDKLFIGTDGIDLNAGVTTFNEVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGIDPAFRQ 240

                         250
                  ....*....|....*.
gi 1396648825 241 ALEAKGIEVIITGEHH 256
Cdd:PRK10434  241 ALEEKGIEVIITGESN 256
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-251 2.41e-108

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 313.22  E-value: 2.41e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   1 MKPRQRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVLN-KDEADPPIDHKTLINTHKKA 79
Cdd:COG1349     1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVsSAAAEPPFAERETLNAEEKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  80 QIAEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNeQTILMPGGTFRKKSASFHGQLAEN 159
Cdd:COG1349    81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPN-IEVILLGGELRPSSGSLVGPLAEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 160 AFEQFSFDKLFMGTDGIDLVAGVTTFN-EVYTVSKAMCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAEIDPEF 238
Cdd:COG1349   160 ALRRFRADKAFLGASGIDAEGGLTTFDeEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGPPPEL 239

                         250
                  ....*....|...
gi 1396648825 239 QRALEAKGIEVII 251
Cdd:COG1349   240 LEALEEAGVEVIV 252
AgaR NF040755
transcriptional repressor AgaR;
5-251 2.90e-77

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 234.09  E-value: 2.90e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   5 QRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVLNK---DEADPPIDHKTLINTHKKAQI 81
Cdd:NF040755    6 ERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALINDgfiPGAEPSVEDKSRLNTAVKRLI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  82 AEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNEQtILMPGGTFRKKSASFHGQLAENAF 161
Cdd:NF040755   86 AAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVE-VLMTGGHLRRQSLSFYGDQAEQSL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 162 EQFSFDKLFMGTDGIDLVAGVTTFNE-VYTVSKAMCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAEIDPEFQR 240
Cdd:NF040755  165 QNYHFDKLFLGVDGFDLERGITTHNEdEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGIPEEYLQ 244

                         250
                  ....*....|.
gi 1396648825 241 ALEAKGIEVII 251
Cdd:NF040755  245 GLRKLGVEVIL 255
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 73-232 4.24e-65

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 199.66  E-value: 4.24e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  73 INTHKKAQIAEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNeQTILMPGGTFRKKSASF 152
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPD-IEVILLGGEVRPKTGAF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 153 HGQLAENAFEQFSFDKLFMGTDGIDLVAGVTTFNE-VYTVSKAMCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITD 231
Cdd:pfam00455  80 VGPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEeEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159


                  .
gi 1396648825 232 A 232
Cdd:pfam00455 160 K 160
PRK09802 PRK09802
DeoR family transcriptional regulator;
4-254 2.65e-62

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 196.61  E-value: 2.65e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   4 RQRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVL---NKDEADPPIDHKTLINTHKKAQ 80
Cdd:PRK09802   16 SERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALIcdsTTPSVEPSVEDKSALNTAMKRS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  81 IAEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNeQTILMPGGTFRKKSASFHGQLAENA 160
Cdd:PRK09802   96 VAKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEG-VELLMTGGHLRRQSQSFYGDQAEQS 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 161 FEQFSFDKLFMGTDGIDLVAGVTTFNEVYT-VSKAMCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAEIDPEFQ 239
Cdd:PRK09802  175 LQNYHFDMLFLGVDAIDLERGVSTHNEDEArLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSL 254

                         250
                  ....*....|....*
gi 1396648825 240 RALEAKGIEVIITGE 254
Cdd:PRK09802  255 EGLRKAGVEVILVGE 269
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
1-243 7.24e-30

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 112.26  E-value: 7.24e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   1 MKPRQRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVLNKDEADPPIDHKTLINTHKKAQ 80
Cdd:PRK10906    1 MKQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALPSSSVNTPWHDRKATQTEEKER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  81 IAEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNEQTILmPGGTFRKKSASFHGQLAENA 160
Cdd:PRK10906   81 IARKVASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDFRIIL-AGGELRSRDGGIIGEATLDF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 161 FEQFSFDKLFMGTDGIDLVAGVTTFN--EVYTvSKAMCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAEIDPEF 238
Cdd:PRK10906  160 ISQFRLDFGILGISGIDSDGSLLEFDyhEVRT-KRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQLPPASV 238


                  ....*
gi 1396648825 239 QRALE 243
Cdd:PRK10906  239 MQVIE 243
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
1-251 1.01e-27

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 106.63  E-value: 1.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   1 MKPRQRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTV--IRTYGGVVLNKDEADPPIDHKTLINTHKK 78
Cdd:PRK13509    1 MTEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLkkVRNGAEAITQQRPRWTPMNIHQAQNHDEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  79 AQIAEAAVRYIHDGDSIILDAGSTVLqmvpLLSRF---NNITVMTNSLHIVNALSEFDNEQTILMpGGTFRKKSASFhgq 155
Cdd:PRK13509   81 VRIAKAASQLCNPGESVVINCGSTAF----LLGRElcgKPVQIITNYLPLANYLIDQEHDSVIIM-GGQYNKSQSIT--- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 156 LAENAFEQFSFDKLFMGTDGIDLVA-GVTTFNEVYTVSKA-MCNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAE 233
Cdd:PRK13509  153 LSPQGSENSLYAGHWMFTSGKGLTAdGLYKTDMLTAMAEQkMLSVVGKLVVLVDSSKIGERAGMLFSRADQIDMLITGKN 232

                         250
                  ....*....|....*...
gi 1396648825 234 IDPEFQRALEAKGIEVII 251
Cdd:PRK13509  233 ADPEVLQQLEAQGVSILL 250
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
6-60 2.46e-18

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 76.14  E-value: 2.46e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1396648825   6 RQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVLNK 60
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNS 55
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 1-250 1.25e-17

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 79.36  E-value: 1.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   1 MKPR--QRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVilENAGTVIRTYGGVVLNKDEADPPI--DHKTLInTH 76
Cdd:PRK10681    1 METRrdERIGQLLQALKRSDKLHLKDAAALLGVSEMTIRRDLN--AHSAPVVLLGGYIVLEPRSASHYLlsDQKSRL-VE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  77 KKAQIAEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSEFDNEQTILMpGGTFRKKSASFHGQL 156
Cdd:PRK10681   78 EKRRAAQLAATLVEPNQTLFFDCGTTTPWIIEAIDNELPFTAVCYSLNTFLALQEKPHCRAILC-GGEFHASNAIFKPLD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825 157 AENAFEQFSFDKLFMGTDGIDLVAGVTTFN--EVYTVSKAMcNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAEI 234
Cdd:PRK10681  157 FQQTLDNICPDIAFYSAAGVHVSKGATCFNleELPVKHWAM-AMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSDRCP 235

                         250
                  ....*....|....*.
gi 1396648825 235 DPEFQRALEAKGIEVI 250
Cdd:PRK10681  236 DDEFVKYAQAQRIKLM 251
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-58 4.88e-17

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 72.64  E-value: 4.88e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1396648825    6 RQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVL 58
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAVS 53
PRK10411 PRK10411
L-fucose operon activator;
6-233 8.23e-17

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 77.15  E-value: 8.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825   6 RQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGGVVL----NKDEADPpidHKTLINTH--KKA 79
Cdd:PRK10411    5 RQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYihrqNQDSGDP---FHIRLKSHyaHKA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396648825  80 QIAEAAVRYIHDGDSIILDAGSTVLQMVPLLSRFnNITVMTNSLHIVNALSEFDNEQTIlMPGGTFRKKSASFHGQLAEN 159
Cdd:PRK10411   82 DIAREALAWIEEGMVIALDASSTCWYLARQLPDI-NIQVFTNSHPICQELGKRERIQLI-SSGGTLERKYGCYVNPSLIS 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1396648825 160 AFEQFSFDKLFMGTDGIDLVAGVTTFNEVYTVSKAM-CNAAREVILMADSSKFGRKSPNIVCGLERVDKLITDAE 233
Cdd:PRK10411  160 QLKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMlLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDER 234
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 1-67 3.28e-08

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 53.16  E-value: 3.28e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1396648825   1 MKPRQRQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRT----YGGVVLNKDEADPPI 67
Cdd:COG2378     1 MSRLERLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELGVPIEAergrGGGYRLRDGYRLPPL 71
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-53 2.90e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 46.84  E-value: 2.90e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1396648825   6 RQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTY 53
Cdd:COG2345    14 TRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 9-50 1.98e-04

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 38.18  E-value: 1.98e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1396648825   9 AILEHL-QSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVI 50
Cdd:pfam08279   2 QILQLLlEARGPISGQELAEKLGVSRRTIRRDIKILEELGVPI 44
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
10-55 1.90e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 36.03  E-value: 1.90e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1396648825   10 ILEHLqSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIRTYGG 55
Cdd:smart00418   2 ILKLL-AEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREG 46
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 8-52 4.96e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 34.44  E-value: 4.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1396648825   8 AAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAG--TVIRT 52
Cdd:pfam12840  13 LRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGlvEVVRE 59
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 9-51 5.55e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 34.74  E-value: 5.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1396648825   9 AILEHLqSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTVIR 51
Cdd:NF033788   15 RILELL-AEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTS 56
HTH_PafC pfam19187
PafC helix-turn-helix domain; This entry is an N-terminal HTH domain found in the PafC protein. ...
 6-47 7.58e-03

PafC helix-turn-helix domain; This entry is an N-terminal HTH domain found in the PafC protein. Transcriptional activator PafBC is responsible for upregulating the majority of genes induced by DNA damage.


Pssm-ID: 465990 [Multi-domain]  Cd Length: 115  Bit Score: 35.23  E-value: 7.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1396648825   6 RQAAILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAG 47
Cdd:pfam19187   5 RLLDLVPYLRQHPGVSVAEAAARFGVTPAQLRADLDVLFVCG 46
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
10-49 8.15e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 35.39  E-value: 8.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1396648825  10 ILEHLqSQGKCSVEELAQHFDTTGTTIRKDLVILENAGTV 49
Cdd:COG1777    22 ILALL-SEEPAYVSELARELGVSRQAVYKHLRKLEEAGLV 60
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
9-57 8.99e-03

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 35.52  E-value: 8.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1396648825   9 AILEHLQSQGKCSVEELAQHFDTTGTTIRKDLVILENAGtVIRTYGGVV 57
Cdd:COG1522     9 RILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAG-VIRGYGAVV 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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