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Conserved domains on  [gi|139424537|ref|YP_001129503|]
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BILF2 [Human herpesvirus 4 type 2]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set super family cl46292
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-124 3.28e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.53  E-value: 3.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139424537   28 VTAHAGARVNLTCSVPSNES--VSRIELGRGYTPGDGQLPLAVATSNNGTHITNGGYnySLTLewvNDSNTSVSLIIPNV 105
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSeaSTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRF--SGRG---DPSNGDGSLTIQNL 80

                          90
                  ....*....|....*....
gi 139424537  106 TLAHAGYYTCNVTLRNCSV 124
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGV 99
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-124 3.28e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.53  E-value: 3.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139424537   28 VTAHAGARVNLTCSVPSNES--VSRIELGRGYTPGDGQLPLAVATSNNGTHITNGGYnySLTLewvNDSNTSVSLIIPNV 105
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSeaSTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRF--SGRG---DPSNGDGSLTIQNL 80

                          90
                  ....*....|....*....
gi 139424537  106 TLAHAGYYTCNVTLRNCSV 124
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGV 99
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-129 1.87e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 1.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139424537    26 ENVTAHAGARVNLTCSVPSNESVsRIELgrgytpgdgqlplavaTSNNGTHITNGGyNYSLTlewvnDSNTSVSLIIPNV 105
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPP-EVTW----------------YKQGGKLLAESG-RFSVS-----RSGSTSTLTISNV 58

                           90       100
                   ....*....|....*....|....
gi 139424537   106 TLAHAGYYTCNVTLRNCSVASGVH 129
Cdd:smart00410  59 TPEDSGTYTCAATNSSGSASSGTT 82
IgI_6_Dscam cd20959
Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 25-115 2.81e-04

Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the sixth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409551  Cd Length: 94  Bit Score: 39.01  E-value: 2.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139424537  25 FENVTAHAGARVNLTCSVPsnesvsrielgrgytpgDGQLPLAVA-TSNNGTHITNGGYNYSLTlewvnDSNTSVsLIIP 103
Cdd:cd20959    9 FGEGAAQVGMRAQLHCGVP-----------------GGDLPLNIRwTLDGQPISDDLGITVSRL-----GRRSSI-LSID 65

                         90
                 ....*....|..
gi 139424537 104 NVTLAHAGYYTC 115
Cdd:cd20959   66 SLEASHAGNYTC 77
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 28-124 3.28e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.53  E-value: 3.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139424537   28 VTAHAGARVNLTCSVPSNES--VSRIELGRGYTPGDGQLPLAVATSNNGTHITNGGYnySLTLewvNDSNTSVSLIIPNV 105
Cdd:pfam07686   6 VTVALGGSVTLPCTYSSSMSeaSTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRF--SGRG---DPSNGDGSLTIQNL 80

                          90
                  ....*....|....*....
gi 139424537  106 TLAHAGYYTCNVTLRNCSV 124
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGV 99
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 26-129 1.87e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 42.11  E-value: 1.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139424537    26 ENVTAHAGARVNLTCSVPSNESVsRIELgrgytpgdgqlplavaTSNNGTHITNGGyNYSLTlewvnDSNTSVSLIIPNV 105
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPP-EVTW----------------YKQGGKLLAESG-RFSVS-----RSGSTSTLTISNV 58

                           90       100
                   ....*....|....*....|....
gi 139424537   106 TLAHAGYYTCNVTLRNCSVASGVH 129
Cdd:smart00410  59 TPEDSGTYTCAATNSSGSASSGTT 82
IgI_6_Dscam cd20959
Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
 25-115 2.81e-04

Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the sixth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409551  Cd Length: 94  Bit Score: 39.01  E-value: 2.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139424537  25 FENVTAHAGARVNLTCSVPsnesvsrielgrgytpgDGQLPLAVA-TSNNGTHITNGGYNYSLTlewvnDSNTSVsLIIP 103
Cdd:cd20959    9 FGEGAAQVGMRAQLHCGVP-----------------GGDLPLNIRwTLDGQPISDDLGITVSRL-----GRRSSI-LSID 65

                         90
                 ....*....|..
gi 139424537 104 NVTLAHAGYYTC 115
Cdd:cd20959   66 SLEASHAGNYTC 77
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 23-118 4.53e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.93  E-value: 4.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139424537   23 VKFENVTAHAGARVNLTCSvpsnesvsrielgrgytpgdgqlplavATSNNGTHIT---NGGYNYSLTLEWVNDSNTSVS 99
Cdd:pfam13927   6 VSPSSVTVREGETVTLTCE---------------------------ATGSPPPTITwykNGEPISSGSTRSRSLSGSNST 58

                          90
                  ....*....|....*....
gi 139424537  100 LIIPNVTLAHAGYYTCNVT 118
Cdd:pfam13927  59 LTISNVTRSDAGTYTCVAS 77
IgV_1_Nectin-3_like cd05887
First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor ...
 28-117 4.20e-03

First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor related protein 3), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 (PVRL3) or cluster of differentiation (CD) 113). Nectin-3 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example, during spermatid development, the nectin-3,-2 trans-interaction is required for the formation of Sertoli cell-spermatid junctions in testis, and during morphogenesis of the ciliary body, the nectin-3,-1 trans-interaction is important for apex-apex adhesion between the pigment and non-pigment layers of the ciliary epithelia. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls); nectin-3 for example, trans-interacts with Necl-5, regulating cell movement and proliferation. Other proteins with which nectin-3 interacts include the actin filament-binding protein, afadin, integrin alpha-beta3, Par-3, and PDGF receptor; its interaction with PDGF receptor regulates the latter's signaling for anti-apoptosis.


Pssm-ID: 409470  Cd Length: 110  Bit Score: 36.07  E-value: 4.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139424537  28 VTAHAGARVNLTCSVPSNESVSRIELGRGYtpGDGQLPLAVATSNNGTHITNggyNYSLTLEWVNDSNTSVSLIIPNVTL 107
Cdd:cd05887    9 VTAVWGKNVSLKCLIEVNETITQISWEKIH--GKSSQTVAVHHPQYGISIQG---EYQGRVSFKNYSLNDATITLHNVGF 83

                         90
                 ....*....|
gi 139424537 108 AHAGYYTCNV 117
Cdd:cd05887   84 SDSGKYICKA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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