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Conserved domains on  [gi|13937865|gb|AAH07038|]
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Lumican [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-321 3.95e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 3.95e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  71 LYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVgplpKSLEDLQLTHNKIT 150
Cdd:COG4886  51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLT 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 151 KLG-SFEGLVNLTFIHLQHNRLKEdaVSAAFKGLKSLEYLDLSFNQIARLPSGLP--VSLLTLYLDNNKISNIPDEyFKR 227
Cdd:COG4886 127 DLPeELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGN 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 228 FNALQYLRLSHNELADsgIPGNSFNVSSLVELDLSYNKLKNIPTVNE--NLENYYLEVNQLEkfDIKSFCKIlgplsySK 305
Cdd:COG4886 204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLT--DLPPLANL------TN 273

                       250
                ....*....|....*.
gi 13937865 306 IKHLRLDGNRISETSL 321
Cdd:COG4886 274 LKTLDLSNNQLTDLKL 289
LRRNT smart00013
Leucine rich repeat N-terminal domain;
37-71 8.24e-07

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.00  E-value: 8.24e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 13937865     37 CAPECNCPesyPSAMYCDELKLKSVPMVPPGIKYL 71
Cdd:smart00013   2 CPAPCNCS---GTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-321 3.95e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 3.95e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  71 LYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVgplpKSLEDLQLTHNKIT 150
Cdd:COG4886  51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLT 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 151 KLG-SFEGLVNLTFIHLQHNRLKEdaVSAAFKGLKSLEYLDLSFNQIARLPSGLP--VSLLTLYLDNNKISNIPDEyFKR 227
Cdd:COG4886 127 DLPeELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGN 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 228 FNALQYLRLSHNELADsgIPGNSFNVSSLVELDLSYNKLKNIPTVNE--NLENYYLEVNQLEkfDIKSFCKIlgplsySK 305
Cdd:COG4886 204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLT--DLPPLANL------TN 273

                       250
                ....*....|....*.
gi 13937865 306 IKHLRLDGNRISETSL 321
Cdd:COG4886 274 LKTLDLSNNQLTDLKL 289
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-242 3.13e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 3.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865   42 NCPESYPSAMYCDELKLKSVPM-VPPGIKYLYLRNNQIDHIDEKAFENVTDLQwlildhnllENSKIKGRVFSKLKQ-LK 119
Cdd:PRK15370 174 DCLKNNKTELRLKILGLTTIPAcIPEQITTLILDNNELKSLPENLQGNIKTLY---------ANSNQLTSIPATLPDtIQ 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  120 KLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSF--EGLVNL------------------TFIHLQHNRLK------- 172
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENlpEELRYLsvydnsirtlpahlpsgiTHLNVQSNSLTalpetlp 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  173 ---------EDAVSAAFKGLK-SLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKrfnALQYLRLSHNELA 242
Cdd:PRK15370 325 pglktleagENALTSLPASLPpELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPA---ALQIMQASRNNLV 401
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-200 5.76e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 5.76e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  66 PGIKYLYLRNNQIDHIDekAFENVTDLQWLILDHNLLEnsKIKGrvFSKLKQLKKLHINHN------------NLTE--- 130
Cdd:cd21340  24 KNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE--KIEN--LENLVNLKKLYLGGNrisvveglenltNLEElhi 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 131 ----------------SVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKE-DAVSAAFKGLKSLEYLDLSF 193
Cdd:cd21340  98 enqrlppgekltfdprSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDlEELLDLLSSWPSLRELDLTG 177


                ....*..
gi 13937865 194 NQIARLP 200
Cdd:cd21340 178 NPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
66-128 1.27e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.27e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13937865    66 PGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLenSKIKGRVFSKLKQLKKLHINHNNL 128
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
37-71 8.24e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.00  E-value: 8.24e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 13937865     37 CAPECNCPesyPSAMYCDELKLKSVPMVPPGIKYL 71
Cdd:smart00013   2 CPAPCNCS---GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 37-66 1.07e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.54  E-value: 1.07e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 13937865    37 CAPECNCPesyPSAMYCDELKLKSVPMVPP 66
Cdd:pfam01462   2 CPVPCHCS---ATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-321 3.95e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.93  E-value: 3.95e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  71 LYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVgplpKSLEDLQLTHNKIT 150
Cdd:COG4886  51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLT 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 151 KLG-SFEGLVNLTFIHLQHNRLKEdaVSAAFKGLKSLEYLDLSFNQIARLPSGLP--VSLLTLYLDNNKISNIPDEyFKR 227
Cdd:COG4886 127 DLPeELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGN 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 228 FNALQYLRLSHNELADsgIPGNSFNVSSLVELDLSYNKLKNIPTVNE--NLENYYLEVNQLEkfDIKSFCKIlgplsySK 305
Cdd:COG4886 204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLT--DLPPLANL------TN 273

                       250
                ....*....|....*.
gi 13937865 306 IKHLRLDGNRISETSL 321
Cdd:COG4886 274 LKTLDLSNNQLTDLKL 289
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-314 7.84e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 7.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  68 IKYLYLRNNQIDHIDEkAFENVTDLQWLILDHNLLENSkikGRVFSKLKQLKKLHINHNNLT---ESVGPLPKsLEDLQL 144
Cdd:COG4886 115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL---PEPLGNLTNLKSLDLSNNQLTdlpEELGNLTN-LKELDL 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 145 THNKITKLG-SFEGLVNLTFIHLQHNRLKEdaVSAAFKGLKSLEYLDLSFNQIARLP--SGLPvSLLTLYLDNNKISNIP 221
Cdd:COG4886 190 SNNQITDLPePLGNLTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLSNNQLTDLP 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 222 DEyfKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQLEKFDIKSFCKILGPL 301
Cdd:COG4886 267 PL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSL 344

                       250
                ....*....|...
gi 13937865 302 SYSKIKHLRLDGN 314
Cdd:COG4886 345 SLLALLTLLLLLN 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-291 1.82e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 1.82e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  66 PGIKYLYLRNNQIDHIDEkAFENVTDLQWLILDHNLLENSkikGRVFSKLKQLKKLHINHNNLT---ESVGPLpKSLEDL 142
Cdd:COG4886 159 TNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTdlpEPLANL-TNLETL 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 143 QLTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVSAafkGLKSLEYLDLSFNQIARLP-SGLPVSLLTLYLDNNKISNIP 221
Cdd:COG4886 234 DLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLA---NLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNL 310

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 222 DEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQLEKFDI 291
Cdd:COG4886 311 LELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-242 3.13e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 3.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865   42 NCPESYPSAMYCDELKLKSVPM-VPPGIKYLYLRNNQIDHIDEKAFENVTDLQwlildhnllENSKIKGRVFSKLKQ-LK 119
Cdd:PRK15370 174 DCLKNNKTELRLKILGLTTIPAcIPEQITTLILDNNELKSLPENLQGNIKTLY---------ANSNQLTSIPATLPDtIQ 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  120 KLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSF--EGLVNL------------------TFIHLQHNRLK------- 172
Cdd:PRK15370 245 EMELSINRITELPERLPSALQSLDLFHNKISCLPENlpEELRYLsvydnsirtlpahlpsgiTHLNVQSNSLTalpetlp 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  173 ---------EDAVSAAFKGLK-SLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKrfnALQYLRLSHNELA 242
Cdd:PRK15370 325 pglktleagENALTSLPASLPpELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNLPENLPA---ALQIMQASRNNLV 401
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-200 5.76e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.12  E-value: 5.76e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  66 PGIKYLYLRNNQIDHIDekAFENVTDLQWLILDHNLLEnsKIKGrvFSKLKQLKKLHINHN------------NLTE--- 130
Cdd:cd21340  24 KNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE--KIEN--LENLVNLKKLYLGGNrisvveglenltNLEElhi 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 131 ----------------SVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKE-DAVSAAFKGLKSLEYLDLSF 193
Cdd:cd21340  98 enqrlppgekltfdprSLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDlEELLDLLSSWPSLRELDLTG 177


                ....*..
gi 13937865 194 NQIARLP 200
Cdd:cd21340 178 NPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-243 6.02e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.34  E-value: 6.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 112 FSKLKQLKKLHINHNNLT--ESVGPLPKsLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLkedAVSAAFKGLKSLEYL 189
Cdd:cd21340  20 LSLCKNLKVLYLYDNKITkiENLEFLTN-LTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI---SVVEGLENLTNLEEL 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13937865 190 DLSfNQiaRLPSGLPV------------SLLTLYLDNNKISNIpdEYFKRFNALQYLRLSHNELAD 243
Cdd:cd21340  96 HIE-NQ--RLPPGEKLtfdprslaalsnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISD 156
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-286 1.01e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 1.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  66 PGIKYLYLRNNQIDHIDEkAFENVTDLQWLILDHNLLENskiKGRVFSKLKQLKKLHINHNNLTE--SVGPLPKsLEDLQ 143
Cdd:COG4886 182 TNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNNQLTDlpELGNLTN-LEELD 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 144 LTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVS--AAFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIP 221
Cdd:COG4886 257 LSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13937865 222 DEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQL 286
Cdd:COG4886 337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 110-266 1.88e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 1.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  110 RVFSKLKQLKKLHINHNNLTESVGPLP---KSLEDLQLTHNKIT-KLGSFEGLVNLTFIHLQHNRLKEdAVSAAFKGLKS 185
Cdd:PLN00113 422 SEFTKLPLVYFLDISNNNLQGRINSRKwdmPSLQMLSLARNKFFgGLPDSFGSKRLENLDLSRNQFSG-AVPRKLGSLSE 500

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  186 LEYLDLSFNQIA-RLPSGLPV--SLLTLYLDNNKIS-NIPDEyFKRFNALQYLRLSHNELADSgIPGNSFNVSSLVELDL 261
Cdd:PLN00113 501 LMQLKLSENKLSgEIPDELSSckKLVSLDLSHNQLSgQIPAS-FSEMPVLSQLDLSQNQLSGE-IPKNLGNVESLVQVNI 578


                 ....*
gi 13937865  262 SYNKL 266
Cdd:PLN00113 579 SHNHL 583
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
31-321 9.26e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.71  E-value: 9.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865   31 GQSSPNCAPECnCPESYPSAMYCDElKLKSVPMVPPGIKYLYLRNNQIDHIDekafenvtdlqwlILDHNLLENSkIKGR 110
Cdd:PRK15387 209 GESGLTTLPDC-LPAHITTLVIPDN-NLTSLPALPPELRTLEVSGNQLTSLP-------------VLPPGLLELS-IFSN 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  111 VFSKLKQLK----KLHINHNNLTeSVGPLPKSLEDLQLTHNKITKLGSFEGlvNLTFIHLQHNRLkedavsAAFKGLKS- 185
Cdd:PRK15387 273 PLTHLPALPsglcKLWIFGNQLT-SLPVLPPGLQELSVSDNQLASLPALPS--ELCKLWAYNNQL------TSLPTLPSg 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  186 LEYLDLSFNQIARLPSgLPVSLLTLYLDNNKISNIPdeyfKRFNALQYLRLSHNELadSGIPgnsFNVSSLVELDLSYNK 265
Cdd:PRK15387 344 LQELSVSDNQLASLPT-LPSELYKLWAYNNRLTSLP----ALPSGLKELIVSGNRL--TSLP---VLPSELKELMVSGNR 413

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 13937865  266 LKNIPTVNENLENYYLEVNQLEKFDiKSFckilgpLSYSKIKHLRLDGNRISETSL 321
Cdd:PRK15387 414 LTSLPMLPSGLLSLSVYRNQLTRLP-ESL------IHLSSETTVNLEGNPLSERTL 462
LRR_8 pfam13855
Leucine rich repeat;
66-128 1.27e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.27e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13937865    66 PGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLenSKIKGRVFSKLKQLKKLHINHNNL 128
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 92-317 2.33e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.62  E-value: 2.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865   92 LQWLILDHNLLeNSKIKGRVFSKLKQLKKLHINHNNLTesvGPLPKS----LEDLQLTHNKIT-----KLGSFEglvNLT 162
Cdd:PLN00113  95 IQTINLSNNQL-SGPIPDDIFTTSSSLRYLNLSNNNFT---GSIPRGsipnLETLDLSNNMLSgeipnDIGSFS---SLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  163 FIHLQHNRLKeDAVSAAFKGLKSLEYLDLSFNQiarLPSGLPV------SLLTLYLDNNKIS-NIPDEY----------- 224
Cdd:PLN00113 168 VLDLGGNVLV-GKIPNSLTNLTSLEFLTLASNQ---LVGQIPRelgqmkSLKWIYLGYNNLSgEIPYEIggltslnhldl 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  225 ------------FKRFNALQYLRLSHNELADSgIPGNSFNVSSLVELDLSYNKLK-NIPTVNENLENyyLEVnqLEKFDI 291
Cdd:PLN00113 244 vynnltgpipssLGNLKNLQYLFLYQNKLSGP-IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQN--LEI--LHLFSN 318

                        250       260
                 ....*....|....*....|....*..
gi 13937865  292 KSFCKILGPL-SYSKIKHLRLDGNRIS 317
Cdd:PLN00113 319 NFTGKIPVALtSLPRLQVLQLWSNKFS 345
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 55-266 4.31e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.41  E-value: 4.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  55 ELKLKSVPMVPPGIKYLYLRNNQID------HIDEKAFENvTDLQWLILDHNLLENSKIK--GRVFSKLKQLKKLHINHN 126
Cdd:COG5238 140 RINLIQVLKDPLGGNAVHLLGLAARlgllaaISMAKALQN-NSVETVYLGCNQIGDEGIEelAEALTQNTTVTTLWLKRN 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 127 NLTES-------VGPLPKSLEDLQLTHNKITKLGS---FEGLVNLTFIH---LQHNRLKED---AVSAAFKGLKSLEYLD 190
Cdd:COG5238 219 PIGDEgaeilaeALKGNKSLTTLDLSNNQIGDEGVialAEALKNNTTVEtlyLSGNQIGAEgaiALAKALQGNTTLTSLD 298

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 191 LSFNQI-----ARLPSGLPVS--LLTLYLDNNKISNipDEYFKRFNALQY------LRLSHNELADSG-------IPGNs 250
Cdd:COG5238 299 LSVNRIgdegaIALAEGLQGNktLHTLNLAYNGIGA--QGAIALAKALQEnttlhsLDLSDNQIGDEGaialakyLEGN- 375

                       250
                ....*....|....*.
gi 13937865 251 fnvSSLVELDLSYNKL 266
Cdd:COG5238 376 ---TTLRELNLGKNNI 388
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-204 4.41e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.70  E-value: 4.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865   44 PESYPSAMYCDEL---KLKSVP-MVPPGIKYLYLRNNQIDHIDEKAFENVTDLqwlildhNLLENSkikgrvFSKLKQ-- 117
Cdd:PRK15370 257 PERLPSALQSLDLfhnKISCLPeNLPEELRYLSVYDNSIRTLPAHLPSGITHL-------NVQSNS------LTALPEtl 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  118 ---LKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGsfEGLV-NLTFIHLQHN---RLKEDAVSAafkglksLEYLD 190
Cdd:PRK15370 324 ppgLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLP--ETLPpTITTLDVSRNaltNLPENLPAA-------LQIMQ 394

                        170
                 ....*....|....
gi 13937865  191 LSFNQIARLPSGLP 204
Cdd:PRK15370 395 ASRNNLVRLPESLP 408
LRR_8 pfam13855
Leucine rich repeat;
206-266 6.94e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 6.94e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13937865   206 SLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELadSGIPGNSF-NVSSLVELDLSYNKL 266
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFsGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-317 1.34e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 142 LQLTHNKITKLGSFEGLVNLTFIHLQHNRLKEdavSAAFKGLKSLEYLDLSFNQIARLP--SGLPvSLLTLYLDNNKISN 219
Cdd:cd21340   7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITK---IENLEFLTNLTHLYLQNNQIEKIEnlENLV-NLKKLYLGGNRISV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 220 IpdEYFKRFNALQYLRLSHNELAdsgiPGNSF--------NVS-SLVELDLSYNKLKNI-PTVN-ENLENYYLEVNQLEk 288
Cdd:cd21340  83 V--EGLENLTNLEELHIENQRLP----PGEKLtfdprslaALSnSLRVLNISGNNIDSLePLAPlRNLEQLDASNNQIS- 155

                       170       180
                ....*....|....*....|....*....
gi 13937865 289 fDIKSFCKILGPLSYskIKHLRLDGNRIS 317
Cdd:cd21340 156 -DLEELLDLLSSWPS--LRELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
138-196 2.66e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 2.66e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13937865   138 SLEDLQLTHNKITKL--GSFEGLVNLTFIHLQHNRLKEDAvSAAFKGLKSLEYLDLSFNQI 196
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
37-71 8.24e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.00  E-value: 8.24e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 13937865     37 CAPECNCPesyPSAMYCDELKLKSVPMVPPGIKYL 71
Cdd:smart00013   2 CPAPCNCS---GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 37-66 1.07e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.54  E-value: 1.07e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 13937865    37 CAPECNCPesyPSAMYCDELKLKSVPMVPP 66
Cdd:pfam01462   2 CPVPCHCS---ATVVNCSDRGLTAVPRDLP 28
LRR_8 pfam13855
Leucine rich repeat;
117-171 1.59e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.59e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13937865   117 QLKKLHINHNNLTeSVGPL----PKSLEDLQLTHNKITKL--GSFEGLVNLTFIHLQHNRL 171
Cdd:pfam13855   2 NLRSLDLSNNRLT-SLDDGafkgLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 66-267 3.78e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 3.78e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  66 PGIKYLYLRNNQIDHIDEKAFENVT---DLQWLILDHNLLENS--KIKGRVFSKLK-QLKKLHINHNNLT-ESVGPLPK- 137
Cdd:cd00116  81 CGLQELDLSDNALGPDGCGVLESLLrssSLQELKLNNNGLGDRglRLLAKGLKDLPpALEKLVLGRNRLEgASCEALAKa 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 138 -----SLEDLQLTHNKITKLGS---FEGL---VNLTFIHLQHNRLKED---AVSAAFKGLKSLEYLDLSFNQI-----AR 198
Cdd:cd00116 161 lranrDLKELNLANNGIGDAGIralAEGLkanCNLEVLDLNNNGLTDEgasALAETLASLKSLEVLNLGDNNLtdagaAA 240

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13937865 199 LPSGLPV---SLLTLYLDNNKISNIPDEYFKRFnalqylrlshneLADSgipgnsfnvSSLVELDLSYNKLK 267
Cdd:cd00116 241 LASALLSpniSLLTLSLSCNDITDDGAKDLAEV------------LAEK---------ESLLELDLRGNKFG 291
LRR_8 pfam13855
Leucine rich repeat;
160-217 5.11e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 5.11e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13937865   160 NLTFIHLQHNRLKEDAVSAaFKGLKSLEYLDLSFNQIARLP----SGLPvSLLTLYLDNNKI 217
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGA-FKGLSNLKVLDLSNNLLTTLSpgafSGLP-SLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-266 5.72e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 5.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865   88 NVTDLQWLILDHNLLENSKikGRVFSKLKQLKKLHINHNNLTesvGPLPK------SLEDLQLTHNKITKL--GSFEGLV 159
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQI--PRELGQMKSLKWIYLGYNNLS---GEIPYeiggltSLNHLDLVYNNLTGPipSSLGNLK 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  160 NLTFIHLQHNRLKEDAVSAAFkGLKSLEYLDLSFN----QIARLPSGLPvSLLTLYLDNNKISNIPDEYFKRFNALQYLR 235
Cdd:PLN00113 261 NLQYLFLYQNKLSGPIPPSIF-SLQKLISLDLSDNslsgEIPELVIQLQ-NLEILHLFSNNFTGKIPVALTSLPRLQVLQ 338

                        170       180       190
                 ....*....|....*....|....*....|.
gi 13937865  236 LSHNELAdSGIPGNSFNVSSLVELDLSYNKL 266
Cdd:PLN00113 339 LWSNKFS-GEIPKNLGKHNNLTVLDLSTNNL 368
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 155-319 1.76e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 1.76e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 155 FEGLVNLTFIHLQHNRLKEDAVSAAFKGL---KSLEYLDLSFNQIARLPSGL---------PVSLLTLYLDNNKISniPD 222
Cdd:cd00116  19 LPKLLCLQVLRLEGNTLGEEAAKALASALrpqPSLKELCLSLNETGRIPRGLqsllqgltkGCGLQELDLSDNALG--PD 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865 223 -----EYFKRFNALQYLRLSHNELADSGIP----GNSFNVSSLVELDLSYNKLKNIPT--------VNENLENYYLEVNQ 285
Cdd:cd00116  97 gcgvlESLLRSSSLQELKLNNNGLGDRGLRllakGLKDLPPALEKLVLGRNRLEGASCealakalrANRDLKELNLANNG 176

                       170       180       190
                ....*....|....*....|....*....|....
gi 13937865 286 LEKFDIKSFCKILgpLSYSKIKHLRLDGNRISET 319
Cdd:cd00116 177 IGDAGIRALAEGL--KANCNLEVLDLNNNGLTDE 208
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 154-266 6.20e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 6.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13937865  154 SFEGLVNLTFIHLQHNRLKEDAVSAAFKGLKSLEYLDLSFNQIA-RLPSGLPVSLLTLYLDNNKIS-NIPDEyFKRFNAL 231
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSgEIPND-IGSFSSL 166

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 13937865  232 QYLRLSHNELADSgIPGNSFNVSSLVELDLSYNKL 266
Cdd:PLN00113 167 KVLDLGGNVLVGK-IPNSLTNLTSLEFLTLASNQL 200
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 137-174 5.81e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 5.81e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 13937865   137 KSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKED 174
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKITD 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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