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Conserved domains on  [gi|1391364757|gb|AWM51268|]
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galactokinase [Bacillus amyloliquefaciens]

Protein Classification

galactokinase( domain architecture ID 11480725)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05322 PRK05322
galactokinase; Provisional
 1-386 0e+00

galactokinase; Provisional


:

Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 643.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757   1 MDAKLLKSRFEDIFKRSNGDLFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFPDSGIVCLDL 80
Cdd:PRK05322    1 MMKEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLGIIEFDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  81 SATAYKKEDGWANYPKGVIHYLLKAGGQIDSGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKR 160
Cdd:PRK05322   81 DDLSFDKEDDWANYPKGVLKFLQEAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 161 VENEFIGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNELRSECDAALSELRQ 240
Cdd:PRK05322  161 TENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 241 YRNIASLAELTAEEFNELESLLSCETLRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDA 320
Cdd:PRK05322  241 KLDIKSLGELTEEEFDEYSYLIKDETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDT 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391364757 321 LAEAAWK-EGALGARMTGAGFGGCAIAIVENEETAGFIRAVSSHYRSRTGLEASFYIADISDGAAEW 386
Cdd:PRK05322  321 LVEAAWKqEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
 
Name Accession Description Interval E-value
PRK05322 PRK05322
galactokinase; Provisional
 1-386 0e+00

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 643.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757   1 MDAKLLKSRFEDIFKRSNGDLFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFPDSGIVCLDL 80
Cdd:PRK05322    1 MMKEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLGIIEFDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  81 SATAYKKEDGWANYPKGVIHYLLKAGGQIDSGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKR 160
Cdd:PRK05322   81 DDLSFDKEDDWANYPKGVLKFLQEAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 161 VENEFIGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNELRSECDAALSELRQ 240
Cdd:PRK05322  161 TENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 241 YRNIASLAELTAEEFNELESLLSCETLRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDA 320
Cdd:PRK05322  241 KLDIKSLGELTEEEFDEYSYLIKDETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDT 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391364757 321 LAEAAWK-EGALGARMTGAGFGGCAIAIVENEETAGFIRAVSSHYRSRTGLEASFYIADISDGAAEW 386
Cdd:PRK05322  321 LVEAAWKqEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
6-383 0e+00

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 550.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757   6 LKSRFEDIFKRSNGDLFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFPDSgiVCLDLSATAY 85
Cdd:COG0153     5 LIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEE--VEFDLDDLEP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  86 KKEDGWANYPKGVIHYLLKAGGQIdSGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKRVENEF 165
Cdd:COG0153    83 GEEDGWANYVRGVAWALQERGYKL-GGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAENEF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 166 IGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNELRSECDAALSELrqyrNIA 245
Cdd:COG0153   162 VGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAIL----GVK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 246 SLAELTAEEFNELESLLSCETLRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDALAEAA 325
Cdd:COG0153   238 SLRDVTLEDLEAARARLGDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELA 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1391364757 326 WKE-GALGARMTGAGFGGCAIAIVENEETAGFIRAVSSHYRSRTGLEASFYIADISDGA 383
Cdd:COG0153   318 LAEaGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 6-385 2.15e-131

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 381.86  E-value: 2.15e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757   6 LKSRFEDIFKRSNGDLFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFpDSGIVCLDLSATAY 85
Cdd:TIGR00131   4 IQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANA-DNKFAERSLDLPLD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  86 KKE-DGWANYPKGVIHYLLKAGGQIDSGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKRVENE 164
Cdd:TIGR00131  83 GSEvSDWANYFKGVLHVAQERFNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAENH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 165 FIGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNELRSECDAALSELRQyRNI 244
Cdd:TIGR00131 163 FVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAA-TDK 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 245 ASLAELTAEEFNELE---SLLSCETlRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDAL 321
Cdd:TIGR00131 242 GALRDFMNEYFARYIarlTKMLPLV-EERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDEL 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1391364757 322 AEAAW-KEGALGARMTGAGFGGCAIAIVENEETAGFIRAVSSHYRSRTGLEASFYIADISDGAAE 385
Cdd:TIGR00131 321 VCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGS 385
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 8-57 1.26e-19

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 81.34  E-value: 1.26e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1391364757   8 SRFEDIFKRSNGDLFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAK 57
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PRK05322 PRK05322
galactokinase; Provisional
 1-386 0e+00

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 643.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757   1 MDAKLLKSRFEDIFKRSNGDLFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFPDSGIVCLDL 80
Cdd:PRK05322    1 MMKEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLGIIEFDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  81 SATAYKKEDGWANYPKGVIHYLLKAGGQIDSGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKR 160
Cdd:PRK05322   81 DDLSFDKEDDWANYPKGVLKFLQEAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 161 VENEFIGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNELRSECDAALSELRQ 240
Cdd:PRK05322  161 TENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 241 YRNIASLAELTAEEFNELESLLSCETLRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDA 320
Cdd:PRK05322  241 KLDIKSLGELTEEEFDEYSYLIKDETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDT 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1391364757 321 LAEAAWK-EGALGARMTGAGFGGCAIAIVENEETAGFIRAVSSHYRSRTGLEASFYIADISDGAAEW 386
Cdd:PRK05322  321 LVEAAWKqEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
6-383 0e+00

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 550.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757   6 LKSRFEDIFKRSNGDLFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFPDSgiVCLDLSATAY 85
Cdd:COG0153     5 LIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEE--VEFDLDDLEP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  86 KKEDGWANYPKGVIHYLLKAGGQIdSGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKRVENEF 165
Cdd:COG0153    83 GEEDGWANYVRGVAWALQERGYKL-GGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAENEF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 166 IGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNELRSECDAALSELrqyrNIA 245
Cdd:COG0153   162 VGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAIL----GVK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 246 SLAELTAEEFNELESLLSCETLRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDALAEAA 325
Cdd:COG0153   238 SLRDVTLEDLEAARARLGDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELA 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1391364757 326 WKE-GALGARMTGAGFGGCAIAIVENEETAGFIRAVSSHYRSRTGLEASFYIADISDGA 383
Cdd:COG0153   318 LAEaGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGA 376
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 6-385 2.15e-131

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 381.86  E-value: 2.15e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757   6 LKSRFEDIFKRSNGDLFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFpDSGIVCLDLSATAY 85
Cdd:TIGR00131   4 IQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANA-DNKFAERSLDLPLD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  86 KKE-DGWANYPKGVIHYLLKAGGQIDSGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKRVENE 164
Cdd:TIGR00131  83 GSEvSDWANYFKGVLHVAQERFNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAENH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 165 FIGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAFNGYKIVIMNTNKRRELAASKYNELRSECDAALSELRQyRNI 244
Cdd:TIGR00131 163 FVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAA-TDK 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 245 ASLAELTAEEFNELE---SLLSCETlRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDAL 321
Cdd:TIGR00131 242 GALRDFMNEYFARYIarlTKMLPLV-EERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEIDEL 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1391364757 322 AEAAW-KEGALGARMTGAGFGGCAIAIVENEETAGFIRAVSSHYRSRTGLEASFYIADISDGAAE 385
Cdd:TIGR00131 321 VCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGS 385
PRK05101 PRK05101
galactokinase; Provisional
 5-383 3.65e-130

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 378.50  E-value: 3.65e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757   5 LLKSRFEDIFKRSNGDLFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFpDSGIVCLDLSAT- 83
Cdd:PRK05101    6 KTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADY-DNQQDEFSLDAPi 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  84 AYKKEDGWANYPKGVIHYLLKAGGQIdSGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKRVEN 163
Cdd:PRK05101   85 VPHPEQQWANYVRGVVKHLQERNPDF-GGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEAEN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 164 EFIGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAfNGYKIVIMNTNKRRELAASKYNELRSECDAAlselRQYRN 243
Cdd:PRK05101  164 QFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMP-EGVAVVIINSNVKRGLVDSEYNTRRQQCETA----ARFFG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 244 IASLAELTAEEFNELESLLScETLRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDALAE 323
Cdd:PRK05101  239 VKALRDVTLEQFNAVAAELD-PVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDTLVE 317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1391364757 324 AAW----KEGalGARMTGAGFGGCAIAIVENEETAGFIRAVSSHYRSRTGLEASFYIADISDGA 383
Cdd:PRK05101  318 IVKavigDQG--GVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGA 379
PRK03817 PRK03817
galactokinase; Provisional
 24-383 1.25e-108

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 322.72  E-value: 1.25e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  24 APGRINLIGEHTDYIGGHVLPCAITIgtYAVCAKRGDHQIRLYSENFPDSGIVCLDlsatAYKKEDGWANYPKGVIHYLL 103
Cdd:PRK03817    5 SPGRVNLIGEHTDYNDGYVLPFAINL--YTFLEIEKSEKFIFYSENFNEEKTFELD----KLEKLNSWADYIKGVIWVLE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 104 KAGGQIdSGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKRVENEFIGVNSGIMDQFAVQKGKK 183
Cdd:PRK03817   79 KRGYEV-GGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFGKK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 184 NMAILLNCDKLEHEMIPaaFN-GYKIVIMNTNKRRELAASKYNELRSECDAALSELrqyrNIASLAELTAEEFNELESLL 262
Cdd:PRK03817  158 DHAIFLDTMTLEYEYVP--FPeDYEILVFDTGVKRELASSEYNERRQECEEALKIL----GKKSSKEVTEEDLSKLPPLL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 263 scetlRKRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDALAEAAWKEGALGARMTGAGFGG 342
Cdd:PRK03817  232 -----RKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGG 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1391364757 343 CAIAIVENEETAGFIRAVSSHYRSRTGLEASFYIADISDGA 383
Cdd:PRK03817  307 SAIALVDKGKFESIGEELLEEYKKRFGIDPKYFVVESSDGV 347
PRK00555 PRK00555
galactokinase; Provisional
 22-348 1.33e-65

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 212.80  E-value: 1.33e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  22 FFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFPDSGIVCLDlsaTAYKKEDGWANYPKGVIHY 101
Cdd:PRK00555    5 YAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRADGSARIPLD---TTPGQVTGWAAYAAGVIWA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 102 LLKAGGQIDSG-MDILfhGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKRVENEFIGVNSGIMDQFAVQK 180
Cdd:PRK00555   82 LRGAGHPVPGGaMSIT--SDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENEYVGAPTGLLDQLAALF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 181 GKKNMAILLncDKLEHEMIPAAFN----GYKIVIMNTNKRRELAASKYNELRSECDAALSELrqyrNIASLAELTAEEFN 256
Cdd:PRK00555  160 GAPKTALLI--DFRDLTVRPVAFDpdaaGVVLLLMDSRARHRHAGGEYAARRASCERAAADL----GVSSLRAVQDRGLA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 257 ELESLLSCETLRkRARHAVNENERTLSAAEALKSNDLKTFGELMNASHRSLRDDYEVTGDELDALAEAAWKEGALGARMT 336
Cdd:PRK00555  234 ALGAIADPIDAR-RARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMT 312

                         330
                  ....*....|..
gi 1391364757 337 GAGFGGCAIAIV 348
Cdd:PRK00555  313 GGGFGGCVIALV 324
PLN02521 PLN02521
galactokinase
 6-367 6.54e-50

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 175.28  E-value: 6.54e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757   6 LKSRFEDIFKRSNgDLFF-APGRINLIGEHTDYIGGHVLPCAITIGTyAVCAKRGDHQIRLYSENFPDSGIVC---LDLS 81
Cdd:PLN02521   35 LKAAFVEVYGAKP-DLFArSPGRVNLIGEHIDYEGYSVLPMAIRQDT-IVAIRRAEGSKKLRIANVNDKYTTCtfpADPD 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  82 ATAYKKEDGWANY----PKGVIHYLLKAGGQI--DSGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELA 155
Cdd:PLN02521  113 QEVDLANHKWGNYficgYKGVFEFLKSKGVDVgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVA 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 156 LIGKRVEnEFIGVNSGIMDQFAVQKGKKNMAILL-------NCDKLehemiPAafnGYKIVIMNT---NKRRELAASKYN 225
Cdd:PLN02521  193 QFTCKCE-RHIGTQSGGMDQAISIMAQQGVAKLIdfnpvraTDVQL-----PA---GGTFVIANSlaeSNKAVTAATNYN 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 226 ELRSEC---------------DAALSELRQYRN----IASLAE-------------------LTAEEFNEL--ESL---- 261
Cdd:PLN02521  264 NRVVECrlaaivlavklgmsaEEAISKVKTLSDveglCVSFAGshgssdpavavkellhegpYTAEEIEEIlgESLtsif 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 262 ---------LSCET---LRKRARHAVNENERTLSAAEALKSND-----LKTFGELMNASHRSLRDDYEVTGDELDALAEA 324
Cdd:PLN02521  344 knsptslavLKAAKhfkLHQRAVHVYSEAKRVHAFRDTVSSSLseeekLKKLGDLMNESHYSCSVLYECSCPELEELVKV 423

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1391364757 325 AWKEGALGARMTGAGFGGCAIAIVENEETAGFIRAVS-SHYRSR 367
Cdd:PLN02521  424 CRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKeKFYKSR 467
PTZ00290 PTZ00290
galactokinase; Provisional
 6-383 2.08e-44

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 159.60  E-value: 2.08e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757   6 LKSRFEDIFKRSNGD-----LF-FAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRG---DHQIRLYSENFPdsgiv 76
Cdd:PTZ00290   18 LKPIFLETFKVENDAdvewlLFtFAPGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRVKhfcDHKLRFATETDE----- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  77 CLDLSATAYKKED-GWANYPKGVIHYLL-KAGGQID----SGMDILFHGTIPNGAGLSSSAS-----IEMLTGSILRKLF 145
Cdd:PTZ00290   93 HFVLDHLGGAKHNkAWTTFVRGAATLRLnRLGVAIDapslQGVCMVVHGTLPMGAGMSASASfgvalLNAINTVVTRRYK 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 146 SLDVSD---------------TELALIGKRVENEFIGVNSGIMDQFAVQKGKKNMAILLNCDKLEHE---MIPAAFNGYK 207
Cdd:PTZ00290  173 GCPTSPgrrysilppmskeelIELAKQARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFEshdMTPLLGDGAC 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 208 IVIMNTNKRREL---AASKYNELRSECDAALSELRQ--YRNIA-SLAELT-----------AEEF-NELESLLS------ 263
Cdd:PTZ00290  253 FLLIDSMIKHDLlggTAGMYNTVRSDQEGAQKKIGKhrYRGKPfTFSDLVrnpkkytfdgdVVAFmESCKPLMTpgefer 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 264 -----CETLRKRARHAVNENERTLSAAEALKSNdlktfGELMNASHRSLRDDYEVTGDELDALAEAA-WKEGALGARMTG 337
Cdd:PTZ00290  333 gtyniMEQIRTLEFIKLNDPELPLSREERFRKA-----GEILNAGHQGMRDLMKITTPELDFIHELInEEKGVAGGRMMG 407

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1391364757 338 AGFGGCAIAIVENEETAGFIRAVSSHYRSRTGLEASFYIADISDGA 383
Cdd:PTZ00290  408 GGFGGCIILLLKKNAVDRVVAHVREKFKARFGVENDVYPVVAGDGA 453
PLN02865 PLN02865
galactokinase
 6-359 3.77e-44

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 158.04  E-value: 3.77e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757   6 LKSRFEDIFKRSNGDLFF--APGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFPdsGIVCLDL--- 80
Cdd:PLN02865   15 IRERVAAMSGRNSGEVRVvvSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFE--GEVRFRVdei 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  81 -----SATAYKKEDG-WANYPKGVIHYLLKAGGQIDSGmdilFHGTIP-----NGAGLSSSASIEMLTGSILRKLFSLDV 149
Cdd:PLN02865   93 qhpiaNVSSDSKEESnWGDYARGAVYALQSRGHALSQG----ITGYISgseglDSSGLSSSAAVGVAYLLALENANNLTV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 150 SDTELALIGKRVENEFIGVNSGIMDQFAVQKGKKNMAILLNCDKLEHEMIPAAFNG------YKIVIMNTNKRRELAA-S 222
Cdd:PLN02865  169 SPEDNIELDRLIENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQpggekpFKILLAFSGLRHALTNkP 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 223 KYNELRSECDAALSELRQY----RNIASLAELTAEEFNELESLLScETLRKRARHAVNENERTLSAAEALKSNDLKTFGE 298
Cdd:PLN02865  249 GYNLRVSECQEAARFLLEAsgndELEPLLCNVEPEVYEAHKCKLE-AVLARRAEHYFSENMRVIKGVEAWASGNLEEFGK 327

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1391364757 299 LMNASHRSLRDDYEVTGDELDALAEAAWKE-GALGARMTGAGFGGCAIAIVEN---EETAGFIRA 359
Cdd:PLN02865  328 LISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRGCCVAFVDAemaEEAASFVRD 392
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 24-348 1.02e-29

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 115.71  E-value: 1.02e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  24 APGRINLIGEHTDYIGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFPDSgivcLDLSATAYKKEDgwanYPKGVIHYLL 103
Cdd:COG1577     1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGGT----LDLDPLADAALR----YIKAAIEAAL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 104 KAGGQIDSGMDILFHGTIPNGAGLSSSASIemlTGSILRKLFSL---DVSDTELALIGKRVENEFIGVNSGiMDQFAVQK 180
Cdd:COG1577    73 EYLGLPLKGFDIEIDSEIPRKRGLGSSAAV---AVAVIRALAAFygvELSKEELFKLALEAEKIVHGNPSG-LDTAASTY 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 181 GKknmAILLNCDKLEhEMIPAAFNGYkIVIMNTNKRRELAAskynelrsecdaALSELRQYRniaslaeltaeefneles 260
Cdd:COG1577   149 GG---PIYYQRGDRA-EPLELPKNLP-LVVGDTGVPASTKE------------LVAKVRKLK------------------ 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 261 llscETLRKRARHAVNENER-TLSAAEALKSNDLKTFGELMNASHRsLRDDYEVTGDELDALAEAAWKEGALGARMTGAG 339
Cdd:COG1577   194 ----ERNPELYEAFLEEIGDlVEEAIEALEEGDLEALGELMNENHG-LLRALGVSTPELDRLVEAARKAGALGAKLTGAG 268


                  ....*....
gi 1391364757 340 FGGCAIAIV 348
Cdd:COG1577   269 GGGCVIALA 277
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 24-346 8.49e-26

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 105.07  E-value: 8.49e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  24 APGRINLIGEHTDYIGGHVLPCAITIGTYAVcakrgdhqirlYSENFPDSGIVCLDLSATAYKKEDGWANYPKGVIHYLL 103
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVT-----------VIESSDGSFIESDLGRGSLDDAPDELDGLKYVLAEFLS 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 104 KAGGQIDSGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKRVENEFIGVNSGImDQFAVQKGKk 183
Cdd:TIGR00549  70 RFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGI-DTATSTSGG- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 184 nmAILLNCDKLEHEmIPAAFNGYkIVIMNTNKRRELAaskynelrsECDAALSELRQyrniaSLAELTAEEFNELESLls 263
Cdd:TIGR00549 148 --PVYFEKGEGEFT-KLISLDGY-FVIADTGVSGSTK---------EAVARVRQLLE-----RFPELIDSIMDAIGEL-- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 264 cetlrkrarhavnenerTLSAAEALKSNDLKTFGELMNASHrSLRDDYEVTGDELDALAEAAWKEGALGARMTGAGFGGC 343
Cdd:TIGR00549 208 -----------------TLEAKAALQDGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGC 269


                  ...
gi 1391364757 344 AIA 346
Cdd:TIGR00549 270 MIA 272
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 24-351 6.69e-24

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 100.64  E-value: 6.69e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  24 APGRINLIGEHTDY------IGGHVLPCAITIGTYAVCAKRGDHQIRLYSENFpdsGIVcldlsatayKKEDGWANYPKG 97
Cdd:COG2605     5 APLRISFAGGGTDLppyyleHGGAVLNAAIDKYAYVTLEPRFDGKIRLSSSDT---ERV---------ETVDEDDDIPHP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  98 VIHYLLKAGGqIDSGMDILFHGTIPNGAGLSSSASieMLTGSI--LRKLFSLDVSDTELALIGKRVENEFIGVNSGIMDQ 175
Cdd:COG2605    73 VIREALKLFG-IGDGLEITTDSDAPAGSGLGSSSA--LTVALLnaLHALLGLPLSPYDLARLAYEIERNDLGEPGGKQDQ 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 176 FAvqkgkknmaillncdklehemipAAFNGYKIVIMNTNKRrelaaSKYNELRsecdaalselrqyrniaslaeLTAEEF 255
Cdd:COG2605   150 YA-----------------------AAFGGFNFIEFGPDGR-----VIVNPLR---------------------ISPEIL 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 256 NELES--LL--------SCETLRKRARHAVNENERTLSA-----------AEALKSNDLKTFGELMNAS---HRSLRDDy 311
Cdd:COG2605   181 NELESnlLLfytgitreSSDILKEQVKNVEDGDEATLEAlhemkelalemKEALLKGDLDEFGELLNEGwelKKRLASG- 259

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1391364757 312 eVTGDELDALAEAAWKEGALGARMTGAGFGGCAIAIVENE 351
Cdd:COG2605   260 -ISNPAIDEIYELARKAGALGGKLLGAGGGGFLLFYAPPE 298
PRK03926 PRK03926
mevalonate kinase; Provisional
 24-362 6.02e-23

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 97.82  E-value: 6.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757  24 APGRINLIGEHTDYIGGHVLPCAITIGTYaVCAKRGDHQIRLYSEnfpdsgivcldlsataYKKEDGWANYPKGVIHYLL 103
Cdd:PRK03926    6 APGKIYLFGEHAVVYGKPAIACAIDLRTY-VRAEFNDDSIYIESD----------------YGKTGEKHPYVSAAIEKMR 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 104 KAGgQIDsGMDILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDVSDTELALIGKRVENEFIGVNSGImDQFA------ 177
Cdd:PRK03926   69 EEA-DKD-GVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPT-DTYVstmggf 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 178 --VQKGKKnmaillncdkLEhemipaaFNGYKIVIMNTNKrrelaaskynelrsecDAALSELrqyrnIASLAELTaEEF 255
Cdd:PRK03926  146 vtIPDRKK----------LP-------FPECGIVVGYTGS----------------SGSTKEL-----VANVRKLK-EEY 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 256 NEL-ESLLSC-ETLRKRARhavnenertlsaaEALKSNDLKTFGELMNASHrSLRDDYEVTGDELDALAEAAWKEGALGA 333
Cdd:PRK03926  187 PELiEPILSSiGKISEKGE-------------ELILSGDYVSLGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGA 252

                         330       340
                  ....*....|....*....|....*....
gi 1391364757 334 RMTGAGFGGCAIAIVENEETAGFIRAVSS 362
Cdd:PRK03926  253 KITGAGGGGCMVALAAPEKQSEVATAIKI 281
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 8-57 1.26e-19

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 81.34  E-value: 1.26e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1391364757   8 SRFEDIFKRSNGDLFFAPGRINLIGEHTDYIGGHVLPCAITIGTYAVCAK 57
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 284-365 1.81e-12

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 62.49  E-value: 1.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 284 AAEALKSNDLKTFGELMNASHRSL--RDDYEVTGDELDALAEAAWKEGaLGARMTGAGFGGCAIAIVENEETAGFI-RAV 360
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELG-LGAKLSGSGGGPTVFALFKDEDDAEEVaRAL 79


                  ....*
gi 1391364757 361 SSHYR 365
Cdd:pfam08544  80 REAGK 84
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 114-178 3.96e-10

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 55.25  E-value: 3.96e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1391364757 114 DILFHGTIPNGAGLSSSASIEMLTGSILRKLFSLDvsdteLALIGKRVENEFIGVNSGIMDQFAV 178
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLP-----LAKLALEAEELAGGGRGGGMDVAAS 60
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 243-352 6.57e-09

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 56.78  E-value: 6.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1391364757 243 NIASLAELTAEEFNELesllsCEtlrkRARHAVNEnertlsAAEALKSNDLKTFGELMNASHRSLRDdYEVTGDELDALA 322
Cdd:PTZ00298  204 DVRKLKENQPTWFNRL-----LE----NYNACVSE------AKEALQKGNLFRVGELMNANHDLCQK-LTVSCRELDSIV 267

                          90       100       110
                  ....*....|....*....|....*....|
gi 1391364757 323 EAAWKEGALGARMTGAGFGGCAIAIVENEE 352
Cdd:PTZ00298  268 QTCRTYGALGAKMSGTGRGGLVVALAASED 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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