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Conserved domains on  [gi|1390924781|gb|AWM12268|]
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Toll-like receptor 4, partial [Emberiza citrinella]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-226 5.33e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 5.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390924781  55 IGNISTIRLVDLGLEQISEVPVG----SKVKQLECKKCGFDDVPAlKLSLFKELRVLRITKNRsLKNFKQKFEGLSNLEV 130
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEElanlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390924781 131 IDLSENRLTFSrccSPQFRNCPNLKYLNLSFNSYIRLTEDFTNVENLLYLDFQHTTLfgpGSYPVFLSLQRLIYLDISHT 210
Cdd:COG4886   187 LDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260

                         170
                  ....*....|....*..
gi 1390924781 211 K-TEVKSQCTFCGLNSL 226
Cdd:COG4886   261 QlTDLPPLANLTNLKTL 277
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-226 5.33e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 5.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390924781  55 IGNISTIRLVDLGLEQISEVPVG----SKVKQLECKKCGFDDVPAlKLSLFKELRVLRITKNRsLKNFKQKFEGLSNLEV 130
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEElanlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390924781 131 IDLSENRLTFSrccSPQFRNCPNLKYLNLSFNSYIRLTEDFTNVENLLYLDFQHTTLfgpGSYPVFLSLQRLIYLDISHT 210
Cdd:COG4886   187 LDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260

                         170
                  ....*....|....*..
gi 1390924781 211 K-TEVKSQCTFCGLNSL 226
Cdd:COG4886   261 QlTDLPPLANLTNLKTL 277
LRR_8 pfam13855
Leucine rich repeat;
103-162 5.78e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 5.78e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1390924781 103 ELRVLRITKNRSLKNFKQKFEGLSNLEVIDLSENRLTFSrccSPQ-FRNCPNLKYLNLSFN 162
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTL---SPGaFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-162 7.43e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 7.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1390924781  90 FDdvPALKLSLFKELRVLRITKNR--SLKNFkqkfEGLSNLEVIDLSENRLTFSRCCSPQFRNCPNLKYLNLSFN 162
Cdd:cd21340   110 FD--PRSLAALSNSLRVLNISGNNidSLEPL----APLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-226 5.33e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 5.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390924781  55 IGNISTIRLVDLGLEQISEVPVG----SKVKQLECKKCGFDDVPAlKLSLFKELRVLRITKNRsLKNFKQKFEGLSNLEV 130
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEElanlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKE 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390924781 131 IDLSENRLTFSrccSPQFRNCPNLKYLNLSFNSYIRLTEDFTNVENLLYLDFQHTTLfgpGSYPVFLSLQRLIYLDISHT 210
Cdd:COG4886   187 LDLSNNQITDL---PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL---TDLPELGNLTNLEELDLSNN 260

                         170
                  ....*....|....*..
gi 1390924781 211 K-TEVKSQCTFCGLNSL 226
Cdd:COG4886   261 QlTDLPPLANLTNLKTL 277
LRR_8 pfam13855
Leucine rich repeat;
103-162 5.78e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 5.78e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1390924781 103 ELRVLRITKNRSLKNFKQKFEGLSNLEVIDLSENRLTFSrccSPQ-FRNCPNLKYLNLSFN 162
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTL---SPGaFSGLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-162 7.43e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 7.43e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1390924781  90 FDdvPALKLSLFKELRVLRITKNR--SLKNFkqkfEGLSNLEVIDLSENRLTFSRCCSPQFRNCPNLKYLNLSFN 162
Cdd:cd21340   110 FD--PRSLAALSNSLRVLNISGNNidSLEPL----APLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 127-173 1.01e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1390924781 127 NLEVIDLSENRLTFSrccsPQFRNCPNLKYLNLSFNSYIRLTEDFTN 173
Cdd:pfam12799   2 NLEVLDLSNNQITDI----PPLAKLPNLETLDLSGNNKITDLSDLAN 44
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-211 5.71e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.22  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390924781  96 LKLSLFKELRVLRITKNRSLKNFKQKFEGLSNLEVIDLSENRltfsrccspQFRNCPNLKYLNLSFNSYIRLTEDFTNVE 175
Cdd:COG4886    66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPEELANLT 136

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1390924781 176 NLLYLDFQHTTLfgpGSYPVFLS-LQRLIYLDISHTK 211
Cdd:COG4886   137 NLKELDLSNNQL---TDLPEPLGnLTNLKSLDLSNNQ 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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