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Conserved domains on  [gi|1390086044|ref|XP_025003790|]
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acidic amino acid decarboxylase GADL1 isoform X2 [Gallus gallus]

Protein Classification

pyridoxal phosphate-dependent decarboxylase family protein( domain architecture ID 10000562)

pyridoxal phosphate-dependent decarboxylase family protein is primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but it is also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters

CATH:  3.40.640.10
EC:  4.1.1.-
Gene Ontology:  GO:0016830|GO:0030170|GO:0019752
PubMed:  8690703|7748903
SCOP:  4003328

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 19-464 1.67e-144

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


:

Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 421.16  E-value: 1.67e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  19 RAPETLKKILDLEMRDTGESHQKLLQ-LCQDVIQYSVKTNHPRFFNQLYAGIDYYSLVARFITEALNPSVYTYEVSPVFL 97
Cdd:COG0076    27 PSPEELRAALDEPLPEEGLPPEEALAeLEDLVLPGSVDWNHPRFLAFVTGGTTPAALAADLLASALNQNMGDWDTSPAAT 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  98 LVEEAVIKKMIEFIGW-EEGDGIFNPGGSVSNMYAMNLARYKFCPE-IKEKGLSGLPRLVLFTSEECHYSMKKAASFLGI 175
Cdd:COG0076   107 ELEREVVRWLADLLGLpEGAGGVFTSGGTEANLLALLAARDRALARrVRAEGLPGAPRPRIVVSEEAHSSVDKAARLLGL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 176 GTENVYFVKTDERGKMIPEELEKQVQRARKEGSAPFLVCATAGTTVLGAFDPLDKIADICEKHDLWLHVDASWGGSALIS 255
Cdd:COG0076   187 GRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPS 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 256 RKHRRLLHGIQRADSVAWNPHKMLLAGIQCCALLVKDnSGLLKKCYSAKAAYLFQQDkfyDVSYDTGDKSIQCSRRPDAF 335
Cdd:COG0076   267 PELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRD-PELLREAFSFHASYLGPAD---DGVPNLGDYTLELSRRFRAL 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 336 KFWLMWKALGTTGLEERVNRALALARYLVEEIKKREGFQLLLEPEYANVCFWYIPPSLrkmedgPEFWQKLHRVApvvkE 415
Cdd:COG0076   343 KLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELNIVCFRYKPAGL------DEEDALNYALR----D 412

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1390086044 416 RMMKKGSMMLGYQPNQGKVNfFRQVVISPQVSREDMDFLLDEIELLAKD 464
Cdd:COG0076   413 RLRARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAAE 460
 
Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 19-464 1.67e-144

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 421.16  E-value: 1.67e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  19 RAPETLKKILDLEMRDTGESHQKLLQ-LCQDVIQYSVKTNHPRFFNQLYAGIDYYSLVARFITEALNPSVYTYEVSPVFL 97
Cdd:COG0076    27 PSPEELRAALDEPLPEEGLPPEEALAeLEDLVLPGSVDWNHPRFLAFVTGGTTPAALAADLLASALNQNMGDWDTSPAAT 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  98 LVEEAVIKKMIEFIGW-EEGDGIFNPGGSVSNMYAMNLARYKFCPE-IKEKGLSGLPRLVLFTSEECHYSMKKAASFLGI 175
Cdd:COG0076   107 ELEREVVRWLADLLGLpEGAGGVFTSGGTEANLLALLAARDRALARrVRAEGLPGAPRPRIVVSEEAHSSVDKAARLLGL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 176 GTENVYFVKTDERGKMIPEELEKQVQRARKEGSAPFLVCATAGTTVLGAFDPLDKIADICEKHDLWLHVDASWGGSALIS 255
Cdd:COG0076   187 GRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPS 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 256 RKHRRLLHGIQRADSVAWNPHKMLLAGIQCCALLVKDnSGLLKKCYSAKAAYLFQQDkfyDVSYDTGDKSIQCSRRPDAF 335
Cdd:COG0076   267 PELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRD-PELLREAFSFHASYLGPAD---DGVPNLGDYTLELSRRFRAL 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 336 KFWLMWKALGTTGLEERVNRALALARYLVEEIKKREGFQLLLEPEYANVCFWYIPPSLrkmedgPEFWQKLHRVApvvkE 415
Cdd:COG0076   343 KLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELNIVCFRYKPAGL------DEEDALNYALR----D 412

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1390086044 416 RMMKKGSMMLGYQPNQGKVNfFRQVVISPQVSREDMDFLLDEIELLAKD 464
Cdd:COG0076   413 RLRARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAAE 460
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 61-459 8.58e-128

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 374.23  E-value: 8.58e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  61 FFNQLYAGIDYYSLVARFITEALNPSVYTYEVSPVFLLVEEAVIKKMIEFIGW--EEGDGIFNPGGSVSNMYAMNLARYK 138
Cdd:cd06450     1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLpsEDADGVFTSGGSESNLLALLAARDR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 139 FCPEIKEKGLSGLPRLVLFTSEECHYSMKKAASFLGIgteNVYFVKTDERGKMIPEELEKQVQRARKEGSAPFLVCATAG 218
Cdd:cd06450    81 ARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATAG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 219 TTVLGAFDPLDKIADICEKHDLWLHVDASWGGSALISRKHRRLLHGIQRADSVAWNPHKMLLAGIQCCALLVKdnsgllk 298
Cdd:cd06450   158 TTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 299 kcysakaaylfqqdkfydvsydtgdksiqcsrrpdAFKFWLMWKALGTTGLEERVNRALALARYLVEEIKKREGFQLLLE 378
Cdd:cd06450   231 -----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGE 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 379 PEYANVCFWYIPPSlrkmedgpefwqKLHRVAPVVKERMMKKGSMMLGYQPnQGKVNFFRQVVISPQVSREDMDFLLDEI 458
Cdd:cd06450   276 PNLSLVCFRLKPSV------------KLDELNYDLSDRLNERGGWHVPATT-LGGPNVLRFVVTNPLTTRDDADALLEDI 342


                  .
gi 1390086044 459 E 459
Cdd:cd06450   343 E 343
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
21-389 2.54e-126

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 371.37  E-value: 2.54e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  21 PETLKKILDLEMRDTGESHQKLLQLCQDVIQYSVKTNH-PRFFNQLYAGIDYYSLVARFITEALNPSVYTYEVSPVFLLV 99
Cdd:pfam00282   1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 100 EEAVIKKMIEFIGW------EEGDGIFNPGGSVSNMYAMNLARYKFCPEIKEKG-----LSGLPRLVLFTSEECHYSMKK 168
Cdd:pfam00282  81 ENVVMNWLGEMLGLpaeflgQEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGkpadsSGILAKLVAYTSDQAHSSIEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 169 AASFLGIGtenVYFVKTDERGKMIPEELEKQVQRARKEGSAPFLVCATAGTTVLGAFDPLDKIADICEKHDLWLHVDASW 248
Cdd:pfam00282 161 AALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAY 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 249 GGSALISRKHRRLLHGIQRADSVAWNPHKMLLAGIQCCALLVKDnSGLLKKCYSAKAAYLFQQDKfydvSYDTGDKSIQC 328
Cdd:pfam00282 238 GGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKD-KEALQQAFQFNPLYLGHTDS----AYDTGHKQIPL 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1390086044 329 SRRPDAFKFWLMWKALGTTGLEERVNRALALARYLVEEIKKREGFQLLLEPEYANVCFWYI 389
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGLGLVCFRLK 373
PLN02590 PLN02590
probable tyrosine decarboxylase
 21-390 7.07e-43

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 159.11  E-value: 7.07e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  21 PETLKKILDLEMRDTGESHQKLLQ-LCQDVIQYSVKTNHPRFFnQLYAGidyYSLVARFITEALNPSV----YTYEVSPV 95
Cdd:PLN02590   92 PGYLRDMLPDSAPERPESLKELLDdVSKKIMPGITHWQSPSYF-AYYAS---STSVAGFLGEMLNAGLsvvgFTWLTSPA 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  96 FLLVEEAVIK---KMIE----FIGWEEGDGIFNPGGSVSNMYAMNLARYKFcpeIKEKGLSGLPRLVLFTSEECHYSMKK 168
Cdd:PLN02590  168 ATELEIIVLDwlaKLLQlpdhFLSTGNGGGVIQGTGCEAVLVVVLAARDRI---LKKVGKTLLPQLVVYGSDQTHSSFRK 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 169 AASFLGIGTENVYFVKTDERGK--MIPEELEKQVQRARKEGSAPFLVCATAGTTVLGAFDPLDKIADICEKHDLWLHVDA 246
Cdd:PLN02590  245 ACLIGGIHEENIRLLKTDSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDA 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 247 SWGGSALISRKHRRLLHGIQRADSVAWNPHKMLLAGIQCCALLVKDNSGLLKKCYSAKAAYLFQQDKfYDVSYDTGDKSI 326
Cdd:PLN02590  325 AYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSK-KDTVVNYKDWQI 403

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1390086044 327 QCSRRPDAFKFWLMWKALGTTGLEERVNRALALARYLVEEIKKREGFQLLLEPEYANVCFWYIP 390
Cdd:PLN02590  404 SLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRLAP 467
 
Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 19-464 1.67e-144

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 421.16  E-value: 1.67e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  19 RAPETLKKILDLEMRDTGESHQKLLQ-LCQDVIQYSVKTNHPRFFNQLYAGIDYYSLVARFITEALNPSVYTYEVSPVFL 97
Cdd:COG0076    27 PSPEELRAALDEPLPEEGLPPEEALAeLEDLVLPGSVDWNHPRFLAFVTGGTTPAALAADLLASALNQNMGDWDTSPAAT 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  98 LVEEAVIKKMIEFIGW-EEGDGIFNPGGSVSNMYAMNLARYKFCPE-IKEKGLSGLPRLVLFTSEECHYSMKKAASFLGI 175
Cdd:COG0076   107 ELEREVVRWLADLLGLpEGAGGVFTSGGTEANLLALLAARDRALARrVRAEGLPGAPRPRIVVSEEAHSSVDKAARLLGL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 176 GTENVYFVKTDERGKMIPEELEKQVQRARKEGSAPFLVCATAGTTVLGAFDPLDKIADICEKHDLWLHVDASWGGSALIS 255
Cdd:COG0076   187 GRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPS 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 256 RKHRRLLHGIQRADSVAWNPHKMLLAGIQCCALLVKDnSGLLKKCYSAKAAYLFQQDkfyDVSYDTGDKSIQCSRRPDAF 335
Cdd:COG0076   267 PELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRD-PELLREAFSFHASYLGPAD---DGVPNLGDYTLELSRRFRAL 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 336 KFWLMWKALGTTGLEERVNRALALARYLVEEIKKREGFQLLLEPEYANVCFWYIPPSLrkmedgPEFWQKLHRVApvvkE 415
Cdd:COG0076   343 KLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELNIVCFRYKPAGL------DEEDALNYALR----D 412

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1390086044 416 RMMKKGSMMLGYQPNQGKVNfFRQVVISPQVSREDMDFLLDEIELLAKD 464
Cdd:COG0076   413 RLRARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAAE 460
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 61-459 8.58e-128

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 374.23  E-value: 8.58e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  61 FFNQLYAGIDYYSLVARFITEALNPSVYTYEVSPVFLLVEEAVIKKMIEFIGW--EEGDGIFNPGGSVSNMYAMNLARYK 138
Cdd:cd06450     1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLpsEDADGVFTSGGSESNLLALLAARDR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 139 FCPEIKEKGLSGLPRLVLFTSEECHYSMKKAASFLGIgteNVYFVKTDERGKMIPEELEKQVQRARKEGSAPFLVCATAG 218
Cdd:cd06450    81 ARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATAG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 219 TTVLGAFDPLDKIADICEKHDLWLHVDASWGGSALISRKHRRLLHGIQRADSVAWNPHKMLLAGIQCCALLVKdnsgllk 298
Cdd:cd06450   158 TTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 299 kcysakaaylfqqdkfydvsydtgdksiqcsrrpdAFKFWLMWKALGTTGLEERVNRALALARYLVEEIKKREGFQLLLE 378
Cdd:cd06450   231 -----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGE 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 379 PEYANVCFWYIPPSlrkmedgpefwqKLHRVAPVVKERMMKKGSMMLGYQPnQGKVNFFRQVVISPQVSREDMDFLLDEI 458
Cdd:cd06450   276 PNLSLVCFRLKPSV------------KLDELNYDLSDRLNERGGWHVPATT-LGGPNVLRFVVTNPLTTRDDADALLEDI 342


                  .
gi 1390086044 459 E 459
Cdd:cd06450   343 E 343
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
21-389 2.54e-126

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 371.37  E-value: 2.54e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  21 PETLKKILDLEMRDTGESHQKLLQLCQDVIQYSVKTNH-PRFFNQLYAGIDYYSLVARFITEALNPSVYTYEVSPVFLLV 99
Cdd:pfam00282   1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 100 EEAVIKKMIEFIGW------EEGDGIFNPGGSVSNMYAMNLARYKFCPEIKEKG-----LSGLPRLVLFTSEECHYSMKK 168
Cdd:pfam00282  81 ENVVMNWLGEMLGLpaeflgQEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGkpadsSGILAKLVAYTSDQAHSSIEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 169 AASFLGIGtenVYFVKTDERGKMIPEELEKQVQRARKEGSAPFLVCATAGTTVLGAFDPLDKIADICEKHDLWLHVDASW 248
Cdd:pfam00282 161 AALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAY 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 249 GGSALISRKHRRLLHGIQRADSVAWNPHKMLLAGIQCCALLVKDnSGLLKKCYSAKAAYLFQQDKfydvSYDTGDKSIQC 328
Cdd:pfam00282 238 GGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKD-KEALQQAFQFNPLYLGHTDS----AYDTGHKQIPL 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1390086044 329 SRRPDAFKFWLMWKALGTTGLEERVNRALALARYLVEEIKKREGFQLLLEPEYANVCFWYI 389
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGLGLVCFRLK 373
PLN02590 PLN02590
probable tyrosine decarboxylase
 21-390 7.07e-43

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 159.11  E-value: 7.07e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  21 PETLKKILDLEMRDTGESHQKLLQ-LCQDVIQYSVKTNHPRFFnQLYAGidyYSLVARFITEALNPSV----YTYEVSPV 95
Cdd:PLN02590   92 PGYLRDMLPDSAPERPESLKELLDdVSKKIMPGITHWQSPSYF-AYYAS---STSVAGFLGEMLNAGLsvvgFTWLTSPA 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  96 FLLVEEAVIK---KMIE----FIGWEEGDGIFNPGGSVSNMYAMNLARYKFcpeIKEKGLSGLPRLVLFTSEECHYSMKK 168
Cdd:PLN02590  168 ATELEIIVLDwlaKLLQlpdhFLSTGNGGGVIQGTGCEAVLVVVLAARDRI---LKKVGKTLLPQLVVYGSDQTHSSFRK 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 169 AASFLGIGTENVYFVKTDERGK--MIPEELEKQVQRARKEGSAPFLVCATAGTTVLGAFDPLDKIADICEKHDLWLHVDA 246
Cdd:PLN02590  245 ACLIGGIHEENIRLLKTDSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDA 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 247 SWGGSALISRKHRRLLHGIQRADSVAWNPHKMLLAGIQCCALLVKDNSGLLKKCYSAKAAYLFQQDKfYDVSYDTGDKSI 326
Cdd:PLN02590  325 AYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSK-KDTVVNYKDWQI 403

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1390086044 327 QCSRRPDAFKFWLMWKALGTTGLEERVNRALALARYLVEEIKKREGFQLLLEPEYANVCFWYIP 390
Cdd:PLN02590  404 SLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRLAP 467
PLN02880 PLN02880
tyrosine decarboxylase
 21-392 3.12e-41

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 153.53  E-value: 3.12e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  21 PETLKKILDLEMRDTGESHQKLLQLCQDVIQYSVKT-NHPRFFNqlyagidYY---SLVARFITEALNPSV----YTYEV 92
Cdd:PLN02880   44 PGYLRELLPDSAPNQPETLDQVLDDVQAKILPGVTHwQSPNYFA-------YYpsnSSVAGFLGEMLSAGLnivgFSWIT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  93 SPVFLLVEEAVIK---KMI----EFIGWEEGDGIFNPGGSVSNMYAMNLARYKFcpeIKEKGLSGLPRLVLFTSEECHYS 165
Cdd:PLN02880  117 SPAATELEMIVLDwlaKLLnlpeQFLSTGNGGGVIQGTASEAVLVVLLAARDRV---LRKVGKNALEKLVVYASDQTHSA 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 166 MKKAASFLGIGTENVYFVKTDERGK--MIPEELEKQVQRARKEGSAPFLVCATAGTTVLGAFDPLDKIADICEKHDLWLH 243
Cdd:PLN02880  194 LQKACQIAGIHPENCRLLKTDSSTNyaLAPELLSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFH 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 244 VDASWGGSALISRKHRRLLHGIQRADSVAWNPHKMLLAGIQCCALLVKDNSGLLKKcYSAKAAYLFQQDKFYDVSYDTGD 323
Cdd:PLN02880  274 VDAAYAGSACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWVKDRNALIQS-LSTNPEFLKNKASQANSVVDYKD 352

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1390086044 324 KSIQCSRRPDAFKFWLMWKALGTTGLEERVNRALALARYLVEEIKKREGFQLLLEPEYANVCFWYIPPS 392
Cdd:PLN02880  353 WQIPLGRRFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQDSRFEVVTPRIFSLVCFRLVPPK 421
PRK02769 PRK02769
histidine decarboxylase; Provisional
 72-458 9.77e-24

histidine decarboxylase; Provisional


Pssm-ID: 235068 [Multi-domain]  Cd Length: 380  Bit Score: 102.43  E-value: 9.77e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  72 YSLVARFITEALNPSVYTYEvSPVFLL----VEEAVIKKMIEF--IGWEEGDGIFNPGGSVSNMYAMNLARYKFcpeike 145
Cdd:PRK02769   36 YSALKRFFSFSINNCGDPYS-KSNYPLnsfdFERDVMNFFAELfkIPFNESWGYITNGGTEGNLYGCYLARELF------ 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 146 kglsglPRLVLFTSEECHYSMKKAASFLGIGTEnvyFVKTDERGKMIPEELEkqvQRARKEGSAPFLVCATAGTTVLGAF 225
Cdd:PRK02769  109 ------PDGTLYYSKDTHYSVSKIARLLRIKSR---VITSLPNGEIDYDDLI---SKIKENKNQPPIIFANIGTTMTGAI 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 226 DPLDKIADICEKH---DLWLHVDASWGGSALISRKHRRLL---HGIqraDSVAWNPHKMLLAGIQCCALLVKdnsgllKK 299
Cdd:PRK02769  177 DNIKEIQEILKKIgidDYYIHADAALSGMILPFVNNPPPFsfaDGI---DSIAISGHKFIGSPMPCGIVLAK------KK 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 300 cysakaaylfQQDKFY-DVSY-DTGDKSIQCSRrpDAFKFWLMWKA---LGTTGLEERVNRALALARYLVEEIKKReGFQ 374
Cdd:PRK02769  248 ----------YVERISvDVDYiGSRDQTISGSR--NGHTALLLWAAirsLGSKGLRQRVQHCLDMAQYAVDRLQAN-GIP 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 375 LLLEPEYANVCFwyippslrkmedgpefwqklhrvaPVVKERMMKKGSMmlgyqPNQGKVNffrQVVISPQVSREDMDFL 454
Cdd:PRK02769  315 AWRNPNSITVVF------------------------PCPSERIWKKWHL-----ATSGNQA---HIITMPHHNKQQIDSL 362


                  ....
gi 1390086044 455 LDEI 458
Cdd:PRK02769  363 IDEL 366
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 100-281 6.07e-10

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 58.16  E-value: 6.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 100 EEAVIKKMIEFIGWEEGDGIFNPGGSVSN-MYAMNLARYKfcpeikekglsglpRLVLFtSEECHYSmkKAASFLGIGTE 178
Cdd:cd01494     2 LEELEEKLARLLQPGNDKAVFVPSGTGANeAALLALLGPG--------------DEVIV-DANGHGS--RYWVAAELAGA 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 179 NVYFVKTDERGKMipeELEKQVQRARKEGSAPFLVCATAGTTVLGAFDPLDKIADICEKHDLWLHVDASWGGSALISRKH 258
Cdd:cd01494    65 KPVPVPVDDAGYG---GLDVAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGV 141

                         170       180
                  ....*....|....*....|...
gi 1390086044 259 RRllhGIQRADSVAWNPHKMLLA 281
Cdd:cd01494   142 LI---PEGGADVVTFSLHKNLGG 161
PLN03032 PLN03032
serine decarboxylase; Provisional
 124-368 4.90e-07

serine decarboxylase; Provisional


Pssm-ID: 166673 [Multi-domain]  Cd Length: 374  Bit Score: 51.75  E-value: 4.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 124 GSVSNMYAMNLARYKFcpeikekglsglPRLVLFTSEECHYSMKKAASFLGIGTENvyfVKTDERGKMIPEELEKQVQRA 203
Cdd:PLN03032   94 GTEGNLHGILVGREVF------------PDGILYASRESHYSVFKAARMYRMEAVK---VPTLPSGEIDYDDLERALAKN 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 204 RKEgsaPFLVCATAGTTVLGAFDPLDKIADICEK-----HDLWLHVDASWGGSALISRKHRRLLHGIQRADSVAWNPHKM 278
Cdd:PLN03032  159 RDK---PAILNVNIGTTVKGAVDDLDRILRILKElgyteDRFYIHCDGALFGLMMPFVSRAPEVTFRKPIGSVSVSGHKF 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 279 LLAGIQCCALLVKdnsgllkkcysAKAAYLFQQDKFYDVSYDTgdkSIQCSRRPDAFKF-WLMWKALGTTGLEERVNRAL 357
Cdd:PLN03032  236 LGCPMPCGVALTR-----------KKHVKALSQNVEYLNSRDA---TIMGSRNGHAPLYlWYTLRRKGYRGIKRDVQHCM 301

                         250
                  ....*....|.
gi 1390086044 358 ALARYLVEEIK 368
Cdd:PLN03032  302 RNAHYLKDRLT 312
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
 98-385 7.01e-07

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 51.09  E-value: 7.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044  98 LVEEAViKKMIEFIGWEEGDGI-FNPGGSVS-NMYAMNLARykfcpEIKEKglsglpRLVLFTSEEcHYSMKKAASFLGI 175
Cdd:pfam00266  44 AYEEAR-EKVAEFINAPSNDEIiFTSGTTEAiNLVALSLGR-----SLKPG------DEIVITEME-HHANLVPWQELAK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 176 -GTENVYFVKTDERGKMIPEELEKQV-QRARkegsapfLVCATAGTTVLGAFDPLDKIADICEKHDLWLHVDASwggSAL 253
Cdd:pfam00266 111 rTGARVRVLPLDEDGLLDLDELEKLItPKTK-------LVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAA---QAI 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 254 ISRKhrrllHGIQR--ADSVAWNPHKML-LAGIQccALLVKDNsgLLKKCysakAAYLFQQDKFYDVSYDTGDKSIQCSR 330
Cdd:pfam00266 181 GHRP-----IDVQKlgVDFLAFSGHKLYgPTGIG--VLYGRRD--LLEKM----PPLLGGGGMIETVSLQESTFADAPWK 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1390086044 331 R----PDAFKFWLMWKA---LGTTGLEERVNRALALARYLVEEIKKREGFQLLLEPEYANVC 385
Cdd:pfam00266 248 FeagtPNIAGIIGLGAAleyLSEIGLEAIEKHEHELAQYLYERLLSLPGIRLYGPERRASII 309
PLN02263 PLN02263
serine decarboxylase
 151-386 1.39e-04

serine decarboxylase


Pssm-ID: 177904 [Multi-domain]  Cd Length: 470  Bit Score: 44.04  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 151 LPRLVLFTSEECHYSMKKAASFLGIGTENvyfVKTDERGKMIPEELEKQVQRARKEgsaPFLVCATAGTTVLGAFDPLDK 230
Cdd:PLN02263  176 FPDGILYASRESHYSVFKAARMYRMECVK---VDTLVSGEIDCADFKAKLLANKDK---PAIINVNIGTTVKGAVDDLDL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 231 IADICEK----HD-LWLHVDASWGGSALISRKHRRLLHGIQRADSVAWNPHKMLLAGIQCCALLVK-DNSGLLKKcysak 304
Cdd:PLN02263  250 VIKTLEEcgfsQDrFYIHCDGALFGLMMPFVKRAPKVTFKKPIGSVSVSGHKFVGCPMPCGVQITRmEHINVLSS----- 324

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 305 aaylfqqdkfyDVSY-DTGDKSIQCSRRPDAFKF-WLMWKALGTTGLEERVNRALALARYLVEEIKKrEGFQLLLEPEYA 382
Cdd:PLN02263  325 -----------NVEYlASRDATIMGSRNGHAPIFlWYTLNRKGYRGFQKEVQKCLRNAHYLKDRLRE-AGISAMLNELSS 392


                  ....
gi 1390086044 383 NVCF 386
Cdd:PLN02263  393 TVVF 396
CsdA COG0520
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
182-279 1.41e-04

Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];


Pssm-ID: 440286 [Multi-domain]  Cd Length: 396  Bit Score: 43.97  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 182 FVKTDERGKMIPEELEKQVQRARKegsapfLVCATAGTTVLGAFDPLDKIADICEKHDLWLHVDA--SWGgsalisrkHR 259
Cdd:COG0520   133 VIPLDEDGELDLEALEALLTPRTK------LVAVTHVSNVTGTVNPVKEIAALAHAHGALVLVDGaqSVP--------HL 198

                          90       100
                  ....*....|....*....|.
gi 1390086044 260 RL-LHGIQrADSVAWNPHKML 279
Cdd:COG0520   199 PVdVQALG-CDFYAFSGHKLY 218
Orn_deC_like cd00615
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 228-294 6.52e-03

Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.


Pssm-ID: 99739 [Multi-domain]  Cd Length: 294  Bit Score: 38.38  E-value: 6.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1390086044 228 LDKIADICEKHDLWLHVDASWGGSALISRKHRR--LLHGiqrADSVAWNPHKMLLAGIQCCALLVKDNS 294
Cdd:cd00615   172 LRKIVEEAHHRGLPVLVDEAHGAHFRFHPILPSsaAMAG---ADIVVQSTHKTLPALTQGSMIHVKGDL 237
PRK06939 PRK06939
2-amino-3-ketobutyrate coenzyme A ligase; Provisional
 194-247 6.77e-03

2-amino-3-ketobutyrate coenzyme A ligase; Provisional


Pssm-ID: 235893 [Multi-domain]  Cd Length: 397  Bit Score: 38.64  E-value: 6.77e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1390086044 194 EELEKQVQRARKEGsAPFLVCATAGttVL---GAFDPLDKIADICEKHDLWLHVDAS 247
Cdd:PRK06939  159 ADLEAQLKEAKEAG-ARHKLIATDG--VFsmdGDIAPLPEICDLADKYDALVMVDDS 212
Beta_elim_lyase pfam01212
Beta-eliminating lyase;
183-246 7.42e-03

Beta-eliminating lyase;


Pssm-ID: 426128 [Multi-domain]  Cd Length: 288  Bit Score: 38.35  E-value: 7.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390086044 183 VKTDERGKMIPEELEKQVQRARKEGSAPF-LVCAT-----AGTTVLgAFDPLDKIADICEKHDLWLHVDA 246
Cdd:pfam01212 101 LDGDEAGNMDLEDLEAAIREVGADIFPPTgLISLEnthnsAGGQVV-SLENLREIAALAREHGIPVHLDG 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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