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Conserved domains on  [gi|139001466|dbj|BAF51667|]
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tolloid-like 2 [Eulemur macaco]

Protein Classification

ZnMc_BMP1_TLD and CUB domain-containing protein( domain architecture ID 10858003)

protein containing domains ZnMc_BMP1_TLD, CUB, EGF_CA, and FXa_inhibition

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_BMP1_TLD cd04281
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) ...
 152-351 2.36e-152

Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, and proteins involved in the mineralization of the extracellular matrix. The drosophila protein tolloid and its Xenopus homologue xolloid cleave and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product) and its homologue BMP4, involved in dorso-ventral patterning.


:

Pssm-ID: 239808 [Multi-domain]  Cd Length: 200  Bit Score: 449.20  E-value: 2.36e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  152 ATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAIS 231
Cdd:cd04281     1 AATARKERIWPGGVIPYVIDGNFTGSQRAMFKQAMRHWENFTCVTFVERTPEENYIVFTYRPCGCCSYVGRRGNGPQAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  232 IGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRG 311
Cdd:cd04281    81 IGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRENIQPGQEYNFLKMEPEEVDSLGEPYDFDSIMHYARNTFSRG 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 139001466  312 VFLDTILPRRDDNGVRPTIGQRVRLSQGDIAQARKLYKCP 351
Cdd:cd04281   161 MFLDTILPKRDPNGVRPEIGQRTRLSEGDIIQANKLYKCP 200
CUB pfam00431
CUB domain;
466-575 7.76e-52

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 177.10  E-value: 7.76e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   466 CGGDINKDAGQIQSPNYPDDYRPSKECVWRISVSEGFHVGLTFQAFEIERHDSCAYDYLEIRDGLTEESALIGHFCGYEK 545
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   546 PEDVKSSSNRLWMKFVSDGSINKAGFAANF 575
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
622-731 4.60e-48

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 166.32  E-value: 4.60e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   622 CGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDASLHGRFCGSET 701
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   702 PEVITSQSNNMRVEFKSDNTVSKRGFRAHF 731
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
353-462 2.33e-42

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 150.14  E-value: 2.33e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   353 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDNV 432
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   433 PEPLTSTASRLWVEFRSSSNSLGKGFFAVY 462
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
778-887 1.27e-41

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 147.83  E-value: 1.27e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   778 CAHKISSAEGTLVSPNWPDKYPSRRECTWNISSTAGHRVKLAFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKK 857
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   858 PDPTVASGSSLFLKFYSDASVQRKGFQAVH 887
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
891-1004 6.31e-38

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 137.43  E-value: 6.31e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   891 CGGRLKaevqTKELYSHAQFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEAECGYDYMEAFDGYDSSAPRLGRFC 970
Cdd:pfam00431    1 CGGVLT----DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 139001466   971 GSGPLEEIYSAGDSLMIRFHTDDTINKKGFHARY 1004
Cdd:pfam00431   77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 738-773 3.02e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.79  E-value: 3.02e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 139001466   738 CAEDNGGCQHECVNTFGSYLCRCRNGYRLHDNGRDC 773
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 582-618 7.98e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.94  E-value: 7.98e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 139001466   582 CSWpDRGGCEHRCVNTLGSYKCTCDPGYELAADKKTC 618
Cdd:pfam14670    1 CSV-NNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
ZnMc_BMP1_TLD cd04281
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) ...
 152-351 2.36e-152

Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, and proteins involved in the mineralization of the extracellular matrix. The drosophila protein tolloid and its Xenopus homologue xolloid cleave and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product) and its homologue BMP4, involved in dorso-ventral patterning.


Pssm-ID: 239808 [Multi-domain]  Cd Length: 200  Bit Score: 449.20  E-value: 2.36e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  152 ATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAIS 231
Cdd:cd04281     1 AATARKERIWPGGVIPYVIDGNFTGSQRAMFKQAMRHWENFTCVTFVERTPEENYIVFTYRPCGCCSYVGRRGNGPQAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  232 IGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRG 311
Cdd:cd04281    81 IGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRENIQPGQEYNFLKMEPEEVDSLGEPYDFDSIMHYARNTFSRG 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 139001466  312 VFLDTILPRRDDNGVRPTIGQRVRLSQGDIAQARKLYKCP 351
Cdd:cd04281   161 MFLDTILPKRDPNGVRPEIGQRTRLSEGDIIQANKLYKCP 200
Astacin pfam01400
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
 159-352 1.76e-99

Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.


Pssm-ID: 426242 [Multi-domain]  Cd Length: 192  Bit Score: 310.75  E-value: 1.76e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   159 RIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDE-ESFIVFSYRTCGCCSYVGRRGGgPQAISIGKNCD 237
Cdd:pfam01400    1 KKWPNGPIPYVIDGSLTGLARALIRQAMRHWENKTCIRFVERTPApDNNYLFFFKGDGCYSYVGRVGG-RQPVSIGDGCD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   238 KFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTI 317
Cdd:pfam01400   80 KFGIIVHELGHALGFFHEQSRPDRDDYVSINWDNIDPGQEGNFDKYDPSEVDSYGVPYDYGSIMHYGPNAFSKNGSLPTI 159

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 139001466   318 LPRrdDNGVRPTIGQRVRLSQGDIAQARKLYKCPA 352
Cdd:pfam01400  160 VPK--DNDYQATIGQRVKLSFYDIKKINKLYKCPS 192
CUB pfam00431
CUB domain;
466-575 7.76e-52

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 177.10  E-value: 7.76e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   466 CGGDINKDAGQIQSPNYPDDYRPSKECVWRISVSEGFHVGLTFQAFEIERHDSCAYDYLEIRDGLTEESALIGHFCGYEK 545
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   546 PEDVKSSSNRLWMKFVSDGSINKAGFAANF 575
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
622-731 4.60e-48

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 166.32  E-value: 4.60e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   622 CGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDASLHGRFCGSET 701
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   702 PEVITSQSNNMRVEFKSDNTVSKRGFRAHF 731
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 622-733 1.39e-42

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 150.64  E-value: 1.39e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  622 CGGFIT-KLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDASLHGRFCGSE 700
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 139001466  701 TPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFS 733
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
353-462 2.33e-42

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 150.14  E-value: 2.33e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   353 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDNV 432
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   433 PEPLTSTASRLWVEFRSSSNSLGKGFFAVY 462
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
778-887 1.27e-41

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 147.83  E-value: 1.27e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   778 CAHKISSAEGTLVSPNWPDKYPSRRECTWNISSTAGHRVKLAFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKK 857
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   858 PDPTVASGSSLFLKFYSDASVQRKGFQAVH 887
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 631-731 5.70e-41

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 145.61  E-value: 5.70e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    631 GTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDASLHGRFCGSETPE-VITSQS 709
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPpVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 139001466    710 NNMRVEFKSDNTVSKRGFRAHF 731
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 466-576 1.16e-40

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 145.25  E-value: 1.16e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  466 CGGDINKDA-GQIQSPNYPDDYRPSKECVWRISVSEGFHVGLTFQAFEIERHDSCAYDYLEIRDGLTEESALIGHFCGYE 544
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 139001466  545 KPEDVKSSSNRLWMKFVSDGSINKAGFAANFF 576
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 158-299 1.91e-40

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 145.57  E-value: 1.91e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    158 ERIWPGGVIPYVI-GGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEES-FIVFSYRTCGCC-SYVGRRGGGpQAISIGK 234
Cdd:smart00235    2 SKKWPKGTVPYVIdSSSLSPEEREAIAKALAEWSDVTCIRFVERTGTADiYISFGSGDSGCTlSHAGRPGGD-QHLSLGN 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 139001466    235 NCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGqeyNFLKMeagEVSSLGETYDFDS 299
Cdd:smart00235   81 GCINTGVAAHELGHALGLYHEQSRSDRDNYMYINYTNIDTR---NFDLS---EDDSLGIPYDYGS 139
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 475-575 2.07e-40

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 144.07  E-value: 2.07e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    475 GQIQSPNYPDDYRPSKECVWRISVSEGFHVGLTFQAFEIERHDSCAYDYLEIRDGLTEESALIGHFCGYEKPEDVKSS-S 553
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsS 80

                            90       100
                    ....*....|....*....|..
gi 139001466    554 NRLWMKFVSDGSINKAGFAANF 575
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 353-464 2.05e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 138.70  E-value: 2.05e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  353 CGETLQDTT-GNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDN 431
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 139001466  432 VPEPLTSTASRLWVEFRSSSNSLGKGFFAVYEA 464
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
891-1004 6.31e-38

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 137.43  E-value: 6.31e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   891 CGGRLKaevqTKELYSHAQFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEAECGYDYMEAFDGYDSSAPRLGRFC 970
Cdd:pfam00431    1 CGGVLT----DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 139001466   971 GSGPLEEIYSAGDSLMIRFHTDDTINKKGFHARY 1004
Cdd:pfam00431   77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 782-889 6.49e-37

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 134.46  E-value: 6.49e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  782 ISSAEGTLVSPNWPDKYPSRRECTWNISSTAGHRVKLAFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPT 861
Cdd:cd00041     6 TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPI 85

                          90       100
                  ....*....|....*....|....*...
gi 139001466  862 VASGSSLFLKFYSDASVQRKGFQAVHST 889
Cdd:cd00041    86 ISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 787-885 2.62e-36

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 132.51  E-value: 2.62e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    787 GTLVSPNWPDKYPSRRECTWNISSTAGHRVKLAFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVAS-G 865
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsS 80

                            90       100
                    ....*....|....*....|
gi 139001466    866 SSLFLKFYSDASVQRKGFQA 885
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSA 100
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 362-462 3.70e-35

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 129.05  E-value: 3.70e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    362 GNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDNVPEPLTSTAS 441
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 139001466    442 -RLWVEFRSSSNSLGKGFFAVY 462
Cdd:smart00042   81 nSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 891-1006 1.18e-32

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 122.52  E-value: 1.18e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  891 CGGRLKAEvQTKELYSHaqFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEAECGYDYMEAFDGYDSSAPRLGRFC 970
Cdd:cd00041     1 CGGTLTAS-TSGTISSP--NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 139001466  971 GSGPLEEIYSAGDSLMIRFHTDDTINKKGFHARYTS 1006
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 913-1004 1.90e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 112.87  E-value: 1.90e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    913 NNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEAECGYDYMEAFDGYDSSAPRLGRFCGSGPLEE-IYSAGDSLMIRFHT 991
Cdd:smart00042   10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNSLTLTFVS 89

                            90
                    ....*....|...
gi 139001466    992 DDTINKKGFHARY 1004
Cdd:smart00042   90 DSSVQKRGFSARY 102
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 738-773 3.02e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.79  E-value: 3.02e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 139001466   738 CAEDNGGCQHECVNTFGSYLCRCRNGYRLHDNGRDC 773
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 582-618 7.98e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.94  E-value: 7.98e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 139001466   582 CSWpDRGGCEHRCVNTLGSYKCTCDPGYELAADKKTC 618
Cdd:pfam14670    1 CSV-NNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
578-619 1.01e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.01e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 139001466    578 EVDECSwpDRGGCEH--RCVNTLGSYKCTCDPGYElaaDKKTCE 619
Cdd:smart00179    1 DIDECA--SGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
734-774 4.86e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 4.86e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 139001466    734 DKDECAEDNGgCQH--ECVNTFGSYLCRCRNGYRlhdNGRDCK 774
Cdd:smart00179    1 DIDECASGNP-CQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 579-619 8.89e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 8.89e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 139001466  579 VDECSWPDRGGCEHRCVNTLGSYKCTCDPGYELaadkKTCE 619
Cdd:cd00054     2 IDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG----RNCE 38
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 716-771 4.26e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 48.92  E-value: 4.26e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 139001466  716 FKSDNTVSKRgFRAHFFSDKDECAEDNGGCQHECVNTFGSYLCRCRNGYRLHDNGR 771
Cdd:cd01475   169 FSTIEELTKK-FQGKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
 
Name Accession Description Interval E-value
ZnMc_BMP1_TLD cd04281
Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) ...
 152-351 2.36e-152

Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, and proteins involved in the mineralization of the extracellular matrix. The drosophila protein tolloid and its Xenopus homologue xolloid cleave and inactivate Sog and chordin, respectively, which are inhibitors of Dpp (the Drosophila decapentaplegic gene product) and its homologue BMP4, involved in dorso-ventral patterning.


Pssm-ID: 239808 [Multi-domain]  Cd Length: 200  Bit Score: 449.20  E-value: 2.36e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  152 ATTSRTERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGCCSYVGRRGGGPQAIS 231
Cdd:cd04281     1 AATARKERIWPGGVIPYVIDGNFTGSQRAMFKQAMRHWENFTCVTFVERTPEENYIVFTYRPCGCCSYVGRRGNGPQAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  232 IGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRG 311
Cdd:cd04281    81 IGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVTIIRENIQPGQEYNFLKMEPEEVDSLGEPYDFDSIMHYARNTFSRG 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 139001466  312 VFLDTILPRRDDNGVRPTIGQRVRLSQGDIAQARKLYKCP 351
Cdd:cd04281   161 MFLDTILPKRDPNGVRPEIGQRTRLSEGDIIQANKLYKCP 200
Astacin pfam01400
Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. ...
 159-352 1.76e-99

Astacin (Peptidase family M12A); The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis such as Swiss:P13497, and Tolloid from drosophila.


Pssm-ID: 426242 [Multi-domain]  Cd Length: 192  Bit Score: 310.75  E-value: 1.76e-99
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   159 RIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDE-ESFIVFSYRTCGCCSYVGRRGGgPQAISIGKNCD 237
Cdd:pfam01400    1 KKWPNGPIPYVIDGSLTGLARALIRQAMRHWENKTCIRFVERTPApDNNYLFFFKGDGCYSYVGRVGG-RQPVSIGDGCD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   238 KFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTI 317
Cdd:pfam01400   80 KFGIIVHELGHALGFFHEQSRPDRDDYVSINWDNIDPGQEGNFDKYDPSEVDSYGVPYDYGSIMHYGPNAFSKNGSLPTI 159

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 139001466   318 LPRrdDNGVRPTIGQRVRLSQGDIAQARKLYKCPA 352
Cdd:pfam01400  160 VPK--DNDYQATIGQRVKLSFYDIKKINKLYKCPS 192
ZnMc_astacin_like cd04280
Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of ...
 163-348 3.29e-78

Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to yield the active protease domain, which is consequently always found at the N-terminus in multi-domain architectures. This family includes: astacin, a digestive enzyme from Crayfish; meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain, proteins involved in (bone) morphogenesis, tolloid from drosophila, and the sea urchin SPAN protein, which may also play a role in development.


Pssm-ID: 239807 [Multi-domain]  Cd Length: 180  Bit Score: 253.26  E-value: 3.29e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  163 GGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTcGCCSYVGRRGGgPQAISIGKNCDKFGIV 242
Cdd:cd04280     1 NGTVPYVIDGSFDESDRSLILRAMREIESNTCIRFVPRTTEKDYIRIVKGS-GCWSYVGRVGG-RQVVSLGSGCFSLGTI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  243 AHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVfLDTILPRrd 322
Cdd:cd04280    79 VHELMHALGFYHEQSRPDRDDYVTINWENIQPGYEHNFDKYSPDTVTTYGVPYDYGSVMHYGPTAFSKNG-KPTIVPK-- 155

                         170       180
                  ....*....|....*....|....*.
gi 139001466  323 DNGVrPTIGQRVRLSQGDIAQARKLY 348
Cdd:cd04280   156 DPGY-QIIGQREGLSFLDIKKINKMY 180
ZnMc_hatching_enzyme cd04283
Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted ...
 166-350 3.77e-60

Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted by teleost embryos to digest the egg envelope or chorion. In some teleosts, the hatching enzyme may be a system consisting of two evolutionary related metalloproteases, high choriolytic enzyme and low choriolytic enzyme (HCE and LCE), which may have different substrate specificities and cooperatively digest the chorion.


Pssm-ID: 239810 [Multi-domain]  Cd Length: 182  Bit Score: 203.26  E-value: 3.77e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  166 IPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTcGCCSYVGRRGGGpQAISIGKN-CDKFGIVAH 244
Cdd:cd04283     6 VPYVISPQYSENERAVIEKAMQEFETLTCVRFVPRTTERDYLNIESRS-GCWSYIGRQGGR-QTVSLQKQgCMYKGIIQH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  245 ELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAgevSSLGETYDFDSIMHYARNTFSRGvFLDTILPRRDDN 324
Cdd:cd04283    84 ELLHALGFYHEQTRSDRDKYVRINWENIIPDQLYNFDKQDT---NNLGTPYDYSSVMHYGRYAFSIN-GKPTIVPIPDPN 159

                         170       180
                  ....*....|....*....|....*.
gi 139001466  325 gvrPTIGQRVRLSQGDIAQARKLYKC 350
Cdd:cd04283   160 ---VPIGQRQGMSNLDILRINKLYNC 182
CUB pfam00431
CUB domain;
466-575 7.76e-52

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 177.10  E-value: 7.76e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   466 CGGDINKDAGQIQSPNYPDDYRPSKECVWRISVSEGFHVGLTFQAFEIERHDSCAYDYLEIRDGLTEESALIGHFCGYEK 545
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   546 PEDVKSSSNRLWMKFVSDGSINKAGFAANF 575
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
622-731 4.60e-48

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 166.32  E-value: 4.60e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   622 CGGFITKLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDASLHGRFCGSET 701
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   702 PEVITSQSNNMRVEFKSDNTVSKRGFRAHF 731
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 622-733 1.39e-42

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 150.64  E-value: 1.39e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  622 CGGFIT-KLNGTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDASLHGRFCGSE 700
Cdd:cd00041     1 CGGTLTaSTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 139001466  701 TPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFS 733
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
353-462 2.33e-42

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 150.14  E-value: 2.33e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   353 CGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDNV 432
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   433 PEPLTSTASRLWVEFRSSSNSLGKGFFAVY 462
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB pfam00431
CUB domain;
778-887 1.27e-41

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 147.83  E-value: 1.27e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   778 CAHKISSAEGTLVSPNWPDKYPSRRECTWNISSTAGHRVKLAFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKK 857
Cdd:pfam00431    1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFCGSGI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 139001466   858 PDPTVASGSSLFLKFYSDASVQRKGFQAVH 887
Cdd:pfam00431   81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 631-731 5.70e-41

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 145.61  E-value: 5.70e-41
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    631 GTITSPGWPKEYPTNKNCVWQVVAPVQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDASLHGRFCGSETPE-VITSQS 709
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPpVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 139001466    710 NNMRVEFKSDNTVSKRGFRAHF 731
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 466-576 1.16e-40

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 145.25  E-value: 1.16e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  466 CGGDINKDA-GQIQSPNYPDDYRPSKECVWRISVSEGFHVGLTFQAFEIERHDSCAYDYLEIRDGLTEESALIGHFCGYE 544
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 139001466  545 KPEDVKSSSNRLWMKFVSDGSINKAGFAANFF 576
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYS 112
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
 158-299 1.91e-40

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 145.57  E-value: 1.91e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    158 ERIWPGGVIPYVI-GGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEES-FIVFSYRTCGCC-SYVGRRGGGpQAISIGK 234
Cdd:smart00235    2 SKKWPKGTVPYVIdSSSLSPEEREAIAKALAEWSDVTCIRFVERTGTADiYISFGSGDSGCTlSHAGRPGGD-QHLSLGN 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 139001466    235 NCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGqeyNFLKMeagEVSSLGETYDFDS 299
Cdd:smart00235   81 GCINTGVAAHELGHALGLYHEQSRSDRDNYMYINYTNIDTR---NFDLS---EDDSLGIPYDYGS 139
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 475-575 2.07e-40

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 144.07  E-value: 2.07e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    475 GQIQSPNYPDDYRPSKECVWRISVSEGFHVGLTFQAFEIERHDSCAYDYLEIRDGLTEESALIGHFCGYEKPEDVKSS-S 553
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsS 80

                            90       100
                    ....*....|....*....|..
gi 139001466    554 NRLWMKFVSDGSINKAGFAANF 575
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 353-464 2.05e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 138.70  E-value: 2.05e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  353 CGETLQDTT-GNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDN 431
Cdd:cd00041     1 CGGTLTASTsGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGST 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 139001466  432 VPEPLTSTASRLWVEFRSSSNSLGKGFFAVYEA 464
Cdd:cd00041    81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
891-1004 6.31e-38

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 137.43  E-value: 6.31e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466   891 CGGRLKaevqTKELYSHAQFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEAECGYDYMEAFDGYDSSAPRLGRFC 970
Cdd:pfam00431    1 CGGVLT----DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLGRFC 76

                           90       100       110
                   ....*....|....*....|....*....|....
gi 139001466   971 GSGPLEEIYSAGDSLMIRFHTDDTINKKGFHARY 1004
Cdd:pfam00431   77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 782-889 6.49e-37

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 134.46  E-value: 6.49e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  782 ISSAEGTLVSPNWPDKYPSRRECTWNISSTAGHRVKLAFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPT 861
Cdd:cd00041     6 TASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFCGSTLPPPI 85

                          90       100
                  ....*....|....*....|....*...
gi 139001466  862 VASGSSLFLKFYSDASVQRKGFQAVHST 889
Cdd:cd00041    86 ISSGNSLTVRFRSDSSVTGRGFKATYSA 113
ZnMc_meprin cd04282
Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted ...
 161-350 8.98e-37

Zinc-dependent metalloprotease, meprin_like subfamily. Meprins are membrane-bound or secreted extracellular proteases, which cleave a variety of targets, including peptides such as parathyroid hormone, gastrin, and cholecystokinin, cytokines such as osteopontin, and proteins such as collagen IV, fibronectin, casein and gelatin. Meprins may also be able to release proteins from the cell surface. Closely related meprin alpha- and beta-subunits form homo- and hetero-oligomers; these complexes are found on epithelial cells of the intestine, for example, and are also expressed in certain cancer cells.


Pssm-ID: 239809 [Multi-domain]  Cd Length: 230  Bit Score: 138.37  E-value: 8.98e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  161 WPGgVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFsYRTCGCCSYVGRRGGGpQAISIGKNCDKFG 240
Cdd:cd04282    46 WPF-PIPYILDDSLDLNAKGVILKAFEMYRLKSCVDFKPYEGESNYIFF-FKGSGCWSMVGDQQGG-QNLSIGAGCDYKA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  241 IVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQEYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPR 320
Cdd:cd04282   123 TVEHEFLHALGFYHEQSRSDRDDYVKIWWDQILSGREHNFNKYDDSFSTDLNTPYDYESVMHYSPFSFNKGASEPTITTK 202

                         170       180       190
                  ....*....|....*....|....*....|.
gi 139001466  321 RDD-NGVrptIGQRVRLSQGDIAQARKLYKC 350
Cdd:cd04282   203 IPEfNDI---IGQRLDFSDIDLERLNRMYNC 230
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 787-885 2.62e-36

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 132.51  E-value: 2.62e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    787 GTLVSPNWPDKYPSRRECTWNISSTAGHRVKLAFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVAS-G 865
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSsS 80

                            90       100
                    ....*....|....*....|
gi 139001466    866 SSLFLKFYSDASVQRKGFQA 885
Cdd:smart00042   81 NSLTLTFVSDSSVQKRGFSA 100
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 362-462 3.70e-35

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 129.05  E-value: 3.70e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    362 GNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDNVPEPLTSTAS 441
Cdd:smart00042    1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                            90       100
                    ....*....|....*....|..
gi 139001466    442 -RLWVEFRSSSNSLGKGFFAVY 462
Cdd:smart00042   81 nSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 891-1006 1.18e-32

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 122.52  E-value: 1.18e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  891 CGGRLKAEvQTKELYSHaqFGDNNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEAECGYDYMEAFDGYDSSAPRLGRFC 970
Cdd:cd00041     1 CGGTLTAS-TSGTISSP--NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPLLGRFC 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 139001466  971 GSGPLEEIYSAGDSLMIRFHTDDTINKKGFHARYTS 1006
Cdd:cd00041    78 GSTLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 913-1004 1.90e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 112.87  E-value: 1.90e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466    913 NNYPSQARCDWVIVAEDGYGVELIFRTFEVEEEAECGYDYMEAFDGYDSSAPRLGRFCGSGPLEE-IYSAGDSLMIRFHT 991
Cdd:smart00042   10 QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSASSPLLGRFCGSEAPPPvISSSSNSLTLTFVS 89

                            90
                    ....*....|...
gi 139001466    992 DDTINKKGFHARY 1004
Cdd:smart00042   90 DSSVQKRGFSARY 102
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 164-348 5.97e-24

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 99.52  E-value: 5.97e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  164 GVIPYVIGG--------NFTGSQRAIFKQAMRHWEKHTCVTFIERTDEES---FIVFSYRT-----CGCCSYVGR-RGGG 226
Cdd:cd00203     1 KVIPYVVVAddrdveeeNLSAQIQSLILIAMQIWRDYLNIRFVLVGVEIDkadIAILVTRQdfdggTGGWAYLGRvCDSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  227 PQAISIGKNC----DKFGIVAHELGHVVGFWHEHTRPDRDQHVTIireniqpgqeynflkmeagEVSSLGETYDFDSIMH 302
Cdd:cd00203    81 RGVGVLQDNQsgtkEGAQTIAHELGHALGFYHDHDRKDRDDYPTI-------------------DDTLNAEDDDYYSVMS 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 139001466  303 YARNTFSrgvfldtilprrddngvrptIGQRVRLSQGDIAQARKLY 348
Cdd:cd00203   142 YTKGSFS--------------------DGQRKDFSQCDIDQINKLY 167
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
 164-348 1.18e-19

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 87.17  E-value: 1.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  164 GVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEES--FIVFSYR----TCGCCSYVGRRGGGPQA-ISIGKNC 236
Cdd:cd04268     2 KPITYYIDDSVPDKLRAAILDAIEAWNKAFAIGFKNANDVDPadIRYSVIRwipyNDGTWSYGPSQVDPLTGeILLARVY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  237 D-----------KFGIVAHELGHVVGFWHEHTRPDRDQHVTIireniqpgqeynflkmeagevssLGETYDFDSIMHYAR 305
Cdd:cd04268    82 LyssfveysgarLRNTAEHELGHALGLRHNFAASDRDDNVDL-----------------------LAEKGDTSSVMDYAP 138

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 139001466  306 NTFSrgvfldtilprrddngVRPTIGQRVRLSQGDIAQARKLY 348
Cdd:cd04268   139 SNFS----------------IQLGDGQKYTIGPYDIAAIKKLY 165
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 738-773 3.02e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 58.79  E-value: 3.02e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 139001466   738 CAEDNGGCQHECVNTFGSYLCRCRNGYRLHDNGRDC 773
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 582-618 7.98e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.94  E-value: 7.98e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 139001466   582 CSWpDRGGCEHRCVNTLGSYKCTCDPGYELAADKKTC 618
Cdd:pfam14670    1 CSV-NNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
ZnMc_MMP_like_3 cd04327
Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal ...
 161-348 4.16e-09

Zinc-dependent metalloprotease; MMP_like sub-family 3. A group of bacterial and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239819 [Multi-domain]  Cd Length: 198  Bit Score: 57.39  E-value: 4.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  161 W-PGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTC-GCCSYVGRrgggpQAISIGK---- 234
Cdd:cd04327     3 WrNGTVLRIAFLGGPDAFLKDKVRAAAREWLPYANLKFKFVTDADADIRISFTPGdGYWSYVGT-----DALLIGAdapt 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  235 -NCDKFG----------IVAHELGHVVGFWHEHTRPD-----RDQHV-------------TIIRENIqpgqeynFLKMEA 285
Cdd:cd04327    78 mNLGWFTddtpdpefsrVVLHEFGHALGFIHEHQSPAanipwDKEAVyayfsgppnwdreTVINHNV-------FAKLDD 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 139001466  286 GEVSslGETYDFDSIMHYArntFSRGVFLDTilprrddngvRPTIGQRVrLSQGDIAQARKLY 348
Cdd:cd04327   151 GDVA--YSPYDPDSIMHYP---FPGSLTLDG----------EEVPPNRT-LSDKDKAFMRLLY 197
EGF_CA smart00179
Calcium-binding EGF-like domain;
578-619 1.01e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.78  E-value: 1.01e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 139001466    578 EVDECSwpDRGGCEH--RCVNTLGSYKCTCDPGYElaaDKKTCE 619
Cdd:smart00179    1 DIDECA--SGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
734-774 4.86e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 4.86e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 139001466    734 DKDECAEDNGgCQH--ECVNTFGSYLCRCRNGYRlhdNGRDCK 774
Cdd:smart00179    1 DIDECASGNP-CQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 579-619 8.89e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 8.89e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 139001466  579 VDECSWPDRGGCEHRCVNTLGSYKCTCDPGYELaadkKTCE 619
Cdd:cd00054     2 IDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG----RNCE 38
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 716-771 4.26e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 48.92  E-value: 4.26e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 139001466  716 FKSDNTVSKRgFRAHFFSDKDECAEDNGGCQHECVNTFGSYLCRCRNGYRLHDNGR 771
Cdd:cd01475   169 FSTIEELTKK-FQGKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 734-774 5.67e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 5.67e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 139001466  734 DKDECAEDNGgCQH--ECVNTFGSYLCRCRNGYRlhdnGRDCK 774
Cdd:cd00054     1 DIDECASGNP-CQNggTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF smart00181
Epidermal growth factor-like domain;
581-619 1.63e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 39.81  E-value: 1.63e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 139001466    581 ECSwpDRGGCEH-RCVNTLGSYKCTCDPGYELAadkKTCE 619
Cdd:smart00181    1 ECA--SGGPCSNgTCINTPGSYTCSCPPGYTGD---KRCE 35
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 581-619 1.74e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.77  E-value: 1.74e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 139001466  581 ECSwpDRGGCEH--RCVNTLGSYKCTCDPGYELaadKKTCE 619
Cdd:cd00053     1 ECA--ASNPCSNggTCVNTPGSYRCVCPPGYTG---DRSCE 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 571-617 2.48e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.53  E-value: 2.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 139001466  571 FAANFFKEVDECSWPDRGgCEHRCVNTLGSYKCTCDPGYELAADKKT 617
Cdd:cd01475   179 FQGKICVVPDLCATLSHV-CQQVCISTPGSYLCACTEGYALLEDNKT 224
ZnMc_MMP_like_1 cd04279
Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and ...
 166-260 3.37e-04

Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin.


Pssm-ID: 239806 [Multi-domain]  Cd Length: 156  Bit Score: 42.06  E-value: 3.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139001466  166 IPYVIGGNFTGSQR-------AIfKQAMRHWEKHTCVTFIERTDEES---FIVFSYRTCGCCSYVGRRGGGPQAISIGKN 235
Cdd:cd04279     4 IRVYIDPTPAPPDSraqswlqAV-KQAAAEWENVGPLKFVYNPEEDNdadIVIFFDRPPPVGGAGGGLARAGFPLISDGN 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 139001466  236 CDKF-------------------GIVAHELGHVVGFWHEHTRPD 260
Cdd:cd04279    83 RKLFnrtdinlgpgqprgaenlqAIALHELGHALGLWHHSDRPE 126
EGF smart00181
Epidermal growth factor-like domain;
737-769 6.14e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.27  E-value: 6.14e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 139001466    737 ECAEdNGGCQH-ECVNTFGSYLCRCRNGYRLHDN 769
Cdd:smart00181    1 ECAS-GGPCSNgTCINTPGSYTCSCPPGYTGDKR 33
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 737-769 1.39e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 1.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 139001466  737 ECAEDNGgCQH--ECVNTFGSYLCRCRNGYRLHDN 769
Cdd:cd00053     1 ECAASNP-CSNggTCVNTPGSYRCVCPPGYTGDRS 34
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 588-618 3.26e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.04  E-value: 3.26e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 139001466   588 GGC-EH-RCVNTLGSYKCTCDPGYELaaDKKTC 618
Cdd:pfam12947    6 GGChPNaTCTNTGGSFTCTCNDGYTG--DGVTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
579-608 4.42e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.68  E-value: 4.42e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 139001466   579 VDECSWP----DRGGcehRCVNTLGSYKCTCDPG 608
Cdd:pfam07645    2 VDECATGthncPANT---VCVNTIGSFECRCPDG 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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