|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
25-428 |
1.29e-86 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 268.67 E-value: 1.29e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 25 WRILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVV 104
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 105 SMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLIlmldgwLGLRG 184
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL------LLLFG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 185 WHLLFIIEGLPAVLLGIAAFFILrdrphqaawlndrqktwlentlqaerqqqkqightttwqllkhRQIWLMALIYAGAS 264
Cdd:cd17319 156 WRWAFIIEGLLGLLLAVLWWFYL-------------------------------------------RQVWGLALGYFGIN 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 265 SAGTTLSVWSPQLLKS-FHLDNLTTGLLNAIPYGLASVLMIVWGRSSDR--NNERRWHTALTLFMIAAGVFAAFINLSLP 341
Cdd:cd17319 193 YALYGLLTWLPTYLKQaRGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRllRGARRLVIIIGLLLAAVGLLLAYLTTSPV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 342 ATIMILSTILIGAYAAKGPFWALASGWMSSTSAAAGLAAIGAIANLiGGAVMVNAYGIISERTGSHTLAMLPLAALCLAG 421
Cdd:cd17319 273 VAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNL-GGFVAPLLIGYLVDATGSYTAAFLFLAAVALLA 351
|
....*..
gi 1388639982 422 GIAVLAM 428
Cdd:cd17319 352 ALLVLLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
35-426 |
1.83e-74 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 238.78 E-value: 1.83e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 35 YLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMALVQNT 114
Cdd:TIGR00893 3 TVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 115 TSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMldgwlgLRGWHLLFIIEGL 194
Cdd:TIGR00893 83 VSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILI------HFSWQWAFIIEGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 195 PAVLLGIAAFFILRDRPHQAAWLNDRQKTWLENTLQAErQQQKQIGHTTT---WQLLKHRQIWLMALIYAGASSAGTTLS 271
Cdd:TIGR00893 157 LGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAE-QQGKGPSTPKKyqiKELLKDRRVWGLALGQFLVNIGLGFFL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 272 VWSPQLLKSFH-LDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNERRWH------TALTLFMIAAGVFAAFINLSLPATI 344
Cdd:TIGR00893 236 TWFPTYLVQERgLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSlvfarkTAIIAGLVLSLLMFATNYVNIPYAA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 345 MILSTILIGAYAAKGPFWALasgwMSSTSAAAGLAAIGAIANLIGGA---VMVNAYGIISERTGSHTLAMLPLAALCLAG 421
Cdd:TIGR00893 316 LALVALGFFGLGAGAIGWAL----ISDNAPGNIAGLTGGLINSLGNLggiVGPIVIGAIAATTGSFAGALMVVAALALIG 391
|
....*
gi 1388639982 422 GIAVL 426
Cdd:TIGR00893 392 ALSYL 396
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
25-371 |
4.39e-54 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 185.53 E-value: 4.39e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 25 WRILPFLVVSYLVSIIDRGNIGMAALQ-MNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGV 103
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 104 VSMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLDGWLGLR 183
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 184 GWHLLFIIEGLPAVLLGIAAFFILRDRPHQAAWLNDRQKTWLENTLQAErqQQKQIGHTTTWQL----LKHRQIWLMALI 259
Cdd:cd17327 164 GWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRAN--QTGKGDQKFKWKQikeaFKDPRTWLLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 260 YAGASSAGTTLSVWSPQLLKSFHLDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNERRWHTALTLFMIAAGvFAAFINLS 339
Cdd:cd17327 242 FFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVG-SIILLAAP 320
|
330 340 350
....*....|....*....|....*....|...
gi 1388639982 340 LPATI-MILSTILIGAYAAKGPFWALASGWMSS 371
Cdd:cd17327 321 NPPGAyFAAYILGGGSYAGFPILLSWISSNCAG 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-431 |
8.30e-53 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 180.84 E-value: 8.30e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 17 KETMRRVIWRILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPR 96
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 97 IMISWGVVSMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILML 176
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 177 DgwlglrGWHLLFIIEGLPAVLLGIAAFfilrdrphqaawlndrqktwlentlqaerqqqkqightttwqllkhrqiWLM 256
Cdd:COG2271 161 F------GWRAAFLILGLPGLLLALLRF-------------------------------------------------WLL 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 257 ALIYAGASSAGTTLSVWSPQLLKS-FHLDNLTTGLLNAIPYGLASVLMIVWGRSSDR-NNERRWHTALTLFMIAAGVFAA 334
Cdd:COG2271 186 ALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlGRRRKLVLAIGLLLAALALLLL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 335 FINLSLPATIMILSTILIGAYAAKGPFWALASGwMSSTSAAAGLAAIGAIANLIGGAVMVNAYGIISERTGsHTLAMLPL 414
Cdd:COG2271 266 ALLPSPALAIALLFLAGFGLGGAFGLLWALAAE-LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLL 343
|
410
....*....|....*..
gi 1388639982 415 AALCLAGGIAVLAMGRR 431
Cdd:COG2271 344 AALALLAALLALLLLRE 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
25-436 |
5.19e-47 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 166.21 E-value: 5.19e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 25 WRILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVV 104
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 105 SMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLIlmldgwLGLRG 184
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL------IAAFG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 185 WHLLFIIEGLPAVLLGIAAFFILRDRPhqaawlndrqktwlentlqAERQQQKQIGHTTTWQLLKHRQIWLMALIYAGAS 264
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPP-------------------AGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 265 SAGTTLSVWSPQLLKS-FHLDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNERRWHTALTLFMIAAGVFAAFINLSLPAT 343
Cdd:COG2223 219 GSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 344 IMILSTILIGAYAAKGPFWALASGWMSSTSAAAGLAAIGAIANLiGGAVMVNAYGIISERTGSHTLAMLPLAALCLAGGI 423
Cdd:COG2223 299 LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL-GGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
410
....*....|...
gi 1388639982 424 AVLAMGRRYSQTA 436
Cdd:COG2223 378 LTLLLYRRPRRAA 390
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
31-354 |
6.91e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 110.59 E-value: 6.91e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 31 LVVSYLVSIIDRGNIGMA-ALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMA 109
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 110 LVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLIlmldgwLGLRGWHLLF 189
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL------ASLFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 190 IIEGLPAVLLGIAAFFILRDRPHQAawlndrqktwlentlqAERQQQKQIGHTTTWQLLKHRQIWLMALIYAGASSAGTT 269
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKR----------------PKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 270 LSVWSPQLLKSFHLDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNERRWHTALTLFMIAAGVFAAFINLSLPATIMILST 349
Cdd:pfam07690 219 LLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLAL 298
|
....*
gi 1388639982 350 ILIGA 354
Cdd:pfam07690 299 LLLGF 303
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
31-426 |
4.92e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 102.89 E-value: 4.92e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 31 LVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMAL 110
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 111 VQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLDGWlglrGWHLLFI 190
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----GWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 191 IEGLPAVLLGIAAFFILRDRPHQAAWLNDRQKTWLENTLqaerqqqkqighttTWQLLKHRQIWLMALIYAGASSAGTTL 270
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL--------------LKRVLKNPGLWLLLLAIFLVNLAYYSF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 271 SVWSPQLLKSFHLDNLTTGLLNAIPYGLASVL-MIVWGRSSDRNNERRWHTALTLFMIAAGVFAAFINLSLPATIMILST 349
Cdd:cd06174 223 STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALgSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388639982 350 ILIGAYAAKGPFWALASGwMSSTSAAAGLAAIGAIANLIGGAVMVNAYGIISERTGSHTLAMLPLAALCLAGGIAVL 426
Cdd:cd06174 303 LGFGLGGLLPLSFALIAE-LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-354 |
5.63e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 99.28 E-value: 5.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 19 TMRRVIWRILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIM 98
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 99 ISWGVVSMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLIlmldg 178
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL----- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 179 wLGLRGWHLLFIIEGLPAVLLGIAAFFILRDRPHQAawlndrqktwlentlqaerqqqKQIGHTTTWQLLKHRQIWLMAL 258
Cdd:COG2814 158 -ADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAA----------------------RARLRGSLRELLRRPRLLLLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 259 IYAGASSAGTTLSVWSPQLLKS-FHLDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNERRwhtALTLFMIAAGVFAAFIN 337
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR---LLLIGLLLLALGLLLLA 291
|
330
....*....|....*..
gi 1388639982 338 LSLPATIMILSTILIGA 354
Cdd:COG2814 292 LAGSLWLLLLALFLLGF 308
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
35-367 |
5.69e-19 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 88.20 E-value: 5.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 35 YLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMALVQNT 114
Cdd:TIGR00881 4 YAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 115 TSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLdgwlgLRGWHLLFIIEGL 194
Cdd:TIGR00881 84 WVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAE-----LYSWHWVFIVPGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 195 PAVLLGIAAFFILRDRPHQAA------WLNDRQKTWLENtlQAERQQQKQIGhttTWQLLKHRQIWLMALIYAGASSAGT 268
Cdd:TIGR00881 159 IAIIVSLICFLLLRDSPQSCGlppaeeMPNEEPDGDAEK--KEEELTKKQIF---LQYVLLNKVLWYISLGYVFVYVVRT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 269 TLSVWSPQ-LLKSFHLDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNERRWHT----ALTLFMIAAGVFAAFINLSLPAT 343
Cdd:TIGR00881 234 GILDWSPLyLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPlavfFMALIIVSLLVYWLNPAANPLMD 313
|
330 340
....*....|....*....|....
gi 1388639982 344 IMILSTILIGAYAAKGPFWALASG 367
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLIGVIASE 337
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
54-354 |
9.74e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.47 E-value: 9.74e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 54 EDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMALVQNTTSLYIVRFLLGAAEAGFFP 133
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 134 GVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLIlmldgwLGLRGWHLLFIIEGLPAVLLGIAAFFILRDRPHQ 213
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLL------ADALGYRAPFLVCAALALLALVLALLLLPEPRPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 214 aawlndrqktwlentlQAERQQQKQIGHTTTWQLLKHRQIWLMALIYAGASSA-GTTLSVWSPQLLKSFHLDNLTTGLLN 292
Cdd:cd17325 178 ----------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAfGALEPFLPLYAAELGGLSPAQIGLLF 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1388639982 293 AIPYGLASVLMIVWGRSSDRNNERRWhtaLTLFMIAAGVFAAFINLSLPATIMILSTILIGA 354
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPL---ILIGLLLSAVALLLLPLATSFWLLLLLLALLGL 300
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
54-432 |
5.92e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 79.15 E-value: 5.92e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 54 EDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGarlwiPRIMISWGVVSMC-----MALVQNTTSLYIVRFLLGAAE 128
Cdd:COG2807 46 ADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG-----LERTLLLALLLLAaglllRSLAPSVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 129 AGFFPGVVLYLTWWIPSRyRARIIASFMVAIPLANFIGSPLSGLILmldgwlGLRGWHLLFIIEGLPAVLLGIAAFFILR 208
Cdd:COG2807 121 AVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLA------AALGWRGALAVWALLALLALLLWLPLLR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 209 DRPHQAAwlndrqktwlentlqaerqqqKQIGHTTTWQLLKHRQIWLMALIYAGASSAGTTLSVWSPQLLKSFHLDNLTT 288
Cdd:COG2807 194 RRPAAAA---------------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 289 GLLNAIpYGLASVLM-IVWGRSSDRNNERRWHTALTLFMIAAG-------------VFAAFINLSLPATImILSTILIGA 354
Cdd:COG2807 253 GLLLSL-FQLAGIPGsLLVPLLADRLGDRRPLLLLLGLLGLAGllglllapgslpwLWAVLLGLGQGGLF-PLALTLIGL 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1388639982 355 YAAKGPFWALASGWMSSTSAaaglaaigaianlIGGAVMVNAYGIISERTGSHTLAMLPLAALCLAGGIAVLAMGRRY 432
Cdd:COG2807 331 RARTPAEAAALSGMAQSVGY-------------LLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
51-347 |
2.50e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 74.12 E-value: 2.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 51 QMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMALVQNTTSLYIVRFLLGAAEAG 130
Cdd:cd17324 24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 131 FFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMldgwlgLRGWHLLFIIEGLPAVLLGIAAFFILRDR 210
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ------LLGWRAAFLAIAVLALLAALLLWRLLPSL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 211 PHQAAWLNDRQKTWlentlqaerqqqkqightttWQLLKHRQIWLMALIYAGASSAGTTL-SVWSPQLLKSFHLDNLTTG 289
Cdd:cd17324 178 PPKKPGSLGLLSSL--------------------LLLLRNPRLRLAYLITFLLFGGFFALyTYLAPFLTDVPGFSSSAII 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1388639982 290 LLNAIpYGLASVLMIVW-GRSSDRNNERRWHTALTLFMIAAGVFAAFINLSLPATIMIL 347
Cdd:cd17324 238 GLLLL-FGVAGVVGSPLaGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLV 295
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
49-354 |
2.71e-14 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 74.21 E-value: 2.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 49 ALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGV-VSMCMALVQNTTSLYIVRFLLGAA 127
Cdd:cd17341 22 GPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIpLLALALAVSSYWGLLVLGFLLGFA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 128 EAGFFPGVVLYLTWWIPSRYR--ARIIASF-MVAIPLANFIGSPLSGLILMLDGWLGlrgWHLLFIIEGLPAVLLGIAAF 204
Cdd:cd17341 102 GANFASGQPWASFWFPKEKIGgaAGGIAGAgNMGVAVSQLLAPLIAGAIVFDGGFVG---WRNAFFVPGILLAIAAVLVL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 205 FILRDRPHQAAWLNDRQKTWlentlqaerqqqkqightttWQLLKHRQIWLMALIYAGASSAGTTLSVWSPQLLKS-FHL 283
Cdd:cd17341 179 LFGDDLPTGKASALEFLKVQ--------------------LAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTrFGL 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388639982 284 DNLTTGLLNAIPYGLASVLMIVWGRSSDRNNERRWHTALTLFMIAAGVFAAF------INLSLPATIMILSTILIGA 354
Cdd:cd17341 239 PLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLslptsgTNLVLFLALFVALGLGAGA 315
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
31-426 |
1.96e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 71.50 E-value: 1.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 31 LVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMAL 110
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 111 VQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSplsgliLMLDGWLGLRGWHLLFI 190
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAA------ALLPPLALHYGWRAAFV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 191 IEGLPAVLLGIAAFFILRDRPhqaawlndrqktwlENTLQAERQQQKQighTTTWQLLKHRQIWLMALIYAGASSAGTTL 270
Cdd:cd17475 155 VAGLVSILAAVLFWLFYREPP--------------AASAATESASTLL---RSLKEVLRNRDVWLIAIAGALLVAPQFAL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 271 SV-WSPQLLKSFHLDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNERRWHTALTLFMIAAGVFAAFINLSLPATIMILST 349
Cdd:cd17475 218 LTfLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLV 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 350 IL-----IGAYAAKGPFWALASGwMSSTSAAAGLAAIGAIANLIGGAVMVNAYGIISERTGSHTLAMLPLAALCLAGGIA 424
Cdd:cd17475 298 LLlillgLFAIGWNGLYLTLVAE-SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALL 376
|
..
gi 1388639982 425 VL 426
Cdd:cd17475 377 LL 378
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
28-360 |
1.63e-12 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 68.80 E-value: 1.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 28 LPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPsnlaMQKVGARLWIPRIMIS----WGV 103
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPI----FGYLGDRYNRKWILAVgiliWSA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 104 VSMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLDGwlglr 183
Cdd:cd17328 77 ATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG----- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 184 GWHLLFIIEGLPAVLLGIAAFFILRDRPHQAAWLNDRQKTWLENTLQAerqqqkqighttTWQLLKHRQIWLMALIYAGA 263
Cdd:cd17328 152 GWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLAD------------LKALAKNPSFILSTLGFTAV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 264 SSAGTTLSVWSPQ-LLKSFHLDNLTTGLLNAIpYGLASVL-----MIVWGRSSDRNNERRWHT-----ALTLFMIAAGVF 332
Cdd:cd17328 220 SFVTGALAFWAPTfFLRAFGVGDLSSADVGLI-FGAITCIagvlgVLLGGILADRLRRKTPRAdplvcAVGLLAAAPFLF 298
|
330 340 350
....*....|....*....|....*....|
gi 1388639982 333 AAFIN--LSLPATIMILSTILIGAYAAKGP 360
Cdd:cd17328 299 LALVLalSNLLLAWVLLFLGEFLLSLNWAP 328
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
25-427 |
3.28e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 64.60 E-value: 3.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 25 WRILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVV 104
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 105 SMCMALVQNTTSLYIVRFLLGAAEAGFFPGVV-LYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLDGWlglR 183
Cdd:cd17355 82 LVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGW---R 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 184 GWHLLFIIegLPAVLLGIAAFFILRDRPHQAAWLNDRQKTwlentlqaerqqqkqIGHTTTW-QLLKHRQIWLMALIYAG 262
Cdd:cd17355 159 TALLVLAL--LALLVLVPVLLLLRRRPADLALRAYDDASP---------------ASPGSTLkEALRSASFWLLALAFFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 263 ASSAGTTLSVWSPQLLKSFHLDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNerRWHTALTLFMIAAGVFAAFINLSLPA 342
Cdd:cd17355 222 CGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYS--PRRLLAASYALRALGLALLLLLPFPP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 343 TIMILSTILIG-AYAAKGPFWALASGWMSSTSAAAGLAAIGAIANLIGGAVMVNAYGIISERTGSHTLAMLPLAALCLAG 421
Cdd:cd17355 300 LALLLFAALFGlGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIA 379
|
....*.
gi 1388639982 422 GIAVLA 427
Cdd:cd17355 380 ALLVLP 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
98-426 |
3.84e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 64.16 E-value: 3.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 98 MISWGVVSMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLD 177
Cdd:cd17316 73 LLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLL 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 178 GwlGLRGWHLLFIIEGLPAVLLgiaafFILRdrphqaawlndrqktwlentlqaerqqqkqightttwqllkhRQIWLMA 257
Cdd:cd17316 153 S--GDWGWRILFLIGALPALLA-----LLLR------------------------------------------RRTLLLI 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 258 LIYAGASSAGTTLSVWSPQLLKS-FHLDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNeRRWHTALTLFMIAAGVFAAFI 336
Cdd:cd17316 184 LLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG-RKKTLVIGLILSGILALPLFY 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 337 NLSLPATIMILSTILIGAYAakGPFWALASGWMSS---TSAAAGLAAIGAIANLIGGAVMVNAYGIISERTGSHTLAMLP 413
Cdd:cd17316 263 LLSGSPTLLLLLLFILSFFV--GGVWGALYAYLAElfpTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALI 340
|
330
....*....|...
gi 1388639982 414 LAALCLAGGIAVL 426
Cdd:cd17316 341 LALLAIVALIVAL 353
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
51-431 |
6.75e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 63.72 E-value: 6.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 51 QMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGArlwipRIMISWGVVSMC-----MALVQNTTSLYIVRFLLG 125
Cdd:COG0738 33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGY-----KRGLLLGLLLMAlglllFALAPSYPLLLLALFLLG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 126 AAEAGFFPGVVLYLTwWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLDgwlGLRGWHLLFIIEGLPAVLLGIAAFF 205
Cdd:COG0738 108 LGLGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLG---LSLSWHLPYLILAVLLLLLALLFLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 206 ILRDRPhqaawlndrqktwlentlqAERQQQKQIGHTTTWQLLKHRQIWLMALIYAGASSAGTTLSVWSPQLLKS-FHLD 284
Cdd:COG0738 184 SKLPEI-------------------EEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 285 NLTTGLLNAIPYGLASVLMIVWGRSSDRnneRRWHTALTLFMIAAGVFAAFINLSLPATIMILSTILIGAYAAkgPFWAL 364
Cdd:COG0738 245 EATAALGLSLFWGGMTIGRFLGGFLLKR---FGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLS--LMFPT 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1388639982 365 ASGWMSST--SAAAGLAAIGAIANLIGGAVMVNAYGIISERTGSHTLAMLPLAALCLAGGIAVLAMGRR 431
Cdd:COG0738 320 IFSLALDGlgKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKR 388
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
26-354 |
2.41e-10 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 61.87 E-value: 2.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 26 RILPFLVVS--YLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGV 103
Cdd:cd17345 1 RWQVFLGIFigYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 104 VSMCMALVQNTTS----LYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILmldGW 179
Cdd:cd17345 81 INILIGFVPSATSsvglMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGL---AI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 180 LGLRGWHLLFIIEGLPAVLLGIAAFFILRDRPhQAAWLNDRQKTWLENTLQAERQQQKQigHTTTWQL-----LKHRQIW 254
Cdd:cd17345 158 FGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTP-ESEGLPPIEEYKGDYPEEADGEEEEQ--ELSAWEIfvkyvLKNKLLW 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 255 LMALIYAGASSAGTTLSVWSPQ-LLKSFHLDNLTTGLLNAIPYGLASVLMIVWGRSSDR--NNERRWHTALTLFMIAAGV 331
Cdd:cd17345 235 YIAIANVFVYLVRYGILDWAPTyLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKlfKGRRAPTGIIFMILVIVAL 314
|
330 340
....*....|....*....|...
gi 1388639982 332 FAAFINLSLpaTIMILSTILIGA 354
Cdd:cd17345 315 IVYWLAPNV--LVDLIALIALGF 335
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
25-217 |
6.45e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.82 E-value: 6.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 25 WRILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVV 104
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 105 SMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLIlmldgwLGLRG 184
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL------VAALG 166
|
170 180 190
....*....|....*....|....*....|...
gi 1388639982 185 WHLLFIIEGLPAVLLGIAAFFILRDRPHQAAWL 217
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRLRLPESRGLLLALL 199
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
54-359 |
1.42e-08 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 56.16 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 54 EDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMALV-QNTTSLYIVRFLLGAAEAGFF 132
Cdd:TIGR00886 30 DDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGIAGGSFA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 133 PGVVlyltwWIPSRYRARIIASFM--------VAIPLANFIGSPLSGLILMLDGWLGLR--GWHLLFIIEGLPAvLLGIA 202
Cdd:TIGR00886 110 SCMP-----WISFFFPKKIQGTALglaagwgnMGGGVAQFVMPPIIGSLIFGGGQPAHLawGWAFVIVPAGILL-LPALL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 203 AFFILRDRPHQaawlndrqktwlentlqaeRQQQKQIGHTTTWQLLKHRQIWLMALIYAGASSAGTTLSVWSPQLLKS-F 281
Cdd:TIGR00886 184 IFFVGADTPPG-------------------KPATGKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDqF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 282 HLDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNERR--WHTALTLFMIAAGVFAAFI-NLSLPATIMILSTILIGAYAAK 358
Cdd:TIGR00886 245 GLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARklLMNFLGVAMGAFLVVLGLVsDGSLAAFIVLFVALFFFAGAGN 324
|
.
gi 1388639982 359 G 359
Cdd:TIGR00886 325 G 325
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
55-354 |
2.76e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 2.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 55 DLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMALVQNTTSLYIVRFLLGAAEAGFFPG 134
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 135 VVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILmldGWLGLRgwhLLFIIEGLpAVLLGIAAFFILRDRPHQA 214
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLY---QHLGFA---VLFIVAAV-LALLALLLVFLVKDPPPVA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 215 AwlndrqktwlentlqaerqqQKQIGHTTTWQLLKHRQIWLMALIYAGASSAGTTLSVWSPQLLKSFHLDNltTGLLNAI 294
Cdd:cd17489 178 A--------------------EEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN--AGLFFTV 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1388639982 295 pYGLASVLM-IVWGRSSDRNNERRwhtALTLFMIAAGVFAAFINLSLPATIMILSTILIGA 354
Cdd:cd17489 236 -YAIALLLSrPFSGKLSDRKGPKT---VIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGL 292
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
25-211 |
3.15e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 55.36 E-value: 3.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 25 WRILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVV 104
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 105 SMCMALvqnTTSLYIVRFLLG----AAEAGFFPGVVLYLTWWIPSRyRARIIASFMVAIPLANFIGSPLSGlilmldGWL 180
Cdd:cd17312 82 NIFMGF---STSLWFFAVLWGlnglFQSMGWPPCVKLLGNWFSKKE-RGTVYGIWSTSHNFGGILAPILAA------SLA 151
|
170 180 190
....*....|....*....|....*....|.
gi 1388639982 181 GLRGWHLLFIIEGLPAVLLGIAAFFILRDRP 211
Cdd:cd17312 152 SYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
12-360 |
4.42e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 55.06 E-value: 4.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 12 NDALEKETMRRVIWRILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGAR 91
Cdd:TIGR00895 3 QNNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 92 LWIPRIMISWGVVSMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPlanfIGSPLSG 171
Cdd:TIGR00895 83 RVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYP----IGAAVGG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 172 LIlmlDGWLG-LRGWHLLFIIEGL-PAVLLGIAAFFIlrdrPHQAAWLNDRQKTWLENTLQAERQQQKQIGHTTTWQLLK 249
Cdd:TIGR00895 159 FL---AGWLIpVFGWRSLFYVGGIaPLLLLLLLMRFL----PESIDFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQKS 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 250 HRQIW--LMALIYAGASSAGTT---------------LSVWSPQLLK--SFHLDNLTTGLLNAIPYGLASVLMIvwGRSS 310
Cdd:TIGR00895 232 TQGTKrsVFKALFQGKTARITVllwllyfmllvgvyfLTNWLPKLMVelGFSLSLAATGGALFNFGGVIGSIIF--GWLA 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1388639982 311 DRNNERrwhtALTLFMIAAGVFAAFINLSLPATIMILSTILIGAYAAKGP 360
Cdd:TIGR00895 310 DRLGPR----VTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGG 355
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
117-311 |
4.07e-07 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 52.05 E-value: 4.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 117 LYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLDGwlglrGWHLLFIIEGLPA 196
Cdd:TIGR00894 134 VVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWG-----GWPMIFYVFGIVG 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 197 VLLGIAAFFILRDRPHQAAWLNDRQKTWLENTLQAErqqqkqiGHTTTWQL-----LKHRQIWLMALIYAGASSAGTTLS 271
Cdd:TIGR00894 209 CAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQ-------KGSTRQSLpikaiPKSLPVWAIWFAIFGHFWLYTILP 281
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1388639982 272 VWSPQLLKS-FHLDNLTTGLLNAIPYGLASVLMIVWGRSSD 311
Cdd:TIGR00894 282 TYLPTFISWvLRVSGKENGLLSSLPYLFAWLCSIFAGYLAD 322
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
40-198 |
5.93e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 51.40 E-value: 5.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 40 IDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMALV--QNTTSL 117
Cdd:cd17380 13 ADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 118 YIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRAR---IIASFMvaiplanFIGSPLSGLI--LMLDGWlglrGWHLLFIIE 192
Cdd:cd17380 93 ILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRavsIVTAGS-------YLGTLLGGLIgpLLLEYY----GWPSVFYFF 161
|
....*.
gi 1388639982 193 GLPAVL 198
Cdd:cd17380 162 GLLGLL 167
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
6-208 |
7.13e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 7.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 6 PNRAIDNDALEKETMRRVIWRIL--PFLVVSYLVSIIdrGNIGMAALQ------MNEDLGLSKAAFGFASSLYFVAYFIF 77
Cdd:cd17325 174 PRPPPNKRAVSAARLRSGLRLLLrdRRLLALFLAIFV--LAFAFGALEpflplyAAELGGLSPAQIGLLFGAQGLASALS 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 78 EVPSNLAMQKVGARLWIPRIMISWGVVSMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMV 157
Cdd:cd17325 252 QPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNT 331
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1388639982 158 AIPLANFIGSPLSGLIlmldgwLGLRGWHLLFIIEGLpAVLLGIAAFFILR 208
Cdd:cd17325 332 AFSLGMVLGPLLGGFL------YDAFGFATPFLAAAA-LLLLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
145-357 |
1.21e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 145 SRYRARIIASFMVAIPLANFIGSPLSGLILMLDGWLGLRGWHLLFIIEGLPAVLLGIAAFFILRDRPHqaawlndrqktw 224
Cdd:COG2211 142 YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPV------------ 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 225 lentlqaeRQQQKQIGHTTTWQLLKHRQIWLMALIYAGASSAGTTLSVWSPQLLKS-FHLDNLTTGLLNAIPYGLASVLM 303
Cdd:COG2211 210 --------PEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGA 281
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1388639982 304 IVWGRSSDRNNERRWHTALTLFMIAAGVFAAFINLSLPATIMILSTILIGAYAA 357
Cdd:COG2211 282 PLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGA 335
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
54-359 |
2.87e-06 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 49.54 E-value: 2.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 54 EDLGLSKAAFGFASslyfVAYFIFEVPSNLAM----QKVGARLWIPRIMISWGVVSMCMALVQNTTSLYIVRFLLGAAEA 129
Cdd:PLN00028 64 DNLNLTKSDIGNAG----IASVSGSIFSRLAMgpvcDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 130 GFFPGvvlylTWWIPSRYRARIIASFM-VAIPLANFIGS------PLSGLILMLDGWLGLRGWHLLFIIEGLPAVLLGIA 202
Cdd:PLN00028 140 TFVSC-----QYWMSTMFNGKIVGTANgIAAGWGNLGGGvtqllmPLVFPLIKDAGAPSFTAWRIAFFVPGLLHIIMGIL 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 203 AFFILRDRPHQAAWlndrqktwlenTLQAERQQQKQIGHTTTWQLLKHRQIWLMALIYAGasSAG---TTLSVWSPQLLK 279
Cdd:PLN00028 215 VLTLGQDLPDGNYR-----------ELKKSGTMPKDSFSKVLRYGVTNYRTWILALTYGY--SFGvelTMDNIIAEYFYD 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 280 SFHLDNLTTGLLNAIpYGLAS-VLMIVWGRSSDRNNERR------WhtALTLFMIAAGVFAAFINL--SLPATIMILSTI 350
Cdd:PLN00028 282 RFGLSLETAGAIAAS-FGLMNlFARPAGGYLSDVAARRFgmrgrlW--ALWIVQTLGGVFCIWLGRanSLGAAIVVMILF 358
|
....*....
gi 1388639982 351 LIGAYAAKG 359
Cdd:PLN00028 359 SIFVQAACG 367
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
26-211 |
9.52e-06 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 47.40 E-value: 9.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 26 RILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVS 105
Cdd:cd17488 3 HILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 106 MCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLDGWLGlrgw 185
Cdd:cd17488 83 ILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRA---- 158
|
170 180
....*....|....*....|....*.
gi 1388639982 186 hlLFIIEGLPAVLLGIAAFFILRDRP 211
Cdd:cd17488 159 --GMYVPGIIAILMGIVLCWRLRDRP 182
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
22-208 |
2.98e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 22 RVIWRILPF--LVVSYLVSIIdrGNIGMAALQ---MNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPR 96
Cdd:COG2211 222 KALLKNRPFllLLLAYLLFFL--ALALVAALLlyyFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 97 IMISWGVVSMCMALVQ--NTTSLYIVRFLLGAAEAGFF-------PGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGS 167
Cdd:COG2211 300 GLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILvlpwamlADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAG 379
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1388639982 168 PLSGLILMLDGWLG--------LRGWHLLFIIegLPAVLLGIAAFFILR 208
Cdd:COG2211 380 ALAGLLLALFGYVAgaaqspsaLTGIRLLFFL--LPAVLLLLAALLLLF 426
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
25-261 |
5.25e-05 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 45.47 E-value: 5.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 25 WR--ILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWG 102
Cdd:PRK11663 20 WRrhILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 103 VVSMCMALvqnTTSLYIVRfLLGAAEAGF----FPGVVLYLTWWIPSRYRARIIASFMVAiplANFIGSplsgLILMLDG 178
Cdd:PRK11663 100 IINILFGF---SSSLWAFA-LLWVLNAFFqgwgWPVCAKLLTAWYSRTERGGWWAIWNTA---HNVGGA----LIPLVVG 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 179 WLGLR-GWHLLFIIEGLPAVLLGIAAFFILRDR------PHQAAWLNDRqktwLENTLQAERQ--QQKQIGHTttwQLLK 249
Cdd:PRK11663 169 AIALHyGWRYGMMIAGIIAIVVGLFLCWRLRDKpqamglPSVGEWRHDA----LELAQQQEGAglSRKEILTK---YVLL 241
|
250
....*....|..
gi 1388639982 250 HRQIWLMALIYA 261
Cdd:PRK11663 242 NPYIWLLSFSYV 253
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
2-211 |
1.33e-04 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 43.93 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 2 TDQLPNRAIDndalekETMRRVIWRILPFLVVSYLVSIIDRGNIGMAALQMNEDlGLSKAAFGFASSLYFVAYFIFEVPS 81
Cdd:PRK11273 11 KARLPAAEID------PTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 82 NLAMQKVGARLWIPRIMISWGVVSMCMALVQNTTS----LYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMV 157
Cdd:PRK11273 84 GSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSsiavMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNC 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1388639982 158 AiplaNFIGSPLSGLILMLDGWLgLRGWHLLFIIEGLPAVLLGIAAFFILRDRP 211
Cdd:PRK11273 164 A----HNVGGGLPPLLFLLGMAW-FNDWHAALYMPAFAAILVALFAFAMMRDTP 212
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
51-427 |
1.87e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 43.45 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 51 QMNEDLGLSKAAFGFASSLYFVAYFifeVPSNLAMqkVGARLWIPRIMISWGVVS-----MCMALVQNTTSLYIVRFLLG 125
Cdd:cd06180 24 LMLAELGLSYAQAGWIATANYAGYL---VGALLAS--FLRRRGRARRLIRGGLLLtvlllAAMALTSGFAALLALRFLAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 126 AAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAiplaNFIGSPLSGLILMLDGWLGLrGWHLLFIIEGLPAVLLGIAAFF 205
Cdd:cd06180 99 AASAFVFVFGSNLVLHHATAAGRGHLIGLLFAG----VGLGIALSGLLVPAGLGGGL-SWRAGWLALALLSAVLLLLSFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 206 ILRDRPHQAAwlndrqktwlentlqaerqQQKQIGHTTTWqllkHRQIWLMALIYAGASSAGTTLSVWSPQLLKSFHLDN 285
Cdd:cd06180 174 LLRRGPSAPT-------------------EASAAESAPGL----NRPLWRLALAYGLFGFGYIITATFLPLIARETGAGS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 286 LTTGLLNAIpYGLASVL-MIVWGRSSDRNNERRWhTALTLFMIAAGVFAAFinLSLPATIMILSTILIGayaakGPFWAL 364
Cdd:cd06180 231 LLAGLLWSL-FGLAAVPsCFLWGALSDRWGTRRA-LAANLLVQAVGVLLPL--LSPGPAGLVLSAVLFG-----GTFMAI 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1388639982 365 asgwMSSTSAAAGLAAIGAIANLIGgaVMVNAYGI-----------ISERTGSHTLAMLPLAALCLAGGIAVLA 427
Cdd:cd06180 302 ----TALVMALARELAPPAAPRALA--LMTASFGVgqilgpllagwLADATGGFAPALILAAAALVVAALLALL 369
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
55-206 |
2.43e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 43.33 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 55 DLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGAR--LWIPRI--MISWgvvsMCMALVQNTTSLYIVRFLLGAAEAG 130
Cdd:cd17358 35 SLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKrtLLISAIpcILGW----LLIAFAKDVWMLYLGRFLAGFGGGA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 131 FFPGVVLYLTWWIPSRYRARIIASFMVA----IPLANFIGSPLSglilmldgwlglrgWHLLFIIEGLPAVLLGIAAFFI 206
Cdd:cd17358 111 ASVVVPVYIAEIAPKNVRGALGSLNQLLvnigILLGYVLGSFLP--------------WRTLALIGAIPPVVFLILLFFI 176
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
68-204 |
3.86e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 42.61 E-value: 3.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 68 SLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMALVQNT--TSLYIVRFLLGAAEAGFFPGVVLYLTWWIPS 145
Cdd:cd17318 63 SSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGgyGALIVLRILQGLAQGVTFPAMHALWAKWAPP 142
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1388639982 146 RYRARIIASFMVAIPLANFIGSPLSGLILMLDGW---------LGLrGWHLLFIIEGLPAVLLGIAAF 204
Cdd:cd17318 143 LERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWpsifyifggLGL-LWCLLWFFLVLPVWAIVVAHF 209
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
31-354 |
4.10e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.55 E-value: 4.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 31 LVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARlwipRIMIsWGVV-----S 105
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRK----RVFL-IGLAlfglaS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 106 MCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILmldgwlGLRGW 185
Cdd:cd17321 76 LLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLL------ELFGW 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 186 HLLFIIeglpAVLLGIAAFFIlrdrphqaawlndrqktwlentlqaerqqqkqightttwqllkHRQIWLMALIYAGASS 265
Cdd:cd17321 150 RWIFLI----NVPIGLVALLL-------------------------------------------ARTFSGAVLAAFLLGA 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 266 AGTTLSVWSPQLLKS-FHLDNLTTGLLnAIPYGLASVLMIVW-GRSSDRNNERRWHTALTLFMIAAGVFAAFINLSLPAT 343
Cdd:cd17321 183 ALGGLLFLLPLYLQGvLGYSPLQAGLA-LLPLALAMLVAAPLaGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVW 261
|
330
....*....|.
gi 1388639982 344 IMILSTILIGA 354
Cdd:cd17321 262 LLLPGLVLLGL 272
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
109-354 |
4.62e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 42.18 E-value: 4.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 109 ALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIgsplsglILMLDGWLGLRGWHLL 188
Cdd:cd17473 83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVV-------FLLLGGALAEIGWRAP 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 189 FIIEGLPAVLLGIAAFFILRDRPhqaawlndrqktwlentlqaeRQQQKQIGHTTTWQLLKHRQIWLMALIYAGASSAGT 268
Cdd:cd17473 156 FLVYLLALPVLILVLLFLPEPAR---------------------KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFY 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 269 TLSVWSPQLLKSFHL-DNLTTGLLNAIPyGLASVLMIVWGRSSDRNNERRWHTALTLFMIAAGVFaaFINLSLPATIMIL 347
Cdd:cd17473 215 VIPIQLPFLLQERGGgSAALIGLALAIA-SLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFL--LLALASGLWVVLL 291
|
....*..
gi 1388639982 348 STILIGA 354
Cdd:cd17473 292 GAILAGL 298
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-211 |
1.07e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.01 E-value: 1.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 23 VIWRILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPrIMISWG 102
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLV-LAIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 103 VVSMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWW---IPSRYRARIIASFMVAIPLANFIGSPLSGLIlmldgw 179
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAaelFPKKARGTASGLVNTFGFLGGALGPLLVGYL------ 330
|
170 180 190
....*....|....*....|....*....|..
gi 1388639982 180 LGLRGWHLLFIIEGLPAVLLGIAAFFILRDRP 211
Cdd:COG2271 331 LDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
25-361 |
1.86e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 40.40 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 25 WRILPFLVVSYLVSIIDRGNIGMAALQMNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVV 104
Cdd:cd17343 2 LTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 105 SMCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLdgwlglRG 184
Cdd:cd17343 82 TVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALS------YG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 185 WHLLFIIEGLPAVLLGIAAFFILRDRPhqaawlndrQKTWLENTLQAERQQQKQI---GHTTTWQLLKHRQIWLMALIYA 261
Cdd:cd17343 156 WRSTLSISGTVAVVMSVVCLLFIKNEP---------SDVGLNNIEEEESKGKKKKsprGESTLKELLLSPFLWLLSLGYL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 262 GASSAGTTLSVWS----------PQLLKSFHLDNLTT-GLLNAIPYGLASVLMIVWGRSSDRNNERrwHTALTLFMIAAG 330
Cdd:cd17343 227 VVFGVKTAVTDWGqlfliqdkgqSALTGSSFMSSLEVgGFVGSIAAGYLSDWAVAKHGSSSRGNPR--MPLALVFMAGLT 304
|
330 340 350
....*....|....*....|....*....|....*
gi 1388639982 331 V----FAAFINLSLPATIMILSTILIGAyAAKGPF 361
Cdd:cd17343 305 VslhlFRVHITSDSSELFILLLGFLIGF-SLYGPI 338
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
54-206 |
1.89e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.29 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 54 EDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGARLWIPRIMISWGVVSMCMALVQNTTSLYIVRFLLGAAEAGFFP 133
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNV 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388639982 134 GVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLDgwlglrGWHLLFIIEGLPAVLLGIAAFFI 206
Cdd:cd06173 317 PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL------GLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
109-361 |
1.93e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 40.36 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 109 ALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSGLILMLDGwlGLRGWHLL 188
Cdd:cd17371 82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLP--PEIAWRVL 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 189 FIIEGLPAVLlgiaAFFILRDRPHQAAWLNDRQKtwlentlqaeRQQQKQIGHTTTWQLLKHRQIWLMA-LIYAGASSAG 267
Cdd:cd17371 160 FLLGALPALL----VLFIRRFVKEPPQWQAARAA----------RRHFADRPSLRELFSPPLLRTTLLAsLLATGALGGY 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 268 TTLSVWSPQLLKS-FHLDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNeRRWHTALtLFMIAAGVFAAFINLSLPATIM- 345
Cdd:cd17371 226 YGITTWLPSYLTGeRGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIG-RRNNFAL-FALGSAISILLYFFLPLSPTLIl 303
|
250 260
....*....|....*....|
gi 1388639982 346 ----ILSTILIGAYAAKGPF 361
Cdd:cd17371 304 ilgfPLGFFASGPFSGMGAY 323
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
184-350 |
2.01e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 40.36 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 184 GWHLLFIIEGLpavlLGIAAFFILRDrphqaawlndrqktwLENTLQAERQQQKQIGHTTTWQLLKH--RQIWLMALIYA 261
Cdd:cd17367 173 GWRIPFLLGGV----LAVVVLWLRRG---------------LEETESFEAIAESNEASAGTLRELRRhpRELLLVVGLTA 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 262 GASSAGTTLSVWSPQLLKS-FHLDNLTTGLLNAIPYGLASVLMIVWGRSSDRNNERRwhtaltlFMIAAGVFAAfinlsl 340
Cdd:cd17367 234 GGTLAFYTWTTYLQKFLVNtAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRP-------LLLFFGIGGT------ 300
|
170
....*....|
gi 1388639982 341 PATIMILSTI 350
Cdd:cd17367 301 LATVPLLSAL 310
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
16-183 |
5.17e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.78 E-value: 5.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 16 EKETMRRVIWRILPF---LVVSYLVSIIdrgnIGMAALQMNEDLGLS-KAAFGFASSLYFVAYFIFEVP------SNLAM 85
Cdd:cd17391 185 KKMVSTKEVWNSVPNpslLISLFVTTFI----IQLANQSIEPILTLYiRQLMGDASNLAFISGLVFSATgvssllSAPRL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 86 QKVGARLWIPRIMISWGVVS----MCMALVQNTTSLYIVRFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPL 161
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASallyIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYL 340
|
170 180
....*....|....*....|..
gi 1388639982 162 ANFIGSPLSGLIlmlDGWLGLR 183
Cdd:cd17391 341 GNVAGPLLGSAI---AAHFGYR 359
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
45-204 |
5.38e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 38.72 E-value: 5.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 45 IGMAALQMNEDLGLSKAAFGFASSLYFVAYFIfevpSNLAMQKVGARLWIPRIMI----SWGVVSMCMALVQNTTSLYIV 120
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAI----GALLAGPLADRFGRKRVLLvsvaLFGLFTLLTAFAQSVLQLALL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 121 RFLLGAAEAGFFPGVVLYLTWWIPSRYRARIIASFMVAIPLANFIGSPLSglILMLDGWlglrGWHLLFIIEGLPAVLLG 200
Cdd:cd17365 94 RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLA--AALIPAF----GWRSVFLLGGVPPLILL 167
|
....
gi 1388639982 201 IAAF 204
Cdd:cd17365 168 PLLR 171
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
52-353 |
7.00e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.36 E-value: 7.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 52 MNEDLGLSKAAFGFASSLYFVAYFIFEVPSNLAMQKVGAR--LWIPRIMISWGVVSMcmALVQNTTSLYIVRFLLGAAEA 129
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRkaILIGGILFGLGFILS--AFAISLPLLFLGYGVLGGIGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 130 GF-FPGVVLYLTWWIPSRyraRIIASFMVA--IPLANFIGSPLSGLILmldgwlGLRGWHLLFIIEGLP-AVLLGIAAFF 205
Cdd:cd17353 107 GIgYITPVSTAVKWFPDK---RGLATGIVIagFGLGSLIFSPLIAYLI------NTVGVPTTFLILGIIfLIIIVIGAFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388639982 206 ILRDRPHQAAWLNDRQKTWLENTlqaerqqqkqIGHTTTWQLLKHRQIWLMALIYAGASSAGTTLSVWSPQLLKSFHLDN 285
Cdd:cd17353 178 IRDPPKGWVPPGVDPLANNAENS----------PRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLD 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1388639982 286 LTTGLLNAIPYGLASVL-MIVWGRSSDRNneRRWHTALTLFMIAAGVFAAFINLSLPATIMILSTILIG 353
Cdd:cd17353 248 AGIAALAVSILSIFNGGgRPFWGWLSDKI--GRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIG 314
|
|
| |
