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Conserved domains on  [gi|1388116445|gb|AWI67063|]
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DNA helicase RecQ, partial [Orpinomyces joyonii]

Protein Classification

HRDC domain-containing protein( domain architecture ID 10456725)

Helicase and RNase D C-terminal (HRDC) domain-containing protein similar to Deinococcus radiodurans DNA helicase RecQ

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HRDC pfam00570
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ...
 323-389 1.10e-16

HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.


:

Pssm-ID: 425755 [Multi-domain]  Cd Length: 68  Bit Score: 74.49  E-value: 1.10e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116445 323 KELFERLRILRYEFAKKNNIPAFSVFPNSVLIDMCVKLPMDNEKFLNIYGVGKEKLNKYGKEFMKEI 389
Cdd:pfam00570   2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
HRDC pfam00570
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ...
 28-94 7.08e-13

HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.


:

Pssm-ID: 425755 [Multi-domain]  Cd Length: 68  Bit Score: 63.32  E-value: 7.08e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116445  28 KELFEKLKILRNEFAKKNNIAPFIVFPKSVLIDMCIELPMDDEKFLNIYRVNKEKLNKYGKEFMKEI 94
Cdd:pfam00570   2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
HRDC pfam00570
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ...
 193-259 5.09e-12

HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.


:

Pssm-ID: 425755 [Multi-domain]  Cd Length: 68  Bit Score: 61.01  E-value: 5.09e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116445 193 EELFDKLKALRNKLTEKNNIESFSVFSNSVLIEMCVKLPMDDKKFLNIHRVDKEKLNKYGKEFMKEI 259
Cdd:pfam00570   2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
 
Name Accession Description Interval E-value
HRDC pfam00570
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ...
 323-389 1.10e-16

HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.


Pssm-ID: 425755 [Multi-domain]  Cd Length: 68  Bit Score: 74.49  E-value: 1.10e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116445 323 KELFERLRILRYEFAKKNNIPAFSVFPNSVLIDMCVKLPMDNEKFLNIYGVGKEKLNKYGKEFMKEI 389
Cdd:pfam00570   2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
HRDC smart00341
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ...
 323-395 1.27e-15

Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.


Pssm-ID: 128635 [Multi-domain]  Cd Length: 81  Bit Score: 71.56  E-value: 1.27e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388116445  323 KELFERLRILRYEFAKKNNIPAFSVFPNSVLIDMCVKLPMDNEKFLNIYGVGKEKLNKYGKEFMKEIKDFVEN 395
Cdd:smart00341   5 LRLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVIQEASDS 77
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 315-396 1.91e-13

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 72.82  E-value: 1.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116445 315 QDKLTAKG--KELFERLRILRYEFAKKNNIPAFSVFPNSVLIDMCVKLPMDNEKFLNIYGVGKEKLNKYGKEFMKEIKDF 392
Cdd:PRK11057  523 MQKSFGGNydRKLFAKLRKLRKSIADEENIPPYVVFNDATLIEMAEQMPITASEMLSVNGVGQRKLERFGKPFMALIRAH 602


                  ....
gi 1388116445 393 VENN 396
Cdd:PRK11057  603 VDGD 606
HRDC pfam00570
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ...
 28-94 7.08e-13

HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.


Pssm-ID: 425755 [Multi-domain]  Cd Length: 68  Bit Score: 63.32  E-value: 7.08e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116445  28 KELFEKLKILRNEFAKKNNIAPFIVFPKSVLIDMCIELPMDDEKFLNIYRVNKEKLNKYGKEFMKEI 94
Cdd:pfam00570   2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
HRDC smart00341
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ...
 28-100 1.14e-12

Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.


Pssm-ID: 128635 [Multi-domain]  Cd Length: 81  Bit Score: 63.47  E-value: 1.14e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388116445   28 KELFEKLKILRNEFAKKNNIAPFIVFPKSVLIDMCIELPMDDEKFLNIYRVNKEKLNKYGKEFMKEIKDFVEN 100
Cdd:smart00341   5 LRLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVIQEASDS 77
HRDC pfam00570
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ...
 193-259 5.09e-12

HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.


Pssm-ID: 425755 [Multi-domain]  Cd Length: 68  Bit Score: 61.01  E-value: 5.09e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116445 193 EELFDKLKALRNKLTEKNNIESFSVFSNSVLIEMCVKLPMDDKKFLNIHRVDKEKLNKYGKEFMKEI 259
Cdd:pfam00570   2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 28-101 1.99e-11

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 66.28  E-value: 1.99e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1388116445  28 KELFEKLKILRNEFAKKNNIAPFIVFPKSVLIDMCIELPMDDEKFLNIYRVNKEKLNKYGKEFMKEIKDFVENN 101
Cdd:PRK11057  533 RKLFAKLRKLRKSIADEENIPPYVVFNDATLIEMAEQMPITASEMLSVNGVGQRKLERFGKPFMALIRAHVDGD 606
HRDC smart00341
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ...
 189-265 2.59e-11

Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.


Pssm-ID: 128635 [Multi-domain]  Cd Length: 81  Bit Score: 59.62  E-value: 2.59e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116445  189 TEKGEELFDKLKALRNKLTEKNNIESFSVFSNSVLIEMCVKLPMDDKKFLNIHRVDKEKLNKYGKEFMKEIKEFVEN 265
Cdd:smart00341   1 RERQLRLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVIQEASDS 77
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 168-266 1.08e-10

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 63.96  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116445 168 KLKALRNKLKRKILKRDQDiltekgEELFDKLKALRNKLTEKNNIESFSVFSNSVLIEMCVKLPMDDKKFLNIHRVDKEK 247
Cdd:PRK11057  514 RIVALKPRAMQKSFGGNYD------RKLFAKLRKLRKSIADEENIPPYVVFNDATLIEMAEQMPITASEMLSVNGVGQRK 587

                          90
                  ....*....|....*....
gi 1388116445 248 LNKYGKEFMKEIKEFVENN 266
Cdd:PRK11057  588 LERFGKPFMALIRAHVDGD 606
 
Name Accession Description Interval E-value
HRDC pfam00570
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ...
 323-389 1.10e-16

HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.


Pssm-ID: 425755 [Multi-domain]  Cd Length: 68  Bit Score: 74.49  E-value: 1.10e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116445 323 KELFERLRILRYEFAKKNNIPAFSVFPNSVLIDMCVKLPMDNEKFLNIYGVGKEKLNKYGKEFMKEI 389
Cdd:pfam00570   2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
HRDC smart00341
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ...
 323-395 1.27e-15

Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.


Pssm-ID: 128635 [Multi-domain]  Cd Length: 81  Bit Score: 71.56  E-value: 1.27e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388116445  323 KELFERLRILRYEFAKKNNIPAFSVFPNSVLIDMCVKLPMDNEKFLNIYGVGKEKLNKYGKEFMKEIKDFVEN 395
Cdd:smart00341   5 LRLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVIQEASDS 77
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 315-396 1.91e-13

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 72.82  E-value: 1.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116445 315 QDKLTAKG--KELFERLRILRYEFAKKNNIPAFSVFPNSVLIDMCVKLPMDNEKFLNIYGVGKEKLNKYGKEFMKEIKDF 392
Cdd:PRK11057  523 MQKSFGGNydRKLFAKLRKLRKSIADEENIPPYVVFNDATLIEMAEQMPITASEMLSVNGVGQRKLERFGKPFMALIRAH 602


                  ....
gi 1388116445 393 VENN 396
Cdd:PRK11057  603 VDGD 606
HRDC pfam00570
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ...
 28-94 7.08e-13

HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.


Pssm-ID: 425755 [Multi-domain]  Cd Length: 68  Bit Score: 63.32  E-value: 7.08e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116445  28 KELFEKLKILRNEFAKKNNIAPFIVFPKSVLIDMCIELPMDDEKFLNIYRVNKEKLNKYGKEFMKEI 94
Cdd:pfam00570   2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
HRDC smart00341
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ...
 28-100 1.14e-12

Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.


Pssm-ID: 128635 [Multi-domain]  Cd Length: 81  Bit Score: 63.47  E-value: 1.14e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388116445   28 KELFEKLKILRNEFAKKNNIAPFIVFPKSVLIDMCIELPMDDEKFLNIYRVNKEKLNKYGKEFMKEIKDFVEN 100
Cdd:smart00341   5 LRLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVIQEASDS 77
HRDC pfam00570
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ...
 193-259 5.09e-12

HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.


Pssm-ID: 425755 [Multi-domain]  Cd Length: 68  Bit Score: 61.01  E-value: 5.09e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116445 193 EELFDKLKALRNKLTEKNNIESFSVFSNSVLIEMCVKLPMDDKKFLNIHRVDKEKLNKYGKEFMKEI 259
Cdd:pfam00570   2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 28-101 1.99e-11

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 66.28  E-value: 1.99e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1388116445  28 KELFEKLKILRNEFAKKNNIAPFIVFPKSVLIDMCIELPMDDEKFLNIYRVNKEKLNKYGKEFMKEIKDFVENN 101
Cdd:PRK11057  533 RKLFAKLRKLRKSIADEENIPPYVVFNDATLIEMAEQMPITASEMLSVNGVGQRKLERFGKPFMALIRAHVDGD 606
HRDC smart00341
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ...
 189-265 2.59e-11

Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.


Pssm-ID: 128635 [Multi-domain]  Cd Length: 81  Bit Score: 59.62  E-value: 2.59e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1388116445  189 TEKGEELFDKLKALRNKLTEKNNIESFSVFSNSVLIEMCVKLPMDDKKFLNIHRVDKEKLNKYGKEFMKEIKEFVEN 265
Cdd:smart00341   1 RERQLRLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVIQEASDS 77
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 168-266 1.08e-10

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 63.96  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116445 168 KLKALRNKLKRKILKRDQDiltekgEELFDKLKALRNKLTEKNNIESFSVFSNSVLIEMCVKLPMDDKKFLNIHRVDKEK 247
Cdd:PRK11057  514 RIVALKPRAMQKSFGGNYD------RKLFAKLRKLRKSIADEENIPPYVVFNDATLIEMAEQMPITASEMLSVNGVGQRK 587

                          90
                  ....*....|....*....
gi 1388116445 248 LNKYGKEFMKEIKEFVENN 266
Cdd:PRK11057  588 LERFGKPFMALIRAHVDGD 606
PLN03137 PLN03137
ATP-dependent DNA helicase; Q4-like; Provisional
 325-410 1.12e-04

ATP-dependent DNA helicase; Q4-like; Provisional


Pssm-ID: 215597 [Multi-domain]  Cd Length: 1195  Bit Score: 44.89  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388116445  325 LFERLRILRYEFAKK--NNIPAFSVFPNSVLIDMCVKLPMDNEKFLNIYGVGKEKLNKYGKEFMKEI----KDFVENNPN 398
Cdd:PLN03137  1031 LYTALRKLRTALVKEagDGVMAYHIFGNATLQQISKRIPRTKEELLEINGLGKAKVSKYGDRLLETIestiNEYYKTDKN 1110

                           90
                   ....*....|..
gi 1388116445  399 VITSKKDDVNIK 410
Cdd:PLN03137  1111 SSSSNDSPDSGK 1122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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