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Conserved domains on  [gi|1387845369|ref|NP_001350075|]
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nicotinate phosphoribosyltransferase isoform 4 [Homo sapiens]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 37-297 2.71e-112

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member TIGR01513:

Pssm-ID: 473867 [Multi-domain]  Cd Length: 443  Bit Score: 332.02  E-value: 2.71e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  37 HPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKVFRAAAaqfqv 116
Cdd:TIGR01513 201 FDNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQLDAAG----- 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 117 pwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAF 196
Cdd:TIGR01513 275 --LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMKLSENPEKSTLPGRKQVF 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 197 RLLGSDGSPLMDMLQLAEEPVPQAgqelrvwppgAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQLSLSRL 276
Cdd:TIGR01513 353 RLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKL 422

                         250       260
                  ....*....|....*....|.
gi 1387845369 277 SPEHRRLRSPAQYQVVLSERL 297
Cdd:TIGR01513 423 PPEYLRLLNPHVYPVSLSPRL 443
 
Name Accession Description Interval E-value
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 37-297 2.71e-112

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 332.02  E-value: 2.71e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  37 HPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKVFRAAAaqfqv 116
Cdd:TIGR01513 201 FDNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQLDAAG----- 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 117 pwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAF 196
Cdd:TIGR01513 275 --LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMKLSENPEKSTLPGRKQVF 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 197 RLLGSDGSPLMDMLQLAEEPVPQAgqelrvwppgAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQLSLSRL 276
Cdd:TIGR01513 353 RLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKL 422

                         250       260
                  ....*....|....*....|.
gi 1387845369 277 SPEHRRLRSPAQYQVVLSERL 297
Cdd:TIGR01513 423 PPEYLRLLNPHVYPVSLSPRL 443
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
 2-297 2.85e-94

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 289.25  E-value: 2.85e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369   2 LAPAAGEGPGVDLAAKAQVWLE--QVCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALAL 79
Cdd:PLN02885  227 LRSADGSSVCEDFVSLVQEWLSklQESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALAL 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  80 GELGYRAVGVRLDSGDLLQQAQEIRKVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQ 159
Cdd:PLN02885  307 NDLGYKAVGIRLDSGDLAYLSLEARKFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYA 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 160 QPSLGGVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQelRVW---PPGAQEPCT 236
Cdd:PLN02885  387 QPALGCVYKLVEINGQPRIKLSEDVEKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAY 464

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1387845369 237 VRPAQVEPLLRlCLQQGQLCEP---LPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 297
Cdd:PLN02885  465 VVPQRVEELLK-CYWDGSSGKPreeLPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 37-304 8.43e-61

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 199.99  E-value: 8.43e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  37 HPGERAAFVAYALAFPRAFQGLLDTYSVWrSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRKVFRAAAaqf 114
Cdd:COG1488   205 HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARELLDEAG--- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 115 qvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGG----QPRMKLTEDPEKQTLP 190
Cdd:COG1488   278 ----LPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdgewRPVIKLSETPGKKSKP 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 191 GSKAAFRlLGSDGSPLMDMLQLAEEPVPQAGqelrvwppgaqepctvrpaqvEPLLRLCLQQGQLCEPLPSLAESRALAQ 270
Cdd:COG1488   354 GRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYELPSLEEIRERAA 411

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1387845369 271 LSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSL 304
Cdd:COG1488   412 AQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 37-170 4.81e-58

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 189.32  E-value: 4.81e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  37 HPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKVFRAAAaqfqv 116
Cdd:cd01570   201 FDDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKMLDEAG----- 275

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1387845369 117 pwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLV 170
Cdd:cd01570   276 --LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
NAPRTase_C pfam17956
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ...
 193-300 1.07e-32

Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.


Pssm-ID: 465585 [Multi-domain]  Cd Length: 111  Bit Score: 116.90  E-value: 1.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 193 KAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGA-QEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQL 271
Cdd:pfam17956   2 KQVYRLYDKDGKAIADLITLADEPPPDPGEEILCFHPFDeWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81

                          90       100
                  ....*....|....*....|....*....
gi 1387845369 272 SLSRLSPEHRRLRSPAQYQVVLSERLQAL 300
Cdd:pfam17956  82 QLSRLWPEHKRLLNPHPYKVDLSEKLYQL 110
 
Name Accession Description Interval E-value
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 37-297 2.71e-112

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 332.02  E-value: 2.71e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  37 HPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKVFRAAAaqfqv 116
Cdd:TIGR01513 201 FDNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQLDAAG----- 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 117 pwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAF 196
Cdd:TIGR01513 275 --LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMKLSENPEKSTLPGRKQVF 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 197 RLLGSDGSPLMDMLQLAEEPVPQAgqelrvwppgAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQLSLSRL 276
Cdd:TIGR01513 353 RLYDATGKFLGDELTLADEPIEDL----------NQEKCTPVFAPVEPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKL 422

                         250       260
                  ....*....|....*....|.
gi 1387845369 277 SPEHRRLRSPAQYQVVLSERL 297
Cdd:TIGR01513 423 PPEYLRLLNPHVYPVSLSPRL 443
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
 2-297 2.85e-94

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 289.25  E-value: 2.85e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369   2 LAPAAGEGPGVDLAAKAQVWLE--QVCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALAL 79
Cdd:PLN02885  227 LRSADGSSVCEDFVSLVQEWLSklQESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALAL 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  80 GELGYRAVGVRLDSGDLLQQAQEIRKVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQ 159
Cdd:PLN02885  307 NDLGYKAVGIRLDSGDLAYLSLEARKFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYA 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 160 QPSLGGVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQelRVW---PPGAQEPCT 236
Cdd:PLN02885  387 QPALGCVYKLVEINGQPRIKLSEDVEKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGE--RILcrhPFNESKRAY 464

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1387845369 237 VRPAQVEPLLRlCLQQGQLCEP---LPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 297
Cdd:PLN02885  465 VVPQRVEELLK-CYWDGSSGKPreeLPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
PRK09243 PRK09243
nicotinate phosphoribosyltransferase; Validated
 37-297 5.80e-71

nicotinate phosphoribosyltransferase; Validated


Pssm-ID: 236426 [Multi-domain]  Cd Length: 464  Bit Score: 226.58  E-value: 5.80e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  37 HPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNflAVALAlGEL--GYRAVGVRLDSGDLLQQAQEIRKVFRAAAaqf 114
Cdd:PRK09243  210 FDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPN--AIKVA-KELgdGIELGGVRIDSGDLAYLSKKVRKMLDEAG--- 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 115 qvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGG----QPRMKLTEDPEKQTLP 190
Cdd:PRK09243  284 ----FTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVTGSDAPALGGVYKLVAIEGeggmIPKIKLSNSPEKVTTP 359

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 191 GSKAAFRLLGSDGSPLMDMLQLAEEPVpqaGQELRVW-PPGAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALA 269
Cdd:PRK09243  360 GRKQVYRIYDKGGKAEADVITLADEEE---EEPLKMFhPVHTYKSKTVKNFDAEPLLVPVMENGKRVYELPSLEEIRAYA 436

                         250       260
                  ....*....|....*....|....*...
gi 1387845369 270 QLSLSRLSPEHRRLRSPAQYQVVLSERL 297
Cdd:PRK09243  437 AAQLASLPEEYKRLLNPHAYPVDLSQAL 464
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 37-304 8.43e-61

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 199.99  E-value: 8.43e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  37 HPGERAAFVAYALAFPRAFQGLLDTYSVWrSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRKVFRAAAaqf 114
Cdd:COG1488   205 HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARELLDEAG--- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 115 qvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGG----QPRMKLTEDPEKQTLP 190
Cdd:COG1488   278 ----LPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdgewRPVIKLSETPGKKSKP 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 191 GSKAAFRlLGSDGSPLMDMLQLAEEPVPQAGqelrvwppgaqepctvrpaqvEPLLRLCLQQGQLCEPLPSLAESRALAQ 270
Cdd:COG1488   354 GRKQVYR-RDEDGKATADLVALEDEPLPGEP---------------------EPLLVPVFRDGKLVYELPSLEEIRERAA 411

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1387845369 271 LSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSL 304
Cdd:COG1488   412 AQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 37-170 4.81e-58

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 189.32  E-value: 4.81e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  37 HPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKVFRAAAaqfqv 116
Cdd:cd01570   201 FDDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKMLDEAG----- 275

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1387845369 117 pwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLV 170
Cdd:cd01570   276 --LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
PRK12484 PRK12484
nicotinate phosphoribosyltransferase; Provisional
 35-306 4.33e-48

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 237112 [Multi-domain]  Cd Length: 443  Bit Score: 166.46  E-value: 4.33e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  35 EPHPGERAAFVAYALAFPRAFQGLLDTYSVWRsGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKVFRAAAaqf 114
Cdd:PRK12484  202 EAFPDEVAAFRAFARLYPDATTLLVDTYDTLR-GVRNAIEVAKELGN-RFDPRGVRLDSGDLAELSKATRAILDAAG--- 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 115 qvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTedPEKQTLPGSKA 194
Cdd:PRK12484  277 ----LEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADAPVLDSAYKLVAYEGRGVTKLS--SGKVTYPGRKQ 350

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 195 AFRLLGSdGSPLMDMLQLAEEPVpqagqelrvwPPGAqepctvrpaqvEPLLRLCLQQGQLCEPLPSLAESRALAQLSLS 274
Cdd:PRK12484  351 VFRLYEH-GTACGDVIGLHTENI----------PDGR-----------EPLLVPVMTNGRRIQHAPTLDGARDWCEAQLA 408

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1387845369 275 RLSPEHRRLRSPAQYQVVLSERLQALVNSLCA 306
Cdd:PRK12484  409 ALPPEARRLVDPVAVSVTLSGELARLRHADTA 440
NAPRTase_C pfam17956
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ...
 193-300 1.07e-32

Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.


Pssm-ID: 465585 [Multi-domain]  Cd Length: 111  Bit Score: 116.90  E-value: 1.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369 193 KAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGA-QEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQL 271
Cdd:pfam17956   2 KQVYRLYDKDGKAIADLITLADEPPPDPGEEILCFHPFDeWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYVQE 81

                          90       100
                  ....*....|....*....|....*....
gi 1387845369 272 SLSRLSPEHRRLRSPAQYQVVLSERLQAL 300
Cdd:pfam17956  82 QLSRLWPEHKRLLNPHPYKVDLSEKLYQL 110
NAPRTase_PncB cd01567
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ...
 40-168 3.57e-26

Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238801 [Multi-domain]  Cd Length: 343  Bit Score: 105.81  E-value: 3.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  40 ERAAFVAYALAFPRAFQGLL----DTYSVWRsGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKVFRAAAAqfq 115
Cdd:cd01567   216 EEAAFEAFARWLPQFGGGLGialiDTYDTDN-GFLNALKLAKALGA-GGGLLGVRLDSGDPVELIKKVRKHLDELGI--- 290

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1387845369 116 vpWLESVLIVVSNNID-EEALARL-AQEGSEVNVIGIGTSVVTCPQQPSLGGVYK 168
Cdd:cd01567   291 --DLNKKKIIISGDLDtEEAIELLlEQGASPNDAFGVGTSLTNDLGRPPLGFVYK 343
PRTase_typeII cd00516
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ...
 39-168 9.53e-18

Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.


Pssm-ID: 238286 [Multi-domain]  Cd Length: 281  Bit Score: 81.52  E-value: 9.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  39 GERAAFVAYALAFPRAFQGLLDTYSVWrsgLPNFLAVALALgelgyRAVGVRLDSGDL--LQQAQEIRKVFRAaaaqFQV 116
Cdd:cd00516   167 GELAAVKALRRWLPELFIALIDVEVDT---LEEALEAAKAG-----GADGIRLDSGSPeeLDPAVLILKARAH----LDG 234

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1387845369 117 PWLESVLIVVSNNIDEEALARLAQEGseVNVIGIGTSVVTCpqqPSLGGVYK 168
Cdd:cd00516   235 KGLPRVKIEASGGLDEENIRAYAETG--VDVFGVGTLLHSA---PPLDIVLK 281
PncB_like cd01401
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ...
 87-188 1.31e-03

Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.


Pssm-ID: 238695 [Multi-domain]  Cd Length: 377  Bit Score: 39.92  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  87 VGVRLDSGDLLQQAQEIRKvfraaaaqfqvpWLESV-------LIVVSNNIDEEA---LARLAQEGseVNVI-GIGTS-- 153
Cdd:cd01401   275 DGVRHDSGDPFEWGEKAIA------------HYEKLgidpktkTLVFSDGLDVEKaleLYEYFKGR--IKVSfGIGTNlt 340

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1387845369 154 --VVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEKQT 188
Cdd:cd01401   341 ndFGNKEKSTPLNIVIKLVECNGRPVAKISDSPGKNM 377
PRK05321 PRK05321
nicotinate phosphoribosyltransferase; Provisional
 88-188 1.59e-03

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 235406 [Multi-domain]  Cd Length: 400  Bit Score: 39.74  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387845369  88 GVRLDSGDLLQQAQEIrkvfraaaaqfqVPWLESV-------LIVVSNNID-EEALARLAQEGSEVNVI-GIGTSVvTC- 157
Cdd:PRK05321  279 GLRHDSGDPIEWGEKA------------IAHYEKLgidprtkTLVFSDGLDfDKALELYRHFKGRIKLSfGIGTNL-TNd 345

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1387845369 158 -PQQPSLGGVYKLVAVGGQPRMKLTEDPEKQT 188
Cdd:PRK05321  346 fPGVKPLNIVIKLVECNGRPVAKLSDSPGKTM 377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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