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Conserved domains on  [gi|1384865967|ref|NP_001349770|]
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calcium/calmodulin-dependent protein kinase kinase 1 [Mus musculus]

Protein Classification

calcium/calmodulin-dependent protein kinase kinase 1( domain architecture ID 10197729)

calcium/calmodulin-dependent protein kinase kinase 1 (CaMKK1) is a serine/threonine-protein kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates; CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
STKc_CaMKK1 cd14200
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; ...
127-410 0e+00

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK1, also called CaMKK alpha, is involved in the regulation of glucose uptake in skeletal muscles, independently of AMPK and PKB activation. It also play roles in learning and memory. Studies on CaMKK1 knockout mice reveal deficits in fear conditioning. The CaMKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


:

Pssm-ID: 271102 [Multi-domain]  Cd Length: 284  Bit Score: 578.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQATQGGPAKQLLPLERVYQEIAILKKL 206
Cdd:cd14200     1 QYKLQSEIGKGSYGVVKLAYNESDDKYYAMKVLSKKKLLKQYGFPRRPPPRGSKAAQGEQAKPLAPLERVYQEIAILKKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd14200    81 DHVNIVKLIEVLDDPAEDNLYMVFDLLRKGPVMEVPSDKPFSEDQARLYFRDIVLGIEYLHYQKIVHRDIKPSNLLLGDD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIK 366
Cdd:cd14200   161 GHVKIADFGVSNQFEGNDALLSSTAGTPAFMAPETLSDSGQSFSGKALDVWAMGVTLYCFVYGKCPFIDEFILALHNKIK 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 367 NEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd14200   241 NKPVEFPEEPEISEELKDLILKMLDKNPETRITVPEIKVHPWVT 284
 
Name Accession Description Interval E-value
STKc_CaMKK1 cd14200
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; ...
127-410 0e+00

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK1, also called CaMKK alpha, is involved in the regulation of glucose uptake in skeletal muscles, independently of AMPK and PKB activation. It also play roles in learning and memory. Studies on CaMKK1 knockout mice reveal deficits in fear conditioning. The CaMKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271102 [Multi-domain]  Cd Length: 284  Bit Score: 578.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQATQGGPAKQLLPLERVYQEIAILKKL 206
Cdd:cd14200     1 QYKLQSEIGKGSYGVVKLAYNESDDKYYAMKVLSKKKLLKQYGFPRRPPPRGSKAAQGEQAKPLAPLERVYQEIAILKKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd14200    81 DHVNIVKLIEVLDDPAEDNLYMVFDLLRKGPVMEVPSDKPFSEDQARLYFRDIVLGIEYLHYQKIVHRDIKPSNLLLGDD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIK 366
Cdd:cd14200   161 GHVKIADFGVSNQFEGNDALLSSTAGTPAFMAPETLSDSGQSFSGKALDVWAMGVTLYCFVYGKCPFIDEFILALHNKIK 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 367 NEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd14200   241 NKPVEFPEEPEISEELKDLILKMLDKNPETRITVPEIKVHPWVT 284
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
128-409 6.50e-88

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 270.17  E-value: 6.50e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYgfprrppprgsqatqggpakqllplERVYQEIAILKKLD 207
Cdd:smart00220   1 YEILEKLGEGSFGKVYLARDKKTGKLVAIKVIKKKKIKKDR-------------------------ERILREIKILKKLK 55
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  208 HVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:smart00220  56 HPNIVRLYDVFEDE--DKLYLVMEYCEGGDLFDLLKKRgRLSEDEARFYLRQILSALEYLHSKGIVHRDLKPENILLDED 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  287 GHVKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDY-ILTLHRKI 365
Cdd:smart00220 134 GHVKLADFGLARQLDPGE-KLTTFVGTPEYMAPEVL--LGKGYGKAV-DIWSLGVILYELLTGKPPFPGDDqLLELFKKI 209
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1384865967  366 KNEAVVFPE-EPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:smart00220 210 GKPKPPFPPpEWDISPEAKDLIRKLLVKDPEKRLTAEEALQHPFF 254
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
122-397 6.11e-50

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 177.90  E-value: 6.11e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 122 CVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLLP--------L 193
Cdd:COG0515     3 ALLLGRYRILRLLGRGGMGVVYLARDLRLGRPVAL-------------------------------KVLRPelaadpeaR 51
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVldDPAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:COG0515    52 ERFRREARALARLNHPNIVRVYDV--GEEDGRPYLVMEYVEGESLADlLRRRGPLPPAEALRILAQLAEALAAAHAAGIV 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSST-AGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKC 351
Cdd:COG0515   130 HRDIKPANILLTPDGRVKLIDFGIARALGGATLTQTGTvVGTPGYMAPEQA--RGEPVDPRS-DVYSLGVTLYELLTGRP 206
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 352 PFIDDYILTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETR 397
Cdd:COG0515   207 PFDGDSPAELLRAHLREPPPPPSElrPDLPPALDAIVLRALAKDPEER 254
Pkinase pfam00069
Protein kinase domain;
128-409 1.98e-42

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 150.47  E-value: 1.98e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYgfprrppprgsqatqggpakqllpLERVYQEIAILKKLD 207
Cdd:pfam00069   1 YEVLRKLGSGSFGTVYKAKHRDTGKIVAIKKIKKEKIKKKK------------------------DKNILREIKILKKLN 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEylhcqkivhrdikpsnlllgdd 286
Cdd:pfam00069  57 HPNIVRLYDAFEDK--DNLYLVLEYVEGGSLFDlLSEKGAFSEREAKFIMKQILEGLE---------------------- 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 ghvkiadfgvsnqfegNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIK 366
Cdd:pfam00069 113 ----------------SGSSLTTFVGTPWYMAPEVLGGNPY---GPKVDVWSLGCILYELLTGKPPFPGINGNEIYELII 173
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 367 NEAVVFPEEP-EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:pfam00069 174 DQPYAFPELPsNLSEEAKDLLKKLLKKDPSKRLTATQALQHPWF 217
PTZ00263 PTZ00263
protein kinase A catalytic subunit; Provisional
124-408 2.37e-38

protein kinase A catalytic subunit; Provisional


Pssm-ID: 140289 [Multi-domain]  Cd Length: 329  Bit Score: 142.65  E-value: 2.37e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 124 QLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPPPRGSQatqggpakqllpLERVYQEIAIL 203
Cdd:PTZ00263   16 KLSDFEMGETLGTGSFGRVRIAKHKGTGEYYAIKC-----------LKKREILKMKQ------------VQHVAQEKSIL 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 204 KKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:PTZ00263   73 MELSHPFIVNMMCSFQD--ENRVYFLLEFVVGGELFtHLRKAGRFPNDVAKFYHAELVLAFEYLHSKDIIYRDLKPENLL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 LGDDGHVKIADFGVSNQFEGNDAQLsstAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLH 362
Cdd:PTZ00263  151 LDNKGHVKVTDFGFAKKVPDRTFTL---CGTPEYLAPEVIQSKGH---GKAVDWWTMGVLLYEFIAGYPPFFDDTPFRIY 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 363 RKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRI-----GVSDIKLHPW 408
Cdd:PTZ00263  225 EKILAGRLKFPN--WFDGRARDLVKGLLQTDHTKRLgtlkgGVADVKNHPY 273
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
205-397 4.13e-18

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 87.16  E-value: 4.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKlieVLDDPAEDNL-YLVF---------DLLRKGpvmevpcdKPFPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:NF033483   63 SLSHPNIVS---VYDVGEDGGIpYIVMeyvdgrtlkDYIREH--------GPLSPEEAVEIMIQILSALEHAHRNGIVHR 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFG----VSNQfegNDAQLSSTAGTPAFMAPEAISDS---GQSfsgkalDVWATGVTLYCFV 347
Cdd:NF033483  132 DIKPQNILITKDGRVKVTDFGiaraLSST---TMTQTNSVLGTVHYLSPEQARGGtvdARS------DIYSLGIVLYEML 202
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 348 YGKCPFIDDYILTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETR 397
Cdd:NF033483  203 TGRPPFDGDSPVSVAYKHVQEDPPPPSElnPGIPQSLDAVVLKATAKDPDDR 254
 
Name Accession Description Interval E-value
STKc_CaMKK1 cd14200
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; ...
127-410 0e+00

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK1, also called CaMKK alpha, is involved in the regulation of glucose uptake in skeletal muscles, independently of AMPK and PKB activation. It also play roles in learning and memory. Studies on CaMKK1 knockout mice reveal deficits in fear conditioning. The CaMKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271102 [Multi-domain]  Cd Length: 284  Bit Score: 578.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQATQGGPAKQLLPLERVYQEIAILKKL 206
Cdd:cd14200     1 QYKLQSEIGKGSYGVVKLAYNESDDKYYAMKVLSKKKLLKQYGFPRRPPPRGSKAAQGEQAKPLAPLERVYQEIAILKKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd14200    81 DHVNIVKLIEVLDDPAEDNLYMVFDLLRKGPVMEVPSDKPFSEDQARLYFRDIVLGIEYLHYQKIVHRDIKPSNLLLGDD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIK 366
Cdd:cd14200   161 GHVKIADFGVSNQFEGNDALLSSTAGTPAFMAPETLSDSGQSFSGKALDVWAMGVTLYCFVYGKCPFIDEFILALHNKIK 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 367 NEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd14200   241 NKPVEFPEEPEISEELKDLILKMLDKNPETRITVPEIKVHPWVT 284
STKc_CAMKK cd14118
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; ...
133-410 0e+00

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271020 [Multi-domain]  Cd Length: 275  Bit Score: 510.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 133 EIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGsqaTQGGPAKQLLPLERVYQEIAILKKLDHVNVV 212
Cdd:cd14118     1 EIGKGSYGIVKLAYNEEDNTLYAMKILSKKKLLKQAGFFRRPPPRR---KPGALGKPLDPLDRVYREIAILKKLDHPNVV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 213 KLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd14118    78 KLVEVLDDPNEDNLYMVFELVDKGAVMEVPTDNPLSEETARSYFRDIVLGIEYLHYQKIIHRDIKPSNLLLGDDGHVKIA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVF 372
Cdd:cd14118   158 DFGVSNEFEGDDALLSSTAGTPAFMAPEALSESRKKFSGKALDIWAMGVTLYCFVFGRCPFEDDHILGLHEKIKTDPVVF 237
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1384865967 373 PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd14118   238 PDDPVVSEQLKDLILRMLDKNPSERITLPEIKEHPWVT 275
STKc_CaMKK2 cd14199
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; ...
125-410 1.92e-168

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK2, also called CaMKK beta, is one of the most versatile CaMKs. It is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. CaMKK2 contains unique N- and C-terminal domains and a central catalytic kinase domain that is followed by a regulatory domain that bears overlapping autoinhibitory and CaM-binding regions. It can be activated by signaling through G-coupled receptors, IP3 receptors, plasma membrane ion channels, and Toll-like receptors. Thus, CaMKK2 acts as a molecular hub that is capable of receiving and decoding signals from diverse pathways. The CaMKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271101 [Multi-domain]  Cd Length: 286  Bit Score: 476.77  E-value: 1.92e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQATQGGPAKQLLPLERVYQEIAILK 204
Cdd:cd14199     1 LNQYKLKDEIGKGSYGVVKLAYNEDDNTYYAMKVLSKKKLMRQAGFPRRPPPRGARAAPEGCTQPRGPIERVYQEIAILK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14199    81 KLDHPNVVKLVEVLDDPSEDHLYMVFELVKQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDVKPSNLLVG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRK 364
Cdd:cd14199   161 EDGHIKIADFGVSNEFEGSDALLTNTVGTPAFMAPETLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERILSLHSK 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1384865967 365 IKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd14199   241 IKTQPLEFPDQPDISDDLKDLLFRMLDKNPESRISVPEIKLHPWVT 286
STKc_LKB1_CaMKK cd14008
Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent ...
134-409 7.85e-131

Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Both LKB1 and CaMKKs can phosphorylate and activate AMP-activated protein kinase (AMPK). LKB1, also called STK11, serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMPK. Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The LKB1/CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270910 [Multi-domain]  Cd Length: 267  Bit Score: 380.36  E-value: 7.85e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSqatqggpakqllPLERVYQEIAILKKLDHVNVVK 213
Cdd:cd14008     1 LGRGSFGKVKLALDTETGQLYAIKIFNKSRLRKRREGKNDRGKIKN------------ALDDVRREIAIMKKLDHPNIVR 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDK---PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVK 290
Cdd:cd14008    69 LYEVIDDPESDKLYLVLEYCEGGPVMELDSGDrvpPLPEETARKYFRDLVLGLEYLHENGIVHRDIKPENLLLTADGTVK 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 291 IADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAV 370
Cdd:cd14008   149 ISDFGVSEMFEDGNDTLQKTAGTPAFLAPELCDGDSKTYSGKAADIWALGVTLYCLVFGRLPFNGDNILELYEAIQNQND 228
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1384865967 371 VFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14008   229 EFPIPPELSPELKDLLRRMLEKDPEKRITLKEIKEHPWV 267
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
128-409 6.50e-88

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 270.17  E-value: 6.50e-88
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYgfprrppprgsqatqggpakqllplERVYQEIAILKKLD 207
Cdd:smart00220   1 YEILEKLGEGSFGKVYLARDKKTGKLVAIKVIKKKKIKKDR-------------------------ERILREIKILKKLK 55
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  208 HVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:smart00220  56 HPNIVRLYDVFEDE--DKLYLVMEYCEGGDLFDLLKKRgRLSEDEARFYLRQILSALEYLHSKGIVHRDLKPENILLDED 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  287 GHVKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDY-ILTLHRKI 365
Cdd:smart00220 134 GHVKLADFGLARQLDPGE-KLTTFVGTPEYMAPEVL--LGKGYGKAV-DIWSLGVILYELLTGKPPFPGDDqLLELFKKI 209
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1384865967  366 KNEAVVFPE-EPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:smart00220 210 GKPKPPFPPpEWDISPEAKDLIRKLLVKDPEKRLTAEEALQHPFF 254
STKc_AMPK-like cd14003
Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze ...
127-408 2.20e-78

Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The AMPK-like subfamily is composed of AMPK, MARK, BRSK, NUAK, MELK, SNRK, TSSK, and SIK, among others. LKB1 serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. BRSKs play important roles in establishing neuronal polarity. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. The AMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270905 [Multi-domain]  Cd Length: 252  Bit Score: 245.50  E-value: 2.20e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfPRRPPPRGSQatqggpakqllplERVYQEIAILKKL 206
Cdd:cd14003     1 NYELGKTLGEGSFGKVKLARHKLTGEKVAIKII-----------DKSKLKEEIE-------------EKIKREIEIMKLL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGD 285
Cdd:cd14003    57 NHPNIIKLYEVIETE--NKIYLVMEYASGGELFDYIVNNgRLSEDEARRFFQQLISAVDYCHSNGIVHRDLKLENILLDK 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DGHVKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKI 365
Cdd:cd14003   135 NGNLKIIDFGLSNEFRGGS-LLKTFCGTPAYAAPEVL--LGRKYDGPKADVWSLGVILYAMLTGYLPFDDDNDSKLFRKI 211
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1384865967 366 KNEavVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14003   212 LKG--KYPIPSHLSPDARDLIRRMLVVDPSKRITIEEILNHPW 252
STKc_CAMK cd05117
The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of ...
127-408 4.25e-72

The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. CAMKIV is implicated in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors, as well as in T-cell development and signaling. The CAMK family also consists of other related kinases including the Phosphorylase kinase Gamma subunit (PhKG), the C-terminal kinase domains of Ribosomal S6 kinase (RSK) and Mitogen and stress-activated kinase (MSK), Doublecortin-like kinase (DCKL), and the MAPK-activated protein kinases MK2, MK3, and MK5, among others. The CAMK family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270687 [Multi-domain]  Cd Length: 258  Bit Score: 229.67  E-value: 4.25e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPPPRGSQatqggpakqllplERVYQEIAILKKL 206
Cdd:cd05117     1 KYELGKVLGRGSFGVVRLAVHKKTGEEYAVKI-----------IDKKKLKSEDE-------------EMLRREIEILKRL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL-- 283
Cdd:cd05117    57 DHPNIVKLYEVFED--DKNLYLVMELCTGGELFDRIVKKgSFSEREAAKIMKQILSAVAYLHSQGIVHRDLKPENILLas 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 -GDDGHVKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLH 362
Cdd:cd05117   135 kDPDSPIKIIDFGLAKIFEEGE-KLKTVCGTPYYVAPEVLKGKGY---GKKCDIWSLGVILYILLCGYPPFYGETEQELF 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 363 RKIKNEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd05117   211 EKILKGKYSFDSPEwkNVSEEAKDLIKRLLVVDPKKRLTAAEALNHPW 258
STKc_LKB1 cd14119
Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer ...
194-409 1.14e-70

Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LKB1, also called STK11, was first identified as a tumor suppressor responsible for Peutz-Jeghers syndrome, a disorder that leads to an increased risk of spontaneous epithelial cancer. It serves as a master upstream kinase that activates AMP-activated protein kinase (AMPK) and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. To be activated, LKB1 requires the adaptor proteins STe20-Related ADaptor (STRAD) and mouse protein 25 (MO25). The LKB1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271021 [Multi-domain]  Cd Length: 255  Bit Score: 225.60  E-value: 1.14e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVF--------DLLRKGPvmevpcDKPFPEEQARLYLRDIILGLEY 265
Cdd:cd14119    39 ANVKREIQILRRLNHRNVIKLVDVLYNEEKQKLYMVMeycvgglqEMLDSAP------DKRLPIWQAHGYFVQLIDGLEY 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ---FEGNDAqLSSTAGTPAFMAPEaISDSGQSFSGKALDVWATGVT 342
Cdd:cd14119   113 LHSQGIIHKDIKPGNLLLTTDGTLKISDFGVAEAldlFAEDDT-CTTSQGSPAFQPPE-IANGQDSFSGFKVDIWSAGVT 190
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 343 LYCFVYGKCPFIDDYILTLHRKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14119   191 LYNMTTGKYPFEGDNIYKLFENIGKGEYTIP--DDVDPDLQDLLRGMLEKDPEKRFTIEQIRQHPWF 255
STKc_AGC cd05123
Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
134-408 7.73e-62

Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AGC kinases regulate many cellular processes including division, growth, survival, metabolism, motility, and differentiation. Many are implicated in the development of various human diseases. Members of this family include cAMP-dependent Protein Kinase (PKA), cGMP-dependent Protein Kinase (PKG), Protein Kinase C (PKC), Protein Kinase B (PKB), G protein-coupled Receptor Kinase (GRK), Serum- and Glucocorticoid-induced Kinase (SGK), and 70 kDa ribosomal Protein S6 Kinase (p70S6K or S6K), among others. AGC kinases share an activation mechanism based on the phosphorylation of up to three sites: the activation loop (A-loop), the hydrophobic motif (HM) and the turn motif. Phosphorylation at the A-loop is required of most AGC kinases, which results in a disorder-to-order transition of the A-loop. The ordered conformation results in the access of substrates and ATP to the active site. A subset of AGC kinases with C-terminal extensions containing the HM also requires phosphorylation at this site. Phosphorylation at the HM allows the C-terminal extension to form an ordered structure that packs into the hydrophobic pocket of the catalytic domain, which then reconfigures the kinase into an active bi-lobed state. In addition, growth factor-activated AGC kinases such as PKB, p70S6K, RSK, MSK, PKC, and SGK, require phosphorylation at the turn motif (also called tail or zipper site), located N-terminal to the HM at the C-terminal extension. The AGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and Phosphoinositide 3-Kinase.


Pssm-ID: 270693 [Multi-domain]  Cd Length: 250  Bit Score: 202.75  E-value: 7.73e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQL--------LPLERVYQEIAILKK 205
Cdd:cd05123     1 LGKGSFGKVLLVRKKDTGKLYAM-------------------------------KVLrkkeiikrKEVEHTLNERNILER 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDpaEDNLYLV---------FDLLRKGPVmevpcdkpFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd05123    50 VNHPFIVKLHYAFQT--EEKLYLVldyvpggelFSHLSKEGR--------FPEERARFYAAEIVLALEYLHSLGIIYRDL 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDD 356
Cdd:cd05123   120 KPENILLDSDGHIKLTDFGLAKELSSDGDRTYTFCGTPEYLAPEVLLGKGY---GKAVDWWSLGVLLYEMLTGKPPFYAE 196
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 357 YILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIG---VSDIKLHPW 408
Cdd:cd05123   197 NRKEIYEKILKSPLKFPE--YVSPEAKSLISGLLQKDPTKRLGsggAEEIKAHPF 249
STKc_BRSK1_2 cd14081
Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the ...
127-409 2.50e-61

Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BRSK1, also called SAD-B or SAD1 (Synapses of Amphids Defective homolog 1), and BRSK2, also called SAD-A, are highly expressed in mammalian forebrain. They play important roles in establishing neuronal polarity. BRSK1/2 double knock-out mice die soon after birth, showing thin cerebral cortices due to disordered subplate layers and neurons that lack distinct axons and dendrites. BRSK1 regulates presynaptic neurotransmitter release. Its activity fluctuates during cell cysle progression and it acts as a regulator of centrosome duplication. BRSK2 is also abundant in pancreatic islets, where it is involved in the regulation of glucose-stimulated insulin secretion. The BRSK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270983 [Multi-domain]  Cd Length: 255  Bit Score: 201.33  E-value: 2.50e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprRPPPRGSQATQGGPAKqllpLERvyqEIAILKKL 206
Cdd:cd14081     2 PYRLGKTLGKGQTGLVKLAKHCVTGQKVAI----------------KIVNKEKLSKESVLMK----VER---EIAIMKLI 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGD 285
Cdd:cd14081    59 EHPNVLKLYDVYENKKY--LYLVLEYVSGGELFDYLVKKgRLTEKEARKFFRQIISALDYCHSHSICHRDLKPENLLLDE 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DGHVKIADFGVSNqFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKI 365
Cdd:cd14081   137 KNNIKIADFGMAS-LQPEGSLLETSCGSPHYACPEVI--KGEKYDGRKADIWSCGVILYALLVGALPFDDDNLRQLLEKV 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 366 KNEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14081   214 KRGVFHIP--HFISPDAQDLLRRMLEVNPEKRITIEEIKKHPWF 255
PKc_STE cd05122
Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the ...
128-409 2.76e-60

Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. This family is composed of STKs, and some dual-specificity PKs that phosphorylate both threonine and tyrosine residues of target proteins. Most members are kinases involved in mitogen-activated protein kinase (MAPK) signaling cascades, acting as MAPK kinases (MAPKKs), MAPKK kinases (MAPKKKs), or MAPKKK kinases (MAP4Ks). The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPKK, which itself is phosphorylated and activated by a MAPKKK. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAPKKK to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Other STE family members include p21-activated kinases (PAKs) and class III myosins, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain, which can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, as well as autophosphorylate the C-terminal motor domain. They play an important role in maintaining the structural integrity of photoreceptor cell microvilli. The STE family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270692 [Multi-domain]  Cd Length: 254  Bit Score: 198.58  E-value: 2.76e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfpRRPPPRGSQAtqggpakqllpLERVYQEIAILKKLD 207
Cdd:cd05122     2 FEILEKIGKGGFGVVYKARHKKTGQIVAI---------------KKINLESKEK-----------KESILNEIAILKKCK 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIE-VLDDpaeDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd05122    56 HPNIVKYYGsYLKK---DELWIVMEFCSGGSLKDLlkNTNKTLTEQQIAYVCKEVLKGLEYLHSHGIIHRDIKAANILLT 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLHRK 364
Cdd:cd05122   133 SDGEVKLIDFGLSAQLS-DGKTRNTFVGTPYWMAPEVI--QGKPYGFKA-DIWSLGITAIEMAEGKPPYSELPPMKALFL 208
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1384865967 365 I-KNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd05122   209 IaTNGPPGLRNPKKWSKEFKDFLKKCLQKDPEKRPTAEQLLKHPFI 254
STKc_Aurora cd14007
Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of ...
134-410 2.20e-57

Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Yeast contains only one Aurora kinase while most higher eukaryotes have two. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2. Aurora-B is most active at the transition during metaphase to the end of mitosis. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270909 [Multi-domain]  Cd Length: 253  Bit Score: 191.15  E-value: 2.20e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLLplervyQEIAILKKLDHVNVVK 213
Cdd:cd14007     8 LGKGKFGNVYLAREKKSGFIVALKVI-----------------SKSQLQKSGLEHQLR------REIEIQSHLRHPNILR 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDpaEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd14007    65 LYGYFED--KKRIYLILEYAPNGELYkELKKQKRFDEKEAAKYIYQLALALDYLHSKNIIHRDIKPENILLGSNGELKLA 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGVSNqfEGNDAQLSSTAGTPAFMAPEAIsdSGQSFsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVF 372
Cdd:cd14007   143 DFGWSV--HAPSNRRKTFCGTLDYLPPEMV--EGKEY-DYKVDIWSLGVLCYELLVGKPPFESKSHQETYKRIQNVDIKF 217
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1384865967 373 PeePEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd14007   218 P--SSVSPEAKDLISKLLQKDPSKRLSLEQVLNHPWIK 253
PKc cd00180
Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group ...
134-407 4.06e-56

Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.


Pssm-ID: 270622 [Multi-domain]  Cd Length: 215  Bit Score: 186.32  E-value: 4.06e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLLP------LERVYQEIAILKKLD 207
Cdd:cd00180     1 LGKGSFGKVYKARDKETGKKVAV-------------------------------KVIPKeklkklLEELLREIEILKKLN 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGD 285
Cdd:cd00180    50 HPNIVKLYDVFET--ENFLYLVMEYCEGGSLKDLlkENKGPLSEEEALSILRQLLSALEYLHSNGIIHRDLKPENILLDS 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DGHVKIADFGVSNQFEGNDAQLSSTAG--TPAFMAPEAIsdsGQSFSGKALDVWATGVTLYCFvygkcpfiddyiltlhr 363
Cdd:cd00180   128 DGTVKLADFGLAKDLDSDDSLLKTTGGttPPYYAPPELL---GGRYYGPKVDIWSLGVILYEL----------------- 187
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 364 kikneavvfpeepevsEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd00180   188 ----------------EELKDLIRRMLQYDPKKRPSAKELLEHL 215
STKc_PLK cd14099
Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the ...
193-408 1.01e-55

Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. PLKs derive their names from homology to polo, a kinase first identified in Drosophila. There are five mammalian PLKs (PLK1-5) from distinct genes. There is good evidence that PLK1 may function as an oncogene while PLK2-5 have tumor suppressive properties. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. PLK2 functions in G1 progression, S-phase arrest, and centriole duplication. PLK3 regulates angiogenesis and responses to DNA damage. PLK4 is required for late mitotic progression, cell survival, and embryonic development. PLK5 was first identified as a pseudogene containing a stop codon within the kinase domain, however, both murine and human genes encode expressed proteins. PLK5 functions in cell cycle arrest.


Pssm-ID: 271001 [Multi-domain]  Cd Length: 258  Bit Score: 186.99  E-value: 1.01e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd14099    45 REKLKSEIKIHRSLKHPNIVKFHDCFED--EENVYILLELCSNGSLMElLKRRKALTEPEVRYFMRQILSGVKYLHSNRI 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDS-GQSFSgkaLDVWATGVTLYCFVYGK 350
Cdd:cd14099   123 IHRDLKLGNLFLDENMNVKIGDFGLAARLEYDGERKKTLCGTPNYIAPEVLEKKkGHSFE---VDIWSLGVILYTLLVGK 199
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 351 CPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14099   200 PPFETSDVKETYKRIKKNEYSFPSHLSISDEAKDLIRSMLQPDPTKRPSLDEILSHPF 257
STKc_SnRK3 cd14663
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
127-408 1.28e-55

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK3 is represented in this cd. The SnRK3 group contains members also known as CBL-interacting protein kinase, salt overly sensitive 2, SOS3-interacting proteins and protein kinase S. These kinases interact with calcium-binding proteins such as SOS3, SCaBPs, and CBL proteins, and are involved in responses to salt stress and in sugar and ABA signaling. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271133 [Multi-domain]  Cd Length: 256  Bit Score: 186.46  E-value: 1.28e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrppprgSQATQGGPAKQLlplervYQEIAILKKL 206
Cdd:cd14663     1 RYELGRTLGEGTFAKVKFARNTKTGESVAIKIIDK-----------------EQVAREGMVEQI------KREIAIMKLL 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGD 285
Cdd:cd14663    58 RHPNIVELHEVM--ATKTKIFFVMELVTGGELFSkIAKNGRLKEDKARKYFQQLIDAVDYCHSRGVFHRDLKPENLLLDE 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DGHVKIADFGVSNQFEGN--DAQLSSTAGTPAFMAPEAISDSGqsFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHR 363
Cdd:cd14663   136 DGNLKISDFGLSALSEQFrqDGLLHTTCGTPNYVAPEVLARRG--YDGAKADIWSCGVILFVLLAGYLPFDDENLMALYR 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1384865967 364 KIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14663   214 KIMKGEFEYP--RWFSPGAKSLIKRILDPNPSTRITVEQIMASPW 256
STKc_PknB_like cd14014
Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs ...
127-397 3.41e-53

Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270916 [Multi-domain]  Cd Length: 260  Bit Score: 180.48  E-value: 3.41e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLLP--------LERVYQ 198
Cdd:cd14014     1 RYRLVRLLGRGGMGEVYRARDTLLGRPVAI-------------------------------KVLRPelaedeefRERFLR 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEV-PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd14014    50 EARALARLSHPNIVRVYDVGED--DGRPYIVMEYVEGGSLADLlRERGPLPPREALRILAQIADALAAAHRAGIVHRDIK 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 278 PSNLLLGDDGHVKIADFGVSNQFEGND-AQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDD 356
Cdd:cd14014   128 PANILLTEDGRVKLTDFGIARALGDSGlTQTGSVLGTPAYMAPEQA--RGGPVDPRS-DIYSLGVVLYELLTGRPPFDGD 204
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1384865967 357 YILTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETR 397
Cdd:cd14014   205 SPAAVLAKHLQEAPPPPSPlnPDVPPALDAIILRALAKDPEER 247
STKc_AMPK_alpha cd14079
Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein ...
194-408 7.23e-53

Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. In response to decreased ATP levels, it enhances energy-producing processes and inhibits energy-consuming pathways. Once activated, AMPK phosphorylates a broad range of downstream targets, with effects in carbohydrate metabolism and uptake, lipid and fatty acid biosynthesis, carbon energy storage, and inflammation, among others. Defects in energy homeostasis underlie many human diseases including Type 2 diabetes, obesity, heart disease, and cancer. As a result, AMPK has emerged as a therapeutic target in the treatment of these diseases. The AMPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270981 [Multi-domain]  Cd Length: 256  Bit Score: 179.39  E-value: 7.23e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd14079    47 EKIRREIQILKLFRHPHIIRLYEVIETPTD--IFMVMEYVSGGELFDYIVQKgRLSEDEARRFFQQIISGVEYCHRHMVV 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCP 352
Cdd:cd14079   125 HRDLKPENLLLDSNMNVKIADFGLSNIMRDGEF-LKTSCGSPNYAAPEVI--SGKLYAGPEVDVWSCGVILYALLCGSLP 201
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 353 FIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14079   202 FDDEHIPNLFKKIKSGIYTIPS--HLSPGARDLIKRMLVVDPLKRITIPEIRQHPW 255
STKc_MAPKKK cd06606
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase ...
134-409 5.88e-52

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKKKs (MKKKs or MAP3Ks) are also called MAP/ERK kinase kinases (MEKKs) in some cases. They phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. This subfamily is composed of the Apoptosis Signal-regulating Kinases ASK1 (or MAPKKK5) and ASK2 (or MAPKKK6), MEKK1, MEKK2, MEKK3, MEKK4, as well as plant and fungal MAPKKKs. Also included in this subfamily are the cell division control proteins Schizosaccharomyces pombe Cdc7 and Saccharomyces cerevisiae Cdc15. The MAPKKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270783 [Multi-domain]  Cd Length: 258  Bit Score: 176.94  E-value: 5.88e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKvlskkkllkqygfprrppprgSQATQGGPAKQLLPLERvyqEIAILKKLDHVNVVK 213
Cdd:cd06606     8 LGKGSFGSVYLALNLDTGELMAVK---------------------EVELSGDSEEELEALER---EIRILSSLKHPNIVR 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 lieVLDDPAEDNLYLVF----------DLLRKGpvmevpcdKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd06606    64 ---YLGTERTENTLNIFleyvpggslaSLLKKF--------GKLPEPVVRKYTRQILEGLEYLHSNGIVHRDIKGANILV 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 GDDGHVKIADFGVSNQFEGND--AQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPF--IDDYIL 359
Cdd:cd06606   133 DSDGVVKLADFGCAKRLAEIAtgEGTKSLRGTPYWMAPEVIRGEGY---GRAADIWSLGCTVIEMATGKPPWseLGNPVA 209
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 360 TLHRKIKNEAVvfPEEPE-VSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06606   210 ALFKIGSSGEP--PPIPEhLSEEAKDFLRKCLQRDPKKRPTADELLQHPFL 258
STKc_Cdc7_like cd06627
Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs ...
127-409 2.89e-50

Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include Schizosaccharomyces pombe Cdc7, Saccharomyces cerevisiae Cdc15, Arabidopsis thaliana mitogen-activated protein kinase kinase kinase (MAPKKK) epsilon, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Cdc7 is essential for cell division by playing a key role in the initiation of septum formation and cytokinesis. Budding yeast Cdc15 functions to coordinate mitotic exit with cytokinesis. Arabidopsis MAPKKK epsilon is required for pollen development in the plasma membrane. The Cdc7-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270797 [Multi-domain]  Cd Length: 254  Bit Score: 172.41  E-value: 2.89e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLLP-------LERVYQE 199
Cdd:cd06627     1 NYQLGDLIGRGAFGSVYKGLNLNTGEFVAI-------------------------------KQISLekipksdLKSVMGE 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 200 IAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVpCDK--PFPEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd06627    50 IDLLKKLNHPNIVKYIGSVKT--KDSLYIILEYVENGSLASI-IKKfgKFPESLVAVYIYQVLEGLAYLHEQGVIHRDIK 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 278 PSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFsgkALDVWATGVTLYCFVYGKCPFID-D 356
Cdd:cd06627   127 GANILTTKDGLVKLADFGVATKLNEVEKDENSVVGTPYWMAPEVIEMSGVTT---ASDIWSVGCTVIELLTGNPPYYDlQ 203
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 357 YILTLHRKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06627   204 PMAALFRIVQDDHPPLP--ENISPELRDFLLQCFQKDPTLRPSAKELLKHPWL 254
STKc_MAST_like cd05579
Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs ...
134-408 5.39e-50

Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAST kinases, MAST-like (MASTL) kinases (also called greatwall kinase or Gwl), and fungal kinases with similarity to Saccharomyces cerevisiae Rim15 and Schizosaccharomyces pombe cek1. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. MASTL kinases carry only a catalytic domain which contains a long insert relative to other kinases. The fungal kinases in this subfamily harbor other domains in addition to a central catalytic domain, which like in MASTL, also contains an insert relative to MAST kinases. Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MASTL/Gwl is involved in the regulation of mitotic entry, mRNA stabilization, and DNA checkpoint recovery. The fungal proteins Rim15 and cek1 are involved in the regulation of meiosis and mitosis, respectively. The MAST-like kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270731 [Multi-domain]  Cd Length: 272  Bit Score: 172.40  E-value: 5.39e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPPPRGSQatqggpakqllpLERVYQEIAILKKLDHVNVVK 213
Cdd:cd05579     1 ISRGAYGRVYLAKKKSTGDLYAIKV-----------IKKRDMIRKNQ------------VDSVLAERNILSQAQNPFVVK 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDpaEDNLYLVFDLLRKGPV----MEVPCdkpFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHV 289
Cdd:cd05579    58 LYYSFQG--KKNLYLVMEYLPGGDLysllENVGA---LDEDVARIYIAEIVLALEYLHSHGIIHRDLKPDNILIDANGHL 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 290 KIADFGVS---------------NQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFsgkALDVWATGVTLYCFVYGKCPFI 354
Cdd:cd05579   133 KLTDFGLSkvglvrrqiklsiqkKSNGAPEKEDRRIVGTPDYLAPEILLGQGHGK---TVDWWSLGVILYEFLVGIPPFH 209
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 355 DDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIG---VSDIKLHPW 408
Cdd:cd05579   210 AETPEEIFQNILNGKIEWPEDPEVSDEAKDLISKLLTPDPEKRLGakgIEEIKNHPF 266
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
122-397 6.11e-50

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 177.90  E-value: 6.11e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 122 CVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLLP--------L 193
Cdd:COG0515     3 ALLLGRYRILRLLGRGGMGVVYLARDLRLGRPVAL-------------------------------KVLRPelaadpeaR 51
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVldDPAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:COG0515    52 ERFRREARALARLNHPNIVRVYDV--GEEDGRPYLVMEYVEGESLADlLRRRGPLPPAEALRILAQLAEALAAAHAAGIV 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSST-AGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKC 351
Cdd:COG0515   130 HRDIKPANILLTPDGRVKLIDFGIARALGGATLTQTGTvVGTPGYMAPEQA--RGEPVDPRS-DVYSLGVTLYELLTGRP 206
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 352 PFIDDYILTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETR 397
Cdd:COG0515   207 PFDGDSPAELLRAHLREPPPPPSElrPDLPPALDAIVLRALAKDPEER 254
STKc_Nek cd08215
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; ...
127-403 9.03e-50

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek family is composed of 11 different mammalian members (Nek1-11) with similarity to the catalytic domain of Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants that were prevented from entering mitosis. Neks contain a conserved N-terminal catalytic domain and a more divergent C-terminal regulatory region of various sizes and structures. They are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270855 [Multi-domain]  Cd Length: 258  Bit Score: 171.11  E-value: 9.03e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQ-----LLPLER--VYQE 199
Cdd:cd08215     1 KYEKIRVIGKGSFGSAYLVRRKSDGKLYVL-------------------------------KEidlsnMSEKEReeALNE 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 200 IAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEV-----PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd08215    50 VKLLSKLKHPNIVKYYESFEE--NGKLCIVMEYADGGDLAQKikkqkKKGQPFPEEQILDWFVQICLALKYLHSRKILHR 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFI 354
Cdd:cd08215   128 DLKTQNIFLTKDGVVKLGDFGISKVLESTTDLAKTVVGTPYYLSPELC--ENKPYNYKS-DIWALGCVLYELCTLKHPFE 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384865967 355 DDYILTLHRKIKNEavVFPEEPEV-SEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd08215   205 ANNLPALVYKIVKG--QYPPIPSQySSELRDLVNSMLQKDPEKRPSANEI 252
STKc_TSSK-like cd14080
Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs ...
128-409 1.14e-49

Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. TSSK6, also called SSTK, is expressed at the head of elongated sperm. TSSK1/TSSK2 double knock-out and TSSK6 null mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270982 [Multi-domain]  Cd Length: 262  Bit Score: 171.21  E-value: 1.14e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAY--NESEDRHYAMKVLSkkkllkqygfpRRPPPRGSQatqggpaKQLLPlervyQEIAILKK 205
Cdd:cd14080     2 YRLGKTIGEGSYSKVKLAEytKSGLKEKVACKIID-----------KKKAPKDFL-------EKFLP-----RELEILRK 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14080    59 LRHPNIIQVYSIFER--GSKVFIFMEYAEHGDLLEyIQKRGALSESQARIWFRQLALAVQYLHSLDIAHRDLKCENILLD 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQFEGNDAQ-LSST-AGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLH 362
Cdd:cd14080   137 SNNNVKLSDFGFARLCPDDDGDvLSKTfCGSAAYAAPEIL--QGIPYDPKKYDIWSLGVILYIMLCGSMPFDDSNIKKML 214
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 363 RKIKNEAVVFPEEPE-VSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14080   215 KDQQNRKVRFPSSVKkLSPECKDLIDQLLEPDPTKRATIEEILNHPWL 262
STKc_Yank1 cd05578
Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the ...
196-408 1.38e-48

Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily contains uncharacterized STKs with similarity to the human protein designated as Yank1 or STK32A. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270730 [Multi-domain]  Cd Length: 257  Bit Score: 168.20  E-value: 1.38e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 196 VYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPV-MEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd05578    47 VLNELEILQELEHPFLVNLWYSFQD--EEDMYMVVDLLLGGDLrYHLQQKVKFSEETVKFYICEIVLALDYLHSKNIIHR 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQFEGnDAQLSSTAGTPAFMAPEAISDSGQSFsgkALDVWATGVTLYCFVYGKCPF- 353
Cdd:cd05578   125 DIKPDNILLDEQGHVHITDFNIATKLTD-GTLATSTSGTKPYMAPEVFMRAGYSF---AVDWWSLGVTAYEMLRGKRPYe 200
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 354 ------IDDYILTLHRKIkneaVVFPeePEVSEDLKDLILRMLDKNPETRIG-VSDIKLHPW 408
Cdd:cd05578   201 ihsrtsIEEIRAKFETAS----VLYP--AGWSEEAIDLINKLLERDPQKRLGdLSDLKNHPY 256
STKc_Chk2 cd14084
Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze ...
127-409 2.81e-48

Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Checkpoint Kinase 2 (Chk2) plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The Chk2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270986 [Multi-domain]  Cd Length: 275  Bit Score: 167.95  E-value: 2.81e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygfpRRPPPRGSQATQGGPAkqllpleRVYQEIAILKKL 206
Cdd:cd14084     7 KYIMSRTLGSGACGEVKLAYDKSTCKKVAIKIIN-----------KRKFTIGSRREINKPR-------NIETEIEILKKL 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGD 285
Cdd:cd14084    69 SHPCIIKIEDFFD--AEDDYYIVLELMEGGELFDrVVSNKRLKEAICKLYFYQMLLAVKYLHSNGIIHRDLKPENVLLSS 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DGH---VKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTL-YCFVyGKCPFIDDYI-LT 360
Cdd:cd14084   147 QEEeclIKITDFGLS-KILGETSLMKTLCGTPTYLAPEVLRSFGTEGYTRAVDCWSLGVILfICLS-GYPPFSEEYTqMS 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 361 LHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14084   225 LKEQILSGKYTFipKAWKNVSEEAKDLVKKMLVVDPSRRPSIEEALEHPWL 275
STKc_PDK1 cd05581
Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs ...
126-408 3.80e-48

Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDK1 carries an N-terminal catalytic domain and a C-terminal pleckstrin homology (PH) domain that binds phosphoinositides. It phosphorylates the activation loop of AGC kinases that are regulated by PI3K such as PKB, SGK, and PKC, among others, and is crucial for their activation. Thus, it contributes in regulating many processes including metabolism, growth, proliferation, and survival. PDK1 also has the ability to autophosphorylate and is constitutively active in mammalian cells. It is essential for normal embryo development and is important in regulating cell volume. The PDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270733 [Multi-domain]  Cd Length: 278  Bit Score: 167.39  E-value: 3.80e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygfprrppprgsqatqggpaKQLLPLER----VYQEIA 201
Cdd:cd05581     1 NDFKFGKPLGEGSYSTVVLAKEKETGKEYAIKVLD---------------------------KRHIIKEKkvkyVTIEKE 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 202 ILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCD-KPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSN 280
Cdd:cd05581    54 VLSRLAHPGIVKLYYTFQD--ESKLYFVLEYAPNGDLLEYIRKyGSLDEKCTRFYTAEIVLALEYLHSKGIIHRDLKPEN 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 281 LLLGDDGHVKIADFGVSNQF-----------------EGNDAQLSSTAGTPAFMAPEAISDsgQSFsGKALDVWATGVTL 343
Cdd:cd05581   132 ILLDEDMHIKITDFGTAKVLgpdsspestkgdadsqiAYNQARAASFVGTAEYVSPELLNE--KPA-GKSSDLWALGCII 208
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 344 YCFVYGKCPFIDDYILTLHRKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVSD------IKLHPW 408
Cdd:cd05581   209 YQMLTGKPPFRGSNEYLTFQKIVKLEYEFP--ENFPPDAKDLIQKLLVLDPSKRLGVNEnggydeLKAHPF 277
STKc_TSSK4-like cd14162
Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs ...
128-409 6.73e-48

Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. It phosphorylates Cre-Responsive Element Binding protein (CREB), facilitating the binding of CREB to the specific cis cAMP responsive element (CRE), which is important in activating genes related to germ cell differentiation. Mutations in the human TSSK4 gene is associated with infertile Chinese men with impaired spermatogenesis. The TSSK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271064 [Multi-domain]  Cd Length: 259  Bit Score: 166.32  E-value: 6.73e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYgfprrppprgsqatqggpAKQLLPlervyQEIAILKKLD 207
Cdd:cd14162     2 YIVGKTLGHGSYAVVKKAYSTKHKCKVAIKIVSKKKAPEDY------------------LQKFLP-----REIEVIKGLK 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd14162    59 HPNLICFYEAIE--TTSRVYIIMELAENGDLLDyIRKNGALPEPQARRWFRQLVAGVEYCHSKGVVHRDLKCENLLLDKN 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 GHVKIADFGVS-NQFEGNDAQ--LSST-AGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLH 362
Cdd:cd14162   137 NNLKITDFGFArGVMKTKDGKpkLSETyCGSYAYASPEIL--RGIPYDPFLSDIWSMGVVLYTMVYGRLPFDDSNLKVLL 214
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1384865967 363 RKIKNEaVVFPEEPEVSEDLKDLILRMLDKNPEtRIGVSDIKLHPWV 409
Cdd:cd14162   215 KQVQRR-VVFPKNPTVSEECKDLILRMLSPVKK-RITIEEIKRDPWF 259
STKc_ATG1_ULK_like cd14009
Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like ...
134-408 7.06e-47

Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes yeast ATG1 and metazoan homologs including vertebrate ULK1-3. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. It is involved in nutrient sensing and signaling, the assembly of autophagy factors and the execution of autophagy. In metazoans, ATG1 homologs display additional functions. Unc-51 and ULKs have been implicated in neuronal and axonal development. The ATG1/ULK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270911 [Multi-domain]  Cd Length: 251  Bit Score: 163.16  E-value: 7.06e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrppprgsqatqggpaKQLLP--LERVYQEIAILKKLDHVNV 211
Cdd:cd14009     1 IGRGSFATVWKGRHKQTGEVVAIKEISR--------------------------KKLNKklQENLESEIAILKSIKHPNI 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 212 VKLIEVLDDPaeDNLYLvfdllrkgpVMEVpCD-----------KPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSN 280
Cdd:cd14009    55 VRLYDVQKTE--DFIYL---------VLEY-CAggdlsqyirkrGRLPEAVARHFMQQLASGLKFLRSKNIIHRDLKPQN 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 281 LLL---GDDGHVKIADFGVSNQFEGNDaqLSST-AGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDD 356
Cdd:cd14009   123 LLLstsGDDPVLKIADFGFARSLQPAS--MAETlCGSPLYMAPEIL--QFQKYDAKA-DLWSVGAILFEMLVGKPPFRGS 197
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 357 YILTLHRKIKNEAVV--FPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14009   198 NHVQLLRNIERSDAVipFPIAAQLSPDCKDLLRRLLRRDPAERISFEEFFAHPF 251
STKc_Kin1_2 cd14077
Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the ...
128-409 7.84e-47

Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of yeast Kin1, Kin2, and similar proteins. Fission yeast Kin1 is a membrane-associated kinase that is involved in regulating cell surface cohesiveness during interphase. It also plays a role during mitosis, linking actomyosin ring assembly with septum synthesis and membrane closure to ensure separation of daughter cells. Budding yeast Kin1 and Kin2 act downstream of the Rab-GTPase Sec4 and are associated with the exocytic apparatus; they play roles in the secretory pathway. The Kin1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270979 [Multi-domain]  Cd Length: 267  Bit Score: 163.77  E-value: 7.84e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPPPRGSQATQGGPAKQLLPLERVYQEIAILKKLD 207
Cdd:cd14077     3 WEFVKTIGAGSMGKVKLAKHIRTGEKCAIKI-----------IPRASNAGLKKEREKRLEKEISRDIRTIREAALSSLLN 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPAedNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd14077    72 HPHICRLRDFLRTPN--HYYMLFEYVDGGQLLDyIISHGKLKEKQARKFARQIASALDYLHRNSIVHRDLKIENILISKS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 GHVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIK 366
Cdd:cd14077   150 GNIKIIDFGLSNLYD-PRRLLRTFCGSLYFAAPELL--QAQPYTGPEVDVWSFGVVLYVLVCGKVPFDDENMPALHAKIK 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1384865967 367 NEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14077   227 KGKVEYPS--YLSSECKSLISRMLVVDPKKRATLEQVLNHPWM 267
STKc_PKA_like cd05580
Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs ...
126-408 8.27e-47

Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the cAMP-dependent protein kinases, PKA and PRKX, and similar proteins. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. PRKX is also reulated by the R subunit and is is present in many tissues including fetal and adult brain, kidney, and lung. It is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PKA-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270732 [Multi-domain]  Cd Length: 290  Bit Score: 164.29  E-value: 8.27e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQygfprrppprgsqatqggpaKQLlplERVYQEIAILKK 205
Cdd:cd05580     1 DDFEFLKTLGTGSFGRVRLVKHKDSGKYYALKILKKAKIIKL--------------------KQV---EHVLNEKRILSE 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDPaeDNLYLV---------FDLLRKGpvmevpcdKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd05580    58 VRHPFIVNLLGSFQDD--RNLYMVmeyvpggelFSLLRRS--------GRFPNDVAKFYAAEVVLALEYLHSLDIVYRDL 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLsstAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDD 356
Cdd:cd05580   128 KPENLLLDSDGHIKITDFGFAKRVKDRTYTL---CGTPEYLAPEIILSKGH---GKAVDWWALGILIYEMLAGYPPFFDE 201
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 357 YILTLHRKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIG-----VSDIKLHPW 408
Cdd:cd05580   202 NPMKIYEKILEGKIRFP--SFFDPDAKDLIKRLLVVDLTKRLGnlkngVEDIKNHPW 256
STKc_HAL4_like cd13994
Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs ...
134-409 3.50e-45

Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of HAL4, Saccharomyces cerevisiae Ptk2/Stk2, and similar fungal proteins. Proteins in this subfamily are involved in regulating ion transporters. In budding and fission yeast, HAL4 promotes potassium ion uptake, which increases cellular resistance to other cations such as sodium, lithium, and calcium ions. HAL4 stabilizes the major high-affinity K+ transporter Trk1 at the plasma membrane under low K+ conditions, which prevents endocytosis and vacuolar degradation. Budding yeast Ptk2 phosphorylates and regulates the plasma membrane H+ ATPase, Pma1. The HAL4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270896 [Multi-domain]  Cd Length: 265  Bit Score: 159.39  E-value: 3.50e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLA---YNESEDRhYAMKVlskkkllkqygFPRRPPPrgsqatqggpAKQLLPLERVYQEIAILKKLDHVN 210
Cdd:cd13994     1 IGKGATSVVRIVtkkNPRSGVL-YAVKE-----------YRRRDDE----------SKRKDYVKRLTSEYIISSKLHHPN 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 211 VVKLIEVLDDPAeDNLYLVFDLLRKG---PVMEVpcDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDG 287
Cdd:cd13994    59 IVKVLDLCQDLH-GKWCLVMEYCPGGdlfTLIEK--ADSLSLEEKDCFFKQILRGVAYLHSHGIAHRDLKPENILLDEDG 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 288 HVKIADFGVSNQFEGNDAQLSSTA----GTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPF----IDDYIL 359
Cdd:cd13994   136 VLKLTDFGTAEVFGMPAEKESPMSaglcGSEPYMAPEVF--TSGSYDGRAVDVWSCGIVLFALFTGRFPWrsakKSDSAY 213
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 360 TLHRKIKNEAVVFPEEPEVS--EDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd13994   214 KAYEKSGDFTNGPYEPIENLlpSECRRLIYRMLHPDPEKRITIDEALNDPWV 265
STKc_MELK cd14078
Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; ...
193-409 4.25e-45

Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MELK is a cell cycle dependent protein which functions in cytokinesis, cell cycle, apoptosis, cell proliferation, and mRNA processing. It is found upregulated in many types of cancer cells, playing an indispensable role in cancer cell survival. It makes an attractive target in the design of inhibitors for use in the treatment of a wide range of human cancer. The MELK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270980 [Multi-domain]  Cd Length: 257  Bit Score: 158.70  E-value: 4.25e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVME--VPCDKpFPEEQARLYLRDIILGLEYLHCQK 270
Cdd:cd14078    45 LPRVKTEIEALKNLSHQHICRLYHVIE--TDNKIFMVLEYCPGGELFDyiVAKDR-LSEDEARVFFRQIVSAVAYVHSQG 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGN-DAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYG 349
Cdd:cd14078   122 YAHRDLKPENLLLDEDQNLKLIDFGLCAKPKGGmDHHLETCCGSPAYAAPELI--QGKPYIGSEADVWSMGVLLYALLCG 199
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 350 KCPFIDDYILTLHRKIKNEAVvfpEEPE-VSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14078   200 FLPFDDDNVMALYRKIQSGKY---EEPEwLSPSSKLLLDQMLQVDPKKRITVKELLNHPWV 257
STKc_SIK cd14071
Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the ...
193-408 1.06e-44

Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SIKs are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells. In the brain, both SIK1 and SIK2 regulate energy metabolism. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein. The SIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270973 [Multi-domain]  Cd Length: 253  Bit Score: 157.55  E-value: 1.06e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDdpAEDNLYLV---------FDLLRKGPVMevpcdkpfPEEQARLYLRDIILGL 263
Cdd:cd14071    43 LKKIYREVQIMKMLNHPHIIKLYQVME--TKDMLYLVteyasngeiFDYLAQHGRM--------SEKEARKKFWQILSAV 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 264 EYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTL 343
Cdd:cd14071   113 EYCHKRHIVHRDLKAENLLLDANMNIKIADFGFSNFFK-PGELLKTWCGSPPYAAPEVF--EGKEYEGPQLDIWSLGVVL 189
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 344 YCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14071   190 YVLVCGALPFDGSTLQTLRDRVLSGRFRIPF--FMSTDCEHLIRRMLVLDPSKRLTIEQIKKHKW 252
STKc_CaMKII cd14086
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
126-409 2.67e-44

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. In addition, CaMKII contains a C-terminal association domain that facilitates oligomerization. There are four CaMKII proteins (alpha, beta, gamma, delta) encoded by different genes; each gene undergoes alternative splicing to produce more than 30 isoforms. CaMKII-alpha and -beta are enriched in neurons while CaMKII-gamma and -delta are predominant in myocardium. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. It is a major component of the postsynaptic density and is critical in regulating synaptic plasticity including long-term potentiation. It is critical in regulating ion channels and proteins involved in myocardial excitation-contraction and excitation-transcription coupling. Excessive CaMKII activity promotes processes that contribute to heart failure and arrhythmias. The CaMKII subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270988 [Multi-domain]  Cd Length: 292  Bit Score: 157.97  E-value: 2.67e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrppprgsqATQGGPAKQLLPLERvyqEIAILKK 205
Cdd:cd14086     1 DEYDLKEELGKGAFSVVRRCVQKSTGQEFAAKII---------------------NTKKLSARDHQKLER---EARICRL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14086    57 LKHPNIVRLHDSISE--EGFHYLVFDLVTGGELFEdIVAREFYSEADASHCIQQILESVNHCHQNGIVHRDLKPENLLLA 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 D---DGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTL 361
Cdd:cd14086   135 SkskGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPY---GKPVDIWACGVILYILLVGYPPFWDEDQHRL 211
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 362 HRKIKNEAVVFPeEPE---VSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14086   212 YAQIKAGAYDYP-SPEwdtVTPEAKDLINQMLTVNPAKRITAAEALKHPWI 261
STKc_STK36 cd14002
Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the ...
183-409 3.54e-44

Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK36, also called Fused (or Fu) kinase, is involved in the Hedgehog signaling pathway. It is activated by the Smoothened (SMO) signal transducer, resulting in the stabilization of GLI transcription factors and the phosphorylation of SUFU to facilitate the nuclear accumulation of GLI. In Drosophila, Fused kinase is maternally required for proper segmentation during embryonic development and for the development of legs and wings during the larval stage. In mice, STK36 is not necessary for embryonic development, although mice deficient in STK36 display growth retardation postnatally. The STK36 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270904 [Multi-domain]  Cd Length: 253  Bit Score: 156.26  E-value: 3.54e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 183 QGGPAKQLLPLErvyQEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRkGPVMEV-PCDKPFPEEQARLYLRDIIL 261
Cdd:cd14002    37 RGKSEKELRNLR---QEIEILRKLNHPNIIEMLDSFETKKE--FVVVTEYAQ-GELFQIlEDDGTLPEEEVRSIAKQLVS 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDsgQSFSGKAlDVWATGV 341
Cdd:cd14002   111 ALHYLHSNRIIHRDMKPQNILIGKGGVVKLCDFGFARAMSCNTLVLTSIKGTPLYMAPELVQE--QPYDHTA-DLWSLGC 187
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 342 TLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14002   188 ILYELFVGQPPFYTNSIYQLVQMIVKDPVKWPS--NMSPEFKSFLQGLLNKDPSKRLSWPDLLEHPFV 253
STKc_MAP3K-like cd13999
Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine ...
193-397 7.19e-44

Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.


Pssm-ID: 270901 [Multi-domain]  Cd Length: 245  Bit Score: 155.00  E-value: 7.19e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPaeDNLYLV---------FDLLRKGpvmevpcDKPFPEEQARLYLRDIILGL 263
Cdd:cd13999    34 LKEFRREVSILSKLRHPNIVQFIGACLSP--PPLCIVteympggslYDLLHKK-------KIPLSWSLRLKIALDIARGM 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 264 EYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTL 343
Cdd:cd13999   105 NYLHSPPIIHRDLKSLNILLDENFTVKIADFGLSRIKNSTTEKMTGVVGTPRWMAPEVL--RGEPYTEKA-DVYSFGIVL 181
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 344 YCFVYGKCPFidDYILTLHrkiKNEAVVF-PEEPEV----SEDLKDLILRMLDKNPETR 397
Cdd:cd13999   182 WELLTGEVPF--KELSPIQ---IAAAVVQkGLRPPIppdcPPELSKLIKRCWNEDPEKR 235
STKc_phototropin_like cd05574
Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
193-408 1.37e-43

Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phototropins are blue-light receptors that control responses such as phototropism, stromatal opening, and chloroplast movement in order to optimize the photosynthetic efficiency of plants. They are light-activated STKs that contain an N-terminal photosensory domain and a C-terminal catalytic domain. The N-terminal domain contains two LOV (Light, Oxygen or Voltage) domains that binds FMN. Photoexcitation of the LOV domains results in autophosphorylation at multiple sites and activation of the catalytic domain. In addition to plant phototropins, included in this subfamily are predominantly uncharacterized fungal STKs whose catalytic domains resemble the phototropin kinase domain. One protein from Neurospora crassa is called nrc-2, which plays a role in growth and development by controlling entry into the conidiation program. The phototropin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270726 [Multi-domain]  Cd Length: 316  Bit Score: 156.63  E-value: 1.37e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDdpAEDNLYLV---------FDLLRKGPvmevpcDKPFPEEQARLYLRDIILGL 263
Cdd:cd05574    45 VKRVLTEREILATLDHPFLPTLYASFQ--TSTHLCFVmdycpggelFRLLQKQP------GKRLPEEVARFYAAEVLLAL 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 264 EYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ----------------FEGNDAQLS-------------STAGTP 314
Cdd:cd05574   117 EYLHLLGFVYRDLKPENILLHESGHIMLTDFDLSKQssvtpppvrkslrkgsRRSSVKSIEketfvaepsarsnSFVGTE 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 315 AFMAPEAISDSGQSFsgkALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNP 394
Cdd:cd05574   197 EYIAPEVIKGDGHGS---AVDWWTLGILLYEMLYGTTPFKGSNRDETFSNILKKELTFPESPPVSSEAKDLIRKLLVKDP 273
                         250
                  ....*....|....*...
gi 1384865967 395 ETRI----GVSDIKLHPW 408
Cdd:cd05574   274 SKRLgskrGASEIKRHPF 291
STKc_NDR_like cd05599
Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs ...
134-408 1.41e-43

Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR kinases regulate mitosis, cell growth, embryonic development, and neurological processes. They are also required for proper centrosome duplication. Higher eukaryotes contain two NDR isoforms, NDR1 and NDR2. This subfamily also contains fungal NDR-like kinases. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270750 [Multi-domain]  Cd Length: 324  Bit Score: 156.62  E-value: 1.41e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLLP---LER-----VYQEIAILKK 205
Cdd:cd05599     9 IGRGAFGEVRLVRKKDTGHVYAM-------------------------------KKLRKsemLEKeqvahVRAERDILAE 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd05599    58 ADNPWVVKLYYSFQD--EENLYLIMEFLPGGDMMTLLMKKDtLTEEETRFYIAETVLAIESIHKLGYIHRDIKPDNLLLD 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQFEGndAQLS-STAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHR 363
Cdd:cd05599   136 ARGHIKLSDFGLCTGLKK--SHLAySTVGTPDYIAPEVFLQKGY---GKECDWWSLGVIMYEMLIGYPPFCSDDPQETCR 210
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384865967 364 KIKN--EAVVFPEEPEVSEDLKDLILRMLdKNPETRIG---VSDIKLHPW 408
Cdd:cd05599   211 KIMNwrETLVFPPEVPISPEAKDLIERLL-CDAEHRLGangVEEIKSHPF 259
STKc_ROCK_NDR_like cd05573
Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear ...
126-408 1.73e-43

Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear Dbf2-Related (NDR)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include ROCK and ROCK-like proteins such as DMPK, MRCK, and CRIK, as well as NDR and NDR-like proteins such as LATS, CBK1 and Sid2p. ROCK and CRIK are effectors of the small GTPase Rho, while MRCK is an effector of the small GTPase Cdc42. NDR and NDR-like kinases contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Proteins in this subfamily are involved in regulating many cellular functions including contraction, motility, division, proliferation, apoptosis, morphogenesis, and cytokinesis. The ROCK/NDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270725 [Multi-domain]  Cd Length: 350  Bit Score: 157.06  E-value: 1.73e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQL---LPLER-----VY 197
Cdd:cd05573     1 DDFEVIKVIGRGAFGEVWLVRDKDTGQVYAM-------------------------------KILrksDMLKReqiahVR 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd05573    50 AERDILADADSPWIVRLHYAFQD--EDHLYLVMEYMPGGDLMNLLIKYDvFPEETARFYIAELVLALDSLHKLGFIHRDI 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLS-----------------------------STAGTPAFMAPEAISdsGQ 327
Cdd:cd05573   128 KPDNILLDADGHIKLADFGLCTKMNKSGDRESylndsvntlfqdnvlarrrphkqrrvraySAVGTPDYIAPEVLR--GT 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 328 SFsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKN--EAVVFPEEPEVSEDLKDLILRMLdKNPETRIG-VSDIK 404
Cdd:cd05573   206 GY-GPECDWWSLGVILYEMLYGFPPFYSDSLVETYSKIMNwkESLVFPDDPDVSPEAIDLIRRLL-CDPEDRLGsAEEIK 283

                  ....
gi 1384865967 405 LHPW 408
Cdd:cd05573   284 AHPF 287
STKc_DCKL cd14095
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called ...
128-408 2.09e-43

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL (or DCAMKL) proteins belong to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL proteins contain a C-terminal kinase domain with similarity to CAMKs. They are involved in the regulation of cAMP signaling. Vertebrates contain three DCKL proteins (DCKL1-3); DCKL1 and 2 also contain a serine, threonine, and proline rich domain (SP), while DCKL3 contains only a single DCX domain instead of tandem domains. The DCKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270997 [Multi-domain]  Cd Length: 258  Bit Score: 154.41  E-value: 2.09e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygfprRPPPRGsqatqggpaKQLLplerVYQEIAILKKLD 207
Cdd:cd14095     2 YDIGRVIGDGNFAVVKECRDKATDKEYALKIID------------KAKCKG---------KEHM----IENEVAILRRVK 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd14095    57 HPNIVQLIEEYDTD--TELYLVMELVKGGDLFDaITSSTKFTERDASRMVTDLAQALKYLHSLSIVHRDIKPENLLVVEH 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 G----HVKIADFGVSNQFEGndaQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFI--DDYILT 360
Cdd:cd14095   135 EdgskSLKLADFGLATEVKE---PLFTVCGTPTYVAPEILAETGY---GLKVDIWAAGVITYILLCGFPPFRspDRDQEE 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 361 LHRKIKNEAVVFPeEP---EVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14095   209 LFDLILAGEFEFL-SPywdNISDSAKDLISRMLVVDPEKRYSAGQVLDHPW 258
STKc_CDK_like cd07829
Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs ...
128-408 2.96e-43

Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDKs are partly regulated by their subcellular localization, which defines substrate phosphorylation and the resulting specific function. CDK1, CDK2, CDK4, and CDK6 have well-defined functions in the cell cycle, such as the regulation of the early G1 phase by CDK4 or CDK6, the G1/S phase transition by CDK2, or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes, showing that some CDKs can compensate for each other. For example, CDK4 can compensate for the loss of CDK6, however, double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270823 [Multi-domain]  Cd Length: 282  Bit Score: 154.56  E-value: 2.96e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLlpleRvyqEIAILKKLD 207
Cdd:cd07829     1 YEKLEKLGEGTYGVVYKAKDKKTGEIVALKKI-----------------RLDNEEEGIPSTAL----R---EISLLKELK 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLddPAEDNLYLVFDL----LRKgpVMEVpCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd07829    57 HPNIVKLLDVI--HTENKLYLVFEYcdqdLKK--YLDK-RPGPLPPNLIKSIMYQLLRGLAYCHSHRILHRDLKPQNLLI 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 GDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFI-DDYILTLH 362
Cdd:cd07829   132 NRDGVLKLADFGLARAFGIPLRTYTHEVVTLWYRAPEIL--LGSKHYSTAVDIWSVGCIFAELITGKPLFPgDSEIDQLF 209
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 363 R-----------------KIKNEAVVFPE---------EPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd07829   210 KifqilgtpteeswpgvtKLPDYKPTFPKwpkndlekvLPRLDPEGIDLLSKMLQYNPAKRISAKEALKHPY 281
STKc_MST3_like cd06609
Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs ...
126-414 1.02e-42

Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST3, MST4, STK25, Schizosaccharomyces pombe Nak1 and Sid1, Saccharomyces cerevisiae sporulation-specific protein 1 (SPS1), and related proteins. Nak1 is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Sid1 is a component in the septation initiation network (SIN) signaling pathway, and plays a role in cytokinesis. SPS1 plays a role in regulating proteins required for spore wall formation. MST4 plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. STK25 may play a role in the regulation of cell migration and polarization. The MST3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270786 [Multi-domain]  Cd Length: 274  Bit Score: 152.78  E-value: 1.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQL-L-----PLERVYQE 199
Cdd:cd06609     1 ELFTLLERIGKGSFGEVYKGIDKRTNQVVAI-------------------------------KVIdLeeaedEIEDIQQE 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 200 IAILKKLDHVNVVKLIE-VLDDpaeDNLYLV---------FDLLRKGPvmevpcdkpFPEEQARLYLRDIILGLEYLHCQ 269
Cdd:cd06609    50 IQFLSQCDSPYITKYYGsFLKG---SKLWIImeycgggsvLDLLKPGP---------LDETYIAFILREVLLGLEYLHSE 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 270 KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGqsFSGKAlDVWATGVTLYCFVYG 349
Cdd:cd06609   118 GKIHRDIKAANILLSEEGDVKLADFGVSGQLTSTMSKRNTFVGTPFWMAPEVIKQSG--YDEKA-DIWSLGITAIELAKG 194
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 350 KCPFIDDYILTLHRKI-KNEAvvfP--EEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGE 414
Cdd:cd06609   195 EPPLSDLHPMRVLFLIpKNNP---PslEGNKFSKPFKDFVELCLNKDPKERPSAKELLKHKFIKKAKK 259
STKc_Rad53_Cds1 cd14098
Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the ...
193-408 1.04e-42

Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Rad53 and Cds1 are the checkpoint kinase 2 (Chk2) homologs found in budding and fission yeast, respectively. They play a central role in the cell's response to DNA lesions to prevent genome rearrangements and maintain genome integrity. They are phosphorylated in response to DNA damage and incomplete replication, and are essential for checkpoint control. They help promote DNA repair by stalling the cell cycle prior to mitosis in the presence of DNA damage. The Rad53/Cds1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271000 [Multi-domain]  Cd Length: 265  Bit Score: 152.63  E-value: 1.04e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd14098    45 LQLFQREINILKSLEHPGIVRLIDWYEDD--QHIYLVMEYVEGGDLMDFIMAWgAIPEQHARELTKQILEAMAYTHSMGI 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDG--HVKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSG---KALDVWATGVTLYCF 346
Cdd:cd14098   123 THRDLKPENILITQDDpvIVKISDFGLA-KVIHTGTFLVTFCGTMAYLAPEILMSKEQNLQGgysNLVDMWSVGCLVYVM 201
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 347 VYGKCPFIDDYILTLHRKIKNEAvvFPEEP----EVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14098   202 LTGALPFDGSSQLPVEKRIRKGR--YTQPPlvdfNISEEAIDFILRLLDVDPEKRMTAAQALDHPW 265
STKc_PhKG cd14093
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs ...
193-408 1.61e-42

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). Each subunit has tissue-specific isoforms or splice variants. Vertebrates contain two isoforms of the gamma subunit (gamma 1 and gamma 2). The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270995 [Multi-domain]  Cd Length: 272  Bit Score: 152.51  E-value: 1.61e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLD-HVNVVKLIEVLDDPAedNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQK 270
Cdd:cd14093    52 REATRREIEILRQVSgHPNIIELHDVFESPT--FIFLVFELCRKGELFDYLTEVvTLSEKKTRRIMRQLFEAVEFLHSLN 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAISDS---GQSFSGKALDVWATGVTLYCFV 347
Cdd:cd14093   130 IVHRDLKPENILLDDNLNVKISDFGFATRLDEGE-KLRELCGTPGYLAPEVLKCSmydNAPGYGKEVDMWACGVIMYTLL 208
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 348 YGKCPFIDDYILTLHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14093   209 AGCPPFWHRKQMVMLRNIMEGKYEFgsPEWDDISDTAKDLISKLLVVDPKKRLTAEEALEHPF 271
Pkinase pfam00069
Protein kinase domain;
128-409 1.98e-42

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 150.47  E-value: 1.98e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYgfprrppprgsqatqggpakqllpLERVYQEIAILKKLD 207
Cdd:pfam00069   1 YEVLRKLGSGSFGTVYKAKHRDTGKIVAIKKIKKEKIKKKK------------------------DKNILREIKILKKLN 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEylhcqkivhrdikpsnlllgdd 286
Cdd:pfam00069  57 HPNIVRLYDAFEDK--DNLYLVLEYVEGGSLFDlLSEKGAFSEREAKFIMKQILEGLE---------------------- 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 ghvkiadfgvsnqfegNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIK 366
Cdd:pfam00069 113 ----------------SGSSLTTFVGTPWYMAPEVLGGNPY---GPKVDVWSLGCILYELLTGKPPFPGINGNEIYELII 173
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 367 NEAVVFPEEP-EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:pfam00069 174 DQPYAFPELPsNLSEEAKDLLKKLLKKDPSKRLTATQALQHPWF 217
STKc_NUAK cd14073
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze ...
127-409 2.82e-42

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK1, also called ARK5 (AMPK-related protein kinase 5), regulates cell proliferation and displays tumor suppression through direct interaction and phosphorylation of p53. It is also involved in cell senescence and motility. High NUAK1 expression is associated with invasiveness of nonsmall cell lung cancer (NSCLC) and breast cancer cells. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. The NUAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270975 [Multi-domain]  Cd Length: 254  Bit Score: 151.00  E-value: 2.82e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsQATQGGPAKQLLPLERVYQEIAILKKL 206
Cdd:cd14073     2 RYELLETLGKGTYGKVKLAIERATGREVAI-----------------------KSIKKDKIEDEQDMVRIRREIEIMSSL 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGD 285
Cdd:cd14073    59 NHPHIIRIYEVFEN--KDKIVIVMEYASGGELYDyISERRRLPEREARRIFRQIVSAVHYCHKNGVVHRDLKLENILLDQ 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKI 365
Cdd:cd14073   137 NGNAKIADFGLSNLYSKDKL-LQTFCGSPLYASPEIV--NGTPYQGPEVDCWSLGVLLYTLVYGTMPFDGSDFKRLVKQI 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 366 KNEAVVFPEEPevsEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14073   214 SSGDYREPTQP---SDASGLIRWMLTVNPKRRATIEDIANHWWV 254
STKc_Chk1 cd14069
Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the ...
126-409 3.20e-42

Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chk1 is implicated in many major checkpoints of the cell cycle, providing a link between upstream sensors and the cell cycle engine. It plays an important role in DNA damage response and maintaining genomic stability. Chk1 acts as an effector of the sensor kinase, ATR (ATM and Rad3-related), a member of the PI3K family, which is activated upon DNA replication stress. Chk1 delays mitotic entry in response to replication blocks by inhibiting cyclin dependent kinase (Cdk) activity. In addition, Chk1 contributes to the function of centrosome and spindle-based checkpoints, inhibits firing of origins of DNA replication (Ori), and represses transcription of cell cycle proteins including cyclin B and Cdk1. The Chk1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270971 [Multi-domain]  Cd Length: 261  Bit Score: 151.33  E-value: 3.20e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKkllkqygfprrppprgsqatqggPAKQLLPlERVYQEIAILKK 205
Cdd:cd14069     1 EDWDLVQTLGEGAFGEVFLAVNRNTEEAVAVKFVDMK-----------------------RAPGDCP-ENIKKEVCIQKM 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDPAedNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14069    57 LSHKNVVRFYGHRREGE--FQYLFLEYASGGELFDkIEPDVGMPEDVAQFYFQQLMAGLKYLHSCGITHRDIKPENLLLD 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQFEGNDAQ--LSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCP---------- 352
Cdd:cd14069   135 ENDNLKISDFGLATVFRYKGKErlLNKMCGTLPYVAPELL--AKKKYRAEPVDVWSCGIVLFAMLAGELPwdqpsdscqe 212
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 353 ---FIDDYILTLH--RKIKNEAVvfpeepevsedlkDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14069   213 ysdWKENKKTYLTpwKKIDTAAL-------------SLLRKILTENPNKRITIEDIKKHPWY 261
STKc_MEKK1_plant cd06632
Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP) ...
134-409 4.23e-42

Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of plant MAPK kinase kinases (MAPKKKs) including Arabidopsis thaliana MEKK1 and MAPKKK3. Arabidopsis thaliana MEKK1 activates MPK4, a MAPK that regulates systemic acquired resistance. MEKK1 also participates in the regulation of temperature-sensitive and tissue-specific cell death. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The plant MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270802 [Multi-domain]  Cd Length: 259  Bit Score: 151.02  E-value: 4.23e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrppPRGSQATQGGPA-KQLlplervYQEIAILKKLDHVNVV 212
Cdd:cd06632     8 LGSGSFGSVYEGFNGDTGDFFAVKEV----------------SLVDDDKKSRESvKQL------EQEIALLSKLRHPNIV 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 213 KLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCD-KPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKI 291
Cdd:cd06632    66 QYYGTERE--EDNLYIFLEYVPGGSIHKLLQRyGAFEEPVIRLYTRQILSGLAYLHSRNTVHRDIKGANILVDTNGVVKL 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 292 ADFGVSNQFEGNDaQLSSTAGTPAFMAPEAIsDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVV 371
Cdd:cd06632   144 ADFGMAKHVEAFS-FAKSFKGSPYWMAPEVI-MQKNSGYGLAVDIWSLGCTVLEMATGKPPWSQYEGVAAIFKIGNSGEL 221
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1384865967 372 fPEEPE-VSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06632   222 -PPIPDhLSPDAKDFIRLCLQRDPEDRPTASQLLEHPFV 259
PKc_MAPKK_plant_like cd06623
Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and ...
132-412 7.86e-42

Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include MAPKKs from plants, kinetoplastids, alveolates, and mycetozoa. The MAPKK, LmxPK4, from Leishmania mexicana, is important in differentiation and virulence. Dictyostelium discoideum MEK1 is required for proper chemotaxis; MEK1 null mutants display severe defects in cell polarization and directional movement. Plants contain multiple MAPKKs like other eukaryotes. The Arabidopsis genome encodes for 10 MAPKKs while poplar and rice contain 13 MAPKKs each. The functions of these proteins have not been fully elucidated. There is evidence to suggest that MAPK cascades are involved in plant stress responses. In Arabidopsis, MKK3 plays a role in pathogen signaling; MKK2 is involved in cold and salt stress signaling; MKK4/MKK5 participates in innate immunity; and MKK7 regulates basal and systemic acquired resistance. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132954 [Multi-domain]  Cd Length: 264  Bit Score: 150.43  E-value: 7.86e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 132 SEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygFPRRPPPRgsqatqggpaKQLLplervyQEIAILKKLDHVNV 211
Cdd:cd06623     7 KVLGQGSSGVVYKVRHKPTGKIYALKKIH---------VDGDEEFR----------KQLL------RELKTLRSCESPYV 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 212 VKLIEVLDDPAEdnLYLVF---------DLLRKgpvmevpcDKPFPEEQARLYLRDIILGLEYLHCQ-KIVHRDIKPSNL 281
Cdd:cd06623    62 VKCYGAFYKEGE--ISIVLeymdggslaDLLKK--------VGKIPEPVLAYIARQILKGLDYLHTKrHIIHRDIKPSNL 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 282 LLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFID----DY 357
Cdd:cd06623   132 LINSKGEVKIADFGISKVLENTLDQCNTFVGTVTYMSPERI--QGESYSYAA-DIWSLGLTLLECALGKFPFLPpgqpSF 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 358 IlTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKH 412
Cdd:cd06623   209 F-ELMQAICDGPPPSLPAEEFSPEFRDFISACLQKDPKKRPSAAELLQHPFIKKA 262
STKc_SNRK cd14074
Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the ...
196-409 1.00e-41

Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SNRK is a kinase highly expressed in testis and brain that is found inactive in cells that lack the LKB1 tumour suppressor protein kinase. The regulatory subunits STRAD and MO25 are required for LKB1 to activate SNRK. The SNRK mRNA is increased 3-fold when granule neurons are cultured in low potassium, and may thus play a role in the survival responses in these cells. In some vertebrates, a second SNRK gene (snrkb or snrk-1) has been sequenced and/or identified. Snrk-1 is expressed specifically in embryonic zebrafish vasculature; it plays an essential role in angioblast differentiation, maintenance, and migration. The SNRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270976 [Multi-domain]  Cd Length: 258  Bit Score: 149.87  E-value: 1.00e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 196 VYQEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVME--VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:cd14074    49 LFQEVRCMKLVQHPNVVRLYEVIDTQTK--LYLILELGDGGDMYDyiMKHENGLNEDLARKYFRQIVSAISYCHKLHVVH 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLL-GDDGHVKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCP 352
Cdd:cd14074   127 RDLKPENVVFfEKQGLVKLTDFGFSNKFQPGE-KLETSCGSLAYSAPEIL--LGDEYDAPAVDIWSLGVILYMLVCGQPP 203
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 353 FI---DDYILTlhrKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14074   204 FQeanDSETLT---MIMDCKYTVP--AHVSPECKDLIRRMLIRDPKKRASLEEIENHPWL 258
STKc_cGK cd05572
Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); ...
134-408 1.28e-41

Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mammals have two cGK isoforms from different genes, cGKI and cGKII. cGKI exists as two splice variants, cGKI-alpha and cGKI-beta. cGK consists of an N-terminal regulatory domain containing a dimerization and an autoinhibitory pseudosubstrate region, two cGMP-binding domains, and a C-terminal catalytic domain. Binding of cGMP to both binding sites releases the inhibition of the catalytic center by the pseudosubstrate region, allowing autophosphorylation and activation of the kinase. cGKI is a soluble protein expressed in all smooth muscles, platelets, cerebellum, and kidney. It is also expressed at lower concentrations in other tissues. cGKII is a membrane-bound protein that is most abundantly expressed in the intestine. It is also present in the brain nuclei, adrenal cortex, kidney, lung, and prostate. cGKI is involved in the regulation of smooth muscle tone, smooth cell proliferation, and platelet activation. cGKII plays a role in the regulation of secretion, such as renin secretion by the kidney and aldosterone secretion by the adrenal. It also regulates bone growth and the circadian rhythm. The cGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270724 [Multi-domain]  Cd Length: 262  Bit Score: 149.68  E-value: 1.28e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQllplerVYQEIAILKKLDHVNVVK 213
Cdd:cd05572     1 LGVGGFGRVELVQLKSKGRTFALKCV-----------------KKRHIVQTRQQEH------IFSEKEILEECNSPFIVK 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd05572    58 LYRTFKD--KKYLYMLMEYCLGGELWTILRDRgLFDEYTARFYTACVVLAFEYLHSRGIIYRDLKPENLLLDSNGYVKLV 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGVSNQFeGNDAQLSSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCPF--IDDYILTLHRKI--KNE 368
Cdd:cd05572   136 DFGFAKKL-GSGRKTWTFCGTPEYVAPEIILNKGYDFS---VDYWSLGILLYELLTGRPPFggDDEDPMKIYNIIlkGID 211
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1384865967 369 AVVFPeePEVSEDLKDLILRMLDKNPETRIG-----VSDIKLHPW 408
Cdd:cd05572   212 KIEFP--KYIDKNAKNLIKQLLRRNPEERLGylkggIRDIKKHKW 254
STKc_CaMKI cd14083
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
199-408 4.95e-40

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270985 [Multi-domain]  Cd Length: 259  Bit Score: 145.21  E-value: 4.95e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPAedNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd14083    51 EIAVLRKIKHPNIVQLLDIYESKS--HLYLVMELVTGGELFDRIVEKgSYTEKDASHLIRQVLEAVDYLHSLGIVHRDLK 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 278 PSNLL---LGDDGHVKIADFGVSnQFEGNdAQLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATGVTLYCFVYGKCPFI 354
Cdd:cd14083   129 PENLLyysPDEDSKIMISDFGLS-KMEDS-GVMSTACGTPGYVAPEVLA---QKPYGKAVDCWSIGVISYILLCGYPPFY 203
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 355 DDYILTLHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14083   204 DENDSKLFAQILKAEYEFdsPYWDDISDSAKDFIRHLMEKDPNKRYTCEQALEHPW 259
STKc_ULK3 cd14121
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the ...
194-408 3.20e-39

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK3 mRNA is up-regulated in fibroblasts after Ras-induced senescence, and its overexpression induces both autophagy and senescence in a fibroblast cell line. ULK3, through its kinase activity, positively regulates Gli proteins, mediators of the Sonic hedgehog (Shh) signaling pathway that is implicated in tissue homeostasis maintenance and neurogenesis. It is inhibited by binding to Suppressor of Fused (Sufu). The ULK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271023 [Multi-domain]  Cd Length: 252  Bit Score: 142.81  E-value: 3.20e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVfdllrkgpvMEVpCD-----------KPFPEEQARLYLRDIILG 262
Cdd:cd14121    40 ENLLTEIELLKKLKHPHIVELKDFQWD--EEHIYLI---------MEY-CSggdlsrfirsrRTLPESTVRRFLQQLASA 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYLHCQKIVHRDIKPSNLLL--GDDGHVKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATG 340
Cdd:cd14121   108 LQFLREHNISHMDLKPQNLLLssRYNPVLKLADFGFA-QHLKPNDEAHSLRGSPLYMAPEMI--LKKKYDARV-DLWSVG 183
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 341 VTLYCFVYGKCPFIDDYILTLHRKIK-NEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14121   184 VILYECLFGRAPFASRSFEELEEKIRsSKPIEIPTRPELSADCRDLLLRLLQRDPDRRISFEEFFAHPF 252
STKc_TSSK1_2-like cd14165
Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; ...
128-408 4.66e-39

Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK2 is localized in the sperm neck, equatorial segment, and mid-piece of the sperm tail. Both TSSK1 and TSSK2 phosphorylate their common substrate TSKS (testis-specific-kinase-substrate). TSSK1/TSSK2 double knock-out mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271067 [Multi-domain]  Cd Length: 263  Bit Score: 143.00  E-value: 4.66e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPPPRGSqatqggpAKQLLPlervyQEIAILKKLD 207
Cdd:cd14165     3 YILGINLGEGSYAKVKSAYSERLKCNVAIKI-----------IDKKKAPDDF-------VEKFLP-----RELEILARLN 59
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDdPAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd14165    60 HKSIIKTYEIFE-TSDGKVYIVMELGVQGDLLEfIKLRGALPEDVARKMFHQLSSAIKYCHELDIVHRDLKCENLLLDKD 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 GHVKIADFGVSNQFEGND---AQLSST-AGTPAFMAPEAISdsGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLH 362
Cdd:cd14165   139 FNIKLTDFGFSKRCLRDEngrIVLSKTfCGSAAYAAPEVLQ--GIPYDPRIYDIWSLGVILYIMVCGSMPYDDSNVKKML 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1384865967 363 RKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14165   217 KIQKEHRVRFPRSKNLTSECKDLIYRLLQPDVSQRLCIDEVLSHPW 262
STKc_CMGC cd05118
Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
128-408 7.12e-39

Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs), Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs), c-Jun N-terminal kinases (JNKs), and p38, and other kinases. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Other members of the CMGC family include casein kinase 2 (CK2), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK), Glycogen Synthase Kinase 3 (GSK3), among many others. The CMGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270688 [Multi-domain]  Cd Length: 249  Bit Score: 141.99  E-value: 7.12e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprRPPPRGSQATqggpakqllplervYQEIAILKKL- 206
Cdd:cd05118     1 YEVLRKIGEGAFGTVWLARDKVTGEKVAIKKI-------------KNDFRHPKAA--------------LREIKLLKHLn 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 ---DHVNVVKLIEVLDDPAEDNLYLVFDLL--------RKGPvmevpcdKPFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd05118    54 dveGHPNIVKLLDVFEHRGGNHLCLVFELMgmnlyeliKDYP-------RGLPLDLIKSYLYQLLQALDFLHSNGIIHRD 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLL-GDDGHVKIADFGVSNQFegNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKcPF- 353
Cdd:cd05118   127 LKPENILInLELGQLKLADFGLARSF--TSPPYTPYVATRWYRAPEVL--LGAKPYGSSIDIWSLGCILAELLTGR-PLf 201
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 354 -IDDYILTLHRKIKneaVVFPEEpevsedLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd05118   202 pGDSEVDQLAKIVR---LLGTPE------ALDLLSKMLKYDPAKRITASQALAHPY 248
STKc_PAK cd06614
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the ...
193-407 1.37e-38

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. PAK deregulation is associated with tumor development. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). Group II PAKs contain a PBD and a catalytic domain, but lack other motifs found in group I PAKs. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. Group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX; no such binding has been demonstrated for group II PAKs. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270789 [Multi-domain]  Cd Length: 255  Bit Score: 141.19  E-value: 1.37e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIE-VLDDpaeDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQ 269
Cdd:cd06614    40 KELIINEILIMKECKHPNIVDYYDsYLVG---DELWVVMEYMDGGSLTDIitQNPVRMNESQIAYVCREVLQGLEYLHSQ 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 270 KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYG 349
Cdd:cd06614   117 NVIHRDIKSDNILLSKDGSVKLADFGFAAQLTKEKSKRNSVVGTPYWMAPEVI--KRKDYGPKV-DIWSLGIMCIEMAEG 193
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 350 KCPFIDDYILTLHRKIKNEAVVFPEEPE-VSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd06614   194 EPPYLEEPPLRALFLITTKGIPPLKNPEkWSPEFKDFLNKCLVKDPEKRPSAEELLQHP 252
STKc_PKC cd05570
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer ...
223-407 1.72e-38

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, classical PKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. Novel PKCs are calcium-independent, but require DAG and PS for activity, while atypical PKCs only require PS. PKCs phosphorylate and modify the activities of a wide variety of cellular proteins including receptors, enzymes, cytoskeletal proteins, transcription factors, and other kinases. They play a central role in signal transduction pathways that regulate cell migration and polarity, proliferation, differentiation, and apoptosis. Also included in this subfamily are the PKC-like proteins, called PKNs. The PKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270722 [Multi-domain]  Cd Length: 318  Bit Score: 142.74  E-value: 1.72e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS--NQ 299
Cdd:cd05570    68 EDRLYFVMEYVNGGDLMfHIQRARRFTEERARFYAAEICLALQFLHERGIIYRDLKLDNVLLDAEGHIKIADFGMCkeGI 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 300 FEGNdaqLSST-AGTPAFMAPEAIsdSGQSFsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPeePEV 378
Cdd:cd05570   148 WGGN---TTSTfCGTPDYIAPEIL--REQDY-GFSVDWWALGVLLYEMLAGQSPFEGDDEDELFEAILNDEVLYP--RWL 219
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1384865967 379 SEDLKDLILRMLDKNPETRIGV-----SDIKLHP 407
Cdd:cd05570   220 SREAVSILKGLLTKDPARRLGCgpkgeADIKAHP 253
STKc_MARK cd14072
Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; ...
127-409 1.77e-38

Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MARKs, also called Partitioning-defective 1 (Par1) proteins, function as regulators of diverse cellular processes in nematodes, Drosophila, yeast, and vertebrates. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. Vertebrates contain four isoforms, namely MARK1 (or Par1c), MARK2 (or Par1b), MARK3 (Par1a), and MARK4 (or MARKL1). Known substrates of MARKs include the cell cycle-regulating phosphatase Cdc25, tyrosine phosphatase PTPH1, MAPK scaffolding protein KSR1, class IIa histone deacetylases, and plakophilin 2. The MARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270974 [Multi-domain]  Cd Length: 253  Bit Score: 141.12  E-value: 1.77e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAynesedRHYamkvlskkkllkqygfprrppPRGSQ-ATQGGPAKQLLP--LERVYQEIAIL 203
Cdd:cd14072     1 NYRLLKTIGKGNFAKVKLA------RHV---------------------LTGREvAIKIIDKTQLNPssLQKLFREVRIM 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 204 KKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:cd14072    54 KILNHPNIVKLFEVIE--TEKTLYLVMEYASGGEVFDyLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAENLL 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 LGDDGHVKIADFGVSNQFE-GNdaQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTL 361
Cdd:cd14072   132 LDADMNIKIADFGFSNEFTpGN--KLDTFCGSPPYAAPELF--QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKEL 207
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 362 HRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14072   208 RERVLRGKYRIPF--YMSTDCENLLKKFLVLNPSKRGTLEQIMKDRWM 253
PTZ00263 PTZ00263
protein kinase A catalytic subunit; Provisional
124-408 2.37e-38

protein kinase A catalytic subunit; Provisional


Pssm-ID: 140289 [Multi-domain]  Cd Length: 329  Bit Score: 142.65  E-value: 2.37e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 124 QLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPPPRGSQatqggpakqllpLERVYQEIAIL 203
Cdd:PTZ00263   16 KLSDFEMGETLGTGSFGRVRIAKHKGTGEYYAIKC-----------LKKREILKMKQ------------VQHVAQEKSIL 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 204 KKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:PTZ00263   73 MELSHPFIVNMMCSFQD--ENRVYFLLEFVVGGELFtHLRKAGRFPNDVAKFYHAELVLAFEYLHSKDIIYRDLKPENLL 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 LGDDGHVKIADFGVSNQFEGNDAQLsstAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLH 362
Cdd:PTZ00263  151 LDNKGHVKVTDFGFAKKVPDRTFTL---CGTPEYLAPEVIQSKGH---GKAVDWWTMGVLLYEFIAGYPPFFDDTPFRIY 224
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 363 RKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRI-----GVSDIKLHPW 408
Cdd:PTZ00263  225 EKILAGRLKFPN--WFDGRARDLVKGLLQTDHTKRLgtlkgGVADVKNHPY 273
STKc_PASK cd14004
Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs ...
128-409 2.66e-38

Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PASK (or PASKIN) is a nutrient and energy sensor and thus, plays an important role in maintaining cellular energy homeostasis. It coordinates the utilization of glucose in response to metabolic demand. It contains an N-terminal PAS domain which directly interacts and inhibits a C-terminal catalytic kinase domain. The PAS domain serves as a sensory module for different environmental signals such as light, redox state, and various metabolites. Binding of ligands to the PAS domain causes structural changes which leads to kinase activation and the phosphorylation of substrates to trigger the appropriate cellular response. The PASK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270906 [Multi-domain]  Cd Length: 256  Bit Score: 140.60  E-value: 2.66e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEdrHYAMKVLSKKKLLKQYGFPRRPPPRGSqatqggpakqlLPLErvYQEIAILKKLD 207
Cdd:cd14004     2 YTILKEMGEGAYGQVNLAIYKSK--GKEVVIKFIFKERILVDTWVRDRKLGT-----------VPLE--IHILDTLNKRS 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDpaEDNLYLV----------FDLLRKGPVMEvpcdkpfpEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd14004    67 HPNIVKLLDFFED--DEFYYLVmekhgsgmdlFDFIERKPNMD--------EKEAKYIFRQVADAVKHLHDQGIVHRDIK 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 278 PSNLLLGDDGHVKIADFGVSNQFEgnDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDdy 357
Cdd:cd14004   137 DENVILDGNGTIKLIDFGSAAYIK--SGPFDTFVGTIDYAAPEVL--RGNPYGGKEQDIWALGVLLYTLVFKENPFYN-- 210
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 358 IL-TLHRKIKneavvFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14004   211 IEeILEADLR-----IPY--AVSEDLIDLISRMLNRDVGDRPTIEELLTDPWL 256
STKc_MST1_2 cd06612
Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; ...
193-409 5.58e-38

Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST1, MST2, and related proteins including Drosophila Hippo and Dictyostelium discoideum Krs1 (kinase responsive to stress 1). MST1/2 and Hippo are involved in a conserved pathway that governs cell contact inhibition, organ size control, and tumor development. MST1 activates the mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK) through MKK7 and MEKK1 by acting as a MAPK kinase kinase kinase. Activation of JNK by MST1 leads to caspase activation and apoptosis. MST1 has also been implicated in cell proliferation and differentiation. Krs1 may regulate cell growth arrest and apoptosis in response to cellular stress. The MST1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132943 [Multi-domain]  Cd Length: 256  Bit Score: 139.71  E-value: 5.58e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPV---MEVpCDKPFPEEQARLYLRDIILGLEYLHCQ 269
Cdd:cd06612    42 LQEIIKEISILKQCDSPYIVKYYGSYF--KNTDLWIVMEYCGAGSVsdiMKI-TNKTLTEEEIAAILYQTLKGLEYLHSN 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 270 KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGqsFSGKAlDVWATGVTLYCFVYG 349
Cdd:cd06612   119 KKIHRDIKAGNILLNEEGQAKLADFGVSGQLTDTMAKRNTVIGTPFWMAPEVIQEIG--YNNKA-DIWSLGITAIEMAEG 195
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 350 KCPFIDdyiltLH--RKI----KNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06612   196 KPPYSD-----IHpmRAIfmipNKPPPTLSDPEKWSPEFNDFVKKCLVKDPEERPSAIQLLQHPFI 256
STKc_MAST cd05609
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine ...
246-408 6.00e-38

Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. There are four mammalian MAST kinases, named MAST1-MAST4. MAST1 is also called syntrophin-associated STK (SAST) while MAST2 is also called MAST205. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MAST1, MAST2, and MAST3 bind and phosphorylate the tumor suppressor PTEN, and may contribute to the regulation and stabilization of PTEN. MAST2 is involved in the regulation of the Fc-gamma receptor of the innate immune response in macrophages, and may also be involved in the regulation of the Na+/H+ exchanger NHE3. The MAST kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270760 [Multi-domain]  Cd Length: 280  Bit Score: 140.23  E-value: 6.00e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 246 PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS---------NQFEGN---------DAQL 307
Cdd:cd05609    96 PLPVDMARMYFAETVLALEYLHSYGIVHRDLKPDNLLITSMGHIKLTDFGLSkiglmslttNLYEGHiekdtreflDKQV 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 308 sstAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPE-VSEDLKDLI 386
Cdd:cd05609   176 ---CGTPEYIAPEVILRQGY---GKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIEWPEGDDaLPDDAQDLI 249
                         170       180
                  ....*....|....*....|....*
gi 1384865967 387 LRMLDKNPETRIGVS---DIKLHPW 408
Cdd:cd05609   250 TRLLQQNPLERLGTGgaeEVKQHPF 274
STKc_PhKG1 cd14182
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs ...
194-412 1.30e-37

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 1 subunit (PhKG1) is also referred to as the muscle gamma isoform. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271084 [Multi-domain]  Cd Length: 276  Bit Score: 139.28  E-value: 1.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLD-HVNVVKLievlDDPAEDN--LYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQ 269
Cdd:cd14182    54 EATLKEIDILRKVSgHPNIIQL----KDTYETNtfFFLVFDLMKKGELFDYLTEKvTLSEKETRKIMRALLEVICALHKL 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 270 KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAIS---DSGQSFSGKALDVWATGVTLYCF 346
Cdd:cd14182   130 NIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGE-KLREVCGTPGYLAPEIIEcsmDDNHPGYGKEVDMWSTGVIMYTL 208
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 347 VYGKCPFIDDYILTLHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKH 412
Cdd:cd14182   209 LAGSPPFWHRKQMLMLRMIMSGNYQFgsPEWDDRSDTVKDLISRFLVVQPQKRYTAEEALAHPFFQQY 276
STKc_SnRK2 cd14662
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
127-408 1.59e-37

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271132 [Multi-domain]  Cd Length: 257  Bit Score: 138.36  E-value: 1.59e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrppPRGSQATqggpakqllplERVYQEIAILKKL 206
Cdd:cd14662     1 RYELVKDIGSGNFGVARLMRNKETKELVAVKYI----------------ERGLKID-----------ENVQREIINHRSL 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAedNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLgd 285
Cdd:cd14662    54 RHPNIIRFKEVVLTPT--HLAIVMEYAAGGELFERICNAgRFSEDEARYFFQQLISGVSYCHSMQICHRDLKLENTLL-- 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DG----HVKIADFGVSNQFEGNdAQLSSTAGTPAFMAPEAISDsgQSFSGKALDVWATGVTLYCFVYGKCPFID-----D 356
Cdd:cd14662   130 DGspapRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLSR--KEYDGKVADVWSCGVTLYVMLVGAYPFEDpddpkN 206
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 357 YILTLHRkIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14662   207 FRKTIQR-IMSVQYKIPDYVRVSQDCRHLLSRIFVANPAKRITIPEIKNHPW 257
STKc_MLCK-like cd14006
Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs ...
134-408 1.66e-37

Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This family is composed of MLCKs and related MLCK-like kinase domains from giant STKs such as titin, obscurin, SPEG, Unc-89, Trio, kalirin, and Twitchin. Also included in this family are Death-Associated Protein Kinases (DAPKs) and Death-associated protein kinase-Related Apoptosis-inducing protein Kinase (DRAKs). MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. Titin, obscurin, Twitchin, and SPEG are muscle proteins involved in the contractile apparatus. The giant STKs are multidomain proteins containing immunoglobulin (Ig), fibronectin type III (FN3), SH3, RhoGEF, PH and kinase domains. Titin, obscurin, Twitchin, and SPEG contain many Ig domain repeats at the N-terminus, while Trio and Kalirin contain spectrin-like repeats. The MLCK-like family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270908 [Multi-domain]  Cd Length: 247  Bit Score: 138.17  E-value: 1.66e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfPRRPPPRgsqatqggpakqllplERVYQEIAILKKLDHVNVVK 213
Cdd:cd14006     1 LGRGRFGVVKRCIEKATGREFAAKFI-----------PKRDKKK----------------EAVLREISILNQLQHPRIIQ 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDPAEdnLYLVFDLLRKGPVMEVpCDKPF--PEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL--GDDGHV 289
Cdd:cd14006    54 LHEAYESPTE--LVLILELCSGGELLDR-LAERGslSEEEVRTYMRQLLEGLQYLHNHHILHLDLKPENILLadRPSPQI 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 290 KIADFGVSNQFEGnDAQLSSTAGTPAFMAPEAISDSGQSFsgkALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEA 369
Cdd:cd14006   131 KIIDFGLARKLNP-GEELKEIFGTPEFVAPEIVNGEPVSL---ATDMWSIGVLTYVLLSGLSPFLGEDDQETLANISACR 206
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1384865967 370 VVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14006   207 VDFSEEyfSSVSQEAKDFIRKLLVKEPRKRPTAQEALQHPW 247
STKc_NUAK2 cd14161
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs ...
126-409 1.84e-37

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. NUAK2 is implicated in regulating actin stress fiber assembly through its association with myosin phosphatase Rho-interacting protein (MRIP), which leads to an increase in myosin regulatory light chain (MLC) phosphorylation. It is also associated with tumor growth, migration, and oncogenicity of melanoma cells. The NUAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271063 [Multi-domain]  Cd Length: 255  Bit Score: 138.16  E-value: 1.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAyNESEDRHYAMKVLskkkllkqygfpRRPPPRGSQatqggpakQLLPLERvyqEIAILKK 205
Cdd:cd14161     3 HRYEFLETLGKGTYGRVKKA-RDSSGRLVAIKSI------------RKDRIKDEQ--------DLLHIRR---EIEIMSS 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14161    59 LNHPHIISVYEVFEN--SSKIVIVMEYASRGDLYDYISERqRLSELEARHFFRQIVSAVHYCHANGIVHRDLKLENILLD 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQFEGnDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRK 364
Cdd:cd14161   137 ANGNIKIADFGLSNLYNQ-DKFLQTYCGSPLYASPEIV--NGRPYIGPEVDSWSLGVLLYILVHGTMPFDGHDYKILVKQ 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1384865967 365 IKNEAVVFPEEPevsEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14161   214 ISSGAYREPTKP---SDACGLIRWLLMVNPERRATLEDVASHWWV 255
STKc_PKA cd14209
Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze ...
127-408 2.22e-37

Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271111 [Multi-domain]  Cd Length: 290  Bit Score: 139.08  E-value: 2.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQygfprrppprgsqatqggpaKQLlplERVYQEIAILKKL 206
Cdd:cd14209     2 DFDRIKTLGTGSFGRVMLVRHKETGNYYAMKILDKQKVVKL--------------------KQV---EHTLNEKRILQAI 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDpaEDNLYLV---------FDLLRKgpvmevpcDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd14209    59 NFPFLVKLEYSFKD--NSNLYMVmeyvpggemFSHLRR--------IGRFSEPHARFYAAQIVLAFEYLHSLDLIYRDLK 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 278 PSNLLLGDDGHVKIADFGVSNQFEGNDAQLsstAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDY 357
Cdd:cd14209   129 PENLLIDQQGYIKVTDFGFAKRVKGRTWTL---CGTPEYLAPEIILSKGY---NKAVDWWALGVLIYEMAAGYPPFFADQ 202
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 358 ILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRI-----GVSDIKLHPW 408
Cdd:cd14209   203 PIQIYEKIVSGKVRFPS--HFSSDLKDLLRNLLQVDLTKRFgnlknGVNDIKNHKW 256
STKc_NIM1 cd14075
Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the ...
198-409 3.72e-37

Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIM1 is a widely-expressed kinase belonging to the AMP-activated protein kinase (AMPK) subfamily. Although present in most tissues, NIM1 kinase activity is only observed in the brain and testis. NIM1 is capable of autophosphorylating and activating itself, but may be present in other tissues in the inactive form. The physiological function of NIM1 has yet to be elucidated. The NIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270977 [Multi-domain]  Cd Length: 255  Bit Score: 137.47  E-value: 3.72e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd14075    50 REISSMEKLHHPNIIRLYEVVETLSK--LHLVMEYASGGELYtKISTEGKLSESEAKPLFAQIVSAVKHMHENNIIHRDL 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAISDsgQSFSGKALDVWATGVTLYCFVYGKCPFIDD 356
Cdd:cd14075   128 KAENVFYASNNCVKVGDFGFSTHAK-RGETLNTFCGSPPYAAPELFKD--EHYIGIYVDIWALGVLLYFMVTGVMPFRAE 204
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 357 YILTLHRKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14075   205 TVAKLKKCILEGTYTIP--SYVSEPCQELIRGILQPVPSDRYSIDEIKNSEWL 255
STKc_SnRK2-3 cd14665
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
127-408 4.20e-37

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2, group 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271135 [Multi-domain]  Cd Length: 257  Bit Score: 137.42  E-value: 4.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygfprrpppRGSQATqggpakqllplERVYQEIAILKKL 206
Cdd:cd14665     1 RYELVKDIGSGNFGVARLMRDKQTKELVAVKYIE----------------RGEKID-----------ENVQREIINHRSL 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAedNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLgd 285
Cdd:cd14665    54 RHPNIVRFKEVILTPT--HLAIVMEYAAGGELFERICNAgRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLL-- 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DG----HVKIADFGVSNQFEGNdAQLSSTAGTPAFMAPEAISDsgQSFSGKALDVWATGVTLYCFVYGKCPFID-----D 356
Cdd:cd14665   130 DGspapRLKICDFGYSKSSVLH-SQPKSTVGTPAYIAPEVLLK--KEYDGKIADVWSCGVTLYVMLVGAYPFEDpeeprN 206
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 357 YILTLHRkIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14665   207 FRKTIQR-ILSVQYSIPDYVHISPECRHLISRIFVADPATRITIPEIRNHEW 257
STKc_CRIK cd05601
Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze ...
224-407 6.63e-37

Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CRIK (also called citron kinase) is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger, and a pleckstrin homology (PH) domain, in addition to other motifs. The CRIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270752 [Multi-domain]  Cd Length: 328  Bit Score: 138.60  E-value: 6.63e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 224 DNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
Cdd:cd05601    74 ENLYLVMEYHPGGDLLSLlsRYDDIFEESMARFYLAELVLAIHSLHSMGYVHRDIKPENILIDRTGHIKLADFGSAAKLS 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 302 GNDAQLSSTA-GTPAFMAPE---AISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKN--EAVVFPEE 375
Cdd:cd05601   154 SDKTVTSKMPvGTPDYIAPEvltSMNGGSKGTYGVECDWWSLGIVAYEMLYGKTPFTEDTVIKTYSNIMNfkKFLKFPED 233
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1384865967 376 PEVSEDLKDLILRMLdKNPETRIGVSDIKLHP 407
Cdd:cd05601   234 PKVSESAVDLIKGLL-TDAKERLGYEGLCCHP 264
STKc_PLK1 cd14187
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the ...
194-403 1.14e-36

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. Its localization changes during mitotic progression; associating first with centrosomes in prophase, with kinetochores in prometaphase and metaphase, at the central spindle in anaphase, and in the midbody during telophase. It carries multiple functions throughout the cell cycle through interactions with differrent substrates at these specific subcellular locations. PLK1 is overexpressed in many human cancers and is associated with poor prognosis. The PLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271089 [Multi-domain]  Cd Length: 265  Bit Score: 136.60  E-value: 1.14e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEV-PCDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd14187    52 EKMSMEIAIHRSLAHQHVVGFHGFFED--NDFVYVVLELCRRRSLLELhKRRKALTEPEARYYLRQIILGCQYLHRNRVI 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCP 352
Cdd:cd14187   130 HRDLKLGNLFLNDDMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFE---VDIWSIGCIMYTLLVGKPP 206
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 353 FIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd14187   207 FETSCLKETYLRIKKNEYSIPK--HINPVAASLIQKMLQTDPTARPTINEL 255
STKc_CaMKI_alpha cd14167
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
199-409 1.23e-36

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271069 [Multi-domain]  Cd Length: 263  Bit Score: 136.31  E-value: 1.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVPCDKPF-PEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd14167    51 EIAVLHKIKHPNIVALDDIYE--SGGHLYLIMQLVSGGELFDRIVEKGFyTERDASKLIFQILDAVKYLHDMGIVHRDLK 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 278 PSNLL---LGDDGHVKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPFI 354
Cdd:cd14167   129 PENLLyysLDEDSKIMISDFGLS-KIEGSGSVMSTACGTPGYVAPEVLAQKPYS---KAVDCWSIGVIAYILLCGYPPFY 204
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 355 DDYILTLHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14167   205 DENDAKLFEQILKAEYEFdsPYWDDISDSAKDFIQHLMEKDPEKRFTCEQALQHPWI 261
STKc_RCK1-like cd14096
Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
126-409 1.43e-36

Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal STKs including Saccharomyces cerevisiae RCK1 and RCK2, Schizosaccharomyces pombe Sty1-regulated kinase 1 (Srk1), and similar proteins. RCK1, RCK2 (or Rck2p), and Srk1 are MAPK-activated protein kinases. RCK1 and RCK2 are involved in oxidative and metal stress resistance in budding yeast. RCK2 also regulates rapamycin sensitivity in both S. cerevisiae and Candida albicans. Srk1 is activated by Sty1/Spc1 and is involved in negatively regulating cell cycle progression by inhibiting Cdc25. The RCK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270998 [Multi-domain]  Cd Length: 295  Bit Score: 136.80  E-value: 1.43e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYG-VVRLAYNESEDRHYAMKVLSkkkllkQYGFprrppprGSQATQGGPAKQLLplervyQEIAILK 204
Cdd:cd14096     1 ENYRLINKIGEGAFSnVYKAVPLRNTGKPVAIKVVR------KADL-------SSDNLKGSSRANIL------KEVQIMK 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGP----VMEVPCdkpFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSN 280
Cdd:cd14096    62 RLSHPNIVKLLDFQESD--EYYYIVLELADGGEifhqIVRLTY---FSEDLSRHVITQVASAVKYLHEIGVVHRDIKPEN 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 281 LL---------------LGDD------------------GHVKIADFGVSNQFEgnDAQLSSTAGTPAFMAPEAISDSGQ 327
Cdd:cd14096   137 LLfepipfipsivklrkADDDetkvdegefipgvggggiGIVKLADFGLSKQVW--DSNTKTPCGTVGYTAPEVVKDERY 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 328 SfsgKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKL 405
Cdd:cd14096   215 S---KKVDMWALGCVLYTLLCGFPPFYDESIETLTEKISRGDYTFlsPWWDEISKSAKDLISHLLTVDPAKRYDIDEFLA 291

                  ....
gi 1384865967 406 HPWV 409
Cdd:cd14096   292 HPWI 295
STKc_PhKG2 cd14181
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs ...
127-408 1.52e-36

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 2 subunit (PhKG2) is also referred to as the testis/liver gamma isoform. Mutations in its gene cause autosomal-recessive glycogenosis of the liver. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271083 [Multi-domain]  Cd Length: 279  Bit Score: 136.64  E-value: 1.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKkllkqygfPRRPPPRGSQATQGGPAKqllplervyqEIAILKKL 206
Cdd:cd14181    11 KYDPKEVIGRGVSSVVRRCVHRHTGQEFAVKIIEVT--------AERLSPEQLEEVRSSTLK----------EIHILRQV 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 -DHVNVVKLIEVLDDPAedNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14181    73 sGHPSIITLIDSYESST--FIFLVFDLMRRGELFDYLTEKvTLSEKETRSIMRSLLEAVSYLHANNIVHRDLKPENILLD 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAIS---DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTL 361
Cdd:cd14181   151 DQLHIKLSDFGFSCHLEPGE-KLRELCGTPGYLAPEILKcsmDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQMLM 229
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1384865967 362 HRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14181   230 LRMIMEGRYQFssPEWDDRSSTVKDLISRLLVVDPEIRLTAEQALQHPF 278
STKc_Rim15_like cd05611
Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the ...
133-408 1.85e-36

Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include Saccharomyces cerevisiae Rim15, Schizosaccharomyces pombe cek1, and similar fungal proteins. They contain a central catalytic domain, which contains an insert relative to MAST kinases. In addition, Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. Rim15 (or Rim15p) functions as a regulator of meiosis. It acts as a downstream effector of PKA and regulates entry into stationary phase (G0). Thus, it plays a crucial role in regulating yeast proliferation, differentiation, and aging. Cek1 may facilitate progression of mitotic anaphase. The Rim15-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270762 [Multi-domain]  Cd Length: 263  Bit Score: 135.69  E-value: 1.85e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 133 EIGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPPPRGSQATQggpakqllplerVYQEIAILK-KLDHVNV 211
Cdd:cd05611     3 PISKGAFGSVYLAKKRSTGDYFAIKV-----------LKKSDMIAKNQVTN------------VKAERAIMMiQGESPYV 59
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 212 VKLIEVLDdpAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVK 290
Cdd:cd05611    60 AKLYYSFQ--SKDYLYLVMEYLNGGDCASlIKTLGGLPEDWAKQYIAEVVLGVEDLHQRGIIHRDIKPENLLIDQTGHLK 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 291 IADFGVSNQFEGNdAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAV 370
Cdd:cd05611   138 LTDFGLSRNGLEK-RHNKKFVGTPDYLAPETILGVGDD---KMSDWWSLGCVIFEFLFGYPPFHAETPDAVFDNILSRRI 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1384865967 371 VFPEEPE--VSEDLKDLILRMLDKNPETRIG---VSDIKLHPW 408
Cdd:cd05611   214 NWPEEVKefCSPEAVDLINRLLCMDPAKRLGangYQEIKSHPF 256
STKc_Kin4 cd14076
Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the ...
128-409 1.91e-36

Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kin4 is a central component of the spindle position checkpoint (SPOC), which monitors spindle position and regulates the mitotic exit network (MEN). Kin4 associates with spindle pole bodies in mother cells to inhibit MEN signaling and delay mitosis until the anaphase nucleus is properly positioned along the mother-bud axis. Kin4 activity is regulated by both the bud neck-associated kinase Elm1 and protein phosphatase 2A. The Kin4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270978 [Multi-domain]  Cd Length: 270  Bit Score: 136.07  E-value: 1.91e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHyamkvlskkkllkqygfprRPPPRGS-----QATQGGPAKQLlpleRVYQEIAI 202
Cdd:cd14076     3 YILGRTLGEGEFGKVKLGWPLPKANH-------------------RSGVQVAiklirRDTQQENCQTS----KIMREINI 59
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 203 LKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQA--RLYLRdIILGLEYLHCQKIVHRDIKPSN 280
Cdd:cd14076    60 LKGLTHPNIVRLLDVLK--TKKYIGIVLEFVSGGELFDYILARRRLKDSVacRLFAQ-LISGVAYLHKKGVVHRDLKLEN 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 281 LLLGDDGHVKIADFGVSNQFEGNDAQLSSTA-GTPAFMAPEAISdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDY-- 357
Cdd:cd14076   137 LLLDKNRNLVITDFGFANTFDHFNGDLMSTScGSPCYAAPELVV-SDSMYAGRKADIWSCGVILYAMLAGYLPFDDDPhn 215
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 358 -----ILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14076   216 pngdnVPRLYRYICNTPLIFPE--YVTPKARDLLRRILVPNPRKRIRLSAIMRHAWL 270
STKc_CaMKI_beta cd14169
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
128-410 4.01e-36

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271071 [Multi-domain]  Cd Length: 277  Bit Score: 135.40  E-value: 4.01e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPPpRGSQATqggpakqllplerVYQEIAILKKLD 207
Cdd:cd14169     5 YELKEKLGEGAFSEVVLAQERGSQRLVALKC-----------IPKKAL-RGKEAM-------------VENEIAVLRRIN 59
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPAedNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG-- 284
Cdd:cd14169    60 HENIVSLEDIYESPT--HLYLAMELVTGGELFDRIIERgSYTEKDASQLIGQVLQAVKYLHQLGIVHRDLKPENLLYAtp 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 -DDGHVKIADFGVSNQFEGNdaQLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHR 363
Cdd:cd14169   138 fEDSKIMISDFGLSKIEAQG--MLSTACGTPGYVAPELLE---QKPYGKAVDVWAIGVISYILLCGYPPFYDENDSELFN 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1384865967 364 KIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd14169   213 QILKAEYEFdsPYWDDISESAKDFIRHLLERDPEKRFTCEQALQHPWIS 261
STKc_RSK_C cd14091
C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs ...
127-410 4.01e-36

C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), 90 kDa ribosomal protein S6 kinases (p90-RSKs), or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270993 [Multi-domain]  Cd Length: 291  Bit Score: 135.45  E-value: 4.01e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLLPLER-VYQEIAILKK 205
Cdd:cd14091     1 EYEIKEEIGKGSYSVCKRCIHKATGKEYAV-------------------------------KIIDKSKRdPSEEIEILLR 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 L-DHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd14091    50 YgQHPNIITLRDVYDD--GNSVYLVTELLRGGELLDRILRQKfFSEREASAVMKTLTKTVEYLHSQGVVHRDLKPSNILY 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 GDDGH----VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPFID---- 355
Cdd:cd14091   128 ADESGdpesLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKKQGYD---AACDIWSLGVLLYTMLAGYTPFASgpnd 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 356 --DYILTlhrKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd14091   205 tpEVILA---RIGSGKIDLsgGNWDHVSDSAKDLVRKMLHVDPSQRPTAAQVLQHPWIR 260
STKc_SLK_like cd06611
Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the ...
128-414 7.63e-36

Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the subfamily include SLK, STK10 (also called LOK for Lymphocyte-Oriented Kinase), SmSLK (Schistosoma mansoni SLK), and related proteins. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It also plays a role in mediating actin reorganization. STK10 is responsible in regulating the CD28 responsive element in T cells, as well as leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. SmSLK is capable of activating the MAPK Jun N-terminal kinase (JNK) pathway in human embryonic kidney cells as well as in Xenopus oocytes. It may participate in regulating MAPK cascades during host-parasite interactions. The SLK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132942 [Multi-domain]  Cd Length: 280  Bit Score: 134.49  E-value: 7.63e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAmkvlskkkllkqygfprrppprgSQATQGGPAKQLlplERVYQEIAILKKLD 207
Cdd:cd06611     7 WEIIGELGDGAFGKVYKAQHKETGLFAA-----------------------AKIIQIESEEEL---EDFMVEIDILSECK 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDpaEDNLYLVFDLLRKGPV--MEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGD 285
Cdd:cd06611    61 HPNIVGLYEAYFY--ENKLWILIEFCDGGALdsIMLELERGLTEPQIRYVCRQMLEALNFLHSHKVIHRDLKAGNILLTL 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI---SDSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLH 362
Cdd:cd06611   139 DGDVKLADFGVSAKNKSTLQKRDTFIGTPYWMAPEVVaceTFKDNPYDYKA-DIWSLGITLIELAQMEPPHHELNPMRVL 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 363 RKI-KNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGE 414
Cdd:cd06611   218 LKIlKSEPPTLDQPSKWSSSFNDFLKSCLVKDPDDRPTAAELLKHPFVSDQSD 270
STKc_PKB cd05571
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer ...
244-408 7.95e-36

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. There are three PKB isoforms from different genes, PKB-alpha (or Akt1), PKB-beta (or Akt2), and PKB-gamma (or Akt3). PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. It is activated downstream of phosphoinositide 3-kinase (PI3K) and plays important roles in diverse cellular functions including cell survival, growth, proliferation, angiogenesis, motility, and migration. PKB also has a central role in a variety of human cancers, having been implicated in tumor initiation, progression, and metastasis. The PKB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and PI3K.


Pssm-ID: 270723 [Multi-domain]  Cd Length: 322  Bit Score: 135.56  E-value: 7.95e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 244 DKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQfEGNDAQLSST-AGTPAFMAPEAI 322
Cdd:cd05571    89 ERVFSEDRTRFYGAEIVLALGYLHSQGIVYRDLKLENLLLDKDGHIKITDFGLCKE-EISYGATTKTfCGTPEYLAPEVL 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 323 SDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIG--- 399
Cdd:cd05571   168 EDNDY---GRAVDWWGLGVVMYEMMCGRLPFYNRDHEVLFELILMEEVRFP--STLSPEAKSLLAGLLKKDPKKRLGggp 242
                         170
                  ....*....|.
gi 1384865967 400 --VSDIKLHPW 408
Cdd:cd05571   243 rdAKEIMEHPF 253
PKc_Mps1 cd14131
Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle ...
185-407 1.07e-35

Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK); Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TTK/Mps1 is a spindle checkpoint kinase that was first discovered due to its necessity in centrosome duplication in budding yeast. It was later found to function in the spindle assembly checkpoint, which monitors the proper attachment of chromosomes to the mitotic spindle. In yeast, substrates of Mps1 include the spindle pole body components Spc98p, Spc110p, and Spc42p. The TTK/Mps1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271033 [Multi-domain]  Cd Length: 271  Bit Score: 133.88  E-value: 1.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 185 GPAKQLLPLERV-------------YQEIAILKKL-DHVNVVKLI--EVLDDPaeDNLYLVF-----DL---LRKGPvme 240
Cdd:cd14131    22 NPKKKIYALKRVdlegadeqtlqsyKNEIELLKKLkGSDRIIQLYdyEVTDED--DYLYMVMecgeiDLatiLKKKR--- 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 241 vpcDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLgDDGHVKIADFGVSNQFEGNDAQLS--STAGTPAFMA 318
Cdd:cd14131    97 ---PKPIDPNFIRYYWKQMLEAVHTIHEEGIVHSDLKPANFLL-VKGRLKLIDFGIAKAIQNDTTSIVrdSQVGTLNYMS 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 319 PEAISDSGQSFSGKAL-------DVWATGVTLYCFVYGKCPF--IDDYILTLHRkIKNEAVVFPEEPEVSEDLKDLILRM 389
Cdd:cd14131   173 PEAIKDTSASGEGKPKskigrpsDVWSLGCILYQMVYGKTPFqhITNPIAKLQA-IIDPNHEIEFPDIPNPDLIDVMKRC 251
                         250
                  ....*....|....*...
gi 1384865967 390 LDKNPETRIGVSDIKLHP 407
Cdd:cd14131   252 LQRDPKKRPSIPELLNHP 269
STKc_ROCK cd05596
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
134-407 1.26e-35

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK is also referred to as Rho-associated kinase or simply as Rho kinase. It contains an N-terminal extension, a catalytic kinase domain, and a long C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain. It is activated via interaction with Rho GTPases and is involved in many cellular functions including contraction, adhesion, migration, motility, proliferation, and apoptosis. The ROCK subfamily consists of two isoforms, ROCK1 and ROCK2, which may be functionally redundant in some systems, but exhibit different tissue distributions. Both isoforms are ubiquitously expressed in most tissues, but ROCK2 is more prominent in brain and skeletal muscle while ROCK1 is more pronounced in the liver, testes, and kidney. Studies in knockout mice result in different phenotypes, suggesting that the two isoforms do not compensate for each other during embryonic development. The ROCK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270747 [Multi-domain]  Cd Length: 352  Bit Score: 135.97  E-value: 1.26e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLLPLERV--------YQEIAILKk 205
Cdd:cd05596    34 IGRGAFGEVQLVRHKSTKKVYAM-------------------------------KLLSKFEMIkrsdsaffWEERDIMA- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 ldHVN---VVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:cd05596    82 --HANsewIVQLHYAFQD--DKYLYMVMDYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFVHRDVKPDNML 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 LGDDGHVKIADFGVSNQFEGNDAQLSSTA-GTPAFMAPEAI-SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILT 360
Cdd:cd05596   158 LDASGHLKLADFGTCMKMDKDGLVRSDTAvGTPDYISPEVLkSQGGDGVYGRECDWWSVGVFLYEMLVGDTPFYADSLVG 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 361 LHRKIKN--EAVVFPEEPEVSEDLKDLILRMLdKNPETRIG---VSDIKLHP 407
Cdd:cd05596   238 TYGKIMNhkNSLQFPDDVEISKDAKSLICAFL-TDREVRLGrngIEEIKAHP 288
STKc_LATS cd05598
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the ...
126-408 1.60e-35

Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS was originally identified in Drosophila using a screen for genes whose inactivation led to overproliferation of cells. In tetrapods, there are two LATS isoforms, LATS1 and LATS2. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. LATS functions as a tumor suppressor and is implicated in cell cycle regulation. The LATS subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270749 [Multi-domain]  Cd Length: 333  Bit Score: 135.14  E-value: 1.60e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLkqygfprrpppRGSQATQggpakqllplerVYQEIAILKK 205
Cdd:cd05598     1 SMFEKIKTIGVGAFGEVSLVRKKDTNALYAMKTLRKKDVL-----------KRNQVAH------------VKAERDILAE 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd05598    58 ADNEWVVKLYYSFQD--KENLYFVMDYIPGGDLMSLLIKKGiFEEDLARFYIAELVCAIESVHKMGFIHRDIKPDNILID 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQFE-GNDA---QLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILT 360
Cdd:cd05598   136 RDGHIKLTDFGLCTGFRwTHDSkyyLAHSLVGTPNYIAPEVLLRTGY---TQLCDWWSVGVILYEMLVGQPPFLAQTPAE 212
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 361 LHRKIKN--EAVVFPEEPEVSEDLKDLILRMLdKNPETRIG---VSDIKLHPW 408
Cdd:cd05598   213 TQLKVINwrTTLKIPHEANLSPEAKDLILRLC-CDAEDRLGrngADEIKAHPF 264
STKc_DAPK1 cd14194
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs ...
126-409 1.68e-35

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. It is Ca2+/calmodulin (CaM)-regulated and actin-associated protein that contains an N-terminal kinase domain followed by an autoinhibitory CaM binding region and a large C-terminal extension with multiple functional domains including ankyrin (ANK) repeats, a cytoskeletal binding domain, a Death domain, and a serine-rich tail. Loss of DAPK1 expression, usually because of DNA methylation, is implicated in many tumor types. DAPK1 is highly abundant in the brain and has also been associated with neurodegeneration. The DAPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271096 [Multi-domain]  Cd Length: 269  Bit Score: 133.22  E-value: 1.68e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKvlskkkllkqygFPRRpppRGSQATQGGPAKqllplERVYQEIAILKK 205
Cdd:cd14194     5 DYYDTGEELGSGQFAVVKKCREKSTGLQYAAK------------FIKK---RRTKSSRRGVSR-----EDIEREVSILKE 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14194    65 IQHPNVITLHEVYENKTD--VILILELVAGGELFDFLAEKeSLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDG----HVKIADFGVSNQFE-GNDaqLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDyil 359
Cdd:cd14194   143 DRNvpkpRIKIIDFGLAHKIDfGNE--FKNIFGTPEFVAPEIVNYEPL---GLEADMWSIGVITYILLSGASPFLGD--- 214
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 360 TLHRKIKNEAVV---FPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14194   215 TKQETLANVSAVnyeFEDEyfSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWI 269
STKc_PLK4 cd14186
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the ...
193-409 1.73e-35

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK4, also called SAK or STK18, is structurally different from other PLKs in that it contains only one polo box that can form two adjacent polo boxes and a functional PDB by homodimerization. It is required for late mitotic progression, cell survival, and embryonic development. It localizes to centrosomes and is required for centriole duplication and chromosomal stability. Overexpression of PLK4 may be associated with colon tumors. The PLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271088 [Multi-domain]  Cd Length: 256  Bit Score: 133.06  E-value: 1.73e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCD--KPFPEEQARLYLRDIILGLEYLHCQK 270
Cdd:cd14186    45 VQRVRNEVEIHCQLKHPSILELYNYFED--SNYVYLVLEMCHNGEMSRYLKNrkKPFTEDEARHFMHQIVTGMLYLHSHG 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGK 350
Cdd:cd14186   123 ILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHFTMCGTPNYISPEIATRSAH---GLESDVWSLGCMFYTLLVGR 199
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 351 CPFIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14186   200 PPFDTDTVKNTLNKVVLADYEMPA--FLSREAQDLIHQLLRKNPADRLSLSSVLDHPFM 256
STKc_MSK_N cd05583
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
223-408 1.81e-35

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270735 [Multi-domain]  Cd Length: 268  Bit Score: 133.29  E-value: 1.81e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF- 300
Cdd:cd05583    71 DAKLHLILDYVNGGELFTHLYQReHFTESEVRIYIGEIVLALEHLHKLGIIYRDIKLENILLDSEGHVVLTDFGLSKEFl 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 301 EGNDAQLSSTAGTPAFMAPEAISdSGQSFSGKALDVWATGVTLYCFVYGKCPF-IDDYILT---LHRKIKNEAVVFPeeP 376
Cdd:cd05583   151 PGENDRAYSFCGTIEYMAPEVVR-GGSDGHDKAVDWWSLGVLTYELLTGASPFtVDGERNSqseISKRILKSHPPIP--K 227
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1384865967 377 EVSEDLKDLILRMLDKNPETRIG-----VSDIKLHPW 408
Cdd:cd05583   228 TFSAEAKDFILKLLEKDPKKRLGagprgAHEIKEHPF 264
STKc_CaMKI_gamma cd14166
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
134-419 2.05e-35

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271068 [Multi-domain]  Cd Length: 285  Bit Score: 133.58  E-value: 2.05e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsQATQGGPAKQLLPLErvyQEIAILKKLDHVNVVK 213
Cdd:cd14166    11 LGSGAFSEVYLVKQRSTGKLYAL-----------------------KCIKKSPLSRDSSLE---NEIAVLKRIKHENIVT 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDdpAEDNLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL---GDDGHV 289
Cdd:cd14166    65 LEDIYE--STTHYYLVMQLVSGGELFDRILERGvYTEKDASRVINQVLSAVKYLHENGIVHRDLKPENLLYltpDENSKI 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 290 KIADFGVSNQFEgnDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEA 369
Cdd:cd14166   143 MITDFGLSKMEQ--NGIMSTACGTPGYVAPEVLAQKPYS---KAVDCWSIGVITYILLCGYPPFYEETESRLFEKIKEGY 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 370 VVFpEEP---EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV---TKHGEEPLPS 419
Cdd:cd14166   218 YEF-ESPfwdDISESAKDFIRHLLEKNPSKRYTCEKALSHPWIignTALHRDIYPS 272
STKc_PSKH1 cd14087
Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the ...
199-409 2.49e-35

Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PSKH1 is an autophosphorylating STK that is expressed ubiquitously and exhibits multiple intracellular localizations including the centrosome, Golgi apparatus, and splice factor compartments. It contains a catalytic kinase domain and an N-terminal SH4-like motif that is acylated to facilitate membrane attachment. PSKH1 plays a rile in the maintenance of the Golgi apparatus, an important organelle within the secretory pathway. It may also function as a novel splice factor and a regulator of prostate cancer cell growth. The PSKH1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270989 [Multi-domain]  Cd Length: 259  Bit Score: 132.66  E-value: 2.49e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd14087    47 ELNVLRRVRHTNIIQLIEVFE--TKERVYMVMELATGGELFDrIIAKGSFTERDATRVLQMVLDGVKYLHGLGITHRDLK 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 278 PSNLLLGDDGH---VKIADFGVSNQFEGNDAQL-SSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPF 353
Cdd:cd14087   125 PENLLYYHPGPdskIMITDFGLASTRKKGPNCLmKTTCGTPEYIAPEILLRKPYT---QSVDMWAVGVIAYILLSGTMPF 201
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 354 IDDYILTLHRKIKNEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14087   202 DDDNRTRLYRQILRAKYSYSGEPwpSVSNLAKDFIDRLLTVNPGERLSATQALKHPWI 259
STKc_Mnk cd14090
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase ...
128-409 2.92e-35

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase signal-integrating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270992 [Multi-domain]  Cd Length: 289  Bit Score: 133.31  E-value: 2.92e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEI-GKGAYGVVRLAYNESEDRHYAMKVLSKKkllkqygfprrppPRGSQAtqggpakqllpleRVYQEIAILKKL 206
Cdd:cd14090     3 YKLTGELlGEGAYASVQTCINLYTGKEYAVKIIEKH-------------PGHSRS-------------RVFREVETLHQC 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 D-HVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14090    57 QgHPNILQLIEYFED--DERFYLVFEKMRGGPLLShIEKRVHFTEQEASLVVRDIASALDFLHDKGIAHRDLKPENILCE 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGH---VKIADFGVSN--QFEGNDA------QLSSTAGTPAFMAPEAISD-SGQSFS-GKALDVWATGVTLYCFVYGKC 351
Cdd:cd14090   135 SMDKvspVKICDFDLGSgiKLSSTSMtpvttpELLTPVGSAEYMAPEVVDAfVGEALSyDKRCDLWSLGVILYIMLCGYP 214
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 352 PFI----------------DDYILTLHRkIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14090   215 PFYgrcgedcgwdrgeacqDCQELLFHS-IQEGEYEFPEKewSHISAEAKDLISHLLVRDASQRYTAEQVLQHPWV 289
STKc_Nek6_7 cd08224
Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related ...
128-403 3.32e-35

Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 and Nek7 are the shortest Neks, consisting only of the catalytic domain and a very short N-terminal extension. They show distinct expression patterns and both appear to be downstream substrates of Nek9. They are required for mitotic spindle formation and cytokinesis. They may also be regulators of the p70 ribosomal S6 kinase. Nek6/7 is part of a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270863 [Multi-domain]  Cd Length: 262  Bit Score: 132.39  E-value: 3.32e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrpppRGSQATQGGPAKQLlplERVYQEIAILKKLD 207
Cdd:cd08224     2 YEIEKKIGKGQFSVVYRARCLLDGRLVAL--------------------KKVQIFEMMDAKAR---QDCLKEIDLLQQLN 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLievLDDPAEDN-LYLVFDLLRKGPVME-----VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNL 281
Cdd:cd08224    59 HPNIIKY---LASFIENNeLNIVLELADAGDLSRlikhfKKQKRLIPERTIWKYFVQLCSALEHMHSKRIMHRDIKPANV 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 282 LLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGkalDVWATGVTLYCFVYGKCPFIDDYI--L 359
Cdd:cd08224   136 FITANGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIREQGYDFKS---DIWSLGCLLYEMAALQSPFYGEKMnlY 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1384865967 360 TLHRKIKNEAvvFPEEPE--VSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd08224   213 SLCKKIEKCE--YPPLPAdlYSQELRDLVAACIQPDPEKRPDISYV 256
STKc_Aurora-A cd14116
Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer ...
125-410 3.72e-35

Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2, which also localizes the kinase to spindle microtubules. Aurora-A is overexpressed in many cancer types such as prostate, ovarian, breast, bladder, gastric, and pancreatic. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271018 [Multi-domain]  Cd Length: 258  Bit Score: 132.00  E-value: 3.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrppprgSQATQGGPAKQLlplervYQEIAILK 204
Cdd:cd14116     4 LEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFK-----------------AQLEKAGVEHQL------RREVEIQS 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd14116    61 HLRHPNILRLYGYFHDATR--VYLILEYAPLGTVYrELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLL 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 GDDGHVKIADFGVSnqFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKaLDVWATGVTLYCFVYGKCPFIDDYILTLHR 363
Cdd:cd14116   139 GSAGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMI--EGRMHDEK-VDLWSLGVLCYEFLVGKPPFEANTYQETYK 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1384865967 364 KIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd14116   214 RISRVEFTFP--DFVTEGARDLISRLLKHNPSQRPMLREVLEHPWIT 258
STKc_p70S6K cd05584
Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs ...
202-408 5.18e-35

Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p70S6K (or S6K) contains only one catalytic kinase domain, unlike p90 ribosomal S6 kinases (RSKs). It acts as a downstream effector of the STK mTOR (mammalian Target of Rapamycin) and plays a role in the regulation of the translation machinery during protein synthesis. p70S6K also plays a pivotal role in regulating cell size and glucose homeostasis. Its targets include S6, the translation initiation factor eIF3, and the insulin receptor substrate IRS-1, among others. Mammals contain two isoforms of p70S6K, named S6K1 and S6K2 (or S6K-beta). The p70S6K subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270736 [Multi-domain]  Cd Length: 323  Bit Score: 133.30  E-value: 5.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 202 ILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPV-MEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSN 280
Cdd:cd05584    53 ILEAVKHPFIVDLHYAFQTGGK--LYLILEYLSGGELfMHLEREGIFMEDTACFYLAEITLALGHLHSLGIIYRDLKPEN 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 281 LLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILT 360
Cdd:cd05584   131 ILLDAQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILTRSGH---GKAVDWWSLGALMYDMLTGAPPFTAENRKK 207
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 361 LHRKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIG--VSD---IKLHPW 408
Cdd:cd05584   208 TIDKILKGKLNLP--PYLTNEARDLLKKLLKRNVSSRLGsgPGDaeeIKAHPF 258
PTKc cd00192
Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
198-403 7.03e-35

Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers.The PTK family is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270623 [Multi-domain]  Cd Length: 262  Bit Score: 131.51  E-value: 7.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDL---------LRK-GPVMEVPCDKPFPEEQARLYLRDIILGLEYLH 267
Cdd:cd00192    45 KEARVMKKLGHPNVVRLLGVCTE--EEPLYLVMEYmeggdlldfLRKsRPVFPSPEPSTLSLKDLLSFAIQIAKGMEYLA 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 268 CQKIVHRDIKPSNLLLGDDGHVKIADFGVS-NQFEGNDAQLSSTAGTPAF-MAPEAISDsgQSFSGKAlDVWATGVTLY- 344
Cdd:cd00192   123 SKKFVHRDLAARNCLVGEDLVVKISDFGLSrDIYDDDYYRKKTGGKLPIRwMAPESLKD--GIFTSKS-DVWSFGVLLWe 199
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 345 CFVYGKCPFIDDYILTLHRKIKNEavVFPEEPE-VSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd00192   200 IFTLGATPYPGLSNEEVLEYLRKG--YRLPKPEnCPDELYELMLSCWQLDPEDRPTFSEL 257
STKc_nPKC_theta_like cd05592
Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and ...
223-407 7.43e-35

Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. There are four nPKC isoforms, delta, epsilon, eta, and theta. The nPKC-theta-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270744 [Multi-domain]  Cd Length: 320  Bit Score: 132.89  E-value: 7.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
Cdd:cd05592    68 ESHLFFVMEYLNGGDLMfHIQQSGRFDEDRARFYGAEIICGLQFLHSRGIIYRDLKLDNVLLDREGHIKIADFGMCKENI 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 302 GNDAQLSSTAGTPAFMAPEAIsdSGQSFSgKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSED 381
Cdd:cd05592   148 YGENKASTFCGTPDYIAPEIL--KGQKYN-QSVDWWSFGVLLYEMLIGQSPFHGEDEDELFWSICNDTPHYPR--WLTKE 222
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1384865967 382 LKDLILRMLDKNPETRIGV-----SDIKLHP 407
Cdd:cd05592   223 AASCLSLLLERNPEKRLGVpecpaGDIRDHP 253
STKc_DCKL2 cd14184
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called ...
126-408 8.32e-35

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL2 (or DCAMKL2) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL2 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL2 has been shown to interact with tubulin, JIP1/2, JNK, neurabin 2, and actin. It is associated with the terminal segments of axons and dendrites, and may function as a phosphorylation-dependent switch to control microtubule dynamics in neuronal growth cones. The DCKL2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271086 [Multi-domain]  Cd Length: 259  Bit Score: 131.31  E-value: 8.32e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygfprRPPPRGSQatqggpakqllplERVYQEIAILKK 205
Cdd:cd14184     1 EKYKIGKVIGDGNFAVVKECVERSTGKEFALKIID------------KAKCCGKE-------------HLIENEVSILRR 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14184    56 VKHPNIIMLIEEMDTPAE--LYLVMELVKGGDLFDaITSSTKYTERDASAMVYNLASALKYLHGLCIVHRDIKPENLLVC 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 D--DG--HVKIADFGVSNQFEGndaQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILT 360
Cdd:cd14184   134 EypDGtkSLKLGDFGLATVVEG---PLYTVCGTPTYVAPEIIAETGY---GLKVDIWAAGVITYILLCGFPPFRSENNLQ 207
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 361 --LHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14184   208 edLFDQILLGKLEFPSPywDNITDSAKELISHMLQVNVEARYTAEQILSHPW 259
STKc_CaMKIV cd14085
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
128-410 8.32e-35

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKIV is found predominantly in neurons and immune cells. It is activated by the binding of calcium/CaM and phosphorylation by CaMKK (alpha or beta). The CaMKK-CaMKIV cascade participates in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors. It also is implicated in T-cell development and signaling, cytokine secretion, and signaling through Toll-like receptors, and is thus, pivotal in immune response and inflammation. The CaMKIV subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270987 [Multi-domain]  Cd Length: 294  Bit Score: 132.26  E-value: 8.32e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrppprgsqatqggpaKQLLPLERVYQEIAILKKLD 207
Cdd:cd14085     5 FEIESELGRGATSVVYRCRQKGTQKPYAVKKL----------------------------KKTVDKKIVRTEIGVLLRLS 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDKPF-PEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL---L 283
Cdd:cd14085    57 HPNIIKLKEIFETPTE--ISLVLELVTGGELFDRIVEKGYySERDAADAVKQILEAVAYLHENGIVHRDLKPENLLyatP 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 GDDGHVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAIsdSGQSFsGKALDVWATGVTLYCFVYGKCPFIDD----YIl 359
Cdd:cd14085   135 APDAPLKIADFGLSKIVD-QQVTMKTVCGTPGYCAPEIL--RGCAY-GPEVDMWSVGVITYILLCGFEPFYDErgdqYM- 209
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 360 tlHRKIKN--EAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd14085   210 --FKRILNcdYDFVSPWWDDVSLNAKDLVKKLIVLDPKKRLTTQQALQHPWVT 260
STKc_ASK cd06624
Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs ...
134-409 8.88e-35

Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs) and include ASK1, ASK2, and MAPKKK15. ASK1 (also called MAPKKK5) functions in the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. It plays important roles in cytokine and stress responses, as well as in reactive oxygen species-mediated cellular responses. ASK1 is implicated in various diseases mediated by oxidative stress including inschemic heart disease, hypertension, vessel injury, brain ischemia, Fanconi anemia, asthma, and pulmonary edema, among others. ASK2 (also called MAPKKK6) functions only in a heteromeric complex with ASK1, and can activate ASK1 by direct phosphorylation. The function of MAPKKK15 is still unknown. The ASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270794 [Multi-domain]  Cd Length: 268  Bit Score: 131.38  E-value: 8.88e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfpRRPPPRGSQATQggpakqllPLErvyQEIAILKKLDHVNVVK 213
Cdd:cd06624    16 LGKGTFGVVYAARDLSTQVRIAI---------------KEIPERDSREVQ--------PLH---EEIALHSRLSHKNIVQ 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLddpAEDNLYLVF----------DLLRK--GPVMEvpcdkpfPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNL 281
Cdd:cd06624    70 YLGSV---SEDGFFKIFmeqvpggslsALLRSkwGPLKD-------NENTIGYYTKQILEGLKYLHDNKIVHRDIKGDNV 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 282 LLGD-DGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDdyilt 360
Cdd:cd06624   140 LVNTySGVVKISDFGTSKRLAGINPCTETFTGTLQYMAPEVI-DKGQRGYGPPADIWSLGCTIIEMATGKPPFIE----- 213
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 361 lhrKIKNEAVVF--------PEEPEV-SEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06624   214 ---LGEPQAAMFkvgmfkihPEIPESlSEEAKSFILRCFEPDPDKRATASDLLQDPFL 268
STKc_DMPK_like cd05597
Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases; ...
223-408 9.00e-35

Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The DMPK-like subfamily is composed of DMPK and DMPK-related cell division control protein 42 (Cdc42) binding kinase (MRCK). DMPK is expressed in skeletal and cardiac muscles, and in central nervous tissues. The functional role of DMPK is not fully understood. It may play a role in the signal transduction and homeostasis of calcium. The DMPK gene is implicated in myotonic dystrophy 1 (DM1), an inherited multisystemic disorder with symptoms that include muscle hyperexcitability, progressive muscle weakness and wasting, cataract development, testicular atrophy, and cardiac conduction defects. The genetic basis for DM1 is the mutational expansion of a CTG repeat in the 3'-UTR of DMPK. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. Three isoforms of MRCK are known, named alpha, beta and gamma. MRCKgamma is expressed in heart and skeletal muscles, unlike MRCKalpha and MRCKbeta, which are expressed ubiquitously. The DMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270748 [Multi-domain]  Cd Length: 331  Bit Score: 132.86  E-value: 9.00e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300
Cdd:cd05597    73 ENYLYLVMDYYCGGDLLTLlsKFEDRLPEEMARFYLAEMVLAIDSIHQLGYVHRDIKPDNVLLDRNGHIRLADFGSCLKL 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 301 EGNDAQLSSTA-GTPAFMAPEAI--SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKN--EAVVFP-E 374
Cdd:cd05597   153 REDGTVQSSVAvGTPDYISPEILqaMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNhkEHFSFPdD 232
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1384865967 375 EPEVSEDLKDLILRMLdKNPETRIG---VSDIKLHPW 408
Cdd:cd05597   233 EDDVSEEAKDLIRRLI-CSRERRLGqngIDDFKKHPF 268
STKc_DAPK2 cd14196
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs ...
128-409 5.37e-34

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK2, also called DAPK-related protein 1 (DRP-1), is a Ca2+/calmodulin (CaM)-regulated protein containing an N-terminal kinase domain, a CaM autoinhibitory site and a dimerization module. It lacks the cytoskeletal binding regions of DAPK1 and the exogenous protein has been shown to be soluble and cytoplasmic. FLAG-tagged DAPK2, however, accumulated within membrane-enclosed autophagic vesicles. It is unclear where endogenous DAPK2 is localized. DAPK2 participates in TNF-alpha and FAS-receptor induced cell death and enhances neutrophilic maturation in myeloid leukemic cells. It contributes to the induction of anoikis and its down-regulation is implicated in the beta-catenin induced resistance of malignant epithelial cells to anoikis. The DAPK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271098 [Multi-domain]  Cd Length: 269  Bit Score: 129.31  E-value: 5.37e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKvlskkkllkqygFPRRpppRGSQATQGGPAKqllplERVYQEIAILKKLD 207
Cdd:cd14196     7 YDIGEELGSGQFAIVKKCREKSTGLEYAAK------------FIKK---RQSRASRRGVSR-----EEIEREVSILRQVL 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd14196    67 HPNIITLHDVYEN--RTDVVLILELVSGGELFDFLAQKeSLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDK 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 G----HVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDyilTLH 362
Cdd:cd14196   145 NipipHIKLIDFGLAHEIE-DGVEFKNIFGTPEFVAPEIVNYEPL---GLEADMWSIGVITYILLSGASPFLGD---TKQ 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 363 RKIKNEAVV---FPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14196   218 ETLANITAVsydFDEEffSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWI 269
STKc_DCKL3 cd14185
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called ...
128-408 1.51e-33

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL3 (or DCAMKL3) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. DCKL3 contains a single DCX domain (instead of a tandem) and a C-terminal kinase domain with similarity to CAMKs. It has been shown to interact with tubulin and JIP1/2. The DCKL3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271087 [Multi-domain]  Cd Length: 258  Bit Score: 127.76  E-value: 1.51e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLlkqygfprrpppRGSQatqggpakqllplERVYQEIAILKKLD 207
Cdd:cd14185     2 YEIGRTIGDGNFAVVKECRHWNENQEYAMKIIDKSKL------------KGKE-------------DMIESEILIIKSLS 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL--G 284
Cdd:cd14185    57 HPNIVKLFEVYETEKE--IYLILEYVRGGDLFDAIIESvKFTEHDAALMIIDLCEALVYIHSKHIVHRDLKPENLLVqhN 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGH--VKIADFGVSNQFEGndaQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPF--IDDYILT 360
Cdd:cd14185   135 PDKSttLKLADFGLAKYVTG---PIFTVCGTPTYVAPEILSEKGY---GLEVDMWAAGVILYILLCGFPPFrsPERDQEE 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384865967 361 LHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14185   209 LFQIIQLGHYEFlpPYWDNISEAAKDLISRLLVVDPEKRYTAKQVLQHPW 258
STKc_MSK_C cd14092
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
198-419 1.52e-33

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270994 [Multi-domain]  Cd Length: 311  Bit Score: 128.96  E-value: 1.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLD-HVNVVKLIEVLDDPAedNLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd14092    47 REVQLLRLCQgHPNIVKLHEVFQDEL--HTYLVMELLRGGELLERIRKKKrFTESEASRIMRQLVSAVSFMHSKGVVHRD 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLL---GDDGHVKIADFGVSnQFEGNDAQLSstagTPAFM----APEAISDSGQSfSG--KALDVWATGVTLYCF 346
Cdd:cd14092   125 LKPENLLFtdeDDDAEIKIVDFGFA-RLKPENQPLK----TPCFTlpyaAPEVLKQALST-QGydESCDLWSLGVILYTM 198
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 347 VYGKCPF----IDDYILTLHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEEPLPS 419
Cdd:cd14092   199 LSGQVPFqspsRNESAAEIMKRIKSGDFSFdgEEWKNVSSEAKSLIQGLLTVDPSKRLTMSELRNHPWLQGSSSPSSTP 277
STKc_PRKX_like cd05612
Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of ...
127-411 2.09e-33

Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. PRKX is present in many tissues including fetal and adult brain, kidney, and lung. The PRKX gene is located in the Xp22.3 subregion and has a homolog called PRKY on the Y chromosome. An abnormal interchange between PRKX aand PRKY leads to the sex reversal disorder of XX males and XY females. PRKX is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PRKX-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270763 [Multi-domain]  Cd Length: 292  Bit Score: 128.32  E-value: 2.09e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKvlskkkllkQYGFPRrppprgsqatqggpAKQLLPLERVYQEIAILKKL 206
Cdd:cd05612     2 DFERIKTIGTGTFGRVHLVRDRISEHYYALK---------VMAIPE--------------VIRLKQEQHVHNEKRVLKEV 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGD 285
Cdd:cd05612    59 SHPFIIRLFWTEHD--QRFLYMLMEYVPGGELFSyLRNSGRFSNSTGLFYASEIVCALEYLHSKEIVYRDLKPENILLDK 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DGHVKIADFGVSNQFEGNDAQLsstAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKI 365
Cdd:cd05612   137 EGHIKLTDFGFAKKLRDRTWTL---CGTPEYLAPEVIQSKGH---NKAVDWWALGILIYEMLVGYPPFFDDNPFGIYEKI 210
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 366 KNEAVVFPEEPEVSedLKDLILRMLDKNPETRI-----GVSDIKLHPWVTK 411
Cdd:cd05612   211 LAGKLEFPRHLDLY--AKDLIKKLLVVDRTRRLgnmknGADDVKNHRWFKS 259
STKc_MAPK cd07834
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs ...
128-422 2.56e-33

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Typical MAPK pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPK kinase (MAP2K or MKK), which itself is phosphorylated and activated by a MAPK kinase kinase (MAP3K or MKKK). Each cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. There are three typical MAPK subfamilies: Extracellular signal-Regulated Kinase (ERK), c-Jun N-terminal Kinase (JNK), and p38. Some MAPKs are atypical in that they are not regulated by MAP2Ks. These include MAPK4, MAPK6, NLK, and ERK7. The MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270828 [Multi-domain]  Cd Length: 329  Bit Score: 128.80  E-value: 2.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLLPLE-------RVYQEI 200
Cdd:cd07834     2 YELLKPIGSGAYGVVCSAYDKRTGRKVAI-------------------------------KKISNVFddlidakRILREI 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 201 AILKKLDHVNVVKLIEVLDDPAEDN---LYLVFDLlrkgpvME------VPCDKPFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd07834    51 KILRHLKHENIIGLLDILRPPSPEEfndVYIVTEL------MEtdlhkvIKSPQPLTDDHIQYFLYQILRGLKYLHSAGV 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG--TPAFMAPEAISDSGQsfSGKALDVWATGVTLYCFVYG 349
Cdd:cd07834   125 IHRDLKPSNILVNSNCDLKICDFGLARGVDPDEDKGFLTEYvvTRWYRAPELLLSSKK--YTKAIDIWSVGCIFAELLTR 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 350 KCPF-----ID--------------------------DYILTL-HRKIKNEAVVFPEEpevSEDLKDLILRMLDKNPETR 397
Cdd:cd07834   203 KPLFpgrdyIDqlnlivevlgtpseedlkfissekarNYLKSLpKKPKKPLSEVFPGA---SPEAIDLLEKMLVFNPKKR 279
                         330       340
                  ....*....|....*....|....*.
gi 1384865967 398 IGVSDIKLHPWVTK-HGEEPLPSEEE 422
Cdd:cd07834   280 ITADEALAHPYLAQlHDPEDEPVAKP 305
STKc_Nek2 cd08217
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
199-407 3.90e-33

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek2 subfamily includes Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants prevented from entering mitosis. NIMA is essential for mitotic entry and progression through mitosis, and its degradation is essential for mitotic exit. NIMA is involved in nuclear membrane fission. Vertebrate Nek2 is a cell cycle-regulated STK, localized in centrosomes and kinetochores, that regulates centrosome splitting at the G2/M phase. It also interacts with other mitotic kinases such as Polo-like kinase 1 and may play a role in spindle checkpoint. An increase in the expression of the human NEK2 gene is strongly associated with the progression of non-Hodgkin lymphoma. Nek2 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. It The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270857 [Multi-domain]  Cd Length: 265  Bit Score: 126.50  E-value: 3.90e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPAEDNLYLVfdllrkgpvMEVpCD---------------KPFPEEQARLYLRDIILGL 263
Cdd:cd08217    49 EVNILRELKHPNIVRYYDRIVDRANTTLYIV---------MEY-CEggdlaqlikkckkenQYIPEEFIWKIFTQLLLAL 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 264 EYLHC-----QKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDsgQSFSGKAlDVWA 338
Cdd:cd08217   119 YECHNrsvggGKILHRDLKPANIFLDSDNNVKLGDFGLARVLSHDSSFAKTYVGTPYYMSPELLNE--QSYDEKS-DIWS 195
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 339 TGvtlyCFVYGKC----PFIDDYILTLHRKIKNEavVFPEEPEV-SEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd08217   196 LG----CLIYELCalhpPFQAANQLELAKKIKEG--KFPRIPSRySSELNEVIKSMLNVDPDKRPSVEELLQLP 263
STKc_ROCK1 cd05622
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
123-408 4.99e-33

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK1 is preferentially expressed in the liver, lung, spleen, testes, and kidney. It mediates signaling from Rho to the actin cytoskeleton. It is implicated in the development of cardiac fibrosis, cardiomyocyte apoptosis, and hyperglycemia. Mice deficient with ROCK1 display eyelids open at birth (EOB) and omphalocele phenotypes due to the disorganization of actin filaments in the eyelids and the umbilical ring. ROCK contains an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain, and is activated via interaction with Rho GTPases. The ROCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270772 [Multi-domain]  Cd Length: 405  Bit Score: 129.74  E-value: 4.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLLPLERV------ 196
Cdd:cd05622    70 MKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAM-------------------------------KLLSKFEMIkrsdsa 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 197 --YQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd05622   119 ffWEERDIMAFANSPWVVQLFYAFQD--DRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHR 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTA-GTPAFMAPEAI-SDSGQSFSGKALDVWATGVTLYCFVYGKCP 352
Cdd:cd05622   197 DVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAvGTPDYISPEVLkSQGGDGYYGRECDWWSVGVFLYEMLVGDTP 276
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 353 FIDDYILTLHRKIKNE--AVVFPEEPEVSEDLKDLILRMLdKNPETRI---GVSDIKLHPW 408
Cdd:cd05622   277 FYADSLVGTYSKIMNHknSLTFPDDNDISKEAKNLICAFL-TDREVRLgrnGVEEIKRHLF 336
STKc_ROCK2 cd05621
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
134-408 7.33e-33

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK2 was the first identified target of activated RhoA, and was found to play a role in stress fiber and focal adhesion formation. It is prominently expressed in the brain, heart, and skeletal muscles. It is implicated in vascular and neurological disorders, such as hypertension and vasospasm of the coronary and cerebral arteries. ROCK2 is also activated by caspase-2 cleavage, resulting in thrombin-induced microparticle generation in response to cell activation. Mice deficient in ROCK2 show intrauterine growth retardation and embryonic lethality because of placental dysfunction. ROCK contains an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain, and is activated via interaction with Rho GTPases. The ROCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270771 [Multi-domain]  Cd Length: 379  Bit Score: 128.96  E-value: 7.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKqygfprrpppRGSQATqggpakqllplerVYQEIAILKKLDHVNVVK 213
Cdd:cd05621    60 IGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIK----------RSDSAF-------------FWEERDIMAFANSPWVVQ 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIAD 293
Cdd:cd05621   117 LFCAFQD--DKYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKYGHLKLAD 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 294 FGVSNQFEGNDAQLSSTA-GTPAFMAPEAI-SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNE--A 369
Cdd:cd05621   195 FGTCMKMDETGMVHCDTAvGTPDYISPEVLkSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHknS 274
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1384865967 370 VVFPEEPEVSEDLKDLILRMLdKNPETRI---GVSDIKLHPW 408
Cdd:cd05621   275 LNFPDDVEISKHAKNLICAFL-TDREVRLgrnGVEEIKQHPF 315
STKc_CCRK cd07832
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the ...
127-410 7.66e-33

Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart, a splice variant of CCRK with a different C-terminal half is expressed; this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270826 [Multi-domain]  Cd Length: 287  Bit Score: 126.67  E-value: 7.66e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKvlskkkllkqygfpRRPPPRGsqatQGGPAKQLLplervyQEIAILKKL 206
Cdd:cd07832     1 RYKILGRIGEGAHGIVFKAKDRETGETVALK--------------KVALRKL----EGGIPNQAL------REIKALQAC 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 -DHVNVVKLIEVLDDPAedNLYLVFDLLRKGpVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd07832    57 qGHPYVVKLRDVFPHGT--GFVLVFEYMLSS-LSEVlrDEERPLTEAQVKRYMRMLLKGVAYMHANRIMHRDLKPANLLI 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 GDDGHVKIADFGVSNQF-EGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGvtlyCfVYG----KCPFID--D 356
Cdd:cd07832   134 SSTGVLKIADFGLARLFsEEDPRLYSHQVATRWYRAPELL--YGSRKYDEGVDLWAVG----C-IFAellnGSPLFPgeN 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 357 YILTLHRKIK-----NE-------------AVVFPEE---------PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd07832   207 DIEQLAIVLRtlgtpNEktwpeltslpdynKITFPESkgirleeifPDCSPEAIDLLKGLLVYNPKKRLSAEEALRHPYF 286

                  .
gi 1384865967 410 T 410
Cdd:cd07832   287 F 287
STKc_PKN cd05589
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer ...
247-407 9.56e-33

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKN has a C-terminal catalytic domain that is highly homologous to PKCs. Its unique N-terminal regulatory region contains antiparallel coiled-coil (ACC) domains. In mammals, there are three PKN isoforms from different genes (designated PKN-alpha, beta, and gamma), which show different enzymatic properties, tissue distribution, and varied functions. PKN can be activated by the small GTPase Rho, and by fatty acids such as arachidonic and linoleic acids. It is involved in many biological processes including cytokeletal regulation, cell adhesion, vesicle transport, glucose transport, regulation of meiotic maturation and embryonic cell cycles, signaling to the nucleus, and tumorigenesis. The PKN subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270741 [Multi-domain]  Cd Length: 326  Bit Score: 127.42  E-value: 9.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 247 FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSg 326
Cdd:cd05589    98 FSEPRAVFYAACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTSTFCGTPEFLAPEVLTDT- 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 327 qSFSgKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVS----- 401
Cdd:cd05589   177 -SYT-RAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPR--FLSTEAISIMRRLLRKNPERRLGASerdae 252

                  ....*.
gi 1384865967 402 DIKLHP 407
Cdd:cd05589   253 DVKKQP 258
STKc_myosinIII_N_like cd06608
N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze ...
194-409 9.98e-33

N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class III myosins are motor proteins with an N-terminal kinase catalytic domain and a C-terminal actin-binding motor domain. Class III myosins are present in the photoreceptors of invertebrates and vertebrates and in the auditory hair cells of mammals. The kinase domain of myosin III can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, and can autophosphorylate the C-terminal motor domain. Myosin III may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. It may also function as a cargo carrier during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The Drosophila class III myosin, called NinaC (Neither inactivation nor afterpotential protein C), is critical in normal adaptation and termination of photoresponse. Vertebrates contain two isoforms of class III myosin, IIIA and IIIB. This subfamily also includes mammalian NIK-like embryo-specific kinase (NESK), Traf2- and Nck-interacting kinase (TNIK), and mitogen-activated protein kinase (MAPK) kinase kinase kinase 4/6. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The class III myosin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270785 [Multi-domain]  Cd Length: 275  Bit Score: 125.88  E-value: 9.98e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKL-DHVNVVKL----IEVLDDPAEDNLYLVFDLLRKGPVMEV-----PCDKPFPEEQARLYLRDIILGL 263
Cdd:cd06608    47 EEIKLEINILRKFsNHPNIATFygafIKKDPPGGDDQLWLVMEYCGGGSVTDLvkglrKKGKRLKEEWIAYILRETLRGL 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 264 EYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQ---SFSGKAlDVWATG 340
Cdd:cd06608   127 AYLHENKVIHRDIKGQNILLTEEAEVKLVDFGVSAQLDSTLGRRNTFIGTPYWMAPEVIACDQQpdaSYDARC-DVWSLG 205
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 341 VTLYCFVYGKCPFIDDYIL-TLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06608   206 ITAIELADGKPPLCDMHPMrALFKIPRNPPPTLKSPEKWSKEFNDFISECLIKNYEQRPFTEELLEHPFI 275
STKc_TSSK3-like cd14163
Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs ...
128-409 1.31e-32

Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. Its mRNA levels is low at birth, increases at puberty, and remains high throughout adulthood. The TSSK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271065 [Multi-domain]  Cd Length: 257  Bit Score: 125.10  E-value: 1.31e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrppprgsqatQGGPA---KQLLPlervyQEIAILK 204
Cdd:cd14163     2 YQLGKTIGEGTYSKVKEAFSKKHQRKVAIKIIDK---------------------SGGPEefiQRFLP-----RELQIVE 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDDpAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd14163    56 RLDHKNIIHVYEMLES-ADGKIYLVMELAEDGDVFDcVLHGGPLPEHRAKALFRQLVEAIRYCHGCGVAHRDLKCENALL 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 -GDDghVKIADFGVSNQFEGNDAQLSST-AGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTL 361
Cdd:cd14163   135 qGFT--LKLTDFGFAKQLPKGGRELSQTfCGSTAYAAPEVL--QGVPHDSRKGDIWSMGVVLYVMLCAQLPFDDTDIPKM 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 362 HRKiKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14163   211 LCQ-QQKGVSLPGHLGVSRTCQDLLKRLLEPDMVLRPSIEEVSWHPWL 257
STKc_DRAK cd14106
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
128-409 1.45e-32

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs, also called STK17, were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. They may play a role in apoptotic signaling. The DRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271008 [Multi-domain]  Cd Length: 268  Bit Score: 125.16  E-value: 1.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSE-IGKGAYGVVRLAYNESEDRHYAmkvlskkkllKQYGFPRRpppRGSQAtqggpakqllpLERVYQEIAILKK- 205
Cdd:cd14106     9 YTVESTpLGRGKFAVVRKCIHKETGKEYA----------AKFLRKRR---RGQDC-----------RNEILHEIAVLELc 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPV-MEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14106    65 KDCPRVVNLHEVYETRSE--LILILELAAGGELqTLLDEEECLTEADVRRLMRQILEGVQYLHERNIVHLDLKPQNILLT 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 ---DDGHVKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFsgkALDVWATGVTLYCFVYGKCPFIDDYILTL 361
Cdd:cd14106   143 sefPLGDIKLCDFGIS-RVIGEGEEIREILGTPDYVAPEILSYEPISL---ATDMWSIGVLTYVLLTGHSPFGGDDKQET 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384865967 362 HRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14106   219 FLNISQCNLDFPEElfKDVSPLAIDFIKRLLVKDPEKRLTAKECLEHPWL 268
STKc_MLCK cd14103
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the ...
194-408 2.44e-32

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module. MLCK2, MLCK3, and MLCK4 share a simpler domain architecture of a single kinase domain near the C-terminus and the absence of Ig-like or FN3 domains. The MLCK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271005 [Multi-domain]  Cd Length: 250  Bit Score: 123.88  E-value: 2.44e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDKPF--PEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd14103    35 EDVRNEIEIMNQLRHPRLLQLYDAFETPRE--MVLVMEYVAGGELFERVVDDDFelTERDCILFMRQICEGVQYMHKQGI 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLL-LGDDGH-VKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAISDSGQSFsgkALDVWATGVTLYCFVYG 349
Cdd:cd14103   113 LHLDLKPENILcVSRTGNqIKIIDFGLARKYDPDK-KLKVLFGTPEFVAPEVVNYEPISY---ATDMWSVGVICYVLLSG 188
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 350 KCPFI-DDYILTLHrKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14103   189 LSPFMgDNDAETLA-NVTRAKWDFDDEafDDISDEAKDFISKLLVKDPRKRMSAAQCLQHPW 249
STKc_ULK1_2-like cd14120
Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar ...
198-407 3.07e-32

Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. ULK2 is ubiquitously expressed and is essential in autophagy induction. ULK1 and ULK2 have unique and cell-type specific roles, but also display partially redundant roles in starvation-induced autophagy. They both display neuron-specific functions: ULK1 is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, and axon branching; ULK2 plays a role in axon development. The ULK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271022 [Multi-domain]  Cd Length: 256  Bit Score: 124.02  E-value: 3.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd14120    41 KEIKILKELSHENVVALLDCQETS--SSVYLVMEYCNGGDLADYLQAKgTLSEDTIRVFLQQIAAAMKALHSKGIVHRDL 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDG---------HVKIADFGVSNQFEGNDaqLSST-AGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCF 346
Cdd:cd14120   119 KPQNILLSHNSgrkpspndiRLKIADFGFARFLQDGM--MAATlCGSPMYMAPEVI--MSLQYDAKA-DLWSIGTIVYQC 193
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 347 VYGKCPFIDDYILTLHRKIKNEAVVFPEEP-EVSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd14120   194 LTGKAPFQAQTPQELKAFYEKNANLRPNIPsGTSPALKDLLLGLLKRNPKDRIDFEDFFSHP 255
STKc_DAPK cd14105
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs ...
128-409 3.09e-32

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. DAPK2 is also called DAPK-related protein 1 (DRP-1), while DAPK3 has also been named DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk). These proteins are ubiquitously expressed in adult tissues, are capable of cross talk with each other, and may act synergistically in regulating cell death. The DAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271007 [Multi-domain]  Cd Length: 269  Bit Score: 124.52  E-value: 3.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKvlskkkllkqygFPRRpppRGSQATQGGPAKqllplERVYQEIAILKKLD 207
Cdd:cd14105     7 YDIGEELGSGQFAVVKKCREKSTGLEYAAK------------FIKK---RRSKASRRGVSR-----EDIEREVSILRQVL 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd14105    67 HPNIITLHDVFENKTD--VVLILELVAGGELFDFLAEKEsLSEEEATEFLKQILDGVNYLHTKNIAHFDLKPENIMLLDK 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 G----HVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDyilTLH 362
Cdd:cd14105   145 NvpipRIKLIDFGLAHKIE-DGNEFKNIFGTPEFVAPEIVNYEPL---GLEADMWSIGVITYILLSGASPFLGD---TKQ 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 363 RKIKNEAVV---FPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14105   218 ETLANITAVnydFDDEyfSNTSELAKDFIRQLLVKDPRKRMTIQESLRHPWI 269
STKc_DCKL1 cd14183
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called ...
126-410 3.41e-32

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL1 (or DCAMKL1) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL1 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL1 interacts with tubulin, glucocorticoid receptor, dynein, JIP1/2, caspases (3 and 8), and calpain, among others. It plays roles in neurogenesis, neuronal migration, retrograde transport, and neuronal apoptosis. The DCKL1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271085 [Multi-domain]  Cd Length: 268  Bit Score: 124.34  E-value: 3.41e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfpRRPPPRGSQatqggpakqllplERVYQEIAILKK 205
Cdd:cd14183     6 ERYKVGRTIGDGNFAVVKECVERSTGREYALKII------------NKSKCRGKE-------------HMIQNEVSILRR 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14183    61 VKHPNIVLLIEEMDMPTE--LYLVMELVKGGDLFDaITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVY 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 D--DG--HVKIADFGVSNQFEGndaQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPF---IDDY 357
Cdd:cd14183   139 EhqDGskSLKLGDFGLATVVDG---PLYTVCGTPTYVAPEIIAETGY---GLKVDIWAAGVITYILLCGFPPFrgsGDDQ 212
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 358 iLTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd14183   213 -EVLFDQILMGQVDFPSPywDNVSDSAKELITMMLQVDVDQRYSALQVLEHPWVN 266
STKc_MEKK4 cd06626
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
134-409 3.64e-32

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK4 is a MAPK kinase kinase that phosphorylates and activates the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. MEKK4 also plays roles in the re-polarization of the actin cytoskeleton in response to osmotic stress, in the proper closure of the neural tube, in cardiovascular development, and in immune responses. The MEKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270796 [Multi-domain]  Cd Length: 265  Bit Score: 123.95  E-value: 3.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrPPPRGSQATqggpakqllpLERVYQEIAILKKLDHVNVVK 213
Cdd:cd06626     8 IGEGTFGKVYTAVNLDTGELMAMKEI--------------RFQDNDPKT----------IKEIADEMKVLEGLDHPNLVR 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 L--IEVlddpAEDNLYL---------VFDLLRKGPVMevpcdkpfPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:cd06626    64 YygVEV----HREEVYIfmeycqegtLEELLRHGRIL--------DEAVIRVYTLQLLEGLAYLHENGIVHRDIKPANIF 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 LGDDGHVKIADFG-----VSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCP--FID 355
Cdd:cd06626   132 LDSNGLIKLGDFGsavklKNNTTTMAPGEVNSLVGTPAYMAPEVITGNKGEGHGRAADIWSLGCVVLEMATGKRPwsELD 211
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 356 DYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06626   212 NEWAIMYHVGMGHKPPIPDSLQLSPEGKDFLSRCLESDPKKRPTASELLDHPFI 265
STKc_HUNK cd14070
Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase ...
198-409 5.05e-32

Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HUNK/MAK-V was identified from a mammary tumor in an MMTV-neu transgenic mouse. It is required for the metastasis of c-myc-induced mammary tumors, but is not necessary for c-myc-induced primary tumor formation or normal development. It is required for HER2/neu-induced tumor formation and maintenance of the cells' tumorigenic phenotype. It is over-expressed in aggressive subsets of ovary, colon, and breast carcinomas. HUNK interacts with synaptopodin, and may also play a role in synaptic plasticity. The HUNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270972 [Multi-domain]  Cd Length: 262  Bit Score: 123.77  E-value: 5.05e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd14070    52 REGRIQQMIRHPNITQLLDILE--TENSYYLVMELCPGGNLMHRIYDKKrLEEREARRYIRQLVSAVEHLHRAGVVHRDL 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSN--QFEGNDAQLSSTAGTPAFMAPEAIsdsGQSFSGKALDVWATGVTLYCFVYGKCPFI 354
Cdd:cd14070   130 KIENLLLDENDNIKLIDFGLSNcaGILGYSDPFSTQCGSPAYAAPELL---ARKKYGPKVDVWSIGVNMYAMLTGTLPFT 206
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 355 DD--YILTLHRKIKNEAVVfPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14070   207 VEpfSLRALHQKMVDKEMN-PLPTDLSPGAISFLRSLLEPDPLKRPNIKQALANRWL 262
STKc_Pat1_like cd13993
Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of ...
128-398 8.83e-32

Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Pat1 (also called Ran1), Saccharomyces cerevisiae VHS1 and KSP1, and similar fungal STKs. Pat1 blocks Mei2, an RNA-binding protein which is indispensable in the initiation of meiosis. Pat1 is inactivated and Mei2 activated, which initiates meiosis, under nutrient-deprived conditions through a signaling cascade involving Ste11. Meiosis induced by Pat1 inactivation may show different characteristics than normal meiosis including aberrant positioning of centromeres. VHS1 was identified in a screen for suppressors of cell cycle arrest at the G1/S transition, while KSP1 may be involved in regulating PRP20, which is required for mRNA export and maintenance of nuclear structure. The Pat1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270895 [Multi-domain]  Cd Length: 267  Bit Score: 122.84  E-value: 8.83e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRgsqatqggpakqllplervYQEIAILKKL- 206
Cdd:cd13993     2 YQLISPIGEGAYGVVYLAVDLRTGRKYAIKCLYKSGPNSKDGNDFQKLPQ-------------------LREIDLHRRVs 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLyLRDIIL----GLEYLHCQKIVHRDIKPSNLL 282
Cdd:cd13993    63 RHPNIITLHDVFET--EVAIYIVLEYCPNGDLFEAITENRIYVGKTEL-IKNVFLqlidAVKHCHSLGIYHRDIKPENIL 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 L-GDDGHVKIADFGVSnqfegNDAQLSSTA--GTPAFMAPEAISD---SGQSFSGKALDVWATGVTLYCFVYGKCPFI-- 354
Cdd:cd13993   140 LsQDEGTVKLCDFGLA-----TTEKISMDFgvGSEFYMAPECFDEvgrSLKGYPCAAGDIWSLGIILLNLTFGRNPWKia 214
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1384865967 355 ---DDYILTLHRKIKNeavVFPEEPEVSEDLKDLILRMLDKNPETRI 398
Cdd:cd13993   215 sesDPIFYDYYLNSPN---LFDVILPMSDDFYNLLRQIFTVNPNNRI 258
STKc_TSSK6-like cd14164
Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs ...
128-409 9.11e-32

Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK6, also called SSTK, is expressed at the head of elongated sperm. It can phosphorylate histones and associate with heat shock protens HSP90 and HSC70. Male mice deficient in TSSK6 are infertile, showing spermatogenic impairment including reduced sperm counts, impaired DNA condensation, abnormal morphology and decreased motility rates. The TSSK6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271066 [Multi-domain]  Cd Length: 256  Bit Score: 122.66  E-value: 9.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfpRRPPPRGSQatqggpakQLLPlervyQEIAILKKLD 207
Cdd:cd14164     2 YTLGTTIGEGSFSKVKLATSQKYCCKVAIKIVDR----------RRASPDFVQ--------KFLP-----RELSILRRVN 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDdPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL-GDD 286
Cdd:cd14164    59 HPNIVQMFECIE-VANGRLYIVMEAAATDLLQKIQEVHHIPKDLARDMFAQMVGAVNYLHDMNIVHRDLKCENILLsADD 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 GHVKIADFGVSNQFEGNdAQLSST-AGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRki 365
Cdd:cd14164   138 RKIKIADFGFARFVEDY-PELSTTfCGSRAYTPPEVI--LGTPYDPKKYDVWSLGVVLYVMVTGTMPFDETNVRRLRL-- 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 366 KNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14164   213 QQRGVLYPSGVALEEPCRALIRTLLQFNPSTRPSIQQVAGNSWL 256
STKc_CASK cd14094
Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein ...
127-409 1.13e-31

Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CASK belongs to the MAGUK (membrane-associated guanylate kinase) protein family, which functions as multiple domain adaptor proteins and is characterized by the presence of a core of three domains: PDZ, SH3, and guanylate kinase (GuK). The enzymatically inactive GuK domain in MAGUK proteins mediates protein-protein interactions and associates intramolecularly with the SH3 domain. In addition, CASK contains a catalytic kinase and two L27 domains. It is highly expressed in the nervous system and plays roles in synaptic protein targeting, neural development, and regulation of gene expression. Binding partners include parkin (a Parkinson's disease molecule), neurexin (adhesion molecule), syndecans, calcium channel proteins, CINAP (nucleosome assembly protein), transcription factor Tbr-1, and the cytoplasmic adaptor proteins Mint1, Veli/mLIN-7/MALS, SAP97, caskin, and CIP98. Deletion or mutations in the CASK gene have been implicated in X-linked mental retardation. The CASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270996 [Multi-domain]  Cd Length: 300  Bit Score: 123.81  E-value: 1.13e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGfprrppprgsqatqggpakqlLPLERVYQEIAILKKL 206
Cdd:cd14094     4 VYELCEVIGKGPFSVVRRCIHRETGQQFAVKIVDVAKFTSSPG---------------------LSTEDLKREASICHML 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDdpAEDNLYLVFDLLRKGP-----VMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNL 281
Cdd:cd14094    63 KHPHIVELLETYS--SDGMLYMVFEFMDGADlcfeiVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCV 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 282 LLG---DDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATGVTLYCFVYGKCPFIDDYI 358
Cdd:cd14094   141 LLAskeNSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVK---REPYGKPVDVWGCGVILFILLSGCLPFYGTKE 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 359 LTLHRKIKNEAVVFPEE-PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14094   218 RLFEGIIKGKYKMNPRQwSHISESAKDLVRRMLMLDPAERITVYEALNHPWI 269
STKc_ULK4 cd14010
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the ...
194-408 1.25e-31

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ULK4 is a functionally uncharacterized kinase that shows similarity to ATG1/ULKs. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. The ULK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270912 [Multi-domain]  Cd Length: 269  Bit Score: 122.79  E-value: 1.25e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEV-PCDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd14010    39 PEVLNEVRLTHELKHPNVLKFYEWYE--TSNHLWLVVEYCTGGDLETLlRQDGNLPESSVRKFGRDLVRGLHYIHSKGII 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTA----------------GTPAFMAPEAISDSGQSFsgkALDV 336
Cdd:cd14010   117 YCDLKPSNILLDGNGTLKLSDFGLARREGEILKELFGQFsdegnvnkvskkqakrGTPYYMAPELFQGGVHSF---ASDL 193
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 337 WATGVTLY-CFVyGKCPFIDDYILTLHRKIKNEAVVFPEEP---EVSEDLKDLILRMLDKNPETRIGVSDIKLHP-W 408
Cdd:cd14010   194 WALGCVLYeMFT-GKPPFVAESFTELVEKILNEDPPPPPPKvssKPSPDFKSLLKGLLEKDPAKRLSWDELVKHPfW 269
STKc_PKD cd14082
Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer ...
186-408 2.02e-31

Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They contain N-terminal cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. The PKD subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270984 [Multi-domain]  Cd Length: 260  Bit Score: 121.75  E-value: 2.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 186 PAKQLlplERVYQEIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLrKGPVMEVPCDKP---FPEEQARLYLRDIILG 262
Cdd:cd14082    42 PTKQE---SQLRNEVAILQQLSHPGVVNLECMFETP--ERVFVVMEKL-HGDMLEMILSSEkgrLPERITKFLVTQILVA 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYLHCQKIVHRDIKPSNLLLGDDG---HVKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWAT 339
Cdd:cd14082   116 LRYLHSKNIVHCDLKPENVLLASAEpfpQVKLCDFGFA-RIIGEKSFRRSVVGTPAYLAPEVLRNKGYN---RSLDMWSV 191
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 340 GVTLYCFVYGKCPFIDDYilTLHRKIKNEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14082   192 GVIIYVSLSGTFPFNEDE--DINDQIQNAAFMYPPNPwkEISPDAIDLINNLLQVKMRKRYSVDKSLSHPW 260
STKc_PKB_beta cd05595
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); ...
244-399 2.59e-31

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-beta is the predominant PKB isoform expressed in insulin-responsive tissues. It plays a critical role in the regulation of glucose homeostasis. It is also implicated in muscle cell differentiation. Mice deficient in PKB-beta display normal growth weights but exhibit severe insulin resistance and diabetes, accompanied by lipoatrophy and B-cell failure. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain.The PKB-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173686 [Multi-domain]  Cd Length: 323  Bit Score: 123.19  E-value: 2.59e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 244 DKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS 323
Cdd:cd05595    89 ERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGITDGATMKTFCGTPEYLAPEVLE 168
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 324 DSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIG 399
Cdd:cd05595   169 DNDY---GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPR--TLSPEAKSLLAGLLKKDPKQRLG 239
STKc_CaMKI_delta cd14168
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
196-409 2.62e-31

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-delta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271070 [Multi-domain]  Cd Length: 301  Bit Score: 122.85  E-value: 2.62e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 196 VYQEIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEVPCDKPF-PEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd14168    55 IENEIAVLRKIKHENIVALEDIYESP--NHLYLVMQLVSGGELFDRIVEKGFyTEKDASTLIRQVLDAVYYLHRMGIVHR 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLL---GDDGHVKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKC 351
Cdd:cd14168   133 DLKPENLLYfsqDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYS---KAVDCWSIGVIAYILLCGYP 208
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 352 PFIDDYILTLHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14168   209 PFYDENDSKLFEQILKADYEFdsPYWDDISDSAKDFIRNLMEKDPNKRYTCEQALRHPWI 268
STYKc smart00221
Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class ...
193-397 3.00e-31

Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.


Pssm-ID: 214568 [Multi-domain]  Cd Length: 258  Bit Score: 121.12  E-value: 3.00e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  193 LERVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGP---VMEVPCDKPFPEEQARLYLRDIILGLEYLHCQ 269
Cdd:smart00221  45 IEEFLREARIMRKLDHPNIVKLLGVCTE--EEPLMIVMEYMPGGDlldYLRKNRPKELSLSDLLSFALQIARGMEYLESK 122
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  270 KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAISDSgqSFSGKAlDVWATGVTLY-CFV 347
Cdd:smart00221 123 NFIHRDLAARNCLVGENLVVKISDFGLSRDLYDDDYYKVKGGKLPiRWMAPESLKEG--KFTSKS-DVWSFGVLLWeIFT 199
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1384865967  348 YGKCPFIDDYILTLHRKIKNEAVVfPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:smart00221 200 LGEEPYPGMSNAEVLEYLKKGYRL-PKPPNCPPELYKLMLQCWAEDPEDR 248
STKc_TLK cd13990
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the ...
194-408 4.11e-31

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270892 [Multi-domain]  Cd Length: 279  Bit Score: 121.66  E-value: 4.11e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDdpaednlylvFDLLRKGPVMEVpCD-----------KPFPEEQARLYLRDIILG 262
Cdd:cd13990    49 KHALREYEIHKSLDHPRIVKLYDVFE----------IDTDSFCTVLEY-CDgndldfylkqhKSIPEREARSIIMQVVSA 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYL--HCQKIVHRDIKPSNLLLGDD---GHVKIADFGVSNQFEGNDA-----QLSST-AGTPAFMAPEA--ISDSGQSF 329
Cdd:cd13990   118 LKYLneIKPPIIHYDLKPGNILLHSGnvsGEIKITDFGLSKIMDDESYnsdgmELTSQgAGTYWYLPPECfvVGKTPPKI 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 330 SGKaLDVWATGVTLYCFVYGKCPFIDDY----ILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKL 405
Cdd:cd13990   198 SSK-VDVWSVGVIFYQMLYGRKPFGHNQsqeaILEENTILKATEVEFPSKPVVSSEAKDFIRRCLTYRKEDRPDVLQLAN 276

                  ...
gi 1384865967 406 HPW 408
Cdd:cd13990   277 DPY 279
STKc_SLK cd06643
Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer ...
193-410 5.34e-31

Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It acts as a MAPK kinase kinase by phosphorylating ASK1, resulting in the phosphorylation of p38. SLK also plays a role in mediating actin reorganization. It is part of a microtubule-associated complex that is targeted at adhesion sites, and is required in focal adhesion turnover and in regulating cell migration. The SLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270811 [Multi-domain]  Cd Length: 283  Bit Score: 121.29  E-value: 5.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQK 270
Cdd:cd06643    46 LEDYMVEIDILASCDHPNIVKLLDAF--YYENNLWILIEFCAGGAVDAVmlELERPLTEPQIRVVCKQTLEALVYLHENK 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI---SDSGQSFSGKAlDVWATGVTLYCFV 347
Cdd:cd06643   124 IIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTLQRRDSFIGTPYWMAPEVVmceTSKDRPYDYKA-DVWSLGVTLIEMA 202
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 348 YGKCPFIDDYILTLHRKI-KNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd06643   203 QIEPPHHELNPMRVLLKIaKSEPPTLAQPSRWSPEFKDFLRKCLEKNVDARWTTSQLLQHPFVS 266
STKc_GAK_like cd13985
Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of ...
133-403 6.27e-31

Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes cyclin G-Associated Kinase (GAK), Drosophila melanogaster Numb-Associated Kinase (NAK)-like proteins, and similar protein kinases. GAK plays regulatory roles in clathrin-mediated membrane trafficking, the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses. NAK plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. The GAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270887 [Multi-domain]  Cd Length: 272  Bit Score: 120.90  E-value: 6.27e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 133 EIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQygfprrppprgsqatqggpakqllplERVYQEIAILKKL-DHVNV 211
Cdd:cd13985     7 QLGEGGFSYVYLAHDVNTGRRYALKRMYFNDEEQL--------------------------RVAIKEIEIMKRLcGHPNI 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 212 VKLI--EVLDDPAEDNLYLVFDLLRKGPV--MEVPCDKPFPEEQARLYLRDIILGLEYLHCQK--IVHRDIKPSNLLLGD 285
Cdd:cd13985    61 VQYYdsAILSSEGRKEVLLLMEYCPGSLVdiLEKSPPSPLSEEEVLRIFYQICQAVGHLHSQSppIIHRDIKIENILFSN 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DGHVKIADFG-VSNQF-EGNDAQLSSTA-------GTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDD 356
Cdd:cd13985   141 TGRFKLCDFGsATTEHyPLERAEEVNIIeeeiqknTTPMYRAPEMIDLYSKKPIGEKADIWALGCLLYKLCFFKLPFDES 220
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1384865967 357 YILtlhrKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd13985   221 SKL----AIVAGKYSIPEQPRYSPELHDLIRHMLTPDPAERPDIFQV 263
TyrKc smart00219
Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.
129-397 6.41e-31

Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.


Pssm-ID: 197581 [Multi-domain]  Cd Length: 257  Bit Score: 120.33  E-value: 6.41e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  129 KLQSEIGKGAYGVVRLAynesedrhyamkvlskkkllkqygfprrppprgsQATQGGPA-------KQLLP------LER 195
Cdd:smart00219   2 TLGKKLGEGAFGEVYKG----------------------------------KLKGKGGKkkvevavKTLKEdaseqqIEE 47
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  196 VYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:smart00219  48 FLREARIMRKLDHPNVVKLLGVCTE--EEPLYIVMEYMEGGDLLSYlrKNRPKLSLSDLLSFALQIARGMEYLESKNFIH 125
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  274 RDIKPSNLLLGDDGHVKIADFGVSNqfEGNDAQLSSTAGTP---AFMAPEAISDSgqSFSGKAlDVWATGVTLY-CFVYG 349
Cdd:smart00219 126 RDLAARNCLVGENLVVKISDFGLSR--DLYDDDYYRKRGGKlpiRWMAPESLKEG--KFTSKS-DVWSFGVLLWeIFTLG 200
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1384865967  350 KCPFIDDYILTLHRKIKNEAVVfPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:smart00219 201 EQPYPGMSNEEVLEYLKNGYRL-PQPPNCPPELYDLMLQCWAEDPEDR 247
STKc_NAK1_like cd06917
Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
127-422 6.56e-31

Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Nak1, Saccharomyces cerevisiae Kic1p (kinase that interacts with Cdc31p) and related proteins. Nak1 (also called N-rich kinase 1), is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Kic1p is required by budding yeast for cell integrity and morphogenesis. Kic1p interacts with Cdc31p, the yeast homologue of centrin, and phosphorylates substrates in a Cdc31p-dependent manner. The Nak1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270822 [Multi-domain]  Cd Length: 277  Bit Score: 121.04  E-value: 6.56e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQygfprrppprgsqatqggpakqllpLERVYQEIAILKKL 206
Cdd:cd06917     2 LYRRLELVGRGSYGAVYRGYHVKTGRVVALKVLNLDTDDDD-------------------------VSDIQKEVALLSQL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIE----VLDDPaedNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:cd06917    57 KLGQPKNIIKyygsYLKGP---SLWIIMDYCEGGSIRTLMRAGPIAERYIAVIMREVLVALKFIHKDGIIHRDIKAANIL 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 LGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDsGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDyilTLH 362
Cdd:cd06917   134 VTNTGNVKLCDFGVAASLNQNSSKRSTFVGTPYWMAPEVITE-GKYYDTKA-DIWSLGITTYEMATGNPPYSDV---DAL 208
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 363 RKI----KNEAVVFPEEpEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEEPLPSEEE 422
Cdd:cd06917   209 RAVmlipKSKPPRLEGN-GYSPLLKEFVAACLDEEPKDRLSADELLKSKWIKQHSKTPTSVLKE 271
STKc_MRCK_alpha cd05623
Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 ...
223-410 7.98e-31

Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-alpha is expressed ubiquitously in many tissues. It plays a role in the regulation of peripheral actin reorganization and neurite outgrowth. It may also play a role in the transferrin iron uptake pathway. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270773 [Multi-domain]  Cd Length: 409  Bit Score: 123.59  E-value: 7.98e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300
Cdd:cd05623   144 DNNLYLVMDYYVGGDLLTLlsKFEDRLPEDMARFYLAEMVLAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKL 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 301 -EGNDAQLSSTAGTPAFMAPEAIS--DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKN--EAVVFPEE 375
Cdd:cd05623   224 mEDGTVQSSVAVGTPDYISPEILQamEDGKGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNhkERFQFPTQ 303
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1384865967 376 -PEVSEDLKDLILRMLDKNpETRI---GVSDIKLHPWVT 410
Cdd:cd05623   304 vTDVSENAKDLIRRLICSR-EHRLgqnGIEDFKNHPFFV 341
STKc_CNK2-like cd08530
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar ...
127-407 8.04e-31

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii CNK2 has both cilliary and cell cycle functions. It influences flagellar length through promoting flagellar disassembly, and it regulates cell size, through influencing the size threshold at which cells commit to mitosis. This subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily includes CNK1, and -2. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270869 [Multi-domain]  Cd Length: 256  Bit Score: 120.19  E-value: 8.04e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLlkqygfprrppprgSQATQggpakqllplERVYQEIAILKKL 206
Cdd:cd08530     1 DFKVLKKLGKGSYGSVYKVKRLSDNQVYALKEVNLGSL--------------SQKER----------EDSVNEIRLLASV 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEV-LDDpaeDNLYLV---------FDLLRKGPVMEvpcdKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd08530    57 NHPNIIRYKEAfLDG---NRLCIVmeyapfgdlSKLISKRKKKR----RLFPEDDIWRIFIQMLRGLKALHDQKILHRDL 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAISDSGQSFSGkalDVWATGVTLYCFVYGKCPFIDD 356
Cdd:cd08530   130 KSANILLSAGDLVKIGDLGISKVLKKNLAK--TQIGTPLYAAPEVWKGRPYDYKS---DIWSLGCLLYEMATFRPPFEAR 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 357 YILTLHRKIKNEAvvFPEEPEV-SEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd08530   205 TMQELRYKVCRGK--FPPIPPVySQDLQQIIRSLLQVNPKKRPSCDKLLQSP 254
STKc_DAPK3 cd14195
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs ...
128-409 8.09e-31

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK3, also called DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk), contains an N-terminal kinase domain and a C-terminal region with nuclear localization signals (NLS) and a leucine zipper motif that mediates homodimerization and interaction with other leucine zipper proteins. It interacts with Par-4, a protein that contains a death domain and interacts with actin filaments. DAPK3 is present in both the cytoplasm and nucleus. Its co-expression with Par-4 results in the co-localization of the two proteins to actin filaments. In addition to cell death, DAPK3 is also implicated in mediating cell motility and the contraction of smooth muscles. The DAPK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271097 [Multi-domain]  Cd Length: 271  Bit Score: 120.49  E-value: 8.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKvlskkkllkqygFPRRpppRGSQATQGGPAKqllplERVYQEIAILKKLD 207
Cdd:cd14195     7 YEMGEELGSGQFAIVRKCREKGTGKEYAAK------------FIKK---RRLSSSRRGVSR-----EEIEREVNILREIQ 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd14195    67 HPNIITLHDIFEN--KTDVVLILELVSGGELFDFLAEKeSLTEEEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDK 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 G----HVKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDyilTLH 362
Cdd:cd14195   145 NvpnpRIKLIDFGIAHKIEAGN-EFKNIFGTPEFVAPEIVNYEPL---GLEADMWSIGVITYILLSGASPFLGE---TKQ 217
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 363 RKIKNEAVV---FPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14195   218 ETLTNISAVnydFDEEyfSNTSELAKDFIRRLLVKDPKKRMTIAQSLEHSWI 269
STKc_MRCK_beta cd05624
Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control ...
223-408 1.32e-30

Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-beta is expressed ubiquitously in many tissues. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270774 [Multi-domain]  Cd Length: 409  Bit Score: 123.20  E-value: 1.32e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300
Cdd:cd05624   144 ENYLYLVMDYYVGGDLLTLlsKFEDKLPEDMARFYIGEMVLAIHSIHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLKM 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 301 EGNDAQLSSTA-GTPAFMAPEAIS--DSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKN--EAVVFPEE 375
Cdd:cd05624   224 NDDGTVQSSVAvGTPDYISPEILQamEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNheERFQFPSH 303
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1384865967 376 -PEVSEDLKDLILRMLDKNpETRI---GVSDIKLHPW 408
Cdd:cd05624   304 vTDVSEEAKDLIQRLICSR-ERRLgqnGIEDFKKHAF 339
STKc_RSK1_C cd14175
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called ...
198-416 1.47e-30

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK1 is also called S6K-alpha-1, RPS6KA1, p90RSK1 or MAPK-activated protein kinase 1a (MAPKAPK-1a). It is a component of the insulin transduction pathway, regulating the function of IRS1. It also interacts with PKA and promotes its inactivation. RSK1 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271077 [Multi-domain]  Cd Length: 291  Bit Score: 120.52  E-value: 1.47e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKL-DHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd14175    43 EEIEILLRYgQHPNIITLKDVYDD--GKHVYLVTELMRGGELLDkILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRD 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLL----GDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKC 351
Cdd:cd14175   121 LKPSNILYvdesGNPESLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD---EGCDIWSLGILLYTMLAGYT 197
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 352 PFID------DYILTlhrKIKNEAVVFP--EEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEEP 416
Cdd:cd14175   198 PFANgpsdtpEEILT---RIGSGKFTLSggNWNTVSDAAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDKLP 267
STKc_SGK cd05575
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; ...
134-407 2.87e-30

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGKs are activated by insulin and growth factors via phosphoinositide 3-kinase and PDK1. They activate ion channels, ion carriers, and the Na-K-ATPase, as well as regulate the activity of enzymes and transcription factors. SGKs play important roles in transport, hormone release, neuroexcitability, cell proliferation, and apoptosis. There are three isoforms of SGK, named SGK1, SGK2, and SGK3 (also called cytokine-independent survival kinase CISK). The SGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270727 [Multi-domain]  Cd Length: 323  Bit Score: 120.11  E-value: 2.87e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpakqllpleRVYQEIAILKK--LDHV-- 209
Cdd:cd05575     3 IGKGSFGKVLLARHKAEGKLYAV--------------------------------------KVLQKKAILKRneVKHIma 44
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 210 --NVvkLIEVLDDP----------AEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd05575    45 erNV--LLKNVKHPflvglhysfqTKDKLYFVLDYVNGGELFfHLQRERHFPEPRARFYAAEIASALGYLHSLNIIYRDL 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQ-FEGNDAQlSSTAGTPAFMAPEAISDsgQSFsGKALDVWATGVTLYCFVYGKCPFID 355
Cdd:cd05575   123 KPENILLDSQGHVVLTDFGLCKEgIEPSDTT-STFCGTPEYLAPEVLRK--QPY-DRTVDWWCLGAVLYEMLYGLPPFYS 198
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 356 DYILTLHRKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVS----DIKLHP 407
Cdd:cd05575   199 RDTAEMYDNILHKPLRLR--TNVSPSARDLLEGLLQKDRTKRLGSGndflEIKNHS 252
STKc_CDK4_6_like cd07838
Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; ...
128-409 3.86e-30

Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 and CDK6 partner with D-type cyclins to regulate the early G1 phase of the cell cycle. They are the first kinases activated by mitogenic signals to release cells from the G0 arrested state. CDK4 and CDK6 are both expressed ubiquitously, associate with all three D cyclins (D1, D2 and D3), and phosphorylate the retinoblastoma (pRb) protein. They are also regulated by the INK4 family of inhibitors which associate with either the CDK alone or the CDK/cyclin complex. CDK4 and CDK6 show differences in subcellular localization, sensitivity to some inhibitors, timing in activation, tumor selectivity, and possibly substrate profiles. Although CDK4 and CDK6 seem to show some redundancy, they also have discrete, nonoverlapping functions. CDK6 plays an important role in cell differentiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4/6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270831 [Multi-domain]  Cd Length: 287  Bit Score: 118.92  E-value: 3.86e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLlplervyQEIAILKKLD 207
Cdd:cd07838     1 YEEVAEIGEGAYGTVYKARDLQDGRFVALKKV-----------------RVPLSEEGIPLSTI-------REIALLKQLE 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 ---HVNVVKLIEVLDDPAEDN---LYLVF-----DL---LRKgpvmevpCDKP-FPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd07838    57 sfeHPNVVRLLDVCHGPRTDRelkLTLVFehvdqDLatyLDK-------CPKPgLPPETIKDLMRQLLRGLDFLHSHRIV 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATGvtlycfvygkCP 352
Cdd:cd07838   130 HRDLKPQNILVTSDGQVKLADFGLARIYSFEMA-LTSVVVTLWYRAPEVLL---QSSYATPVDMWSVG----------CI 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 353 FIDDYILT-----------LHrKI-------------KNEAVV---FPEE---------PEVSEDLKDLILRMLDKNPET 396
Cdd:cd07838   196 FAELFNRRplfrgsseadqLG-KIfdviglpseeewpRNSALPrssFPSYtprpfksfvPEIDEEGLDLLKKMLTFNPHK 274
                         330
                  ....*....|...
gi 1384865967 397 RIGVSDIKLHPWV 409
Cdd:cd07838   275 RISAFEALQHPYF 287
STKc_GRK1 cd05608
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs ...
134-407 4.12e-30

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK1 (also called rhodopsin kinase) belongs to the visual group of GRKs and is expressed in retinal cells. It phosphorylates rhodopsin in rod cells, which leads to termination of the phototransduction cascade. Mutations in GRK1 are associated to a recessively inherited form of stationary nightblindness called Oguchi disease. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270759 [Multi-domain]  Cd Length: 288  Bit Score: 118.83  E-value: 4.12e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFprrppprgsqatqggpakqllplERVYQEIAILKKLDHVNVVK 213
Cdd:cd05608     9 LGKGGFGEVSACQMRATGKLYACKKLNKKRLKKRKGY-----------------------EGAMVEKRILAKVHSRFIVS 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDPAEdnLYLVFDLLRKGP----VMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGH 288
Cdd:cd05608    66 LAYAFQTKTD--LCLVMTIMNGGDlryhIYNVDEENPgFQEPRACFYTAQIISGLEHLHQRRIIYRDLKPENVLLDDDGN 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 289 VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCPF------IDDYILTlh 362
Cdd:cd05608   144 VRISDLGLAVELKDGQTKTKGYAGTPGFMAPELLLGEEYDYS---VDYFTLGVTLYEMIAARGPFrargekVENKELK-- 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384865967 363 RKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSD-----IKLHP 407
Cdd:cd05608   219 QRILNDSVTYSE--KFSPASKSICEALLAKDPEKRLGFRDgncdgLRTHP 266
STKc_OSR1_SPAK cd06610
Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and ...
126-407 4.90e-30

Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SPAK is also referred to as STK39 or PASK (proline-alanine-rich STE20-related kinase). OSR1 and SPAK regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. They are also implicated in cytoskeletal rearrangement, cell differentiation, transformation and proliferation. OSR1 and SPAK contain a conserved C-terminal (CCT) domain, which recognizes a unique motif ([RK]FX[VI]) present in their activating kinases (WNK1/WNK4) and their substrates. The OSR1 and SPAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270787 [Multi-domain]  Cd Length: 267  Bit Score: 118.23  E-value: 4.90e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygFPRRPPPrgsqatqggpakqllpLERVYQEIAILKK 205
Cdd:cd06610     1 DDYELIEVIGSGATAVVYAAYCLPKKEKVAIKRID---------LEKCQTS----------------MDELRKEIQAMSQ 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVK----LIEvlddpaEDNLYLVFDLLRKGPVMEV-----PCDKpFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd06610    56 CNHPNVVSyytsFVV------GDELWLVMPLLSGGSLLDImkssyPRGG-LDEAIIATVLKEVLKGLEYLHSNGQIHRDV 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVS-NQFEGNDAQ---LSSTAGTPAFMAPEAISdSGQSFSGKAlDVWATGVTLYCFVYGKCP 352
Cdd:cd06610   129 KAGNILLGEDGSVKIADFGVSaSLATGGDRTrkvRKTFVGTPCWMAPEVME-QVRGYDFKA-DIWSFGITAIELATGAAP 206
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 353 FiDDY--ILTLHRKIKNEAVVFPEEPEV---SEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd06610   207 Y-SKYppMKVLMLTLQNDPPSLETGADYkkySKSFRKMISLCLQKDPSKRPTAEELLKHK 265
STKc_MAP4K3_like cd06613
Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like ...
127-409 4.96e-30

Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAP4K3, MAP4K1, MAP4K2, MAP4K5, and related proteins. Vertebrate members contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K1, also called haematopoietic progenitor kinase 1 (HPK1), is a hematopoietic-specific STK involved in many cellular signaling cascades including MAPK, antigen receptor, apoptosis, growth factor, and cytokine signaling. It participates in the regulation of T cell receptor signaling and T cell-mediated immune responses. MAP4K2 was referred to as germinal center (GC) kinase because of its preferred location in GC B cells. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. It is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). The MAP4K3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270788 [Multi-domain]  Cd Length: 259  Bit Score: 117.79  E-value: 4.96e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVrlaynesedrhyamkvlskkkllkqygFPRRPPPRGSQAtqggpAKQLLPLER------VYQEI 200
Cdd:cd06613     1 DYELIQRIGSGTYGDV---------------------------YKARNIATGELA-----AVKVIKLEPgddfeiIQQEI 48
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 201 AILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVPC-DKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPS 279
Cdd:cd06613    49 SMLKECRHPNIVAYFGSYL--RRDKLWIVMEYCGGGSLQDIYQvTGPLSELQIAYVCRETLKGLAYLHSTGKIHRDIKGA 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 280 NLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS-DSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYI 358
Cdd:cd06613   127 NILLTEDGDVKLADFGVSAQLTATIAKRKSFIGTPYWMAPEVAAvERKGGYDGKC-DIWALGITAIELAELQPPMFDLHP 205
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 359 ---LTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06613   206 mraLFLIPKSNFDPPKLKDKEKWSPDFHDFIKKCLTKNPKKRPTATKLLQHPFV 259
STKc_Bck1_like cd06629
Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein ...
134-409 5.52e-30

Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Saccharomyces cerevisiae Bck1 and Schizosaccharomyces pombe Mkh1, and related proteins. Budding yeast Bck1 is part of the cell integrity MAPK pathway, which is activated by stresses and aggressions to the cell wall. The MAPKKK Bck1, MAPKKs Mkk1 and Mkk2, and the MAPK Slt2 make up the cascade that is important in the maintenance of cell wall homeostasis. Fission yeast Mkh1 is involved in MAPK cascades regulating cell morphology, cell wall integrity, salt resistance, and filamentous growth in response to stress. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The Bck1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270799 [Multi-domain]  Cd Length: 270  Bit Score: 118.25  E-value: 5.52e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKvlskkkllkQYGFPRRPPPRGSQatqggpaKQLLPLERVYQEIAILKKLDHVNVVK 213
Cdd:cd06629     9 IGKGTYGRVYLAMNATTGEMLAVK---------QVELPKTSSDRADS-------RQKTVVDALKSEIDTLKDLDHPNIVQ 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDPAEDNLYL-------VFDLLRKgpvmevpcDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd06629    73 YLGFEETEDYFSIFLeyvpggsIGSCLRK--------YGKFEEDLVRFFTRQILDGLAYLHSKGILHRDLKADNILVDLE 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 GHVKIADFGVSNQFE---GNDAQLSSTaGTPAFMAPEAISDSGQSFSGKaLDVWATGVTLYCFVYGKCPFIDDYILTLHR 363
Cdd:cd06629   145 GICKISDFGISKKSDdiyGNNGATSMQ-GSVFWMAPEVIHSQGQGYSAK-VDIWSLGCVVLEMLAGRRPWSDDEAIAAMF 222
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 364 KI--KNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06629   223 KLgnKRSAPPVPEDVNLSPEALDFLNACFAIDPRDRPTAAELLSHPFL 270
STKc_Mnk2 cd14173
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
128-409 1.07e-29

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271075 [Multi-domain]  Cd Length: 288  Bit Score: 117.82  E-value: 1.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEI-GKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPpprgsqatqgGPAKQllpleRVYQEIAILKKL 206
Cdd:cd14173     3 YQLQEEVlGEGAYARVQTCINLITNKEYAVKI-----------IEKRP----------GHSRS-----RVFREVEMLYQC 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 D-HVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14173    57 QgHRNVLELIEFFEE--EDKFYLVFEKMRGGSILsHIHRRRHFNELEASVVVQDIASALDFLHNKGIAHRDLKPENILCE 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGH---VKIADFGVSNQFEGND-------AQLSSTAGTPAFMAPEAIS--DSGQSFSGKALDVWATGVTLYCFVYGKCP 352
Cdd:cd14173   135 HPNQvspVKICDFDLGSGIKLNSdcspistPELLTPCGSAEYMAPEVVEafNEEASIYDKRCDLWSLGVILYIMLSGYPP 214
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 353 FID--------DY-------ILTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14173   215 FVGrcgsdcgwDRgeacpacQNMLFESIQEGKYEFPEKdwAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 288
STKc_YPK1_like cd05585
Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the ...
199-411 1.37e-29

Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal proteins with similarity to the AGC STKs, Saccharomyces cerevisiae YPK1 and Schizosaccharomyces pombe Gad8p. YPK1 is required for cell growth and acts as a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. It also plays a role in efficient endocytosis and in the maintenance of cell wall integrity. Gad8p is a downstream target of Tor1p, the fission yeast homolog of mTOR. It plays a role in cell growth and sexual development. The YPK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270737 [Multi-domain]  Cd Length: 313  Bit Score: 118.06  E-value: 1.37e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd05585    44 ERTVLAQVDCPFIVPLKFSFQSP--EKLYLVLAFINGGELFhHLQREGRFDLSRARFYTAELLCALECLHKFNVIYRDLK 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 278 PSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPFIDDY 357
Cdd:cd05585   122 PENILLDYTGHIALCDFGLCKLNMKDDDKTNTFCGTPEYLAPELLLGHGYT---KAVDWWTLGVLLYEMLTGLPPFYDEN 198
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 358 ILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGV---SDIKLHPWVTK 411
Cdd:cd05585   199 TNEMYRKILQEPLRFPD--GFDRDAKDLLIGLLNRDPTKRLGYngaQEIKNHPFFDQ 253
STKc_MLCK1 cd14191
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze ...
194-409 2.06e-29

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK1 (or MYLK1) phosphorylates myosin regulatory light chain and controls the contraction of smooth muscles. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module which results in the expression of telokin in phasic smooth muscles, leading to Ca2+ desensitization by cyclic nucleotides of smooth muscle force. MLCK1 is also responsible for myosin regulatory light chain phosphorylation in nonmuscle cells and may play a role in regulating myosin II ATPase activity. The MLCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271093 [Multi-domain]  Cd Length: 259  Bit Score: 116.26  E-value: 2.06e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAedNLYLVFDLLRKGPVMEVPCDKPF--PEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd14191    44 ENIRQEISIMNCLHHPKLVQCVDAFEEKA--NIVMVLEMVSGGELFERIIDEDFelTERECIKYMRQISEGVEYIHKQGI 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDD--GHVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAISDSGQSFsgkALDVWATGVTLYCFVYG 349
Cdd:cd14191   122 VHLDLKPENIMCVNKtgTKIKLIDFGLARRLE-NAGSLKVLFGTPEFVAPEVINYEPIGY---ATDMWSIGVICYILVSG 197
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 350 KCPFIDDYILTLHRKIKNEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14191   198 LSPFMGDNDNETLANVTSATWDFDDEAfdEISDDAKDFISNLLKKDMKARLTCTQCLQHPWL 259
STKc_PLK2 cd14188
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the ...
194-406 2.34e-29

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK2, also called Snk (serum-inducible kinase), functions in G1 progression, S-phase arrest, and centriole duplication. Its gene is responsive to both growth factors and cellular stress, is a transcriptional target of p53, and activates a G2-M checkpoint. The PLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271090 [Multi-domain]  Cd Length: 255  Bit Score: 115.88  E-value: 2.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLL-RKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd14188    46 EKIDKEIELHRILHHKHVVQFYHYFED--KENIYILLEYCsRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEIL 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCP 352
Cdd:cd14188   124 HRDLKLGNFFINENMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGH---GCESDIWALGCVMYTMLLGRPP 200
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 353 FIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLH 406
Cdd:cd14188   201 FETTNLKETYRCIREARYSLPS--SLLAPAKHLIASMLSKNPEDRPSLDEIIRH 252
STKc_nPKC_theta cd05619
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze ...
223-408 2.40e-29

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. Although T-cells also express other PKC isoforms, PKC-theta is unique in that upon antigen stimulation, it is translocated to the plasma membrane at the immunological synapse, where it mediates signals essential for T-cell activation. It is essential for TCR-induced proliferation, cytokine production, T-cell survival, and the differentiation and effector function of T-helper (Th) cells, particularly Th2 and Th17. PKC-theta is being developed as a therapeutic target for Th2-mediated allergic inflammation and Th17-mediated autoimmune diseases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270770 [Multi-domain]  Cd Length: 331  Bit Score: 118.10  E-value: 2.40e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVME--VPCDKpFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF 300
Cdd:cd05619    78 KENLFFVMEYLNGGDLMFhiQSCHK-FDLPRATFYAAEIICGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKEN 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 301 EGNDAQLSSTAGTPAFMAPEAIsdSGQSFsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSE 380
Cdd:cd05619   157 MLGDAKTSTFCGTPDYIAPEIL--LGQKY-NTSVDWWSFGVLLYEMLIGQSPFHGQDEEELFQSIRMDNPFYPR--WLEK 231
                         170       180
                  ....*....|....*....|....*....
gi 1384865967 381 DLKDLILRMLDKNPETRIGV-SDIKLHPW 408
Cdd:cd05619   232 EAKDILVKLFVREPERRLGVrGDIRQHPF 260
STKc_RSK3_C cd14178
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called ...
128-409 2.97e-29

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK3 is also called S6K-alpha-2, RPS6KA2, p90RSK2 or MAPK-activated protein kinase 1c (MAPKAPK-1c). RSK3 binds muscle A-kinase anchoring protein (mAKAP)-b directly and regulates concentric cardiac myocyte growth. The RSK3 gene, RPS6KA2, is a putative tumor suppressor gene in sporadic epithelial ovarian cancer and variations to the gene may be associated with rectal cancer risk. RSK3 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271080 [Multi-domain]  Cd Length: 293  Bit Score: 116.65  E-value: 2.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKkllkqygfpRRPPPrgsqatqggpakqllplervyQEIAILKKL- 206
Cdd:cd14178     5 YEIKEDIGIGSYSVCKRCVHKATSTEYAVKIIDKS---------KRDPS---------------------EEIEILLRYg 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL-- 283
Cdd:cd14178    55 QHPNIITLKDVYDD--GKFVYLVMELMRGGELLDrILRQKCFSEREASAVLCTITKTVEYLHSQGVVHRDLKPSNILYmd 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 --GDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPFI---DDYI 358
Cdd:cd14178   133 esGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYD---AACDIWSLGILLYTMLAGFTPFAngpDDTP 209
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 359 LTLHRKIKNE--AVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14178   210 EEILARIGSGkyALSGGNWDSISDAAKDIVSKMLHVDPHQRLTAPQVLRHPWI 262
STKc_MEKK1 cd06630
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
183-407 3.63e-29

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK1 is a MAPK kinase kinase (MAPKKK or MKKK) that phosphorylates and activates activates the ERK1/2 and c-Jun N-terminal kinase (JNK) pathways by activating their respective MAPKKs, MEK1/2 and MKK4/MKK7, respectively. MEKK1 is important in regulating cell survival and apoptosis. MEKK1 also plays a role in cell migration, tissue maintenance and homeostasis, and wound healing. The MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270800 [Multi-domain]  Cd Length: 268  Bit Score: 115.99  E-value: 3.63e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 183 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLievLDDPAEDNLYLVFDLLRKGPVMEVPCDK--PFPEEQARLYLRDII 260
Cdd:cd06630    37 RNSSSEQEEVVEAIREEIRMMARLNHPNIVRM---LGATQHKSHFNIFVEWMAGGSVASLLSKygAFSENVIINYTLQIL 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 261 LGLEYLHCQKIVHRDIKPSNLLLGDDG-HVKIADFGVSNQ----------FEGndaQLsstAGTPAFMAPEAIsdSGQSF 329
Cdd:cd06630   114 RGLAYLHDNQIIHRDLKGANLLVDSTGqRLRIADFGAAARlaskgtgageFQG---QL---LGTIAFMAPEVL--RGEQY 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 330 sGKALDVWATGVTLYCFVYGKCPFIDDYI---LTLHRKIKNeAVVFPEEPE-VSEDLKDLILRMLDKNPETRIGVSDIKL 405
Cdd:cd06630   186 -GRSCDVWSVGCVIIEMATAKPPWNAEKIsnhLALIFKIAS-ATTPPPIPEhLSPGLRDVTLRCLELQPEDRPPARELLK 263

                  ..
gi 1384865967 406 HP 407
Cdd:cd06630   264 HP 265
STKc_RSK2_C cd14176
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called ...
112-416 3.85e-29

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK2 is also called p90RSK3, RPS6KA3, S6K-alpha-3, or MAPK-activated protein kinase 1b (MAPKAPK-1b). RSK2 is expressed highly in the regions of the brain with high synaptic activity. It plays a role in the maintenance and consolidation of excitatory synapses. It is a specific modulator of phospholipase D in calcium-regulated exocytosis. Mutations in the RSK2 gene, RPS6KA3, cause Coffin-Lowry syndrome (CLS), a rare syndromic form of X-linked mental retardation characterized by growth and psychomotor retardation and skeletal abnormalities. RSK2 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271078 [Multi-domain]  Cd Length: 339  Bit Score: 117.43  E-value: 3.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 112 HRVAISDTEdcvqlnQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKkllkqygfpRRPPPrgsqatqggpakqll 191
Cdd:cd14176    11 HRNSIQFTD------GYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKS---------KRDPT--------------- 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 192 plervyQEIAILKKL-DHVNVVKLIEVLDDPAedNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQ 269
Cdd:cd14176    61 ------EEIEILLRYgQHPNIITLKDVYDDGK--YVYVVTELMKGGELLDkILRQKFFSEREASAVLFTITKTVEYLHAQ 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 270 KIVHRDIKPSNLLLGDDG----HVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYC 345
Cdd:cd14176   133 GVVHRDLKPSNILYVDESgnpeSIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQGYD---AACDIWSLGVLLYT 209
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 346 FVYGKCPFI---DDYILTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEEP 416
Cdd:cd14176   210 MLTGYTPFAngpDDTPEEILARIGSGKFSLSGGywNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLP 285
STKc_GRK4_like cd05605
Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs ...
247-408 4.49e-29

Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the GRK4-like group include GRK4, GRK5, GRK6, and similar GRKs. They contain an N-terminal RGS homology (RH) domain and a catalytic domain, but lack a G protein betagamma-subunit binding domain. They are localized to the plasma membrane through post-translational lipid modification or direct binding to PIP2. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270756 [Multi-domain]  Cd Length: 285  Bit Score: 115.92  E-value: 4.49e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 247 FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAISDSG 326
Cdd:cd05605    99 FEEERAVFYAAEITCGLEHLHSERIVYRDLKPENILLDDHGHVRISDLGLAVEIPEGET-IRGRVGTVGYMAPEVVKNER 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 327 QSFSgkaLDVWATGVTLYCFVYGKCPFiddyiLTLHRKIKNEAV--VFPEEPEV-----SEDLKDLILRMLDKNPETRIG 399
Cdd:cd05605   178 YTFS---PDWWGLGCLIYEMIEGQAPF-----RARKEKVKREEVdrRVKEDQEEysekfSEEAKSICSQLLQKDPKTRLG 249
                         170
                  ....*....|....
gi 1384865967 400 -----VSDIKLHPW 408
Cdd:cd05605   250 crgegAEDVKSHPF 263
STKc_Mnk1 cd14174
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
128-409 4.76e-29

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271076 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 4.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEI-GKGAYGVVRLAYNESEDRHYAMKVLSKkkllkQYGFPRrppprgsqatqggpakqllplERVYQEIAILKKL 206
Cdd:cd14174     3 YRLTDELlGEGAYAKVQGCVSLQNGKEYAVKIIEK-----NAGHSR---------------------SRVFREVETLYQC 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 D-HVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14174    57 QgNKNILELIEFFEDDTR--FYLVFEKLRGGSILaHIQKRKHFNEREASRVVRDIASALDFLHTKGIAHRDLKPENILCE 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGH---VKIADFGVSNQFEGNDA-------QLSSTAGTPAFMAPEAIS--DSGQSFSGKALDVWATGVTLYCFVYGKCP 352
Cdd:cd14174   135 SPDKvspVKICDFDLGSGVKLNSActpittpELTTPCGSAEYMAPEVVEvfTDEATFYDKRCDLWSLGVILYIMLSGYPP 214
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 353 FIDDYIL---------------TLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14174   215 FVGHCGTdcgwdrgevcrvcqnKLFESIQEGKYEFPDKdwSHISSEAKDLISKLLVRDAKERLSAAQVLQHPWV 288
STKc_NDR2 cd05627
Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2; STKs catalyze ...
125-408 4.81e-29

Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR2 (also called STK38-like) plays a role in proper centrosome duplication. In addition, it is involved in regulating neuronal growth and differentiation, as well as in facilitating neurite outgrowth. NDR2 is also implicated in fear conditioning as it contributes to the coupling of neuronal morphological changes with fear-memory consolidation. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270776 [Multi-domain]  Cd Length: 366  Bit Score: 117.85  E-value: 4.81e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKkllkqygfprrppprgsqatqggpakQLLPLERVYQ---EIA 201
Cdd:cd05627     1 LDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKA--------------------------DMLEKEQVAHiraERD 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 202 ILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSN 280
Cdd:cd05627    55 ILVEADGAWVVKMFYSFQD--KRNLYLIMEFLPGGDMMTLLMKKdTLSEEATQFYIAETVLAIDAIHQLGFIHRDIKPDN 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 281 LLLGDDGHVKIADFGV----------------------------------SNQFEGNDAQLS-STAGTPAFMAPEAISDS 325
Cdd:cd05627   133 LLLDAKGHVKLSDFGLctglkkahrtefyrnlthnppsdfsfqnmnskrkAETWKKNRRQLAySTVGTPDYIAPEVFMQT 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 326 GQSfsgKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKN--EAVVFPEEPEVSEDLKDLILRMLdKNPETRIG---V 400
Cdd:cd05627   213 GYN---KLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNwkETLVFPPEVPISEKAKDLILRFC-TDAENRIGsngV 288

                  ....*...
gi 1384865967 401 SDIKLHPW 408
Cdd:cd05627   289 EEIKSHPF 296
STKc_CDK9_like cd07840
Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs ...
128-340 5.32e-29

Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes, yeast BUR1, C-type plant CDKs (CdkC), and similar proteins. CDK9, BUR1, and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2, and participates in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270832 [Multi-domain]  Cd Length: 291  Bit Score: 115.74  E-value: 5.32e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLlplervyQEIAILKKLD 207
Cdd:cd07840     1 YEKIAQIGEGTYGQVYKARNKKTGELVALKKI-----------------RMENEKEGFPITAI-------REIKLLQKLD 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPAED----NLYLVFD--------LLRKGPVmevpcdkPFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd07840    57 HPNVVRLKEIVTSKGSAkykgSIYMVFEymdhdltgLLDNPEV-------KFTESQIKCYMKQLLEGLQYLHSNGILHRD 129
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 276 IKPSNLLLGDDGHVKIADFGVSNQFEG-NDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATG 340
Cdd:cd07840   130 IKGSNILINNDGVLKLADFGLARPYTKeNNADYTNRVITLWYRPPELL--LGATRYGPEVDMWSVG 193
STKc_PAK_II cd06648
Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze ...
133-409 5.68e-29

Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group II PAKs, also called non-conventional PAKs, include PAK4, PAK5, and PAK6. Group II PAKs contain PBD (p21-binding domain) and catalytic domains, but lack other motifs found in group I PAKs, such as an AID (autoinhibitory domain) and SH3 binding sites. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. While group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX, no such binding has been demonstrated for group II PAKs. Some known substrates of group II PAKs are also substrates of group I PAKs such as Raf, BAD, LIMK and GEFH1. Unique group II substrates include MARK/Par-1 and PDZ-RhoGEF. Group II PAKs play important roles in filopodia formation, neuron extension, cytoskeletal organization, and cell survival. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270815 [Multi-domain]  Cd Length: 261  Bit Score: 115.23  E-value: 5.68e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 133 EIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLkqygfpRRppprgsqatqggpakqllplERVYQEIAILKKLDHVNVV 212
Cdd:cd06648    14 KIGEGSTGIVCIATDKSTGRQVAVKKMDLRKQQ------RR--------------------ELLFNEVVIMRDYQHPNIV 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 213 KLIEVLddPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd06648    68 EMYSSY--LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCRAVLKALSFLHSQGVIHRDIKSDSILLTSDGRVKLS 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIK-NEAVV 371
Cdd:cd06648   146 DFGFCAQVSKEVPRRKSLVGTPYWMAPEVIS---RLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMKRIRdNEPPK 222
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1384865967 372 FPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06648   223 LKNLHKVSPRLRSFLDRMLVRDPAQRATAAELLNHPFL 260
STKc_STK33 cd14097
Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the ...
128-409 5.85e-29

Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK33 is highly expressed in the testis and is present in low levels in most tissues. It may be involved in spermatogenesis and organ ontogenesis. It interacts with and phosphorylates vimentin and may be involved in regulating intermediate filament cytoskeletal dynamics. Its role in promoting the cell viability of KRAS-dependent cancer cells is under debate; some studies have found STK33 to promote cancer cell viability, while other studies have found it to be non-essential. KRAS is the most commonly mutated human oncogene, thus, studies on the role of STK33 in KRAS mutant cancer cells are important. The STK33 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270999 [Multi-domain]  Cd Length: 266  Bit Score: 115.34  E-value: 5.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrpPPRGSQATQggpakqllPLERvyqEIAILKKLD 207
Cdd:cd14097     3 YTFGRKLGQGSFGVVIEATHKETQTKWAIKKINR-------------EKAGSSAVK--------LLER---EVDILKHVN 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL--- 283
Cdd:cd14097    59 HAHIIHLEEVFETPKR--MYLVMELCEDGELKELLLRKGfFSENETRHIIQSLASAVAYLHKNDIVHRDLKLENILVkss 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 ----GDDGHVKIADFGVSNQFEG-NDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPFIDDYI 358
Cdd:cd14097   137 iidnNDKLNIKVTDFGLSVQKYGlGEDMLQETCGTPIYMAPEVISAHGYS---QQCDIWSIGVIMYMLLCGEPPFVAKSE 213
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 359 LTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14097   214 EKLFEEIRKGDLTFTQSvwQSVSDAAKNVLQQLLKVDPAHRMTASELLDNPWI 266
STKc_RSK_N cd05582
N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; ...
195-407 6.90e-29

N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), p90-RSKs, or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270734 [Multi-domain]  Cd Length: 317  Bit Score: 116.35  E-value: 6.90e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 195 RVYQEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVM-----EVPcdkpFPEEQARLYLRDIILGLEYLHCQ 269
Cdd:cd05582    43 RTKMERDILADVNHPFIVKLHYAFQ--TEGKLYLILDFLRGGDLFtrlskEVM----FTEEDVKFYLAELALALDHLHSL 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 270 KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGkalDVWATGVTLYCFVYG 349
Cdd:cd05582   117 GIIYRDLKPENILLDEDGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSA---DWWSFGVLMFEMLTG 193
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 350 KCPFIDDYILTLHRKIKNEAVVFPE--EPEVSedlkdLILRMLDK-NPETRIG-----VSDIKLHP 407
Cdd:cd05582   194 SLPFQGKDRKETMTMILKAKLGMPQflSPEAQ-----SLLRALFKrNPANRLGagpdgVEEIKRHP 254
STKc_MEKK3_like cd06625
Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) ...
134-409 7.27e-29

Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MEKK3, MEKK2, and related proteins; all contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKK) that activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270795 [Multi-domain]  Cd Length: 260  Bit Score: 114.76  E-value: 7.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKvlskkkllkqygfpRRPPPRGSQATQggpaKQLLPLERvyqEIAILKKLDHVNVVK 213
Cdd:cd06625     8 LGQGAFGQVYLCYDADTGRELAVK--------------QVEIDPINTEAS----KEVKALEC---EIQLLKNLQHERIVQ 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDpaEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd06625    67 YYGCLQD--EKSLSIFMEYMPGGSVKdEIKAYGALTENVTRKYTRQILEGLAYLHSNMIVHRDIKGANILRDSNGNVKLG 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGVSNQFEGNDAQ--LSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAV 370
Cdd:cd06625   145 DFGASKRLQTICSStgMKSVTGTPYWMSPEVI--NGEGYGRKA-DIWSVGCTVVEMLTTKPPWAEFEPMAAIFKIATQPT 221
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1384865967 371 VFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06625   222 NPQLPPHVSEDARDFLSLIFVRNKKQRPSAEELLSHSFV 260
STKc_nPKC_delta cd05620
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze ...
223-418 8.35e-29

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173710 [Multi-domain]  Cd Length: 316  Bit Score: 116.20  E-value: 8.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
Cdd:cd05620    68 KEHLFFVMEFLNGGDLMFHIQDKgRFDLYRATFYAAEIVCGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENV 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSED 381
Cdd:cd05620   148 FGDNRASTFCGTPDYIAPEILQGLKYTFS---VDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPR--WITKE 222
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 382 LKDLILRMLDKNPETRIGVS-DIKLHP------WVTKHGEEPLP 418
Cdd:cd05620   223 SKDILEKLFERDPTRRLGVVgNIRGHPffktinWTALEKRELDP 266
STKc_RSK4_C cd14177
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called ...
128-416 9.94e-29

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK4 is also called S6K-alpha-6, RPS6KA6, p90RSK6 or pp90RSK4. RSK4 is a substrate of ERK and is a modulator of p53-dependent proliferation arrest in human cells. Deletion of the RSK4 gene, RPS6KA6, frequently occurs in patients of X-linked deafness type 3, mental retardation and choroideremia. Studies of RSK4 in cancer cells and tissues suggest that it may be oncogenic or tumor suppressive depending on many factors. RSK4 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271079 [Multi-domain]  Cd Length: 295  Bit Score: 115.50  E-value: 9.94e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKkllkqygfpRRPPPrgsqatqggpakqllplervyQEIAILKKL- 206
Cdd:cd14177     6 YELKEDIGVGSYSVCKRCIHRATNMEFAVKIIDKS---------KRDPS---------------------EEIEILMRYg 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGD 285
Cdd:cd14177    56 QHPNIITLKDVYDDGRY--VYLVTELMKGGELLDrILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDLKPSNILYMD 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DG----HVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPFI---DDYI 358
Cdd:cd14177   134 DSanadSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMRQGYD---AACDIWSLGVLLYTMLAGYTPFAngpNDTP 210
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 359 LTLHRKIKNEAVVFP--EEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEEP 416
Cdd:cd14177   211 EEILLRIGSGKFSLSggNWDTVSDAAKDLLSHMLHVDPHQRYTAEQVLKHSWIACRDQLP 270
STKc_Twitchin_like cd14114
The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs ...
125-409 1.11e-28

The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. Twitchin and Projectin are both associated with thick filaments. Twitchin is localized in the outer parts of A-bands and is involved in regulating muscle contraction. It interacts with the myofibrillar proteins myosin and actin in a phosphorylation-dependent manner, and may be involved in regulating the myosin cross-bridge cycle. The kinase activity of Twitchen is activated by Ca2+ and the Ca2+ binding protein S100A1. Projectin is associated with the end of thick filaments and is a component of flight muscle connecting filaments. The kinase domain of Projectin may play roles in autophosphorylation and transphosphorylation, which impact the formation of myosin filaments. The Twitchin-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271016 [Multi-domain]  Cd Length: 259  Bit Score: 114.22  E-value: 1.11e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKvlskkkllkqygFPRRPPPrgsqatqggpakqlLPLERVYQEIAILK 204
Cdd:cd14114     1 YDHYDILEELGTGAFGVVHRCTERATGNNFAAK------------FIMTPHE--------------SDKETVRKEIQIMN 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKPF--PEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:cd14114    55 QLHHPKLINLHDAFED--DNEMVLILEFLSGGELFERIAAEHYkmSEAEVINYMRQVCEGLCHMHENNIVHLDIKPENIM 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 L--GDDGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCPFIDDYILT 360
Cdd:cd14114   133 CttKRSNEVKLIDFGLATHLDPKES-VKVTTGTAEFAAPEIVEREPVGFY---TDMWAVGVLSYVLLSGLSPFAGENDDE 208
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 361 LHRKIKNEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14114   209 TLRNVKSCDWNFDDSAfsGISEEAKDFIRKLLLADPNKRMTIHQALEHPWL 259
STKc_MSK1_N cd05613
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
223-421 1.25e-28

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270764 [Multi-domain]  Cd Length: 290  Bit Score: 115.10  E-value: 1.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
Cdd:cd05613    77 DTKLHLILDYINGGELFtHLSQRERFTENEVQIYIGEIVLALEHLHKLGIIYRDIKLENILLDSSGHVVLTDFGLSKEFL 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 302 GNDAQLS-STAGTPAFMAPEaISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDD----YILTLHRKIKNEAVVFPEep 376
Cdd:cd05613   157 LDENERAySFCGTIEYMAPE-IVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDgeknSQAEISRRILKSEPPYPQ-- 233
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384865967 377 EVSEDLKDLILRMLDKNPETRIG-----VSDIKLHPWVTKHGEEPLPSEE 421
Cdd:cd05613   234 EMSALAKDIIQRLLMKDPKKRLGcgpngADEIKKHPFFQKINWDDLAAKK 283
STKc_FA2-like cd08529
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar ...
128-407 1.64e-28

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii FA2 was discovered in a genetic screen for deflagellation-defective mutants. It is essential for basal-body/centriole-associated microtubule severing, and plays a role in cell cycle progression. No cellular function has yet been ascribed to CNK4. The Chlamydomonas reinhardtii FA2-like subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily contains FA2 and CNK4. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270868 [Multi-domain]  Cd Length: 256  Bit Score: 113.66  E-value: 1.64e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKkllkqygfprrpppRGSQATQggpakqllplERVYQEIAILKKLD 207
Cdd:cd08529     2 FEILNKLGKGSFGVVYKVVRKVDGRVYALKQIDIS--------------RMSRKMR----------EEAIDEARVLSKLN 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEV---PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd08529    58 SPYVIKYYDSFVD--KGKLNIVMEYAENGDLHSLiksQRGRPLPEDQIWKFFIQTLLGLSHLHSKKILHRDIKSMNIFLD 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDsgQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLHRK 364
Cdd:cd08529   136 KGDNVKIGDLGVAKILSDTTNFAQTIVGTPYYLSPELCED--KPYNEKS-DVWALGCVLYELCTGKHPFEAQNQGALILK 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1384865967 365 IKnEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd08529   213 IV-RGKYPPISASYSQDLSQLIDSCLTKDYRQRPDTTELLRNP 254
STKc_GRK cd05577
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs ...
199-407 2.43e-28

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. GRKs play important roles in the cardiovascular, immune, respiratory, skeletal, and nervous systems. They contain a central catalytic domain, flanked by N- and C-terminal extensions. The N-terminus contains an RGS (regulator of G protein signaling) homology (RH) domain and several motifs. The C-terminus diverges among different groups of GRKs. There are seven types of GRKs, named GRK1 to GRK7, which are subdivided into three main groups: visual (GRK1/7); beta-adrenergic receptor kinases (GRK2/3); and GRK4-like (GRK4/5/6). Expression of GRK2/3/5/6 is widespread while GRK1/4/7 show a limited tissue distribution. The substrate spectrum of the widely expressed GRKs partially overlaps. The GRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270729 [Multi-domain]  Cd Length: 278  Bit Score: 113.78  E-value: 2.43e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPV------MEVPCdkpFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd05577    43 EKIILEKVSSPFIVSLAYAFETK--DKLCLVLTLMNGGDLkyhiynVGTRG---FSEARAIFYAAEIICGLEHLHNRFIV 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNdAQLSSTAGTPAFMAPEAISDsGQSFSGKAlDVWATGVTLYCFVYGKCP 352
Cdd:cd05577   118 YRDLKPENILLDDHGHVRISDLGLAVEFKGG-KKIKGRVGTHGYMAPEVLQK-EVAYDFSV-DWFALGCMLYEMIAGRSP 194
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 353 FIDDYILT----LHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIG-----VSDIKLHP 407
Cdd:cd05577   195 FRQRKEKVdkeeLKRRTLEMAVEYPD--SFSPEARSLCEGLLQKDPERRLGcrggsADEVKEHP 256
STKc_ULK1 cd14202
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the ...
198-409 3.17e-28

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. It associates with three autophagy-related proteins (Atg13, FIP200 amd Atg101) to form the ULK1 complex. All fours proteins are essential for autophagosome formation. ULK1 is regulated by both mammalian target-of rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK). mTORC1 negatively regulates the ULK1 complex in a nutrient-dependent manner while AMPK stimulates autophagy by inhibiting mTORC1. ULK1 also plays neuron-specific roles and is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, neurite extension, and axon branching. The ULK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271104 [Multi-domain]  Cd Length: 267  Bit Score: 113.18  E-value: 3.17e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd14202    50 KEIKILKELKHENIVALYDFQE--IANSVYLVMEYCNGGDLADyLHTMRTLSEDTIRLFLQQIAGAMKMLHSKGIIHRDL 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDG---------HVKIADFGVSNQFEGNdAQLSSTAGTPAFMAPEAISDsgQSFSGKAlDVWATGVTLYCFV 347
Cdd:cd14202   128 KPQNILLSYSGgrksnpnniRIKIADFGFARYLQNN-MMAATLCGSPMYMAPEVIMS--QHYDAKA-DLWSIGTIIYQCL 203
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 348 YGKCPFIDDYILTLHRKIKNEAVVFPEEP-EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14202   204 TGKAPFQASSPQDLRLFYEKNKSLSPNIPrETSSHLRQLLLGLLQRNQKDRMDFDEFFHHPFL 266
PK_Tyr_Ser-Thr pfam07714
Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role ...
198-397 3.21e-28

Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyze the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyze the reverse process. Protein kinases fall into three broad classes, characterized with respect to substrate specificity; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.


Pssm-ID: 462242 [Multi-domain]  Cd Length: 258  Bit Score: 112.98  E-value: 3.21e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEV--LDDPaednLYLVFDLLRKGPVME--VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:pfam07714  50 EEASIMKKLDHPNIVKLLGVctQGEP----LYIVTEYMPGGDLLDflRKHKRKLTLKDLLSMALQIAKGMEYLESKNFVH 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG-TPAF-MAPEAISDSgqSFSGKAlDVWATGVTLY-CFVYGK 350
Cdd:pfam07714 126 RDLAARNCLVSENLVVKISDFGLSRDIYDDDYYRKRGGGkLPIKwMAPESLKDG--KFTSKS-DVWSFGVLLWeIFTLGE 202
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 351 CPFIDdyiltlhrkIKNEAVVF-------PEEPEV-SEDLKDLILRMLDKNPETR 397
Cdd:pfam07714 203 QPYPG---------MSNEEVLEfledgyrLPQPENcPDELYDLMKQCWAYDPEDR 248
PKc_Pek1_like cd06621
Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
262-409 3.26e-28

Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Pek1/Skh1 from Schizosaccharomyces pombe and MKK2 from Saccharomyces cerevisiae, and related proteins. Both fission yeast Pek1 and baker's yeast MKK2 are components of the cell integrity MAPK pathway. In fission yeast, Pek1 phosphorylates and activates Pmk1/Spm1 and is regulated by the MAPKK kinase Mkh1. In baker's yeast, the pathway involves the MAPK Slt2, the MAPKKs MKK1 and MKK2, and the MAPKK kinase Bck1. The cell integrity MAPK cascade is activated by multiple stress conditions, and is essential in cell wall construction, morphogenesis, cytokinesis, and ion homeostasis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270793 [Multi-domain]  Cd Length: 287  Bit Score: 113.67  E-value: 3.26e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAqlSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGV 341
Cdd:cd06621   117 GLSYLHSRKIIHRDIKPSNILLTRKGQVKLCDFGVSGELVNSLA--GTFTGTSYYMAPERI--QGGPYSITS-DVWSLGL 191
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 342 TLYCFVYGKCPFIDDYI-----LTLHRKIKNEAV-VFPEEPEV----SEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06621   192 TLLEVAQNRFPFPPEGEpplgpIELLSYIVNMPNpELKDEPENgikwSESFKDFIEKCLEKDGTRRPGPWQMLAHPWI 269
STKc_Nek10 cd08528
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
199-397 3.35e-28

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. No function has yet been ascribed to Nek10. The gene encoding Nek10 is a putative causative gene for breast cancer; it is located within a breast cancer susceptibility loci on chromosome 3p24. Nek10 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270867 [Multi-domain]  Cd Length: 270  Bit Score: 113.37  E-value: 3.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILK-KLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEV-----PCDKPFPEEQARLYLRDIILGLEYLHCQK-I 271
Cdd:cd08528    58 EVNIIKeQLRHPNIVRYYKTFLE--NDRLYIVMELIEGAPLGEHfsslkEKNEHFTEDRIWNIFVQMVLALRYLHKEKqI 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdsgQSFS-GKALDVWATGVTLYCFVYGK 350
Cdd:cd08528   136 VHRDLKPNNIMLGEDDKVTITDFGLAKQKGPESSKMTSVVGTILYSCPEIV----QNEPyGEKADIWALGCILYQMCTLQ 211
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 351 CPFIDDYILTLHRKIKNeAVVFP-EEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd08528   212 PPFYSTNMLTLATKIVE-AEYEPlPEGMYSDDITFVIRSCLTPDPEAR 258
STKc_Aurora-B_like cd14117
Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs ...
198-418 4.56e-28

Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). This subfamily includes Aurora-B and Aurora-C. Aurora-B is most active at the transition during metaphase to the end of mitosis. It associates with centromeres, relocates to the midzone of the central spindle, and concentrates at the midbody during cell division. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. INCENP participates in the activation of Aurora-B in a two-step process: first by binding to form an intermediate state of activation and the phosphorylation of its C-terminal TSS motif to generate the fully active kinase. The Aurora-B subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271019 [Multi-domain]  Cd Length: 270  Bit Score: 112.65  E-value: 4.56e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd14117    55 REIEIQSHLRHPNILRLYNYFHD--RKRIYLILEYAPRGELYkELQKHGRFDEQRTATFMEELADALHYCHEKKVIHRDI 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSnqFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKaLDVWATGVTLYCFVYGKCPFIDD 356
Cdd:cd14117   133 KPENLLMGYKGELKIADFGWS--VHAPSLRRRTMCGTLDYLPPEMI--EGRTHDEK-VDLWCIGVLCYELLVGMPPFESA 207
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 357 YILTLHRKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEEPLP 418
Cdd:cd14117   208 SHTETYRRIVKVDLKFP--PFLSDGSRDLISKLLRYHPSERLPLKGVMEHPWVKANSRRVLP 267
STKc_ERK5 cd07855
Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; ...
127-424 6.78e-28

Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ERK5 (also called Big MAPK1 (BMK1) or MAPK7) has a unique C-terminal extension, making it approximately twice as big as other MAPKs. This extension contains transcriptional activation capability which is inhibited by the N-terminal half. ERK5 is activated in response to growth factors and stress by a cascade that leads to its phosphorylation by the MAP2K MEK5, which in turn is regulated by the MAP3Ks MEKK2 and MEKK3. Activated ERK5 phosphorylates its targets including myocyte enhancer factor 2 (MEF2), Sap1a, c-Myc, and RSK. It plays a role in EGF-induced cell proliferation during the G1/S phase transition. Studies on knockout mice revealed that ERK5 is essential for cardiovascular development and plays an important role in angiogenesis. It is also critical for neural differentiation and survival. The ERK5 pathway has been implicated in the pathogenesis of many diseases including cancer, cardiac hypertrophy, and atherosclerosis. MAPKs are important mediators of cellular responses to extracellular signals. The ERK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270842 [Multi-domain]  Cd Length: 336  Bit Score: 114.00  E-value: 6.78e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprRPPPRGSQATQGgpAKqllpleRVYQEIAILKKL 206
Cdd:cd07855     6 RYEPIETIGSGAYGVVCSAIDTKSGQKVAI----------------KKIPNAFDVVTT--AK------RTLRELKILRHF 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAE----DNLYLVFDLlrkgpvME------VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd07855    62 KHDNIIAIRDILRPKVPyadfKDVYVVLDL------MEsdlhhiIHSDQPLTLEHIRYFLYQLLRGLKYIHSANVIHRDL 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQ----LSSTAGTPAFMAPEAISdSGQSFSgKALDVWATG------------ 340
Cdd:cd07855   136 KPSNLLVNENCELKIGDFGMARGLCTSPEEhkyfMTEYVATRWYRAPELML-SLPEYT-QAIDMWSVGcifaemlgrrql 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 341 ---------VTLYCFVYGKCP--FIDD--------YILTL-HRKIKNEAVVFpeePEVSEDLKDLILRMLDKNPETRIGV 400
Cdd:cd07855   214 fpgknyvhqLQLILTVLGTPSqaVINAigadrvrrYIQNLpNKQPVPWETLY---PKADQQALDLLSQMLRFDPSERITV 290
                         330       340
                  ....*....|....*....|....
gi 1384865967 401 SDIKLHPWVTKHgeePLPSEEEHC 424
Cdd:cd07855   291 AEALQHPFLAKY---HDPDDEPDC 311
STKc_GRK6 cd05630
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs ...
199-407 7.93e-28

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK6 is widely expressed in many tissues and is expressed as multiple splice variants with different domain architectures. It is post-translationally palmitoylated and localized in the membrane. GRK6 plays important roles in the regulation of dopamine, M3 muscarinic, opioid, and chemokine receptor signaling. It also plays maladaptive roles in addiction and Parkinson's disease. GRK6-deficient mice exhibit altered dopamine receptor regulation, decreased lymphocyte chemotaxis, and increased acute inflammation and neutrophil chemotaxis. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270779 [Multi-domain]  Cd Length: 285  Bit Score: 112.42  E-value: 7.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPV---MEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd05630    50 EKQILEKVNSRFVVSLAYAYE--TKDALCLVLTLMNGGDLkfhIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRD 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLLGDDGHVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAISDSGQSFSGkalDVWATGVTLYCFVYGKCPFID 355
Cdd:cd05630   128 LKPENILLDDHGHIRISDLGLAVHVP-EGQTIKGRVGTVGYMAPEVVKNERYTFSP---DWWALGCLLYEMIAGQSPFQQ 203
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 356 DyiltlHRKIKNEAV--VFPEEPE-----VSEDLKDLILRMLDKNPETRIG-----VSDIKLHP 407
Cdd:cd05630   204 R-----KKKIKREEVerLVKEVPEeysekFSPQARSLCSMLLCKDPAERLGcrgggAREVKEHP 262
STKc_MLCK3 cd14192
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze ...
194-409 9.98e-28

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK3 (or MYLK3) phosphorylates myosin regulatory light chain 2 and controls the contraction of cardiac muscles. It is expressed specifically in both the atrium and ventricle of the heart and its expression is regulated by the cardiac protein Nkx2-5. MLCK3 plays an important role in cardiogenesis by regulating the assembly of cardiac sarcomeres, the repeating contractile unit of striated muscle. MLCK3 contains a single kinase domain near the C-terminus and a unique N-terminal half, and unlike MLCK1/2, it does not appear to be regulated by Ca2+/calmodulin. The MLCK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271094 [Multi-domain]  Cd Length: 261  Bit Score: 111.59  E-value: 9.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVPCDKPF--PEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd14192    46 EEVKNEINIMNQLNHVNLIQLYDAFE--SKTNLTLIMEYVDGGELFDRITDESYqlTELDAILFTRQICEGVHYLHQHYI 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLL-LGDDGH-VKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAISDSGQSFsgkALDVWATGVTLYCFVYG 349
Cdd:cd14192   124 LHLDLKPENILcVNSTGNqIKIIDFGLARRYKPRE-KLKVNFGTPEFLAPEVVNYDFVSF---PTDMWSVGVITYMLLSG 199
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 350 KCPFIDDYILTLHRKIKNEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14192   200 LSPFLGETDAETMNNIVNCKWDFDAEAfeNLSEEAKDFISRLLVKEKSCRMSATQCLKHEWL 261
STKc_myosinIIIA_N cd06638
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze ...
126-409 1.07e-27

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIA myosin is highly expressed in retina and in inner ear hair cells. It is localized to the distal ends of actin-bundled structures. Mutations in human myosin IIIA are responsible for progressive nonsyndromic hearing loss. Human myosin IIIA possesses ATPase and kinase activities, and the ability to move actin filaments in a motility assay. It may function as a cellular transporter capable of moving along actin bundles in sensory cells. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. Class III myosins may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. In photoreceptor cells, they may also function as cargo carriers during light-dependent translocation of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132969 [Multi-domain]  Cd Length: 286  Bit Score: 112.03  E-value: 1.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEdrhyamkvlskkkllkqygfprrppprGSQATqggpAKQLLPLERVYQEIA---- 201
Cdd:cd06638    18 DTWEIIETIGKGTYGKVFKVLNKKN---------------------------GSKAA----VKILDPIHDIDEEIEaeyn 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 202 ILKKL-DHVNVVKLIEVL---DDPAEDNLYLVFDLLRKGPVMEVPcdKPFPEEQARL-------YLRDIILGLEYLHCQK 270
Cdd:cd06638    67 ILKALsDHPNVVKFYGMYykkDVKNGDQLWLVLELCNGGSVTDLV--KGFLKRGERMeepiiayILHEALMGLQHLHVNK 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQ--SFSGKALDVWATGVTLYCFVY 348
Cdd:cd06638   145 TIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQldSTYDARCDVWSLGITAIELGD 224
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 349 GKCPFIDDYILTLHRKIKNEAVVFPEEPEV-SEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06638   225 GDPPLADLHPMRALFKIPRNPPPTLHQPELwSNEFNDFIRKCLTKDYEKRPTVSDLLQHVFI 286
STKc_obscurin_rpt1 cd14107
Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
168-408 1.33e-27

Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271009 [Multi-domain]  Cd Length: 257  Bit Score: 111.13  E-value: 1.33e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 168 YGFPRRPPPRGSQATQggpAKQLLPLE-----RVYQEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDL---------- 232
Cdd:cd14107    15 FGFVKRVTHKGNGECC---AAKFIPLRsstraRAFQERDILARLSHRRLTCLLDQFE--TRKTLILILELcsseelldrl 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 233 LRKGPVMEvpcdkpfpeEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL--GDDGHVKIADFGVSNQFEGNDAQLSST 310
Cdd:cd14107    90 FLKGVVTE---------AEVKLYIQQVLEGIGYLHGMNILHLDIKPDNILMvsPTREDIKICDFGFAQEITPSEHQFSKY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 311 aGTPAFMAPEAISdsgQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKnEAVVFPEEPEV---SEDLKDLIL 387
Cdd:cd14107   161 -GSPEFVAPEIVH---QEPVSAATDIWALGVIAYLSLTCHSPFAGENDRATLLNVA-EGVVSWDTPEIthlSEDAKDFIK 235
                         250       260
                  ....*....|....*....|.
gi 1384865967 388 RMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14107   236 RVLQPDPEKRPSASECLSHEW 256
STKc_PAK_I cd06647
Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze ...
183-409 1.40e-27

Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group I PAKs, also called conventional PAKs, include PAK1, PAK2, and PAK3. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). They interact with the SH3 domain containing proteins Nck, Grb2 and PIX. Binding of group I PAKs to activated GTPases leads to conformational changes that destabilize the AID, allowing autophosphorylation and full activation of the kinase domain. Known group I PAK substrates include MLCK, Bad, Raf, MEK1, LIMK, Merlin, Vimentin, Myc, Stat5a, and Aurora A, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270814 [Multi-domain]  Cd Length: 261  Bit Score: 111.17  E-value: 1.40e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 183 QGGPAKQLlplerVYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILG 262
Cdd:cd06647    43 QQQPKKEL-----IINEILVMRENKNPNIVNYLDSY--LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATGVT 342
Cdd:cd06647   116 LEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT---RKAYGPKVDIWSLGIM 192
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 343 LYCFVYGKCPFIDDYIL-TLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06647   193 AIEMVEGEPPYLNENPLrALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHPFL 260
STKc_EIF2AK cd13996
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
125-403 1.87e-27

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: General Control Non-derepressible-2 (GCN2) which is activated during amino acid or serum starvation; protein kinase regulated by RNA (PKR) which is activated by double stranded RNA; heme-regulated inhibitor kinase (HRI) which is activated under heme-deficient conditions; and PKR-like endoplasmic reticulum kinase (PERK) which is activated when misfolded proteins accumulate in the ER. The EIF2AK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270898 [Multi-domain]  Cd Length: 273  Bit Score: 111.23  E-value: 1.87e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfpRRPPPRGSQATqggpakqllpLERVYQEIAILK 204
Cdd:cd13996     5 LNDFEEIELLGSGGFGSVYKVRNKVDGVTYAI---------------KKIRLTEKSSA----------SEKVLREVKALA 59
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKL----IEvlddpaEDNLYLVFDLLRKGPV---MEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd13996    60 KLNHPNIVRYytawVE------EPPLYIQMELCEGGTLrdwIDRRNSSSkNDRKLALELFKQILKGVSYIHSKGIVHRDL 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLL-GDDGHVKIADFG--------------VSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGV 341
Cdd:cd13996   134 KPSNIFLdNDDLQVKIGDFGlatsignqkrelnnLNNNNNGNTSNNSVGIGTPLYASPEQL--DGENYNEKA-DIYSLGI 210
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 342 TLYCFVYGKCPFIDDY-ILTLHRKIKneavvFPEE-----PEVsedlKDLILRMLDKNPETRIGVSDI 403
Cdd:cd13996   211 ILFEMLHPFKTAMERStILTDLRNGI-----LPESfkakhPKE----ADLIQSLLSKNPEERPSAEQL 269
STKc_STK10 cd06644
Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase ...
193-411 2.01e-27

Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK10/LOK is also called polo-like kinase kinase 1 in Xenopus (xPlkk1). It is highly expressed in lymphocytes and is responsible in regulating leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. It plays a role in regulating the CD28 responsive element in T cells, and may also function as a regulator of polo-like kinase 1 (Plk1), a protein which is overexpressed in multiple tumor types. The STK10 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132975 [Multi-domain]  Cd Length: 292  Bit Score: 111.66  E-value: 2.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPV--MEVPCDKPFPEEQARLYLRDIILGLEYLHCQK 270
Cdd:cd06644    53 LEDYMVEIEILATCNHPYIVKLLGAF--YWDGKLWIMIEFCPGGAVdaIMLELDRGLTEPQIQVICRQMLEALQYLHSMK 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI---SDSGQSFSGKAlDVWATGVTLYCFV 347
Cdd:cd06644   131 IIHRDLKAGNVLLTLDGDIKLADFGVSAKNVKTLQRRDSFIGTPYWMAPEVVmceTMKDTPYDYKA-DIWSLGITLIEMA 209
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 348 YGKCPFIDDYILTLHRKI-KNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTK 411
Cdd:cd06644   210 QIEPPHHELNPMRVLLKIaKSEPPTLSQPSKWSMEFRDFLKTALDKHPETRPSAAQLLEHPFVSS 274
STKc_PKB_gamma cd05593
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); ...
125-399 2.48e-27

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-gamma is predominantly expressed in neuronal tissues. Mice deficient in PKB-gamma show a reduction in brain weight due to the decreases in cell size and cell number. PKB-gamma has also been shown to be upregulated in estrogen-deficient breast cancer cells, androgen-independent prostate cancer cells, and primary ovarian tumors. It acts as a key mediator in the genesis of ovarian cancer. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270745 [Multi-domain]  Cd Length: 348  Bit Score: 112.48  E-value: 2.48e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLkqygfprrppprgsqatqggpAKQllPLERVYQEIAILK 204
Cdd:cd05593    14 MNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVII---------------------AKD--EVAHTLTESRVLK 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd05593    71 NTRHPFLTSLKYSFQ--TKDRLCFVMEYVNGGELFfHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLML 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 GDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHR 363
Cdd:cd05593   149 DKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDY---GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFE 225
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1384865967 364 KIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIG 399
Cdd:cd05593   226 LILMEDIKFPR--TLSADAKSLLSGLLIKDPNKRLG 259
STKc_PIM cd14005
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
127-409 3.20e-27

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 and three PIM2 isoforms as a result of alternative translation initiation sites, while there is only one PIM3 protein. Compound knockout mice deficient of all three PIM kinases that survive the perinatal period show a profound reduction in body size, indicating that PIMs are important for body growth. The PIM subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270907 [Multi-domain]  Cd Length: 255  Bit Score: 110.02  E-value: 3.20e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVrlaYNESEDRHyamkvlskkkllkqygfpRRP-----PPRGSQATQGG-PAKQLLPLErvyqeI 200
Cdd:cd14005     1 QYEVGDLLGKGGFGTV---YSGVRIRD------------------GLPvavkfVPKSRVTEWAMiNGPVPVPLE-----I 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 201 AILKK---LDHVNVVKLIEVLDDPaeDNLYLVFDllRKGPVM---EVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:cd14005    55 ALLLKaskPGVPGVIRLLDWYERP--DGFLLIME--RPEPCQdlfDFITERgALSENLARIIFRQVVEAVRHCHQRGVLH 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLG-DDGHVKIADFGVSNQFEgnDAQLSSTAGTPAFMAPEAISDSgqSFSGKALDVWATGVTLYCFVYGKCP 352
Cdd:cd14005   131 RDIKDENLLINlRTGEVKLIDFGCGALLK--DSVYTDFDGTRVYSPPEWIRHG--RYHGRPATVWSLGILLYDMLCGDIP 206
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 353 FI-DDYILTlhrkiknEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14005   207 FEnDEQILR-------GNVLFR--PRLSKECCDLISRCLQFDPSKRPSLEQILSHPWF 255
STKc_NDR_like_fungal cd05629
Catalytic domain of Fungal Nuclear Dbf2-Related kinase-like Serine/Threonine Kinases; STKs ...
134-410 3.84e-27

Catalytic domain of Fungal Nuclear Dbf2-Related kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This group is composed of fungal NDR-like proteins including Saccharomyces cerevisiae CBK1 (or CBK1p), Schizosaccharomyces pombe Orb6 (or Orb6p), Ustilago maydis Ukc1 (or Ukc1p), and Neurospora crassa Cot1. Like NDR kinase, group members contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. CBK1 is an essential component in the RAM (regulation of Ace2p activity and cellular morphogenesis) network. CBK1 and Orb6 play similar roles in coordinating cell morphology with cell cycle progression. Ukc1 is involved in morphogenesis, pathogenicity, and pigment formation. Cot1 plays a role in polar tip extension.The fungal NDR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270778 [Multi-domain]  Cd Length: 377  Bit Score: 112.64  E-value: 3.84e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLLPLE--------RVYQEIAILKK 205
Cdd:cd05629     9 IGKGAFGEVRLVQKKDTGKIYAM-------------------------------KTLLKSEmfkkdqlaHVKAERDVLAE 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCD-KPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd05629    58 SDSPWVVSLYYSFQDAQY--LYLIMEFLPGGDLMTMLIKyDTFSEDVTRFYMAECVLAIEAVHKLGFIHRDIKPDNILID 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQF-------------EGNDAQ-----------------LS-----------------STAGTPAFM 317
Cdd:cd05629   136 RGGHIKLSDFGLSTGFhkqhdsayyqkllQGKSNKnridnrnsvavdsinltMSskdqiatwkknrrlmaySTVGTPDYI 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 318 APEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKN--EAVVFPEEPEVSEDLKDLILRMLdKNPE 395
Cdd:cd05629   216 APEIFLQQGYGQE---CDWWSLGAIMFECLIGWPPFCSENSHETYRKIINwrETLYFPDDIHLSVEAEDLIRRLI-TNAE 291
                         330
                  ....*....|....*...
gi 1384865967 396 TRIG---VSDIKLHPWVT 410
Cdd:cd05629   292 NRLGrggAHEIKSHPFFR 309
STKc_PLK3 cd14189
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the ...
194-406 9.56e-27

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK3, also called Prk or Fnk (FGF-inducible kinase), regulates angiogenesis and responses to DNA damage. Activated PLK3 mediates Chk2 phosphorylation by ATM and the resulting checkpoint activation. PLK3 phosphorylates DNA polymerase delta and may be involved in DNA repair. It also inhibits Cdc25c, thereby regulating the onset of mitosis. The PLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271091 [Multi-domain]  Cd Length: 255  Bit Score: 108.86  E-value: 9.56e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEV-PCDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd14189    46 EKIVNEIELHRDLHHKHVVKFSHHFED--AENIYIFLELCSRKSLAHIwKARHTLLEPEVRYYLKQIISGLKYLHLKGIL 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCP 352
Cdd:cd14189   124 HRDLKLGNFFINENMELKVGDFGLAARLEPPEQRKKTICGTPNYLAPEVLLRQGH---GPESDVWSLGCVMYTLLCGNPP 200
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 353 FIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLH 406
Cdd:cd14189   201 FETLDLKETYRCIKQVKYTLPA--SLSLPARHLLAGILKRNPGDRLTLDQILEH 252
STKc_GRK4 cd05631
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs ...
199-407 9.82e-27

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK4 has a limited tissue distribution. It is mainly found in the testis, but is also present in the cerebellum and kidney. It is expressed as multiple splice variants with different domain architectures and is post-translationally palmitoylated and localized in the membrane. GRK4 polymorphisms are associated with hypertension and salt sensitivity, as they cause hyperphosphorylation, desensitization, and internalization of the dopamine 1 (D1) receptor while increasing the expression of the angiotensin II type 1 receptor. GRK4 plays a crucial role in the D1 receptor regulation of sodium excretion and blood pressure. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173720 [Multi-domain]  Cd Length: 285  Bit Score: 109.31  E-value: 9.82e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPV------MEVPcdkPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd05631    50 EKRILEKVNSRFVVSLAYAYE--TKDALCLVLTIMNGGDLkfhiynMGNP---GFDEQRAIFYAAELCCGLEDLQRERIV 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQF-EGNdaQLSSTAGTPAFMAPEAISDSGQSFSGkalDVWATGVTLYCFVYGKC 351
Cdd:cd05631   125 YRDLKPENILLDDRGHIRISDLGLAVQIpEGE--TVRGRVGTVGYMAPEVINNEKYTFSP---DWWGLGCLIYEMIQGQS 199
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 352 PF-----------IDdyiltlhRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRI-----GVSDIKLHP 407
Cdd:cd05631   200 PFrkrkervkreeVD-------RRVKEDQEEYSE--KFSEDAKSICRMLLTKNPKERLgcrgnGAAGVKQHP 262
PK_Unc-89_rpt1 cd14109
Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein ...
181-409 9.91e-27

Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The pseudokinase domain may function as a regulatory domain or a protein interaction domain. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271011 [Multi-domain]  Cd Length: 255  Bit Score: 108.75  E-value: 9.91e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 181 ATQGGP------------AKQLLPL-ERVYQEIAILKKLDHVNVVKLIEVLDDPAE-----DNLYLVFDLLRkgpVMEVP 242
Cdd:cd14109    15 AAQGAPfhvterstgrnfLAQLRYGdPFLMREVDIHNSLDHPNIVQMHDAYDDEKLavtviDNLASTIELVR---DNLLP 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 243 CDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDgHVKIADFGVSNQFegNDAQLSST-AGTPAFMAPEA 321
Cdd:cd14109    92 GKDYYTERQVAVFVRQLLLALKHMHDLGIAHLDLRPEDILLQDD-KLKLADFGQSRRL--LRGKLTTLiYGSPEFVSPEI 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 322 ISDSGQSFsgkALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIG 399
Cdd:cd14109   169 VNSYPVTL---ATDMWSVGVLTYVLLGGISPFLGDNDRETLTNVRSGKWSFDSSPlgNISDDARDFIKKLLVYIPESRLT 245
                         250
                  ....*....|
gi 1384865967 400 VSDIKLHPWV 409
Cdd:cd14109   246 VDEALNHPWF 255
STKc_MSK1_C cd14179
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
198-409 1.15e-26

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271081 [Multi-domain]  Cd Length: 310  Bit Score: 109.74  E-value: 1.15e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLD-HVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd14179    50 REIAALKLCEgHPNIVKLHEVYHD--QLHTFLVMELLKGGELLErIKKKQHFSETEASHIMRKLVSAVSHMHDVGVVHRD 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLLGDDG---HVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCP 352
Cdd:cd14179   128 LKPENLLFTDESdnsEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNYNGYD---ESCDLWSLGVILYTMLSGQVP 204
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 353 F-IDDYILT------LHRKIKNEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14179   205 FqCHDKSLTctsaeeIMKKIKQGDFSFEGEAwkNVSQEAKDLIQGLLTVDPNKRIKMSGLRYNEWL 270
STKc_MSK2_N cd05614
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
184-408 1.29e-26

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270765 [Multi-domain]  Cd Length: 332  Bit Score: 110.01  E-value: 1.29e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 184 GGPAKQLLPLERVYQEIAILKK-------------LDHVNVVKLIEVLDDP--AEDNLYLVFDLLRKGPVMEVPCDKP-F 247
Cdd:cd05614    23 SGHDANKLYAMKVLRKAALVQKaktvehtrternvLEHVRQSPFLVTLHYAfqTDAKLHLILDYVSGGELFTHLYQRDhF 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 248 PEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLS-STAGTPAFMAPEAIsdSG 326
Cdd:cd05614   103 SEDEVRFYSGEIILALEHLHKLGIVYRDIKLENILLDSEGHVVLTDFGLSKEFLTEEKERTySFCGTIEYMAPEII--RG 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 327 QSFSGKALDVWATGVTLYCFVYGKCPFiddyilTLHRKIKNEAVV----------FPeePEVSEDLKDLILRMLDKNPET 396
Cdd:cd05614   181 KSGHGKAVDWWSLGILMFELLTGASPF------TLEGEKNTQSEVsrrilkcdppFP--SFIGPVARDLLQKLLCKDPKK 252
                         250
                  ....*....|....*..
gi 1384865967 397 RI-----GVSDIKLHPW 408
Cdd:cd05614   253 RLgagpqGAQEIKEHPF 269
STKc_Sck1_like cd05586
Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine ...
225-408 1.47e-26

Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Sck1 and similar fungal proteins. Sck1 plays a role in trehalase activation triggered by glucose and a nitrogen source. Trehalase catalyzes the cleavage of the disaccharide trehalose to glucose. Trehalose, as a carbohydrate reserve and stress metabolite, plays an important role in the response of yeast to environmental changes. The Sck1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270738 [Multi-domain]  Cd Length: 330  Bit Score: 109.97  E-value: 1.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 225 NLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGN 303
Cdd:cd05586    70 DLYLVTDYMSGGELFwHLQKEGRFSEDRAKFYIAELVLALEHLHKNDIVYRDLKPENILLDANGHIALCDFGLSKADLTD 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 304 DAQLSSTAGTPAFMAPEAISDsgQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEpEVSEDLK 383
Cdd:cd05586   150 NKTTNTFCGTTEYLAPEVLLD--EKGYTKMVDFWSLGVLVFEMCCGWSPFYAEDTQQMYRNIAFGKVRFPKD-VLSDEGR 226
                         170       180
                  ....*....|....*....|....*....
gi 1384865967 384 DLILRMLDKNPETRIGVSD----IKLHPW 408
Cdd:cd05586   227 SFVKGLLNRNPKHRLGAHDdaveLKEHPF 255
STKc_SGK3 cd05604
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
134-408 1.49e-26

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK3 (also called cytokine-independent survival kinase or CISK) is expressed in most tissues and is most abundant in the embryo and adult heart and spleen. It was originally discovered in a screen for antiapoptotic genes. It phosphorylates and inhibits the proapoptotic proteins, Bad and FKHRL1. SGK3 also regulates many transporters, ion channels, and receptors. It plays a critical role in hair follicle morphogenesis and hair cycling. The SGK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270755 [Multi-domain]  Cd Length: 326  Bit Score: 110.05  E-value: 1.49e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKqygfprrpppRGSQatqggpaKQLLPLERVyqeiaILKKLDHVNVVK 213
Cdd:cd05604     4 IGKGSFGKVLLAKRKRDGKYYAVKVLQKKVILN----------RKEQ-------KHIMAERNV-----LLKNVKHPFLVG 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDdpAEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd05604    62 LHYSFQ--TTDKLYFVLDFVNGGELFfHLQRERSFPEPRARFYAAEIASALGYLHSINIVYRDLKPENILLDSQGHIVLT 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDsgQSFSgKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVF 372
Cdd:cd05604   140 DFGLCKEGISNSDTTTTFCGTPEYLAPEVIRK--QPYD-NTVDWWCLGSVLYEMLYGLPPFYCRDTAEMYENILHKPLVL 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1384865967 373 peEPEVSEDLKDLILRMLDKNPETRIGVS----DIKLHPW 408
Cdd:cd05604   217 --RPGISLTAWSILEELLEKDRQLRLGAKedflEIKNHPF 254
STKc_YSK4 cd06631
Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs ...
194-409 1.51e-26

Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. YSK4 is a putative MAPKKK, whose mammalian gene has been isolated. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The YSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270801 [Multi-domain]  Cd Length: 266  Bit Score: 108.29  E-value: 1.51e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVlddPAEDNLYLVFdllrkgpvME-VPCDK---------PFPEEQARLYLRDIILGL 263
Cdd:cd06631    48 EKLQEEVDLLKTLKHVNIVGYLGT---CLEDNVVSIF--------MEfVPGGSiasilarfgALEEPVFCRYTKQILEGV 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 264 EYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS-----NQFEGNDAQ-LSSTAGTPAFMAPEAISDSGQsfsGKALDVW 337
Cdd:cd06631   117 AYLHNNNVIHRDIKGNNIMLMPNGVIKLIDFGCAkrlciNLSSGSQSQlLKSMRGTPYWMAPEVINETGH---GRKSDIW 193
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 338 ATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPE-VSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06631   194 SIGCTVFEMATGKPPWADMNPMAAIFAIGSGRKPVPRLPDkFSPEARDFVHACLTRDQDERPSAEQLLKHPFI 266
STKc_MEKK3_like_u1 cd06653
Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP) ...
128-409 1.81e-26

Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized proteins with similarity to MEKK3, MEKK2, and related proteins; they contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKKs), proteins that phosphorylate and activate MAPK kinases (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MEKK2 and MEKK3 activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270819 [Multi-domain]  Cd Length: 264  Bit Score: 108.19  E-value: 1.81e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPpprGSQATqggpAKQLLPLErvyQEIAILKKLD 207
Cdd:cd06653     4 WRLGKLLGRGAFGEVYLCYDADTGRELAVKQ-----------VPFDP---DSQET----SKEVNALE---CEIQLLKNLR 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd06653    63 HDRIVQYYGCLRDPEEKKLSIFVEYMPGGSVKdQLKAYGALTENVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSA 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 GHVKIADFGVSNQFEG---NDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHR 363
Cdd:cd06653   143 GNVKLGDFGASKRIQTicmSGTGIKSVTGTPYWMSPEVISGEGY---GRKADVWSVACTVVEMLTEKPPWAEYEAMAAIF 219
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1384865967 364 KIKNEavvfPEEPEVSEDLKDL---ILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06653   220 KIATQ----PTKPQLPDGVSDAcrdFLRQIFVEEKRRPTAEFLLRHPFV 264
STKc_NDR1 cd05628
Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1; STKs catalyze ...
134-404 2.19e-26

Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR1 (also called STK38) plays a role in proper centrosome duplication. It is highly expressed in thymus, muscle, lung and spleen. It is not an essential protein because mice deficient of NDR1 remain viable and fertile. However, these mice develop T-cell lymphomas and appear to be hypersenstive to carcinogenic treatment. NDR1 appears to also act as a tumor suppressor. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270777 [Multi-domain]  Cd Length: 376  Bit Score: 110.51  E-value: 2.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLkqygfprrppprgsQATQGGpakqllpleRVYQEIAILKKLDHVNVVK 213
Cdd:cd05628     9 IGRGAFGEVRLVQKKDTGHVYAMKILRKADML--------------EKEQVG---------HIRAERDILVEADSLWVVK 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDPAedNLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd05628    66 MFYSFQDKL--NLYLIMEFLPGGDMMTLLMKKdTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLS 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGV----------------------------------SNQFEGNDAQLS-STAGTPAFMAPEAISDSGQSfsgKALDVW 337
Cdd:cd05628   144 DFGLctglkkahrtefyrnlnhslpsdftfqnmnskrkAETWKRNRRQLAfSTVGTPDYIAPEVFMQTGYN---KLCDWW 220
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 338 ATGVTLYCFVYGKCPFIDDYILTLHRKIKN--EAVVFPEEPEVSEDLKDLILRMLDKNpETRIGVSDIK 404
Cdd:cd05628   221 SLGVIMYEMLIGYPPFCSETPQETYKKVMNwkETLIFPPEVPISEKAKDLILRFCCEW-EHRIGAPGVE 288
STKc_MEKK2 cd06652
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
128-390 3.55e-26

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK2 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK2 also activates ERK1/2, c-Jun N-terminal kinase (JNK) and p38 through their respective MAPKKs MEK1/2, JNK-activating kinase 2 (JNKK2), and MKK3/6. MEKK2 plays roles in T cell receptor signaling, immune synapse formation, cytokine gene expression, as well as in EGF and FGF receptor signaling. The MEKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270818 [Multi-domain]  Cd Length: 264  Bit Score: 107.44  E-value: 3.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKvlskkkllkQYGFPRRPPPrgsqatqggPAKQLLPLErvyQEIAILKKLD 207
Cdd:cd06652     4 WRLGKLLGQGAFGRVYLCYDADTGRELAVK---------QVQFDPESPE---------TSKEVNALE---CEIQLLKNLL 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd06652    63 HERIVQYYGCLRDPQERTLSIFMEYMPGGSIKdQLKSYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSV 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 GHVKIADFGVSNQFEG---NDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHR 363
Cdd:cd06652   143 GNVKLGDFGASKRLQTiclSGTGMKSVTGTPYWMSPEVISGEGY---GRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIF 219
                         250       260
                  ....*....|....*....|....*..
gi 1384865967 364 KIKNEAVVFPEEPEVSEDLKDLILRML 390
Cdd:cd06652   220 KIATQPTNPQLPAHVSDHCRDFLKRIF 246
STKc_MLCK2 cd14190
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze ...
194-409 4.17e-26

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK2 (or MYLK2) phosphorylates myosin regulatory light chain and controls the contraction of skeletal muscles. MLCK2 contains a single kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site. The MLCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271092 [Multi-domain]  Cd Length: 261  Bit Score: 106.93  E-value: 4.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVME--VPCDKPFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd14190    46 EMVLLEIQVMNQLNHRNLIQLYEAIETPNE--IVLFMEYVEGGELFEriVDEDYHLTEVDAMVFVRQICEGIQFMHQMRV 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLL-GDDGH-VKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYG 349
Cdd:cd14190   124 LHLDLKPENILCvNRTGHqVKIIDFGLARRYNPRE-KLKVNFGTPEFLSPEVVNYDQVSFP---TDMWSMGVITYMLLSG 199
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 350 KCPFI-DDYILTLHRKIKNEAvVFPEEP--EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14190   200 LSPFLgDDDTETLNNVLMGNW-YFDEETfeHVSDEAKDFVSNLIIKERSARMSATQCLKHPWL 261
STKc_MST4 cd06640
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs ...
193-415 5.85e-26

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST4 is sometimes referred to as MASK (MST3 and SOK1-related kinase). It plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. It influences cell growth and transformation by modulating the extracellular signal-regulated kinase (ERK) pathway. MST4 may also play a role in tumor formation and progression. It localizes in the Golgi apparatus by interacting with the Golgi matrix protein GM130 and may play a role in cell migration. The MST4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132971 [Multi-domain]  Cd Length: 277  Bit Score: 107.06  E-value: 5.85e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd06640    46 IEDIQQEITVLSQCDSPYVTKYYGSYLKGTK--LWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKI 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSgqSFSGKAlDVWATGVTLYCFVYGKCP 352
Cdd:cd06640   124 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS--AYDSKA-DIWSLGITAIELAKGEPP 200
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 353 FIDDYILTLHRKI-KNEAVVFpeEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEE 415
Cdd:cd06640   201 NSDMHPMRVLFLIpKNNPPTL--VGDFSKPFKEFIDACLNKDPSFRPTAKELLKHKFIVKNAKK 262
STKc_MAPKAPK cd14089
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated ...
207-408 7.31e-26

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPK-activated protein kinases MK2, MK3, MK5 (also called PRAK for p38-regulated/activated protein kinase), and related proteins. These proteins contain a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. In addition, MK2 and MK3 contain an N-terminal proline-rich region that can bind to SH3 domains. MK2 and MK3 are bonafide substrates for the MAPK p38, while MK5 plays a functional role in the p38 MAPK pathway although their direct interaction has been difficult to detect. MK2 and MK3 are closely related and show, thus far, indistinguishable substrate specificity, while MK5 shows a distinct spectrum of substrates. MK2 and MK3 are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270991 [Multi-domain]  Cd Length: 263  Bit Score: 106.22  E-value: 7.31e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAEDNLYLVFdllrkgpVMEvpC--------------DKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd14089    52 GCPHIVRIIDVYENTYQGRKCLLV-------VME--CmeggelfsriqeraDSAFTEREAAEIMRQIGSAVAHLHSMNIA 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLL---GDDGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAIsdsGQSFSGKALDVWATGVTLYCFVYG 349
Cdd:cd14089   123 HRDLKPENLLYsskGPNAILKLTDFGFAKETTTKKS-LQTPCYTPYYVAPEVL---GPEKYDKSCDMWSLGVIMYILLCG 198
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 350 KCPFIDDYILTL----HRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14089   199 YPPFYSNHGLAIspgmKKRIRNGQYEFPNPewSNVSEEAKDLIRGLLKTDPSERLTIEEVMNHPW 263
STKc_ULK2 cd14201
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the ...
198-409 7.37e-26

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK2 is ubiquitously expressed and is essential in autophagy induction. It displays partially redundant functions with ULK1 and is able to compensate for the loss of ULK1 in non-selective autophagy. It also displays neuron-specific functions and is important in axon development. The ULK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271103 [Multi-domain]  Cd Length: 271  Bit Score: 106.63  E-value: 7.37e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd14201    54 KEIKILKELQHENIVALYDVQEMP--NSVFLVMEYCNGGDLADyLQAKGTLSEDTIRVFLQQIAAAMRILHSKGIIHRDL 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDG---------HVKIADFGVSNQFEGNdAQLSSTAGTPAFMAPEAISDsgQSFSGKAlDVWATGVTLYCFV 347
Cdd:cd14201   132 KPQNILLSYASrkkssvsgiRIKIADFGFARYLQSN-MMAATLCGSPMYMAPEVIMS--QHYDAKA-DLWSIGTVIYQCL 207
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 348 YGKCPFIDDY---ILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14201   208 VGKPPFQANSpqdLRMFYEKNKNLQPSIPR--ETSPYLADLLLGLLQRNQKDRMDFEAFFSHPFL 270
STKc_Nek5 cd08225
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
127-409 7.78e-26

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The specific function of Nek5 is unknown. Nek5 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173765 [Multi-domain]  Cd Length: 257  Bit Score: 106.20  E-value: 7.78e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKkllkqygfprRPPPRGSQATQggpakqllplervyQEIAILKKL 206
Cdd:cd08225     1 RYEIIKKIGEGSFGKIYLAKAKSDSEHCVIKEIDLT----------KMPVKEKEASK--------------KEVILLAKM 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKP---FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd08225    57 KHPNIVTFFASFQE--NGRLFIVMEYCDGGDLMKRINRQRgvlFSEDQILSWFVQISLGLKHIHDRKILHRDIKSQNIFL 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 GDDGHV-KIADFGVSNQFEgNDAQLSST-AGTPAFMAPEAISDsgQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTL 361
Cdd:cd08225   135 SKNGMVaKLGDFGIARQLN-DSMELAYTcVGTPYYLSPEICQN--RPYNNKT-DIWSLGCVLYELCTLKHPFEGNNLHQL 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 362 HRKIkNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd08225   211 VLKI-CQGYFAPISPNFSRDLRSLISQLFKVSPRDRPSITSILKRPFL 257
PKc_MAPKK cd06605
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase ...
245-412 8.01e-26

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MAPKKs are dual-specificity PKs that phosphorylate their downstream targets, MAPKs, at specific threonine and tyrosine residues. The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising the MAPK, which is phosphorylated and activated by a MAPK kinase (MAPKK or MKK or MAP2K), which itself is phosphorylated and activated by a MAPKK kinase (MAPKKK or MKKK or MAP3K). There are three MAPK subfamilies: extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. In mammalian cells, there are seven MAPKKs (named MKK1-7) and 20 MAPKKKs. Each MAPK subfamily can be activated by at least two cognate MAPKKs and by multiple MAPKKKs. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270782 [Multi-domain]  Cd Length: 265  Bit Score: 106.28  E-value: 8.01e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 245 KPFPEEQARLYLRDIILGLEYLHCQ-KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAIs 323
Cdd:cd06605    94 GRIPERILGKIAVAVVKGLIYLHEKhKIIHRDVKPSNILVNSRGQVKLCDFGVSGQLVDSLAK--TFVGTRSYMAPERI- 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 324 dSGQSFSGKAlDVWATGVTLYCFVYGKCPF----IDDY--ILTLHRKIKNEAVvfPEEP--EVSEDLKDLILRMLDKNPE 395
Cdd:cd06605   171 -SGGKYTVKS-DIWSLGLSLVELATGRFPYpppnAKPSmmIFELLSYIVDEPP--PLLPsgKFSPDFQDFVSQCLQKDPT 246
                         170
                  ....*....|....*..
gi 1384865967 396 TRIGVSDIKLHPWVTKH 412
Cdd:cd06605   247 ERPSYKELMEHPFIKRY 263
STKc_PAK2 cd06655
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the ...
183-409 8.82e-26

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1. It belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132986 [Multi-domain]  Cd Length: 296  Bit Score: 107.12  E-value: 8.82e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 183 QGGPAKQLlplerVYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILG 262
Cdd:cd06655    55 QKQPKKEL-----IINEILVMKELKNPNIVNFLDSF--LVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQA 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVT 342
Cdd:cd06655   128 LEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY---GPKVDIWSLGIM 204
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 343 LYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPE-VSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06655   205 AIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEkLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL 272
STKc_Byr2_like cd06628
Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein ...
134-409 9.73e-26

Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Schizosaccharomyces pombe Byr2, Saccharomyces cerevisiae and Cryptococcus neoformans Ste11, and related proteins. They contain an N-terminal SAM (sterile alpha-motif) domain, which mediates protein-protein interaction, and a C-terminal catalytic domain. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Byr2 is regulated by Ras1. It responds to pheromone signaling and controls mating through the MAPK pathway. Budding yeast Ste11 functions in MAPK cascades that regulate mating, high osmolarity glycerol, and filamentous growth responses. The Byr2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270798 [Multi-domain]  Cd Length: 267  Bit Score: 106.08  E-value: 9.73e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrppPRGSQATQGGPAKQLLPLERvyqEIAILKKLDHVNVVK 213
Cdd:cd06628     8 IGSGSFGSVYLGMNASSGELMAVKQVEL--------------PSVSAENKDRKKSMLDALQR---EIALLRELQHENIVQ 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDpaEDNLYLVFDLLRKGPVMEVPCD-KPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd06628    71 YLGSSSD--ANHLNIFLEYVPGGSVATLLNNyGAFEESLVRNFVRQILKGLNYLHNRGIIHRDIKGANILVDNKGGIKIS 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGVSNQFE------GNDAQLSSTAGTPAFMAPEAISDSgqSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLHRKIK 366
Cdd:cd06628   149 DFGISKKLEanslstKNNGARPSLQGSVFWMAPEVVKQT--SYTRKA-DIWSLGCLVVEMLTGTHPFPDCTQMQAIFKIG 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 367 NEAVvfPEEPE-VSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06628   226 ENAS--PTIPSnISSEARDFLEKTFEIDHNKRPTADELLKHPFL 267
STKc_Cdc7 cd14019
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze ...
126-407 1.04e-25

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Cdc7 kinase (or Hsk1 in fission yeast) is a critical regulator in the initiation of DNA replication. It forms a complex with a Dbf4-related regulatory subunit, a cyclin-like molecule that activates the kinase in late G1 phase, and is also referred to as Dbf4-dependent kinase (DDK). Its main targets are mini-chromosome maintenance (MCM) proteins. Cdc7 kinase may also have additional roles in meiosis, checkpoint responses, the maintenance and repair of chromosome structures, and cancer progression. The Cdc7 kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270921 [Multi-domain]  Cd Length: 252  Bit Score: 105.77  E-value: 1.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAynesEDRHYAmkvlskkkllkqyGFPRRPPPRGSqatqggpAKQLLPL---ERVYQEIAI 202
Cdd:cd14019     1 NKYRIIEKIGEGTFSSVYKA----EDKLHD-------------LYDRNKGRLVA-------LKHIYPTsspSRILNELEC 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 203 LKKLD-HVNVVKLIEVLDDpaEDNLYLVF---------DLLRKGPVMEVpcdkpfpeeqaRLYLRDIILGLEYLHCQKIV 272
Cdd:cd14019    57 LERLGgSNNVSGLITAFRN--EDQVVAVLpyiehddfrDFYRKMSLTDI-----------RIYLRNLFKALKHVHSFGII 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLG-DDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSG-QSfsgKALDVWATGVTLYCFVYGK 350
Cdd:cd14019   124 HRDVKPGNFLYNrETGKGVLVDFGLAQREEDRPEQRAPRAGTRGFRAPEVLFKCPhQT---TAIDIWSAGVILLSILSGR 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 351 CPFI---DDYIltlhrKIKNEAVVFPeepevSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd14019   201 FPFFfssDDID-----ALAEIATIFG-----SDEAYDLLDKLLELDPSKRITAEEALKHP 250
PKc_Wee1_like cd13997
Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the ...
194-407 1.05e-25

Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity kinase Myt1, the protein tyrosine kinase Wee1, and similar proteins. These proteins are cell cycle checkpoint kinases that are involved in the regulation of cyclin-dependent kinase CDK1, the master engine for mitosis. CDK1 is kept inactivated through phosphorylation of N-terminal thr (T14 by Myt1) and tyr (Y15 by Myt1 and Wee1) residues. Mitosis progression is ensured through activation of CDK1 by dephoshorylation and inactivation of Myt1/Wee1. The Wee1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270899 [Multi-domain]  Cd Length: 252  Bit Score: 105.54  E-value: 1.05e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKL-DHVNVVkliEVLDDPAEDN-LYLVFDLLRKGPVMEVPCDKP----FPEEQARLYLRDIILGLEYLH 267
Cdd:cd13997    44 ARALREVEAHAALgQHPNIV---RYYSSWEEGGhLYIQMELCENGSLQDALEELSpiskLSEAEVWDLLLQVALGLAFIH 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 268 CQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE-GNDAQlsstAGTPAFMAPEAISDSGQsfSGKALDVWATGVTLYCF 346
Cdd:cd13997   121 SKGIVHLDIKPDNIFISNKGTCKIGDFGLATRLEtSGDVE----EGDSRYLAPELLNENYT--HLPKADIFSLGVTVYEA 194
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 347 VYGKcPFIDDYilTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd13997   195 ATGE-PLPRNG--QQWQQLRQGKLPLPPGLVLSQELTRLLKVMLDPDPTRRPTADQLLAHD 252
STKc_CDK7 cd07841
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs ...
199-422 1.06e-25

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain, it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA, as present in the pre-initiation complex. Following phosphorylation, the CTD dissociates from the DNA which allows transcription initiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270833 [Multi-domain]  Cd Length: 298  Bit Score: 106.89  E-value: 1.06e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLrKGPVMEVPCDK--PFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd07841    52 EIKLLQELKHPNIIGLLDVF--GHKSNINLVFEFM-ETDLEKVIKDKsiVLTPADIKSYMLMTLRGLEYLHSNWILHRDL 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKcPF--- 353
Cdd:cd07841   129 KPNNLLIASDGVLKLADFGLARSFGSPNRKMTHQVVTRWYRAPELL--FGARHYGVGVDMWSVGCIFAELLLRV-PFlpg 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 354 ---ID------------------------DYILTLHRKIKNEAVVFpeePEVSEDLKDLILRMLDKNPETRIGVSDIKLH 406
Cdd:cd07841   206 dsdIDqlgkifealgtpteenwpgvtslpDYVEFKPFPPTPLKQIF---PAASDDALDLLQRLLTLNPNKRITARQALEH 282
                         250
                  ....*....|....*.
gi 1384865967 407 PWVTkhgEEPLPSEEE 422
Cdd:cd07841   283 PYFS---NDPAPTPPS 295
STKc_Nek6 cd08228
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
198-408 1.12e-25

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 is required for the transition from metaphase to anaphase. It also plays important roles in mitotic spindle formation and cytokinesis. Activated by Nek9 during mitosis, Nek6 phosphorylates Eg5, a kinesin that is important for spindle bipolarity. Nek6 localizes to spindle microtubules during metaphase and anaphase, and to the midbody during cytokinesis. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270865 [Multi-domain]  Cd Length: 268  Bit Score: 105.88  E-value: 1.12e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLievLDDPAEDN-LYLVFDLLRKGPVMEV-----PCDKPFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd08228    51 KEIDLLKQLNHPNVIKY---LDSFIEDNeLNIVLELADAGDLSQMikyfkKQKRLIPERTVWKYFVQLCSAVEHMHSRRV 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGkalDVWATGVTLYCFVYGKC 351
Cdd:cd08228   128 MHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKS---DIWSLGCLLYEMAALQS 204
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 352 PFIDDY--ILTLHRKIknEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIGVSDI-----KLHPW 408
Cdd:cd08228   205 PFYGDKmnLFSLCQKI--EQCDYPPLPteHYSEKLRELVSMCIYPDPDQRPDIGYVhqiakQMHVW 268
STKc_PKB_alpha cd05594
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); ...
244-399 1.19e-25

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-alpha is predominantly expressed in endothelial cells. It is critical for the regulation of angiogenesis and the maintenance of vascular integrity. It also plays a role in adipocyte differentiation. Mice deficient in PKB-alpha exhibit perinatal morbidity, growth retardation, reduction in body weight accompanied by reduced sizes of multiple organs, and enhanced apoptosis in some cell types. PKB-alpha activity has been reported to be frequently elevated in breast and prostate cancers. In some cancer cells, PKB-alpha may act as a suppressor of metastasis. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270746 [Multi-domain]  Cd Length: 356  Bit Score: 107.81  E-value: 1.19e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 244 DKPFPEEQARLYLRDIILGLEYLHCQK-IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 322
Cdd:cd05594   119 ERVFSEDRARFYGAEIVSALDYLHSEKnVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVL 198
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 323 SDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIG 399
Cdd:cd05594   199 EDNDY---GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR--TLSPEAKSLLSGLLKKDPKQRLG 270
STKc_Trio_C cd14113
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
188-409 1.20e-25

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Triple functional domain protein (Trio), also called PTPRF-interacting protein, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. Trio plays important roles in neuronal cell migration and axon guidance. It was originally identified as an interacting partner of the of the receptor-like tyrosine phosphatase (RPTP) LAR (leukocyte-antigen-related protein), a family of receptors that function in the signaling to the actin cytoskeleton during development. Trio functions as a GEF for Rac1, RhoG, and RhoA, and is involved in the regulation of lamellipodia formation, mediating Rac1-dependent cell spreading and migration. The Trio subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271015 [Multi-domain]  Cd Length: 263  Bit Score: 105.83  E-value: 1.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 188 KQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAedNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYL 266
Cdd:cd14113    42 KKLMKRDQVTHELGVLQSLQHPQLVGLLDTFETPT--SYILVLEMADQGRLLDyVVRWGNLTEEKIRFYLREILEALQYL 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 267 HCQKIVHRDIKPSNLLLGDDGH---VKIADFGvsnqfegnDA-QLSST------AGTPAFMAPEAISDSGQSFSGkalDV 336
Cdd:cd14113   120 HNCRIAHLDLKPENILVDQSLSkptIKLADFG--------DAvQLNTTyyihqlLGSPEFAAPEIILGNPVSLTS---DL 188
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 337 WATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14113   189 WSIGVLTYVLLSGVSPFLDESVEETCLNICRLDFSFPDDyfKGVSQKAKDFVCFLLQMDPAKRPSAALCLQEQWL 263
STKc_MST3 cd06641
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs ...
193-415 1.52e-25

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. It may also regulate paxillin and consequently, cell migration. MST3 is present in human placenta, where it plays an essential role in the oxidative stress-induced apoptosis of trophoblasts in normal spontaneous delivery. Dysregulation of trophoblast apoptosis may result in pregnancy complications such as preeclampsia and intrauterine growth retardation. The MST3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270809 [Multi-domain]  Cd Length: 277  Bit Score: 105.92  E-value: 1.52e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLI-EVLDDpaeDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd06641    46 IEDIQQEITVLSQCDSPYVTKYYgSYLKD---TKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKK 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSgqSFSGKAlDVWATGVTLYCFVYGKC 351
Cdd:cd06641   123 IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRN*FVGTPFWMAPEVIKQS--AYDSKA-DIWSLGITAIELARGEP 199
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 352 PFIDDYILTLHRKI-KNEAVVFpeEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEE 415
Cdd:cd06641   200 PHSELHPMKVLFLIpKNNPPTL--EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKK 262
STKc_DRAK2 cd14198
The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
126-409 1.98e-25

The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2 (also called STK17B). Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. DRAK2 has been implicated in inducing or enhancing apoptosis in beta cells, fibroblasts, and lymphoid cells, where it is highly expressed. It is involved in regulating many immune processes including the germinal center (GC) reaction, responses to thymus-dependent antigens, activated T cell survival, memory T cell responses. It may be involved in the development of autoimmunity. The DRAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271100 [Multi-domain]  Cd Length: 270  Bit Score: 105.39  E-value: 1.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQS-EIGKGAYGVVRLAYNESEDRHYAmkvlskkkllKQYGFPRRpppRGSQATQggpakqllpleRVYQEIAILK 204
Cdd:cd14198     7 NFYILTSkELGRGKFAVVRQCISKSTGQEYA----------AKFLKKRR---RGQDCRA-----------EILHEIAVLE 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KL-DHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVME--VP-CDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSN 280
Cdd:cd14198    63 LAkSNPRVVNLHEVYETTSE--IILILEYAAGGEIFNlcVPdLAEMVSENDIIRLIRQILEGVYYLHQNNIVHLDLKPQN 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 281 LLLGDD---GHVKIADFGVSNQFeGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPFIDDY 357
Cdd:cd14198   141 ILLSSIyplGDIKIVDFGMSRKI-GHACELREIMGTPEYLAPEILNYDPIT---TATDMWNIGVIAYMLLTHESPFVGED 216
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 358 ILTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14198   217 NQETFLNISQVNVDYSEEtfSSVSQLATDFIQKLLVKNPEKRPTAEICLSHSWL 270
STKc_MLCK4 cd14193
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze ...
194-409 2.05e-25

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. MLCK4 (or MYLK4 or SgK085) contains a single kinase domain near the C-terminus. The MLCK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271095 [Multi-domain]  Cd Length: 261  Bit Score: 105.00  E-value: 2.05e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVPCDKPF--PEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd14193    46 EEVKNEIEVMNQLNHANLIQLYDAFE--SRNDIVLVMEYVDGGELFDRIIDENYnlTELDTILFIKQICEGIQYMHQMYI 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLL--GDDGHVKIADFGVSNQFEGNDaQLSSTAGTPAFMAPEAISDSGQSFsgkALDVWATGVTLYCFVYG 349
Cdd:cd14193   124 LHLDLKPENILCvsREANQVKIIDFGLARRYKPRE-KLRVNFGTPEFLAPEVVNYEFVSF---PTDMWSLGVIAYMLLSG 199
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 350 KCPFI-DDYILTLHRKIKNEAVVFPEE-PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14193   200 LSPFLgEDDNETLNNILACQWDFEDEEfADISEEAKDFISKLLIKEKSWRMSASEALKHPWL 261
STKc_nPKC_eta cd05590
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the ...
134-412 2.25e-25

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-eta is predominantly expressed in squamous epithelia, where it plays a crucial role in the signaling of cell-type specific differentiation. It is also expressed in pro-B cells and early-stage thymocytes, and acts as a key regulator in early B-cell development. PKC-eta increases glioblastoma multiforme (GBM) proliferation and resistance to radiation, and is being developed as a therapeutic target for the management of GBM. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-eta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270742 [Multi-domain]  Cd Length: 323  Bit Score: 106.53  E-value: 2.25e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQygfprrpppRGSQATQggPAKQLLPLERvyqeiailkklDHVNVVK 213
Cdd:cd05590     3 LGKGSFGKVMLARLKESGRLYAVKVLKKDVILQD---------DDVECTM--TEKRILSLAR-----------NHPFLTQ 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDPaeDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd05590    61 LYCCFQTP--DRLFFVMEFVNGGDLMfHIQKSRRFDEARARFYAAEITSALMFLHDKGIIYRDLKLDNVLLDHEGHCKLA 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGVSNQFEGNDAQLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVF 372
Cdd:cd05590   139 DFGMCKEGIFNGKTTSTFCGTPDYIAPEILQ---EMLYGPSVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVY 215
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1384865967 373 PEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKH 412
Cdd:cd05590   216 PT--WLSQDAVDILKAFMTKNPTMRLGSLTLGGEEAILRH 253
STKc_PAK6 cd06659
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the ...
194-413 3.40e-25

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK6 may play a role in stress responses through its activation by the mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 6 (MKK6) pathway. PAK6 is highly expressed in the brain. It is not required for viability, but together with PAK5, it is required for normal levels of locomotion and activity, and for learning and memory. Increased expression of PAK6 is found in primary and metastatic prostate cancer. PAK6 may play a role in the regulation of motility. PAK6 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270821 [Multi-domain]  Cd Length: 297  Bit Score: 105.45  E-value: 3.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:cd06659    63 ELLFNEVVIMRDYQHPNVVEMYKSY--LVGEELWVLMEYLQGGALTDIVSQTRLNEEQIATVCEAVLQALAYLHSQGVIH 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATGVTLYCFVYGKCPF 353
Cdd:cd06659   141 RDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVIS---RCPYGTEVDIWSLGIMVIEMVDGEPPY 217
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 354 IDDYILTLHRKIKNE-AVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHG 413
Cdd:cd06659   218 FSDSPVQAMKRLRDSpPPKLKNSHKASPVLRDFLERMLVRDPQERATAQELLDHPFLLQTG 278
STKc_SHIK cd13974
Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase; STKs ...
244-403 3.82e-25

Catalytic domain of the Serine/Threonine kinase, SINK-homologous inhibitory kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SHIK, also referred to as STK40 or LYK4, is a cytoplasmic and nuclear protein that is involved in the negative regulation of NF-kappaB- and p53-mediated transcription. It was identified as a protein related to SINK, a p65-interacting protein that inhibits p65 phosphorylation by the catalytic subunit of PKA, thereby inhibiting transcriptional competence of NF-kappaB. The SHIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270876 [Multi-domain]  Cd Length: 290  Bit Score: 105.18  E-value: 3.82e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 244 DKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGH-VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI 322
Cdd:cd13974   126 EKRLSEREALVIFYDVVRVVEALHKKNIVHRDLKLGNMVLNKRTRkITITNFCLGKHLVSEDDLLKDQRGSPAYISPDVL 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 323 SdsGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSD 402
Cdd:cd13974   206 S--GKPYLGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLNPQKRLTASE 283

                  .
gi 1384865967 403 I 403
Cdd:cd13974   284 V 284
STKc_CDK4 cd07863
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs ...
127-408 4.18e-25

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 partners with all three D-type cyclins (D1, D2, and D3) and is also regulated by INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein and plays a role in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the nucleus. CDK4 also shows kinase activity towards Smad3, a signal transducer of TGF-beta signaling which modulates transcription and plays a role in cell proliferation and apoptosis. CDK4 is inhibited by the p21 inhibitor and is specifically mutated in human melanoma. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143368 [Multi-domain]  Cd Length: 288  Bit Score: 105.04  E-value: 4.18e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrppprgsQATQGGpakqlLPLERVyQEIAILKKL 206
Cdd:cd07863     1 QYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRV------------------QTNEDG-----LPLSTV-REVALLKRL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 ---DHVNVVKLIEV---LDDPAEDNLYLVF-----DL---LRKGPVMEVPCDKpfpeeqARLYLRDIILGLEYLHCQKIV 272
Cdd:cd07863    57 eafDHPNIVRLMDVcatSRTDRETKVTLVFehvdqDLrtyLDKVPPPGLPAET------IKDLMRQFLRGLDFLHANCIV 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATGVT---------L 343
Cdd:cd07863   131 HRDLKPENILVTSGGQVKLADFGLARIYSCQMA-LTPVVVTLWYRAPEVLL---QSTYATPVDMWSVGCIfaemfrrkpL 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 344 YC-----------FVYGKCPFIDDYI--LTLHRKIKNEAVVFPEE---PEVSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd07863   207 FCgnseadqlgkiFDLIGLPPEDDWPrdVTLPRGAFSPRGPRPVQsvvPEIEESGAQLLLEMLTFNPHKRISAFRALQHP 286

                  .
gi 1384865967 408 W 408
Cdd:cd07863   287 F 287
STKc_MAPKAPK3 cd14172
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
244-409 4.24e-25

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 3 (MAPKAP3 or MK3) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK3 is a bonafide substrate for the MAPK p38. It is closely related to MK2 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK3 activity is only significant when MK2 is absent. The MK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271074 [Multi-domain]  Cd Length: 267  Bit Score: 104.30  E-value: 4.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 244 DKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL---GDDGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPE 320
Cdd:cd14172    97 DQAFTEREASEIMRDIGTAIQYLHSMNIAHRDVKPENLLYtskEKDAVLKLTDFGFAKETTVQNA-LQTPCYTPYYVAPE 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 321 AIsdsGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILT----LHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNP 394
Cdd:cd14172   176 VL---GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAispgMKRRIRMGQYGFpnPEWAEVSEEAKQLIRHLLKTDP 252
                         170
                  ....*....|....*
gi 1384865967 395 ETRIGVSDIKLHPWV 409
Cdd:cd14172   253 TERMTITQFMNHPWI 267
STKc_MSK2_C cd14180
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
198-409 4.67e-25

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271082 [Multi-domain]  Cd Length: 309  Bit Score: 105.34  E-value: 4.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLD-HVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd14180    49 REVAALRLCQsHPNIVALHEVLHD--QYHTYLVMELLRGGELLDrIKKKARFSESEASQLMRSLVSAVSFMHEAGVVHRD 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLLGDDGH---VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCP 352
Cdd:cd14180   127 LKPENILYADESDgavLKVIDFGFARLRPQGSRPLQTPCFTLQYAAPELFSNQGYD---ESCDLWSLGVILYTMLSGQVP 203
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 353 F-------IDDYILTLHRKIKNEAvvFPEEPE----VSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14180   204 FqskrgkmFHNHAADIMHKIKEGD--FSLEGEawkgVSEEAKDLVRGLLTVDPAKRLKLSELRESDWL 269
STKc_beta_ARK cd05606
Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs ...
247-408 5.20e-25

Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The beta-ARK group is composed of GRK2, GRK3, and similar proteins. GRK2 and GRK3 are both widely expressed in many tissues, although GRK2 is present at higher levels. They contain an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRK2 (also called beta-ARK or beta-ARK1) is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The beta-ARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270757 [Multi-domain]  Cd Length: 279  Bit Score: 104.44  E-value: 5.20e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 247 FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFegNDAQLSSTAGTPAFMAPEAISdSG 326
Cdd:cd05606    95 FSEAEMRFYAAEVILGLEHMHNRFIVYRDLKPANILLDEHGHVRISDLGLACDF--SKKKPHASVGTHGYMAPEVLQ-KG 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 327 QSFSGKAlDVWATGVTLYCFVYGKCPF----------IDDYILTLhrkikneAVVFPEepEVSEDLKDLILRMLDKNPET 396
Cdd:cd05606   172 VAYDSSA-DWFSLGCMLYKLLKGHSPFrqhktkdkheIDRMTLTM-------NVELPD--SFSPELKSLLEGLLQRDVSK 241
                         170
                  ....*....|....*..
gi 1384865967 397 RIG-----VSDIKLHPW 408
Cdd:cd05606   242 RLGclgrgATEVKEHPF 258
STKc_DRAK1 cd14197
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
133-409 5.69e-25

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 (also called STK17A) and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. Rabbit DRAK1 has been shown to induce apoptosis in osteoclasts and overexpressio of human DRAK1 induces apoptosis in cultured fibroblast cells. DRAK1 may be involved in apoptotic signaling. The DRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271099 [Multi-domain]  Cd Length: 271  Bit Score: 104.25  E-value: 5.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 133 EIGKGAYGVVRLAYNESEDRHYAmkvlskkkllKQYGFPRRpppRGSQATQggpakqllpleRVYQEIAILK-KLDHVNV 211
Cdd:cd14197    16 ELGRGKFAVVRKCVEKDSGKEFA----------AKFMRKRR---KGQDCRM-----------EIIHEIAVLElAQANPWV 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 212 VKLIEVLDDPAEdnLYLVFDLLRKGPVMEvPC----DKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD- 286
Cdd:cd14197    72 INLHEVYETASE--MILVLEYAAGGEIFN-QCvadrEEAFKEKDVKRLMKQILEGVSFLHNNNVVHLDLKPQNILLTSEs 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 --GHVKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFsgkALDVWATGVTLYCFVYGKCPFIDDYILTLHRK 364
Cdd:cd14197   149 plGDIKIVDFGLS-RILKNSEELREIMGTPEYVAPEILSYEPIST---ATDMWSIGVLAYVMLTGISPFLGDDKQETFLN 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1384865967 365 IKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14197   225 ISQMNVSYSEEefEHLSESAIDFIKTLLIKKPENRATAEDCLKHPWL 271
STKc_cPKC cd05587
Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; ...
223-408 6.12e-25

Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. cPKCs are potent kinases for histones, myelin basic protein, and protamine. They depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. cPKCs contain a calcium-binding C2 region in their regulatory domain. There are four cPKC isoforms, named alpha, betaI, betaII, and gamma. PKC-gamma is mainly expressed in neuronal tissues. It plays a role in protection from ischemia. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The cPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270739 [Multi-domain]  Cd Length: 320  Bit Score: 105.17  E-value: 6.12e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
Cdd:cd05587    69 MDRLYFVMEYVNGGDLMyHIQQVGKFKEPVAVFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLDAEGHIKIADFGMCKEGI 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 302 GNDAQLSSTAGTPAFMAPEAISDsgQSFsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSED 381
Cdd:cd05587   149 FGGKTTRTFCGTPDYIAPEIIAY--QPY-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPK--SLSKE 223
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1384865967 382 LKDLILRMLDKNPETRIGVS-----DIKLHPW 408
Cdd:cd05587   224 AVSICKGLLTKHPAKRLGCGptgerDIKEHPF 255
STKc_myosinIIIB_N cd06639
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze ...
134-409 6.78e-25

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIB myosin is expressed highly in retina. It is also present in the brain and testis. The human class IIIB myosin gene maps to a region that overlaps the locus for Bardet-Biedl syndrome, which is characterized by dysmorphic extremities, retinal dystrophy, obesity, male hypogenitalism, and renal abnormalities. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. They may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. They may also function as cargo carriers during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270808 [Multi-domain]  Cd Length: 291  Bit Score: 104.30  E-value: 6.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEdrhyamkvlskkkllkqygfprrppprGSQATqggpAKQLLPLERVYQEIA----ILKKL-DH 208
Cdd:cd06639    30 IGKGTYGKVYKVTNKKD---------------------------GSLAA----VKILDPISDVDEEIEaeynILRSLpNH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 209 VNVVKLIEVL---DDPAEDNLYLVFDLLRKGPVMEV-----PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSN 280
Cdd:cd06639    79 PNVVKFYGMFykaDQYVGGQLWLVLELCNGGSVTELvkgllKCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNN 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 281 LLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQ---SFSGKAlDVWATGVTLYCFVYGKCPFIDDY 357
Cdd:cd06639   159 ILLTTEGGVKLVDFGVSAQLTSARLRRNTSVGTPFWMAPEVIACEQQydySYDARC-DVWSLGITAIELADGDPPLFDMH 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 358 -ILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06639   238 pVKALFKIPRNPPPTLLNPEKWCRGFSHFISQCLIKDFEKRPSVTHLLEHPFI 290
STKc_STK25 cd06642
Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); ...
193-412 7.74e-25

Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK25 is also called Ste20/oxidant stress response kinase 1 (SOK1) or yeast Sps1/Ste20-related kinase 1 (YSK1). It is localized in the Golgi apparatus through its interaction with the Golgi matrix protein GM130. It may be involved in the regulation of cell migration and polarization. STK25 binds and phosphorylates CCM3 (cerebral cavernous malformation 3), also called PCD10 (programmed cell death 10), and may play a role in apoptosis. Human STK25 is a candidate gene responsible for pseudopseudohypoparathyroidism (PPHP), a disease that shares features with the Albright hereditary osteodystrophy (AHO) phenotype. The STK25 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270810 [Multi-domain]  Cd Length: 277  Bit Score: 103.98  E-value: 7.74e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd06642    46 IEDIQQEITVLSQCDSPYITRYYGSYLKGTK--LWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKI 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGkalDVWATGVTLYCFVYGKCP 352
Cdd:cd06642   124 HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKA---DIWSLGITAIELAKGEPP 200
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 353 FIDDYILTLHRKI-KNEAVVFpeEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKH 412
Cdd:cd06642   201 NSDLHPMRVLFLIpKNSPPTL--EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRY 259
STKc_16 cd13986
Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the ...
128-403 8.00e-25

Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK16 is associated with many names including Myristylated and Palmitylated Serine/threonine Kinase 1 (MPSK1), Kinase related to cerevisiae and thaliana (Krct), and Protein Kinase expressed in day 12 fetal liver (PKL12). It is widely expressed in mammals with highest levels found in liver, testis, and kidney. It is localized in the Golgi but is translocated to the nucleus upon disorganization of the Golgi. STK16 is constitutively active and is capable of phosphorylating itself and other substrates. It may be involved in regulating stromal-epithelial interactions during mammary gland ductal morphogenesis. It may also function as a transcriptional co-activator of type-C natriuretic peptide and VEGF. The STK16 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270888 [Multi-domain]  Cd Length: 282  Bit Score: 103.91  E-value: 8.00e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpaKQLL-----PLERVYQEIAI 202
Cdd:cd13986     2 YRIQRLLGEGGFSFVYLVEDLSTGRLYAL-------------------------------KKILchskeDVKEAMREIEN 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 203 LKKLDHVNVVKLIE---VLDDPAEDNLYLVFDLLRKGPV---MEVPCDK--PFPEEQARLYLRDIILGLEYLHCQKIV-- 272
Cdd:cd13986    51 YRLFNHPNILRLLDsqiVKEAGGKKEVYLLLPYYKRGSLqdeIERRLVKgtFFPEDRILHIFLGICRGLKAMHEPELVpy 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 -HRDIKPSNLLLGDDGHVKIADFGVSNQ----FEGN-DAQ----LSSTAGTPAFMAPEAIS-DSGQSFSGKAlDVWATGV 341
Cdd:cd13986   131 aHRDIKPGNVLLSEDDEPILMDLGSMNParieIEGRrEALalqdWAAEHCTMPYRAPELFDvKSHCTIDEKT-DIWSLGC 209
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 342 TLYCFVYGKCPFidDYIL----TLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd13986   210 TLYALMYGESPF--ERIFqkgdSLALAVLSGNYSFPDNSRYSEELHQLVKSMLVVNPAERPSIDDL 273
STKc_SPEG_rpt1 cd14108
Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle ...
128-408 9.50e-25

Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271010 [Multi-domain]  Cd Length: 255  Bit Score: 103.06  E-value: 9.50e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPPPRGSqatqggpakqllplerVYQEIAILKKLD 207
Cdd:cd14108     4 YDIHKEIGRGAFSYLRRVKEKSSDLSFAAKF-----------IPVRAKKKTS----------------ARRELALLAELD 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDG 287
Cdd:cd14108    57 HKSIVRFHDAFE--KRRVVIIVTELCHEELLERITKRPTVCESEVRSYMRQLLEGIEYLHQNDVLHLDLKPENLLMADQK 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 288 --HVKIADFGVSNQFEGNDAQLSSTaGTPAFMAPEAISdsgQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKI 365
Cdd:cd14108   135 tdQVRICDFGNAQELTPNEPQYCKY-GTPEFVAPEIVN---QSPVSKVTDIWPVGVIAYLCLTGISPFVGENDRTTLMNI 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1384865967 366 KNEAVVFPEE--PEVSEDLKDLILRMLDKNpETRIGVSDIKLHPW 408
Cdd:cd14108   211 RNYNVAFEESmfKDLCREAKGFIIKVLVSD-RLRPDAEETLEHPW 254
PLN00034 PLN00034
mitogen-activated protein kinase kinase; Provisional
198-411 1.17e-24

mitogen-activated protein kinase kinase; Provisional


Pssm-ID: 215036 [Multi-domain]  Cd Length: 353  Bit Score: 104.91  E-value: 1.17e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFdlLRKGPVMEVPC-DKPFPEEQARlylrDIILGLEYLHCQKIVHRDI 276
Cdd:PLN00034  121 REIEILRDVNHPNVVKCHDMFDHNGEIQVLLEF--MDGGSLEGTHIaDEQFLADVAR----QILSGIAYLHRRHIVHRDI 194
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAI-SDSGQ-SFSGKALDVWATGVTLYCFVYGKCPFI 354
Cdd:PLN00034  195 KPSNLLINSAKNVKIADFGVSRILAQTMDPCNSSVGTIAYMSPERInTDLNHgAYDGYAGDIWSLGVSILEFYLGRFPFG 274
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 355 ----DDYILTLHrkikneAVVFPEEPE----VSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTK 411
Cdd:PLN00034  275 vgrqGDWASLMC------AICMSQPPEapatASREFRHFISCCLQREPAKRWSAMQLLQHPFILR 333
STKc_CDK2_3 cd07860
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; ...
133-408 1.49e-24

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. CDK2, together with CDK4, also regulates embryonic cell proliferation. Despite these important roles, mice deleted for the cdk2 gene are viable and normal except for being sterile. This may be due to compensation provided by CDK1 (also called Cdc2), which can also bind cyclin E and drive the G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270844 [Multi-domain]  Cd Length: 284  Bit Score: 103.35  E-value: 1.49e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 133 EIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLlplervyQEIAILKKLDHVNVV 212
Cdd:cd07860     7 KIGEGTYGVVYKARNKLTGEVVALKKI-----------------RLDTETEGVPSTAI-------REISLLKELNHPNIV 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 213 KLIEVLDdpAEDNLYLVFDLLRKG--PVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVK 290
Cdd:cd07860    63 KLLDVIH--TENKLYLVFEFLHQDlkKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIK 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 291 IADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFI-DDYILTLHRKIK--- 366
Cdd:cd07860   141 LADFGLARAFGVPVRTYTHEVVTLWYRAPEIL--LGCKYYSTAVDIWSLGCIFAEMVTRRALFPgDSEIDQLFRIFRtlg 218
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 367 --NEAV------------VFPE---------EPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd07860   219 tpDEVVwpgvtsmpdykpSFPKwarqdfskvVPPLDEDGRDLLSQMLHYDPNKRISAKAALAHPF 283
STKc_SGK1 cd05602
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
134-402 1.50e-24

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK1 is ubiquitously expressed and is under transcriptional control of numerous stimuli including cell stress (cell shrinkage), serum, hormones (gluco- and mineralocorticoids), gonadotropins, growth factors, interleukin-6, and other cytokines. It plays roles in sodium retention and potassium elimination in the kidney, nutrient transport, salt sensitivity, memory consolidation, and cardiac repolarization. A common SGK1 variant is associated with increased blood pressure and body weight. SGK1 may also contribute to tumor growth, neurodegeneration, fibrosing disease, and ischemia. The SGK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270753 [Multi-domain]  Cd Length: 339  Bit Score: 104.33  E-value: 1.50e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpakqllpleRVYQEIAILKKLDHVNVVK 213
Cdd:cd05602    15 IGKGSFGKVLLARHKSDEKFYAV--------------------------------------KVLQKKAILKKKEEKHIMS 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 ----LIEVLDDP----------AEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKP 278
Cdd:cd05602    57 ernvLLKNVKHPflvglhfsfqTTDKLYFVLDYINGGELFyHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKP 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 279 SNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDsgQSFSgKALDVWATGVTLYCFVYGKCPFIDDYI 358
Cdd:cd05602   137 ENILLDSQGHIVLTDFGLCKENIEPNGTTSTFCGTPEYLAPEVLHK--QPYD-RTVDWWCLGAVLYEMLYGLPPFYSRNT 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1384865967 359 LTLHRKIKNEAVVFpeEPEVSEDLKDLILRMLDKNPETRIGVSD 402
Cdd:cd05602   214 AEMYDNILNKPLQL--KPNITNSARHLLEGLLQKDRTKRLGAKD 255
PK_TRB3 cd14024
Pseudokinase domain of Tribbles Homolog 3; The pseudokinase domain shows similarity to protein ...
189-409 2.34e-24

Pseudokinase domain of Tribbles Homolog 3; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. TRB3 binds and regulates ATF4, p65/RelA, and PKB (or Akt). It negatively regulates ATF4-mediated gene expression including that of CHOP (C/EBP homologous protein) and HO-1, which are both involved in modulating apoptosis. It also inhibits insulin-mediated phosphorylation of PKB and is a possible determinant of insulin resistance and related disorders. In osteoarthritic chondrocytes where it inhibits insulin-like growth factor 1-mediated cell survival, TRB3 is overexpressed, resulting in increased cell death. TRB3 is one of three Tribbles Homolog (TRB) proteins present in vertebrates that are encoded by three separate genes. TRB proteins interact with many proteins involved in signalling pathways. They play scaffold-like regulatory functions and affect many cellular processes such as mitosis, apoptosis, and gene expression. The TRB3 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270926 [Multi-domain]  Cd Length: 242  Bit Score: 101.49  E-value: 2.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 189 QLLPLERVYQEIAILKKL-DHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLH 267
Cdd:cd14024    24 KVLSLRSYQECLAPYDRLgPHEGVCSVLEVV--IGQDRAYAFFSRHYGDMHSHVRRRRRLSEDEARGLFTQMARAVAHCH 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 268 CQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF--EGNDAQLSSTAGTPAFMAPEAISdSGQSFSGKALDVWATGVTLYC 345
Cdd:cd14024   102 QHGVILRDLKLRRFVFTDELRTKLVLVNLEDSCplNGDDDSLTDKHGCPAYVGPEILS-SRRSYSGKAADVWSLGVCLYT 180
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 346 FVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14024   181 MLLGRYPFQDTEPAALFAKIRRGAFSLPA--WLSPGARCLVSCMLRRSPAERLKASEILLHPWL 242
STKc_MAPKAPK5 cd14171
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
207-409 3.08e-24

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 5 (MAPKAP5 or MK5) is also called PRAK (p38-regulated/activated protein kinase). It contains a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271073 [Multi-domain]  Cd Length: 289  Bit Score: 102.54  E-value: 3.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEV----LDDPAEDN----LYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd14171    57 GHPNIVQIYDVyansVQFPGESSprarLLIVMELMEGGELFDrISQHRHFTEKQAAQYTKQIALAVQHCHSLNIAHRDLK 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 278 PSNLLLGD---DGHVKIADFGVSNQFEGNdaqLSSTAGTPAFMAP---EAISDSGQSFSG-----------KALDVWATG 340
Cdd:cd14171   137 PENLLLKDnseDAPIKLCDFGFAKVDQGD---LMTPQFTPYYVAPqvlEAQRRHRKERSGiptsptpytydKSCDMWSLG 213
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 341 VTLYCFVYGKCPFIDDY-----ILTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14171   214 VIIYIMLCGYPPFYSEHpsrtiTKDMKRKIMTGSYEFPEEewSQISEMAKDIVRKLLCVDPEERMTIEEVLHHPWL 289
STKc_PAK1 cd06654
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the ...
183-409 4.19e-24

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK1 is important in the regulation of many cellular processes including cytoskeletal dynamics, cell motility, growth, and proliferation. Although PAK1 has been regarded mainly as a cytosolic protein, recent reports indicate that PAK1 also exists in significant amounts in the nucleus, where it is involved in transcription modulation and in cell cycle regulatory events. PAK1 is also involved in transformation and tumorigenesis. Its overexpression, hyperactivation and increased nuclear accumulation is correlated to breast cancer invasiveness and progression. Nuclear accumulation is also linked to tamoxifen resistance in breast cancer cells. PAK1 belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270820 [Multi-domain]  Cd Length: 296  Bit Score: 102.11  E-value: 4.19e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 183 QGGPAKQLlplerVYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILG 262
Cdd:cd06654    56 QQQPKKEL-----IINEILVMRENKNPNIVNYLDSY--LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVT 342
Cdd:cd06654   129 LEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY---GPKVDIWSLGIM 205
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 343 LYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPE-VSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06654   206 AIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEkLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFL 273
PTZ00426 PTZ00426
cAMP-dependent protein kinase catalytic subunit; Provisional
193-408 4.40e-24

cAMP-dependent protein kinase catalytic subunit; Provisional


Pssm-ID: 173616 [Multi-domain]  Cd Length: 340  Bit Score: 103.14  E-value: 4.40e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:PTZ00426   75 VDHVFSERKILNYINHPFCVNLYGSFKD--ESYLYLVLEFVIGGEFFTfLRRNKRFPNDVGCFYAAQIVLIFEYLQSLNI 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGVSNQFegnDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKC 351
Cdd:PTZ00426  153 VYRDLKPENLLLDKDGFIKMTDFGFAKVV---DTRTYTLCGTPEYIAPEILLNVGH---GKAADWWTLGIFIYEILVGCP 226
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 352 PFIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRI-----GVSDIKLHPW 408
Cdd:PTZ00426  227 PFYANEPLLIYQKILEGIIYFPK--FLDNNCKHLMKKLLSHDLTKRYgnlkkGAQNVKEHPW 286
STKc_TBK1 cd13988
Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the ...
192-353 4.91e-24

Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TBK1 is also called T2K and NF-kB-activating kinase. It is widely expressed in most cell types and acts as an IkappaB kinase (IKK)-activating kinase responsible for NF-kB activation in response to growth factors. It plays a role in modulating inflammatory responses through the NF-kB pathway. TKB1 is also a major player in innate immune responses since it functions as a virus-activated kinase necessary for establishing an antiviral state. It phosphorylates IRF-3 and IRF-7, which are important transcription factors for inducing type I interferon during viral infection. In addition, TBK1 may also play roles in cell transformation and oncogenesis. The TBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270890 [Multi-domain]  Cd Length: 316  Bit Score: 102.57  E-value: 4.91e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 192 PLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVpCDKP-----FPEEQARLYLRDIILGLEYL 266
Cdd:cd13988    34 PLDVQMREFEVLKKLNHKNIVKLFAIEEELTTRHKVLVMELCPCGSLYTV-LEEPsnaygLPESEFLIVLRDVVAGMNHL 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 267 HCQKIVHRDIKPSNLL--LGDDGHV--KIADFGVSNQFEgNDAQLSSTAGTPAFMAPE----AI--SDSGQSFsGKALDV 336
Cdd:cd13988   113 RENGIVHRDIKPGNIMrvIGEDGQSvyKLTDFGAARELE-DDEQFVSLYGTEEYLHPDmyerAVlrKDHQKKY-GATVDL 190
                         170
                  ....*....|....*..
gi 1384865967 337 WATGVTLYCFVYGKCPF 353
Cdd:cd13988   191 WSIGVTFYHAATGSLPF 207
STKc_CDK10 cd07845
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs ...
199-422 6.04e-24

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK10, also called PISSLRE, is essential for cell growth and proliferation, and acts through the G2/M phase of the cell cycle. CDK10 has also been identified as an important factor in endocrine therapy resistance in breast cancer. CDK10 silencing increases the transcription of c-RAF and the activation of the p42/p44 MAPK pathway, which leads to antiestrogen resistance. Patients who express low levels of CDK10 relapse early on tamoxifen. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK10 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173742 [Multi-domain]  Cd Length: 309  Bit Score: 102.06  E-value: 6.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPAEDNLYLVF-----DLLRKgpVMEVPCdkPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:cd07845    56 EITLLLNLRHPNIVELKEVVVGKHLDSIFLVMeyceqDLASL--LDNMPT--PFSESQVKCLMLQLLRGLQYLHENFIIH 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKcPF 353
Cdd:cd07845   132 RDLKVSNLLLTDKGCLKIADFGLARTYGLPAKPMTPKVVTLWYRAPELL--LGCTTYTTAIDMWAVGCILAELLAHK-PL 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 354 I-------------------DDYILTLHRKIKN-EAVVFPEEP---------EVSEDLKDLILRMLDKNPETRIGVSDIK 404
Cdd:cd07845   209 LpgkseieqldliiqllgtpNESIWPGFSDLPLvGKFTLPKQPynnlkhkfpWLSEAGLRLLNFLLMYDPKKRATAEEAL 288
                         250
                  ....*....|....*...
gi 1384865967 405 LHPWVTkhgEEPLPSEEE 422
Cdd:cd07845   289 ESSYFK---EKPLPCEPE 303
STKc_MAK_like cd07830
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs ...
128-408 7.42e-24

Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of human MAK and MAK-related kinase (MRK), Saccharomyces cerevisiae Ime2p, Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1, Caenorhabditis elegans dyf-5, Arabidopsis thaliana MHK, and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase, but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK, also called Intestinal Cell Kinase (ICK), is expressed ubiquitously, with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia, suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270824 [Multi-domain]  Cd Length: 283  Bit Score: 101.07  E-value: 7.42e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYA---MKvlskkkllkqygfprrppprgsqatqggpaKQLLPLERVYQ--EIAI 202
Cdd:cd07830     1 YKVIKQLGDGTFGSVYLARNKETGELVAikkMK------------------------------KKFYSWEECMNlrEVKS 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 203 LKKL-DHVNVVKLIEVLDDpaEDNLYLVFDLL----------RKGpvmevpcdKPFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd07830    51 LRKLnEHPNIVKLKEVFRE--NDELYFVFEYMegnlyqlmkdRKG--------KPFSESVIRSIIYQILQGLAHIHKHGF 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAISDSgQSFSgKALDVWATG---VTLY---- 344
Cdd:cd07830   121 FHRDLKPENLLVSGPEVVKIADFGLAREIR-SRPPYTDYVSTRWYRAPEILLRS-TSYS-SPVDIWALGcimAELYtlrp 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 345 --------------CFVYG---KCPFIDDYIL--TLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd07830   198 lfpgsseidqlykiCSVLGtptKQDWPEGYKLasKLGFRFPQFAPTSLHQliPNASPEAIDLIKDMLRWDPKKRPTASQA 277

                  ....*
gi 1384865967 404 KLHPW 408
Cdd:cd07830   278 LQHPY 282
STKc_Nek3 cd08219
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
127-403 1.29e-23

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek3 is primarily localized in the cytoplasm and shows no cell cycle-dependent changes in its activity. It is present in the axons of neurons and affects morphogenesis and polarity through its regulation of microtubule acetylation. Nek3 modulates the signaling of the prolactin receptor through its activation of Vav2 and contributes to prolactin-mediated motility of breast cancer cells. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173759 [Multi-domain]  Cd Length: 255  Bit Score: 99.66  E-value: 1.29e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrppPRGSQATQGGpakqllplervYQEIAILKKL 206
Cdd:cd08219     1 QYNVLRVVGEGSFGRALLVQHVNSDQKYAMKEIRL--------------PKSSSAVEDS-----------RKEAVLLAKM 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVPCD---KPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd08219    56 KHPNIVAFKESFE--ADGHLYIVMEYCDGGDLMQKIKLqrgKLFPEDTILQWFVQMCLGVQHIHEKRVLHRDIKSKNIFL 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 GDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDsgQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLHR 363
Cdd:cd08219   134 TQNGKVKLGDFGSARLLTSPGAYACTYVGTPYYVPPEIWEN--MPYNNKS-DIWSLGCILYELCTLKHPFQANSWKNLIL 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1384865967 364 KIkNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd08219   211 KV-CQGSYKPLPSHYSYELRSLIKQMFKRNPRSRPSATTI 249
STKc_PAK3 cd06656
Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine ...
183-409 1.35e-23

Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine/threonine kinases (STKs), p21-activated kinase (PAK) 3, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. PAK3 belongs to group I. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation.


Pssm-ID: 132987 [Multi-domain]  Cd Length: 297  Bit Score: 100.95  E-value: 1.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 183 QGGPAKQLlplerVYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILG 262
Cdd:cd06656    55 QQQPKKEL-----IINEILVMRENKNPNIVNYLDSY--LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQA 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVT 342
Cdd:cd06656   128 LDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY---GPKVDIWSLGIM 204
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 343 LYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPE-VSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06656   205 AIEMVEGEPPYLNENPLRALYLIATNGTPELQNPErLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 272
PKc_Byr1_like cd06620
Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; ...
207-409 1.38e-23

Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Byr1 from Schizosaccharomyces pombe, FUZ7 from Ustilago maydis, and related proteins. Byr1 phosphorylates its downstream target, the MAPK Spk1, and is regulated by the MAPKK kinase Byr2. The Spk1 cascade is pheromone-responsive and is essential for sporulation and sexual differentiation in fission yeast. FUZ7 phosphorylates and activates its target, the MAPK Crk1, which is required in mating and virulence in U. maydis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The Byr-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270792 [Multi-domain]  Cd Length: 286  Bit Score: 100.59  E-value: 1.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAEDNLYLVFdllrkgpvmevpcdKPFPEEQARLYLRDIILGLEYLHCQ-KIVHRDIKPSNLLLGD 285
Cdd:cd06620    75 ENNNIIICMEYMDCGSLDKILKKK--------------GPFPEEVLGKIAVAVLEGLTYLYNVhRIIHRDIKPSNILVNS 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 286 DGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFID---------- 355
Cdd:cd06620   141 KGQIKLCDFGVSGELINSIAD--TFVGTSTYMSPERI--QGGKYSVKS-DVWSLGLSIIELALGEFPFAGsnddddgyng 215
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 356 -DYILTLHRKIKNE-AVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI-KLHPWV 409
Cdd:cd06620   216 pMGILDLLQRIVNEpPPRLPKDRIFPKDLRDFVDRCLLKDPRERPSPQLLlDHDPFI 272
STKc_MAPK15-like cd07852
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and ...
125-425 1.59e-23

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human MAPK15 is also called Extracellular signal Regulated Kinase 8 (ERK8) while the rat protein is called ERK7. ERK7 and ERK8 display both similar and different biochemical properties. They autophosphorylate and activate themselves and do not require upstream activating kinases. ERK7 is constitutively active and is not affected by extracellular stimuli whereas ERK8 shows low basal activity and is activated by DNA-damaging agents. ERK7 and ERK8 also have different substrate profiles. Genome analysis shows that they are orthologs with similar gene structures. ERK7 and ERK 8 may be involved in the signaling of some nuclear receptor transcription factors. ERK7 regulates hormone-dependent degradation of estrogen receptor alpha while ERK8 down-regulates the transcriptional co-activation androgen and glucocorticoid receptors. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK15 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270841 [Multi-domain]  Cd Length: 337  Bit Score: 101.48  E-value: 1.59e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqYG-FprrpppRGSQATQggpakqllpleRVYQEIAIL 203
Cdd:cd07852     6 LRRYEILKKLGKGAYGIVWKAIDKKTGEVVALKKI--------FDaF------RNATDAQ-----------RTFREIMFL 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 204 KKL-DHVNVVKLIEVLddPAEDN--LYLVFDLL--------RKGPVMEVpcdkpfpeeQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd07852    61 QELnDHPNIIKLLNVI--RAENDkdIYLVFEYMetdlhaviRANILEDI---------HKQYIMYQLLKALKYLHSGGVI 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFegndAQLSSTAGTPA---------FMAPEAISDSgQSFSgKALDVWATGVTL 343
Cdd:cd07852   130 HRDLKPSNILLNSDCRVKLADFGLARSL----SQLEEDDENPVltdyvatrwYRAPEILLGS-TRYT-KGVDMWSVGCIL 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 344 YCFVYGKCPF-----ID--DYILTLH-------------------------RKIKNEAVVFpeePEVSEDLKDLILRMLD 391
Cdd:cd07852   204 GEMLLGKPLFpgtstLNqlEKIIEVIgrpsaediesiqspfaatmleslppSRPKSLDELF---PKASPDALDLLKKLLV 280
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1384865967 392 KNPETRIGVSDIKLHPWVTK-HGeeplPSEEEHCS 425
Cdd:cd07852   281 FNPNKRLTAEEALRHPYVAQfHN----PADEPSLP 311
STKc_p38beta cd07878
Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase ...
127-421 1.95e-23

Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase (also called MAPK11); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38beta/MAPK11 is widely expressed in tissues and shows more similarity with p38alpha than with the other isoforms. Both are sensitive to pyridinylimidazoles and share some common substrates such as MAPK activated protein kinase 2 (MK2) and the transcription factors ATF2, c-Fos and, ELK-1. p38beta is involved in regulating the activation of the cyclooxygenase-2 promoter and the expression of TGFbeta-induced alpha-smooth muscle cell actin. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143383 [Multi-domain]  Cd Length: 343  Bit Score: 101.28  E-value: 1.95e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrppprgsqatqggPAKQLLPLERVYQEIAILKKL 206
Cdd:cd07878    16 RYQNLTPVGSGAYGSVCSAYDTRLRQKVAVKKLSR------------------------PFQSLIHARRTYRELRLLKHM 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAE----DNLYLVFDLLRKGPVMEVPCDKpFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:cd07878    72 KHENVIGLLDVFTPATSienfNEVYLVTNLMGADLNNIVKCQK-LSDEHVQFLIYQLLRGLKYIHSAGIIHRDLKPSNVA 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 LGDDGHVKIADFGVSNQfegNDAQLSSTAGTPAFMAPEAISDsgQSFSGKALDVWATGVTLYCFVYGKCPFI-DDYILTL 361
Cdd:cd07878   151 VNEDCELRILDFGLARQ---ADDEMTGYVATRWYRAPEIMLN--WMHYNQTVDIWSVGCIMAELLKGKALFPgNDYIDQL 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 362 HR--------------KIKNEAV-----VFPEEPEvsEDLK-----------DLILRMLDKNPETRIGVSDIKLHPWVTK 411
Cdd:cd07878   226 KRimevvgtpspevlkKISSEHArkyiqSLPHMPQ--QDLKkifrganplaiDLLEKMLVLDSDKRISASEALAHPYFSQ 303
                         330
                  ....*....|.
gi 1384865967 412 -HGEEPLPSEE 421
Cdd:cd07878   304 yHDPEDEPEAE 314
STKc_PAK4 cd06657
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the ...
194-413 2.20e-23

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK4 regulates cell morphology and cytoskeletal organization. It is essential for embryonic viability and proper neural development. Mice lacking PAK4 die due to defects in the fetal heart. In addition, their spinal cord motor neurons showed failure to differentiate and migrate. PAK4 also plays a role in cell survival and tumorigenesis. It is overexpressed in many primary tumors including colon, esophageal, and mammary tumors. PAK4 has also been implicated in viral and bacterial infection pathways. PAK4 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132988 [Multi-domain]  Cd Length: 292  Bit Score: 100.10  E-value: 2.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:cd06657    62 ELLFNEVVIMRDYQHENVVEMYNSY--LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLKALSVLHAQGVIH 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATGVTLYCFVYGKCPF 353
Cdd:cd06657   140 RDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELIS---RLPYGPEVDIWSLGIMVIEMVDGEPPY 216
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 354 IDDYILTLHRKIK-NEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHG 413
Cdd:cd06657   217 FNEPPLKAMKMIRdNLPPKLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAG 277
STKc_SPEG_rpt2 cd14111
Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle ...
128-409 2.41e-23

Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271013 [Multi-domain]  Cd Length: 257  Bit Score: 99.13  E-value: 2.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAyneSEDRHYAMkvlskkkllkqygFPRRPPPRGSQATQGGPakqllplervyQEIAILKKLD 207
Cdd:cd14111     5 YTFLDEKARGRFGVIRRC---RENATGKN-------------FPAKIVPYQAEEKQGVL-----------QEYEILKSLH 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDK-PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDD 286
Cdd:cd14111    58 HERIMALHEAYITPRY--LVLIAEFCSGKELLHSLIDRfRYSEDDVVGYLVQILQGLEYLHGRRVLHLDIKPDNIMVTNL 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 287 GHVKIADFGVSNQFEGND-AQLSSTAGTPAFMAPEAISDsgqSFSGKALDVWATGVTLYCFVYGKCPFID-DYILTLHRK 364
Cdd:cd14111   136 NAIKIVDFGSAQSFNPLSlRQLGRRTGTLEYMAPEMVKG---EPVGPPADIWSIGVLTYIMLSGRSPFEDqDPQETEAKI 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1384865967 365 IKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14111   213 LVAKFDAFKLYPNVSQSASLFLKKVLSSYPWSRPTTKDCFAHAWL 257
STKc_Mos cd13979
Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze ...
245-397 2.60e-23

Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mos (or c-Mos) is a germ-cell specific kinase that plays roles in both the release of primary arrest and the induction of secondary arrest in oocytes. It is expressed towards the end of meiosis I and is quickly degraded upon fertilization. It is a component of the cytostatic factor (CSF), which is responsible for metaphase II arrest. In addition, Mos activates a phoshorylation cascade that leads to the activation of the p34 subunit of MPF (mitosis-promoting factor or maturation promoting factor), a cyclin-dependent kinase that is responsible for the release of primary arrest in meiosis I. The Mos subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270881 [Multi-domain]  Cd Length: 265  Bit Score: 99.38  E-value: 2.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 245 KPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ-FEGNDAQ--LSSTAGTPAFMAPEA 321
Cdd:cd13979    98 EPLPLAHRILISLDIARALRFCHSHGIVHLDVKPANILISEQGVCKLCDFGCSVKlGEGNEVGtpRSHIGGTYTYRAPEL 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 322 IsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEavVFPEEPEVSED-----LKDLILRMLDKNPET 396
Cdd:cd13979   178 L--KGERVTPKA-DIYSFGITLWQMLTRELPYAGLRQHVLYAVVAKD--LRPDLSGLEDSefgqrLRSLISRCWSAQPAE 252

                  .
gi 1384865967 397 R 397
Cdd:cd13979   253 R 253
STKc_p38 cd07851
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs ...
112-421 2.92e-23

Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They function in the regulation of the cell cycle, cell development, cell differentiation, senescence, tumorigenesis, apoptosis, pain development and pain progression, and immune responses. p38 kinases are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. p38 substrates include other protein kinases and factors that regulate transcription, nuclear export, mRNA stability and translation. p38 kinases are drug targets for the inflammatory diseases psoriasis, rheumatoid arthritis, and chronic pulmonary disease. Vertebrates contain four isoforms of p38, named alpha, beta, gamma, and delta, which show varying substrate specificity and expression patterns. p38alpha and p38beta are ubiquitously expressed, p38gamma is predominantly found in skeletal muscle, and p38delta is found in the heart, lung, testis, pancreas, and small intestine. The p38 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143356 [Multi-domain]  Cd Length: 343  Bit Score: 100.83  E-value: 2.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 112 HRVAISDTEDCVQlNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfpRRPPPRGSQAtqggpakqll 191
Cdd:cd07851     2 YRQELNKTVWEVP-DRYQNLSPVGSGAYGQVCSAFDTKTGRKVAIKKL------------SRPFQSAIHA---------- 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 192 plERVYQEIAILKKLDHVNVVKLIEVL--DDPAED--NLYLVFDLLRK--GPVMEVpcdKPFPEEQARLYLRDIILGLEY 265
Cdd:cd07851    59 --KRTYRELRLLKHMKHENVIGLLDVFtpASSLEDfqDVYLVTHLMGAdlNNIVKC---QKLSDDHIQFLVYQILRGLKY 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQfegNDAQLSSTAGTPAFMAPEAISDSGQsfSGKALDVWATGVTLYC 345
Cdd:cd07851   134 IHSAGIIHRDLKPSNLAVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIMLNWMH--YNQTVDIWSVGCIMAE 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 346 FVYGKCPFI-DDYILTLHR--------------KIKNEAV-----------------VFpeePEVSEDLKDLILRMLDKN 393
Cdd:cd07851   209 LLTGKTLFPgSDHIDQLKRimnlvgtpdeellkKISSESArnyiqslpqmpkkdfkeVF---SGANPLAIDLLEKMLVLD 285
                         330       340
                  ....*....|....*....|....*....
gi 1384865967 394 PETRIGVSDIKLHPWVTK-HGEEPLPSEE 421
Cdd:cd07851   286 PDKRITAAEALAHPYLAEyHDPEDEPVAP 314
STKc_WNK cd13983
Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze ...
129-353 2.94e-23

Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNKs comprise a subfamily of STKs with an unusual placement of a catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. They are also involved in cell signaling, survival, proliferation, and organ development. WNKs are activated by hyperosmotic or low-chloride hypotonic stress and they function upstream of SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. There are four vertebrate WNKs which show varying expression patterns. WNK1 and WNK2 are widely expressed while WNK3 and WNK4 show a more restricted expression pattern. Because mutations in human WNK1 and WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension (due to increased sodium reabsorption) and hyperkalemia (due to impaired renal potassium secretion), there are more studies conducted on these two proteins, compared to WNK2 and WNK3. The WNK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270885 [Multi-domain]  Cd Length: 258  Bit Score: 98.84  E-value: 2.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 129 KLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrppprgsqatqggpaKQLLPLE--RVYQEIAILKKL 206
Cdd:cd13983     4 KFNEVLGRGSFKTVYRAFDTEEGIEVAWNEIKL--------------------------RKLPKAErqRFKQEIEILKSL 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQA-RLYLRDIILGLEYLHCQK--IVHRDIKPSNLLL 283
Cdd:cd13983    58 KHPNIIKFYDSWESKSKKEVIFITELMTSGTLKQYLKRFKRLKLKViKSWCRQILEGLNYLHTRDppIIHRDLKCDNIFI 137
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 284 -GDDGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAISDSgqsfSGKALDVWATGVTLYCFVYGKCPF 353
Cdd:cd13983   138 nGNTGEVKIGDLGLATLLRQSFAK--SVIGTPEFMAPEMYEEH----YDEKVDIYAFGMCLLEMATGEYPY 202
STKc_MAP4K3 cd06645
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
196-411 3.05e-23

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. MAP4K3 is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. mTOR regulates ribosome biogenesis and protein translation, and is frequently deregulated in cancer. MAP4Ks are involved in MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270812 [Multi-domain]  Cd Length: 272  Bit Score: 99.35  E-value: 3.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 196 VYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEV-PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd06645    55 VQQEIIMMKDCKHSNIVAYFGSY--LRRDKLWICMEFCGGGSLQDIyHVTGPLSESQIAYVSRETLQGLYYLHSKGKMHR 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFI 354
Cdd:cd06645   133 DIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF 212
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 355 DDY---ILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTK 411
Cdd:cd06645   213 DLHpmrALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 272
STKc_MAPKAPK2 cd14170
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
210-416 3.77e-23

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 2 (MAPKAP2 or MK2) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK2 is a bonafide substrate for the MAPK p38. It is closely related to MK3 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. The MK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271072 [Multi-domain]  Cd Length: 303  Bit Score: 99.72  E-value: 3.77e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 210 NVVKLIEVLDDPAEDN--LYLVFDLLRKGPV---MEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14170    56 HIVRIVDVYENLYAGRkcLLIVMECLDGGELfsrIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 D---DGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAIsdsGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILT- 360
Cdd:cd14170   136 SkrpNAILKLTDFGFAKETTSHNS-LTTPCYTPYYVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAi 211
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 361 ---LHRKIKNEAVVFP--EEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEEP 416
Cdd:cd14170   212 spgMKTRIRMGQYEFPnpEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVP 272
STKc_EIF2AK2_PKR cd14047
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
127-406 3.92e-23

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKR (or EIF2AK2) contains an N-terminal double-stranded RNA (dsRNA) binding domain and a C-terminal catalytic kinase domain. It is activated by dsRNA, which is produced as a replication intermediate in virally infected cells. It plays a key role in mediating innate immune responses to viral infection. PKR is also directly activated by PACT (protein activator of PKR) and heparin, and is inhibited by viral proteins and RNAs. PKR also regulates transcription and signal transduction in diseased cells, playing roles in tumorigenesis and neurodegenerative diseases. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PKR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270949 [Multi-domain]  Cd Length: 267  Bit Score: 98.72  E-value: 3.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygfprrppprgsqatqggpakqlLPLERVYQEIAILKKL 206
Cdd:cd14047     7 DFKEIELIGSGGFGQVFKAKHRIDGKTYAIKRVK------------------------------LNNEKAEREVKALAKL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDP--------------AEDNLYLVFDLLRKGP----VMEVPCDKPFPEEQARLYlRDIILGLEYLHC 268
Cdd:cd14047    57 DHPNIVRYNGCWDGFdydpetsssnssrsKTKCLFIQMEFCEKGTleswIEKRNGEKLDKVLALEIF-EQITKGVEYIHS 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 269 QKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAISDsgQSFsGKALDVWATGVTLYCFVY 348
Cdd:cd14047   136 KKLIHRDLKPSNIFLVDTGKVKIGDFGLVTSLK-NDGKRTKSKGTLSYMSPEQISS--QDY-GKEVDIYALGLILFELLH 211
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 349 gkcpFIDDYILT--LHRKIKNEAV--VFPEEPEVSEdlkDLILRMLDKNPETRIGVSDIKLH 406
Cdd:cd14047   212 ----VCDSAFEKskFWTDLRNGILpdIFDKRYKIEK---TIIKKMLSKKPEDRPNASEILRT 266
STKc_CDKL cd07833
Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs ...
126-343 4.20e-23

Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDKL1-5 and similar proteins. Some CDKLs, like CDKL1 and CDKL3, may be implicated in transformation and others, like CDKL3 and CDKL5, are associated with mental retardation when impaired. CDKL2 plays a role in learning and memory. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270827 [Multi-domain]  Cd Length: 288  Bit Score: 99.31  E-value: 4.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrpppRGSQATQGGPAKQLLPLervyQEIAILKK 205
Cdd:cd07833     1 NKYEVLGVVGEGAYGVVLKCRNKATGEIVAI--------------------KKFKESEDDEDVKKTAL----REVKVLRQ 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGpVMEVPCDKP--FPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd07833    57 LRHENIVNLKEAFR--RKGRLYLVFEYVERT-LLELLEASPggLPPDAVRSYIWQLLQAIAYCHSHNIIHRDIKPENILV 133
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 284 GDDGHVKIADFGVSNQF-EGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTL 343
Cdd:cd07833   134 SESGVLKLCDFGFARALtARPASPLTDYVATRWYRAPELL--VGDTNYGKPVDVWAIGCIM 192
STKc_Titin cd14104
Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the ...
127-415 4.77e-23

Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Titin, also called connectin, is a muscle-specific elastic protein and is the largest known protein to date. It contains multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains, and a single kinase domain near the C-terminus. It spans half of the sarcomere, the repeating contractile unit of striated muscle, and performs mechanical and catalytic functions. Titin contributes to the passive force generated when muscle is stretched during relaxation. Its kinase domain phosphorylates and regulates the muscle protein telethonin, which is required for sarcomere formation in differentiating myocytes. In addition, titin binds many sarcomere proteins and acts as a molecular scaffold for filament formation during myofibrillogenesis. The Titin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271006 [Multi-domain]  Cd Length: 277  Bit Score: 98.78  E-value: 4.77e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAmkvlskkkllkqygfprrppprGSQATQGGPAKQLlplerVYQEIAILKKL 206
Cdd:cd14104     1 KYMIAEELGRGQFGIVHRCVETSSKKTYM----------------------AKFVKVKGADQVL-----VKKEISILNIA 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEVPCDKPFPEEQARL--YLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14104    54 RHRNILRLHESFESH--EELVMIFEFISGVDIFERITTARFELNEREIvsYVRQVCEALEFLHSKNIGHFDIRPENIIYC 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 D--DGHVKIADFGVSNQFE-GNDAQLSSTagTPAFMAPEAISdsgQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTL 361
Cdd:cd14104   132 TrrGSYIKIIEFGQSRQLKpGDKFRLQYT--SAEFYAPEVHQ---HESVSTATDMWSLGCLVYVLLSGINPFEAETNQQT 206
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 362 HRKIKNEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEE 415
Cdd:cd14104   207 IENIRNAEYAFDDEAfkNISIEALDFVDRLLVKERKSRMTAQEALNHPWLKQGMET 262
STKc_cPKC_beta cd05616
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs ...
224-406 5.36e-23

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKC beta isoforms (I and II), generated by alternative splicing of a single gene, are preferentially activated by hyperglycemia-induced DAG (1,2-diacylglycerol) in retinal tissues. This is implicated in diabetic microangiopathy such as ischemia, neovascularization, and abnormal vasodilator function. PKC-beta also plays an important role in VEGF signaling. In addition, glucose regulates proliferation in retinal endothelial cells via PKC-betaI. PKC-beta is also being explored as a therapeutic target in cancer. It contributes to tumor formation and is involved in the tumor host mechanisms of inflammation and angiogenesis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG, and in most cases, phosphatidylserine (PS) for activation. The cPKC-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270767 [Multi-domain]  Cd Length: 323  Bit Score: 99.69  E-value: 5.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 224 DNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 302
Cdd:cd05616    74 DRLYFVMEYVNGGDLMyHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIW 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 303 NDAQLSSTAGTPAFMAPEAIsdSGQSFsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSEDL 382
Cdd:cd05616   154 DGVTTKTFCGTPDYIAPEII--AYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPK--SMSKEA 228
                         170       180
                  ....*....|....*....|....*....
gi 1384865967 383 KDLILRMLDKNPETRIGVS-----DIKLH 406
Cdd:cd05616   229 VAICKGLMTKHPGKRLGCGpegerDIKEH 257
STKc_CDK1_CdkB_like cd07835
Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of ...
134-408 5.80e-23

Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK, CDK2, and CDK3. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression while the CDK1/cyclin B complex is critical for G2 to M phase transition. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. Studies in knockout mice revealed that CDK1 can compensate for the loss of the cdk2 gene as it can also bind cyclin E and drive G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270829 [Multi-domain]  Cd Length: 283  Bit Score: 98.52  E-value: 5.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLlplervyQEIAILKKLDHVNVVK 213
Cdd:cd07835     7 IGEGTYGVVYKARDKLTGEIVALKKI-----------------RLETEDEGVPSTAI-------REISLLKELNHPNIVR 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDpaEDNLYLVFDL----LRKgpVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHV 289
Cdd:cd07835    63 LLDVVHS--ENKLYLVFEFldldLKK--YMDSSPLTGLDPPLIKSYLYQLLQGIAFCHSHRVLHRDLKPQNLLIDTEGAL 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 290 KIADFGVSNQFegndaqlsstaGTPA-----------FMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFI-DDY 357
Cdd:cd07835   139 KLADFGLARAF-----------GVPVrtythevvtlwYRAPEIL--LGSKHYSTPVDIWSVGCIFAEMVTRRPLFPgDSE 205
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 358 ILTLHRKIK-----NEAV------------VFPE---------EPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd07835   206 IDQLFRIFRtlgtpDEDVwpgvtslpdykpTFPKwarqdlskvVPSLDEDGLDLLSQMLVYDPAKRISAKAALQHPY 282
STKc_BUR1 cd07866
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), ...
121-340 7.02e-23

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), Bypass UAS Requirement 1, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BUR1, also called SGV1, is a yeast CDK that is functionally equivalent to mammalian CDK9. It associates with the cyclin BUR2. BUR genes were orginally identified in a genetic screen as factors involved in general transcription. The BUR1/BUR2 complex phosphorylates the C-terminal domain of RNA polymerase II. In addition, this complex regulates histone modification by phosporylating Rad6 and mediating the association of the Paf1 complex with chromatin. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The BUR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270849 [Multi-domain]  Cd Length: 311  Bit Score: 98.93  E-value: 7.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 121 DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKllkqygfprrppprgsqatqggpAKQLLPLErVYQEI 200
Cdd:cd07866     3 GCSKLRDYEILGKLGEGTFGEVYKARQIKTGRVVALKKILMHN-----------------------EKDGFPIT-ALREI 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 201 AILKKLDHVNVVKLIEVLDDPAEDNL-----------YLVFDLlrkGPVMEVPCDKpFPEEQARLYLRDIILGLEYLHCQ 269
Cdd:cd07866    59 KILKKLKHPNVVPLIDMAVERPDKSKrkrgsvymvtpYMDHDL---SGLLENPSVK-LTESQIKCYMLQLLEGINYLHEN 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 270 KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG-----------TPAFMAPEAIsdSGQSFSGKALDVWA 338
Cdd:cd07866   135 HILHRDIKAANILIDNQGILKIADFGLARPYDGPPPNPKGGGGggtrkytnlvvTRWYRPPELL--LGERRYTTAVDIWG 212

                  ..
gi 1384865967 339 TG 340
Cdd:cd07866   213 IG 214
STKc_GSK3 cd14137
The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze ...
127-407 8.54e-23

The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GSK3 is a mutifunctional kinase involved in many cellular processes including cell division, proliferation, differentiation, adhesion, and apoptosis. In plants, GSK3 plays a role in the response to osmotic stress. In Caenorhabditis elegans, it plays a role in regulating normal oocyte-to-embryo transition and response to oxidative stress. In Chlamydomonas reinhardtii, GSK3 regulates flagellar length and assembly. In mammals, there are two isoforms, GSK3alpha and GSK3beta, which show both distinct and redundant functions. The two isoforms differ mainly in their N-termini. They are both involved in axon formation and in Wnt signaling.They play distinct roles in cardiogenesis, with GSKalpha being essential in cardiomyocyte survival, and GSKbeta regulating heart positioning and left-right symmetry. GSK3beta was first identified as a regulator of glycogen synthesis, but has since been determined to play other roles. It regulates the degradation of beta-catenin and IkB. Beta-catenin is the main effector of Wnt, which is involved in normal haematopoiesis and stem cell function. IkB is a central inhibitor of NF-kB, which is critical in maintaining leukemic cell growth. GSK3beta is enriched in the brain and is involved in regulating neuronal signaling pathways. It is implicated in the pathogenesis of many diseases including Type II diabetes, obesity, mood disorders, Alzheimer's disease, osteoporosis, and some types of cancer, among others. The GSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271039 [Multi-domain]  Cd Length: 293  Bit Score: 98.34  E-value: 8.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAmkvlskkkllkqygfprrppprgsqatqggpakqllpLERVYQ-------E 199
Cdd:cd14137     5 SYTIEKVIGSGSFGVVYQAKLLETGEVVA-------------------------------------IKKVLQdkryknrE 47
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 200 IAILKKLDHVNVVKLI----EVLDDPAEDNLYLVFD--------LLRKGPVMEvpcdKPFPEEQARLYLRDIILGLEYLH 267
Cdd:cd14137    48 LQIMRRLKHPNIVKLKyffySSGEKKDEVYLNLVMEympetlyrVIRHYSKNK----QTIPIIYVKLYSYQLFRGLAYLH 123
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 268 CQKIVHRDIKPSNLLL-GDDGHVKIADFGVSNQFEGNDAQlSSTAGTPAFMAPEAISDSgQSFSGkALDVWATGVTLYCF 346
Cdd:cd14137   124 SLGICHRDIKPQNLLVdPETGVLKLCDFGSAKRLVPGEPN-VSYICSRYYRAPELIFGA-TDYTT-AIDIWSAGCVLAEL 200
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 347 VYGKCPFI-DDYILTLHRKIK-------------NEAVVFPEEPEV-------------SEDLKDLILRMLDKNPETRIG 399
Cdd:cd14137   201 LLGQPLFPgESSVDQLVEIIKvlgtptreqikamNPNYTEFKFPQIkphpwekvfpkrtPPDAIDLLSKILVYNPSKRLT 280

                  ....*...
gi 1384865967 400 VSDIKLHP 407
Cdd:cd14137   281 ALEALAHP 288
STKc_MOK cd07831
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs ...
197-408 8.74e-23

Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MOK, also called Renal tumor antigen 1 (RAGE-1), is widely expressed and is enriched in testis, kidney, lung, and brain. It is expressed in approximately 50% of renal cell carcinomas (RCC) and is a potential target for immunotherapy. MOK is stabilized by its association with the HSP90 molecular chaperone. It is induced by the transcription factor Cdx2 and may be involved in regulating intestinal epithelial development and differentiation. The MOK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270825 [Multi-domain]  Cd Length: 282  Bit Score: 98.11  E-value: 8.74e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 197 YQEIAILKKL-DHVNVVKLIEVLDDPAEDNLYLVFDLL----------RKgpvmevpcdKPFPEEQARLYLRDIILGLEY 265
Cdd:cd07831    45 LREIQALRRLsPHPNILRLIEVLFDRKTGRLALVFELMdmnlyelikgRK---------RPLPEKRVKNYMYQLLKSLDH 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLgDDGHVKIADFGvsnqfegndaQLSSTAGTPAFM---------APEAISDSGqsFSGKALDV 336
Cdd:cd07831   116 MHRNGIFHRDIKPENILI-KDDILKLADFG----------SCRGIYSKPPYTeyistrwyrAPECLLTDG--YYGPKMDI 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 337 WATGvtlycfvygkCPFIDdyILTLH------------RKIKN------EAVV------------FPEE---------PE 377
Cdd:cd07831   183 WAVG----------CVFFE--ILSLFplfpgtneldqiAKIHDvlgtpdAEVLkkfrksrhmnynFPSKkgtglrkllPN 250
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1384865967 378 VSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd07831   251 ASAEGLDLLKKLLAYDPDERITAKQALRHPY 281
STKc_SGK2 cd05603
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; ...
134-406 9.05e-23

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK2 shows a more restricted distribution than SGK1 and is most abundantly expressed in epithelial tissues including kidney, liver, pancreas, and the choroid plexus of the brain. In vitro cellular assays show that SGK2 can stimulate the activity of ion channels, the glutamate transporter EEAT4, and the glutamate receptors, GluR6 and GLUR1. The SGK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270754 [Multi-domain]  Cd Length: 321  Bit Score: 98.89  E-value: 9.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsqatqggpakqllpleRVYQEIAILKKLDHVNVVK 213
Cdd:cd05603     3 IGKGSFGKVLLAKRKCDGKFYAV--------------------------------------KVLQKKTILKKKEQNHIMA 44
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 ----LIEVLDDP----------AEDNLYLVFDLLRKGPV-MEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKP 278
Cdd:cd05603    45 ernvLLKNLKHPflvglhysfqTSEKLYFVLDYVNGGELfFHLQRERCFLEPRARFYAAEVASAIGYLHSLNIIYRDLKP 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 279 SNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDsgQSFSgKALDVWATGVTLYCFVYGKCPFIDDYI 358
Cdd:cd05603   125 ENILLDCQGHVVLTDFGLCKEGMEPEETTSTFCGTPEYLAPEVLRK--EPYD-RTVDWWCLGAVLYEMLYGLPPFYSRDV 201
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 359 LTLHRKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETRIGVS----DIKLH 406
Cdd:cd05603   202 SQMYDNILHKPLHLP--GGKTVAACDLLQGLLHKDQRRRLGAKadflEIKNH 251
STKc_PAK5 cd06658
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the ...
194-413 9.76e-23

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK5 is mainly expressed in the brain. It is not required for viability, but together with PAK6, it is required for normal levels of locomotion and activity, and for learning and memory. PAK5 cooperates with Inca (induced in neural crest by AP2) in the regulation of cell adhesion and cytoskeletal organization in the embryo and in neural crest cells during craniofacial development. PAK5 may also play a role in controlling the signaling of Raf-1, an effector of Ras, at the mitochondria. PAK5 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132989 [Multi-domain]  Cd Length: 292  Bit Score: 98.19  E-value: 9.76e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:cd06658    64 ELLFNEVVIMRDYHHENVVDMYNSY--LVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIH 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATGVTLYCFVYGKCPF 353
Cdd:cd06658   142 RDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS---RLPYGTEVDIWSLGIMVIEMIDGEPPY 218
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 354 IDDYILTLHRKIK-NEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHG 413
Cdd:cd06658   219 FNEPPLQAMRRIRdNLPPRVKDSHKVSSVLRGFLDLMLVREPSQRATAQELLQHPFLKLAG 279
STKc_TAO cd06607
Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs ...
133-411 1.10e-22

Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. They activate the MAPKs, p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating the respective MAP/ERK kinases (MEKs, also known as MKKs or MAPKKs), MEK3/MEK6 and MKK4/MKK7. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. Vertebrates contain three TAO subfamily members, named TAO1, TAO2, and TAO3. The TAO subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270784 [Multi-domain]  Cd Length: 258  Bit Score: 97.14  E-value: 1.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 133 EIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfpRRPPPRGSQATQggpakqllPLERVYQEIAILKKLDHVNVV 212
Cdd:cd06607     8 EIGHGSFGAVYYARNKRTSEVVAI---------------KKMSYSGKQSTE--------KWQDIIKEVKFLRQLRHPNTI 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 213 --KLIEVLDDPAednlYLVFD--LLRKGPVMEVPcDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGH 288
Cdd:cd06607    65 eyKGCYLREHTA----WLVMEycLGSASDIVEVH-KKPLQEVEIAAICHGALQGLAYLHSHNRIHRDVKAGNILLTEPGT 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 289 VKIADFGvsnqfegnDAQLSSTA----GTPAFMAPEAI--SDSGQsFSGKAlDVWATGVTLYCFVYGKCPFID-DYILTL 361
Cdd:cd06607   140 VKLADFG--------SASLVCPAnsfvGTPYWMAPEVIlaMDEGQ-YDGKV-DVWSLGITCIELAERKPPLFNmNAMSAL 209
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1384865967 362 HRKIKNEAVVFPEEpEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTK 411
Cdd:cd06607   210 YHIAQNDSPTLSSG-EWSDDFRNFVDSCLQKIPQDRPSAEDLLKHPFVTR 258
STKc_ERK1_2_like cd07849
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine ...
127-422 1.10e-22

Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1, ERK2, baker's yeast Fus3, and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors, differentiation stimuli, and cytokines, through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates, many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth, cell proliferation, and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined, it is known that ERK2 can maintain most functions in the absence of ERK1, and that the deletion of ERK2 is embryonically lethal. The MAPK, Fus3, regulates yeast mating processes including mating-specific gene expression, G1 arrest, mating projection, and cell fusion. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270839 [Multi-domain]  Cd Length: 336  Bit Score: 98.92  E-value: 1.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNEsedrhyamkvlskkkllkqygfprrppPRGSQATqggpAKQLLPLE------RVYQEI 200
Cdd:cd07849     6 RYQNLSYIGEGAYGMVCSAVHK---------------------------PTGQKVA----IKKISPFEhqtyclRTLREI 54
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 201 AILKKLDHVNVVKLIEVLDDPAEDNL---YLVFDLlrkgpvMEVPCDK-----PFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd07849    55 KILLRFKHENIIGILDIQRPPTFESFkdvYIVQEL------METDLYKliktqHLSNDHIQYFLYQILRGLKYIHSANVL 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFG---VSNQFEGNDAQLSSTAGTPAFMAPEaISDSGQSFSgKALDVWATGVTLYCFVYG 349
Cdd:cd07849   129 HRDLKPSNLLLNTNCDLKICDFGlarIADPEHDHTGFLTEYVATRWYRAPE-IMLNSKGYT-KAIDIWSVGCILAEMLSN 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 350 K--------------------CPFIDDYILTLHRKIKNEAVVFPEEPEVS---------EDLKDLILRMLDKNPETRIGV 400
Cdd:cd07849   207 RplfpgkdylhqlnlilgilgTPSQEDLNCIISLKARNYIKSLPFKPKVPwnklfpnadPKALDLLDKMLTFNPHKRITV 286
                         330       340       350
                  ....*....|....*....|....*....|
gi 1384865967 401 SDIKLHPWVTKH--------GEEPLPSEEE 422
Cdd:cd07849   287 EEALAHPYLEQYhdpsdepvAEEPFPFDME 316
STKc_Nek1 cd08218
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
127-403 1.30e-22

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek1 is associated with centrosomes throughout the cell cycle. It is involved in the formation of primary cilium and in the maintenance of centrosomes. It cycles through the nucleus and may be capable of relaying signals between the cilium and the nucleus. Nek1 is implicated in the development of polycystic kidney disease, which is characterized by benign polycystic tumors formed by abnormal overgrowth of renal epithelial cells. It appears also to be involved in DNA damage response, and may be important for both correct DNA damage checkpoint activation and DNA repair. Nek1 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270858 [Multi-domain]  Cd Length: 256  Bit Score: 96.80  E-value: 1.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKvlskkkllkQYGFPRRPPPRGSQATQggpakqllplervyqEIAILKKL 206
Cdd:cd08218     1 KYVRIKKIGEGSFGKALLVKSKEDGKQYVIK---------EINISKMSPKEREESRK---------------EVAVLSKM 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAedNLYLVFDLLRKGPVME-VPCDK--PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd08218    57 KHPNIVQYQESFEENG--NLYIVMDYCDGGDLYKrINAQRgvLFPEDQILDWFVQLCLALKHVHDRKILHRDIKSQNIFL 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 284 GDDGHVKIADFGVSNQFEgNDAQLSSTA-GTPAFMAPEAISDsgQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLH 362
Cdd:cd08218   135 TKDGIIKLGDFGIARVLN-STVELARTCiGTPYYLSPEICEN--KPYNNKS-DIWALGCVLYEMCTLKHAFEAGNMKNLV 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1384865967 363 RKIKNEAVVfPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd08218   211 LKIIRGSYP-PVPSRYSYDLRSLVSQLFKRNPRDRPSINSI 250
PK_TRB1 cd14023
Pseudokinase domain of Tribbles Homolog 1; The pseudokinase domain shows similarity to protein ...
243-408 1.36e-22

Pseudokinase domain of Tribbles Homolog 1; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. TRB1 interacts directly with the mitogen activated protein kinase (MAPK) kinase MKK4, an activator of JNK. It regulates vascular smooth muscle cell proliferation and chemotaxis through the JNK signaling pathway. It is found to be down-regulated in human acute myeloid leukaemia (AML) and may play a role in the pathogenesis of the disease. It has also been identified as a potential biomarker for antibody-mediated allograft failure. TRB1 is one of three Tribbles Homolog (TRB) proteins present in vertebrates that are encoded by three separate genes. TRB proteins interact with many proteins involved in signalling pathways. They play scaffold-like regulatory functions and affect many cellular processes such as mitosis, apoptosis, and gene expression. The TRB1 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270925 [Multi-domain]  Cd Length: 242  Bit Score: 96.66  E-value: 1.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 243 CDKPFPEEQARLYlRDIILGLEYLHCQKIVHRDIKPSNLLLGDD--GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPE 320
Cdd:cd14023    78 CKRLREEEAARLF-KQIVSAVAHCHQSAIVLGDLKLRKFVFSDEerTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPE 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 321 AISDSGqSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGV 400
Cdd:cd14023   157 ILNTTG-TYSGKSADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPD--HVSPKARCLIRSLLRREPSERLTA 233

                  ....*...
gi 1384865967 401 SDIKLHPW 408
Cdd:cd14023   234 PEILLHPW 241
STKc_Nek11 cd08222
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
199-409 1.51e-22

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek11 is involved, through direct phosphorylation, in regulating the degradation of Cdc25A (Cell Division Cycle 25 homolog A), which plays a role in cell cycle progression and in activating cyclin dependent kinases. Nek11 is activated by CHK1 (CHeckpoint Kinase 1) and may be involved in the G2/M checkpoint. Nek11 may also play a role in the S-phase checkpoint as well as in DNA replication and genotoxic stress responses. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270861 [Multi-domain]  Cd Length: 260  Bit Score: 96.72  E-value: 1.51e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-----VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:cd08222    52 EAKLLSKLDHPAIVKFHDSFVE--KESFCIVTEYCEGGDLDDkiseyKKSGTTIDENQILDWFIQLLLAVQYMHERRILH 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLgDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPF 353
Cdd:cd08222   130 RDLKAKNIFL-KNNVIKVGDFGISRILMGTSDLATTFTGTPYYMSPEVL--KHEGYNSKS-DIWSLGCILYEMCCLKHAF 205
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 354 IDDYILTLHRKIKNEAVvfPEEPEV-SEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd08222   206 DGQNLLSVMYKIVEGET--PSLPDKySKELNAIYSRMLNKDPALRPSAAEILKIPFI 260
STKc_EIF2AK4_GCN2_rpt2 cd14046
Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation ...
134-403 1.88e-22

Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GCN2 (or EIF2AK4) is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. Its kinase domain is activated via conformational changes as a result of the binding of uncharged tRNA to the HisRS-like domain. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270948 [Multi-domain]  Cd Length: 278  Bit Score: 97.05  E-value: 1.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKvlskkkllkqygfpRRPPPRGSQAtqggpakqllpLERVYQEIAILKKLDHVNVVK 213
Cdd:cd14046    14 LGKGAFGQVVKVRNKLDGRYYAIK--------------KIKLRSESKN-----------NSRILREVMLLSRLNHQHVVR 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 L----IEvlddpaEDNLYLVFDLLRKGPVMEVPCDKPFpEEQARL--YLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDG 287
Cdd:cd14046    69 YyqawIE------RANLYIQMEYCEKSTLRDLIDSGLF-QDTDRLwrLFRQILEGLAYIHSQGIIHRDLKPVNIFLDSNG 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 288 HVKIADFGV--SNQFE----------------GNDAQLSSTAGTPAFMAPEAISDSGQSFSGKAlDVWATGVTLYCFVYg 349
Cdd:cd14046   142 NVKIGDFGLatSNKLNvelatqdinkstsaalGSSGDLTGNVGTALYVAPEVQSGTKSTYNEKV-DMYSLGIIFFEMCY- 219
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 350 kcPFIDDY--ILTLhRKIKNEAVVFPEEPEVSEDLKD--LILRMLDKNPETRIGVSDI 403
Cdd:cd14046   220 --PFSTGMerVQIL-TALRSVSIEFPPDFDDNKHSKQakLIRWLLNHDPAKRPSAQEL 274
STKc_GRK5 cd05632
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs ...
199-408 2.09e-22

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK5 is widely expressed in many tissues. It associates with the membrane though an N-terminal PIP2 binding domain and also binds phospholipids via its C-terminus. GRK5 deficiency is associated with early Alzheimer's disease in humans and mouse models. GRK5 also plays a crucial role in the pathogenesis of sporadic Parkinson's disease. It participates in the regulation and desensitization of PDGFRbeta, a receptor tyrosine kinase involved in a variety of downstream cellular effects including cell growth, chemotaxis, apoptosis, and angiogenesis. GRK5 also regulates Toll-like receptor 4, which is involved in innate and adaptive immunity. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270780 [Multi-domain]  Cd Length: 313  Bit Score: 97.73  E-value: 2.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPV------MEVPcdkPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd05632    52 EKQILEKVNSQFVVNLAYAYE--TKDALCLVLTIMNGGDLkfhiynMGNP---GFEEERALFYAAEILCGLEDLHRENTV 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAISDSGQSFSGkalDVWATGVTLYCFVYGKCP 352
Cdd:cd05632   127 YRDLKPENILLDDYGHIRISDLGLAVKIPEGES-IRGRVGTVGYMAPEVLNNQRYTLSP---DYWGLGCLIYEMIEGQSP 202
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 353 FiddyiLTLHRKIKNEAV---VFPEE----PEVSEDLKDLILRMLDKNPETRI-----GVSDIKLHPW 408
Cdd:cd05632   203 F-----RGRKEKVKREEVdrrVLETEevysAKFSEEAKSICKMLLTKDPKQRLgcqeeGAGEVKRHPF 265
STKc_nPKC_epsilon cd05591
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze ...
223-408 2.14e-22

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-epsilon has been shown to behave as an oncoprotein. Its overexpression contributes to neoplastic transformation depending on the cell type. It contributes to oncogenesis by inducing disordered cell growth and inhibiting cell death. It also plays a role in tumor invasion and metastasis. PKC-epsilon has also been found to confer cardioprotection against ischemia and reperfusion-mediated damage. Other cellular functions include the regulation of gene expression, cell adhesion, and cell motility. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-epsilon subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270743 [Multi-domain]  Cd Length: 321  Bit Score: 97.95  E-value: 2.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
Cdd:cd05591    68 KDRLFFVMEYVNGGDLMfQIQRARKFDEPRARFYAAEVTLALMFLHRHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGI 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPeePEVSED 381
Cdd:cd05591   148 LNGKTTTTFCGTPDYIAPEILQELEYGPS---VDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYP--VWLSKE 222
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1384865967 382 LKDLILRMLDKNPETRIGV-------SDIKLHPW 408
Cdd:cd05591   223 AVSILKAFMTKNPAKRLGCvasqggeDAIRQHPF 256
STKc_Nek8 cd08220
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
134-407 2.16e-22

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. A double point mutation in Nek8 causes cystic kidney disease in mice that genetically resembles human autosomal recessive polycystic kidney disease (ARPKD). Nek8 is also associated with a rare form of juvenile renal cystic disease, nephronophthisis type 9. It has been suggested that a defect in the ciliary localization of Nek8 contributes to the development of cysts manifested by these diseases. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270859 [Multi-domain]  Cd Length: 256  Bit Score: 96.34  E-value: 2.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAynesedrhyamkvlskkkllkqygfpRRPPPRGSQATQGGPAKQLLPLER--VYQEIAILKKLDHVNV 211
Cdd:cd08220     8 VGRGAYGTVYLC--------------------------RRKDDNKLVIIKQIPVEQMTKEERqaALNEVKVLSMLHHPNI 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 212 VKLIE-VLDDPAednLYLVFDLLRKGPVMEV---PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLgDDG 287
Cdd:cd08220    62 IEYYEsFLEDKA---LMIVMEYAPGGTLFEYiqqRKGSLLSEEEILHFFVQILLALHHVHSKQILHRDLKTQNILL-NKK 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 288 H--VKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLHRKI 365
Cdd:cd08220   138 RtvVKIGDFGIS-KILSSKSKAYTVVGTPCYISPELC--EGKPYNQKS-DIWALGCVLYELASLKRAFEAANLPALVLKI 213
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1384865967 366 KnEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd08220   214 M-RGTFAPISDRYSEELRHLILSMLHLDPNKRPTLSEIMAQP 254
STKc_MEKK3 cd06651
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
134-390 2.31e-22

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK3 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. In addition, MEKK3 is involved in interleukin-1 receptor and Toll-like receptor 4 signaling. It is also a specific regulator of the proinflammatory cytokines IL-6 and GM-CSF in some immune cells. MEKK3 also regulates calcineurin, which plays a critical role in T cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. The MEKK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270817 [Multi-domain]  Cd Length: 271  Bit Score: 96.69  E-value: 2.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAmkvlskkklLKQYGFPRRPPPrgsqatqggPAKQLLPLErvyQEIAILKKLDHVNVVK 213
Cdd:cd06651    15 LGQGAFGRVYLCYDVDTGRELA---------AKQVQFDPESPE---------TSKEVSALE---CEIQLLKNLQHERIVQ 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDPAEDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd06651    74 YYGCLRDRAEKTLTIFMEYMPGGSVKdQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLG 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGVSNQFEG---NDAQLSSTAGTPAFMAPEAISDSGQsfsGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEA 369
Cdd:cd06651   154 DFGASKRLQTicmSGTGIRSVTGTPYWMSPEVISGEGY---GRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQP 230
                         250       260
                  ....*....|....*....|.
gi 1384865967 370 VVFPEEPEVSEDLKDLILRML 390
Cdd:cd06651   231 TNPQLPSHISEHARDFLGCIF 251
PKc_MKK3_6 cd06617
Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase ...
259-415 2.82e-22

Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK3 and MKK6 are dual-specificity PKs that phosphorylate and activate their downstream target, p38 MAPK, on specific threonine and tyrosine residues. MKK3/6 play roles in the regulation of cell cycle progression, cytokine- and stress-induced apoptosis, oncogenic transformation, and adult tissue regeneration. In addition, MKK6 plays a critical role in osteoclast survival in inflammatory disease while MKK3 is associated with tumor invasion, progression, and poor patient survival in glioma. The MKK3/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173729 [Multi-domain]  Cd Length: 283  Bit Score: 96.72  E-value: 2.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 259 IILGLEYLHCQ-KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQlSSTAGTPAFMAPEAISDSG--QSFSGKAlD 335
Cdd:cd06617   112 IVKALEYLHSKlSVIHRDVKPSNVLINRNGQVKLCDFGISGYLVDSVAK-TIDAGCKPYMAPERINPELnqKGYDVKS-D 189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 336 VWATGVTLYCFVYGKCPFidDYILTLHRKIKNeaVV------FPEEPeVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06617   190 VWSLGITMIELATGRFPY--DSWKTPFQQLKQ--VVeepspqLPAEK-FSPEFQDFVNKCLKKNYKERPNYPELLQHPFF 264

                  ....*.
gi 1384865967 410 TKHGEE 415
Cdd:cd06617   265 ELHLSK 270
STKc_MLK1 cd14145
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the ...
193-353 3.08e-22

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK1 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K9. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Little is known about the specific function of MLK1. It is capable of activating the c-Jun N-terminal kinase pathway. Mice lacking both MLK1 and MLK2 are viable, fertile, and have normal life spans. There could be redundancy in the function of MLKs. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271047 [Multi-domain]  Cd Length: 270  Bit Score: 96.26  E-value: 3.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEV-LDDPaedNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd14145    49 IENVRQEAKLFAMLKHPNIIALRGVcLKEP---NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHCEAI 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 V---HRDIKPSNLLL------GD--DGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAISDSgqSFSgKALDVWATG 340
Cdd:cd14145   126 VpviHRDLKSSNILIlekvenGDlsNKILKITDFGLAREWHRTTKM--SAAGTYAWMAPEVIRSS--MFS-KGSDVWSYG 200
                         170
                  ....*....|...
gi 1384865967 341 VTLYCFVYGKCPF 353
Cdd:cd14145   201 VLLWELLTGEVPF 213
STKc_Kalirin_C cd14115
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
187-408 3.50e-22

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kalirin, also called Duo or Duet, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. As a GEF, it activates Rac1, RhoA, and RhoG. It is highly expressed in neurons and is required for spine formation. The kalirin gene produces at least 10 isoforms from alternative promoter use and splicing. Of the major isoforms (Kalirin-7, -9, and -12), only kalirin-12 contains the C-terminal kinase domain. Kalirin-12 is highly expressed during embryonic development and it plays an important role in axon outgrowth. The Kalirin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271017 [Multi-domain]  Cd Length: 248  Bit Score: 95.41  E-value: 3.50e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 187 AKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAedNLYLVFDLLRKGPVME--VPCDKpFPEEQARLYLRDIILGLE 264
Cdd:cd14115    27 SKKMKKKEQAAHEAALLQHLQHPQYITLHDTYESPT--SYILVLELMDDGRLLDylMNHDE-LMEEKVAFYIRDIMEALQ 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 265 YLHCQKIVHRDIKPSNLLLG---DDGHVKIADFGVSNQFEGNdAQLSSTAGTPAFMAPEAISDSGQSFsgkALDVWATGV 341
Cdd:cd14115   104 YLHNCRVAHLDIKPENLLIDlriPVPRVKLIDLEDAVQISGH-RHVHHLLGNPEFAAPEVIQGTPVSL---ATDIWSIGV 179
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 342 TLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14115   180 LTYVMLSGVSPFLDESKEETCINVCRVDFSFPDEyfGDVSQAARDFINVILQEDPRRRPTAATCLQHPW 248
STKc_CaMK_like cd14088
Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to ...
199-409 3.93e-22

Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to Calcium/calmodulin-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized STKs with similarity to CaMKs, which are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. This uncharacterized subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270990 [Multi-domain]  Cd Length: 265  Bit Score: 95.86  E-value: 3.93e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPAEdnlYLVFDLLRKG-PVMEVPCDKPF-PEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd14088    49 EINILKMVKHPNILQLVDVFETRKE---YFIFLELATGrEVFDWILDQGYySERDTSNVIRQVLEAVAYLHSLKIVHRNL 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGD---DGHVKIADFGVSNQFEGndaQLSSTAGTPAFMAPEAIsdsGQSFSGKALDVWATGVTLYCFVYGKCPF 353
Cdd:cd14088   126 KLENLVYYNrlkNSKIVISDFHLAKLENG---LIKEPCGTPEYLAPEVV---GRQRYGRPVDCWAIGVIMYILLSGNPPF 199
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 354 ID-----DY---ILTLHRKIKNEAVVF--PEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14088   200 YDeaeedDYenhDKNLFRKILAGDYEFdsPYWDDISQAAKDLVTRLMEVEQDQRITAEEAISHEWI 265
STKc_IRE1 cd13982
Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze ...
198-407 6.17e-22

Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), is an ER-localized type I transmembrane protein with kinase and endoribonuclease domains in the cytoplasmic side. It acts as an ER stress sensor and is the oldest and most conserved component of the unfolded protein response (UPR) in eukaryotes. The UPR is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. During ER stress, IRE1 dimerizes and forms oligomers, allowing the kinase domain to undergo trans-autophosphorylation. This leads to a conformational change that stimulates its endoribonuclease activity and results in the cleavage of its mRNA substrate, HAC1 in yeast and XBP1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. Mammals contain two IRE1 proteins, IRE1alpha (or ERN1) and IRE1beta (or ERN2). The Ire1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270884 [Multi-domain]  Cd Length: 269  Bit Score: 95.42  E-value: 6.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLD-HVNVVKLIEVLDDpaEDNLYLV--------FDLLRKGPVMEvpcDKPFPEEQARLYLRDIILGLEYLHC 268
Cdd:cd13982    43 REVQLLRESDeHPNVIRYFCTEKD--RQFLYIAlelcaaslQDLVESPRESK---LFLRPGLEPVRLLRQIASGLAHLHS 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 269 QKIVHRDIKPSNLLL-----GDDGHVKIADFGVSNQFEGNDAQLSST---AGTPAFMAPEAISDSGQSFSGKALDVWATG 340
Cdd:cd13982   118 LNIVHRDLKPQNILIstpnaHGNVRAMISDFGLCKKLDVGRSSFSRRsgvAGTSGWIAPEMLSGSTKRRQTRAVDIFSLG 197
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 341 -VTLYCFVYGKCPFIDDYIltlhRK---IKNEAVVFPEEPEVSE--DLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd13982   198 cVFYYVLSGGSHPFGDKLE----REaniLKGKYSLDKLLSLGEHgpEAQDLIERMIDFDPEKRPSAEEVLNHP 266
STKc_TEY_MAPK cd07858
Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; ...
134-425 8.07e-22

Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TEY subtype of plant MAPKs and is further subdivided into three groups (A, B, and C). Group A is represented by AtMPK3, AtMPK6, Nicotiana tabacum BTF4 (NtNTF4), among others. They are mostly involved in environmental and hormonal responses. AtMPK3 and AtMPK6 are also key regulators for stomatal development and patterning. Group B is represented by AtMPK4, AtMPK13, and NtNTF6, among others. They may be involved in both cell division and environmental stress response. AtMPK4 also participates in regulating innate immunity. Group C is represented by AtMPK1, AtMPK2, NtNTF3, Oryza sativa MAPK4 (OsMAPK4), among others. They may also be involved in stress responses. AtMPK1 and AtMPK2 are activated following mechanical injury and in the presence of stress chemicals such as jasmonic acid, hydrogen peroxide and abscisic acid. OsMAPK4 is also called OsMSRMK3 for Multiple Stress-Responsive MAPK3. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20. The TEY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143363 [Multi-domain]  Cd Length: 337  Bit Score: 96.29  E-value: 8.07e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 134 IGKGAYGVVRLAYNESEDRHYAMKVLSKKkllkqygFPRRPPPRgsqatqggpakqllpleRVYQEIAILKKLDHVNVVK 213
Cdd:cd07858    13 IGRGAYGIVCSAKNSETNEKVAIKKIANA-------FDNRIDAK-----------------RTLREIKLLRHLDHENVIA 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 214 LIEVLDDPAEDN---LYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVK 290
Cdd:cd07858    69 IKDIMPPPHREAfndVYIVYELMDTDLHQIIRSSQTLSDDHCQYFLYQLLRGLKYIHSANVLHRDLKPSNLLLNANCDLK 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 291 IADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSgqSFSGKALDVWATGVTLYCFVYGKCPFI-DDYI--LTL------ 361
Cdd:cd07858   149 ICDFGLARTTSEKGDFMTEYVVTRWYRAPELLLNC--SEYTTAIDVWSVGCIFAELLGRKPLFPgKDYVhqLKLitellg 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 362 ---------------HRKIKN----EAVVFPEE-PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEeplPSEE 421
Cdd:cd07858   227 spseedlgfirnekaRRYIRSlpytPRQSFARLfPHANPLAIDLLEKMLVFDPSKRITVEEALAHPYLASLHD---PSDE 303

                  ....
gi 1384865967 422 EHCS 425
Cdd:cd07858   304 PVCQ 307
STKc_Nek4 cd08223
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
127-409 9.66e-22

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek4 is highly abundant in the testis. Its specific function is unknown. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. Nek4 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270862 [Multi-domain]  Cd Length: 257  Bit Score: 94.43  E-value: 9.66e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfpRRPPPRGSQATQggpakqllplervyQEIAILKKL 206
Cdd:cd08223     1 EYQFLRVIGKGSYGEVWLVRHKRDRKQYVIKKLNL----------KNASKRERKAAE--------------QEAKLLSKL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDpaEDN-LYLVFDLLRKGPV---MEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:cd08223    57 KHPNIVSYKESFEG--EDGfLYIVMGFCEGGDLytrLKEQKGVLLEERQVVEWFVQIAMALQYMHERNILHRDLKTQNIF 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 LGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDsgQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLH 362
Cdd:cd08223   135 LTKSNIIKVGDLGIARVLESSSDMATTLIGTPYYMSPELFSN--KPYNHKS-DVWALGCCVYEMATLKHAFNAKDMNSLV 211
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 363 RKIKNEAVvfPEEP-EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd08223   212 YKILEGKL--PPMPkQYSPELGELIKAMLHQDPEKRPSVKRILRQPYI 257
PKc_MKK7 cd06618
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
239-412 1.00e-21

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK7 is a dual-specificity PK that phosphorylates and activates its downstream target, c-Jun N-terminal kinase (JNK), on specific threonine and tyrosine residues. Although MKK7 is capable of dual phosphorylation, it prefers to phosphorylate the threonine residue of JNK. Thus, optimal activation of JNK requires both MKK4 and MKK7. MKK7 is primarily activated by cytokines. MKK7 is essential for liver formation during embryogenesis. It plays roles in G2/M cell cycle arrest and cell growth. In addition, it is involved in the control of programmed cell death, which is crucial in oncogenesis, cancer chemoresistance, and antagonism to TNFalpha-induced killing, through its inhibition by Gadd45beta and the subsequent suppression of the JNK cascade. The MKK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270791 [Multi-domain]  Cd Length: 295  Bit Score: 95.13  E-value: 1.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 239 MEVPCDK-------PFPEEQARLYLRDIILGLEYL-HCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQlSST 310
Cdd:cd06618    96 MSTCLDKllkriqgPIPEDILGKMTVSIVKALHYLkEKHGVIHRDVKPSNILLDESGNVKLCDFGISGRLVDSKAK-TRS 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 311 AGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPF--IDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILR 388
Cdd:cd06618   175 AGCAAYMAPERIDPPDNPKYDIRADVWSLGISLVELATGQFPYrnCKTEFEVLTKILNEEPPSLPPNEGFSPDFCSFVDL 254
                         170       180
                  ....*....|....*....|....
gi 1384865967 389 MLDKNPETRIGVSDIKLHPWVTKH 412
Cdd:cd06618   255 CLTKDHRYRPKYRELLQHPFIRRY 278
PTKc_Jak_rpt2 cd05038
Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily ...
198-349 1.16e-21

Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are PTKs, catalyzing the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jaks are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270634 [Multi-domain]  Cd Length: 284  Bit Score: 94.76  E-value: 1.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVpcdkpFPEEQAR-------LYLRDIILGLEYLHCQK 270
Cdd:cd05038    55 REIEILRTLDHEYIVKYKGVCESPGRRSLRLIMEYLPSGSLRDY-----LQRHRDQidlkrllLFASQICKGMEYLGSQR 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTA--GTPAF-MAPEAISDSGQSFSGkalDVWATGVTLY-CF 346
Cdd:cd05038   130 YIHRDLAARNILVESEDLVKISDFGLAKVLPEDKEYYYVKEpgESPIFwYAPECLRESRFSSAS---DVWSFGVTLYeLF 206

                  ...
gi 1384865967 347 VYG 349
Cdd:cd05038   207 TYG 209
STKc_LATS1 cd05625
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1; STKs catalyze the ...
196-408 1.20e-21

Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS1 functions as a tumor suppressor and is implicated in cell cycle regulation. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. Promoter methylation, loss of heterozygosity, and missense mutations targeting the LATS1 gene have also been found in human sarcomas and ovarian cancers. In addition, decreased expression of LATS1 is associated with an aggressive phenotype and poor prognosis. LATS1 induces G2 arrest and promotes cytokinesis. It may be a component of the mitotic exit network in higher eukaryotes. The LATS1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270775 [Multi-domain]  Cd Length: 382  Bit Score: 96.65  E-value: 1.20e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 196 VYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd05625    48 VKAERDILAEADNEWVVRLYYSFQD--KDNLYFVMDYIPGGDMMSLLIRMGvFPEDLARFYIAELTCAVESVHKMGFIHR 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQF------------------------EGNDAQ-----------------------L 307
Cdd:cd05625   126 DIKPDNILIDRDGHIKLTDFGLCTGFrwthdskyyqsgdhlrqdsmdfsnEWGDPEncrcgdrlkplerraarqhqrclA 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 308 SSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKN--EAVVFPEEPEVSEDLKDL 385
Cdd:cd05625   206 HSLVGTPNYIAPEVLLRTGYT---QLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINwqTSLHIPPQAKLSPEASDL 282
                         250       260
                  ....*....|....*....|....*.
gi 1384865967 386 ILRMLdKNPETRI---GVSDIKLHPW 408
Cdd:cd05625   283 IIKLC-RGPEDRLgknGADEIKAHPF 307
PK_TRB2 cd14022
Pseudokinase domain of Tribbles Homolog 2; The pseudokinase domain shows similarity to protein ...
243-408 1.49e-21

Pseudokinase domain of Tribbles Homolog 2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. TRB2 binds and negatively regulates the mitogen activated protein kinase (MAPK) kinases, MKK7 and MEK1, which are activators of the MAPKs, ERK and JNK. It controls the activation of inflammatory monocytes, which is essential in innate immune responses and the pathogenesis of inflammatory diseases such as atherosclerosis. TRB2 expression is down-regulated in human acute myeloid leukaemia (AML), which may lead to enhanced cell survival and pathogenesis of the disease. TRB2 is one of three Tribbles Homolog (TRB) proteins present in vertebrates that are encoded by three separate genes. TRB proteins interact with many proteins involved in signalling pathways. They play scaffold-like regulatory functions and affect many cellular processes such as mitosis, apoptosis, and gene expression. The TRB2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270924 [Multi-domain]  Cd Length: 242  Bit Score: 93.56  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 243 CDKPFPEEQARLYLRdIILGLEYLHCQKIVHRDIKPSNLLL--GDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPE 320
Cdd:cd14022    78 CKKLREEEAARLFYQ-IASAVAHCHDGGLVLRDLKLRKFVFkdEERTRVKLESLEDAYILRGHDDSLSDKHGCPAYVSPE 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 321 AISDSGqSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGV 400
Cdd:cd14022   157 ILNTSG-SYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPE--TLSPKAKCLIRSILRREPSERLTS 233

                  ....*...
gi 1384865967 401 SDIKLHPW 408
Cdd:cd14022   234 QEILDHPW 241
STKc_Sty1_Hog1 cd07856
Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases ...
194-420 1.91e-21

Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs Sty1 from Schizosaccharomyces pombe, Hog1 from Saccharomyces cerevisiae, and similar proteins. Sty1 and Hog1 are stress-activated MAPKs that partipate in transcriptional regulation in response to stress. Sty1 is activated in response to oxidative stress, osmotic stress, and UV radiation. It is regulated by the MAP2K Wis1, which is activated by the MAP3Ks Wis4 and Win1, which receive signals of the stress condition from membrane-spanning histidine kinases Mak1-3. Activated Sty1 stabilizes the Atf1 transcription factor and induces transcription of Atf1-dependent genes of the core environmetal stress response. Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription. The HOG pathway is mediated by two transmembrane osmosensors, Sln1 and Sho1. MAPKs are important mediators of cellular responses to extracellular signals. The Sty1/Hog1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270843 [Multi-domain]  Cd Length: 328  Bit Score: 95.33  E-value: 1.91e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEDnLYLVFDLLRKGpVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:cd07856    54 KRTYRELKLLKHLRHENIISLSDIFISPLED-IYFVTELLGTD-LHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVIH 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLGDDGHVKIADFGVSNQfegNDAQLSSTAGTPAFMAPEaISDSGQSFSgKALDVWATGVTLYCFVYGKCPF 353
Cdd:cd07856   132 RDLKPSNILVNENCDLKICDFGLARI---QDPQMTGYVSTRYYRAPE-IMLTWQKYD-VEVDIWSAGCIFAEMLEGKPLF 206
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 354 -------------------IDDYILTLHRK---------IKNEAVVFPEE-PEVSEDLKDLILRMLDKNPETRIGVSDIK 404
Cdd:cd07856   207 pgkdhvnqfsiitellgtpPDDVINTICSEntlrfvqslPKRERVPFSEKfKNADPDAIDLLEKMLVFDPKKRISAAEAL 286
                         250
                  ....*....|....*....
gi 1384865967 405 LHPWVTKH---GEEPLPSE 420
Cdd:cd07856   287 AHPYLAPYhdpTDEPVADE 305
STKc_cPKC_alpha cd05615
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs ...
117-421 2.69e-21

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-alpha is expressed in many tissues and is associated with cell proliferation, apoptosis, and cell motility. It plays a role in the signaling of the growth factors PDGF, VEGF, EGF, and FGF. Abnormal levels of PKC-alpha have been detected in many transformed cell lines and several human tumors. In addition, PKC-alpha is required for HER2 dependent breast cancer invasion. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. The cPKC-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270766 [Multi-domain]  Cd Length: 341  Bit Score: 95.06  E-value: 2.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 117 SDTEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQATQGGPAKqLLPLERV 196
Cdd:cd05615     1 SNNLDRVRLTDFNFLMVLGKGSFGKVMLAERKGSDELYAIKILKKDVVIQDDDVECTMVEKRVLALQDKPPF-LTQLHSC 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 197 YQEIailkkldhvnvvklievlddpaeDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd05615    80 FQTV-----------------------DRLYFVMEYVNGGDLMyHIQQVGKFKEPQAVFYAAEISVGLFFLHKKGIIYRD 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFsGKALDVWATGVTLYCFVYGKCPFID 355
Cdd:cd05615   137 LKLDNVMLDSEGHIKIADFGMCKEHMVEGVTTRTFCGTPDYIAPEII--AYQPY-GRSVDWWAYGVLLYEMLAGQPPFDG 213
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 356 DYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVS-----DIKLHPWVTKHGEEPLPSEE 421
Cdd:cd05615   214 EDEDELFQSIMEHNVSYPK--SLSKEAVSICKGLMTKHPAKRLGCGpegerDIREHAFFRRIDWDKLENRE 282
STKc_Nek9 cd08221
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
199-407 2.72e-21

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek9, also called Nercc1, is primarily a cytoplasmic protein but can also localize in the nucleus. It is involved in modulating chromosome alignment and splitting during mitosis. It interacts with the gamma-tubulin ring complex and the Ran GTPase, and is implicated in microtubule organization. Nek9 associates with FACT (FAcilitates Chromatin Transcription) and modulates interphase progression. It also interacts with Nek6, and Nek7, during mitosis, resulting in their activation. Nek9 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270860 [Multi-domain]  Cd Length: 256  Bit Score: 93.26  E-value: 2.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME---VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd08221    49 EIDILSLLNHDNIITYYNHFLD--GESLFIEMEYCNGGNLHDkiaQQKNQLFPEEVVLWYLYQIVSAVSHIHKAGILHRD 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFID 355
Cdd:cd08221   127 IKTLNIFLTKADLVKLGDFGISKVLDSESSMAESIVGTPYYMSPELV--QGVKYNFKS-DIWAVGCVLYELLTLKRTFDA 203
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 356 DYILTLHRKI-KNEAVVfpEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd08221   204 TNPLRLAVKIvQGEYED--IDEQYSEEIIQLVHDCLHQDPEDRPTAEELLERP 254
STKc_MAP3K12_13 cd14059
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase ...
199-355 2.91e-21

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K12 is also called MAPK upstream kinase (MUK), dual leucine zipper-bearing kinase (DLK) or leucine-zipper protein kinase (ZPK). It is involved in the c-Jun N-terminal kinase (JNK) pathway that directly regulates axonal regulation through the phosphorylation of microtubule-associated protein 1B (MAP1B). It also regulates the differentiation of many cell types including adipocytes and may play a role in adipogenesis. MAP3K13, also called leucine zipper-bearing kinase (LZK), directly phosphorylates and activates MKK7, which in turn activates the JNK pathway. It also activates NF-kB through IKK activation and this activity is enhanced by antioxidant protein-1 (AOP-1). MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAP2Ks (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K12/13 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270961 [Multi-domain]  Cd Length: 237  Bit Score: 92.56  E-value: 2.91e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLddpAEDNLY-LVFDLLRKGPVMEVPCD-KPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd14059    31 DIKHLRKLNHPNIIKFKGVC---TQAPCYcILMEYCPYGQLYEVLRAgREITPSLLVDWSKQIASGMNYLHLHKIIHRDL 107
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLsSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCPFID 355
Cdd:cd14059   108 KSPNVLVTYNDVLKISDFGTSKELSEKSTKM-SFAGTVAWMAPEVIRNEPCSEK---VDIWSFGVVLWELLTGEIPYKD 182
STKc_aPKC_zeta cd05617
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze ...
223-406 2.93e-21

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC-zeta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270768 [Multi-domain]  Cd Length: 357  Bit Score: 95.09  E-value: 2.93e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
Cdd:cd05617    88 TSRLFLVIEYVNGGDLMfHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGL 167
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCPFiddYILTLHRKIKNEAVVFP---EEP-- 376
Cdd:cd05617   168 GPGDTTSTFCGTPNYIAPEILRGEEYGFS---VDWWALGVLMFEMMAGRSPF---DIITDNPDMNTEDYLFQvilEKPir 241
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1384865967 377 ---EVSEDLKDLILRMLDKNPETRIGV------SDIKLH 406
Cdd:cd05617   242 iprFLSVKASHVLKGFLNKDPKERLGCqpqtgfSDIKSH 280
STKc_MASTL cd05610
Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like ...
224-407 3.27e-21

Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MASTL kinases in this group carry only a catalytic domain, which contains a long insertion relative to MAST kinases. MASTL, also called greatwall kinase (Gwl), is involved in the regulation of mitotic entry, which is controlled by the coordinated activities of protein kinases and opposing protein phosphatases (PPs). The cyclin B/CDK1 complex induces entry into M-phase while PP2A-B55 shows anti-mitotic activity. MASTL/Gwl is activated downstream of cyclin B/CDK1 and indirectly inhibits PP2A-B55 by phosphorylating the small protein alpha-endosulfine (Ensa) or the cAMP-regulated phosphoprotein 19 (Arpp19), resulting in M-phase progression. Gwl kinase may also play roles in mRNA stabilization and DNA checkpoint recovery. The human MASTL gene has also been named FLJ14813; a missense mutation in FLJ14813 is associated with autosomal dominant thrombocytopenia. The MASTL kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270761 [Multi-domain]  Cd Length: 349  Bit Score: 94.95  E-value: 3.27e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 224 DNLYLVFDLLRKGPVMEV-PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS----- 297
Cdd:cd05610    77 NNVYLVMEYLIGGDVKSLlHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSkvtln 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 298 ------------------NQFEGNDAQLSSTA------------------------------GTPAFMAPEAISDSGQsf 329
Cdd:cd05610   157 relnmmdilttpsmakpkNDYSRTPGQVLSLIsslgfntptpyrtpksvrrgaarvegerilGTPDYLAPELLLGKPH-- 234
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 330 sGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPE-EPEVSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd05610   235 -GPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILNRDIPWPEgEEELSVNAQNAIEILLTMDPTKRAGLKELKQHP 312
STKc_MPK1 cd07857
Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; ...
128-425 4.12e-21

Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs MPK1 from Saccharomyces cerevisiae, Pmk1 from Schizosaccharomyces pombe, and similar proteins. MPK1 (also called Slt2) and Pmk1 (also called Spm1) are stress-activated MAPKs that regulate the cell wall integrity pathway, and are therefore important in the maintainance of cell shape, cell wall construction, morphogenesis, and ion homeostasis. MPK1 is activated in response to cell wall stress including heat stimulation, osmotic shock, UV irradiation, and any agents that interfere with cell wall biogenesis such as chitin antagonists, caffeine, or zymolase. MPK1 is regulated by the MAP2Ks Mkk1/2, which are regulated by the MAP3K Bck1. Pmk1 is also activated by multiple stresses including elevated temperatures, hyper- or hypotonic stress, glucose deprivation, exposure to cell-wall damaging compounds, and oxidative stress. It is regulated by the MAP2K Pek1, which is regulated by the MAP3K Mkh1. MAPKs are important mediators of cellular responses to extracellular signals. The MPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173750 [Multi-domain]  Cd Length: 332  Bit Score: 94.39  E-value: 4.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYN--ESEDRHYAMKVLSKKkllkqygFprrppprgsqatqggpAKQLLpLERVYQEIAILKK 205
Cdd:cd07857     2 YELIKELGQGAYGIVCSARNaeTSEEETVAIKKITNV-------F----------------SKKIL-AKRALRELKLLRH 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 L-DHVNVVKLI--EVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:cd07857    58 FrGHKNITCLYdmDIVFPGNFNELYLYEELMEADLHQIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLL 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 LGDDGHVKIADFGVS-----NQFEgNDAQLSSTAGTPAFMAPEaISDSGQSFSgKALDVWATGVTLYCFVYGKcPFID-- 355
Cdd:cd07857   138 VNADCELKICDFGLArgfseNPGE-NAGFMTEYVATRWYRAPE-IMLSFQSYT-KAIDVWSVGCILAELLGRK-PVFKgk 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 356 DYI----LTLH----------RKIKNEAVV-----FPEEPEV---------SEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd07857   214 DYVdqlnQILQvlgtpdeetlSRIGSPKAQnyirsLPNIPKKpfesifpnaNPLALDLLEKLLAFDPTKRISVEEALEHP 293
                         330
                  ....*....|....*...
gi 1384865967 408 WVTKHGEeplPSEEEHCS 425
Cdd:cd07857   294 YLAIWHD---PDDEPVCQ 308
STKc_CDK9 cd07865
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs ...
122-340 4.47e-21

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK9, together with a cyclin partner (cyclin T1, T2a, T2b, or K), is the main component of distinct positive transcription elongation factors (P-TEFb), which function as Ser2 C-terminal domain kinases of RNA polymerase II. P-TEFb participates in multiple steps of gene expression including transcription elongation, mRNA synthesis, processing, export, and translation. It also plays a role in mediating cytokine induced transcription networks such as IL6-induced STAT3 signaling. In addition, the CDK9/cyclin T2a complex promotes muscle differentiation and enhances the function of some myogenic regulatory factors. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270848 [Multi-domain]  Cd Length: 310  Bit Score: 93.59  E-value: 4.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 122 CVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLlplervyQEIA 201
Cdd:cd07865     8 CDEVSKYEKLAKIGQGTFGEVFKARHRKTGQIVALKKV-----------------LMENEKEGFPITAL-------REIK 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 202 ILKKLDHVNVVKLIEVLDDPA------EDNLYLVFD--------LLRKGPVmevpcdkPFPEEQARLYLRDIILGLEYLH 267
Cdd:cd07865    64 ILQLLKHENVVNLIEICRTKAtpynryKGSIYLVFEfcehdlagLLSNKNV-------KFTLSEIKKVMKMLLNGLYYIH 136
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 268 CQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF----EGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATG 340
Cdd:cd07865   137 RNKILHRDMKAANILITKDGVLKLADFGLARAFslakNSQPNRYTNRVVTLWYRPPELL--LGERDYGPPIDMWGAG 211
STKc_RIP cd13978
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze ...
194-397 5.13e-21

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP kinases serve as essential sensors of cellular stress. They are involved in regulating NF-kappaB and MAPK signaling, and are implicated in mediating cellular processes such as apoptosis, necroptosis, differentiation, and survival. RIP kinases contain a homologous N-terminal kinase domain and varying C-terminal domains. Higher vertebrates contain multiple RIP kinases, with mammals harboring at least five members. RIP1 and RIP2 harbor C-terminal domains from the Death domain (DD) superfamily while RIP4 contains ankyrin (ANK) repeats. RIP3 contain a RIP homotypic interaction motif (RHIM) that facilitates binding to RIP1. RIP1 and RIP3 are important in apoptosis and necroptosis, while RIP2 and RIP4 play roles in keratinocyte differentiation and inflammatory immune responses. The RIP subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270880 [Multi-domain]  Cd Length: 263  Bit Score: 92.52  E-value: 5.13e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEV----PCDKPFPeeqarLYLR---DIILGLEYL 266
Cdd:cd13978    37 KALLKEAEKMERARHSYVLPLLGVCVERRS--LGLVMEYMENGSLKSLlereIQDVPWS-----LRFRiihEIALGMNFL 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 267 HCQK--IVHRDIKPSNLLLGDDGHVKIADFGVS-------NQFEGNDAQlsSTAGTPAFMAPEAISDSGQSFSGKAlDVW 337
Cdd:cd13978   110 HNMDppLLHHDLKPENILLDNHFHVKISDFGLSklgmksiSANRRRGTE--NLGGTPIYMAPEAFDDFNKKPTSKS-DVY 186
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 338 ATGVTLYCFVYGKCPFiDDYILTLHRKIKNEAVVFPEEPEVSED--------LKDLILRMLDKNPETR 397
Cdd:cd13978   187 SFAIVIWAVLTRKEPF-ENAINPLLIMQIVSKGDRPSLDDIGRLkqienvqeLISLMIRCWDGNPDAR 253
STKc_CDK12 cd07864
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs ...
125-409 5.29e-21

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an RS domain, which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2, and plays roles in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270847 [Multi-domain]  Cd Length: 302  Bit Score: 93.33  E-value: 5.29e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLlplervyQEIAILK 204
Cdd:cd07864     6 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKV-----------------RLDNEKEGFPITAI-------REIKILR 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDDPAE--------DNLYLVFD--------LLRKGPVmevpcdkPFPEEQARLYLRDIILGLEYLHC 268
Cdd:cd07864    62 QLNHRSVVNLKEIVTDKQDaldfkkdkGAFYLVFEymdhdlmgLLESGLV-------HFSEDHIKSFMKQLLEGLNYCHK 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 269 QKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQL-SSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFV 347
Cdd:cd07864   135 KNFLHRDIKCSNILLNNKGQIKLADFGLARLYNSEESRPyTNKVITLWYRPPELL--LGEERYGPAIDVWSCGCILGELF 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 348 YGK----------------------CPFIDDYILTL------------HRKIKNEavvFPEEPEVSEDLKDlilRMLDKN 393
Cdd:cd07864   213 TKKpifqanqelaqlelisrlcgspCPAVWPDVIKLpyfntmkpkkqyRRRLREE---FSFIPTPALDLLD---HMLTLD 286
                         330
                  ....*....|....*.
gi 1384865967 394 PETRIGVSDIKLHPWV 409
Cdd:cd07864   287 PSKRCTAEQALNSPWL 302
STKc_GRK7 cd05607
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; ...
255-399 6.05e-21

Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK7 (also called iodopsin kinase) belongs to the visual group of GRKs. It is primarily found in the retina and plays a role in the regulation of opsin light receptors. GRK7 is located in retinal cone outer segments and plays an important role in regulating photoresponse of the cones. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270758 [Multi-domain]  Cd Length: 286  Bit Score: 93.05  E-value: 6.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 255 YLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAISDSGQSFSgkaL 334
Cdd:cd05607   109 YSAQITCGILHLHSLKIVYRDMKPENVLLDDNGNCRLSDLGLAVEVKEGKP-ITQRAGTNGYMAPEILKEESYSYP---V 184
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 335 DVWATGVTLYCFVYGKCPFIDDYILT----LHRKIKNEAVVFpEEPEVSEDLKDLILRMLDKNPETRIG 399
Cdd:cd05607   185 DWFAMGCSIYEMVAGRTPFRDHKEKVskeeLKRRTLEDEVKF-EHQNFTEEAKDICRLFLAKKPENRLG 252
STKc_MAPK4_6 cd07854
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also ...
198-408 9.02e-21

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK4 (also called ERK4 or p63MAPK) and MAPK6 (also called ERK3 or p97MAPK) are atypical MAPKs that are not regulated by MAPK kinases. MAPK6 is expressed ubiquitously with highest amounts in brain and skeletal muscle. It may be involved in the control of cell differentiation by negatively regulating cell cycle progression in certain conditions. It may also play a role in glucose-induced insulin secretion. MAPK6 and MAPK4 cooperate to regulate the activity of MAPK-activated protein kinase 5 (MK5), leading to its relocation to the cytoplasm and exclusion from the nucleus. The MAPK6/MK5 and MAPK4/MK5 pathways may play critical roles in embryonic and post-natal development. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143359 [Multi-domain]  Cd Length: 342  Bit Score: 93.30  E-value: 9.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPAEDN------------LYLVFDL----LRKgpVMEvpcDKPFPEEQARLYLRDIIL 261
Cdd:cd07854    51 REIKIIRRLDHDNIVKVYEVLGPSGSDLtedvgsltelnsVYIVQEYmetdLAN--VLE---QGPLSEEHARLFMYQLLR 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLHCQKIVHRDIKPSNLLLG-DDGHVKIADFGVS---NQFEGNDAQLSSTAGTPAFMAPEAISdSGQSFSgKALDVW 337
Cdd:cd07854   126 GLKYIHSANVLHRDLKPANVFINtEDLVLKIGDFGLArivDPHYSHKGYLSEGLVTKWYRSPRLLL-SPNNYT-KAIDMW 203
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 338 ATGVTLYCFVYGKCPF-----------IDDYILTLHRKIKNEAV-VFPEE----------------PEVSEDLKDLILRM 389
Cdd:cd07854   204 AAGCIFAEMLTGKPLFagaheleqmqlILESVPVVREEDRNELLnVIPSFvrndggeprrplrdllPGVNPEALDFLEQI 283
                         250
                  ....*....|....*....
gi 1384865967 390 LDKNPETRIGVSDIKLHPW 408
Cdd:cd07854   284 LTFNPMDRLTAEEALMHPY 302
STKc_CDK1_euk cd07861
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher ...
133-408 9.31e-21

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression. CDK1/cyclin A2 has also been implicated as an important regulator of S phase events. The CDK1/cyclin B complex is critical for G2 to M phase transition. It induces mitosis by activating nuclear enzymes that regulate chromatin condensation, nuclear membrane degradation, mitosis-specific microtubule and cytoskeletal reorganization. CDK1 also associates with cyclin E and plays a role in the entry into S phase. CDK1 transcription is stable throughout the cell cycle but is modulated in some pathological conditions. It may play a role in regulating apoptosis under these conditions. In breast cancer cells, HER2 can mediate apoptosis by inactivating CDK1. Activation of CDK1 may contribute to HIV-1 induced apoptosis as well as neuronal apoptosis in neurodegenerative diseases. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270845 [Multi-domain]  Cd Length: 285  Bit Score: 92.48  E-value: 9.31e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 133 EIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLlplervyQEIAILKKLDHVNVV 212
Cdd:cd07861     7 KIGEGTYGVVYKGRNKKTGQIVAMKKI-----------------RLESEEEGVPSTAI-------REISLLKELQHPNIV 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 213 KLIEVLDDpaEDNLYLVFDLLR---KGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHV 289
Cdd:cd07861    63 CLEDVLMQ--ENRLYLVFEFLSmdlKKYLDSLPKGKYMDAELVKSYLYQILQGILFCHSRRVLHRDLKPQNLLIDNKGVI 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 290 KIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSgQSFSgKALDVWATGvTLYCFVYGKCPFI--DDYILTLHR---- 363
Cdd:cd07861   141 KLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGS-PRYS-TPVDIWSIG-TIFAEMATKKPLFhgDSEIDQLFRifri 217
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 364 -------------KIKNEAVVFPE---------EPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd07861   218 lgtptediwpgvtSLPDYKNTFPKwkkgslrtaVKNLDEDGLDLLEKMLIYDPAKRISAKKALVHPY 284
STKc_LATS2 cd05626
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2; STKs ...
196-408 1.19e-20

Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS2 is an essential mitotic regulator responsible for coordinating accurate cytokinesis completion and governing the stabilization of other mitotic regulators. It is also critical in the maintenance of proper chromosome number, genomic stability, mitotic fidelity, and the integrity of centrosome duplication. Downregulation of LATS2 is associated with poor prognosis in acute lymphoblastic leukemia and breast cancer. The LATS2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173715 [Multi-domain]  Cd Length: 381  Bit Score: 93.54  E-value: 1.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 196 VYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCD-KPFPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd05626    48 VKAERDILAEADNEWVVKLYYSFQD--KDNLYFVMDYIPGGDMMSLLIRmEVFPEVLARFYIAELTLAIESVHKMGFIHR 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQF----------EGNDAQLSST---------------------------------- 310
Cdd:cd05626   126 DIKPDNILIDLDGHIKLTDFGLCTGFrwthnskyyqKGSHIRQDSMepsdlwddvsncrcgdrlktleqratkqhqrcla 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 311 ---AGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKN--EAVVFPEEPEVSEDLKDL 385
Cdd:cd05626   206 hslVGTPNYIAPEVLLRKGYT---QLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINweNTLHIPPQVKLSPEAVDL 282
                         250       260
                  ....*....|....*....|....*
gi 1384865967 386 ILRMLDKNPET--RIGVSDIKLHPW 408
Cdd:cd05626   283 ITKLCCSAEERlgRNGADDIKAHPF 307
STKc_Nek7 cd08229
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
198-401 1.24e-20

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek7 is required for mitotic spindle formation and cytokinesis. It is enriched in the centrosome and is critical for microtubule nucleation. Nek7 is activated by Nek9 during mitosis, and may regulate the p70 ribosomal S6 kinase. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270866 [Multi-domain]  Cd Length: 292  Bit Score: 92.02  E-value: 1.24e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEV-----PCDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd08229    73 KEIDLLKQLNHPNVIKYYASFIE--DNELNIVLELADAGDLSRMikhfkKQKRLIPEKTVWKYFVQLCSALEHMHSRRVM 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGkalDVWATGVTLYCFVYGKCP 352
Cdd:cd08229   151 HRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKS---DIWSLGCLLYEMAALQSP 227
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 353 FIDDY--ILTLHRKIknEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIGVS 401
Cdd:cd08229   228 FYGDKmnLYSLCKKI--EQCDYPPLPsdHYSEELRQLVNMCINPDPEKRPDIT 278
PK_TRB cd13976
Pseudokinase domain of Tribbles Homolog proteins; The pseudokinase domain shows similarity to ...
245-408 1.39e-20

Pseudokinase domain of Tribbles Homolog proteins; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Tribbles Homolog (TRB) proteins interact with many proteins involved in signaling pathways. They play scaffold-like regulatory functions and affect many cellular processes such as mitosis, apoptosis, differentiation, and gene expression. TRB proteins bind to the middle kinase in mitogen activated protein kinase (MAPK) signaling cascades, MAPK kinases. They regulate the activity of MAPK kinases, and thus, affect MAPK signaling. In Drosophila, Tribbles regulates String, the ortholog of mammalian Cdc25, during morphogenesis. String is implicated in the progression of mitosis during embryonic development. Vertebrates contain three TRB proteins encoded by three separate genes: Tribbles-1 (TRB1 or TRIB1), Tribbles-2 (TRB2 or TRIB2), and Tribbles-3 (TRB3 or TRIB3). The TRB subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270878 [Multi-domain]  Cd Length: 242  Bit Score: 90.95  E-value: 1.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 245 KPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGH--VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEaI 322
Cdd:cd13976    79 KRLREPEAARLFRQIASAVAHCHRNGIVLRDLKLRKFVFADEERtkLRLESLEDAVILEGEDDSLSDKHGCPAYVSPE-I 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 323 SDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSD 402
Cdd:cd13976   158 LNSGATYSGKAADVWSLGVILYTMLVGRYPFHDSEPASLFAKIRRGQFAIPE--TLSPRARCLIRSLLRREPSERLTAED 235

                  ....*.
gi 1384865967 403 IKLHPW 408
Cdd:cd13976   236 ILLHPW 241
PKc_Myt1 cd14050
Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze ...
128-407 1.84e-20

Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Myt1 is a cytoplasmic cell cycle checkpoint kinase that can keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of N-terminal thr (T14) and tyr (Y15) residues, leading to the delay of meiosis I entry. Meiotic progression is ensured by a two-step inhibition and downregulation of Myt1 by CDK1/XRINGO and p90Rsk during oocyte maturation. In addition, Myt1 targets cyclin B1/B2 and is essential for Golgi and ER assembly during telophase. In Drosophila, Myt1 may be a downstream target of Notch during eye development. The Myt1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270952 [Multi-domain]  Cd Length: 249  Bit Score: 90.45  E-value: 1.84e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprRPPPRGSQATQggpakqllpleRVYQEIAILKKL- 206
Cdd:cd14050     3 FTILSKLGEGSFGEVFKVRSREDGKLYAVKRS-------------RSRFRGEKDRK-----------RKLEEVERHEKLg 58
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDpaEDNLYLVFDLLRKGpvMEVPCDK--PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14050    59 EHPNCVRFIKAWEE--KGILYIQTELCDTS--LQQYCEEthSLPESEVWNILLDLLKGLKHLHDHGLIHLDIKPANIFLS 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAIsdsgQSFSGKALDVWATGVTLY---CFV----YGkcpfiddy 357
Cdd:cd14050   135 KDGVCKLGDFGLVVELDKEDI-HDAQEGDPRYMAPELL----QGSFTKAADIFSLGITILelaCNLelpsGG-------- 201
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 358 ilTLHRKIKNEAVvfPEE--PEVSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd14050   202 --DGWHQLRQGYL--PEEftAGLSPELRSIIKLMMDPDPERRPTAEDLLALP 249
STKc_Pho85 cd07836
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; ...
198-408 2.01e-20

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Pho85 is a multifunctional CDK in yeast. It is regulated by 10 different cyclins (Pcls) and plays a role in G1 progression, cell polarity, phosphate and glycogen metabolism, gene expression, and in signaling changes in the environment. It is not essential for yeast viability and is the functional homolog of mammalian CDK5, which plays a role in central nervous system development. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The Pho85 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143341 [Multi-domain]  Cd Length: 284  Bit Score: 91.39  E-value: 2.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVF-----DLLRKGPVMEVPCdkPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd07836    47 REISLMKELKHENIVRLHDVIH--TENKLMLVFeymdkDLKKYMDTHGVRG--ALDPNTVKSFTYQLLKGIAFCHENRVL 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSgQSFSgKALDVWATGVTLYCFVYGKCP 352
Cdd:cd07836   123 HRDLKPQNLLINKRGELKLADFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGS-RTYS-TSIDIWSVGCIMAEMITGRPL 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 353 FI----DDYILTLHR-----------------KIKNEAVVFPEE------PEVSEDLKDLILRMLDKNPETRIGVSDIKL 405
Cdd:cd07836   201 FPgtnnEDQLLKIFRimgtptestwpgisqlpEYKPTFPRYPPQdlqqlfPHADPLGIDLLHRLLQLNPELRISAHDALQ 280

                  ...
gi 1384865967 406 HPW 408
Cdd:cd07836   281 HPW 283
STKc_RIP1 cd14027
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze ...
194-403 3.27e-20

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP1 harbors a C-terminal Death domain (DD), which binds death receptors (DRs) including TNF receptor 1, Fas, TNF-related apoptosis-inducing ligand receptor 1 (TRAILR1), and TRAILR2. It also interacts with other DD-containing adaptor proteins such as TRADD and FADD. RIP1 can also recruit other kinases including MEKK1, MEKK3, and RIP3 through an intermediate domain (ID) that bears a RIP homotypic interaction motif (RHIM). RIP1 plays a crucial role in determining a cell's fate, between survival or death, following exposure to stress signals. It is important in the signaling of NF-kappaB and MAPKs, and it links DR-associated signaling to reactive oxygen species (ROS) production. Abnormal RIP1 function may result in ROS accummulation affecting inflammatory responses, innate immunity, stress responses, and cell survival. RIP kinases serve as essential sensors of cellular stress. The RIP1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270929 [Multi-domain]  Cd Length: 267  Bit Score: 90.25  E-value: 3.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLddpAEDNLY-LVFDLLRKGPVMEVPCDKPFP-EEQARLYLrDIILGLEYLHCQKI 271
Cdd:cd14027    36 EALLEEGKMMNRLRHSRVVKLLGVI---LEEGKYsLVMEYMEKGNLMHVLKKVSVPlSVKGRIIL-EIIEGMAYLHGKGV 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGV-------------SNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKAlDVWA 338
Cdd:cd14027   112 IHKDLKPENILVDNDFHIKIADLGLasfkmwskltkeeHNEQREVDGTAKKNAGTLYYMAPEHLNDVNAKPTEKS-DVYS 190
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 339 TGVTLYCFVYGKCPFID----DYIL--TLHRKIKNEAVVFPEEPevsEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd14027   191 FAIVLWAIFANKEPYENaineDQIImcIKSGNRPDVDDITEYCP---REIIDLMKLCWEANPEARPTFPGI 258
STKc_p38alpha cd07877
Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase ...
127-421 3.35e-20

Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38alpha/MAPK14 is expressed in most tissues and is the major isoform involved in the immune and inflammatory response. It is the central p38 MAPK involved in myogenesis. It plays a role in regulating cell cycle check-point transition and promoting cell differentiation. p38alpha also regulates cell proliferation and death through crosstalk with the JNK pathway. Its substrates include MAPK activated protein kinase 2 (MK2), MK5, and the transcription factors ATF2 and Mitf. p38 kinases MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143382 [Multi-domain]  Cd Length: 345  Bit Score: 91.64  E-value: 3.35e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrppprgsqatqggPAKQLLPLERVYQEIAILKKL 206
Cdd:cd07877    18 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSR------------------------PFQSIIHAKRTYRELRLLKHM 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDdPAE-----DNLYLVFDLLRKGPVMEVPCDKpFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNL 281
Cdd:cd07877    74 KHENVIGLLDVFT-PARsleefNDVYLVTHLMGADLNNIVKCQK-LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNL 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 282 LLGDDGHVKIADFGVSNQfegNDAQLSSTAGTPAFMAPEAISDsgQSFSGKALDVWATGVTLYCFVYGKCPF-----IDD 356
Cdd:cd07877   152 AVNEDCELKILDFGLARH---TDDEMTGYVATRWYRAPEIMLN--WMHYNQTVDIWSVGCIMAELLTGRTLFpgtdhIDQ 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 357 YILTLH----------RKIKNEAV-----VFPEEPEVS-EDL--------KDLILRMLDKNPETRIGVSDIKLHPWVTKH 412
Cdd:cd07877   227 LKLILRlvgtpgaellKKISSESArnyiqSLTQMPKMNfANVfiganplaVDLLEKMLVLDSDKRITAAQALAHAYFAQY 306

                  ....*....
gi 1384865967 413 GEeplPSEE 421
Cdd:cd07877   307 HD---PDDE 312
STKc_aPKC cd05588
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the ...
223-408 3.47e-20

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270740 [Multi-domain]  Cd Length: 328  Bit Score: 91.33  E-value: 3.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
Cdd:cd05588    68 ESRLFFVIEFVNGGDLMfHMQRQRRLPEEHARFYSAEISLALNFLHEKGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGL 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCPF------------IDDYiltLHRKIKNEA 369
Cdd:cd05588   148 RPGDTTSTFCGTPNYIAPEILRGEDYGFS---VDWWALGVLMFEMLAGRSPFdivgssdnpdqnTEDY---LFQVILEKP 221
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1384865967 370 VVFPEEPEV--SEDLKDLilrmLDKNPETRIG------VSDIKLHPW 408
Cdd:cd05588   222 IRIPRSLSVkaASVLKGF----LNKNPAERLGchpqtgFADIQSHPF 264
STKc_TAO3 cd06633
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze ...
133-417 3.60e-20

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO3 is also known as JIK (c-Jun N-terminal kinase inhibitory kinase) or KFC (kinase from chicken). It specifically activates JNK, presumably by phosphorylating and activating MKK4/MKK7. In Saccharomyces cerevisiae, TAO3 is a component of the RAM (regulation of Ace2p activity and cellular morphogenesis) signaling pathway. TAO3 is upregulated in retinal ganglion cells after axotomy, and may play a role in apoptosis. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270803 [Multi-domain]  Cd Length: 313  Bit Score: 91.25  E-value: 3.60e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 133 EIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfpRRPPPRGSQATQggpakqllPLERVYQEIAILKKLDHVNVV 212
Cdd:cd06633    28 EIGHGSFGAVYFATNSHTNEVVAI---------------KKMSYSGKQTNE--------KWQDIIKEVKFLQQLKHPNTI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 213 KLIEVLDDPAEDNLYLVFDLLRKGPVMEVPcDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd06633    85 EYKGCYLKDHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLA 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGVSNQfegnDAQLSSTAGTPAFMAPEAI--SDSGQsFSGKaLDVWATGVTLYCFVYGKCPFID-DYILTLHRKIKNEA 369
Cdd:cd06633   164 DFGSASI----ASPANSFVGTPYWMAPEVIlaMDEGQ-YDGK-VDIWSLGITCIELAERKPPLFNmNAMSALYHIAQNDS 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 370 VVFpEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKhgEEPL 417
Cdd:cd06633   238 PTL-QSNEWTDSFRGFVDYCLQKIPQERPSSAELLRHDFVRR--ERPP 282
STKc_CDK8_like cd07842
Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs ...
127-340 5.02e-20

Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK8, CDC2L6, and similar proteins. CDK8 functions as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II-dependent transcription. CDC2L6 also associates with Mediator in complexes lacking CDK8. In VP16-dependent transcriptional activation, CDK8 and CDC2L6 exerts opposing effects by positive and negative regulation, respectively, in similar conditions. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270834 [Multi-domain]  Cd Length: 316  Bit Score: 90.81  E-value: 5.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAY--NESEDRHYAMKVLSKKKLLKQyGFprrppprgSQATqggpakqllplervYQEIAILK 204
Cdd:cd07842     1 KYEIEGCIGRGTYGRVYKAKrkNGKDGKEYAIKKFKGDKEQYT-GI--------SQSA--------------CREIALLR 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDDPAEDNLYLVF-----DLL-------RKGPVMevpcdkpFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd07842    58 ELKHENVVSLVEVFLEHADKSVYLLFdyaehDLWqiikfhrQAKRVS-------IPPSMVKSLLWQILNGIHYLHSNWVL 130
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 273 HRDIKPSNLLL----GDDGHVKIADFGVSNQFEGNDAQLSSTAG---TPAFMAPEAIsdSGQSFSGKALDVWATG 340
Cdd:cd07842   131 HRDLKPANILVmgegPERGVVKIGDLGLARLFNAPLKPLADLDPvvvTIWYRAPELL--LGARHYTKAIDIWAIG 203
STKc_MAP4K5 cd06646
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
196-409 5.95e-20

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). MAP4K5 also facilitates Wnt signaling in B cells, and may therefore be implicated in the control of cell fate, proliferation, and polarity. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270813 [Multi-domain]  Cd Length: 268  Bit Score: 89.70  E-value: 5.95e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 196 VYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEV-PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd06646    53 IQQEIFMVKECKHCNIVAYFGSY--LSREKLWICMEYCGGGSLQDIyHVTGPLSELQIAYVCRETLQGLAYLHSKGKMHR 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFI 354
Cdd:cd06646   131 DIKGANILLTDNGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELAELQPPMF 210
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 355 DDY---ILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd06646   211 DLHpmrALFLMSKSNFQPPKLKDKTKWSSTFHNFVKISLTKNPKKRPTAERLLTHLFV 268
STKc_aPKC_iota cd05618
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze ...
223-408 8.15e-20

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270769 [Multi-domain]  Cd Length: 364  Bit Score: 90.86  E-value: 8.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLRKGPVM-EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFE 301
Cdd:cd05618    93 ESRLFFVIEYVNGGDLMfHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGL 172
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 302 GNDAQLSSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCPF------------IDDYILTLhrkIKNEA 369
Cdd:cd05618   173 RPGDTTSTFCGTPNYIAPEILRGEDYGFS---VDWWALGVLMFEMMAGRSPFdivgssdnpdqnTEDYLFQV---ILEKQ 246
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1384865967 370 VVFPEepEVSEDLKDLILRMLDKNPETRIGV------SDIKLHPW 408
Cdd:cd05618   247 IRIPR--SLSVKAASVLKSFLNKDPKERLGChpqtgfADIQGHPF 289
STKc_CDC2L1 cd07843
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze ...
199-408 8.22e-20

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173741 [Multi-domain]  Cd Length: 293  Bit Score: 89.59  E-value: 8.22e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLR---KGpVMEVpCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd07843    54 EINILLKLQHPNIVTVKEVVVGSNLDKIYMVMEYVEhdlKS-LMET-MKQPFLQSEVKCLMLQLLSGVAHLHDNWILHRD 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPF-- 353
Cdd:cd07843   132 LKTSNLLLNNRGILKICDFGLAREYGSPLKPYTQLVVTLWYRAPELL--LGAKEYSTAIDMWSVGCIFAELLTKKPLFpg 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 354 ---ID--DYILTL-----------HRKIKN-EAVVFPEEPE-----------VSEDLKDLILRMLDKNPETRIGVSDIKL 405
Cdd:cd07843   210 kseIDqlNKIFKLlgtptekiwpgFSELPGaKKKTFTKYPYnqlrkkfpalsLSDNGFDLLNRLLTYDPAKRISAEDALK 289

                  ...
gi 1384865967 406 HPW 408
Cdd:cd07843   290 HPY 292
STKc_TNIK cd06637
Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs ...
194-415 8.70e-20

Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TNIK is an effector of Rap2, a small GTP-binding protein from the Ras family. TNIK specifically activates the c-Jun N-terminal kinase (JNK) pathway and plays a role in regulating the actin cytoskeleton. The TNIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270807 [Multi-domain]  Cd Length: 296  Bit Score: 89.78  E-value: 8.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVK-----LIEVLDDPAEDNLYLVFDLLRKGPVMEVPCD---KPFPEEQARLYLRDIILGLEY 265
Cdd:cd06637    47 EEIKQEINMLKKYSHHRNIAtyygaFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNtkgNTLKEEWIAYICREILRGLSH 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS-----DSGQSFSGkalDVWATG 340
Cdd:cd06637   127 LHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAcdenpDATYDFKS---DLWSLG 203
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 341 VTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEE 415
Cdd:cd06637   204 ITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPSTEQLMKHPFIRDQPNE 278
STKc_EIF2AK3_PERK cd14048
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
125-406 1.12e-19

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PERK (or EIF2AK3) is a type-I ER transmembrane protein containing a luminal domain bound with the chaperone BiP under unstressed conditions and a cytoplasmic catalytic kinase domain. In response to the accumulation of misfolded or unfolded proteins in the ER, PERK is activated through the release of BiP, allowing it to dimerize and autophosphorylate. It functions as the central regulator of translational control during the Unfolded Protein Response (UPR) pathway. In addition to the eIF-2 alpha subunit, PERK also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PERK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270950 [Multi-domain]  Cd Length: 281  Bit Score: 89.16  E-value: 1.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKvlskkkllkQYGFPRRPPPRgsqatqggpakqllplERVYQEIAILK 204
Cdd:cd14048     5 LTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAVK---------RIRLPNNELAR----------------EKVLREVRALA 59
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEV-LDDPAED--------NLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIIL----GLEYLHCQKI 271
Cdd:cd14048    60 KLDHPGIVRYFNAwLERPPEGwqekmdevYLYIQMQLCRKENLKDWMNRRCTMESRELFVCLNIFKqiasAVEYLHSKGL 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGVSNQFEGND------------AQLSSTAGTPAFMAPEAIsdSGQSFSGKaLDVWAT 339
Cdd:cd14048   140 IHRDLKPSNVFFSLDDVVKVGDFGLVTAMDQGEpeqtvltpmpayAKHTGQVGTRLYMSPEQI--HGNQYSEK-VDIFAL 216
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 340 GVTLYCFVYgkcPFIDD----YILTLHRKIKNEAVVFPEEPEVSedlkDLILRMLDKNPETRIGVSDIKLH 406
Cdd:cd14048   217 GLILFELIY---SFSTQmeriRTLTDVRKLKFPALFTNKYPEER----DMVQQMLSPSPSERPEAHEVIEH 280
STKc_NAK_like cd14037
Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze ...
193-397 1.60e-19

Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Drosophila melanogaster NAK, human BMP-2-inducible protein kinase (BMP2K or BIKe) and similar vertebrate proteins, as well as the Saccharomyces cerevisiae proteins Prk1, Actin-regulating kinase 1 (Ark1), and Akl1. NAK was the first characterized member of this subfamily. It plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. BMP2K contains a nuclear localization signal and a kinase domain that is capable of phosphorylating itself and myelin basic protein. The expression of the BMP2K gene is increase during BMP-2-induced osteoblast differentiation. It may function to control the rate of differentiation. Prk1, Ark1, and Akl1 comprise a subfamily of yeast proteins that are important regulators of the actin cytoskeleton and endocytosis. They share an N-terminal kinase domain but no significant homology in other regions of their sequences. The NAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270939 [Multi-domain]  Cd Length: 277  Bit Score: 88.49  E-value: 1.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKL-DHVNVVKLIEVLDDPAEDNLYLVFDLL---RKGPV---MEVPCDKPFPEEQARLYLRDIILGLEY 265
Cdd:cd14037    44 LNVCKREIEIMKRLsGHKNIVGYIDSSANRSGNGVYEVLLLMeycKGGGVidlMNQRLQTGLTESEILKIFCDVCEAVAA 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQK--IVHRDIKPSNLLLGDDGHVKIADFG-VSNQFEGNDAQLSSTA--------GTPAFMAPEAIS-DSGQSFSGKA 333
Cdd:cd14037   124 MHYLKppLIHRDLKVENVLISDSGNYKLCDFGsATTKILPPQTKQGVTYveedikkyTTLQYRAPEMIDlYRGKPITEKS 203
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 334 lDVWATGVTLYCFVYGKCPFIDDYILTlhrkIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd14037   204 -DIWALGCLLYKLCFYTTPFEESGQLA----ILNGNFTFPDNSRYSKRLHKLIRYMLEEDPEKR 262
STKc_MLK cd14061
Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the ...
193-353 1.62e-19

Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLKs act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Mammals have four MLKs (MLK1-4), mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270963 [Multi-domain]  Cd Length: 258  Bit Score: 88.22  E-value: 1.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEV-LDDPaedNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQK- 270
Cdd:cd14061    37 LENVRQEARLFWMLRHPNIIALRGVcLQPP---NLCLVMEYARGGALNRVLAGRKIPPHVLVDWAIQIARGMNYLHNEAp 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 --IVHRDIKPSNLLL------GDDGH--VKIADFGVSNqfEGNDAQLSSTAGTPAFMAPEAISDSgqSFSgKALDVWATG 340
Cdd:cd14061   114 vpIIHRDLKSSNILIleaienEDLENktLKITDFGLAR--EWHKTTRMSAAGTYAWMAPEVIKSS--TFS-KASDVWSYG 188
                         170
                  ....*....|...
gi 1384865967 341 VTLYCFVYGKCPF 353
Cdd:cd14061   189 VLLWELLTGEVPY 201
STKc_CDKL2_3 cd07846
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; ...
198-340 1.64e-19

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL2, also called p56 KKIAMRE, is expressed in testis, kidney, lung, and brain. It functions mainly in mature neurons and plays an important role in learning and memory. Inactivation of CDKL3, also called NKIAMRE (NKIATRE in rat), by translocation is associated with mild mental retardation. It has been reported that CDKL3 is lost in leukemic cells having a chromosome arm 5q deletion, and may contribute to the transformed phenotype. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270836 [Multi-domain]  Cd Length: 286  Bit Score: 88.63  E-value: 1.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVpcdKPFP----EEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:cd07846    49 REIKMLKQLRHENLVNLIEVFRR--KKRWYLVFEFVDHTVLDDL---EKYPngldESRVRKYLFQILRGIDFCHSHNIIH 123
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 274 RDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATG 340
Cdd:cd07846   124 RDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELL--VGDTKYGKAVDVWAVG 188
STKc_NLK cd07853
Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer ...
190-408 1.65e-19

Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NLK is an atypical mitogen-activated protein kinase (MAPK) that is not regulated by a MAPK kinase. It functions downstream of the MAPK kinase kinase Tak1, which also plays a role in activating the JNK and p38 MAPKs. The Tak1/NLK pathways are regulated by Wnts, a family of secreted proteins that is critical in the control of asymmetric division and cell polarity. NLK can phosphorylate transcription factors from the TCF/LEF family, inhibiting their ability to activate the transcription of target genes. In prostate cancer cells, NLK is involved in regulating androgen receptor-mediated transcription and its expression is altered during cancer progression. MAPKs are important mediators of cellular responses to extracellular signals. The NLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173748 [Multi-domain]  Cd Length: 372  Bit Score: 90.19  E-value: 1.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 190 LLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAED---NLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYL 266
Cdd:cd07853    40 LVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDpfeEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYL 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 267 HCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQ-LSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYC 345
Cdd:cd07853   120 HSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEEPDESKhMTQEVVTQYYRAPEIL--MGSRHYTSAVDIWSVGCIFAE 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 346 FVYGKCPF-----------IDD-------------------YILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPE 395
Cdd:cd07853   198 LLGRRILFqaqspiqqldlITDllgtpsleamrsacegaraHILRGPHKPPSLPVLYTLSSQATHEAVHLLCRMLVFDPD 277
                         250
                  ....*....|...
gi 1384865967 396 TRIGVSDIKLHPW 408
Cdd:cd07853   278 KRISAADALAHPY 290
PKc_PBS2_like cd06622
Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
248-413 1.97e-19

Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Polymyxin B resistance protein 2 (PBS2) from Saccharomyces cerevisiae, Wis1 from Schizosaccharomyces pombe, and related proteins. PBS2 and Wis1 are components of stress-activated MAPK cascades in budding and fission yeast, respectively. PBS2 is the specific activator of the MAPK Hog1, which plays a central role in the response of budding yeast to stress including exposure to arsenite and hyperosmotic environments. Wis1 phosphorylates and activates the MAPK Sty1 (also called Spc1 or Phh1), which stimulates a transcriptional response to a wide range of cellular insults through the bZip transcription factors Atf1, Pcr1, and Pap1. The PBS2 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132953 [Multi-domain]  Cd Length: 286  Bit Score: 88.37  E-value: 1.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 248 PEEQARLYLRDIILGLEYLHCQ-KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEgndAQLSST-AGTPAFMAPEAISDS 325
Cdd:cd06622   100 PEDVLRRITYAVVKGLKFLKEEhNIIHRDVKPTNVLVNGNGQVKLCDFGVSGNLV---ASLAKTnIGCQSYMAPERIKSG 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 326 GQSFSGK---ALDVWATGVTLYCFVYGKCPFIDDYILTLHRKIknEAVVFPEEP----EVSEDLKDLILRMLDKNPETRI 398
Cdd:cd06622   177 GPNQNPTytvQSDVWSLGLSILEMALGRYPYPPETYANIFAQL--SAIVDGDPPtlpsGYSDDAQDFVAKCLNKIPNRRP 254
                         170
                  ....*....|....*
gi 1384865967 399 GVSDIKLHPWVTKHG 413
Cdd:cd06622   255 TYAQLLEHPWLVKYK 269
PTZ00267 PTZ00267
NIMA-related protein kinase; Provisional
199-397 2.04e-19

NIMA-related protein kinase; Provisional


Pssm-ID: 140293 [Multi-domain]  Cd Length: 478  Bit Score: 90.85  E-value: 2.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEvlDDPAEDNLYLVFDL-----LRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:PTZ00267  115 ELHCLAACDHFGIVKHFD--DFKSDDKLLLIMEYgsggdLNKQIKQRLKEHLPFQEYEVGLLFYQIVLALDEVHSRKMMH 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLGDDGHVKIADFGVSNQFEgNDAQL---SSTAGTPAFMAPEAISDsgQSFSGKAlDVWATGVTLYcfvygk 350
Cdd:PTZ00267  193 RDLKSANIFLMPTGIIKLGDFGFSKQYS-DSVSLdvaSSFCGTPYYLAPELWER--KRYSKKA-DMWSLGVILY------ 262
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 351 cpfiddYILTLHRKIKN-------EAVVF----PEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:PTZ00267  263 ------ELLTLHRPFKGpsqreimQQVLYgkydPFPCPVSSGMKALLDPLLSKNPALR 314
PTKc_Syk_like cd05060
Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
199-397 2.73e-19

Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Syk-like subfamily is composed of Syk, ZAP-70, Shark, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. They are involved in the signaling downstream of activated receptors (including B-cell, T-cell, and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. Syk is important in B-cell receptor signaling, while Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor signaling. Syk also plays a central role in Fc receptor-mediated phagocytosis in the adaptive immune system. Shark is exclusively expressed in ectodermally derived epithelia, and is localized preferentially to the apical surface of the epithelial cells, it may play a role in a signaling pathway for epithelial cell polarity. The Syk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270650 [Multi-domain]  Cd Length: 257  Bit Score: 87.40  E-value: 2.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPAednLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd05060    46 EASVMAQLDHPCIVRLIGVCKGEP---LMLVMELAPLGPLLKYLKKRReIPVSDLKELAHQVAMGMAYLESKHFVHRDLA 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 278 PSNLLLGDDGHVKIADFGVSNQFE-GNDAQLSSTAGT-P-AFMAPEAISDSgqSFSGKAlDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05060   123 ARNVLLVNRHQAKISDFGMSRALGaGSDYYRATTAGRwPlKWYAPECINYG--KFSSKS-DVWSYGVTLWeAFSYGAKPY 199
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 354 iddyiltlhRKIKNEAVV--------FPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd05060   200 ---------GEMKGPEVIamlesgerLPRPEECPQEIYSIMLSCWKYRPEDR 242
STKc_Sid2p_like cd05600
Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; STKs catalyze the ...
124-412 2.79e-19

Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This group contains fungal kinases including Schizosaccharomyces pombe Sid2p and Saccharomyces cerevisiae Dbf2p. Group members show similarity to NDR kinases in that they contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Sid2p plays a crucial role in the septum initiation network (SIN) and in the initiation of cytokinesis. Dbf2p is important in regulating the mitotic exit network (MEN) and in cytokinesis. The Sid2p-like group is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270751 [Multi-domain]  Cd Length: 386  Bit Score: 89.71  E-value: 2.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 124 QLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygfprrppprgsqatqggpaKQLL----PLERVYQE 199
Cdd:cd05600     9 KLSDFQILTQVGQGGYGSVFLARKKDTGEICALKIMK---------------------------KKVLfklnEVNHVLTE 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 200 IAILKKLDHVNVVKLIEVLDDPaeDNLYLVfdllrkgpvMEVPCDKPF----------PEEQARLYLRDIILGLEYLHCQ 269
Cdd:cd05600    62 RDILTTTNSPWLVKLLYAFQDP--ENVYLA---------MEYVPGGDFrtllnnsgilSEEHARFYIAEMFAAISSLHQL 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 270 KIVHRDIKPSNLLLGDDGHVKIADFGVSNQF------EGNDAQLS-------------------------------STAG 312
Cdd:cd05600   131 GYIHRDLKPENFLIDSSGHIKLTDFGLASGTlspkkiESMKIRLEevkntafleltakerrniyramrkedqnyanSVVG 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 313 TPAFMAPEAISDSGQSFSgkaLDVWATGVTLYCFVYGKCPF-----------IDDYILTLHRKIKNEAvvfPEEPEVSED 381
Cdd:cd05600   211 SPDYMAPEVLRGEGYDLT---VDYWSLGCILFECLVGFPPFsgstpnetwanLYHWKKTLQRPVYTDP---DLEFNLSDE 284
                         330       340       350
                  ....*....|....*....|....*....|..
gi 1384865967 382 LKDLILRMLDkNPETRI-GVSDIKLHPWVTKH 412
Cdd:cd05600   285 AWDLITKLIT-DPQDRLqSPEQIKNHPFFKNI 315
PKc_MKK4 cd06616
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
133-425 5.03e-19

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK4 is a dual-specificity PK that phosphorylates and activates the downstream targets, c-Jun N-terminal kinase (JNK) and p38 MAPK, on specific threonine and tyrosine residues. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. Their activation is associated with the induction of cell death. Mice deficient in MKK4 die during embryogenesis and display anemia, severe liver hemorrhage, and abnormal hepatogenesis. MKK4 may also play roles in the immune system and in cardiac hypertrophy. It plays a major role in cancer as a tumor and metastasis suppressor. Under certain conditions, MKK4 is pro-oncogenic. The MKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270790 [Multi-domain]  Cd Length: 291  Bit Score: 87.42  E-value: 5.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 133 EIGKGAYGVVRLAYNESEDRHYAMKvlskkkllkqygfprrpppRGSQATQGGPAKQLLplervyQEI-AILKKLDHVNV 211
Cdd:cd06616    13 EIGRGAFGTVNKMLHKPSGTIMAVK-------------------RIRSTVDEKEQKRLL------MDLdVVMRSSDCPYI 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 212 VKL-------------IEvLDDPAEDNLY-LVFDLLRKgpvmevpcdkPFPEEqarlylrdiILG---------LEYLHC 268
Cdd:cd06616    68 VKFygalfregdcwicME-LMDISLDKFYkYVYEVLDS----------VIPEE---------ILGkiavatvkaLNYLKE 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 269 Q-KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQlSSTAGTPAFMAPEAIsDSGQSFSGKAL--DVWATGVTLYC 345
Cdd:cd06616   128 ElKIIHRDVKPSNILLDRNGNIKLCDFGISGQLVDSIAK-TRDAGCRPYMAPERI-DPSASRDGYDVrsDVWSLGITLYE 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 346 FVYGKCPF--IDDYILTLHRKIKNEAVVFP--EEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEEPLPSEE 421
Cdd:cd06616   206 VATGKFPYpkWNSVFDQLTQVVKGDPPILSnsEEREFSPSFVNFVNLCLIKDESKRPKYKELLKHPFIKMYEERNVDVAA 285

                  ....
gi 1384865967 422 EHCS 425
Cdd:cd06616   286 YVQK 289
STKc_PIM2 cd14101
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
127-409 5.22e-19

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are three PIM2 isoforms resulting from alternative translation initiation sites. PIM2 is highly expressed in leukemia and lymphomas and has been shown to promote the survival and proliferation of tumor cells. The PIM2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271003 [Multi-domain]  Cd Length: 257  Bit Score: 86.44  E-value: 5.22e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPPPRGSQATQGGPAkqllPLErvyqeIAILKKL 206
Cdd:cd14101     1 QYTMGNLLGKGGFGTVYAGHRISDGLQVAIKQ-----------ISRNRVQQWSKLPGVNPV----PNE-----VALLQSV 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 ----DHVNVVKLIEVLDDPAEdnLYLVFDllRKGPVME----VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKP 278
Cdd:cd14101    61 gggpGHRGVIRLLDWFEIPEG--FLLVLE--RPQHCQDlfdyITERGALDESLARRFFKQVVEAVQHCHSKGVVHRDIKD 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 279 SNLLLG-DDGHVKIADFGVSNQFEgnDAQLSSTAGTPAFMAPEAISDsgQSFSGKALDVWATGVTLYCFVYGKCPFIDDy 357
Cdd:cd14101   137 ENILVDlRTGDIKLIDFGSGATLK--DSMYTDFDGTRVYSPPEWILY--HQYHALPATVWSLGILLYDMVCGDIPFERD- 211
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 358 iltlhRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14101   212 -----TDILKAKPSFNK--RVSNDCRSLIRSCLAYNPSDRPSLEQILLHPWM 256
STKc_MAP4K4_6_N cd06636
N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase ...
194-355 1.35e-18

N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K4 is also called Nck Interacting kinase (NIK). It facilitates the activation of the MAPKs, extracellular signal-regulated kinase (ERK) 1, ERK2, and c-Jun N-terminal kinase (JNK), by phosphorylating and activating MEKK1. MAP4K4 plays a role in tumor necrosis factor (TNF) alpha-induced insulin resistance. MAP4K4 silencing in skeletal muscle cells from type II diabetic patients restores insulin-mediated glucose uptake. MAP4K4, through JNK, also plays a broad role in cell motility, which impacts inflammation, homeostasis, as well as the invasion and spread of cancer. MAP4K4 is found to be highly expressed in most tumor cell lines relative to normal tissue. MAP4K6 (also called MINK for Misshapen/NIKs-related kinase) is activated after Ras induction and mediates activation of p38 MAPK. MAP4K6 plays a role in cell cycle arrest, cytoskeleton organization, cell adhesion, and cell motility. The MAP4K4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270806 [Multi-domain]  Cd Length: 282  Bit Score: 85.83  E-value: 1.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIE---VLDDPA--EDNLYLVFDLLRKGPVMEVPCD---KPFPEEQARLYLRDIILGLEY 265
Cdd:cd06636    57 EEIKLEINMLKKYSHHRNIATYYgafIKKSPPghDDQLWLVMEFCGAGSVTDLVKNtkgNALKEDWIAYICREILRGLAH 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIS-----DSGQSFSGkalDVWATG 340
Cdd:cd06636   137 LHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIAcdenpDATYDYRS---DIWSLG 213
                         170
                  ....*....|....*
gi 1384865967 341 VTLYCFVYGKCPFID 355
Cdd:cd06636   214 ITAIEMAEGAPPLCD 228
STKc_GRK3 cd05633
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs ...
123-399 1.71e-18

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK3, also called beta-adrenergic receptor kinase 2 (beta-ARK2), is widely expressed in many tissues. It is involved in modulating the cholinergic response of airway smooth muscles, and also plays a role in dopamine receptor regulation. GRK3-deficient mice show a lack of olfactory receptor desensitization and altered regulation of the M2 muscarinic airway. GRK3 promoter polymorphisms may also be associated with bipolar disorder. GRK3 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270781 [Multi-domain]  Cd Length: 346  Bit Score: 86.65  E-value: 1.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGfprrppprgsqatqggpaKQLLPLERVYqeIAI 202
Cdd:cd05633     2 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG------------------ETLALNERIM--LSL 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 203 LKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPV-MEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNL 281
Cdd:cd05633    62 VSTGDCPFIVCMTYAFHTP--DKLCFILDLMNGGDLhYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANI 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 282 LLGDDGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAISdSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTL 361
Cdd:cd05633   140 LLDEHGHVRISDLGLACDFSKKKPH--ASVGTHGYMAPEVLQ-KGTAYDSSA-DWFSLGCMLFKLLRGHSPFRQHKTKDK 215
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1384865967 362 HRKIKNEAVVFPEEPEV-SEDLKDLILRMLDKNPETRIG 399
Cdd:cd05633   216 HEIDRMTLTVNVELPDSfSPELKSLLEGLLQRDVSKRLG 254
PTKc_FAK cd05056
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the ...
194-404 1.73e-18

Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FAK is a cytoplasmic (or nonreceptor) PTK that contains an autophosphorylation site and a FERM domain at the N-terminus, a central tyr kinase domain, proline-rich regions, and a C-terminal FAT (focal adhesion targeting) domain. FAK activity is dependent on integrin-mediated cell adhesion, which facilitates N-terminal autophosphorylation. Full activation is achieved by the phosphorylation of its two adjacent A-loop tyrosines. FAK is important in mediating signaling initiated at sites of cell adhesions and at growth factor receptors. Through diverse molecular interactions, FAK functions as a biosensor or integrator to control cell motility. It is a key regulator of cell survival, proliferation, migration and invasion, and thus plays an important role in the development and progression of cancer. Src binds to autophosphorylated FAK forming the FAK-Src dual kinase complex, which is activated in a wide variety of tumor cells and generates signals promoting growth and metastasis. FAK is being developed as a target for cancer therapy. The FAK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133187 [Multi-domain]  Cd Length: 270  Bit Score: 85.55  E-value: 1.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAednLYLVFDLLRKGPVMEVpcdkpFPEEQARLYLRDIIL-------GLEYL 266
Cdd:cd05056    52 EKFLQEAYIMRQFDHPHIVKLIGVITENP---VWIVMELAPLGELRSY-----LQVNKYSLDLASLILyayqlstALAYL 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 267 HCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAIsdSGQSFSgKALDVWATGVTLY- 344
Cdd:cd05056   124 ESKRFVHRDIAARNVLVSSPDCVKLGDFGLSRYMEDESYYKASKGKLPiKWMAPESI--NFRRFT-SASDVWMFGVCMWe 200
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 345 CFVYGKCPFiddyiltlhRKIKNEAVV--------FPEEPEVSEDLKDLILRMLDKNPETRIGVSDIK 404
Cdd:cd05056   201 ILMLGVKPF---------QGVKNNDVIgriengerLPMPPNCPPTLYSLMTKCWAYDPSKRPRFTELK 259
STKc_MLK3 cd14147
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the ...
194-403 2.09e-18

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK3 is a mitogen-activated protein kinase kinase kinases (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK3 activates multiple MAPK pathways and plays a role in apoptosis, proliferation, migration, and differentiation, depending on the cellular context. It is highly expressed in breast cancer cells and its signaling through c-Jun N-terminal kinase has been implicated in the migration, invasion, and malignancy of cancer cells. MLK3 also functions as a negative regulator of Inhibitor of Nuclear Factor-KappaB Kinase (IKK) and consequently, it also impacts inflammation and immunity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271049 [Multi-domain]  Cd Length: 267  Bit Score: 85.08  E-value: 2.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEV-LDDPaedNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd14147    47 ESVRQEARLFAMLAHPNIIALKAVcLEEP---NLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALV 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 ---HRDIKPSNLLLG--------DDGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAISDSgqSFsGKALDVWATGV 341
Cdd:cd14147   124 pviHRDLKSNNILLLqpienddmEHKTLKITDFGLAREWHKTTQM--SAAGTYAWMAPEVIKAS--TF-SKGSDVWSFGV 198
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 342 TLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd14147   199 LLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASI 260
PTKc_Src_like cd05034
Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
198-397 3.31e-18

Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src subfamily members include Src, Lck, Hck, Blk, Lyn, Fgr, Fyn, Yrk, and Yes. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. They are also implicated in acute inflammatory responses and osteoclast function. Src, Fyn, Yes, and Yrk are widely expressed, while Blk, Lck, Hck, Fgr, and Lyn show a limited expression pattern. The Src-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270630 [Multi-domain]  Cd Length: 248  Bit Score: 83.87  E-value: 3.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEvpcdkpfpeeqarlYLRD-----------------II 260
Cdd:cd05034    39 QEAQIMKKLRHDKLVQLYAVCSD--EEPIYIVTELMSKGSLLD--------------YLRTgegralrlpqlidmaaqIA 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 261 LGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAISDsgQSFSGKAlDVWAT 339
Cdd:cd05034   103 SGMAYLESRNYIHRDLAARNILVGENNVCKVADFGLARLIEDDEYTAREGAKFPiKWTAPEAALY--GRFTIKS-DVWSF 179
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 340 GVTLY-CFVYGKCPFiddyiltlhRKIKNEAVV--------FPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd05034   180 GILLYeIVTYGRVPY---------PGMTNREVLeqvergyrMPKPPGCPDELYDIMLQCWKKEPEER 237
PKc_MKK5 cd06619
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
259-409 3.44e-18

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK5 (also called MEK5) is a dual-specificity PK that phosphorylates its downstream target, extracellular signal-regulated kinase 5 (ERK5), on specific threonine and tyrosine residues. MKK5 is activated by MEKK2 and MEKK3 in response to mitogenic and stress stimuli. The ERK5 cascade promotes cell proliferation, differentiation, neuronal survival, and neuroprotection. This cascade plays an essential role in heart development. Mice deficient in either ERK5 or MKK5 die around embryonic day 10 due to cardiovascular defects including underdevelopment of the myocardium. In addition, MKK5 is associated with metastasis and unfavorable prognosis in prostate cancer. The MKK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132950 [Multi-domain]  Cd Length: 279  Bit Score: 84.54  E-value: 3.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 259 IILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAIsdSGQSFSGKAlDVWA 338
Cdd:cd06619   104 VVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPERI--SGEQYGIHS-DVWS 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 339 TGVTLYCFVYGKCPFIDDYiltlhrkiKNEAVVFP---------EEPEV------SEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd06619   179 LGISFMELALGRFPYPQIQ--------KNQGSLMPlqllqcivdEDPPVlpvgqfSEKFVHFITQCMRKQPKERPAPENL 250

                  ....*.
gi 1384865967 404 KLHPWV 409
Cdd:cd06619   251 MDHPFI 256
STKc_MLK2 cd14148
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the ...
194-403 3.77e-18

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK2 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K10. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK2 is abundant in brain, skeletal muscle, and testis. It functions upstream of the MAPK, c-Jun N-terminal kinase. It binds hippocalcin, a calcium-sensor protein that protects neurons against calcium-induced cell death. Both MLK2 and hippocalcin may be associated with the pathogenesis of Parkinson's disease. MLK2 also binds to normal huntingtin (Htt), which is important in neuronal transcription, development, and survival. MLK2 does not bind to the polyglutamine-expanded Htt, which is implicated in the pathogeneis of Huntington's disease, leading to neuronal toxicity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271050 [Multi-domain]  Cd Length: 258  Bit Score: 84.27  E-value: 3.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEV-LDDPaedNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd14148    38 ENVRQEARLFWMLQHPNIIALRGVcLNPP---HLCLVMEYARGGALNRALAGKKVPPHVLVNWAVQIARGMNYLHNEAIV 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 ---HRDIKPSNLLLGD--------DGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAISdsgQSFSGKALDVWATGV 341
Cdd:cd14148   115 piiHRDLKSSNILILEpienddlsGKTLKITDFGLAREWHKTTKM--SAAGTYAWMAPEVIR---LSLFSKSSDVWSFGV 189
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 342 TLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd14148   190 LLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSI 251
PTKc_Ack_like cd05040
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs ...
198-404 3.98e-18

Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes Ack1, thirty-eight-negative kinase 1 (Tnk1), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal catalytic domain, an SH3 domain, a Cdc42-binding CRIB domain, and a proline-rich region. They are mainly expressed in brain and skeletal tissues and are involved in the regulation of cell adhesion and growth, receptor degradation, and axonal guidance. Ack1 is also associated with androgen-independent prostate cancer progression. Tnk1 regulates TNFalpha signaling and may play an important role in cell death. The Ack-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270636 [Multi-domain]  Cd Length: 258  Bit Score: 83.93  E-value: 3.98e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIE-VLDDPaednLYLVFDLLRKGPVME-VPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd05040    47 KEVNAMHSLDHPNLIRLYGvVLSSP----LMMVTELAPLGSLLDrLRKDQGhFLISTLCDYAVQIANGMAYLESKRFIHR 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG--TP-AFMAPEAISDsgQSFSgKALDVWATGVTLY-CFVYGK 350
Cdd:cd05040   123 DLAARNILLASKDKVKIGDFGLMRALPQNEDHYVMQEHrkVPfAWCAPESLKT--RKFS-HASDVWMFGVTLWeMFTYGE 199
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 351 CPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIK 404
Cdd:cd05040   200 EPWLGLNGSQILEKIDKEGERLERPDDCPQDIYNVMLQCWAHKPADRPTFVALR 253
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
205-397 4.13e-18

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 87.16  E-value: 4.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKlieVLDDPAEDNL-YLVF---------DLLRKGpvmevpcdKPFPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:NF033483   63 SLSHPNIVS---VYDVGEDGGIpYIVMeyvdgrtlkDYIREH--------GPLSPEEAVEIMIQILSALEHAHRNGIVHR 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFG----VSNQfegNDAQLSSTAGTPAFMAPEAISDS---GQSfsgkalDVWATGVTLYCFV 347
Cdd:NF033483  132 DIKPQNILITKDGRVKVTDFGiaraLSST---TMTQTNSVLGTVHYLSPEQARGGtvdARS------DIYSLGIVLYEML 202
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 348 YGKCPFIDDYILTLHRKIKNEAVVFPEE--PEVSEDLKDLILRMLDKNPETR 397
Cdd:NF033483  203 TGRPPFDGDSPVSVAYKHVQEDPPPPSElnPGIPQSLDAVVLKATAKDPDDR 254
PTKc_Fer cd05085
Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; ...
188-404 5.61e-18

Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; Fer kinase; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fer kinase is a member of the Fes subfamily of proteins which are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. Fer kinase is expressed in a wide variety of tissues, and is found to reside in both the cytoplasm and the nucleus. It plays important roles in neuronal polarization and neurite development, cytoskeletal reorganization, cell migration, growth factor signaling, and the regulation of cell-cell interactions mediated by adherens junctions and focal adhesions. Fer kinase also regulates cell cycle progression in malignant cells.


Pssm-ID: 270668 [Multi-domain]  Cd Length: 251  Bit Score: 83.52  E-value: 5.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 188 KQLLPLE---RVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKP--FPEEQARLYLRDIILG 262
Cdd:cd05085    29 KEDLPQElkiKFLSEARILKQYDHPNIVKLIGVCTQ--RQPIYIVMELVPGGDFLSFLRKKKdeLKTKQLVKFSLDAAAG 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAIsDSGQsFSGKAlDVWATGV 341
Cdd:cd05085   107 MAYLESKNCIHRDLAARNCLVGENNALKISDFGMSRQEDDGVYSSSGLKQIPiKWTAPEAL-NYGR-YSSES-DVWSFGI 183
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 342 TLY-CFVYGKCPFIDDYILTLHRKI-KNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIK 404
Cdd:cd05085   184 LLWeTFSLGVCPYPGMTNQQAREQVeKGYRMSAPQ--RCPEDIYKIMQRCWDYNPENRPKFSELQ 246
STKc_CDKL1_4 cd07847
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; ...
199-340 6.05e-18

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL1, also called p42 KKIALRE, is a glial protein that is upregulated in gliosis. It is present in neuroblastoma and A431 human carcinoma cells, and may be implicated in neoplastic transformation. The function of CDKL4 is unknown. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL1/4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270837 [Multi-domain]  Cd Length: 286  Bit Score: 83.96  E-value: 6.05e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDL--------LRKGPvmevpcdKPFPEEQARLYLRDIILGLEYLHCQK 270
Cdd:cd07847    50 EIRMLKQLKHPNLVNLIEVFR--RKRKLHLVFEYcdhtvlneLEKNP-------RGVPEHLIKKIIWQTLQAVNFCHKHN 120
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATG 340
Cdd:cd07847   121 CIHRDVKPENILITKQGQIKLCDFGFARILTGPGDDYTDYVATRWYRAPELL--VGDTQYGPPVDVWAIG 188
PTKc_Csk_like cd05039
Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
123-353 7.64e-18

Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of Csk, Chk, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. They negatively regulate the activity of Src kinases that are anchored to the plasma membrane. To inhibit Src kinases, Csk and Chk are translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Chk inhibit Src kinases using a noncatalytic mechanism by simply binding to them. As negative regulators of Src kinases, Csk and Chk play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. The Csk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270635 [Multi-domain]  Cd Length: 256  Bit Score: 83.17  E-value: 7.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 123 VQLNQYKLQSEIGKGAYGVVRLAynESEDRHYAMKVLSKkkllkqygfprrppprgsqatQGGPAKQLLplervyQEIAI 202
Cdd:cd05039     3 INKKDLKLGELIGKGEFGDVMLG--DYRGQKVAVKCLKD---------------------DSTAAQAFL------AEASV 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 203 LKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEvpcdkpfpeeqarlYLR-----------------DIILGLEY 265
Cdd:cd05039    54 MTTLRHPNLVQLLGVVLE--GNGLYIVTEYMAKGSLVD--------------YLRsrgravitrkdqlgfalDVCEGMEY 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSnqfegNDAQLSSTAGT-P-AFMAPEAISDSgqSFSGKAlDVWATGVTL 343
Cdd:cd05039   118 LESKKFVHRDLAARNVLVSEDNVAKVSDFGLA-----KEASSNQDGGKlPiKWTAPEALREK--KFSTKS-DVWSFGILL 189
                         250
                  ....*....|.
gi 1384865967 344 Y-CFVYGKCPF 353
Cdd:cd05039   190 WeIYSFGRVPY 200
STKc_CDKL5 cd07848
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs ...
194-343 7.90e-18

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mutations in the gene encoding CDKL5, previously called STK9, are associated with early onset epilepsy and severe mental retardation [X-linked infantile spasm syndrome (ISSX) or West syndrome]. In addition, CDKL5 mutations also sometimes cause a phenotype similar to Rett syndrome (RTT), a progressive neurodevelopmental disorder. These pathogenic mutations are located in the N-terminal portion of the protein within the kinase domain. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270838 [Multi-domain]  Cd Length: 287  Bit Score: 83.89  E-value: 7.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGpVMEVPCDKP--FPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd07848    45 ETTLRELKMLRTLKQENIVELKEAFRRRGK--LYLVFEYVEKN-MLELLEEMPngVPPEKVRSYIYQLIKAIHWCHKNDI 121
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGVS-NQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFsGKALDVWATGVTL 343
Cdd:cd07848   122 VHRDIKPENLLISHNDVLKLCDFGFArNLSEGSNANYTEYVATRWYRSPELL--LGAPY-GKAVDMWSVGCIL 191
STKc_p38delta cd07879
Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase ...
194-408 1.00e-17

Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38delta/MAPK13 is found in skeletal muscle, heart, lung, testis, pancreas, and small intestine. It regulates microtubule function by phosphorylating Tau. It activates the c-jun promoter and plays a role in G2 cell cycle arrest. It also controls the degration of c-Myb, which is associated with myeloid leukemia and poor prognosis in colorectal cancer. p38delta is the main isoform involved in regulating the differentiation and apoptosis of keratinocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143384 [Multi-domain]  Cd Length: 342  Bit Score: 84.57  E-value: 1.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAE----DNLYLVFdllrkgPVMEVPCDK----PFPEEQARLYLRDIILGLEY 265
Cdd:cd07879    59 KRAYRELTLLKHMQHENVIGLLDVFTSAVSgdefQDFYLVM------PYMQTDLQKimghPLSEDKVQYLVYQMLCGLKY 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQfegNDAQLSSTAGTPAFMAPEAISDsgQSFSGKALDVWATGVTLYC 345
Cdd:cd07879   133 IHSAGIIHRDLKPGNLAVNEDCELKILDFGLARH---ADAEMTGYVVTRWYRAPEVILN--WMHYNQTVDIWSVGCIMAE 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 346 FVYGKCPFI-DDYILTLHRKIKNEAVVFPE----------------------------EPEVSEDLKDLILRMLDKNPET 396
Cdd:cd07879   208 MLTGKTLFKgKDYLDQLTQILKVTGVPGPEfvqkledkaaksyikslpkyprkdfstlFPKASPQAVDLLEKMLELDVDK 287
                         250
                  ....*....|..
gi 1384865967 397 RIGVSDIKLHPW 408
Cdd:cd07879   288 RLTATEALEHPY 299
PTKc_Srm_Brk cd05148
Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal ...
190-353 1.08e-17

Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk); PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Srm and Brk (also called protein tyrosine kinase 6) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Brk has been found to be overexpressed in a majority of breast tumors. Src kinases in general contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr; they are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Srm and Brk however, lack the N-terminal myristylation sites. Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. The Srm/Brk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133248 [Multi-domain]  Cd Length: 261  Bit Score: 82.87  E-value: 1.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 190 LLPLERVYQEIAILKKLDHVNVVKLIEV--LDDPaednLYLVFDLLRKGPVMEVPCDkpfPEEQArLYLRDIIL------ 261
Cdd:cd05148    43 LLKQQDFQKEVQALKRLRHKHLISLFAVcsVGEP----VYIITELMEKGSLLAFLRS---PEGQV-LPVASLIDmacqva 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 -GLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEgNDAQLSSTAGTP-AFMAPEAISDsgQSFSGKAlDVWAT 339
Cdd:cd05148   115 eGMAYLEEQNSIHRDLAARNILVGEDLVCKVADFGLARLIK-EDVYLSSDKKIPyKWTAPEAASH--GTFSTKS-DVWSF 190
                         170
                  ....*....|....*
gi 1384865967 340 GVTLY-CFVYGKCPF 353
Cdd:cd05148   191 GILLYeMFTYGQVPY 205
PK_eIF2AK_GCN2_rpt1 cd14012
Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or ...
188-407 1.19e-17

Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: GCN2, protein kinase regulated by RNA (PKR), heme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK). GCN2 is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kappaB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. The degenerate pseudokinase domain of GCN2 may function as a regulatory domain. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270914 [Multi-domain]  Cd Length: 254  Bit Score: 82.41  E-value: 1.19e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 188 KQLLPLERvyqEIAILKKLDHVNVVKLIEVLDDPAEDN----LYLVFDLLRKGPVME----VPcdkPFPEEQARLYLRDI 259
Cdd:cd14012    40 KQIQLLEK---ELESLKKLRHPNLVSYLAFSIERRGRSdgwkVYLLTEYAPGGSLSElldsVG---SVPLDTARRWTLQL 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 260 ILGLEYLHCQKIVHRDIKPSNLLLGDDGH---VKIADFGVSNQFEGNDAQLSSTAGTPAF-MAPEaisDSGQSFS-GKAL 334
Cdd:cd14012   114 LEALEYLHRNGVVHKSLHAGNVLLDRDAGtgiVKLTDYSLGKTLLDMCSRGSLDEFKQTYwLPPE---LAQGSKSpTRKT 190
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 335 DVWATGVTLYCFVYGKCPFIddYILTLHrkikneavVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd14012   191 DVWDLGLLFLQMLFGLDVLE--KYTSPN--------PVLVSLDLSASLQDFLSKCLSLDPKKRPTALELLPHE 253
STKc_IKK cd13989
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
194-366 1.63e-17

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The IKK complex functions as a master regulator of Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. It is composed of two kinases, IKKalpha and IKKbeta, and the regulatory subunit IKKgamma or NEMO (NF-kB Essential MOdulator). IKKs facilitate the release of NF-kB dimers from an inactive state, allowing them to migrate to the nucleus where they regulate gene transcription. There are two IKK pathways that regulate NF-kB signaling, called the classical (involving IKKbeta and NEMO) and non-canonical (involving IKKalpha) pathways. The classical pathway regulates the majority of genes activated by NF-kB. The IKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270891 [Multi-domain]  Cd Length: 289  Bit Score: 82.88  E-value: 1.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEV---LDDPAEDNL-YLVFDLLRKGPVMEVpCDKP-----FPEEQARLYLRDIILGLE 264
Cdd:cd13989    38 ERWCLEVQIMKKLNHPNVVSARDVppeLEKLSPNDLpLLAMEYCSGGDLRKV-LNQPenccgLKESEVRTLLSDISSAIS 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 265 YLHCQKIVHRDIKPSNLLL---GDDGHVKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAISDSGQSFSgkaLDVWATGV 341
Cdd:cd13989   117 YLHENRIIHRDLKPENIVLqqgGGRVIYKLIDLGYAKELD-QGSLCTSFVGTLQYLAPELFESKKYTCT---VDYWSFGT 192
                         170       180
                  ....*....|....*....|....*.
gi 1384865967 342 TLYCFVYGKCPFIDDYI-LTLHRKIK 366
Cdd:cd13989   193 LAFECITGYRPFLPNWQpVQWHGKVK 218
STKc_JNK cd07850
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the ...
127-410 1.63e-17

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. They are also essential regulators of physiological and pathological processes and are involved in the pathogenesis of several diseases such as diabetes, atherosclerosis, stroke, Parkinson's and Alzheimer's. Vetebrates harbor three different JNK genes (Jnk1, Jnk2, and Jnk3) that are alternatively spliced to produce at least 10 isoforms. JNKs are specifically activated by the MAPK kinases MKK4 and MKK7, which are in turn activated by upstream MAPK kinase kinases as a result of different stimuli including stresses such as ultraviolet (UV) irradiation, hyperosmolarity, heat shock, or cytokines. JNKs activate a large number of different substrates based on specific stimulus, cell type, and cellular condition, and may be implicated in seemingly contradictory functions. The JNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270840 [Multi-domain]  Cd Length: 337  Bit Score: 83.62  E-value: 1.63e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygfprRPPPRGSQAtqggpakqllplERVYQEIAILKKL 206
Cdd:cd07850     1 RYQNLKPIGSGAQGIVCAAYDTVTGQNVAIKKLS------------RPFQNVTHA------------KRAYRELVLMKLV 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEV------LDDPAEdnLYLVFDLLRKG--PVMEVPCDkpfpEEQARLYLRDIILGLEYLHCQKIVHRDIKP 278
Cdd:cd07850    57 NHKNIIGLLNVftpqksLEEFQD--VYLVMELMDANlcQVIQMDLD----HERMSYLLYQMLCGIKHLHSAGIIHRDLKP 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 279 SNLLLGDDGHVKIADFGvsnqfegndaqLSSTAGTpAFM-----------APEAISDSGQSfsgKALDVWATGVTLYCFV 347
Cdd:cd07850   131 SNIVVKSDCTLKILDFG-----------LARTAGT-SFMmtpyvvtryyrAPEVILGMGYK---ENVDIWSVGCIMGEMI 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 348 YGKCPF-----ID--------------DYILTLHRKIKNEA-----------------VVFPEEPEVSEDLK-----DLI 386
Cdd:cd07850   196 RGTVLFpgtdhIDqwnkiieqlgtpsdEFMSRLQPTVRNYVenrpkyagysfeelfpdVLFPPDSEEHNKLKasqarDLL 275
                         330       340
                  ....*....|....*....|....
gi 1384865967 387 LRMLDKNPETRIGVSDIKLHPWVT 410
Cdd:cd07850   276 SKMLVIDPEKRISVDDALQHPYIN 299
STKc_TAK1 cd14058
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated ...
199-403 1.64e-17

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAK1 is also known as mitogen-activated protein kinase kinase kinase 7 (MAPKKK7 or MAP3K7), TAK, or MEKK7. As a MAPKKK, it is an important mediator of cellular responses to extracellular signals. It regulates both the c-Jun N-terminal kinase and p38 MAPK cascades by activating the MAPK kinases, MKK4 and MKK3/6. In addition, TAK1 plays diverse roles in immunity and development, in different biological contexts, through many signaling pathways including TGFbeta/BMP, Wnt/Fz, and NF-kB. It is also implicated in the activation of the tumor suppressor kinase, LKB1. The TAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270960 [Multi-domain]  Cd Length: 253  Bit Score: 82.10  E-value: 1.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPAEDnlYLVFDLLRKGPVMEV-PCDKPFPE---EQARLYLRDIILGLEYLHCQK---I 271
Cdd:cd14058    36 EVRQLSRVDHPNIIKLYGACSNQKPV--CLVMEYAEGGSLYNVlHGKEPKPIytaAHAMSWALQCAKGVAYLHSMKpkaL 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHV-KIADFGVSNQFEgndAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLYCFVYGK 350
Cdd:cd14058   114 IHRDLKPPNLLLTNGGTVlKICDFGTACDIS---THMTNNKGSAAWMAPEVF--EGSKYSEKC-DVFSWGIILWEVITRR 187
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 351 CPFiDD-------YILTLHRKIKneavvFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd14058   188 KPF-DHiggpafrIMWAVHNGER-----PPLIKNCPKPIESLMTRCWSKDPEKRPSMKEI 241
STKc_IKK_alpha cd14039
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
194-368 2.18e-17

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKalpha is involved in the non-canonical or alternative pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The non-canonical pathway functions in cells lacking NEMO (NF-kB Essential MOdulator) and IKKbeta. It is induced by a subset of TNFR family members including CD40, RANK, and B cell-activating factor receptor. IKKalpha processes the Inhibitor of NF-kB (IkB)-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus. This pathway is dependent on NIK (NF-kB Inducing Kinase) which phosphorylates and activates IKKalpha. The IKKalpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270941 [Multi-domain]  Cd Length: 289  Bit Score: 82.66  E-value: 2.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEV---LDDPAEDNLYLVFDLLRKGPVMEVpCDKP-----FPEEQARLYLRDIILGLEY 265
Cdd:cd14039    36 DRWCHEIQIMKKLNHPNVVKACDVpeeMNFLVNDVPLLAMEYCSGGDLRKL-LNKPenccgLKESQVLSLLSDIGSGIQY 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDG----HvKIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAIsdSGQSFSgKALDVWATGV 341
Cdd:cd14039   115 LHENKIIHRDLKPENIVLQEINgkivH-KIIDLGYAKDLD-QGSLCTSFVGTLQYLAPELF--ENKSYT-VTVDYWSFGT 189
                         170       180
                  ....*....|....*....|....*...
gi 1384865967 342 TLYCFVYGKCPFIDDY-ILTLHRKIKNE 368
Cdd:cd14039   190 MVFECIAGFRPFLHNLqPFTWHEKIKKK 217
STKc_GRK2 cd14223
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs ...
224-399 2.51e-17

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK2, also called beta-adrenergic receptor kinase (beta-ARK) or beta-ARK1, is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRK2 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. TheGRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271125 [Multi-domain]  Cd Length: 321  Bit Score: 82.79  E-value: 2.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 224 DNLYLVFDLLRKGPV-MEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG 302
Cdd:cd14223    76 DKLSFILDLMNGGDLhYHLSQHGVFSEAEMRFYAAEIILGLEHMHSRFVVYRDLKPANILLDEFGHVRISDLGLACDFSK 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 303 NDAQlsSTAGTPAFMAPEAISdSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLH---RKIKNEAVVFPEepEVS 379
Cdd:cd14223   156 KKPH--ASVGTHGYMAPEVLQ-KGVAYDSSA-DWFSLGCMLFKLLRGHSPFRQHKTKDKHeidRMTLTMAVELPD--SFS 229
                         170       180
                  ....*....|....*....|
gi 1384865967 380 EDLKDLILRMLDKNPETRIG 399
Cdd:cd14223   230 PELRSLLEGLLQRDVNRRLG 249
PTKc_Tyk2_rpt2 cd05080
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze ...
198-344 2.61e-17

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyk2 is widely expressed in many tissues. It is involved in signaling via the cytokine receptors IFN-alphabeta, IL-6, IL-10, IL-12, IL-13, and IL-23. It mediates cell surface urokinase receptor (uPAR) signaling and plays a role in modulating vascular smooth muscle cell (VSMC) functional behavior in response to injury. Tyk2 is also important in dendritic cell function and T helper (Th)1 cell differentiation. A homozygous mutation of Tyk2 was found in a patient with hyper-IgE syndrome (HIES), a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and elevated serum IgE. This suggests that Tyk2 may play important roles in multiple cytokine signaling involved in innate and adaptive immunity. Tyk2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Tyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270664 [Multi-domain]  Cd Length: 283  Bit Score: 82.25  E-value: 2.61e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd05080    55 QEIDILKTLYHENIVKYKGCCSEQGGKSLQLIMEYVPLGSLRDYLPKHSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLA 134
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 278 PSNLLLGDDGHVKIADFGVSNQF-EGND-AQLSSTAGTPAF-MAPEAISDSGQSFsgkALDVWATGVTLY 344
Cdd:cd05080   135 ARNVLLDNDRLVKIGDFGLAKAVpEGHEyYRVREDGDSPVFwYAPECLKEYKFYY---ASDVWSFGVTLY 201
STKc_JNK3 cd07874
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the ...
112-409 2.75e-17

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK3 is expressed primarily in the brain, and to a lesser extent in the heart and testis. Mice deficient in JNK3 are protected against kainic acid-induced seizures, stroke, sciatic axotomy neural death, and neuronal death due to NGF deprivation, oxidative stress, or exposure to beta-amyloid peptide. This suggests that JNK3 may play roles in the pathogenesis of these diseases. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143379 [Multi-domain]  Cd Length: 355  Bit Score: 83.21  E-value: 2.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 112 HRVAISDTEDCVqLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygfprRPPPRGSQAtqggpakqll 191
Cdd:cd07874     4 YSVEVGDSTFTV-LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLS------------RPFQNQTHA---------- 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 192 plERVYQEIAILKKLDHVNVVKLIEVLDDPAE----DNLYLVFDLLRKG--PVMEVPCDkpfpEEQARLYLRDIILGLEY 265
Cdd:cd07874    61 --KRAYRELVLMKCVNHKNIISLLNVFTPQKSleefQDVYLVMELMDANlcQVIQMELD----HERMSYLLYQMLCGIKH 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYC 345
Cdd:cd07874   135 LHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMGYK---ENVDIWSVGCIMGE 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 346 FVYGK----------------------CP-FIDDYILTLHRKIKNEA-------------VVFPEEPE----VSEDLKDL 385
Cdd:cd07874   211 MVRHKilfpgrdyidqwnkvieqlgtpCPeFMKKLQPTVRNYVENRPkyagltfpklfpdSLFPADSEhnklKASQARDL 290
                         330       340
                  ....*....|....*....|....
gi 1384865967 386 ILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd07874   291 LSKMLVIDPAKRISVDEALQHPYI 314
STKc_Raf cd14062
Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) ...
199-353 3.28e-17

Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Raf kinases act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. Aberrant expression or activation of components in this pathway are associated with tumor initiation, progression, and metastasis. Raf proteins contain a Ras binding domain, a zinc finger cysteine-rich domain, and a catalytic kinase domain. Vertebrates have three Raf isoforms (A-, B-, and C-Raf) with different expression profiles, modes of regulation, and abilities to function in the ERK cascade, depending on cellular context and stimuli. They have essential and non-overlapping roles during embryo- and organogenesis. Knockout of each isoform results in a lethal phenotype or abnormality in most mouse strains. The Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270964 [Multi-domain]  Cd Length: 253  Bit Score: 81.29  E-value: 3.28e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPaedNLYLVFD------LLRKGPVMEVPcdkpFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd14062    39 EVAVLRKTRHVNILLFMGYMTKP---QLAIVTQwcegssLYKHLHVLETK----FEMLQLIDIARQTAQGMDYLHAKNII 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFG---VSNQFEGNDaQLSSTAGTPAFMAPEAISDSGQS-FSGKAlDVWATGVTLYCFVY 348
Cdd:cd14062   112 HRDLKSNNIFLHEDLTVKIGDFGlatVKTRWSGSQ-QFEQPTGSILWMAPEVIRMQDENpYSFQS-DVYAFGIVLYELLT 189

                  ....*
gi 1384865967 349 GKCPF 353
Cdd:cd14062   190 GQLPY 194
STKc_PIM1 cd14100
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
195-409 3.82e-17

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 isoforms resulting from alternative translation initiation sites. PIM1 is the founding member of the PIM subfamily. It is involved in regulating cell growth, differentiation, and apoptosis. It promotes cancer development when overexpressed by inhibiting apoptosis, promoting cell proliferation, and promoting genomic instability. The PIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271002 [Multi-domain]  Cd Length: 254  Bit Score: 81.17  E-value: 3.82e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 195 RVYQEIAILKKLDH--VNVVKLIEVLDDPaeDNLYLVFDllRKGPVME----VPCDKPFPEEQARLYLRDIILGLEYLHC 268
Cdd:cd14100    49 RVPMEIVLLKKVGSgfRGVIRLLDWFERP--DSFVLVLE--RPEPVQDlfdfITERGALPEELARSFFRQVLEAVRHCHN 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 269 QKIVHRDIKPSNLLLG-DDGHVKIADFGVSNQFEgnDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFV 347
Cdd:cd14100   125 CGVLHRDIKDENILIDlNTGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWI--RFHRYHGRSAAVWSLGILLYDMV 200
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 348 YGKCPFIDDyiltlhRKIKNEAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14100   201 CGDIPFEHD------EEIIRGQVFFRQ--RVSSECQHLIKWCLALRPSDRPSFEDIQNHPWM 254
STKc_PCTAIRE1 cd07873
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer ...
198-414 5.14e-17

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-1 is expressed ubiquitously and is localized in the cytoplasm. Its kinase activity is cell cycle dependent and peaks at the S and G2 phases. PCTAIRE-1 is highly expressed in the brain and may play a role in regulating neurite outgrowth. It can also associate with Trap (Tudor repeat associator with PCTAIRE-2), a physiological partner of PCTAIRE-2; with p11, a small dimeric protein with similarity to S100; and with 14-3-3 proteins, mediators of phosphorylation-dependent interactions in many different proteins. PCTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270854 [Multi-domain]  Cd Length: 297  Bit Score: 81.59  E-value: 5.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVP-CDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd07873    49 REVSLLKDLKHANIVTLHDIIH--TEKSLTLVFEYLDKDLKQYLDdCGNSINMHNVKLFLFQLLRGLAYCHRRKVLHRDL 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPF--- 353
Cdd:cd07873   127 KPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL--LGSTDYSTQIDMWGVGCIFYEMSTGRPLFpgs 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 354 -IDDYILTLHRKI------------KNEAVV---FPE---------EPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd07873   205 tVEEQLHFIFRILgtpteetwpgilSNEEFKsynYPKyradalhnhAPRLDSDGADLLSKLLQFEGRKRISAEEAMKHPY 284

                  ....*.
gi 1384865967 409 VTKHGE 414
Cdd:cd07873   285 FHSLGE 290
PTKc_Frk_like cd05068
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
198-353 8.69e-17

Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Frk and Srk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Frk, also known as Rak, is specifically expressed in liver, lung, kidney, intestine, mammary glands, and the islets of Langerhans. Rodent homologs were previously referred to as GTK (gastrointestinal tyr kinase), BSK (beta-cell Src-like kinase), or IYK (intestinal tyr kinase). Studies in mice reveal that Frk is not essential for viability. It plays a role in the signaling that leads to cytokine-induced beta-cell death in Type I diabetes. It also regulates beta-cell number during embryogenesis and early in life. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Frk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270653 [Multi-domain]  Cd Length: 267  Bit Score: 80.14  E-value: 8.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEV--LDDPaednLYLVFDLLRKGPVMEvpcdkpFPEEQAR-LYLRDII-------LGLEYLH 267
Cdd:cd05068    52 REAQIMKKLRHPKLIQLYAVctLEEP----IYIITELMKHGSLLE------YLQGKGRsLQLPQLIdmaaqvaSGMAYLE 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 268 CQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDaQLSSTAGTP---AFMAPEAISDSgqSFSGKAlDVWATGVTLY 344
Cdd:cd05068   122 SQNYIHRDLAARNVLVGENNICKVADFGLARVIKVED-EYEAREGAKfpiKWTAPEAANYN--RFSIKS-DVWSFGILLT 197
                         170
                  ....*....|
gi 1384865967 345 CFV-YGKCPF 353
Cdd:cd05068   198 EIVtYGRIPY 207
STKc_MLK4 cd14146
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the ...
194-353 9.72e-17

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK4 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The specific function of MLK4 is yet to be determined. Mutations in the kinase domain of MLK4 have been detected in colorectal cancers. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271048 [Multi-domain]  Cd Length: 268  Bit Score: 80.08  E-value: 9.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEV-LDDPaedNLYLVFDLLRKGPV---MEVPCDKPFPEEQARL-------YLRDIILG 262
Cdd:cd14146    38 ESVRQEAKLFSMLRHPNIIKLEGVcLEEP---NLCLVMEFARGGTLnraLAAANAAPGPRRARRIpphilvnWAVQIARG 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYLHCQKIV---HRDIKPSNLLL-----GDD---GHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAISDSgqSFSg 331
Cdd:cd14146   115 MLYLHEEAVVpilHRDLKSSNILLlekieHDDicnKTLKITDFGLAREWHRTTKM--SAAGTYAWMAPEVIKSS--LFS- 189
                         170       180
                  ....*....|....*....|..
gi 1384865967 332 KALDVWATGVTLYCFVYGKCPF 353
Cdd:cd14146   190 KGSDIWSYGVLLWELLTGEVPY 211
PTKc_Chk cd05083
Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the ...
199-353 9.85e-17

Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Chk is also referred to as megakaryocyte-associated tyrosine kinase (Matk). Chk inhibits Src kinases using a noncatalytic mechanism by simply binding to them. As a negative regulator of Src kinases, Chk may play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Chk is expressed in brain and hematopoietic cells. Like Csk, it is a cytoplasmic (or nonreceptor) tyr kinase containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases that are anchored to the plasma membrane, Chk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Studies in mice reveal that Chk is not functionally redundant with Csk and that it plays an important role as a regulator of immune responses. Chk also plays a role in neural differentiation in a manner independent of Src by enhancing Mapk activation via Ras-mediated signaling. The Chk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270666 [Multi-domain]  Cd Length: 254  Bit Score: 79.92  E-value: 9.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLddpAEDNLYLVFDLLRKGPVMEVPCDK---PFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd05083    49 ETAVMTKLQHKNLVRLLGVI---LHNGLYIVMELMSKGNLVNFLRSRgraLVPVIQLLQFSLDVAEGMEYLESKKLVHRD 125
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 276 IKPSNLLLGDDGHVKIADFGVSnqfEGNDAQLSSTAGTPAFMAPEAISDsgQSFSGKAlDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05083   126 LAARNILVSEDGVAKISDFGLA---KVGSMGVDNSRLPVKWTAPEALKN--KKFSSKS-DVWSYGVLLWeVFSYGRAPY 198
STKc_JNK2 cd07876
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the ...
194-410 1.26e-16

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK2 is expressed in every cell and tissue type. It is specifically translocated to the mitochondria during dopaminergic cell death. Specific substrates include the microtubule-associated proteins DCX and Tau, as well as TIF-IA which is involved in ribosomal RNA synthesis regulation. Mice deficient in Jnk2 show protection against arthritis, type 1 diabetes, atherosclerosis, abdominal aortic aneurysm, cardiac cell death, TNF-induced liver damage, and tumor growth, indicating that JNK2 may play roles in the pathogenesis of these diseases. Initially it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143381 [Multi-domain]  Cd Length: 359  Bit Score: 81.23  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAE----DNLYLVFDLLRKGPVMEVPCDkpFPEEQARLYLRDIILGLEYLHCQ 269
Cdd:cd07876    65 KRAYRELVLLKCVNHKNIISLLNVFTPQKSleefQDVYLVMELMDANLCQVIHME--LDHERMSYLLYQMLCGIKHLHSA 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 270 KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNdAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYG 349
Cdd:cd07876   143 GIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN-FMMTPYVVTRYYRAPEVILGMGYK---ENVDIWSVGCIMGELVKG 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 350 KCPF-----ID--------------DYILTLHRKIKNEAV-----------------VFPEEPE----VSEDLKDLILRM 389
Cdd:cd07876   219 SVIFqgtdhIDqwnkvieqlgtpsaEFMNRLQPTVRNYVEnrpqypgisfeelfpdwIFPSESErdklKTSQARDLLSKM 298
                         250       260
                  ....*....|....*....|.
gi 1384865967 390 LDKNPETRIGVSDIKLHPWVT 410
Cdd:cd07876   299 LVIDPDKRISVDEALRHPYIT 319
PKc_DYRK_like cd14133
Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like ...
199-409 1.76e-16

Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like protein kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity DYRKs and YAK1, as well as the S/T kinases (STKs), HIPKs. DYRKs and YAK1 autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. Proteins in this subfamily play important roles in cell proliferation, differentiation, survival, growth, and development. The DYRK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271035 [Multi-domain]  Cd Length: 262  Bit Score: 79.23  E-value: 1.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKL------DHVNVVKLIEVLddPAEDNLYLVFDLLRKG--PVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQK 270
Cdd:cd14133    45 EIRLLELLnkkdkaDKYHIVRLKDVF--YFKNHLCIVFELLSQNlyEFLKQNKFQYLSLPRIRKIAQQILEALVFLHSLG 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLG--DDGHVKIADFGvSNQFEGNdaQLSSTAGTPAFMAPEAIsdSGQSFSGKaLDVWATGVTLYCFVY 348
Cdd:cd14133   123 LIHCDLKPENILLAsySRCQIKIIDFG-SSCFLTQ--RLYSYIQSRYYRAPEVI--LGLPYDEK-IDMWSLGCILAELYT 196
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 349 GKCPFIDDYILTLHRKIKNEAVVFPEE-----PEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14133   197 GEPLFPGASEVDQLARIIGTIGIPPAHmldqgKADDELFVDFLKKLLEIDPKERPTASQALSHPWL 262
STKc_p38gamma cd07880
Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase ...
186-353 2.10e-16

Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38gamma/MAPK12 is predominantly expressed in skeletal muscle. Unlike p38alpha and p38beta, p38gamma is insensitive to pyridinylimidazoles. It displays an antagonizing function compared to p38alpha. p38gamma inhibits, while p38alpha stimulates, c-Jun phosphorylation and AP-1 mediated transcription. p38gamma also plays a role in the signaling between Ras and the estrogen receptor and has been implicated to increase cell invasion and breast cancer progression. In Xenopus, p38gamma is critical in the meiotic maturation of oocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143385 [Multi-domain]  Cd Length: 343  Bit Score: 80.38  E-value: 2.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 186 PAKQLLPLERVYQEIAILKKLDHVNVVKLIEVL--DDPAED--NLYLVFDLLRK--GPVMEVpcdKPFPEEQARLYLRDI 259
Cdd:cd07880    51 PFQSELFAKRAYRELRLLKHMKHENVIGLLDVFtpDLSLDRfhDFYLVMPFMGTdlGKLMKH---EKLSEDRIQFLVYQM 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 260 ILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQfegNDAQLSSTAGTPAFMAPEAISdSGQSFSgKALDVWAT 339
Cdd:cd07880   128 LKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ---TDSEMTGYVVTRWYRAPEVIL-NWMHYT-QTVDIWSV 202
                         170
                  ....*....|....
gi 1384865967 340 GVTLYCFVYGKCPF 353
Cdd:cd07880   203 GCIMAEMLTGKPLF 216
STKc_IRAK cd14066
Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases ...
194-400 2.29e-16

Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. Some IRAKs may also play roles in T- and B-cell signaling, and adaptive immunity. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK-1, -2, and -4 are ubiquitously expressed and are active kinases, while IRAK-M is only induced in monocytes and macrophages and is an inactive kinase. Variations in IRAK genes are linked to diverse diseases including infection, sepsis, cancer, and autoimmune diseases. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase domain in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. This subfamily includes plant receptor-like kinases (RLKs) including Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1). BAK1 functions in BR (brassinosteroid)-regulated plant development and in pathways involved in plant resistance to pathogen infection and herbivore attack. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The IRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270968 [Multi-domain]  Cd Length: 272  Bit Score: 79.24  E-value: 2.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEV----PCDKPFPEEQaRLylrDIILG----LEY 265
Cdd:cd14066    35 KEFLTELEMLGRLRHPNLVRLLGYCLES--DEKLLVYEYMPNGSLEDRlhchKGSPPLPWPQ-RL---KIAKGiargLEY 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LH--CQ-KIVHRDIKPSNLLLGDDGHVKIADFGVSN--QFEGNDAQLSSTAGTPAFMAPEAISdSGQsFSGKAlDVWATG 340
Cdd:cd14066   109 LHeeCPpPIIHGDIKSSNILLDEDFEPKLTDFGLARliPPSESVSKTSAVKGTIGYLAPEYIR-TGR-VSTKS-DVYSFG 185
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 341 VTLYCFVYGKCPFIDDYILTLHRKIKNEAvvfpeEPEVSEDLKDLILRMLDKNPETRIGV 400
Cdd:cd14066   186 VVLLELLTGKPAVDENRENASRKDLVEWV-----ESKGKEELEDILDKRLVDDDGVEEEE 240
STKc_GAK cd14036
Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs ...
196-403 2.43e-16

Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GAK, also called auxilin-2, contains an N-terminal kinase domain that phosphorylates the mu subunits of adaptor protein (AP) 1 and AP2. In addition, it contains an auxilin-1-like domain structure consisting of PTEN-like, clathrin-binding, and J domains. Like auxilin-1, GAK facilitates Hsc70-mediated dissociation of clathrin from clathrin-coated vesicles. GAK is expressed ubiquitously and is enriched in the Golgi, unlike auxilin-1 which is nerve-specific. GAK also plays regulatory roles outside of clathrin-mediated membrane traffic including the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses through interaction with the interleukin 12 receptor. It also interacts with the androgen receptor, acting as a transcriptional coactivator, and its expression is significantly increased with the progression of prostate cancer. The GAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270938 [Multi-domain]  Cd Length: 282  Bit Score: 79.48  E-value: 2.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 196 VYQEIAILKKLD-HVNVVKLIEVLDDPAEDNL-----YLVFDLLRKGPVME----VPCDKPFPEEQARLYLRDIILGLEY 265
Cdd:cd14036    44 IIQEINFMKKLSgHPNIVQFCSAASIGKEESDqgqaeYLLLTELCKGQLVDfvkkVEAPGPFSPDTVLKIFYQTCRAVQH 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQK--IVHRDIKPSNLLLGDDGHVKIADFGvSNQFEGNDAQLSSTAG-------------TPAFMAPEAISDSGQSFS 330
Cdd:cd14036   124 MHKQSppIIHRDLKIENLLIGNQGQIKLCDFG-SATTEAHYPDYSWSAQkrslvedeitrntTPMYRTPEMIDLYSNYPI 202
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 331 GKALDVWATGVTLYCFVYGKCPFIDDYILtlhrKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd14036   203 GEKQDIWALGCILYLLCFRKHPFEDGAKL----RIINAKYTIPPNDTQYTVFHDLIRSTLKVNPEERLSITEI 271
STKc_TLK2 cd14041
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2; STKs catalyze the ...
198-412 2.49e-16

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270943 [Multi-domain]  Cd Length: 309  Bit Score: 79.72  E-value: 2.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPAeDNLYLVFDLLRKGPV-MEVPCDKPFPEEQARLYLRDIILGLEYLHCQK--IVHR 274
Cdd:cd14041    59 REYRIHKELDHPRIVKLYDYFSLDT-DSFCTVLEYCEGNDLdFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKppIIHY 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDD---GHVKIADFGVSNQFEGND------AQLSST-AGTPAFMAPE--AISDSGQSFSGKaLDVWATGVT 342
Cdd:cd14041   138 DLKPGNILLVNGtacGEIKITDFGLSKIMDDDSynsvdgMELTSQgAGTYWYLPPEcfVVGKEPPKISNK-VDVWSVGVI 216
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 343 LYCFVYGKCPFIDDY----ILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKH 412
Cdd:cd14041   217 FYQCLYGRKPFGHNQsqqdILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPH 290
PK_GC cd13992
Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows ...
188-404 2.72e-16

Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270894 [Multi-domain]  Cd Length: 268  Bit Score: 78.97  E-value: 2.72e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 188 KQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEVPCDKPFP-EEQARL-YLRDIILGLEY 265
Cdd:cd13992    35 FSRTEKRTILQELNQLKELVHDNLNKFIGICINP--PNIAVVTEYCTRGSLQDVLLNREIKmDWMFKSsFIKDIVKGMNY 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKI-VHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPA---FMAPEAISDSGQSFSG-KALDVWATG 340
Cdd:cd13992   113 LHSSSIgYHGRLKSSNCLVDSRWVVKLTDFGLRNLLEEQTNHQLDEDAQHKkllWTAPELLRGSLLEVRGtQKGDVYSFA 192
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 341 VTLYCFVYGKCPFIDDYILTLHRK-IKNEAVVFPEEP-----EVSEDLKDLILRMLDKNPETRIGVSDIK 404
Cdd:cd13992   193 IILYEILFRSDPFALEREVAIVEKvISGGNKPFRPELavlldEFPPRLVLLVKQCWAENPEKRPSFKQIK 262
STKc_TAO1 cd06635
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze ...
133-415 2.86e-16

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO1 is sometimes referred to as prostate-derived sterile 20-like kinase 2 (PSK2). TAO1 activates the p38 MAPK through direct interaction with and activation of MEK3. TAO1 is highly expressed in the brain and may play a role in neuronal apoptosis. TAO1 interacts with the checkpoint proteins BubR1 and Mad2, and plays an important role in regulating mitotic progression, which is required for both chromosome congression and checkpoint-induced anaphase delay. TAO1 may play a role in protecting genomic stability. TAO proteins possess MAPK kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270805 [Multi-domain]  Cd Length: 317  Bit Score: 79.71  E-value: 2.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 133 EIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfpRRPPPRGSQATQggpakqllPLERVYQEIAILKKLDHVNVV 212
Cdd:cd06635    32 EIGHGSFGAVYFARDVRTSEVVAI---------------KKMSYSGKQSNE--------KWQDIIKEVKFLQRIKHPNSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 213 KLIEVLDDPAEDNLYLVFDLLRKGPVMEVPcDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIA 292
Cdd:cd06635    89 EYKGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEIEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLA 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 293 DFGVSNQFegndAQLSSTAGTPAFMAPEAI--SDSGQsFSGKaLDVWATGVTLYCFVYGKCPFID-DYILTLHRKIKNEA 369
Cdd:cd06635   168 DFGSASIA----SPANSFVGTPYWMAPEVIlaMDEGQ-YDGK-VDVWSLGITCIELAERKPPLFNmNAMSALYHIAQNES 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1384865967 370 VVFpEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKHGEE 415
Cdd:cd06635   242 PTL-QSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHMFVLRERPE 286
STKc_PCTAIRE3 cd07871
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer ...
198-353 3.26e-16

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-3 shows a restricted pattern of expression and is present in brain, kidney, and intestine. It is elevated in Alzheimer's disease (AD) and has been shown to associate with paired helical filaments (PHFs) and stimulate Tau phosphorylation. As AD progresses, phosphorylated Tau aggregates and forms PHFs, which leads to the formation of neurofibrillary tangles. In human glioma cells, PCTAIRE-3 induces cell cycle arrest and cell death. PCTAIRE-3 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270853 [Multi-domain]  Cd Length: 288  Bit Score: 78.90  E-value: 3.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVP-CDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd07871    52 REVSLLKNLKHANIVTLHDIIH--TERCLTLVFEYLDSDLKQYLDnCGNLMSMHNVKIFMFQLLRGLSYCHKRKILHRDL 129
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPF 353
Cdd:cd07871   130 KPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL--LGSTEYSTPIDMWGVGCILYEMATGRPMF 204
PTKc_Jak1_rpt2 cd05079
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the ...
173-403 3.62e-16

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, including those that use the shared receptor subunits common gamma chain (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) and gp130 (IL-6, IL-11, oncostatin M, G-CSF, and IFNs, among others). The many varied interactions of Jak1 and its ubiquitous expression suggest many biological roles. Jak1 is important in neurological development, as well as in lymphoid development and function. It also plays a role in the pathophysiology of cardiac hypertrophy and heart failure. A mutation in the ATP-binding site of Jak1 was identified in a human uterine leiomyosarcoma cell line, resulting in defective cytokine induction and antigen presentation, thus allowing the tumor to evade the immune system. Jak1 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Jak1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173644 [Multi-domain]  Cd Length: 284  Bit Score: 78.82  E-value: 3.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 173 RPPPRGSQATQGGPAKQLLPLER------VYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVpcdkp 246
Cdd:cd05079    24 RYDPEGDNTGEQVAVKSLKPESGgnhiadLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEY----- 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 247 FPEEQARLYLR-------DIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDA--QLSSTAGTPAF- 316
Cdd:cd05079    99 LPRNKNKINLKqqlkyavQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEyyTVKDDLDSPVFw 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 317 MAPEAISdsgQSFSGKALDVWATGVTLY---CFVYGKCPFIDDYI---------LTLHRKIK--NEAVVFPEEPEVSEDL 382
Cdd:cd05079   179 YAPECLI---QSKFYIASDVWSFGVTLYellTYCDSESSPMTLFLkmigpthgqMTVTRLVRvlEEGKRLPRPPNCPEEV 255
                         250       260
                  ....*....|....*....|.
gi 1384865967 383 KDLILRMLDKNPETRIGVSDI 403
Cdd:cd05079   256 YQLMRKCWEFQPSKRTTFQNL 276
STKc_TLK1 cd14040
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the ...
198-412 4.65e-16

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A splice variant of TLK1, called TLK1B, is expressed in the presence of double strand breaks (DSBs). It lacks the N-terminal part of TLK1, but is expected to phosphorylate the same substrates. TLK1/1B interacts with Rad9, which is critical in DNA damage-activated checkpoint response, and plays a role in the repair of linearized DNA with incompatible ends. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. The TLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270942 [Multi-domain]  Cd Length: 299  Bit Score: 78.95  E-value: 4.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPAeDNLYLVFDLLRKGPV-MEVPCDKPFPEEQARLYLRDIILGLEYLHCQK--IVHR 274
Cdd:cd14040    59 REYRIHKELDHPRIVKLYDYFSLDT-DTFCTVLEYCEGNDLdFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKppIIHY 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDD---GHVKIADFGVSNQFEGNDAQL------SSTAGTPAFMAPE--AISDSGQSFSGKaLDVWATGVTL 343
Cdd:cd14040   138 DLKPGNILLVDGtacGEIKITDFGLSKIMDDDSYGVdgmdltSQGAGTYWYLPPEcfVVGKEPPKISNK-VDVWSVGVIF 216
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 344 YCFVYGKCPFIDDY----ILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWVTKH 412
Cdd:cd14040   217 FQCLYGRKPFGHNQsqqdILQENTILKATEVQFPVKPVVSNEAKAFIRRCLAYRKEDRFDVHQLASDPYLLPH 289
STKc_LIMK1 cd14221
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the ...
198-358 4.98e-16

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK1 activation is induced by bone morphogenic protein, vascular endothelial growth factor, and thrombin. It plays roles in microtubule disassembly and cell cycle progression, and is critical in the regulation of neurite outgrowth. LIMK1 knockout mice show abnormalities in dendritic spine morphology and synaptic function. LIMK1 is one of the genes deleted in patients with Williams Syndrome, which is characterized by distinct craniofacial features, cardiovascular problems, as well as behavioral and neurological abnormalities. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271123 [Multi-domain]  Cd Length: 267  Bit Score: 78.07  E-value: 4.98e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd14221    39 KEVKVMRCLEHPNVLKFIGVL--YKDKRLNFITEYIKGGTLRGIikSMDSHYPWSQRVSFAKDIASGMAYLHSMNIIHRD 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLLGDDGHVKIADFGVS-------NQFEGNDAQLS-------STAGTPAFMAPEAIsdSGQSFSGKaLDVWATGV 341
Cdd:cd14221   117 LNSHNCLVRENKSVVVADFGLArlmvdekTQPEGLRSLKKpdrkkryTVVGNPYWMAPEMI--NGRSYDEK-VDVFSFGI 193
                         170
                  ....*....|....*..
gi 1384865967 342 TLyCFVYGKCPFIDDYI 358
Cdd:cd14221   194 VL-CEIIGRVNADPDYL 209
PTKc_Fes_like cd05041
Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; ...
198-353 5.44e-16

Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; Fes subfamily; catalytic (c) domain. Fes subfamily members include Fes (or Fps), Fer, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes subfamily proteins are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated tyr kinase activity. Fes and Fer kinases play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Fes and Fer show redundancy in their biological functions.


Pssm-ID: 270637 [Multi-domain]  Cd Length: 251  Bit Score: 77.48  E-value: 5.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVpcdkpFPEEQARLYLR-------DIILGLEYLHCQK 270
Cdd:cd05041    42 QEARILKQYDHPNIVKLIGVCVQ--KQPIMIVMELVPGGSLLTF-----LRKKGARLTVKqllqmclDAAAGMEYLESKN 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG-TP-AFMAPEAIsDSGQSFSgkALDVWATGVTLY-CFV 347
Cdd:cd05041   115 CIHRDLAARNCLVGENNVLKISDFGMSREEEDGEYTVSDGLKqIPiKWTAPEAL-NYGRYTS--ESDVWSFGILLWeIFS 191

                  ....*.
gi 1384865967 348 YGKCPF 353
Cdd:cd05041   192 LGATPY 197
STKc_CDK6 cd07862
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs ...
127-340 6.71e-16

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK6 is regulated by D-type cyclins and INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein, implicating it to function in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the cytoplasm. It is also present in the ruffling edge of spreading fibroblasts and may play a role in cell spreading. It binds to the p21 inhibitor without any effect on its own activity and it is overexpressed in squamous cell carcinomas and neuroblastomas. CDK6 has also been shown to inhibit cell differentiation in many cell types. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270846 [Multi-domain]  Cd Length: 290  Bit Score: 78.15  E-value: 6.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYN-ESEDRHYAMKVLSKkkllkqygfprrppprgsQATQGGpakqlLPLERVyQEIAILKK 205
Cdd:cd07862     2 QYECVAEIGEGAYGKVFKARDlKNGGRFVALKRVRV------------------QTGEEG-----MPLSTI-REVAVLRH 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 L---DHVNVVKLIEVLD---DPAEDNLYLVFDLLRKG--PVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIK 277
Cdd:cd07862    58 LetfEHPNVVRLFDVCTvsrTDRETKLTLVFEHVDQDltTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLK 137
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 278 PSNLLLGDDGHVKIADFGVSNQFEGNDAqLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATG 340
Cdd:cd07862   138 PQNILVTSSGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVLL---QSSYATPVDLWSVG 196
STKc_obscurin_rpt2 cd14110
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
128-409 7.93e-16

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271012 [Multi-domain]  Cd Length: 257  Bit Score: 77.27  E-value: 7.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 128 YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVlskkkllkqygFPRRPPPRGSqatqggpakqllplerVYQEIAILKKLD 207
Cdd:cd14110     5 YAFQTEINRGRFSVVRQCEEKRSGQMLAAKI-----------IPYKPEDKQL----------------VLREYQVLRRLS 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDPAedNLYLVFDLLrKGPVMeVPC---DKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG 284
Cdd:cd14110    58 HPRIAQLHSAYLSPR--HLVLIEELC-SGPEL-LYNlaeRNSYSEAEVTDYLWQILSAVDYLHSRRILHLDLRSENMIIT 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 285 DDGHVKIADFGVSNQFEGNDAQLSSTAGTPAF-MAPEAISDSGqsfSGKALDVWATGVTLYCFVYGKCPFIDDYILTLHR 363
Cdd:cd14110   134 EKNLLKIVDLGNAQPFNQGKVLMTDKKGDYVEtMAPELLEGQG---AGPQTDIWAIGVTAFIMLSADYPVSSDLNWERDR 210
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1384865967 364 KIKNEAVVFPE-EPEVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14110   211 NIRKGKVQLSRcYAGLSGGAVNFLKSTLCAKPWGRPTASECLQNPWL 257
STKc_JNK1 cd07875
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the ...
125-409 8.06e-16

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK1 is expressed in every cell and tissue type. It specifically binds with JAMP (JNK1-associated membrane protein), which regulates the duration of JNK1 activity in response to stimuli. Specific JNK1 substrates include Itch and SG10, which are implicated in Th2 responses and airway inflammation, and microtubule dynamics and axodendritic length, respectively. Mice deficient in JNK1 are protected against arthritis, obesity, type 2 diabetes, cardiac cell death, and non-alcoholic liver disease, suggesting that JNK1 may play roles in the pathogenesis of these diseases. Initially, it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143380 [Multi-domain]  Cd Length: 364  Bit Score: 78.93  E-value: 8.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSkkkllkqygfprRPPPRGSQAtqggpakqllplERVYQEIAILK 204
Cdd:cd07875    23 LKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLS------------RPFQNQTHA------------KRAYRELVLMK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDDPAE----DNLYLVFDLLRKG--PVMEVPCDkpfpEEQARLYLRDIILGLEYLHCQKIVHRDIKP 278
Cdd:cd07875    79 CVNHKNIIGLLNVFTPQKSleefQDVYIVMELMDANlcQVIQMELD----HERMSYLLYQMLCGIKHLHSAGIIHRDLKP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 279 SNLLLGDDGHVKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTLYCFVYGK-------- 350
Cdd:cd07875   155 SNIVVKSDCTLKILDFGLA-RTAGTSFMMTPYVVTRYYRAPEVILGMGYK---ENVDIWSVGCIMGEMIKGGvlfpgtdh 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 351 --------------CP-FIDDYILTLHRKIKNEA-------------VVFPEEPE----VSEDLKDLILRMLDKNPETRI 398
Cdd:cd07875   231 idqwnkvieqlgtpCPeFMKKLQPTVRTYVENRPkyagysfeklfpdVLFPADSEhnklKASQARDLLSKMLVIDASKRI 310
                         330
                  ....*....|.
gi 1384865967 399 GVSDIKLHPWV 409
Cdd:cd07875   311 SVDEALQHPYI 321
STKc_TAO2 cd06634
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze ...
194-397 8.46e-16

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human TAO2 is also known as prostate-derived Ste20-like kinase (PSK) and was identified in a screen for overexpressed RNAs in prostate cancer. TAO2 possesses mitogen-activated protein kinase (MAPK) kinase kinase activity and activates both p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating their respective MAP/ERK kinases, MEK3/MEK6 and MKK4/MKK7. It contains a long C-terminal extension with autoinhibitory segments, and is activated by the release of this inhibition and the phosphorylation of its activation loop serine. TAO2 functions as a regulator of actin cytoskeletal and microtubule organization. In addition, it regulates the transforming growth factor-activated kinase 1 (TAK1), which is a MAPKKK that plays an essential role in the signaling pathways of tumor necrosis factor, interleukin 1, and Toll-like receptor. The TAO2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270804 [Multi-domain]  Cd Length: 308  Bit Score: 78.14  E-value: 8.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPcDKPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:cd06634    60 QDIIKEVKFLQKLRHPNTIEYRGCYLREHTAWLVMEYCLGSASDLLEVH-KKPLQEVEIAAITHGALQGLAYLHSHNMIH 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLGDDGHVKIADFGVSNQFegndAQLSSTAGTPAFMAPEAI--SDSGQsFSGKaLDVWATGVTLYCFVYGKC 351
Cdd:cd06634   139 RDVKAGNILLTEPGLVKLGDFGSASIM----APANSFVGTPYWMAPEVIlaMDEGQ-YDGK-VDVWSLGITCIELAERKP 212
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1384865967 352 PFID-DYILTLHRKIKNEAVVFpEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd06634   213 PLFNmNAMSALYHIAQNESPAL-QSGHWSEYFRNFVDSCLQKIPQDR 258
STKc_LIMK cd14154
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer ...
198-358 1.10e-15

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. Vertebrate have two members, LIMK1 and LIMK2. The LIMK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271056 [Multi-domain]  Cd Length: 272  Bit Score: 77.16  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEVPCDK--PFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd14154    39 KEVKVMRSLDHPNVLKFIGVL--YKDKKLNLITEYIPGGTLKDVLKDMarPLPWAQRVRFAKDIASGMAYLHSMNIIHRD 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLS--------------------STAGTPAFMAPEAIsdSGQSFSGKaLD 335
Cdd:cd14154   117 LNSHNCLVREDKTVVVADFGLARLIVEERLPSGnmspsetlrhlkspdrkkryTVVGNPYWMAPEML--NGRSYDEK-VD 193
                         170       180
                  ....*....|....*....|...
gi 1384865967 336 VWATGVTLyCFVYGKCPFIDDYI 358
Cdd:cd14154   194 IFSFGIVL-CEIIGRVEADPDYL 215
STKc_LIMK2 cd14222
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the ...
199-350 1.33e-15

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK2 activation is induced by transforming growth factor-beta l (TGFb-l) and shares the same subcellular location as the cofilin family member twinfilin, which may be its biological substrate. LIMK2 plays a role in spermatogenesis, and may contribute to tumor progression and metastasis formation in some cancer cells. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271124 [Multi-domain]  Cd Length: 272  Bit Score: 76.91  E-value: 1.33e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPAEDNLYLVF-------DLLRKgpvmevpcDKPFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd14222    40 EVKVMRSLDHPNVLKFIGVLYKDKRLNLLTEFieggtlkDFLRA--------DDPFPWQQKVSFAKGIASGMAYLHSMSI 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGVS-------------------NQFEGNDAQLSST-AGTPAFMAPEAIsdSGQSFSG 331
Cdd:cd14222   112 IHRDLNSHNCLIKLDKTVVVADFGLSrliveekkkpppdkpttkkRTLRKNDRKKRYTvVGNPYWMAPEML--NGKSYDE 189
                         170
                  ....*....|....*....
gi 1384865967 332 KaLDVWATGVTLyCFVYGK 350
Cdd:cd14222   190 K-VDIFSFGIVL-CEIIGQ 206
PTKc_Jak3_rpt2 cd05081
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the ...
183-348 1.52e-15

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak3 is expressed only in hematopoietic cells. It binds the shared receptor subunit common gamma chain and thus, is essential in the signaling of cytokines that use it such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is important in lymphoid development and myeloid cell differentiation. Inactivating mutations in Jak3 have been reported in humans with severe combined immunodeficiency (SCID). Jak3 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270665 [Multi-domain]  Cd Length: 283  Bit Score: 76.86  E-value: 1.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 183 QGGPAKQLLPLERvyqEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVpcdkpFPEEQARL-------Y 255
Cdd:cd05081    42 QHSGPDQQRDFQR---EIQILKALHSDFIVKYRGVSYGPGRRSLRLVMEYLPSGCLRDF-----LQRHRARLdasrlllY 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 256 LRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF-EGNDAQLSSTAG-TPAF-MAPEAISDSGQSfsgK 332
Cdd:cd05081   114 SSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLpLDKDYYVVREPGqSPIFwYAPESLSDNIFS---R 190
                         170
                  ....*....|....*..
gi 1384865967 333 ALDVWATGVTLY-CFVY 348
Cdd:cd05081   191 QSDVWSFGVVLYeLFTY 207
STKc_PIM3 cd14102
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
178-409 1.57e-15

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3). PIM3 can inhibit apoptosis and promote cell survival and protein translation, therefore, it can enhance the proliferation of normal and cancer cells. Mice deficient with PIM3 show minimal effects, suggesting that PIM3 msy not be essential. Since its expression is enhanced in several cancers, it may make a good molecular target for cancer drugs. The PIM3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271004 [Multi-domain]  Cd Length: 253  Bit Score: 76.53  E-value: 1.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 178 GSQATQGGP-AKQLLPLERVYQ-----------EIAILKKLDHV--NVVKLIEVLDDPaeDNLYLVFDllRKGPVME--- 240
Cdd:cd14102    19 GSRIADGLPvAVKHVVKERVTEwgtlngvmvplEIVLLKKVGSGfrGVIKLLDWYERP--DGFLIVME--RPEPVKDlfd 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 241 -VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLG-DDGHVKIADFGVSNQFEgnDAQLSSTAGTPAFMA 318
Cdd:cd14102    95 fITEKGALDEDTARGFFRQVLEAVRHCYSCGVVHRDIKDENLLVDlRTGELKLIDFGSGALLK--DTVYTDFDGTRVYSP 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 319 PEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDyiltlhRKIKNEAVVFpeEPEVSEDLKDLILRMLDKNPETRI 398
Cdd:cd14102   173 PEWI--RYHRYHGRSATVWSLGVLLYDMVCGDIPFEQD------EEILRGRLYF--RRRVSPECQQLIKWCLSLRPSDRP 242
                         250
                  ....*....|.
gi 1384865967 399 GVSDIKLHPWV 409
Cdd:cd14102   243 TLEQIFDHPWM 253
STKc_PCTAIRE2 cd07872
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer ...
198-353 3.00e-15

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-2 is specifically expressed in neurons in the central nervous system, mainly in terminally differentiated neurons. It associates with Trap (Tudor repeat associator with PCTAIRE-2) and could play a role in regulating mitochondrial function in neurons. PCTAIRE-2 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143377 [Multi-domain]  Cd Length: 309  Bit Score: 76.57  E-value: 3.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVP-CDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd07872    53 REVSLLKDLKHANIVTLHDIVH--TDKSLTLVFEYLDKDLKQYMDdCGNIMSMHNVKIFLYQILRGLAYCHRRKVLHRDL 130
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGKCPF 353
Cdd:cd07872   131 KPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL--LGSSEYSTQIDMWGVGCIFFEMASGRPLF 205
PTKc_Tyro3 cd05074
Catalytic domain of the Protein Tyrosine Kinase, Tyro3; PTKs catalyze the transfer of the ...
123-404 3.02e-15

Catalytic domain of the Protein Tyrosine Kinase, Tyro3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyro3 (or Sky) is predominantly expressed in the central nervous system and the brain, and functions as a neurotrophic factor. It is also expressed in osteoclasts and has a role in bone resorption. Tyro3 is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Tyro3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270659 [Multi-domain]  Cd Length: 284  Bit Score: 76.11  E-value: 3.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 123 VQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYamkvlskkkllkqygfprrppprgsqatQGGPAKQLLP-------LER 195
Cdd:cd05074     6 IQEQQFTLGRMLGKGEFGSVREAQLKSEDGSF----------------------------QKVAVKMLKAdifsssdIEE 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 196 VYQEIAILKKLDHVNVVKLIEV-LDDPAEDNL---YLVFDLLRKGPV-----MEVPCDKPF--PEEQARLYLRDIILGLE 264
Cdd:cd05074    58 FLREAACMKEFDHPNVIKLIGVsLRSRAKGRLpipMVILPFMKHGDLhtfllMSRIGEEPFtlPLQTLVRFMIDIASGME 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 265 YLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ-FEGNDAQLSSTAGTPA-FMAPEAISDSGQSFSGkalDVWATGVT 342
Cdd:cd05074   138 YLSSKNFIHRDLAARNCMLNENMTVCVADFGLSKKiYSGDYYRQGCASKLPVkWLALESLADNVYTTHS---DVWAFGVT 214
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 343 LYCFV-YGKCPF-------IDDYILTLHRkikneavvFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIK 404
Cdd:cd05074   215 MWEIMtRGQTPYagvenseIYNYLIKGNR--------LKQPPDCLEDVYELMCQCWSPEPKCRPSFQHLR 276
PTKc_Jak2_rpt2 cd14205
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the ...
183-348 4.45e-15

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak2 is widely expressed in many tissues and is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis. Jak2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271107 [Multi-domain]  Cd Length: 284  Bit Score: 75.44  E-value: 4.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 183 QGGPAKQLLPLERvyqEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDII 260
Cdd:cd14205    42 QHSTEEHLRDFER---EIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYlqKHKERIDHIKLLQYTSQIC 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 261 LGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDA--QLSSTAGTPAF-MAPEAISDSGQSFsgkALDVW 337
Cdd:cd14205   119 KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEyyKVKEPGESPIFwYAPESLTESKFSV---ASDVW 195
                         170
                  ....*....|..
gi 1384865967 338 ATGVTLY-CFVY 348
Cdd:cd14205   196 SFGVVLYeLFTY 207
PTKc_Fes cd05084
Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the ...
188-353 5.31e-15

Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes (or Fps) is a cytoplasmic (or nonreceptor) PTK containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated PTK activity. Fes kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells. It plays important roles in cell growth and differentiation, angiogenesis, inflammation and immunity, and cytoskeletal regulation. A recent study implicates Fes kinase as a tumor suppressor in colorectal cancer. The Fes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270667 [Multi-domain]  Cd Length: 252  Bit Score: 74.97  E-value: 5.31e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 188 KQLLPLE---RVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVpcdkpFPEEQARLYLRDII---- 260
Cdd:cd05084    30 RETLPPDlkaKFLQEARILKQYSHPNIVRLIGVCTQ--KQPIYIVMELVQGGDFLTF-----LRTEGPRLKVKELIrmve 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 261 ---LGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEgnDAQLSSTAGTP----AFMAPEAIsDSGQsFSGKA 333
Cdd:cd05084   103 naaAGMEYLESKHCIHRDLAARNCLVTEKNVLKISDFGMSREEE--DGVYAATGGMKqipvKWTAPEAL-NYGR-YSSES 178
                         170       180
                  ....*....|....*....|.
gi 1384865967 334 lDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05084   179 -DVWSFGILLWeTFSLGAVPY 198
PTKc_Lyn cd05072
Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the ...
191-397 5.83e-15

Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lyn subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270657 [Multi-domain]  Cd Length: 272  Bit Score: 75.08  E-value: 5.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 191 LPLERVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMevpcDKPFPEEQARLYLRDII-------LGL 263
Cdd:cd05072    44 MSVQAFLEEANLMKTLQHDKLVRLYAVVTK--EEPIYIITEYMAKGSLL----DFLKSDEGGKVLLPKLIdfsaqiaEGM 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 264 EYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAISDSgqSFSGKAlDVWATGVT 342
Cdd:cd05072   118 AYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPiKWTAPEAINFG--SFTIKS-DVWSFGIL 194
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 343 LYCFV-YGKCPFI----DDYILTLHRKIKneavvFPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd05072   195 LYEIVtYGKIPYPgmsnSDVMSALQRGYR-----MPRMENCPDELYDIMKTCWKEKAEER 249
STKc_LRRK cd14000
Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the ...
198-397 6.85e-15

Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. Vertebrates contain two members, LRRK1 and LRRK2, which show complementary expression in the brain. Mutations in LRRK2 are linked to both familial and sporadic forms of Parkinson's disease. The normal roles of LRRKs are not clearly defined. They may be involved in mitogen-activated protein kinase (MAPK) pathways, protein translation control, programmed cell death pathways, and cytoskeletal dynamics. The LRRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270902 [Multi-domain]  Cd Length: 275  Bit Score: 74.96  E-value: 6.85e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPaednLYLVFDLLRKGPVMEVPCDKPF------PEEQARLYLRdIILGLEYLHCQKI 271
Cdd:cd14000    59 QELTVLSHLHHPSIVYLLGIGIHP----LMLVLELAPLGSLDHLLQQDSRsfaslgRTLQQRIALQ-VADGLRYLHSAMI 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLL-----GDDGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCF 346
Cdd:cd14000   134 IYRDLKSHNVLVwtlypNSAIIIKIADYGISRQCCRMGAK--GSEGTPGFRAPEIA--RGNVIYNEKVDVFSFGMLLYEI 209
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 347 VYGKCPFIDdyiltlHRKIKNE---------AVVFPEEPEVSEdLKDLILRMLDKNPETR 397
Cdd:cd14000   210 LSGGAPMVG------HLKFPNEfdihgglrpPLKQYECAPWPE-VEVLMKKCWKENPQQR 262
PLN00009 PLN00009
cyclin-dependent kinase A; Provisional
125-401 8.32e-15

cyclin-dependent kinase A; Provisional


Pssm-ID: 177649 [Multi-domain]  Cd Length: 294  Bit Score: 74.85  E-value: 8.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 125 LNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLlplervyQEIAILK 204
Cdd:PLN00009    1 MDQYEKVEKIGEGTYGVVYKARDRVTNETIALKKI-----------------RLEQEDEGVPSTAI-------REISLLK 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQ--ARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:PLN00009   57 EMQHGNIVRLQDVVH--SEKRLYLVFEYLDLDLKKHMDSSPDFAKNPrlIKTYLYQILRGIAYCHSHRVLHRDLKPQNLL 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 283 LG-DDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGvtlycfvygkCPFIDdyiltl 361
Cdd:PLN00009  135 IDrRTNALKLADFGLARAFGIPVRTFTHEVVTLWYRAPEIL--LGSRHYSTPVDIWSVG----------CIFAE------ 196
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1384865967 362 hrkIKNEAVVFPEEPEVSEDLKdlILRMLDK-NPETRIGVS 401
Cdd:PLN00009  197 ---MVNQKPLFPGDSEIDELFK--IFRILGTpNEETWPGVT 232
STKc_PFTAIRE2 cd07870
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer ...
198-408 8.86e-15

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-2 is also referred to as ALS2CR7 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 7). It may be associated with amyotrophic lateral sclerosis 2 (ALS2), an autosomal recessive form of juvenile ALS. The function of PFTAIRE-2 is not yet known. It shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270852 [Multi-domain]  Cd Length: 286  Bit Score: 74.61  E-value: 8.86e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLR--------KGPVMEVPCDkpfpeeqARLYLRDIILGLEYLHCQ 269
Cdd:cd07870    47 REASLLKGLKHANIVLLHDIIH--TKETLTFVFEYMHtdlaqymiQHPGGLHPYN-------VRLFMFQLLRGLAYIHGQ 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 270 KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYG 349
Cdd:cd07870   118 HILHRDLKPQNLLISYLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDVL--LGATDYSSALDIWGAGCIFIEMLQG 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 350 KCPF--IDDYILTLHR--------------------KIKNEAVVFPEEPEVSE---------DLKDLILRMLDKNPETRI 398
Cdd:cd07870   196 QPAFpgVSDVFEQLEKiwtvlgvptedtwpgvsklpNYKPEWFLPCKPQQLRVvwkrlsrppKAEDLASQMLMMFPKDRI 275
                         250
                  ....*....|
gi 1384865967 399 GVSDIKLHPW 408
Cdd:cd07870   276 SAQDALLHPY 285
STKc_CDK5 cd07839
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs ...
127-340 9.70e-15

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK5 is unusual in that it is regulated by non-cyclin proteins, p35 and p39. It is highly expressed in the nervous system and is critical in normal neural development and function. It plays a role in neuronal migration and differentiation, and is also important in synaptic plasticity and learning. CDK5 also participates in protecting against cell death and promoting angiogenesis. Impaired CDK5 activity is implicated in Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease and acute neuronal injury. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143344 [Multi-domain]  Cd Length: 284  Bit Score: 74.39  E-value: 9.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLlplervyQEIAILKKL 206
Cdd:cd07839     1 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRV-----------------RLDDDDEGVPSSAL-------REICLLKEL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDdpAEDNLYLVFDL----LRKgpvMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLL 282
Cdd:cd07839    57 KHKNIVRLYDVLH--SDKKLTLVFEYcdqdLKK---YFDSCNGDIDPEIVKSFMFQLLKGLAFCHSHNVLHRDLKPQNLL 131
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 283 LGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATG 340
Cdd:cd07839   132 INKNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL--FGAKLYSTSIDMWSAG 187
PTKc_FGFR cd05053
Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs ...
199-353 1.13e-14

Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The FGFR subfamily consists of FGFR1, FGFR2, FGFR3, FGFR4, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, and to heparin/heparan sulfate (HS) results in the formation of a ternary complex, which leads to receptor dimerization and activation, and intracellular signaling. There are at least 23 FGFs and four types of FGFRs. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. FGF/FGFR signaling is important in the regulation of embryonic development, homeostasis, and regenerative processes. Depending on the cell type and stage, FGFR signaling produces diverse cellular responses including proliferation, growth arrest, differentiation, and apoptosis. Aberrant signaling leads to many human diseases such as skeletal, olfactory, and metabolic disorders, as well as cancer. The FGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 270646 [Multi-domain]  Cd Length: 294  Bit Score: 74.38  E-value: 1.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKL-DHVNVVKLIEVLDDpaEDNLYLVFDLLRKG-----------PVMEVPCDKPFPEEQaRLYLRDII------ 260
Cdd:cd05053    66 EMEMMKMIgKHKNIINLLGACTQ--DGPLYVVVEYASKGnlreflrarrpPGEEASPDDPRVPEE-QLTQKDLVsfayqv 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 261 -LGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG-TPA-FMAPEAISD---SGQSfsgkal 334
Cdd:cd05053   143 aRGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYRKTTNGrLPVkWMAPEALFDrvyTHQS------ 216
                         170       180
                  ....*....|....*....|
gi 1384865967 335 DVWATGVTLY-CFVYGKCPF 353
Cdd:cd05053   217 DVWSFGVLLWeIFTLGGSPY 236
STKc_MLTK cd14060
Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated ...
188-353 1.30e-14

Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLTK, also called zipper sterile-alpha-motif kinase (ZAK), contains a catalytic kinase domain and a leucine zipper. There are two alternatively-spliced variants, MLTK-alpha and MLTK-beta. MLTK-alpha contains a sterile-alpha-motif (SAM) at the C-terminus. MLTK regulates the c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38 MAPK, and NF-kB pathways. ZAK is the MAP3K involved in the signaling cascade that leads to the ribotoxic stress response initiated by cellular damage due to Shiga toxins and ricin. It may also play a role in cell transformation and cancer development. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals.The MLTK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270962 [Multi-domain]  Cd Length: 242  Bit Score: 73.45  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 188 KQLLPLERvyqEIAILKKLDHVNVVKLIEVLDDPAedNLYLVFDLLRKGPVMEVPCDKPFPE---EQARLYLRDIILGLE 264
Cdd:cd14060    24 KKLLKIEK---EAEILSVLSHRNIIQFYGAILEAP--NYGIVTEYASYGSLFDYLNSNESEEmdmDQIMTWATDIAKGMH 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 265 YLHCQ---KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFegNDAQLSSTAGTPAFMAPEAIsdsgQSF-SGKALDVWATG 340
Cdd:cd14060    99 YLHMEapvKVIHRDLKSRNVVIAADGVLKICDFGASRFH--SHTTHMSLVGTFPWMAPEVI----QSLpVSETCDTYSYG 172
                         170
                  ....*....|...
gi 1384865967 341 VTLYCFVYGKCPF 353
Cdd:cd14060   173 VVLWEMLTREVPF 185
PKc_TNNI3K cd14064
Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; ...
198-353 1.48e-14

Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TNNI3K, also called cardiac ankyrin repeat kinase (CARK), is a cardiac-specific troponin I-interacting kinase that promotes cardiac myogenesis, improves cardiac performance, and protects the myocardium from ischemic injury. It contains N-terminal ankyrin repeats, a catalytic kinase domain, and a C-terminal serine-rich domain. TNNI3K exerts a disease-accelerating effect on cardiac dysfunction and reduced survival in mouse models of cardiomyopathy. The TNNI3K subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270966 [Multi-domain]  Cd Length: 254  Bit Score: 73.33  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLI-EVLDDPAEdnLYLVFDLLRKGPVMEV-PCDKPFPEEQARLYLR-DIILGLEYLH--CQKIV 272
Cdd:cd14064    40 REVSILCRLNHPCVIQFVgACLDDPSQ--FAIVTQYVSGGSLFSLlHEQKRVIDLQSKLIIAvDVAKGMEYLHnlTQPII 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSNQFEG-NDAQLSSTAGTPAFMAPEAISDSGQsFSGKAlDVWATGVTLYCFVYGKC 351
Cdd:cd14064   118 HRDLNSHNILLYEDGHAVVADFGESRFLQSlDEDNMTKQPGNLRWMAPEVFTQCTR-YSIKA-DVFSYALCLWELLTGEI 195

                  ..
gi 1384865967 352 PF 353
Cdd:cd14064   196 PF 197
PTKc_Trk cd05049
Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze ...
198-403 1.78e-14

Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Trk subfamily consists of TrkA, TrkB, TrkC, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, the nerve growth factor (NGF) family of neutrotrophins, leads to Trk receptor oligomerization and activation of the catalytic domain. Trk receptors are mainly expressed in the peripheral and central nervous systems. They play important roles in cell fate determination, neuronal survival and differentiation, as well as in the regulation of synaptic plasticity. Altered expression of Trk receptors is associated with many human diseases. The Trk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270643 [Multi-domain]  Cd Length: 280  Bit Score: 73.65  E-value: 1.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFD----------LLRKGP---VMEVPCDKPFPEEQARLY--LRDIILG 262
Cdd:cd05049    57 REAELLTNLQHENIVKFYGVCTE--GDPLLMVFEymehgdlnkfLRSHGPdaaFLASEDSAPGELTLSQLLhiAVQIASG 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGND-AQLSSTAGTPA-FMAPEAIsdSGQSFSGKAlDVWATG 340
Cdd:cd05049   135 MVYLASQHFVHRDLATRNCLVGTNLVVKIGDFGMSRDIYSTDyYRVGGHTMLPIrWMPPESI--LYRKFTTES-DVWSFG 211
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1384865967 341 VTLY-CFVYGKCPFIddyiltlhrKIKNEAVV-------FPEEPEVSED-LKDLILRMLDKNPETRIGVSDI 403
Cdd:cd05049   212 VVLWeIFTYGKQPWF---------QLSNTEVIecitqgrLLQRPRTCPSeVYAVMLGCWKREPQQRLNIKDI 274
PTZ00283 PTZ00283
serine/threonine protein kinase; Provisional
195-397 1.85e-14

serine/threonine protein kinase; Provisional


Pssm-ID: 240344 [Multi-domain]  Cd Length: 496  Bit Score: 75.68  E-value: 1.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 195 RVYQEIAILKKLDHVNVVKLIE--VLDDPA-EDN---LYLVFDL-----LRKGPVMEVPCDKPFPEEQARLYLRDIILGL 263
Cdd:PTZ00283   77 RAQAEVCCLLNCDFFSIVKCHEdfAKKDPRnPENvlmIALVLDYanagdLRQEIKSRAKTNRTFREHEAGLLFIQVLLAV 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 264 EYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG--NDAQLSSTAGTPAFMAPEAISDsgQSFSGKAlDVWATGV 341
Cdd:PTZ00283  157 HHVHSKHMIHRDIKSANILLCSNGLVKLGDFGFSKMYAAtvSDDVGRTFCGTPYYVAPEIWRR--KPYSKKA-DMFSLGV 233
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 342 TLYCFVYGKCPFIDDYIL-TLHRKIKNEAVVFPeePEVSEDLKDLILRMLDKNPETR 397
Cdd:PTZ00283  234 LLYELLTLKRPFDGENMEeVMHKTLAGRYDPLP--PSISPEMQEIVTALLSSDPKRR 288
PKc_LIMK_like cd14065
Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of ...
198-358 2.28e-14

Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. Members of this subfamily include LIMK, Testicular or testis-specific protein kinase (TESK), and similar proteins. LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270967 [Multi-domain]  Cd Length: 252  Bit Score: 72.91  E-value: 2.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEV--PCDKPFPEEQaRLYL-RDIILGLEYLHCQKIVHR 274
Cdd:cd14065    37 KEVKLMRRLSHPNILRFIGVC--VKDNKLNFITEYVNGGTLEELlkSMDEQLPWSQ-RVSLaKDIASGMAYLHSKNIIHR 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLL--GDDG-HVKIADFGVSNQF------EGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLyC 345
Cdd:cd14065   114 DLNSKNCLVreANRGrNAVVADFGLAREMpdektkKPDRKKRLTVVGSPYWMAPEML--RGESYDEKV-DVFSFGIVL-C 189
                         170
                  ....*....|...
gi 1384865967 346 FVYGKCPFIDDYI 358
Cdd:cd14065   190 EIIGRVPADPDYL 202
K-ycf53 COG5752
Signaling protein combining a Ser/Thr protein kinase domain and the GUN4/Ycf53 ...
223-342 2.55e-14

Signaling protein combining a Ser/Thr protein kinase domain and the GUN4/Ycf53 porphyrin-binding domain [Signal transduction mechanisms];


Pssm-ID: 444462 [Multi-domain]  Cd Length: 466  Bit Score: 75.04  E-value: 2.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 223 EDNLYLVFDLLrKGPVM--EVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGD-DGHVKIADFGVSNq 299
Cdd:COG5752   110 DQRLYLVQEFI-EGQTLaqELEKKGVFSESQIWQLLKDLLPVLQFIHSRNVIHRDIKPANIIRRRsDGKLVLIDFGVAK- 187
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 300 fegndaQLSSTA--------GTPAFMAPEAIsdSGQSFsgKALDVWATGVT 342
Cdd:COG5752   188 ------LLTITAllqtgtiiGTPEYMAPEQL--RGKVF--PASDLYSLGVT 228
STKc_CdkB_plant cd07837
Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; ...
126-408 2.58e-14

Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CdkB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270830 [Multi-domain]  Cd Length: 294  Bit Score: 73.33  E-value: 2.58e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprrpppRGSQATQGGPAKQLlplervyQEIAILKK 205
Cdd:cd07837     1 DAYEKLEKIGEGTYGKVYKARDKNTGKLVALKKT-----------------RLEMEEEGVPSTAL-------REVSLLQM 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVN-VVKLIEV--LDDPAEDNLYLVF-----------DLLRKGPvmevpcDKPFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd07837    57 LSQSIyIVRLLDVehVEENGKPLLYLVFeyldtdlkkfiDSYGRGP------HNPLPAKTIQSFMYQLCKGVAHCHSHGV 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDD-GHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYCFVYGK 350
Cdd:cd07837   131 MHRDLKPQNLLVDKQkGLLKIADLGLGRAFTIPIKSYTHEIVTLWYRAPEVL--LGSTHYSTPVDMWSVGCIFAEMSRKQ 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 351 CPFIDDYILTLHRKI------KNEAV-----------VFPE---------EPEVSEDLKDLILRMLDKNPETRIGVSDIK 404
Cdd:cd07837   209 PLFPGDSELQQLLHIfrllgtPNEEVwpgvsklrdwhEYPQwkpqdlsraVPDLEPEGVDLLTKMLAYDPAKRISAKAAL 288

                  ....
gi 1384865967 405 LHPW 408
Cdd:cd07837   289 QHPY 292
STKc_NIK cd13991
Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs ...
248-404 2.80e-14

Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIK, also called mitogen activated protein kinase kinase kinase 14 (MAP3K14), phosphorylates and activates Inhibitor of NF-KappaB Kinase (IKK) alpha, which is a regulator of NF-kB proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. NIK is essential in the IKKalpha-mediated non-canonical NF-kB signaling pathway, in which IKKalpha processes the IkB-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus where it regulates gene transcription. NIK also plays an important role in Toll-like receptor 7/9 signaling cascades. The NIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270893 [Multi-domain]  Cd Length: 268  Bit Score: 72.93  E-value: 2.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 248 PEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDG-HVKIADFGVSNQFEgnDAQLSSTA-------GTPAFMAP 319
Cdd:cd13991    96 PEDRALHYLGQALEGLEYLHSRKILHGDVKADNVLLSSDGsDAFLCDFGHAECLD--PDGLGKSLftgdyipGTETHMAP 173
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 320 EAIsdSGQSFSGKAlDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRM-LDKNPETRI 398
Cdd:cd13991   174 EVV--LGKPCDAKV-DVWSSCCMMLHMLNGCHPWTQYYSGPLCLKIANEPPPLREIPPSCAPLTAQAIQAgLRKEPVHRA 250

                  ....*.
gi 1384865967 399 GVSDIK 404
Cdd:cd13991   251 SAAELR 256
PTKc_Mer cd14204
Catalytic Domain of the Protein Tyrosine Kinase, Mer; PTKs catalyze the transfer of the ...
193-406 3.06e-14

Catalytic Domain of the Protein Tyrosine Kinase, Mer; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Mer (or Mertk) is named after its original reported expression pattern (monocytes, epithelial, and reproductive tissues). It is required for the ingestion of apoptotic cells by phagocytes such as macrophages, retinal pigment epithelial cells, and dendritic cells. Mer is also important in maintaining immune homeostasis. Mer is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Mer subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271106 [Multi-domain]  Cd Length: 284  Bit Score: 73.05  E-value: 3.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNL-----------------YLVFDLLRKGPVMevpcdkpFPEEQARLY 255
Cdd:cd14204    53 IEEFLSEAACMKDFNHPNVIRLLGVCLEVGSQRIpkpmvilpfmkygdlhsFLLRSRLGSGPQH-------VPLQTLLKF 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 256 LRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ-FEGNDAQLSSTAGTPA-FMAPEAISDsgQSFSGKA 333
Cdd:cd14204   126 MIDIALGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKiYSGDYYRQGRIAKMPVkWIAVESLAD--RVYTVKS 203
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 334 lDVWATGVTLY-CFVYGKCPF-------IDDYILTLHRkikneavvFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKL 405
Cdd:cd14204   204 -DVWAFGVTMWeIATRGMTPYpgvqnheIYDYLLHGHR--------LKQPEDCLDELYDIMYSCWRSDPTDRPTFTQLRE 274

                  .
gi 1384865967 406 H 406
Cdd:cd14204   275 N 275
STKc_PCTAIRE_like cd07844
Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
199-295 3.39e-14

Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-like proteins show unusual expression patterns with high levels in post-mitotic tissues, suggesting that they may be involved in regulating post-mitotic cellular events. They share sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The association of PCTAIRE-like proteins with cyclins has not been widely studied, although PFTAIRE-1 has been shown to function as a CDK which is regulated by cyclin D3 as well as the membrane-associated cyclin Y. The PCTAIRE-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270835 [Multi-domain]  Cd Length: 286  Bit Score: 72.80  E-value: 3.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRK--GPVMEvPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd07844    48 EASLLKDLKHANIVTLHDIIH--TKKTLTLVFEYLDTdlKQYMD-DCGGGLSMHNVRLFLFQLLRGLAYCHQRRVLHRDL 124
                          90
                  ....*....|....*....
gi 1384865967 277 KPSNLLLGDDGHVKIADFG 295
Cdd:cd07844   125 KPQNLLISERGELKLADFG 143
STKc_RIP4_like cd14025
Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar ...
198-405 4.50e-14

Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of RIP4, ankyrin (ANK) repeat and kinase domain containing 1 (ANKK1), and similar proteins, all of which harbor C-terminal ANK repeats. RIP4, also called Protein Kinase C-associated kinase (PKK), regulates keratinocyte differentiation and cutaneous inflammation. It activates NF-kappaB and is important in the survival of diffuse large B-cell lymphoma cells. The ANKK1 protein, also called PKK2, has not been studied extensively. The ANKK1 gene, located less than 10kb downstream of the D2 dopamine receptor (DRD2) locus, is altered in the Taq1 A1 polymorphism, which is related to a reduced DRD2 binding affinity and consequently, to mental disorders. The RIP4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270927 [Multi-domain]  Cd Length: 267  Bit Score: 72.14  E-value: 4.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPAEdnlyLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQK--IVHRD 275
Cdd:cd14025    44 EEAKKMEMAKFRHILPVYGICSEPVG----LVMEYMETGSLEKLLASEPLPWELRFRIIHETAVGMNFLHCMKppLLHLD 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLLGDDGHVKIADFGVSNQFEG-NDAQLSSTA--GTPAFMAPEAISDSGQSFsGKALDVWATGVTLYCFVYGKCP 352
Cdd:cd14025   120 LKPANILLDAHYHVKISDFGLAKWNGLsHSHDLSRDGlrGTIAYLPPERFKEKNRCP-DTKHDVYSFAIVIWGILTQKKP 198
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 353 FIDDYILtLHRKIKNEAVVFPEEPEVSE-------DLKDLILRMLDKNPETRIGVSDIKL 405
Cdd:cd14025   199 FAGENNI-LHIMVKVVKGHRPSLSPIPRqrpsecqQMICLMKRCWDQDPRKRPTFQDITS 257
PTKc_Zap-70 cd05115
Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs ...
194-416 4.72e-14

Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Zap-70 is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor (TCR) signaling. Zap-70 binds the phosphorylated ITAM (immunoreceptor tyr activation motif) sequences of the activated TCR zeta-chain through its SH2 domains, leading to its phosphorylation and activation. It then phosphorylates target proteins, which propagate the signals to downstream pathways. Zap-70 is hardly detected in normal peripheral B-cells, but is present in some B-cell malignancies. It is used as a diagnostic marker for chronic lymphocytic leukemia (CLL) as it is associated with the more aggressive subtype of the disease. The Zap-70 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270686 [Multi-domain]  Cd Length: 269  Bit Score: 72.29  E-value: 4.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDdpaEDNLYLVFDLLRKGPVMEVPCDK--PFPEEQARLYLRDIILGLEYLHCQKI 271
Cdd:cd05115    49 DEMMREAQIMHQLDNPYIVRMIGVCE---AEALMLVMEMASGGPLNKFLSGKkdEITVSNVVELMHQVSMGMKYLEEKNF 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 272 VHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSS-TAGT-P-AFMAPEAIsdSGQSFSGKAlDVWATGVTLY-CFV 347
Cdd:cd05115   126 VHRDLAARNVLLVNQHYAKISDFGLSKALGADDSYYKArSAGKwPlKWYAPECI--NFRKFSSRS-DVWSYGVTMWeAFS 202
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 348 YGKCPFiddyiltlhRKIKN-EAVVFPEEPEvsedlkdlilrMLDKNPETRIGVSDIKLHPWVTKHGEEP 416
Cdd:cd05115   203 YGQKPY---------KKMKGpEVMSFIEQGK-----------RMDCPAECPPEMYALMSDCWIYKWEDRP 252
PTKc_Src cd05071
Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the ...
194-397 4.80e-14

Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src (or c-Src) is a cytoplasmic (or non-receptor) PTK, containing an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region with a conserved tyr. It is activated by autophosphorylation at the tyr kinase domain, and is negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). c-Src is the vertebrate homolog of the oncogenic protein (v-Src) from Rous sarcoma virus. Together with other Src subfamily proteins, it is involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Src also play a role in regulating cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Elevated levels of Src kinase activity have been reported in a variety of human cancers. Several inhibitors of Src have been developed as anti-cancer drugs. Src is also implicated in acute inflammatory responses and osteoclast function. The Src subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270656 [Multi-domain]  Cd Length: 277  Bit Score: 72.41  E-value: 4.80e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLddpAEDNLYLVFDLLRKGPVMEvpcdkpFPEEQARLYLR---------DIILGLE 264
Cdd:cd05071    49 EAFLQEAQVMKKLRHEKLVQLYAVV---SEEPIYIVTEYMSKGSLLD------FLKGEMGKYLRlpqlvdmaaQIASGMA 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 265 YLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAISDSgqSFSGKAlDVWATGVTL 343
Cdd:cd05071   120 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPiKWTAPEAALYG--RFTIKS-DVWSFGILL 196
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 344 YCFVY-GKCPfiddYILTLHRKIKNE---AVVFPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd05071   197 TELTTkGRVP----YPGMVNREVLDQverGYRMPCPPECPESLHDLMCQCWRKEPEER 250
PTZ00024 PTZ00024
cyclin-dependent protein kinase; Provisional
196-418 4.95e-14

cyclin-dependent protein kinase; Provisional


Pssm-ID: 240233 [Multi-domain]  Cd Length: 335  Bit Score: 73.26  E-value: 4.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 196 VYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLrKGPVMEVPCDKP-FPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:PTZ00024   67 TLRELKIMNEIKHENIMGLVDVYVE--GDFINLVMDIM-ASDLKKVVDRKIrLTESQVKCILLQILNGLNVLHKWYFMHR 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQFeGNDA---------------QLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWAT 339
Cdd:PTZ00024  144 DLSPANIFINSKGICKIADFGLARRY-GYPPysdtlskdetmqrreEMTSKVVTLWYRAPELL--MGAEKYHFAVDMWSV 220
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 340 GVTLYCFVYGKCPF-----IDD------------------------YILTLHRKIKNEAVVFPEEpevSEDLKDLILRML 390
Cdd:PTZ00024  221 GCIFAELLTGKPLFpgeneIDQlgrifellgtpnednwpqakklplYTEFTPRKPKDLKTIFPNA---SDDAIDLLQSLL 297
                         250       260
                  ....*....|....*....|....*...
gi 1384865967 391 DKNPETRIGVSDIKLHPWVTkhgEEPLP 418
Cdd:PTZ00024  298 KLNPLERISAKEALKHEYFK---SDPLP 322
STKc_MAP3K8 cd13995
Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) ...
176-406 5.28e-14

Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K8 is also called Tumor progression locus 2 (Tpl2) or Cancer Osaka thyroid (Cot), and was first identified as a proto-oncogene in T-cell lymphoma induced by MoMuL virus and in breast carcinoma induced by MMTV. Activated MAP3K8 induces various MAPK pathways including Extracellular Regulated Kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), and p38. It plays a pivotal role in innate immunity, linking Toll-like receptors to the production of TNF and the activation of ERK in macrophages. It is also required in interleukin-1beta production and is critical in host defense against Gram-positive bacteria. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K8 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270897 [Multi-domain]  Cd Length: 256  Bit Score: 71.96  E-value: 5.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 176 PRGS---------QATQGGPAKQLLPLERVY-QEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVME-VPCD 244
Cdd:cd13995    13 PRGAfgkvylaqdTKTKKRMACKLIPVEQFKpSDVEIQACFRHENIAELYGAL--LWEETVHLFMEAGEGGSVLEkLESC 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 245 KPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVkIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISD 324
Cdd:cd13995    91 GPMREFEIIWVTKHVLKGLDFLHSKNIIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYVPKDLRGTEIYMSPEVILC 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 325 SGQSFSGkalDVWATGVTLYCFVYGKCPFIDDYILTLHRK----IKNEAVVFPEEPE-VSEDLKDLILRMLDKNPETRIG 399
Cdd:cd13995   170 RGHNTKA---DIYSLGATIIHMQTGSPPWVRRYPRSAYPSylyiIHKQAPPLEDIAQdCSPAMRELLEAALERNPNHRSS 246

                  ....*..
gi 1384865967 400 VSDIKLH 406
Cdd:cd13995   247 AAELLKH 253
STKc_CK2_alpha cd14132
Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the ...
101-353 5.37e-14

Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK2 is a tetrameric protein with two catalytic (alpha) and two regulatory (beta) subunits. It is constitutively active and ubiquitously expressed, and is found in the cytoplasm, nucleus, as well as in the plasma membrane. It phosphorylates a wide variety of substrates including gylcogen synthase, cell cycle proteins, nuclear proteins (e.g. DNA topoisomerase II), and ion channels (e.g. ENaC), among others. It may be considered a master kinase controlling the activity or lifespan of many other kinases and exerting its effect over cell fate, gene expression, protein synthesis and degradation, and viral infection. CK2 is implicated in every stage of the cell cycle and is required for cell cycle progression. It plays crucial roles in cell differentiation, proliferation, and survival, and is thus implicated in cancer. CK2 is not an oncogene by itself but elevated CK2 levels create an environment that enhances the survival of tumor cells. The CK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271034 [Multi-domain]  Cd Length: 306  Bit Score: 72.57  E-value: 5.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 101 PRSWRRPtiESHRVAISDTEDcvqlnqYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrppprgsq 180
Cdd:cd14132     1 PPEYWDY--ENLNVEWGSQDD------YEIIRKIGRGKYSEVFEGINIGNNEKVVI------------------------ 48
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 181 atqggpaKQLLPL--ERVYQEIAILKKL-DHVNVVKLIEVLDDPAEDNLYLVFDllrkgpvmEVPCDKP---FP---EEQ 251
Cdd:cd14132    49 -------KVLKPVkkKKIKREIKILQNLrGGPNIVKLLDVVKDPQSKTPSLIFE--------YVNNTDFktlYPtltDYD 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 252 ARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGH-VKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAISDSGQ-SF 329
Cdd:cd14132   114 IRYYMYELLKALDYCHSKGIMHRDVKPHNIMIDHEKRkLRLIDWGLA-EFYHPGQEYNVRVASRYYKGPELLVDYQYyDY 192
                         250       260
                  ....*....|....*....|....
gi 1384865967 330 SgkaLDVWATGVTLYCFVYGKCPF 353
Cdd:cd14132   193 S---LDMWSLGCMLASMIFRKEPF 213
PTKc_Abl cd05052
Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of ...
191-353 6.27e-14

Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Abl (or c-Abl) is a ubiquitously-expressed cytoplasmic (or nonreceptor) PTK that contains SH3, SH2, and tyr kinase domains in its N-terminal region, as well as nuclear localization motifs, a putative DNA-binding domain, and F- and G-actin binding domains in its C-terminal tail. It also contains a short autoinhibitory cap region in its N-terminus. Abl function depends on its subcellular localization. In the cytoplasm, Abl plays a role in cell proliferation and survival. In response to DNA damage or oxidative stress, Abl is transported to the nucleus where it induces apoptosis. In chronic myelogenous leukemia (CML) patients, an aberrant translocation results in the replacement of the first exon of Abl with the BCR (breakpoint cluster region) gene. The resulting BCR-Abl fusion protein is constitutively active and associates into tetramers, resulting in a hyperactive kinase sending a continuous signal. This leads to uncontrolled proliferation, morphological transformation and anti-apoptotic effects. BCR-Abl is the target of selective inhibitors, such as imatinib (Gleevec), used in the treatment of CML. Abl2, also known as ARG (Abelson-related gene), is thought to play a cooperative role with Abl in the proper development of the nervous system. The Tel-ARG fusion protein, resulting from reciprocal translocation between chromosomes 1 and 12, is associated with acute myeloid leukemia (AML). The TEL gene is a frequent fusion partner of other tyr kinase oncogenes, including Tel/Abl, Tel/PDGFRbeta, and Tel/Jak2, found in patients with leukemia and myeloproliferative disorders. The Abl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270645 [Multi-domain]  Cd Length: 263  Bit Score: 71.68  E-value: 6.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 191 LPLERVYQEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYL-RDIILGLEYLH 267
Cdd:cd05052    44 MEVEEFLKEAAVMKEIKHPNLVQLLGVCT--REPPFYIITEFMPYGNLLDYlrECNREELNAVVLLYMaTQIASAMEYLE 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 268 CQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAISDSgqSFSGKAlDVWATGVTLY-C 345
Cdd:cd05052   122 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPiKWTAPESLAYN--KFSIKS-DVWAFGVLLWeI 198

                  ....*...
gi 1384865967 346 FVYGKCPF 353
Cdd:cd05052   199 ATYGMSPY 206
PKc_MEK cd06615
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
259-352 7.17e-14

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 and MEK2 are MAPK kinases (MAPKKs or MKKs), and are dual-specificity PKs that phosphorylate and activate the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1/2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. This cascade has also been implicated in synaptic plasticity, migration, morphological determination, and stress response immunological reactions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1/2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132946 [Multi-domain]  Cd Length: 308  Bit Score: 72.47  E-value: 7.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 259 IILGLEYLHCQ-KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFegNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVW 337
Cdd:cd06615   108 VLRGLTYLREKhKIMHRDVKPSNILVNSRGEIKLCDFGVSGQL--IDSMANSFVGTRSYMSPERL--QGTHYTVQS-DIW 182
                          90
                  ....*....|....*
gi 1384865967 338 ATGVTLYCFVYGKCP 352
Cdd:cd06615   183 SLGLSLVEMAIGRYP 197
STKc_TGFbR-like cd13998
Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; ...
262-388 7.65e-14

Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. There are two types of TGFbeta receptors included in this subfamily, I and II, that play different roles in signaling. For signaling to occur, the ligand first binds to the high-affinity type II receptor, which is followed by the recruitment of the low-affinity type I receptor to the complex and its activation through trans-phosphorylation by the type II receptor. The active type I receptor kinase starts intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. Different ligands interact with various combinations of types I and II receptors to elicit a specific signaling pathway. Activins primarily signal through combinations of ACVR1b/ALK7 and ACVR2a/b; myostatin and GDF11 through TGFbR1/ALK4 and ACVR2a/b; BMPs through ACVR1/ALK1 and BMPR2; and TGFbeta through TGFbR1 and TGFbR2. The TGFbR-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270900 [Multi-domain]  Cd Length: 289  Bit Score: 72.09  E-value: 7.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLHCQ---------KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQL----SSTAGTPAFMAPEAISDS--- 325
Cdd:cd13998   104 GLAHLHSEipgctqgkpAIAHRDLKSKNILVKNDGTCCIADFGLAVRLSPSTGEEdnanNGQVGTKRYMAPEVLEGAinl 183
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 326 --GQSFsgKALDVWATGVTLY-----CFVyGKCPfIDDYILTLHRKIkneavvfPEEPEVsEDLKDLILR 388
Cdd:cd13998   184 rdFESF--KRVDIYAMGLVLWemasrCTD-LFGI-VEEYKPPFYSEV-------PNHPSF-EDMQEVVVR 241
PHA03209 PHA03209
serine/threonine kinase US3; Provisional
199-377 7.71e-14

serine/threonine kinase US3; Provisional


Pssm-ID: 177557 [Multi-domain]  Cd Length: 357  Bit Score: 72.99  E-value: 7.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPAEDNLYL------VFDLLRKGpvmevpcDKPFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:PHA03209  107 EAMLLQNVNHPSVIRMKDTLVSGAITCMVLphyssdLYTYLTKR-------SRPLPIDQALIIEKQILEGLRYLHAQRII 179
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFGVSnQFEGNDAQLSSTAGTPAFMAPEAISDSgqSFSGKAlDVWATGVTLY-CFVYGKC 351
Cdd:PHA03209  180 HRDVKTENIFINDVDQVCIGDLGAA-QFPVVAPAFLGLAGTVETNAPEVLARD--KYNSKA-DIWSAGIVLFeMLAYPST 255
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1384865967 352 PFID------DYILTLH-------RKIKNEAVVFPEEPE 377
Cdd:PHA03209  256 IFEDppstpeEYVKSCHshllkiiSTLKVHPEEFPRDPG 294
PTKc_EGFR_like cd05057
Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs ...
194-353 7.77e-14

Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. Gain of function alterations, through their overexpression, deletions, or point mutations in their kinase domains, have been implicated in various cancers. These receptors are targets of many small molecule inhibitors and monoclonal antibodies used in cancer therapy. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270648 [Multi-domain]  Cd Length: 279  Bit Score: 71.68  E-value: 7.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPaedNLYLVFDLLRKGPVMEVpcdkpFPEEQARL-------YLRDIILGLEYL 266
Cdd:cd05057    54 EEILDEAYVMASVDHPHLVRLLGICLSS---QVQLITQLMPLGCLLDY-----VRNHRDNIgsqlllnWCVQIAKGMSYL 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 267 HCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG-TP-AFMAPEAISDsgQSFSGKAlDVWATGVTLY 344
Cdd:cd05057   126 EEKRLVHRDLAARNVLVKTPNHVKITDFGLAKLLDVDEKEYHAEGGkVPiKWMALESIQY--RIYTHKS-DVWSYGVTVW 202
                         170
                  ....*....|
gi 1384865967 345 -CFVYGKCPF 353
Cdd:cd05057   203 eLMTFGAKPY 212
STKc_SBK1 cd13987
Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the ...
248-408 9.76e-14

Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SBK1, also called BSK146, is predominantly expressed in the brain. Its expression is increased in the developing brain during the late embryonic stage, coinciding with dramatic neuronal proliferation, migration, and maturation. SBK1 may play an important role in regulating brain development. The SBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270889 [Multi-domain]  Cd Length: 259  Bit Score: 71.20  E-value: 9.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 248 PEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDG--HVKIADFGVSNQfegNDAQLSSTAGTPAFMAPEaISDS 325
Cdd:cd13987    89 PEERVKRCAAQLASALDFMHSKNLVHRDIKPENVLLFDKDcrRVKLCDFGLTRR---VGSTVKRVSGTIPYTAPE-VCEA 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 326 G--QSFS-GKALDVWATGVTLYCFVYG---------KCPFIDDYILTLHRkiKNEAVvfpeePEVSEDLKDLILRMLDK- 392
Cdd:cd13987   165 KknEGFVvDPSIDVWAFGVLLFCCLTGnfpwekadsDDQFYEEFVRWQKR--KNTAV-----PSQWRRFTPKALRMFKKl 237
                         170       180
                  ....*....|....*....|..
gi 1384865967 393 ---NPETRIGVSDIKL---HPW 408
Cdd:cd13987   238 lapEPERRCSIKEVFKylgDRW 259
STKc_IKK_beta cd14038
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
194-382 1.48e-13

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKbeta is involved in the classical pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The classical pathway regulates the majority of genes activated by NF-kB including those encoding cytokines, chemokines, leukocyte adhesion molecules, and anti-apoptotic factors. It involves NEMO (NF-kB Essential MOdulator)- and IKKbeta-dependent phosphorylation and degradation of the Inhibitor of NF-kB (IkB), which liberates NF-kB dimers (typified by the p50-p65 heterodimer) from an inactive IkB/dimeric NF-kB complex, enabling them to migrate to the nucleus where they regulate gene transcription. The IKKbeta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270940 [Multi-domain]  Cd Length: 290  Bit Score: 71.15  E-value: 1.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEV---LDDPAEDNLYLVF-------DLLRKGPVMEVPCDkpFPEEQARLYLRDIILGL 263
Cdd:cd14038    37 ERWCLEIQIMKRLNHPNVVAARDVpegLQKLAPNDLPLLAmeycqggDLRKYLNQFENCCG--LREGAILTLLSDISSAL 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 264 EYLHCQKIVHRDIKPSNLLL--GDDGHV-KIADFGVSNQFEgNDAQLSSTAGTPAFMAPEAISdsgQSFSGKALDVWATG 340
Cdd:cd14038   115 RYLHENRIIHRDLKPENIVLqqGEQRLIhKIIDLGYAKELD-QGSLCTSFVGTLQYLAPELLE---QQKYTVTVDYWSFG 190
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1384865967 341 VTLYCFVYGKCPFIDDY-ILTLHRKIKNEAVvfpEEPEVSEDL 382
Cdd:cd14038   191 TLAFECITGFRPFLPNWqPVQWHGKVRQKSN---EDIVVYEDL 230
PKc_TOPK cd14001
Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer ...
185-344 1.79e-13

Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TOPK, also called PDZ-binding kinase (PBK), is activated at the early stage of mitosis and plays a critical role in cytokinesis. It partly functions as a mitogen-activated protein kinase (MAPK) kinase and is capable of phosphorylating p38, JNK1, and ERK2. TOPK also plays a role in DNA damage sensing and repair through its phosphorylation of histone H2AX. It contributes to cancer development and progression by downregulating the function of tumor suppressor p53 and reducing cell-cycle regulatory proteins. TOPK is found highly expressed in breast and skin cancer cells. The TOPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270903 [Multi-domain]  Cd Length: 292  Bit Score: 70.89  E-value: 1.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 185 GPAKQLLPLERVYQEIAILKKLDHVNVVKLiEVLDDPAEDNLYLV--------FDLLRKGPVMEvpcDKPFPEEQARLYL 256
Cdd:cd14001    41 DKGQRSLYQERLKEEAKILKSLNHPNIVGF-RAFTKSEDGSLCLAmeyggkslNDLIEERYEAG---LGPFPAATILKVA 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 257 RDIILGLEYLHCQK-IVHRDIKPSNLLL-GDDGHVKIADFGVSNQFEGNDAQLSST----AGTPAFMAPEAISDSGqSFS 330
Cdd:cd14001   117 LSIARALEYLHNEKkILHGDIKSGNVLIkGDFESVKLCDFGVSLPLTENLEVDSDPkaqyVGTEPWKAKEALEEGG-VIT 195
                         170
                  ....*....|....
gi 1384865967 331 GKAlDVWATGVTLY 344
Cdd:cd14001   196 DKA-DIFAYGLVLW 208
STKc_IRAK4 cd14158
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; ...
198-353 2.14e-13

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK4 plays a critical role in NFkB activation by its interaction with MyD88, which acts as a scaffold that enables IRAK4 to phosphorylate and activate IRAK1 and/or IRAK2. It also plays an important role in type I IFN production induced by TLR7/8/9. The IRAK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271060 [Multi-domain]  Cd Length: 288  Bit Score: 70.61  E-value: 2.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVME-VPC--DKPFPEEQARLYL-RDIILGLEYLHCQKIVH 273
Cdd:cd14158    63 QEIQVMAKCQHENLVELLGYSCDG--PQLCLVYTYMPNGSLLDrLAClnDTPPLSWHMRCKIaQGTANGINYLHENNHIH 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLgDDGHV-KIADFGVSNQfEGNDAQLSST---AGTPAFMAPEAISdsgQSFSGKaLDVWATGVTLYCFVYG 349
Cdd:cd14158   141 RDIKSANILL-DETFVpKISDFGLARA-SEKFSQTIMTeriVGTTAYMAPEALR---GEITPK-SDIFSFGVVLLEIITG 214

                  ....
gi 1384865967 350 KCPF 353
Cdd:cd14158   215 LPPV 218
PKc_CLK cd14134
Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases; Dual-specificity ...
126-408 2.30e-13

Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on S/T residues. In Drosophila, the CLK homolog DOA (Darkener of apricot) is essential for embryogenesis and its mutation leads to defects in sexual differentiation, eye formation, and neuronal development. In fission yeast, the CLK homolog Lkh1 is a negative regulator of filamentous growth and asexual flocculation, and is also involved in oxidative stress response. Vertebrates contain mutliple CLK proteins and mammals have four (CLK1-4). The CLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271036 [Multi-domain]  Cd Length: 332  Bit Score: 71.06  E-value: 2.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLskkkllkqygfprRPPPRGSQAtqggpAKqllpLE-RVYQEIAILK 204
Cdd:cd14134    12 NRYKILRLLGEGTFGKVLECWDRKRKRYVAVKII-------------RNVEKYREA-----AK----IEiDVLETLAEKD 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDdpAEDNLYLVFDLLrkGP----VMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSN 280
Cdd:cd14134    70 PNGKSHCVQLRDWFD--YRGHMCIVFELL--GPslydFLKKNNYGPFPLEHVQHIAKQLLEAVAFLHDLKLTHTDLKPEN 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 281 LLLGD-------------------DGHVKIADFGvSNQFEgnDAQLSSTAGTPAFMAPEAISDSGQSFSGkalDVWATGV 341
Cdd:cd14134   146 ILLVDsdyvkvynpkkkrqirvpkSTDIKLIDFG-SATFD--DEYHSSIVSTRHYRAPEVILGLGWSYPC---DVWSIGC 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 342 TLYCFVYGKCPF------------------IDDYILtlhRKIKNEA---------VVFPEEP-------EVSEDLK---- 383
Cdd:cd14134   220 ILVELYTGELLFqthdnlehlammerilgpLPKRMI---RRAKKGAkyfyfyhgrLDWPEGSssgrsikRVCKPLKrlml 296
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1384865967 384 ----------DLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14134   297 lvdpehrllfDLIRKMLEYDPSKRITAKEALKHPF 331
PTKc_Wee1_fungi cd14052
Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the ...
193-407 2.42e-13

Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of fungal Wee1 proteins, also called Swe1 in budding yeast and Mik1 in fission yeast. Yeast Wee1 is required to control cell size. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The fungal Wee1 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270954 [Multi-domain]  Cd Length: 278  Bit Score: 70.14  E-value: 2.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLD---HVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVmevpcdKPFPEEQARL----------YLRDI 259
Cdd:cd14052    44 RLRRLEEVSILRELTldgHDNIVQLIDSWEY--HGHLYIQTELCENGSL------DVFLSELGLLgrldefrvwkILVEL 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 260 ILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFG------VSNQFEGNdaqlsstaGTPAFMAPEAISDsgqSFSGKA 333
Cdd:cd14052   116 SLGLRFIHDHHFVHLDLKPANVLITFEGTLKIGDFGmatvwpLIRGIERE--------GDREYIAPEILSE---HMYDKP 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 334 LDVWATGVTLYCFV-------------------YGKCPFIddYILTLH---RKIKNEAVVFPEEPEVSEDLKDLILRMLD 391
Cdd:cd14052   185 ADIFSLGLILLEAAanvvlpdngdawqklrsgdLSDAPRL--SSTDLHsasSPSSNPPPDPPNMPILSGSLDRVVRWMLS 262
                         250
                  ....*....|....*.
gi 1384865967 392 KNPETRIGVSDIKLHP 407
Cdd:cd14052   263 PEPDRRPTADDVLATP 278
PKc_MEK1 cd06650
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
259-352 2.70e-13

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. MEK1 also plays a role in cell cycle control. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270816 [Multi-domain]  Cd Length: 319  Bit Score: 70.85  E-value: 2.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 259 IILGLEYLHCQ-KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEgnDAQLSSTAGTPAFMAPEAIsdSGQSFSGKAlDVW 337
Cdd:cd06650   112 VIKGLTYLREKhKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERL--QGTHYSVQS-DIW 186
                          90
                  ....*....|....*
gi 1384865967 338 ATGVTLYCFVYGKCP 352
Cdd:cd06650   187 SMGLSLVEMAVGRYP 201
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
124-353 2.89e-13

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 72.46  E-value: 2.89e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  124 QLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKkkllkqygfprrpppRGSQATQggpAKQLLplervyQEIAIL 203
Cdd:PTZ00266    11 RLNEYEVIKKIGNGRFGEVFLVKHKRTQEFFCWKAISY---------------RGLKERE---KSQLV------IEVNVM 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  204 KKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME--VPCDKPFP--EEQARLYL-RDIILGLEYLH-------CQKI 271
Cdd:PTZ00266    67 RELKHKNIVRYIDRFLNKANQKLYILMEFCDAGDLSRniQKCYKMFGkiEEHAIVDItRQLLHALAYCHnlkdgpnGERV 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967  272 VHRDIKPSNLLLGDD-GHV----------------KIADFGVSNQFeGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKAl 334
Cdd:PTZ00266   147 LHRDLKPQNIFLSTGiRHIgkitaqannlngrpiaKIGDFGLSKNI-GIESMAHSCVGTPYYWSPELLLHETKSYDDKS- 224
                          250
                   ....*....|....*....
gi 1384865967  335 DVWATGVTLYCFVYGKCPF 353
Cdd:PTZ00266   225 DMWALGCIIYELCSGKTPF 243
PTKc_Itk cd05112
Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs ...
126-353 3.68e-13

Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Itk, also known as Tsk or Emt, is a member of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Itk contains the Tec homology (TH) domain containing one proline-rich region and a zinc-binding region. Itk is expressed in T-cells and mast cells, and is important in their development and differentiation. Of the three Tec kinases expressed in T-cells, Itk plays the predominant role in T-cell receptor (TCR) signaling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization. It also plays a role in the downstream signaling of the T-cell costimulatory receptor CD28, the T-cell surface receptor CD2, and the chemokine receptor CXCR4. In addition, Itk is crucial for the development of T-helper(Th)2 effector responses. The Itk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133243 [Multi-domain]  Cd Length: 256  Bit Score: 69.59  E-value: 3.68e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNEsEDRHYAMKVLskkkllkQYGFprrppprgsqatqggpakqlLPLERVYQEIAILKK 205
Cdd:cd05112     4 SELTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTI-------REGA--------------------MSEEDFIEEAEVMMK 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGPVMEVPCDK--PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd05112    56 LSHPKLVQLYGVCLEQAP--ICLVFEFMEHGCLSDYLRTQrgLFSAETLLGMCLDVCEGMAYLEEASVIHRDLAARNCLV 133
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 284 GDDGHVKIADFGVSnQFEGNDaQLSSTAGTP---AFMAPEAISDSgqSFSGKAlDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05112   134 GENQVVKVSDFGMT-RFVLDD-QYTSSTGTKfpvKWSSPEVFSFS--RYSSKS-DVWSFGVLMWeVFSEGKIPY 202
PTKc_Axl cd05075
Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the ...
193-397 3.85e-13

Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Axl is widely expressed in a variety of organs and cells including epithelial, mesenchymal, hematopoietic, as well as non-transformed cells. It is important in many cellular functions such as survival, anti-apoptosis, proliferation, migration, and adhesion. Axl was originally isolated from patients with chronic myelogenous leukemia and a chronic myeloproliferative disorder. It is overexpressed in many human cancers including colon, squamous cell, thyroid, breast, and lung carcinomas. Axl is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to its ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Axl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270660 [Multi-domain]  Cd Length: 277  Bit Score: 69.65  E-value: 3.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLY----LVFDLLRKGPVMEVPC-----DKP--FPEEQARLYLRDIIL 261
Cdd:cd05075    45 MEDFLSEAVCMKEFDHPNVMRLIGVCLQNTESEGYpspvVILPFMKHGDLHSFLLysrlgDCPvyLPTQMLVKFMTDIAS 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ-FEGNDAQLSSTAGTPA-FMAPEAISDsgQSFSGKAlDVWAT 339
Cdd:cd05075   125 GMEYLSSKNFIHRDLAARNCMLNENMNVCVADFGLSKKiYNGDYYRQGRISKMPVkWIAIESLAD--RVYTTKS-DVWSF 201
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 340 GVTLY-CFVYGKCPF-------IDDYILTLHRkikneavvFPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd05075   202 GVTMWeIATRGQTPYpgvenseIYDYLRQGNR--------LKQPPDCLDGLYELMSSCWLLNPKDR 259
STK_BAK1_like cd14664
Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; ...
199-353 4.51e-13

Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes three leucine-rich repeat receptor-like kinases (LRR-RLKs): Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1), and Physcomitrella patens CLL1B clavata1-like receptor S/T protein kinase. BAK1 functions in various signaling pathways. It plays a role in BR (brassinosteroid)-regulated plant development as a co-receptor of BRASSINOSTEROID (BR) INSENSITIVE 1 (BRI1), the receptor for BRs, and is required for full activation of BR signaling. It also modulates pathways involved in plant resistance to pathogen infection (pattern-triggered immunity, PTI) and herbivore attack (wound- or herbivore feeding-induced accumulation of jasmonic acid (JA) and JA-isoleucine. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The STK_BAK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271134 [Multi-domain]  Cd Length: 270  Bit Score: 69.45  E-value: 4.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPaEDNLyLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIIL-----GLEYLH--CQ-K 270
Cdd:cd14664    40 EIQTLGMIRHRNIVRLRGYCSNP-TTNL-LVYEYMPNGSLGELLHSRPESQPPLDWETRQRIAlgsarGLAYLHhdCSpL 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQ-LSSTAGTPAFMAPEAISdsgqsfSGKA---LDVWATGVTLYCF 346
Cdd:cd14664   118 IIHRDVKSNNILLDEEFEAHVADFGLAKLMDDKDSHvMSSVAGSYGYIAPEYAY------TGKVsekSDVYSYGVVLLEL 191

                  ....*..
gi 1384865967 347 VYGKCPF 353
Cdd:cd14664   192 ITGKRPF 198
PTKc_Src_Fyn_like cd14203
Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
194-397 5.19e-13

Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes a subset of Src-like PTKs including Src, Fyn, Yrk, and Yes, which are all widely expressed. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. They are also implicated in acute inflammatory responses and osteoclast function. The Src/Fyn-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271105 [Multi-domain]  Cd Length: 248  Bit Score: 68.79  E-value: 5.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLddpAEDNLYLVFDLLRKGPVMEvpcdkpFPEEQARLYLR---------DIILGLE 264
Cdd:cd14203    35 EAFLEEAQIMKKLRHDKLVQLYAVV---SEEPIYIVTEFMSKGSLLD------FLKDGEGKYLKlpqlvdmaaQIASGMA 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 265 YLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAiSDSGQsFSGKAlDVWATGVTL 343
Cdd:cd14203   106 YIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPiKWTAPEA-ALYGR-FTIKS-DVWSFGILL 182
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 344 YCFVY-GKCPfiddYILTLHRKIKNE---AVVFPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd14203   183 TELVTkGRVP----YPGMNNREVLEQverGYRMPCPPGCPESLHELMCQCWRKDPEER 236
PTKc_Tec_like cd05059
Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
198-353 5.38e-13

Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Tec-like subfamily is composed of Tec, Btk, Bmx (Etk), Itk (Tsk, Emt), Rlk (Txk), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, some members contain the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. Tec kinases form the second largest subfamily of nonreceptor PTKs and are expressed mainly by haematopoietic cells, although Tec and Bmx are also found in endothelial cells. B-cells express Btk and Tec, while T-cells express Itk, Txk, and Tec. Collectively, Tec kinases are expressed in a variety of myeloid cells such as mast cells, platelets, macrophages, and dendritic cells. Each Tec kinase shows a distinct cell-type pattern of expression. Tec kinases play important roles in the development, differentiation, maturation, regulation, survival, and function of B-cells and T-cells. Mutations in Btk cause the severe B-cell immunodeficiency, X-linked agammaglobulinaemia (XLA). The Tec-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173637 [Multi-domain]  Cd Length: 256  Bit Score: 69.01  E-value: 5.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGpvmevpCDKPFPEEQARLYLRDIIL--------GLEYLHCQ 269
Cdd:cd05059    48 EEAKVMMKLSHPKLVQLYGVCTKQRP--IFIVTEYMANG------CLLNYLRERRGKFQTEQLLemckdvceAMEYLESN 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 270 KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEgnDAQLSSTAGTP---AFMAPEAISDSgqSFSGKAlDVWATGVTLY-C 345
Cdd:cd05059   120 GFIHRDLAARNCLVGEQNVVKVSDFGLARYVL--DDEYTSSVGTKfpvKWSPPEVFMYS--KFSSKS-DVWSFGVLMWeV 194

                  ....*...
gi 1384865967 346 FVYGKCPF 353
Cdd:cd05059   195 FSEGKMPY 202
PTKc_Csk cd05082
Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the ...
199-353 5.65e-13

Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Csk is expressed in a wide variety of tissues. As a negative regulator of Src, Csk plays a role in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Csk is a cytoplasmic (or nonreceptor) PTK containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases, Csk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. In addition, Csk also shows Src-independent functions. It is a critical component in G-protein signaling, and plays a role in cytoskeletal reorganization and cell migration. The Csk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133213 [Multi-domain]  Cd Length: 256  Bit Score: 68.85  E-value: 5.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLddpAEDN--LYLVFDLLRKGPVMEvpcdkpFPEEQARLYL---------RDIILGLEYLH 267
Cdd:cd05082    49 EASVMTQLRHSNLVQLLGVI---VEEKggLYIVTEYMAKGSLVD------YLRSRGRSVLggdcllkfsLDVCEAMEYLE 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 268 CQKIVHRDIKPSNLLLGDDGHVKIADFGVSNqfEGNDAQlsSTAGTPA-FMAPEAISDsgQSFSGKAlDVWATGVTLY-C 345
Cdd:cd05082   120 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTK--EASSTQ--DTGKLPVkWTAPEALRE--KKFSTKS-DVWSFGILLWeI 192

                  ....*...
gi 1384865967 346 FVYGKCPF 353
Cdd:cd05082   193 YSFGRVPY 200
STKc_WNK2_like cd14032
Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the ...
191-408 6.55e-13

Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK2 is widely expressed and has been shown to be epigenetically silenced in gliomas. It inhibits cell growth by acting as a negative regulator of MEK1-ERK1/2 signaling. WNK2 modulates growth factor-induced cancer cell proliferation, suggesting that it may be a tumor suppressor gene. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. The WNK2-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270934 [Multi-domain]  Cd Length: 266  Bit Score: 68.95  E-value: 6.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 191 LPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDN--LYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLH 267
Cdd:cd14032    42 VERQRFKEEAEMLKGLQHPNIVRFYDFWESCAKGKrcIVLVTELMTSGTLKTyLKRFKVMKPKVLRSWCRQILKGLLFLH 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 268 CQK--IVHRDIKPSNLLL-GDDGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAIsdsgQSFSGKALDVWATGVTLY 344
Cdd:cd14032   122 TRTppIIHRDLKCDNIFItGPTGSVKIGDLGLATLKRASFAK--SVIGTPEFMAPEMY----EEHYDESVDVYAFGMCML 195
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 345 CFVYGKCPFID-DYILTLHRK----IKNEAVVFPEEPEVSEDLKDLILrmldKNPETRIGVSDIKLHPW 408
Cdd:cd14032   196 EMATSEYPYSEcQNAAQIYRKvtcgIKPASFEKVTDPEIKEIIGECIC----KNKEERYEIKDLLSHAF 260
STKc_RPK118_like cd05576
Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins; STKs catalyze ...
248-408 7.84e-13

Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RPK118 contains an N-terminal Phox homology (PX) domain, a Microtubule Interacting and Trafficking (MIT) domain, and a kinase domain containing a long uncharacterized insert. Also included in the family is human RPK60 (or ribosomal protein S6 kinase-like 1), which also contains MIT and kinase domains but lacks a PX domain. RPK118 binds sphingosine kinase, a key enzyme in the synthesis of sphingosine 1-phosphate (SPP), a lipid messenger involved in many cellular events. RPK118 may be involved in transmitting SPP-mediated signaling. RPK118 also binds the antioxidant peroxiredoxin-3. RPK118 may be involved in the transport of PRDX3 from the cytoplasm to its site of function in the mitochondria. The RPK118-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270728 [Multi-domain]  Cd Length: 265  Bit Score: 68.73  E-value: 7.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 248 PEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEgndAQLSSTAGTPAFMAPE--AISDS 325
Cdd:cd05576   111 PEECIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVE---DSCDSDAIENMYCAPEvgGISEE 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 326 GQsfsgkALDVWATGVTLYCFVYGKcPFIDDYILTLHRkikNEAVVFPEepEVSEDLKDLILRMLDKNPETRI-----GV 400
Cdd:cd05576   188 TE-----ACDWWSLGALLFELLTGK-ALVECHPAGINT---HTTLNIPE--WVSEEARSLLQQLLQFNPTERLgagvaGV 256

                  ....*...
gi 1384865967 401 SDIKLHPW 408
Cdd:cd05576   257 EDIKSHPF 264
STKc_PFTAIRE1 cd07869
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer ...
198-403 8.09e-13

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-1 is widely expressed except in the spleen and thymus. It is highly expressed in the brain, heart, pancreas, testis, and ovary, and is localized in the cytoplasm. It is regulated by cyclin D3 and is inhibited by the p21 cell cycle inhibitor. It has also been shown to interact with the membrane-associated cyclin Y, which recruits the protein to the plasma membrane. PFTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143374 [Multi-domain]  Cd Length: 303  Bit Score: 68.95  E-value: 8.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEVpcDK---PFPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd07869    52 REASLLKGLKHANIVLLHDIIH--TKETLTLVFEYVHTDLCQYM--DKhpgGLHPENVKLFLFQLLRGLSYIHQRYILHR 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGvtlycfvygkCPFI 354
Cdd:cd07869   128 DLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVL--LGSTEYSTCLDMWGVG----------CIFV 195
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1384865967 355 DdyiltlhrkIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd07869   196 E---------MIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSL 235
pknD PRK13184
serine/threonine-protein kinase PknD;
259-397 8.87e-13

serine/threonine-protein kinase PknD;


Pssm-ID: 183880 [Multi-domain]  Cd Length: 932  Bit Score: 70.95  E-value: 8.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 259 IILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG-NDAQLSSTA-----------------GTPAFMAPE 320
Cdd:PRK13184  122 ICATIEYVHSKGVLHRDLKPDNILLGLFGEVVILDWGAAIFKKLeEEDLLDIDVdernicyssmtipgkivGTPDYMAPE 201
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 321 AISDSGQSfsgKALDVWATGVTLYcfvygkcpfiddYILTLH--------RKIK-NEAVVFPEE--P--EVSEDLKDLIL 387
Cdd:PRK13184  202 RLLGVPAS---ESTDIYALGVILY------------QMLTLSfpyrrkkgRKISyRDVILSPIEvaPyrEIPPFLSQIAM 266
                         170
                  ....*....|
gi 1384865967 388 RMLDKNPETR 397
Cdd:PRK13184  267 KALAVDPAER 276
STKc_TDY_MAPK cd07859
Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; ...
127-340 9.36e-13

Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TDY subtype and is composed of Group D plant MAPKs including Arabidopsis thaliana MPK18 (AtMPK18), Oryza sativa Blast- and Wound-induced MAPK1 (OsBWMK1), OsWJUMK1 (Wound- and JA-Uninducible MAPK1), Zea mays MPK6, and the Medicago sativa TDY1 gene product. OsBWMK1 enhances resistance to pathogenic infections. It mediates stress-activated defense responses by activating a transcription factor that affects the expression of stress-related genes. AtMPK18 is involved in microtubule-related functions. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20 while Oryza sativa contains at least 17 MAPKs. Arabidopsis thaliana contains more TEY-type MAPKs than TDY-type, whereas the reverse is true for Oryza sativa. The TDY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143364 [Multi-domain]  Cd Length: 338  Bit Score: 69.42  E-value: 9.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKqygfprrppprgSQATqggpakqllpleRVYQEIAILKKL 206
Cdd:cd07859     1 RYKIQEVIGKGSYGVVCSAIDTHTGEKVAIKKINDVFEHV------------SDAT------------RILREIKLLRLL 56
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 DHVNVVKLIEVLDDPAE---DNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd07859    57 RHPDIVEIKHIMLPPSRrefKDIYVVFELMESDLHQVIKANDDLTPEHHQFFLYQLLRALKYIHTANVFHRDLKPKNILA 136
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 284 GDDGHVKIADFGVSnQFEGNDAQ----LSSTAGTPAFMAPEAISdsgqSFSGK---ALDVWATG 340
Cdd:cd07859   137 NADCKLKICDFGLA-RVAFNDTPtaifWTDYVATRWYRAPELCG----SFFSKytpAIDIWSIG 195
PTKc_Hck cd05073
Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the ...
191-397 1.10e-12

Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Hck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Hck is present in myeloid and lymphoid cells that play a role in the development of cancer. It may be important in the oncogenic signaling of the protein Tel-Abl, which induces a chronic myelogenous leukemia (CML)-like disease. Hck also acts as a negative regulator of G-CSF-induced proliferation of granulocytic precursors, suggesting a possible role in the development of acute myeloid leukemia (AML). In addition, Hck is essential in regulating the degranulation of polymorphonuclear leukocytes. Genetic polymorphisms affect the expression level of Hck, which affects PMN mediator release and influences the development of chronic obstructive pulmonary disease (COPD). Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Hck subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270658 [Multi-domain]  Cd Length: 265  Bit Score: 68.13  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 191 LPLERVYQEIAILKKLDHVNVVKLIEVLddpAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARL--YLRDIILGLEYLH 267
Cdd:cd05073    48 MSVEAFLAEANVMKTLQHDKLVKLHAVV---TKEPIYIITEFMAKGSLLDfLKSDEGSKQPLPKLidFSAQIAEGMAFIE 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 268 CQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAISDSgqSFSGKAlDVWATGVTLYCF 346
Cdd:cd05073   125 QRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPiKWTAPEAINFG--SFTIKS-DVWSFGILLMEI 201
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 347 V-YGKCPFID----DYILTLHRKIKneavvFPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd05073   202 VtYGRIPYPGmsnpEVIRALERGYR-----MPRPENCPEELYNIMMRCWKNRPEER 252
PTKc_Lck_Blk cd05067
Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs ...
198-397 1.17e-12

Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lck and Blk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cells and natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling. Blk is expressed specifically in B-cells. It is involved in pre-BCR (B-cell receptor) signaling. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lck/Blk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270652 [Multi-domain]  Cd Length: 264  Bit Score: 67.99  E-value: 1.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLddpAEDNLYLVFDLLRKGPV---MEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd05067    51 AEANLMKQLQHQRLVRLYAVV---TQEPIYIITEYMENGSLvdfLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHR 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAISDSgqSFSGKAlDVWATGVTLYCFV-YGKCP 352
Cdd:cd05067   128 DLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPiKWTAPEAINYG--TFTIKS-DVWSFGILLTEIVtHGRIP 204
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1384865967 353 FID----DYILTLHRKIKneavvFPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd05067   205 YPGmtnpEVIQNLERGYR-----MPRPDNCPEELYQLMRLCWKERPEDR 248
STKc_WNK3 cd14031
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze ...
194-408 1.28e-12

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK3 shows a restricted expression pattern; it is found at high levels in the pituary glands and is also expressed in the kidney and brain. It has been shown to regulate many ion transporters including members of the SLC12A family of cation-chloride cotransporters such as NCC and NKCC2, the renal potassium channel ROMK, and the epithelial calcium channels TRPV5 and TRPV6. WNK3 appears to sense low-chloride hypotonic stress and under these conditions, it activates SPAK, which directly interacts and phosphorylates cation-chloride cotransporters. WNK3 has also been shown to promote cell survival, possibly through interaction with procaspase-3 and HSP70. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270933 [Multi-domain]  Cd Length: 275  Bit Score: 68.21  E-value: 1.28e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDD--PAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQK 270
Cdd:cd14031    54 QRFKEEAEMLKGLQHPNIVRFYDSWESvlKGKKCIVLVTELMTSGTLKTyLKRFKVMKPKVLRSWCRQILKGLQFLHTRT 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 --IVHRDIKPSNLLL-GDDGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAIsdsgQSFSGKALDVWATGVTLYCFV 347
Cdd:cd14031   134 ppIIHRDLKCDNIFItGPTGSVKIGDLGLATLMRTSFAK--SVIGTPEFMAPEMY----EEHYDESVDVYAFGMCMLEMA 207
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 348 YGKCPFID-DYILTLHRK----IKNEAVVFPEEPEVsedlKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14031   208 TSEYPYSEcQNAAQIYRKvtsgIKPASFNKVTDPEV----KEIIEGCIRQNKSERLSIKDLLNHAF 269
PTKc_InsR_like cd05032
Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer ...
197-344 1.41e-12

Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The InsR subfamily is composed of InsR, Insulin-like Growth Factor-1 Receptor (IGF-1R), and similar proteins. InsR and IGF-1R are receptor PTKs (RTKs) composed of two alphabeta heterodimers. Binding of the ligand (insulin, IGF-1, or IGF-2) to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR and IGF-1R, which share 84% sequence identity in their kinase domains, display physiologically distinct yet overlapping functions in cell growth, differentiation, and metabolism. InsR activation leads primarily to metabolic effects while IGF-1R activation stimulates mitogenic pathways. In cells expressing both receptors, InsR/IGF-1R hybrids are found together with classical receptors. Both receptors can interact with common adaptor molecules such as IRS-1 and IRS-2. The InsR-like subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173625 [Multi-domain]  Cd Length: 277  Bit Score: 68.14  E-value: 1.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 197 YQEIAILKKLDHVNVVKLIEVLDD--PAednlYLVFDLLRKG----------PVMEVPCDKPFPE-EQARLYLRDIILGL 263
Cdd:cd05032    57 LNEASVMKEFNCHHVVRLLGVVSTgqPT----LVVMELMAKGdlksylrsrrPEAENNPGLGPPTlQKFIQMAAEIADGM 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 264 EYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ-FEGNDAQLSSTAGTPA-FMAPEAISDSgqSFSGKAlDVWATGV 341
Cdd:cd05032   133 AYLAAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRDiYETDYYRKGGKGLLPVrWMAPESLKDG--VFTTKS-DVWSFGV 209

                  ...
gi 1384865967 342 TLY 344
Cdd:cd05032   210 VLW 212
STKc_WNK4 cd14033
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze ...
194-406 1.48e-12

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK4 shows a restricted expression pattern and is usually found in epithelial cells. It is expressed in nephrons and in extrarenal tissues including intestine, eye, mammary glands, and prostate. WNK4 regulates a variety of ion transport proteins including apical or basolateral ion transporters, ion channels in the transcellular pathway, and claudins in the paracellular pathway. Mutations in WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK4 inhibits the activity of the thiazide-sensitive Na-Cl cotransporter (NCC), which is responsible for about 15% of NaCl reabsorption in the kidney. It also inhibits the renal outer medullary potassium channel (ROMK) and decreases its surface expression. Hypertension and hyperkalemia in PHAII patients with WNK4 mutations may be partly due to increased NaCl reabsorption through NCC and impaired renal potassium secretion by ROMK, respectively. The WNK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270935 [Multi-domain]  Cd Length: 261  Bit Score: 67.72  E-value: 1.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEDN--LYLVFDLLRKGPVMEVPcdKPFPEEQARL---YLRDIILGLEYLH- 267
Cdd:cd14033    45 QRFSEEVEMLKGLQHPNIVRFYDSWKSTVRGHkcIILVTELMTSGTLKTYL--KRFREMKLKLlqrWSRQILKGLHFLHs 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 268 -CQKIVHRDIKPSNLLL-GDDGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAISDSgqsfSGKALDVWATGVTLYC 345
Cdd:cd14033   123 rCPPILHRDLKCDNIFItGPTGSVKIGDLGLATLKRASFAK--SVIGTPEFMAPEMYEEK----YDEAVDVYAFGMCILE 196
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 346 FVYGKCPFID-DYILTLHRKI----KNEAVVFPEEPEVSEDLKDLIlRMldkNPETRIGVSDIKLH 406
Cdd:cd14033   197 MATSEYPYSEcQNAAQIYRKVtsgiKPDSFYKVKVPELKEIIEGCI-RT---DKDERFTIQDLLEH 258
PTKc_TAM cd05035
Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer ...
193-405 1.85e-12

Catalytic Domain of TAM (Tyro3, Axl, Mer) Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The TAM subfamily consists of Tyro3 (or Sky), Axl, Mer (or Mertk), and similar proteins. TAM subfamily members are receptor tyr kinases (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. TAM proteins are implicated in a variety of cellular effects including survival, proliferation, migration, and phagocytosis. They are also associated with several types of cancer as well as inflammatory, autoimmune, vascular, and kidney diseases. The TAM subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270631 [Multi-domain]  Cd Length: 273  Bit Score: 67.56  E-value: 1.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDN------------------LYLVFDLLRKGPvmevpcdKPFPEEQARL 254
Cdd:cd05035    45 IEEFLSEAACMKDFDHPNVMRLIGVCFTASDLNkppspmvilpfmkhgdlhSYLLYSRLGGLP-------EKLPLQTLLK 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 255 YLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ-FEGNDAQLSSTAGTPA-FMAPEAISDsgQSFSGK 332
Cdd:cd05035   118 FMVDIAKGMEYLSNRNFIHRDLAARNCMLDENMTVCVADFGLSRKiYSGDYYRQGRISKMPVkWIALESLAD--NVYTSK 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 333 AlDVWATGVTLY-CFVYGKCPF-------IDDYILTLHRkikneavvFPEEPEVSEDLKDLILRMLDKNPETRIGVSDIK 404
Cdd:cd05035   196 S-DVWSFGVTMWeIATRGQTPYpgvenheIYDYLRNGNR--------LKQPEDCLDEVYFLMYFCWTVDPKDRPTFTKLR 266

                  .
gi 1384865967 405 L 405
Cdd:cd05035   267 E 267
STKc_C-Raf cd14149
Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) ...
199-353 2.68e-12

Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. C-Raf, also known as Raf-1 or c-Raf-1, is ubiquitously expressed and was the first Raf identified. It was characterized as the acquired oncogene from an acutely transforming murine sarcoma virus (3611-MSV) and the transforming agent from the avian retrovirus MH2. C-Raf-deficient mice embryos die around midgestation with increased apoptosis of embryonic tissues, especially in the fetal liver. One of the main functions of C-Raf is restricting caspase activation to promote survival in response to specific stimuli such as Fas stimulation, macrophage apoptosis, and erythroid differentiation. C-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The C-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271051 [Multi-domain]  Cd Length: 283  Bit Score: 67.36  E-value: 2.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLddpAEDNLYLVFDLLRKGPV---MEVpCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRD 275
Cdd:cd14149    58 EVAVLRKTRHVNILLFMGYM---TKDNLAIVTQWCEGSSLykhLHV-QETKFQMFQLIDIARQTAQGMDYLHAKNIIHRD 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLLGDDGHVKIADFG---VSNQFEGNDaQLSSTAGTPAFMAPEAIS-DSGQSFSGKAlDVWATGVTLYCFVYGKC 351
Cdd:cd14149   134 MKSNNIFLHEGLTVKIGDFGlatVKSRWSGSQ-QVEQPTGSILWMAPEVIRmQDNNPFSFQS-DVYSYGIVLYELMTGEL 211

                  ..
gi 1384865967 352 PF 353
Cdd:cd14149   212 PY 213
STKc_CDC2L6 cd07867
Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the ...
198-340 3.02e-12

Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L6 is also called CDK8-like and was previously referred to as CDK11. However, this is a confusing nomenclature as CDC2L6 is distinct from CDC2L1, which is represented by the two protein products from its gene, called CDK11(p110) and CDK11(p58), as well as the caspase-processed CDK11(p46). CDK11(p110), CDK11(p58), and CDK11(p46)do not belong to this subfamily. CDC2L6 is an associated protein of Mediator, a multiprotein complex that provides a platform to connect transcriptional and chromatin regulators and cofactors, in order to activate and mediate RNA polymerase II transcription. CDC2L6 is localized mainly in the nucleus amd exerts an opposing effect to CDK8 in VP16-dependent transcriptional activation by being a negative regulator. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270850 [Multi-domain]  Cd Length: 318  Bit Score: 67.40  E-value: 3.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEV-----------LDDPAEDNLYLVFDLLRKGPVMEVPCDkpFPEEQARLYLRDIILGLEYL 266
Cdd:cd07867    48 REIALLRELKHPNVIALQKVflshsdrkvwlLFDYAEHDLWHIIKFHRASKANKKPMQ--LPRSMVKSLLYQILDGIHYL 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 267 HCQKIVHRDIKPSNLLL----GDDGHVKIADFGVSNQFEG---NDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWAT 339
Cdd:cd07867   126 HANWVLHRDLKPANILVmgegPERGRVKIADMGFARLFNSplkPLADLDPVVVTFWYRAPELL--LGARHYTKAIDIWAI 203

                  .
gi 1384865967 340 G 340
Cdd:cd07867   204 G 204
STKc_A-Raf cd14150
Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) ...
199-353 3.16e-12

Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A-Raf cooperates with C-Raf in regulating ERK transient phosphorylation that is associated with cyclin D expression and cell cycle progression. Mice deficient in A-Raf are born alive but show neurological and intestinal defects. A-Raf demonstrates low kinase activity to MEK, compared with B- and C-Raf, and may also have alternative functions other than in the ERK signaling cascade. It regulates the M2 type pyruvate kinase, a key glycolytic enzyme. It also plays a role in endocytic membrane trafficking. A-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The A-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271052 [Multi-domain]  Cd Length: 265  Bit Score: 66.96  E-value: 3.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPaedNLYLVF------DLLRKGPVMEVPcdkpFPEEQARLYLRDIILGLEYLHCQKIV 272
Cdd:cd14150    46 EMQVLRKTRHVNILLFMGFMTRP---NFAIITqwcegsSLYRHLHVTETR----FDTMQLIDVARQTAQGMDYLHAKNII 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 273 HRDIKPSNLLLGDDGHVKIADFG---VSNQFEGNDaQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYG 349
Cdd:cd14150   119 HRDLKSNNIFLHEGLTVKIGDFGlatVKTRWSGSQ-QVEQPSGSILWMAPEVIRMQDTNPYSFQSDVYAYGVVLYELMSG 197

                  ....
gi 1384865967 350 KCPF 353
Cdd:cd14150   198 TLPY 201
STKc_B-Raf cd14151
Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) ...
257-353 3.20e-12

Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. B-Raf activates ERK with the strongest magnitude, compared with other Raf kinases. Mice embryos deficient in B-Raf die around midgestation due to vascular hemorrhage caused by apoptotic endothelial cells. Mutations in B-Raf have been implicated in initiating tumorigenesis and tumor progression, and are found in malignant cutaneous melanoma, papillary thyroid cancer, as well as in ovarian and colorectal carcinomas. Most oncogenic B-Raf mutations are located at the activation loop of the kinase and surrounding regions; the V600E mutation accounts for around 90% of oncogenic mutations. The V600E mutant constitutively activates MEK, resulting in sustained activation of ERK. B-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The B-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271053 [Multi-domain]  Cd Length: 274  Bit Score: 67.01  E-value: 3.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 257 RDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFG---VSNQFEGNDaQLSSTAGTPAFMAPEAISDSGQSFSGKA 333
Cdd:cd14151   111 RQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGlatVKSRWSGSH-QFEQLSGSILWMAPEVIRMQDKNPYSFQ 189
                          90       100
                  ....*....|....*....|
gi 1384865967 334 LDVWATGVTLYCFVYGKCPF 353
Cdd:cd14151   190 SDVYAFGIVLYELMTGQLPY 209
STKc_CDK8 cd07868
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs ...
198-340 3.33e-12

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK8 can act as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II (RNAP II)-dependent transcription. CDK8 phosphorylates cyclin H, a subunit of the general transcription factor TFIIH, which results in the inhibition of TFIIH-dependent phosphorylation of the C-terminal domain of RNAP II, facilitating the inhibition of transcription. It has also been shown to promote transcription by a mechanism that is likely to involve RNAP II phosphorylation. CDK8 also functions as a stimulus-specific positive coregulator of p53 transcriptional responses. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270851 [Multi-domain]  Cd Length: 333  Bit Score: 67.78  E-value: 3.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFD-----------LLRKGPVMEVPCDKPFPEEQARLYlrDIILGLEYL 266
Cdd:cd07868    63 REIALLRELKHPNVISLQKVFLSHADRKVWLLFDyaehdlwhiikFHRASKANKKPVQLPRGMVKSLLY--QILDGIHYL 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 267 HCQKIVHRDIKPSNLLL----GDDGHVKIADFGVSNQFEG---NDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWAT 339
Cdd:cd07868   141 HANWVLHRDLKPANILVmgegPERGRVKIADMGFARLFNSplkPLADLDPVVVTFWYRAPELL--LGARHYTKAIDIWAI 218

                  .
gi 1384865967 340 G 340
Cdd:cd07868   219 G 219
STKc_EIF2AK1_HRI cd14049
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
195-343 3.90e-12

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HRI (or EIF2AK1) contains an N-terminal regulatory heme-binding domain and a C-terminal catalytic kinase domain. It is suppressed under normal conditions by binding of the heme iron, and is activated during heme deficiency. It functions as a critical regulator that ensures balanced synthesis of globins and heme, in order to form stable hemoglobin during erythroid differentiation and maturation. HRI also protects cells and enhances survival under iron-deficient conditions. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The HRI subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270951 [Multi-domain]  Cd Length: 284  Bit Score: 66.76  E-value: 3.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 195 RVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDL----LR-------KGPVMEVPCDKPFPEEQARL---YLRDII 260
Cdd:cd14049    51 KVLREVKVLAGLQHPNIVGYHTAWMEHVQLMLYIQMQLcelsLWdwivernKRPCEEEFKSAPYTPVDVDVttkILQQLL 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 261 LGLEYLHCQKIVHRDIKPSNLLL-GDDGHVKIADFGVS--NQFEGNDAQL----------SSTAGTPAFMAPEAIsdSGQ 327
Cdd:cd14049   131 EGVTYIHSMGIVHRDLKPRNIFLhGSDIHVRIGDFGLAcpDILQDGNDSTtmsrlnglthTSGVGTCLYAAPEQL--EGS 208
                         170
                  ....*....|....*.
gi 1384865967 328 SFSGKAlDVWATGVTL 343
Cdd:cd14049   209 HYDFKS-DMYSIGVIL 223
pk1 PHA03390
serine/threonine-protein kinase 1; Provisional
230-408 4.19e-12

serine/threonine-protein kinase 1; Provisional


Pssm-ID: 223069 [Multi-domain]  Cd Length: 267  Bit Score: 66.42  E-value: 4.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 230 FDLLRKgpvmevpcDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGD-DGHVKIADFGVSnQFEGndaQLS 308
Cdd:PHA03390   97 FDLLKK--------EGKLSEAEVKKIIRQLVEALNDLHKHNIIHNDIKLENVLYDRaKDRIYLCDYGLC-KIIG---TPS 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 309 STAGTPAFMAPEAISDS--GQSFsgkalDVWATGVTLYCFVYGKCPFIDDY-----ILTLHRKIKNEaVVFPEepEVSED 381
Cdd:PHA03390  165 CYDGTLDYFSPEKIKGHnyDVSF-----DWWAVGVLTYELLTGKHPFKEDEdeeldLESLLKRQQKK-LPFIK--NVSKN 236
                         170       180
                  ....*....|....*....|....*...
gi 1384865967 382 LKDLILRMLDKNPETR-IGVSDIKLHPW 408
Cdd:PHA03390  237 ANDFVQSMLKYNINYRlTNYNEIIKHPF 264
PTKc_Ror cd05048
Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan ...
198-353 4.94e-12

Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Ror subfamily consists of Ror1, Ror2, and similar proteins. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. Ror kinases are expressed in many tissues during development. They play important roles in bone and heart formation. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Drosophila Ror is expressed only in the developing nervous system during neurite outgrowth and neuronal differentiation, suggesting a role for Drosophila Ror in neural development. More recently, mouse Ror1 and Ror2 have also been found to play an important role in regulating neurite growth in central neurons. Ror1 and Ror2 are believed to have some overlapping and redundant functions. The Ror subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270642 [Multi-domain]  Cd Length: 283  Bit Score: 66.63  E-value: 4.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVL--DDPaednLYLVFD----------LLRKGPVMEVPCDKPFPEEQARLYLRD------- 258
Cdd:cd05048    57 REAELMSDLQHPNIVCLLGVCtkEQP----QCMLFEymahgdlhefLVRHSPHSDVGVSSDDDGTASSLDQSDflhiaiq 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 259 IILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGND--AQLSSTAGTPAFMAPEAIsdsgqsFSGK---A 333
Cdd:cd05048   133 IAAGMEYLSSHHYVHRDLAARNCLVGDGLTVKISDFGLSRDIYSSDyyRVQSKSLLPVRWMPPEAI------LYGKfttE 206
                         170       180
                  ....*....|....*....|.
gi 1384865967 334 LDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05048   207 SDVWSFGVVLWeIFSYGLQPY 227
PHA03210 PHA03210
serine/threonine kinase US3; Provisional
199-343 5.92e-12

serine/threonine kinase US3; Provisional


Pssm-ID: 165476 [Multi-domain]  Cd Length: 501  Bit Score: 67.80  E-value: 5.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPaeDNLYLV-----FDL---LRKGPVMEVpcDKPFPEeQARLYLRDIILGLEYLHCQK 270
Cdd:PHA03210  213 EILALGRLNHENILKIEEILRSE--ANTYMItqkydFDLysfMYDEAFDWK--DRPLLK-QTRAIMKQLLCAVEYIHDKK 287
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEG-NDAQLSSTAGTPAFMAPEAISDSGQSfsgKALDVWATGVTL 343
Cdd:PHA03210  288 LIHRDIKLENIFLNCDGKIVLGDFGTAMPFEKeREAFDYGWVGTVATNSPEILAGDGYC---EITDIWSCGLIL 358
PKc_Dusty cd13975
Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze ...
258-350 6.55e-12

Catalytic domain of the Dual-specificity Protein Kinase, Dusty; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Dusty protein kinase is also called Receptor-interacting protein kinase 5 (RIPK5 or RIP5) or RIP-homologous kinase. It is widely distributed in the central nervous system, and may be involved in inducing both caspase-dependent and caspase-independent cell death. The Dusty subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270877 [Multi-domain]  Cd Length: 262  Bit Score: 65.97  E-value: 6.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 258 DIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGvsnqFEGNDAQLS-STAGTPAFMAPEAisdsgqsFSGK---A 333
Cdd:cd13975   110 DVVEGIRFLHSQGLVHRDIKLKNVLLDKKNRAKITDLG----FCKPEAMMSgSIVGTPIHMAPEL-------FSGKydnS 178
                          90
                  ....*....|....*..
gi 1384865967 334 LDVWATGVTLYCFVYGK 350
Cdd:cd13975   179 VDVYAFGILFWYLCAGH 195
PTKc_FGFR4 cd05099
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs ...
193-353 7.26e-12

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Unlike other FGFRs, there is only one splice form of FGFR4. It binds FGF1, FGF2, FGF6, FGF19, and FGF23. FGF19 is a selective ligand for FGFR4. Although disruption of FGFR4 in mice causes no obvious phenotype, in vivo inhibition of FGFR4 in cultured skeletal muscle cells resulted in an arrest of muscle progenitor differentiation. FGF6 and FGFR4 are uniquely expressed in myofibers and satellite cells. FGF6/FGFR4 signaling appears to play a key role in the regulation of muscle regeneration. A polymorphism in FGFR4 is found in head and neck squamous cell carcinoma. FGFR4 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133230 [Multi-domain]  Cd Length: 314  Bit Score: 66.53  E-value: 7.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLD-HVNVVKLIEVLDDpaEDNLYLVFDLLRKG-----------PVMEVPCDKP-FPEEQarLYLRDI 259
Cdd:cd05099    61 LADLISEMELMKLIGkHKNIINLLGVCTQ--EGPLYVIVEYAAKGnlreflrarrpPGPDYTFDITkVPEEQ--LSFKDL 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 260 I-------LGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG-TPA-FMAPEAISD---SGQ 327
Cdd:cd05099   137 VscayqvaRGMEYLESRRCIHRDLAARNVLVTEDNVMKIADFGLARGVHDIDYYKKTSNGrLPVkWMAPEALFDrvyTHQ 216
                         170       180
                  ....*....|....*....|....*..
gi 1384865967 328 SfsgkalDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05099   217 S------DVWSFGILMWeIFTLGGSPY 237
PTKc_VEGFR1 cd14207
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
245-397 7.94e-12

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR1 (or Flt1) binds VEGFA, VEGFB, and placenta growth factor (PLGF). It regulates monocyte and macrophage migration, vascular permeability, haematopoiesis, and the recruitment of haematopietic progenitor cells from the bone marrow. VEGFR1 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271109 [Multi-domain]  Cd Length: 340  Bit Score: 66.56  E-value: 7.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 245 KPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGN-DAQLSSTAGTP-AFMAPEAI 322
Cdd:cd14207   175 RPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNpDYVRKGDARLPlKWMAPESI 254
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 323 SDsgQSFSGKAlDVWATGVTLY-CFVYGKCPF----ID-DYILTLHRKIKNEAvvfPEepEVSEDLKDLILRMLDKNPET 396
Cdd:cd14207   255 FD--KIYSTKS-DVWSYGVLLWeIFSLGASPYpgvqIDeDFCSKLKEGIRMRA---PE--FATSEIYQIMLDCWQGDPNE 326

                  .
gi 1384865967 397 R 397
Cdd:cd14207   327 R 327
PKc_like cd13968
Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large ...
193-295 9.69e-12

Catalytic domain of the Protein Kinase superfamily; The PK superfamily contains the large family of typical PKs that includes serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins, as well as pseudokinases that lack crucial residues for catalytic activity and/or ATP binding. It also includes phosphoinositide 3-kinases (PI3Ks), aminoglycoside 3'-phosphotransferases (APHs), choline kinase (ChoK), Actin-Fragmin Kinase (AFK), and the atypical RIO and Abc1p-like protein kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to their target substrates; these include serine/threonine/tyrosine residues in proteins for typical or atypical PKs, the 3-hydroxyl of the inositol ring of D-myo-phosphatidylinositol (PtdIns) or its derivatives for PI3Ks, the 4-hydroxyl of PtdIns for PI4Ks, and other small molecule substrates for APH/ChoK and similar proteins such as aminoglycosides, macrolides, choline, ethanolamine, and homoserine.


Pssm-ID: 270870 [Multi-domain]  Cd Length: 136  Bit Score: 62.46  E-value: 9.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLD--HVNVVKLI--EVLDDPaednLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHC 268
Cdd:cd13968    34 GEDLESEMDILRRLKglELNIPKVLvtEDVDGP----NILLMELVKGGTLIAYTQEEELDEKDVESIMYQLAECMRLLHS 109
                          90       100
                  ....*....|....*....|....*..
gi 1384865967 269 QKIVHRDIKPSNLLLGDDGHVKIADFG 295
Cdd:cd13968   110 FHLIHRDLNNDNILLSEDGNVKLIDFG 136
STKc_SRPK cd14136
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze ...
256-408 9.89e-12

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. They play important roles in mediating pre-mRNA processing and mRNA maturation, as well as other cellular functions such as chromatin reorganization, cell cycle and p53 regulation, and metabolic signaling. Vertebrates contain three distinct SRPKs, called SRPK1-3. The SRPK homolog in budding yeast, Sky1p, recognizes and phosphorylates its substrate Npl3p, which lacks a classic RS domain but contains a single RS dipeptide at the C-terminus of its RGG domain. Npl3p is a shuttling heterogeneous nuclear ribonucleoprotein (hnRNP) that exports a distinct class of mRNA from the nucleus to the cytoplasm. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271038 [Multi-domain]  Cd Length: 320  Bit Score: 66.06  E-value: 9.89e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 256 LRDIILGLEYLH--CqKIVHRDIKPSNLLLG-DDGHVKIADFG----VSNQFEgNDAQlsstagTPAFMAPEAISDSGQS 328
Cdd:cd14136   125 ARQVLQGLDYLHtkC-GIIHTDIKPENVLLCiSKIEVKIADLGnacwTDKHFT-EDIQ------TRQYRSPEVILGAGYG 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 329 FSGkalDVWATGVTLYCFVYGKCPF----------IDDYI-------------LTL--------------HRKIKN---- 367
Cdd:cd14136   197 TPA---DIWSTACMAFELATGDYLFdphsgedysrDEDHLaliiellgriprsIILsgkysreffnrkgeLRHISKlkpw 273
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1384865967 368 -------EAVVFPEepEVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14136   274 pledvlvEKYKWSK--EEAKEFASFLLPMLEYDPEKRATAAQCLQHPW 319
PTKc_DDR1 cd05096
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; PTKs catalyze ...
198-411 2.21e-11

Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR1 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR1 results in a slow but sustained receptor activation. DDR1 binds to all collagens tested to date (types I-IV). It is widely expressed in many tissues. It is abundant in the brain and is also found in keratinocytes, colonic mucosa epithelium, lung epithelium, thyroid follicles, and the islets of Langerhans. During embryonic development, it is found in the developing neuroectoderm. DDR1 is a key regulator of cell morphogenesis, differentiation and proliferation. It is important in the development of the mammary gland, the vasculator and the kidney. DDR1 is also found in human leukocytes, where it facilitates cell adhesion, migration, maturation, and cytokine production. The DDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133227 [Multi-domain]  Cd Length: 304  Bit Score: 64.96  E-value: 2.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVL--DDP----------AEDNLYLVFDLLRKGPVMEVPCDK-----PFPEEQARLYL-RDI 259
Cdd:cd05096    68 KEVKILSRLKDPNIIRLLGVCvdEDPlcmiteymenGDLNQFLSSHHLDDKEENGNDAVPpahclPAISYSSLLHVaLQI 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 260 ILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS-NQFEGNDAQLSSTAGTPA-FMAPEAIsdsgqsFSGK---AL 334
Cdd:cd05096   148 ASGMKYLSSLNFVHRDLATRNCLVGENLTIKIADFGMSrNLYAGDYYRIQGRAVLPIrWMAWECI------LMGKfttAS 221
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 335 DVWATGVTLY--CFVYGKCPFIDdyiLTLHRKIKNEAVVFPEE---------PEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd05096   222 DVWAFGVTLWeiLMLCKEQPYGE---LTDEQVIENAGEFFRDQgrqvylfrpPPCPQGLYELMLQCWSRDCRERPSFSDI 298

                  ....*...
gi 1384865967 404 klHPWVTK 411
Cdd:cd05096   299 --HAFLTE 304
PTKc_Btk_Bmx cd05113
Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow ...
197-353 2.39e-11

Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Btk and Bmx (also named Etk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Btk contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor, leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans. Bmx is primarily expressed in bone marrow and the arterial endothelium, and plays an important role in ischemia-induced angiogenesis. It facilitates arterial growth, capillary formation, vessel maturation, and bone marrow-derived endothelial progenitor cell mobilization. The Btk/Bmx subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173657 [Multi-domain]  Cd Length: 256  Bit Score: 64.13  E-value: 2.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 197 YQEIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVMEV--PCDKPFPEEQARLYLRDIILGLEYLHCQKIVHR 274
Cdd:cd05113    47 IEEAKVMMNLSHEKLVQLYGVCT--KQRPIFIITEYMANGCLLNYlrEMRKRFQTQQLLEMCKDVCEAMEYLESKQFLHR 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 275 DIKPSNLLLGDDGHVKIADFGVSNQFEgnDAQLSSTAGTP---AFMAPEAISDSgqSFSGKAlDVWATGVTLY-CFVYGK 350
Cdd:cd05113   125 DLAARNCLVNDQGVVKVSDFGLSRYVL--DDEYTSSVGSKfpvRWSPPEVLMYS--KFSSKS-DVWAFGVLMWeVYSLGK 199

                  ...
gi 1384865967 351 CPF 353
Cdd:cd05113   200 MPY 202
PTKc_FGFR3 cd05100
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs ...
234-353 2.42e-11

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Many FGFR3 splice variants have been reported with the IIIb and IIIc isoforms being the predominant forms. FGFR3 IIIc is the isoform expressed in chondrocytes, the cells affected in dwarfism, while IIIb is expressed in epithelial cells. FGFR3 ligands include FGF1, FGF2, FGF4, FGF8, FGF9, and FGF23. It is a negative regulator of long bone growth. In the cochlear duct and in the lens, FGFR3 is involved in differentiation while it appears to have a role in cell proliferation in epithelial cells. Germline mutations in FGFR3 are associated with skeletal disorders including several forms of dwarfism. Some missense mutations are associated with multiple myeloma and carcinomas of the bladder and cervix. Overexpression of FGFR3 is found in thyroid carcinoma. FGFR3 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173652 [Multi-domain]  Cd Length: 334  Bit Score: 65.04  E-value: 2.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 234 RKGPVMEVPCDK-PFPEEQarLYLRDII-------LGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDA 305
Cdd:cd05100   112 RRPPGMDYSFDTcKLPEEQ--LTFKDLVscayqvaRGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDY 189
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 306 QLSSTAGT-PA-FMAPEAISDSGQSFSGkalDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05100   190 YKKTTNGRlPVkWMAPEALFDRVYTHQS---DVWSFGVLLWeIFTLGGSPY 237
PTKc_Syk cd05116
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the ...
198-405 2.90e-11

Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Syk is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Syk was first cloned from the spleen, and its function in hematopoietic cells is well-established. It is involved in the signaling downstream of activated receptors (including B-cell and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. More recently, Syk expression has been detected in other cell types (including epithelial cells, vascular endothelial cells, neurons, hepatocytes, and melanocytes), suggesting a variety of biological functions in non-immune cells. Syk plays a critical role in maintaining vascular integrity and in wound healing during embryogenesis. It also regulates Vav3, which is important in osteoclast function including bone development. In breast epithelial cells, where Syk acts as a negative regulator for EGFR signaling, loss of Syk expression is associated with abnormal proliferation during cancer development suggesting a potential role as a tumor suppressor. In mice, Syk has been shown to inhibit malignant transformation of mammary epithelial cells induced with murine mammary tumor virus (MMTV). The Syk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133247 [Multi-domain]  Cd Length: 257  Bit Score: 63.83  E-value: 2.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDdpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd05116    45 REANVMQQLDNPYIVRMIGICE---AESWMLVMEMAELGPLNKfLQKNRHVTEKNITELVHQVSMGMKYLEESNFVHRDL 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQF--EGNDAQLSSTAGTPA-FMAPEAIsdSGQSFSGKAlDVWATGVTLY-CFVYGKCP 352
Cdd:cd05116   122 AARNVLLVTQHYAKISDFGLSKALraDENYYKAQTHGKWPVkWYAPECM--NYYKFSSKS-DVWSFGVLMWeAFSYGQKP 198
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 353 FiddyiltlhRKIK-NEAVVFPEE-------PEVSEDLKDLILRMLDKNPETRIGVSDIKL 405
Cdd:cd05116   199 Y---------KGMKgNEVTQMIEKgermecpAGCPPEMYDLMKLCWTYDVDERPGFAAVEL 250
PTKc_Musk cd05050
Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the ...
198-353 3.69e-11

Catalytic domain of the Protein Tyrosine Kinase, Muscle-specific kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Musk is a receptor PTK (RTK) containing an extracellular region with four immunoglobulin-like domains and a cysteine-rich cluster, a transmembrane segment, and an intracellular catalytic domain. Musk is expressed and concentrated in the postsynaptic membrane in skeletal muscle. It is essential for the establishment of the neuromuscular junction (NMJ), a peripheral synapse that conveys signals from motor neurons to muscle cells. Agrin, a large proteoglycan released from motor neurons, stimulates Musk autophosphorylation and activation, leading to the clustering of acetylcholine receptors (AChRs). To date, there is no evidence to suggest that agrin binds directly to Musk. Mutations in AChR, Musk and other partners are responsible for diseases of the NMJ, such as the autoimmune syndrome myasthenia gravis. The Musk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133181 [Multi-domain]  Cd Length: 288  Bit Score: 64.08  E-value: 3.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEV--LDDPaednLYLVFDLLRKGPVME--------------------VPCDKPFPE--EQAR 253
Cdd:cd05050    57 REAALMAEFDHPNIVKLLGVcaVGKP----MCLLFEYMAYGDLNEflrhrspraqcslshstssaRKCGLNPLPlsCTEQ 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 254 LYL-RDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGND-AQLSSTAGTPA-FMAPEAISDSgqSFS 330
Cdd:cd05050   133 LCIaKQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADyYKASENDAIPIrWMPPESIFYN--RYT 210
                         170       180
                  ....*....|....*....|....
gi 1384865967 331 GKAlDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05050   211 TES-DVWAYGVVLWeIFSYGMQPY 233
PTKc_DDR cd05051
Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors; PTKs catalyze ...
198-397 3.80e-11

Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The DDR subfamily consists of homologs of mammalian DDR1, DDR2, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270644 [Multi-domain]  Cd Length: 297  Bit Score: 63.90  E-value: 3.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVL--DDPaednLYLVFDLLRKG------------PVMEVPCDKPFPEEQARLYL-RDIILG 262
Cdd:cd05051    68 KEVKIMSQLKDPNIVRLLGVCtrDEP----LCMIVEYMENGdlnqflqkheaeTQGASATNSKTLSYGTLLYMaTQIASG 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS-NQFEGNDAQLSSTAGTPA-FMAPEAIsdSGQSFSGKAlDVWATG 340
Cdd:cd05051   144 MKYLESLNFVHRDLATRNCLVGPNYTIKIADFGMSrNLYSGDYYRIEGRAVLPIrWMAWESI--LLGKFTTKS-DVWAFG 220
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 341 VTLYcfvygkcpfiddYILTLHRK-----------IKN---------EAVVFPEEPEVSEDLKDLILRMLDKNPETR 397
Cdd:cd05051   221 VTLW------------EILTLCKEqpyehltdeqvIENageffrddgMEVYLSRPPNCPKEIYELMLECWRRDEEDR 285
PTKc_Ror1 cd05090
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
198-353 3.91e-11

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror kinases are expressed in many tissues during development. Avian Ror1 was found to be involved in late limb development. Studies in mice reveal that Ror1 is important in the regulation of neurite growth in central neurons, as well as in respiratory development. Loss of Ror1 also enhances the heart and skeletal abnormalities found in Ror2-deficient mice. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270672 [Multi-domain]  Cd Length: 283  Bit Score: 63.88  E-value: 3.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKG----------PVMEVPCD-------KPFPEEQARLYLR-DI 259
Cdd:cd05090    56 QEASLMTELHHPNIVCLLGVVTQ--EQPVCMLFEFMNQGdlheflimrsPHSDVGCSsdedgtvKSSLDHGDFLHIAiQI 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 260 ILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGND-AQLSSTAGTPA-FMAPEAISDSgqSFSGKAlDVW 337
Cdd:cd05090   134 AAGMEYLSSHFFVHKDLAARNILVGEQLHVKISDLGLSREIYSSDyYRVQNKSLLPIrWMPPEAIMYG--KFSSDS-DIW 210
                         170
                  ....*....|....*..
gi 1384865967 338 ATGVTLY-CFVYGKCPF 353
Cdd:cd05090   211 SFGVVLWeIFSFGLQPY 227
PKc_MEK2 cd06649
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
245-352 4.27e-11

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK2 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132980 [Multi-domain]  Cd Length: 331  Bit Score: 64.30  E-value: 4.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 245 KPFPEEQARLYLRDIILGLEYLHCQ-KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEgnDAQLSSTAGTPAFMAPEAIs 323
Cdd:cd06649    98 KRIPEEILGKVSIAVLRGLAYLREKhQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLI--DSMANSFVGTRSYMSPERL- 174
                          90       100
                  ....*....|....*....|....*....
gi 1384865967 324 dSGQSFSGKAlDVWATGVTLYCFVYGKCP 352
Cdd:cd06649   175 -QGTHYSVQS-DIWSMGLSLVELAIGRYP 201
PTKc_DDR_like cd05097
Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the ...
126-344 6.41e-11

Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR-like proteins are members of the DDR subfamily, which are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133228 [Multi-domain]  Cd Length: 295  Bit Score: 63.46  E-value: 6.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 126 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrPPPRGSQATQGGPAKQLLP------LERVYQE 199
Cdd:cd05097     5 QQLRLKEKLGEGQFGEVHLCEAEGLAEFLGE-----------------GAPEFDGQPVLVAVKMLRAdvtktaRNDFLKE 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 200 IAILKKLDHVNVVKLIEVL--DDPaednLYLVFDLLRKGPVMEVPCDK------------PFPEEQARLYLR-DIILGLE 264
Cdd:cd05097    68 IKIMSRLKNPNIIRLLGVCvsDDP----LCMITEYMENGDLNQFLSQReiestfthanniPSVSIANLLYMAvQIASGMK 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 265 YLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS-NQFEGNDAQLSSTAGTPA-FMAPEAIsdsgqsFSGK---ALDVWAT 339
Cdd:cd05097   144 YLASLNFVHRDLATRNCLVGNHYTIKIADFGMSrNLYSGDYYRIQGRAVLPIrWMAWESI------LLGKfttASDVWAF 217

                  ....*
gi 1384865967 340 GVTLY 344
Cdd:cd05097   218 GVTLW 222
PTK_CCK4 cd05046
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also ...
198-403 6.87e-11

Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also called protein tyrosine kinase 7 (PTK7), is an orphan receptor PTK (RTK) containing an extracellular region with seven immunoglobulin domains, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Studies in mice reveal that CCK4 is essential for neural development. Mouse embryos containing a truncated CCK4 die perinatally and display craniorachischisis, a severe form of neural tube defect. The mechanism of action of the CCK4 pseudokinase is still unknown. Other pseudokinases such as HER3 rely on the activity of partner RTKs. The CCK4 subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133178 [Multi-domain]  Cd Length: 275  Bit Score: 62.87  E-value: 6.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME--------VPCDKPFP-EEQARLYL-RDIILGLEYLH 267
Cdd:cd05046    57 RELDMFRKLSHKNVVRLLGLCRE--AEPHYMILEYTDLGDLKQflratkskDEKLKPPPlSTKQKVALcTQIALGMDHLS 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 268 CQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPA-FMAPEAISDSgqSFSGKAlDVWATGVTLY-C 345
Cdd:cd05046   135 NARFVHRDLAARNCLVSSQREVKVSLLSLSKDVYNSEYYKLRNALIPLrWLAPEAVQED--DFSTKS-DVWSFGVLMWeV 211
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 346 FVYGKCPF---IDDYILTlhrKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd05046   212 FTQGELPFyglSDEEVLN---RLQAGKLELPVPEGCPSRLYKLMTRCWAVNPKDRPSFSEL 269
PTKc_FGFR1 cd05098
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs ...
193-353 1.05e-10

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Alternative splicing of FGFR1 transcripts produces a variety of isoforms, which are differentially expressed in cells. FGFR1 binds the ligands, FGF1 and FGF2, with high affinity and has also been reported to bind FGF4, FGF6, and FGF9. FGFR1 signaling is critical in the control of cell migration during embryo development. It promotes cell proliferation in fibroblasts. Nuclear FGFR1 plays a role in the regulation of transcription. Mutations, insertions or deletions of FGFR1 have been identified in patients with Kallman's syndrome (KS), an inherited disorder characterized by hypogonadotropic hypogonadism and loss of olfaction. Aberrant FGFR1 expression has been found in some human cancers including 8P11 myeloproliferative syndrome (EMS), breast cancer, and pancreatic adenocarcinoma. FGFR1 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270678 [Multi-domain]  Cd Length: 302  Bit Score: 62.72  E-value: 1.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKL-DHVNVVKLIEVL--DDPaednLYLVFDLLRKG-----------PVMEVpCDKP--FPEEQarLYL 256
Cdd:cd05098    62 LSDLISEMEMMKMIgKHKNIINLLGACtqDGP----LYVIVEYASKGnlreylqarrpPGMEY-CYNPshNPEEQ--LSS 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 257 RDII-------LGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGT-PA-FMAPEAISD--- 324
Cdd:cd05098   135 KDLVscayqvaRGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRlPVkWMAPEALFDriy 214
                         170       180       190
                  ....*....|....*....|....*....|
gi 1384865967 325 SGQSfsgkalDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05098   215 THQS------DVWSFGVLLWeIFTLGGSPY 238
STKc_CK1 cd14016
Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the ...
127-300 1.20e-10

Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK1 phosphorylates a variety of substrates including enzymes, transcription and splice factors, cytoskeletal proteins, viral oncogenes, receptors, and membrane-associated proteins. There are mutliple isoforms of CK1 and in mammals, seven isoforms (alpha, beta, gamma1-3, delta, and epsilon) have been characterized. These isoforms differ mainly in the length and structure of their C-terminal non-catalytic region. Some isoforms have several splice variants such as the long (L) and short (S) variants of CK1alpha. CK1 proteins are involved in the regulation of many cellular processes including membrane transport processes, circadian rhythm, cell division, apoptosis, and the development of cancer and neurodegenerative diseases. The CK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270918 [Multi-domain]  Cd Length: 266  Bit Score: 62.09  E-value: 1.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprRPPPRGSQATQggpakqllpLERvyqEIAILKKL 206
Cdd:cd14016     1 RYKLVKKIGSGSFGEVYLGIDLKTGEEVAI----------------KIEKKDSKHPQ---------LEY---EAKVYKLL 52
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 -DHVNVVKLIEVLDDpaEDNLYLVFDLLrkGPVME---VPCDKPFPEEQArLYLRD-IILGLEYLHCQKIVHRDIKPSNL 281
Cdd:cd14016    53 qGGPGIPRLYWFGQE--GDYNVMVMDLL--GPSLEdlfNKCGRKFSLKTV-LMLADqMISRLEYLHSKGYIHRDIKPENF 127
                         170       180
                  ....*....|....*....|..
gi 1384865967 282 LLGDDGHVK---IADFGVSNQF 300
Cdd:cd14016   128 LMGLGKNSNkvyLIDFGLAKKY 149
PTKc_TrkB cd05093
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze ...
130-403 1.27e-10

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkB is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkB to its ligands, brain-derived neurotrophic factor (BDNF) or neurotrophin 4 (NT4), results in receptor oligomerization and activation of the catalytic domain. TrkB is broadly expressed in the nervous system and in some non-neural tissues. It plays important roles in cell proliferation, differentiation, and survival. BDNF/Trk signaling plays a key role in regulating activity-dependent synaptic plasticity. TrkB also contributes to protection against gp120-induced neuronal cell death. TrkB overexpression is associated with poor prognosis in neuroblastoma (NB) and other human cancers. It acts as a suppressor of anoikis (detachment-induced apoptosis) and contributes to tumor metastasis. The TrkB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270675 [Multi-domain]  Cd Length: 288  Bit Score: 62.37  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 130 LQSEIGKGAYGVVRLA--YNESEDRHYAMKVLSKKkllkqygfprrppprgSQATQGGPAKqllplerVYQEIAILKKLD 207
Cdd:cd05093     9 LKRELGEGAFGKVFLAecYNLCPEQDKILVAVKTL----------------KDASDNARKD-------FHREAELLTNLQ 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 208 HVNVVKLIEVLDDpaEDNLYLVFDLLRKG------------PVMEVPCDKPFPEEQARLY--LRDIILGLEYLHCQKIVH 273
Cdd:cd05093    66 HEHIVKFYGVCVE--GDPLIMVFEYMKHGdlnkflrahgpdAVLMAEGNRPAELTQSQMLhiAQQIAAGMVYLASQHFVH 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLGDDGHVKIADFGVSNQFEGND-AQLSSTAGTPA-FMAPEAIsdSGQSFSGKAlDVWATGVTLY-CFVYGK 350
Cdd:cd05093   144 RDLATRNCLVGENLLVKIGDFGMSRDVYSTDyYRVGGHTMLPIrWMPPESI--MYRKFTTES-DVWSLGVVLWeIFTYGK 220
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 351 CPFiddYILTLHRKIK--NEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd05093   221 QPW---YQLSNNEVIEciTQGRVLQRPRTCPKEVYDLMLGCWQREPHMRLNIKEI 272
PTKc_DDR2 cd05095
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze ...
198-344 1.56e-10

Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR2 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR2 results in a slow but sustained receptor activation. DDR2 binds mostly to fibrillar collagens as well as collagen X. DDR2 is widely expressed in many tissues with the highest levels found in skeletal muscle, skin, kidney and lung. It is important in cell proliferation and development. Mice, with a deletion of DDR2, suffer from dwarfism and delayed healing of epidermal wounds. DDR2 also contributes to collagen (type I) regulation by inhibiting fibrillogenesis and altering the morphology of collagen fibers. It is also expressed in immature dendritic cells (DCs), where it plays a role in DC activation and function. The DDR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270677 [Multi-domain]  Cd Length: 297  Bit Score: 62.32  E-value: 1.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKG-------------PVMEVPCDKPFPEEQARLYLRDIILGLE 264
Cdd:cd05095    68 KEIKIMSRLKDPNIIRLLAVC--ITDDPLCMITEYMENGdlnqflsrqqpegQLALPSNALTVSYSDLRFMAAQIASGMK 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 265 YLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS-NQFEGNDAQLSSTAGTPA-FMAPEAIsdsgqsFSGK---ALDVWAT 339
Cdd:cd05095   146 YLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSrNLYSGDYYRIQGRAVLPIrWMSWESI------LLGKfttASDVWAF 219

                  ....*
gi 1384865967 340 GVTLY 344
Cdd:cd05095   220 GVTLW 224
PTKc_Yes cd05069
Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the ...
194-353 1.69e-10

Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Yes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270654 [Multi-domain]  Cd Length: 279  Bit Score: 62.01  E-value: 1.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLddpAEDNLYLVFDLLRKGPVMEvpcdkpFPEEQARLYLR---------DIILGLE 264
Cdd:cd05069    52 EAFLQEAQIMKKLRHDKLVPLYAVV---SEEPIYIVTEFMGKGSLLD------FLKEGDGKYLKlpqlvdmaaQIADGMA 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 265 YLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAISDSgqSFSGKAlDVWATGVTL 343
Cdd:cd05069   123 YIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPiKWTAPEAALYG--RFTIKS-DVWSFGILL 199
                         170
                  ....*....|.
gi 1384865967 344 YCFVY-GKCPF 353
Cdd:cd05069   200 TELVTkGRVPY 210
PTKc_FGFR2 cd05101
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs ...
234-353 1.70e-10

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. There are many splice variants of FGFR2 which show differential expression and binding to FGF ligands. Disruption of either FGFR2 or FGFR2b is lethal in mice, due to defects in the placenta or severe impairment of tissue development including lung, limb, and thyroid, respectively. Disruption of FGFR2c in mice results in defective bone and skull development. Genetic alterations of FGFR2 are associated with many human skeletal disorders including Apert syndrome, Crouzon syndrome, Jackson-Weiss syndrome, and Pfeiffer syndrome. FGFR2 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270679 [Multi-domain]  Cd Length: 313  Bit Score: 62.34  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 234 RKGPVMEVPCD-KPFPEEQarLYLRDII-------LGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDA 305
Cdd:cd05101   124 RRPPGMEYSYDiNRVPEEQ--MTFKDLVsctyqlaRGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDY 201
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 306 QLSSTAGT-PA-FMAPEAISDSGQSFSGkalDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05101   202 YKKTTNGRlPVkWMAPEALFDRVYTHQS---DVWSFGVLMWeIFTLGGSPY 249
STKc_WNK1 cd14030
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze ...
194-406 2.36e-10

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK1 is widely expressed and is most abundant in the testis. In hyperosmotic or hypotonic low-chloride stress conditions, WNK1 is activated and it phosphorylates its substrates including SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. Mutations in WNK1 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK1 negates WNK4-mediated inhibition of the sodium-chloride cotransporter NCC and activates the epithelial sodium channel ENaC by activating SGK1. WNK1 also decreases the surface expression of renal outer medullary potassium channel (ROMK) by stimulating their endocytosis. Hypertension and hyperkalemia in PHAII patients with WNK1 mutations may be due partly to increased activity of NCC and ENaC, and impaired renal potassium secretion by ROMK, respectively. In addition, WNK1 interacts with MEKK2/3 and acts as an activator of extracellular signal-regulated kinase (ERK) 5. It also negatively regulates TGFbeta signaling. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270932 [Multi-domain]  Cd Length: 289  Bit Score: 61.60  E-value: 2.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEDN--LYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDIILGLEYLHCQK 270
Cdd:cd14030    69 QRFKEEAGMLKGLQHPNIVRFYDSWESTVKGKkcIVLVTELMTSGTLKTyLKRFKVMKIKVLRSWCRQILKGLQFLHTRT 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 --IVHRDIKPSNLLL-GDDGHVKIADFGVSNQFEGNDAQlsSTAGTPAFMAPEAISDSgqsfSGKALDVWATGVTLYCFV 347
Cdd:cd14030   149 ppIIHRDLKCDNIFItGPTGSVKIGDLGLATLKRASFAK--SVIGTPEFMAPEMYEEK----YDESVDVYAFGMCMLEMA 222
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 348 YGKCPFID-DYILTLHRKIKN-------EAVVFPEepevsedLKDLILRMLDKNPETRIGVSDIKLH 406
Cdd:cd14030   223 TSEYPYSEcQNAAQIYRRVTSgvkpasfDKVAIPE-------VKEIIEGCIRQNKDERYAIKDLLNH 282
PTKc_VEGFR2 cd05103
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; ...
243-353 3.44e-10

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR2 (or Flk1) binds the ligands VEGFA, VEGFC, VEGFD and VEGFE. VEGFR2 signaling is implicated in all aspects of normal and pathological vascular endothelial cell biology. It induces a variety of cellular effects including migration, survival, and proliferation. It is critical in regulating embryonic vascular development and angiogenesis. VEGFR2 is the major signal transducer in pathological angiogenesis including cancer and diabetic retinopathy, and is a target for inhibition in cancer therapy. The carboxyl terminus of VEGFR2 plays an important role in its autophosphorylation and activation. VEGFR2 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270681 [Multi-domain]  Cd Length: 343  Bit Score: 61.54  E-value: 3.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 243 CDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ-FEGNDAQLSSTAGTP-AFMAPE 320
Cdd:cd05103   172 YKDFLTLEDLICYSFQVAKGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDiYKDPDYVRKGDARLPlKWMAPE 251
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1384865967 321 AISD---SGQSfsgkalDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05103   252 TIFDrvyTIQS------DVWSFGVLLWeIFSLGASPY 282
PTKc_VEGFR cd05054
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
262-353 3.55e-10

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The VEGFR subfamily consists of VEGFR1 (Flt1), VEGFR2 (Flk1), VEGFR3 (Flt4), and similar proteins. VEGFR subfamily members are receptor PTKss (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. There are five VEGF ligands in mammals, which bind, in an overlapping pattern to the three VEGFRs, which can form homo or heterodimers. VEGFRs regulate the cardiovascular system. They are critical for vascular development during embryogenesis and blood vessel formation in adults. They induce cellular functions common to other growth factor receptors such as cell migration, survival, and proliferation. The VEGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270647 [Multi-domain]  Cd Length: 298  Bit Score: 60.97  E-value: 3.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ-FEGNDAQLSSTAGTP-AFMAPEAISDsgQSFSGKAlDVWAT 339
Cdd:cd05054   150 GMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDiYKDPDYVRKGDARLPlKWMAPESIFD--KVYTTQS-DVWSF 226
                          90
                  ....*....|....*
gi 1384865967 340 GVTLY-CFVYGKCPF 353
Cdd:cd05054   227 GVLLWeIFSLGASPY 241
PTKc_Fyn cd05070
Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the ...
194-397 4.04e-10

Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fyn and Yrk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's and Parkinson's diseases. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Fyn/Yrk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase.


Pssm-ID: 270655 [Multi-domain]  Cd Length: 274  Bit Score: 60.47  E-value: 4.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLddpAEDNLYLVFDLLRKGPVMEVPCDKpfpeEQARLYLRDII-------LGLEYL 266
Cdd:cd05070    49 ESFLEEAQIMKKLKHDKLVQLYAVV---SEEPIYIVTEYMSKGSLLDFLKDG----EGRALKLPNLVdmaaqvaAGMAYI 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 267 HCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP-AFMAPEAISDSgqSFSGKAlDVWATGVTLYC 345
Cdd:cd05070   122 ERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPiKWTAPEAALYG--RFTIKS-DVWSFGILLTE 198
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 346 FVY-GKCPFID-DYILTLHRKIKNEAVVFPEEPEVSedLKDLILRMLDKNPETR 397
Cdd:cd05070   199 LVTkGRVPYPGmNNREVLEQVERGYRMPCPQDCPIS--LHELMIHCWKKDPEER 250
STKc_Unc-89_rpt2 cd14112
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated ...
194-409 4.26e-10

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271014 [Multi-domain]  Cd Length: 259  Bit Score: 60.24  E-value: 4.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVH 273
Cdd:cd14112    45 SEAVREFESLRTLQHENVQRLIAAFKP--SNFAYLVMEKLQEDVFTRFSSNDYYSEEQVATTVRQILDALHYLHFKGIAH 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 274 RDIKPSNLLLGD--DGHVKIADFGVSNQFegNDAQLSSTAGTPAFMAPEAISDSGQSFSGKalDVWATGVTLYCFVYGKC 351
Cdd:cd14112   123 LDVQPDNIMFQSvrSWQVKLVDFGRAQKV--SKLGKVPVDGDTDWASPEFHNPETPITVQS--DIWGLGVLTFCLLSGFH 198
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 352 PFIDDYILTLHRK--IKNEAVVFPEEP-EVSEDLKDLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14112   199 PFTSEYDDEEETKenVIFVKCRPNLIFvEATQEALRFATWALKKSPTRRMRTDEALEHRWL 259
PTKc_Tie cd05047
Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
199-365 5.27e-10

Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie proteins, consisting of Tie1 and Tie2, are receptor PTKs (RTKs) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2, while no specific ligand has been identified for Tie1. The binding of Ang-1 to Tie2 leads to receptor autophosphorylation and activation, promoting cell migration and survival. In contrast, Ang-2 binding to Tie2 does not result in the same response, suggesting that Ang-2 may function as an antagonist. In vivo studies of Tie1 show that it is critical in vascular development. The Tie subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270641 [Multi-domain]  Cd Length: 270  Bit Score: 60.05  E-value: 5.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKL-DHVNVVKLIEVLDDpaEDNLYL---------VFDLLRKGPVMEVpcDKPFPEE----------QARLYLRD 258
Cdd:cd05047    45 ELEVLCKLgHHPNIINLLGACEH--RGYLYLaieyaphgnLLDFLRKSRVLET--DPAFAIAnstastlssqQLLHFAAD 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 259 IILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSnqfEGNDAQLSSTAGT-PA-FMAPEAISDSgqSFSGKAlDV 336
Cdd:cd05047   121 VARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLS---RGQEVYVKKTMGRlPVrWMAIESLNYS--VYTTNS-DV 194
                         170       180       190
                  ....*....|....*....|....*....|
gi 1384865967 337 WATGVTLYCFV-YGKCPFIDDYILTLHRKI 365
Cdd:cd05047   195 WSYGVLLWEIVsLGGTPYCGMTCAELYEKL 224
PK_STRAD cd08216
Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows ...
193-294 5.49e-10

Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. There are two forms of STRAD, alpha and beta, that complex with LKB1 and MO25. The structure of STRAD-alpha is available and shows that this protein binds ATP, has an ordered activation loop, and adopts a closed conformation typical of fully active protein kinases. It does not possess activity due to nonconservative substitutions of essential catalytic residues. ATP binding enhances the affinity of STRAD for MO25. The conformation of STRAD-alpha stabilized through ATP and MO25 may be needed to activate LKB1. The STRAD subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270856 [Multi-domain]  Cd Length: 315  Bit Score: 60.77  E-value: 5.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPAEdnLYLVFDLLRKGP---VMEVPCDKPFPEEQARLYLRDIILGLEYLHCQ 269
Cdd:cd08216    43 LKFLQQEILTSRQLQHPNILPYVTSFVVDND--LYVVTPLMAYGScrdLLKTHFPEGLPELAIAFILRDVLNALEYIHSK 120
                          90       100
                  ....*....|....*....|....*
gi 1384865967 270 KIVHRDIKPSNLLLGDDGHVKIADF 294
Cdd:cd08216   121 GYIHRSVKASHILISGDGKVVLSGL 145
STKc_TGFbR2_like cd14055
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II ...
262-388 5.97e-10

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as TGFbR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. TGFbR2 acts as the receptor for TGFbeta, which is crucial in growth control and homeostasis in many different tissues. It plays roles in regulating apoptosis and in maintaining the balance between self renewal and cell loss. It also plays a key role in maintaining vascular integrity and in regulating responses to genotoxic stress. Mutations in TGFbR2 can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. The TGFbR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270957 [Multi-domain]  Cd Length: 295  Bit Score: 60.47  E-value: 5.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLHC-------QK--IVHRDIKPSNLLLGDDGHVKIADFGVS----NQFEGNDAQLSSTAGTPAFMAPEAIsDSG-- 326
Cdd:cd14055   110 GLAHLHSdrtpcgrPKipIAHRDLKSSNILVKNDGTCVLADFGLAlrldPSLSVDELANSGQVGTARYMAPEAL-ESRvn 188
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1384865967 327 ----QSFsgKALDVWATGVTLY-----CFVYGKcpfIDDYILTLHRKIkneavvfPEEPEVsEDLKDLILR 388
Cdd:cd14055   189 ledlESF--KQIDVYSMALVLWemasrCEASGE---VKPYELPFGSKV-------RERPCV-ESMKDLVLR 246
STKc_ACVR2 cd14053
Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the ...
198-344 9.26e-10

Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as ACVR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. Vertebrates contain two ACVR2 proteins, ACVR2a (or ActRIIA) and ACVR2b (or ActRIIB). The ACVR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270955 [Multi-domain]  Cd Length: 290  Bit Score: 59.65  E-value: 9.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLI--EVLDDPAEDNLYLVFDLLRKGPVmevpCDkpfpeeqarlYLR--------------DIIL 261
Cdd:cd14053    38 REIYSLPGMKHENILQFIgaEKHGESLEAEYWLITEFHERGSL----CD----------YLKgnviswnelckiaeSMAR 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLH-------CQK---IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQ--LSSTAGTPAFMAPE----AISDS 325
Cdd:cd14053   104 GLAYLHedipatnGGHkpsIAHRDFKSKNVLLKSDLTACIADFGLALKFEPGKSCgdTHGQVGTRRYMAPEvlegAINFT 183
                         170
                  ....*....|....*....
gi 1384865967 326 GQSFsgKALDVWATGVTLY 344
Cdd:cd14053   184 RDAF--LRIDMYAMGLVLW 200
PTKc_HER4 cd05110
Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the ...
199-353 9.91e-10

Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER4 (ErbB4) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands that bind HER4 fall into two groups, the neuregulins (or heregulins) and some EGFR (HER1) ligands including betacellulin, HBEGF, and epiregulin. All four neuregulins (NRG1-4) interact with HER4. Upon ligand binding, HER4 forms homo- or heterodimers with other HER proteins. HER4 is essential in embryonic development. It is implicated in mammary gland, cardiac, and neural development. As a postsynaptic receptor of NRG1, HER4 plays an important role in synaptic plasticity and maturation. The impairment of NRG1/HER4 signaling may contribute to schizophrenia. The HER4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173655 [Multi-domain]  Cd Length: 303  Bit Score: 59.69  E-value: 9.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDPAednLYLVFDLLRKGPVME-VPCDKPFPEEQARL-YLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd05110    59 EALIMASMDHPHLVRLLGVCLSPT---IQLVTQLMPHGCLLDyVHEHKDNIGSQLLLnWCVQIAKGMMYLEERRLVHRDL 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTP--AFMAPEAIsdSGQSFSGKAlDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05110   136 AARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMpiKWMALECI--HYRKFTHQS-DVWSYGVTIWeLMTFGGKPY 212
PTKc_PDGFR_alpha cd05105
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; ...
262-403 1.04e-09

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR alpha is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR alpha forms homodimers or heterodimers with PDGFR beta, depending on the nature of the PDGF ligand. PDGF-AA, PDGF-AB, and PDGF-CC induce PDGFR alpha homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR alpha signaling is important in the formation of lung alveoli, intestinal villi, mesenchymal dermis, and hair follicles, as well as in the development of oligodendrocytes, retinal astrocytes, neural crest cells, and testicular cells. Aberrant PDGFR alpha expression is associated with some human cancers. Mutations in PDGFR alpha have been found within a subset of gastrointestinal stromal tumors (GISTs). An active fusion protein FIP1L1-PDGFR alpha, derived from interstitial deletion, is associated with idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia. The PDGFR alpha subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173653 [Multi-domain]  Cd Length: 400  Bit Score: 60.42  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF--EGNDAQLSSTAGTPAFMAPEAISDsgqSFSGKALDVWAT 339
Cdd:cd05105   249 GMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDImhDSNYVSKGSTFLPVKWMAPESIFD---NLYTTLSDVWSY 325
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 340 GVTLY-CFVYGKCPF----IDDyilTLHRKIKNEAVVfpEEPE-VSEDLKDLILRMLDKNPETR---IGVSDI 403
Cdd:cd05105   326 GILLWeIFSLGGTPYpgmiVDS---TFYNKIKSGYRM--AKPDhATQEVYDIMVKCWNSEPEKRpsfLHLSDI 393
PTKc_EphR_A2 cd05063
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the ...
199-403 1.08e-09

Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The EphA2 receptor is overexpressed in tumor cells and tumor blood vessels in a variety of cancers including breast, prostate, lung, and colon. As a result, it is an attractive target for drug design since its inhibition could affect several aspects of tumor progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 133194 [Multi-domain]  Cd Length: 268  Bit Score: 59.22  E-value: 1.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVMEVPCDK--PFPEEQARLYLRDIILGLEYLHCQKIVHRDI 276
Cdd:cd05063    56 EASIMGQFSHHNIIRLEGVVTK--FKPAMIITEYMENGALDKYLRDHdgEFSSYQLVGMLRGIAAGMKYLSDMNYVHRDL 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 277 KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPA---FMAPEAIsdSGQSFSgKALDVWATGVTLY-CFVYGKCP 352
Cdd:cd05063   134 AARNILVNSNLECKVSDFGLSRVLEDDPEGTYTTSGGKIpirWTAPEAI--AYRKFT-SASDVWSFGIVMWeVMSFGERP 210
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 353 FIDdyiLTLHRKIK--NEAVVFPEEPEVSEDLKDLILRMLDKNPETRIGVSDI 403
Cdd:cd05063   211 YWD---MSNHEVMKaiNDGFRLPAPMDCPSAVYQLMLQCWQQDRARRPRFVDI 260
PTKc_TrkC cd05094
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C; PTKs catalyze ...
198-404 1.14e-09

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase C; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkC is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkC to its ligand, neurotrophin 3 (NT3), results in receptor oligomerization and activation of the catalytic domain. TrkC is broadly expressed in the nervous system and in some non-neural tissues including the developing heart. NT3/TrkC signaling plays an important role in the innervation of the cardiac conducting system and the development of smooth muscle cells. Mice deficient with NT3 and TrkC have multiple heart defects. NT3/TrkC signaling is also critical for the development and maintenance of enteric neurons that are important for the control of gut peristalsis. The TrkC subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270676 [Multi-domain]  Cd Length: 287  Bit Score: 59.25  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKG----------PVMEVPCDKPFPEEQARLYLRD-------II 260
Cdd:cd05094    56 REAELLTNLQHDHIVKFYGVCGD--GDPLIMVFEYMKHGdlnkflrahgPDAMILVDGQPRQAKGELGLSQmlhiatqIA 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 261 LGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGND-AQLSSTAGTPA-FMAPEAIsdSGQSFSGKAlDVWA 338
Cdd:cd05094   134 SGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDyYRVGGHTMLPIrWMPPESI--MYRKFTTES-DVWS 210
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 339 TGVTLY-CFVYGKCPFIDDYILTLHRKIKNEAVVfpEEPEV-SEDLKDLILRMLDKNPETRIGVSDIK 404
Cdd:cd05094   211 FGVILWeIFTYGKQPWFQLSNTEVIECITQGRVL--ERPRVcPKEVYDIMLGCWQREPQQRLNIKEIY 276
PTKc_Tec_Rlk cd05114
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular ...
194-353 1.33e-09

Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tec and Rlk (also named Txk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. Instead of PH, Rlk contains an N-terminal cysteine-rich region. In addition to PH, Tec also contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Tec kinases are expressed mainly by haematopoietic cells. Tec is more widely-expressed than other Tec-like subfamily kinases. It is found in endothelial cells, both B- and T-cells, and a variety of myeloid cells including mast cells, erythroid cells, platelets, macrophages and neutrophils. Rlk is expressed in T-cells and mast cell lines. Tec and Rlk are both key components of T-cell receptor (TCR) signaling. They are important in TCR-stimulated proliferation, IL-2 production and phopholipase C-gamma1 activation. The Tec/Rlk subfamily is part of a larger superfamily, that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270685 [Multi-domain]  Cd Length: 260  Bit Score: 58.72  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERVYQEIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGpvmevpCDKPFPEEQARLYLRDIIL--------GLEY 265
Cdd:cd05114    44 EDFIEEAKVMMKLTHPKLVQLYGVCTQ--QKPIYIVTEFMENG------CLLNYLRQRRGKLSRDMLLsmcqdvceGMEY 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPA-FMAPEAISDSgqSFSGKAlDVWATGVTLY 344
Cdd:cd05114   116 LERNNFIHRDLAARNCLVNDTGVVKVSDFGMTRYVLDDQYTSSSGAKFPVkWSPPEVFNYS--KFSSKS-DVWSFGVLMW 192
                         170
                  ....*....|
gi 1384865967 345 -CFVYGKCPF 353
Cdd:cd05114   193 eVFTEGKMPF 202
PKc_DYRK cd14210
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
199-303 1.36e-09

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase; Protein Kinases (PKs), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK) subfamily, catalytic (c) domain. Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. The DYRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein S/T PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. Vertebrates contain multiple DYRKs (DYRK1-4) and mammals contain two types of DYRK1 proteins, DYRK1A and DYRK1B. DYRK1A is involved in neuronal differentiation and is implicated in the pathogenesis of DS (Down syndrome). DYRK1B plays a critical role in muscle differentiation by regulating transcription, cell motility, survival, and cell cycle progression. It is overexpressed in many solid tumors where it acts as a tumor survival factor. DYRK2 promotes apoptosis in response to DNA damage by phosphorylating the tumor suppressor p53, while DYRK3 promotes cell survival by phosphorylating SIRT1 and promoting p53 deacetylation. DYRK4 is a testis-specific kinase that may function during spermiogenesis.


Pssm-ID: 271112 [Multi-domain]  Cd Length: 311  Bit Score: 59.48  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKL------DHVNVVKLI-------------EVLDDpaedNLYlvfDLLRKGPVmevpcdKPFPEEQARLYLRDI 259
Cdd:cd14210    59 EVKILKHLndndpdDKHNIVRYKdsfifrghlcivfELLSI----NLY---ELLKSNNF------QGLSLSLIRKFAKQI 125
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1384865967 260 ILGLEYLHCQKIVHRDIKPSNLLLGDDGH--VKIADFGvSNQFEGN 303
Cdd:cd14210   126 LQALQFLHKLNIIHCDLKPENILLKQPSKssIKVIDFG-SSCFEGE 170
PTKc_EphR cd05033
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
199-355 1.40e-09

Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They can be classified into two classes (EphA and EphB), according to their extracellular sequences, which largely correspond to binding preferences for either GPI-anchored ephrin-A ligands or transmembrane ephrin-B ligands. Vertebrates have ten EphA and six EphB receptors, which display promiscuous ligand interactions within each class. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. This allows ephrin/EphR dimers to form, leading to the activation of the intracellular tyr kinase domain. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). The main effect of ephrin/EphR interaction is cell-cell repulsion or adhesion. Ephrin/EphR signaling is important in neural development and plasticity, cell morphogenesis and proliferation, cell-fate determination, embryonic development, tissue patterning, and angiogenesis.The EphR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270629 [Multi-domain]  Cd Length: 266  Bit Score: 58.92  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLddpaednlylvfdlLRKGPVMEVP--------------CDKPFPEEQARLYLRDIILGLE 264
Cdd:cd05033    55 EASIMGQFDHPNVIRLEGVV--------------TKSRPVMIVTeymengsldkflreNDGKFTVTQLVGMLRGIASGMK 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 265 YLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG-TPA-FMAPEAISDsgQSFSgKALDVWATGVT 342
Cdd:cd05033   121 YLSEMNYVHRDLAARNILVNSDLVCKVSDFGLSRRLEDSEATYTTKGGkIPIrWTAPEAIAY--RKFT-SASDVWSFGIV 197
                         170
                  ....*....|....
gi 1384865967 343 LY-CFVYGKCPFID 355
Cdd:cd05033   198 MWeVMSYGERPYWD 211
PK_KSR cd14063
Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to ...
193-404 1.60e-09

Pseudokinase domain of Kinase Suppressor of Ras; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. KSR is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. KSR proteins regulate the assembly and activation of the Raf/MEK/ERK module upon Ras activation at the membrane by direct association of its components. They are widely regarded as pseudokinases, but there is some debate in this designation as a few groups have reported detecting kinase catalytic activity for KSRs, specifically KSR1. Vertebrates contain two KSR proteins, KSR1 and KSR2. The KSR subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270965 [Multi-domain]  Cd Length: 271  Bit Score: 58.90  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEVPCDK--PFPEEQARLYLRDIILGLEYLHCQK 270
Cdd:cd14063    40 LEAFKEEVAAYKNTRHDNLVLFMGACMDP--PHLAIVTSLCKGRTLYSLIHERkeKFDFNKTVQIAQQICQGMGYLHAKG 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLgDDGHVKIADFGVSN-----QFEGNDAQLSSTAGTPAFMAPEAI--------SDSGQSFSgKALDVW 337
Cdd:cd14063   118 IIHKDLKSKNIFL-ENGRVVITDFGLFSlsgllQPGRREDTLVIPNGWLCYLAPEIIralspdldFEESLPFT-KASDVY 195
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 338 ATGVTLYCFVYGKCPFiddyiltlhRKIKNEAVVF---------PEEPEVSEDLKDLILRMLDKNPETRIGVSDIK 404
Cdd:cd14063   196 AFGTVWYELLAGRWPF---------KEQPAESIIWqvgcgkkqsLSQLDIGREVKDILMQCWAYDPEKRPTFSDLL 262
PTK_HER3 cd05111
Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR ...
206-353 1.62e-09

Pseudokinase domain of the Protein Tyrosine Kinase, HER3; HER3 (ErbB3) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER3 contains an impaired tyr kinase domain, which lacks crucial residues for catalytic activity against exogenous substrates but is still able to bind ATP and autophosphorylate. HER3 binds the neuregulin ligands, NRG1 and NRG2, and it relies on its heterodimerization partners for activity following ligand binding. The HER2-HER3 heterodimer constitutes a high affinity co-receptor capable of potent mitogenic signaling. HER3 participates in a signaling pathway involved in the proliferation, survival, adhesion, and motility of tumor cells. The HER3 subfamily is part of a larger superfamily that includes other pseudokinases and the the catalytic domains of active kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173656 [Multi-domain]  Cd Length: 279  Bit Score: 58.81  E-value: 1.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 206 LDHVNVVKLIEVLDDPAednLYLVFDLLRKGPVME-VPCDKPFPEEQARL-YLRDIILGLEYLHCQKIVHRDIKPSNLLL 283
Cdd:cd05111    66 LDHAYIVRLLGICPGAS---LQLVTQLLPLGSLLDhVRQHRGSLGPQLLLnWCVQIAKGMYYLEEHRMVHRNLAARNVLL 142
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 284 GDDGHVKIADFGVSNQFEGNDAQ-LSSTAGTP-AFMAPEAI---SDSGQSfsgkalDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05111   143 KSPSQVQVADFGVADLLYPDDKKyFYSEAKTPiKWMALESIhfgKYTHQS------DVWSYGVTVWeMMTFGAEPY 212
STKc_PDIK1L cd13977
Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs ...
263-397 1.67e-09

Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDIK1L is also called STK35 or CLIK-1. It is predominantly a nuclear protein which is capable of autophosphorylation. Through its interaction with the PDZ-LIM protein CLP-36, it is localized to actin stress fibers. The PDIK1L subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270879 [Multi-domain]  Cd Length: 322  Bit Score: 59.11  E-value: 1.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 263 LEYLHCQKIVHRDIKPSNLLLG---DDGHVKIADFGVSNQFEG-----------NDAQLSSTAGTPAFMAPEAISDsgqS 328
Cdd:cd13977   147 LAFLHRNQIVHRDLKPDNILIShkrGEPILKVADFGLSKVCSGsglnpeepanvNKHFLSSACGSDFYMAPEVWEG---H 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 329 FSGKAlDVWATGVTLYCFVYgKCPFIDDYILT--LHRKIKNEAVVFP------EEPEV------------SEDLKDLILR 388
Cdd:cd13977   224 YTAKA-DIFALGIIIWAMVE-RITFRDGETKKelLGTYIQQGKEIVPlgeallENPKLelqiplkkkksmNDDMKQLLRD 301

                  ....*....
gi 1384865967 389 MLDKNPETR 397
Cdd:cd13977   302 MLAANPQER 310
PTKc_RET cd05045
Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs ...
199-403 1.85e-09

Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. RET is a receptor PTK (RTK) containing an extracellular region with four cadherin-like repeats, a calcium-binding site, and a cysteine-rich domain, a transmembrane segment, and an intracellular catalytic domain. It is part of a multisubunit complex that binds glial-derived neurotropic factor (GDNF) family ligands (GFLs) including GDNF, neurturin, artemin, and persephin. GFLs bind RET along with four GPI-anchored coreceptors, bringing two RET molecules together, leading to autophosphorylation, activation, and intracellular signaling. RET is essential for the development of the sympathetic, parasympathetic and enteric nervous systems, and the kidney. RET disruption by germline mutations causes diseases in humans including congenital aganglionosis of the gastrointestinal tract (Hirschsprung's disease) and three related inherited cancers: multiple endocrine neoplasia type 2A (MEN2A), MEN2B, and familial medullary thyroid carcinoma. The RET subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173631 [Multi-domain]  Cd Length: 290  Bit Score: 58.82  E-value: 1.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDdpAEDNLYLVFDLLRKGPVM-------EVPC-----------DKPFPEEQARLYLRDII 260
Cdd:cd05045    53 EFNLLKQVNHPHVIKLYGACS--QDGPLLLIVEYAKYGSLRsflresrKVGPsylgsdgnrnsSYLDNPDERALTMGDLI 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 261 L-------GLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG-TPA-FMAPEAISDsgQSFSG 331
Cdd:cd05045   131 SfawqisrGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGrIPVkWMAIESLFD--HIYTT 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 332 KAlDVWATGVTLYCFV-YGKCPF-------IDDYILTLHRKikneavvfpEEPE-VSEDLKDLILRMLDKNPETRIGVSD 402
Cdd:cd05045   209 QS-DVWSFGVLLWEIVtLGGNPYpgiaperLFNLLKTGYRM---------ERPEnCSEEMYNLMLTCWKQEPDKRPTFAD 278

                  .
gi 1384865967 403 I 403
Cdd:cd05045   279 I 279
PTKc_InsR cd05061
Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer ...
194-344 1.87e-09

Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. InsR is a receptor PTK (RTK) that is composed of two alphabeta heterodimers. Binding of the insulin ligand to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR signaling plays an important role in many cellular processes including glucose homeostasis, glycogen synthesis, lipid and protein metabolism, ion and amino acid transport, cell cycle and proliferation, cell differentiation, gene transcription, and nitric oxide synthesis. Insulin resistance, caused by abnormalities in InsR signaling, has been described in diabetes, hypertension, cardiovascular disease, metabolic syndrome, heart failure, and female infertility. The InsR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133192 [Multi-domain]  Cd Length: 288  Bit Score: 58.83  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 194 ERV--YQEIAILKKLDHVNVVKLIEVLDDpAEDNLyLVFDLLRKG----------PVMEVPCDKPFPEEQARLYLR-DII 260
Cdd:cd05061    52 ERIefLNEASVMKGFTCHHVVRLLGVVSK-GQPTL-VVMELMAHGdlksylrslrPEAENNPGRPPPTLQEMIQMAaEIA 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 261 LGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG-TPA-FMAPEAISDSgqSFSGKAlDVWA 338
Cdd:cd05061   130 DGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGlLPVrWMAPESLKDG--VFTTSS-DMWS 206

                  ....*.
gi 1384865967 339 TGVTLY 344
Cdd:cd05061   207 FGVVLW 212
STKc_LRRK2 cd14068
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze ...
198-397 2.18e-09

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK2 is one of two vertebrate LRRKs which show complementary expression in the brain. Mutations in LRRK2, found in the kinase, ROC-COR, and WD40 domains, are linked to both familial and sporadic forms of Parkinson's disease. The most prevalent mutation, G2019S located in the activation loop of the kinase domain, increases kinase activity. The R1441C/G mutations in the GTPase domain have also been reported to influence kinase activity. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270970 [Multi-domain]  Cd Length: 252  Bit Score: 58.04  E-value: 2.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPAednlYLVFDLLRKGPVmevpcDKPFPEEQA---RLYLRDIIL----GLEYLHCQK 270
Cdd:cd14068    36 QELVVLSHLHHPSLVALLAAGTAPR----MLVMELAPKGSL-----DALLQQDNAsltRTLQHRIALhvadGLRYLHSAM 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLLGD---DGHV--KIADFGVSNQFegNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKALDVWATGVTLYc 345
Cdd:cd14068   107 IIYRDLKPHNVLLFTlypNCAIiaKIADYGIAQYC--CRMGIKTSEGTPGFRAPEVA--RGNVIYNQQADVYSFGLLLY- 181
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 346 fvygkcpfiddYILTLHRKIkNEAVVFP---EEPEVSEDLKD---------------LILRMLDKNPETR 397
Cdd:cd14068   182 -----------DILTCGERI-VEGLKFPnefDELAIQGKLPDpvkeygcapwpgveaLIKDCLKENPQCR 239
PTKc_Tie1 cd05089
Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; ...
199-353 2.46e-09

Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; Tie1; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie1 is a receptor tyr kinase (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. No specific ligand has been identified for Tie1, although the angiopoietin, Ang-1, binds to Tie1 through integrins at high concentrations. In vivo studies of Tie1 show that it is critical in vascular development.


Pssm-ID: 270671 [Multi-domain]  Cd Length: 297  Bit Score: 58.47  E-value: 2.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKL-DHVNVVKLIEVLDDpaEDNLYL---------VFDLLRKGPVMEVpcDKPFPEE----------QARLYLRD 258
Cdd:cd05089    52 ELEVLCKLgHHPNIINLLGACEN--RGYLYIaieyapygnLLDFLRKSRVLET--DPAFAKEhgtastltsqQLLQFASD 127
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 259 IILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSnqfEGNDAQLSSTAGT-PA-FMAPEAISDSgqSFSGKAlDV 336
Cdd:cd05089   128 VAKGMQYLSEKQFIHRDLAARNVLVGENLVSKIADFGLS---RGEEVYVKKTMGRlPVrWMAIESLNYS--VYTTKS-DV 201
                         170
                  ....*....|....*...
gi 1384865967 337 WATGVTLYCFV-YGKCPF 353
Cdd:cd05089   202 WSFGVLLWEIVsLGGTPY 219
STKc_RIP2 cd14026
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze ...
196-355 2.53e-09

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP2, also called RICK or CARDIAK, harbors a C-terminal Caspase Activation and Recruitment domain (CARD) belonging to the Death domain (DD) superfamily. It functions as an effector kinase downstream of the pattern recognition receptors from the Nod-like (NLR) family, Nod1 and Nod2, which recognizes bacterial peptidoglycans released upon infection. RIP2 may also be involved in regulating wound healing and keratinocyte proliferation. RIP kinases serve as essential sensors of cellular stress. The RIP2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270928 [Multi-domain]  Cd Length: 284  Bit Score: 58.39  E-value: 2.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 196 VYQEIAILKKLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEVPCDKP-FPEEQARLYLR---DIILGLEYLHCQK- 270
Cdd:cd14026    44 LLKEAEILHKARFSYILPILGICNEP--EFLGIVTEYMTNGSLNELLHEKDiYPDVAWPLRLRilyEIALGVNYLHNMSp 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 -IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSST-----AGTPAFMAPEAISDSGQSFSGKALDVWATGVTLY 344
Cdd:cd14026   122 pLLHHDLKTQNILLDGEFHVKIADFGLSKWRQLSISQSRSSksapeGGTIIYMPPEEYEPSQKRRASVKHDIYSYAIIMW 201
                         170
                  ....*....|.
gi 1384865967 345 CFVYGKCPFID 355
Cdd:cd14026   202 EVLSRKIPFEE 212
PTKc_ALK_LTK cd05036
Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte ...
199-353 3.47e-09

Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyr residues in protein substrates. ALK and LTK are orphan receptor PTKs (RTKs) whose ligands are not yet well-defined. ALK appears to play an important role in mammalian neural development as well as visceral muscle differentiation in Drosophila. ALK is aberrantly expressed as fusion proteins, due to chromosomal translocations, in about 60% of anaplastic large cell lymphomas (ALCLs). ALK fusion proteins are also found in rare cases of diffuse large B cell lymphomas (DLBCLs). LTK is mainly expressed in B lymphocytes and neuronal tissues. It is important in cell proliferation and survival. Transgenic mice expressing TLK display retarded growth and high mortality rate. In addition, a polymorphism in mouse and human LTK is implicated in the pathogenesis of systemic lupus erythematosus. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. They are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The ALK/LTK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270632 [Multi-domain]  Cd Length: 277  Bit Score: 57.78  E-value: 3.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYL-------RDIILGLEYLHCQK 270
Cdd:cd05036    59 EALIMSKFNHPNIVRCIGVCFQ--RLPRFILLELMAGGDLKSfLRENRPRPEQPSSLTMldllqlaQDVAKGCRYLEENH 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 271 IVHRDIKPSNLLL---GDDGHVKIADFGVSNQF-------EGNDAQLsstagtPA-FMAPEAISDSgqSFSGKAlDVWAT 339
Cdd:cd05036   137 FIHRDIAARNCLLtckGPGRVAKIGDFGMARDIyradyyrKGGKAML------PVkWMPPEAFLDG--IFTSKT-DVWSF 207
                         170
                  ....*....|....*
gi 1384865967 340 GVTLY-CFVYGKCPF 353
Cdd:cd05036   208 GVLLWeIFSLGYMPY 222
PTKc_Ror2 cd05091
Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor ...
188-353 4.31e-09

Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Ror2 plays important roles in skeletal and heart formation. Ror2-deficient mice show widespread bone abnormalities, ventricular defects in the heart, and respiratory dysfunction. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Ror2 is also implicated in neural development. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. The Ror2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270673 [Multi-domain]  Cd Length: 284  Bit Score: 57.72  E-value: 4.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 188 KQLLPLERVYQEIAILK-KLDHVNVVKLIEVLDDpaEDNLYLVFDLLRKGP-----VMEVPC--------DKPFPE--EQ 251
Cdd:cd05091    47 KAEGPLREEFRHEAMLRsRLQHPNIVCLLGVVTK--EQPMSMIFSYCSHGDlheflVMRSPHsdvgstddDKTVKStlEP 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 252 ARLY--LRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGND-AQLSSTAGTPA-FMAPEAISDSGQ 327
Cdd:cd05091   125 ADFLhiVTQIAAGMEYLSSHHVVHKDLATRNVLVFDKLNVKISDLGLFREVYAADyYKLMGNSLLPIrWMSPEAIMYGKF 204
                         170       180
                  ....*....|....*....|....*..
gi 1384865967 328 SFSGkalDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05091   205 SIDS---DIWSYGVVLWeVFSYGLQPY 228
PHA03212 PHA03212
serine/threonine kinase US3; Provisional
257-344 4.34e-09

serine/threonine kinase US3; Provisional


Pssm-ID: 165478 [Multi-domain]  Cd Length: 391  Bit Score: 58.47  E-value: 4.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 257 RDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS--------NQFEGndaqlssTAGTPAFMAPEAISdsgQS 328
Cdd:PHA03212  189 RSVLRAIQYLHENRIIHRDIKAENIFINHPGDVCLGDFGAAcfpvdinaNKYYG-------WAGTIATNAPELLA---RD 258
                          90
                  ....*....|....*.
gi 1384865967 329 FSGKALDVWATGVTLY 344
Cdd:PHA03212  259 PYGPAVDIWSAGIVLF 274
PTKc_VEGFR3 cd05102
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; ...
246-353 8.04e-09

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR3 (or Flt4) preferentially binds the ligands VEGFC and VEGFD. VEGFR3 is essential for lymphatic endothelial cell (EC) development and function. It has been shown to regulate adaptive immunity during corneal transplantation. VEGFR3 is upregulated on blood vascular ECs in pathological conditions such as vascular tumors and the periphery of solid tumors. It plays a role in cancer progression and lymph node metastasis. Missense mutations in the VEGFR3 gene are associated with primary human lymphedema. VEGFR3 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270680 [Multi-domain]  Cd Length: 336  Bit Score: 57.30  E-value: 8.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 246 PFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQ-FEGNDAQLSSTAGTP-AFMAPEAIS 323
Cdd:cd05102   168 PLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARDiYKDPDYVRKGSARLPlKWMAPESIF 247
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1384865967 324 D---SGQSfsgkalDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05102   248 DkvyTTQS------DVWSFGVLLWeIFSLGASPY 275
STKc_KIS cd14020
Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called ...
257-398 8.40e-09

Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. KIS (or UHMK1) contains an N-terminal kinase domain and a C-terminal domain with a UHM motif, a protein interaction motif initially found in the pre-mRNA splicing factor U2AF. It phosphorylates the splicing factor SF1, which enhances binding to the splice site to promote spliceosome assembly. KIS was first identified as a kinase that interacts with stathmin, a phosphoprotein that plays a role in axon development and microtubule dynamics. It localizes in RNA granules in neurons and is important in neurite outgrowth. The KIS/UHMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270922 [Multi-domain]  Cd Length: 285  Bit Score: 56.87  E-value: 8.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 257 RDIILGLEYLHCQKIVHRDIKPSNLLL-GDDGHVKIADFGVSNQfEGN-DAQLSSTAGtpaFMAPEA-----ISDSG-QS 328
Cdd:cd14020   117 RDVLEALAFLHHEGYVHADLKPRNILWsAEDECFKLIDFGLSFK-EGNqDVKYIQTDG---YRAPEAelqncLAQAGlQS 192
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 329 FSG--KALDVWATGVTLYCFVYG--------KCPFIDDYILTLHRKIKNEAVVFPEEPevSEDLKDLILRMLDKNPETRI 398
Cdd:cd14020   193 ETEctSAVDLWSLGIVLLEMFSGmklkhtvrSQEWKDNSSAIIDHIFASNAVVNPAIP--AYHLRDLIKSMLHNDPGKRA 270
STKc_TGFbR_I cd14056
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type ...
248-355 9.44e-09

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type I Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of type I receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation through trans-phosphorylation by type II receptors, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. They are inhibited by the immunophilin FKBP12, which is thought to control leaky signaling caused by receptor oligomerization in the absence of ligand. The TGFbR-I subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270958 [Multi-domain]  Cd Length: 287  Bit Score: 56.51  E-value: 9.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 248 PEEQARLyLRDIILGLEYLHCQ--------KIVHRDIKPSNLLLGDDGHVKIADFGV----SNQFEGNDAQLSSTAGTPA 315
Cdd:cd14056    91 TEEALRL-AYSAASGLAHLHTEivgtqgkpAIAHRDLKSKNILVKRDGTCCIADLGLavryDSDTNTIDIPPNPRVGTKR 169
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1384865967 316 FMAPEAISDS--GQSFSG-KALDVWATGVTLY-----CFVYGKC-----PFID 355
Cdd:cd14056   170 YMAPEVLDDSinPKSFESfKMADIYSFGLVLWeiarrCEIGGIAeeyqlPYFG 222
STKc_BMPR1 cd14144
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; ...
262-386 1.17e-08

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1 functions as a receptor for morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Vertebrates contain two type I BMP receptors, BMPR1a and BMPR1b. BMPR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that also includes TGFbeta, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271046 [Multi-domain]  Cd Length: 287  Bit Score: 56.33  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLHCQ--------KIVHRDIKPSNLLLGDDGHVKIADFGVSNQF--EGN--DAQLSSTAGTPAFMAPEAISDS--GQ 327
Cdd:cd14144   104 GLAHLHTEifgtqgkpAIAHRDIKSKNILVKKNGTCCIADLGLAVKFisETNevDLPPNTRVGTKRYMAPEVLDESlnRN 183
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1384865967 328 SFSG-KALDVWATGVTLY-----CFVYGKCpfiDDYILTLHrkiknEAVvfPEEPEVsEDLKDLI 386
Cdd:cd14144   184 HFDAyKMADMYSFGLVLWeiarrCISGGIV---EEYQLPYY-----DAV--PSDPSY-EDMRRVV 237
PTKc_c-ros cd05044
Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the ...
198-397 1.26e-08

Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily contains c-ros, Sevenless, and similar proteins. The proto-oncogene c-ros encodes an orphan receptor PTK (RTK) with an unknown ligand. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. C-ros is expressed in embryonic cells of the kidney, intestine and lung, but disappears soon after birth. It persists only in the adult epididymis. Male mice bearing inactive mutations of c-ros lack the initial segment of the epididymis and are infertile. The Drosophila protein, Sevenless, is required for the specification of the R7 photoreceptor cell during eye development. The c-ros subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270640 [Multi-domain]  Cd Length: 268  Bit Score: 55.89  E-value: 1.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEV-LDDpaeDNLYLVFDLLRKGPVME-VPCDKPFPEEQARLYLRDII-------LGLEYLHC 268
Cdd:cd05044    48 KEAHLMSNFKHPNILKLLGVcLDN---DPQYIILELMEGGDLLSyLRAARPTAFTPPLLTLKDLLsicvdvaKGCVYLED 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 269 QKIVHRDIKPSNLLLGDDGH----VKIADFGVSNQFEGNDAQLSSTAGT-PA-FMAPEAISD---SGQSfsgkalDVWAT 339
Cdd:cd05044   125 MHFVHRDLAARNCLVSSKDYrervVKIGDFGLARDIYKNDYYRKEGEGLlPVrWMAPESLVDgvfTTQS------DVWAF 198
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 340 GVTLY-CFVYGKCPFIDDYILTLHRKIKNEAVVfpEEPE-VSEDLKDLILRMLDKNPETR 397
Cdd:cd05044   199 GVLMWeILTLGQQPYPARNNLEVLHFVRAGGRL--DQPDnCPDDLYELMLRCWSTDPEER 256
PTKc_EphR_A cd05066
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze ...
199-355 1.34e-08

Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of most class EphA receptors including EphA3, EphA4, EphA5, and EphA7, but excluding EphA1, EphA2 and EphA10. Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. One exception is EphA4, which also binds ephrins-B2/B3. EphA receptors and ephrin-A ligands are expressed in multiple areas of the developing brain, especially in the retina and tectum. They are part of a system controlling retinotectal mapping. EphRs comprise the largest subfamily of receptor PTKs (RTKs). EphRs contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270651 [Multi-domain]  Cd Length: 267  Bit Score: 56.03  E-value: 1.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKL-------------IEVLDDPAEDNLylvfdlLRKGpvmevpcDKPFPEEQARLYLRDIILGLEY 265
Cdd:cd05066    55 EASIMGQFDHPNIIHLegvvtrskpvmivTEYMENGSLDAF------LRKH-------DGQFTVIQLVGMLRGIASGMKY 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGN-DAQLSSTAGT-PA-FMAPEAIsdSGQSFSgKALDVWATGVT 342
Cdd:cd05066   122 LSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDpEAAYTTRGGKiPIrWTAPEAI--AYRKFT-SASDVWSYGIV 198
                         170
                  ....*....|....
gi 1384865967 343 LY-CFVYGKCPFID 355
Cdd:cd05066   199 MWeVMSYGERPYWE 212
PTKc_TrkA cd05092
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze ...
130-353 1.43e-08

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkA is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkA to its ligand, nerve growth factor (NGF), results in receptor oligomerization and activation of the catalytic domain. TrkA is expressed mainly in neural-crest-derived sensory and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons of the central nervous system. It is critical for neuronal growth, differentiation and survival. Alternative TrkA splicing has been implicated as a pivotal regulator of neuroblastoma (NB) behavior. Normal TrkA expression is associated with better NB prognosis, while the hypoxia-regulated TrkAIII splice variant promotes NB pathogenesis and progression. Aberrant TrkA expression has also been demonstrated in non-neural tumors including prostate, breast, lung, and pancreatic cancers. The TrkA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270674 [Multi-domain]  Cd Length: 280  Bit Score: 56.13  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 130 LQSEIGKGAYGVVRLA--YN---ESEDRHYAMKVLSKKKLLKQYGFPRrppprgsqatqggpakqllplervyqEIAILK 204
Cdd:cd05092     9 LKWELGEGAFGKVFLAecHNllpEQDKMLVAVKALKEATESARQDFQR--------------------------EAELLT 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 205 KLDHVNVVKLIEVLDDPaeDNLYLVFDLLRKGPVMEV-----PCDKPFPEEQARLY-----------LRDIILGLEYLHC 268
Cdd:cd05092    63 VLQHQHIVRFYGVCTEG--EPLIMVFEYMRHGDLNRFlrshgPDAKILDGGEGQAPgqltlgqmlqiASQIASGMVYLAS 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 269 QKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGND-AQLSSTAGTPA-FMAPEAIsdSGQSFSGKAlDVWATGVTLY-C 345
Cdd:cd05092   141 LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDyYRVGGRTMLPIrWMPPESI--LYRKFTTES-DIWSFGVVLWeI 217

                  ....*...
gi 1384865967 346 FVYGKCPF 353
Cdd:cd05092   218 FTYGKQPW 225
PK_SCY1_like cd14011
Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein ...
203-408 1.68e-08

Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This subfamily is composed of the catalytically inactive kinases with similarity to yeast Scy1. It includes four mammalian proteins called SCY1-like protein 1 (SCYL1), SCYL2, SCYL3, as well as Testis-EXpressed protein 14 (TEX14). SCYL1 binds to and co-localizes with the membrane trafficking coatomer I (COPI) complex, and regulates COPI-mediated vesicle trafficking. Null mutations in the SCYL1 gene are responsible for the pathology in mdf (muscle-deficient) mice which display progressive motor neuropathy. SCYL2, also called coated vesicle-associated kinase of 104 kDa (CVAK104), is involved in the trafficking of clathrin-coated vesicles. It also binds the HIV-1 accessory protein Vpu and acts as a regulatory factor that promotes the dephosphorylation of Vpu, facilitating the restriction of HIV-1 release. SCYL3, also called ezrin-binding protein PACE-1, may be involved in regulating cell adhesion and migration. TEX14 is required for spermatogenesis and male fertility. It localizes to kinetochores (KT) during mitosis and is a target of the mitotic kinase PLK1. It regulates the maturation of the outer KT and the KT-microtubule attachment. The SCY1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270913 [Multi-domain]  Cd Length: 287  Bit Score: 55.79  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 203 LKKLDHVNVVKLIEVLDDpAEDNLYLV--------FDLLRKGPVMEvpcdKPFPEEQA-RLY-------LRDIILGLEYL 266
Cdd:cd14011    56 LTRLRHPRILTVQHPLEE-SRESLAFAtepvfaslANVLGERDNMP----SPPPELQDyKLYdveikygLLQISEALSFL 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 267 H-CQKIVHRDIKPSNLLLGDDGHVKIADFG--VSNQ--------FEGNDAQLSSTAG-TPAFMAPEAISDSGqsfSGKAL 334
Cdd:cd14011   131 HnDVKLVHGNICPESVVINSNGEWKLAGFDfcISSEqatdqfpyFREYDPNLPPLAQpNLNYLAPEYILSKT---CDPAS 207
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1384865967 335 DVWATGVTLYcFVY--GKCPFIDDYILTLHRKIKNEAVVFPEEP--EVSEDLKDLILRMLDKNPETRIGVSDIKLHPW 408
Cdd:cd14011   208 DMFSLGVLIY-AIYnkGKPLFDCVNNLLSYKKNSNQLRQLSLSLleKVPEELRDHVKTLLNVTPEVRPDAEQLSKIPF 284
PTK_Ryk cd05043
Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase ...
259-355 2.34e-08

Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase (RTK) containing an extracellular region with two leucine-rich motifs, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. The extracellular region of Ryk shows homology to the N-terminal domain of Wnt inhibitory factor-1 (WIF) and serves as the ligand (Wnt) binding domain of Ryk. Ryk is expressed in many different tissues both during development and in adults, suggesting a widespread function. It acts as a chemorepulsive axon guidance receptor of Wnt glycoproteins and is responsible for the establishment of axon tracts during the development of the central nervous system. In addition, studies in mice reveal that Ryk is essential in skeletal, craniofacial, and cardiac development. Thus, it appears Ryk is involved in signal transduction despite its lack of kinase activity. Ryk may function as an accessory protein that modulates the signals coming from catalytically active partner RTKs such as the Eph receptors. The Ryk subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270639 [Multi-domain]  Cd Length: 279  Bit Score: 55.15  E-value: 2.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 259 IILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQ-LSSTAGTP-AFMAPEAISDSGQSFSGkalDV 336
Cdd:cd05043   125 IACGMSYLHRRGVIHKDIAARNCVIDDELQVKITDNALSRDLFPMDYHcLGDNENRPiKWMSLESLVNKEYSSAS---DV 201
                          90       100
                  ....*....|....*....|
gi 1384865967 337 WATGVTLYCFV-YGKCPFID 355
Cdd:cd05043   202 WSFGVLLWELMtLGQTPYVE 221
STKc_TTBK cd14017
Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase; STKs catalyze the ...
127-321 3.16e-08

Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TTBK is a neuron-specific kinase that phosphorylates the microtubule-associated protein tau and promotes its aggregation. Higher vertebrates contain two TTBK proteins, TTBK1 and TTBK2, both of which have been implicated in neurodegeneration. TTBK1 has been linked to Alzheimer's disease (AD) while TTBK2 is associated with spinocerebellar ataxia type 11 (SCA11). Both AD and SCA11 patients show the presence of neurofibrillary tangles in the brain. The Drosophila TTBK homolog, Asator, is an essential protein that localizes to the mitotic spindle during mitosis and may be involved in regulating microtubule dynamics and function. The TTBK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270919 [Multi-domain]  Cd Length: 263  Bit Score: 54.57  E-value: 3.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 127 QYKLQSEIGKGAYGVVRLAYNESEDRHYAMkvlskkkllkqygfprrpppRGSQATQggpAKQLLPLERvyqeiAILKKL 206
Cdd:cd14017     1 RWKVVKKIGGGGFGEIYKVRDVVDGEEVAM--------------------KVESKSQ---PKQVLKMEV-----AVLKKL 52
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 207 ---DHVnvVKLIEVLDDpaEDNLYLVF--------DLLRKGP--VMEVPCdkpfpeeQARLyLRDIILGLEYLHCQKIVH 273
Cdd:cd14017    53 qgkPHF--CRLIGCGRT--ERYNYIVMtllgpnlaELRRSQPrgKFSVST-------TLRL-GIQILKAIEDIHEVGFLH 120
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1384865967 274 RDIKPSNLLLG----DDGHVKIADFGVSNQF---EGNDAQLSSTA----GTPAFMAPEA 321
Cdd:cd14017   121 RDVKPSNFAIGrgpsDERTVYILDFGLARQYtnkDGEVERPPRNAagfrGTVRYASVNA 179
PKc_LIMK_like_unk cd14156
Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs ...
188-352 3.17e-08

Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This group is composed of uncharacterized proteins with similarity to LIMK and Testicular or testis-specific protein kinase (TESK). LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271058 [Multi-domain]  Cd Length: 256  Bit Score: 54.83  E-value: 3.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 188 KQLLPLERVYQEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVMEVPCDKPFP---EEQARLYLrDIILGLE 264
Cdd:cd14156    27 KNDVDQHKIVREISLLQKLSHPNIVRYLGIC--VKDEKLHPILEYVSGGCLEELLAREELPlswREKVELAC-DISRGMV 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 265 YLHCQKIVHRDIKPSNLLLGDDGHVK---IADFGVSNQF----EGNDAQLSSTAGTPAFMAPEAIsdSGQSFSGKaLDVW 337
Cdd:cd14156   104 YLHSKNIYHRDLNSKNCLIRVTPRGReavVTDFGLAREVgempANDPERKLSLVGSAFWMAPEML--RGEPYDRK-VDVF 180
                         170
                  ....*....|....*
gi 1384865967 338 ATGVTLyCFVYGKCP 352
Cdd:cd14156   181 SFGIVL-CEILARIP 194
PTZ00036 PTZ00036
glycogen synthase kinase; Provisional
198-349 4.05e-08

glycogen synthase kinase; Provisional


Pssm-ID: 173333 [Multi-domain]  Cd Length: 440  Bit Score: 55.43  E-value: 4.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLDDPA----EDNLYLvfdllrkGPVME-VP------------CDKPFPEEQARLYLRDII 260
Cdd:PTZ00036  108 RELLIMKNLNHINIIFLKDYYYTECfkknEKNIFL-------NVVMEfIPqtvhkymkhyarNNHALPLFLVKLYSYQLC 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 261 LGLEYLHCQKIVHRDIKPSNLLLGDDGH-VKIADFGVSNQFEGNDAQLSSTAgTPAFMAPEAIsdSGQSFSGKALDVWAT 339
Cdd:PTZ00036  181 RALAYIHSKFICHRDLKPQNLLIDPNTHtLKLCDFGSAKNLLAGQRSVSYIC-SRFYRAPELM--LGATNYTTHIDLWSL 257
                         170
                  ....*....|
gi 1384865967 340 GVTLYCFVYG 349
Cdd:PTZ00036  258 GCIIAEMILG 267
PTKc_Met_Ron cd05058
Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of ...
193-397 4.27e-08

Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Met and Ron are receptor PTKs (RTKs) composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. Met binds to the ligand, hepatocyte growth factor/scatter factor (HGF/SF), and is also called the HGF receptor. HGF/Met signaling plays a role in growth, transformation, cell motility, invasion, metastasis, angiogenesis, wound healing, and tissue regeneration. Aberrant expression of Met through mutations or gene amplification is associated with many human cancers including hereditary papillary renal and gastric carcinomas. The ligand for Ron is macrophage stimulating protein (MSP). Ron signaling is important in regulating cell motility, adhesion, proliferation, and apoptosis. Aberrant Ron expression is implicated in tumorigenesis and metastasis. The Met/Ron subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270649 [Multi-domain]  Cd Length: 262  Bit Score: 54.40  E-value: 4.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 193 LERVYQEIAILKKLDHVNVVKLIEVLDdPAEDNLYLVFDLLRKGPVMEVpcdkpFPEEQARLYLRDII-------LGLEY 265
Cdd:cd05058    40 VEQFLKEGIIMKDFSHPNVLSLLGICL-PSEGSPLVVLPYMKHGDLRNF-----IRSETHNPTVKDLIgfglqvaKGMEY 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF---EGNDAQLSSTAGTPA-FMAPEAISDsgQSFSGKAlDVWATGV 341
Cdd:cd05058   114 LASKKFVHRDLAARNCMLDESFTVKVADFGLARDIydkEYYSVHNHTGAKLPVkWMALESLQT--QKFTTKS-DVWSFGV 190
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1384865967 342 TLY-CFVYGKCPF--IDDYILTLH----RKIKneavvfpeEPEVSED-LKDLILRMLDKNPETR 397
Cdd:cd05058   191 LLWeLMTRGAPPYpdVDSFDITVYllqgRRLL--------QPEYCPDpLYEVMLSCWHPKPEMR 246
PLN03224 PLN03224
probable serine/threonine protein kinase; Provisional
256-357 6.38e-08

probable serine/threonine protein kinase; Provisional


Pssm-ID: 178763 [Multi-domain]  Cd Length: 507  Bit Score: 55.08  E-value: 6.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 256 LRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS-NQFEGNDAQLSSTAGTPAFMAPEAISdSGQSFSGKAL 334
Cdd:PLN03224  315 MRQVLTGLRKLHRIGIVHRDIKPENLLVTVDGQVKIIDFGAAvDMCTGINFNPLYGMLDPRYSPPEELV-MPQSCPRAPA 393
                          90       100
                  ....*....|....*....|...
gi 1384865967 335 DVWATGVTLYCFVYGKCPFIDDY 357
Cdd:PLN03224  394 PAMAALLSPFAWLYGRPDLFDSY 416
PTKc_EphR_B cd05065
Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze ...
199-355 6.85e-08

Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EphB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands. One exception is EphB2, which also interacts with ephrin A5. EphB receptors play important roles in synapse formation and plasticity, spine morphogenesis, axon guidance, and angiogenesis. In the intestinal epithelium, EphBs are Wnt signaling target genes that control cell compartmentalization. They function as suppressors of colon cancer progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion. The EphB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173638 [Multi-domain]  Cd Length: 269  Bit Score: 53.72  E-value: 6.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKL-------------IEVLDDPAEDNLylvfdlLRKGpvmevpcDKPFPEEQARLYLRDIILGLEY 265
Cdd:cd05065    55 EASIMGQFDHPNIIHLegvvtksrpvmiiTEFMENGALDSF------LRQN-------DGQFTVIQLVGMLRGIAAGMKY 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 266 LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGN--DAQLSSTAGTPA---FMAPEAIsdSGQSFSgKALDVWATG 340
Cdd:cd05065   122 LSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDtsDPTYTSSLGGKIpirWTAPEAI--AYRKFT-SASDVWSYG 198
                         170
                  ....*....|....*.
gi 1384865967 341 VTLY-CFVYGKCPFID 355
Cdd:cd05065   199 IVMWeVMSYGERPYWD 214
STKc_PINK1 cd14018
Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1; STKs catalyze ...
251-398 7.26e-08

Catalytic domain of the Serine/Threonine protein kinase, Pten INduced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PINK1 contains an N-terminal mitochondrial targeting sequence, a catalytic domain, and a C-terminal regulatory region. It plays an important role in maintaining mitochondrial homeostasis. It protects cells against oxidative stress-induced apoptosis by phosphorylating the chaperone TNFR-associated protein 1 (TRAP1), also called Hsp75. Phosphorylated TRAP1 prevents cytochrome c release and peroxide-induced apoptosis. PINK1 interacts with Omi/HtrA2, a serine protease, and Parkin, an E3 ubiquitin ligase, in different pathways to promote mitochondrial health. The parkin gene is the most commonly mutated gene in autosomal recessive familial parkinsonism. Mutations within the catalytic domain of PINK1 are also associated with Parkinson's disease. The PINK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270920 [Multi-domain]  Cd Length: 313  Bit Score: 54.04  E-value: 7.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 251 QARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL--GDDG--HVKIADFGVSNQFEGNDAQLS------STAGTPAFMAPE 320
Cdd:cd14018   139 LARVMILQLLEGVDHLVRHGIAHRDLKSDNILLelDFDGcpWLVIADFGCCLADDSIGLQLPfsswyvDRGGNACLMAPE 218
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 321 AISDSGQSFS----GKAlDVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDKNPET 396
Cdd:cd14018   219 VSTAVPGPGVvinySKA-DAWAVGAIAYEIFGLSNPFYGLGDTMLESRSYQESQLPALPSAVPPDVRQVVKDLLQRDPNK 297

                  ..
gi 1384865967 397 RI 398
Cdd:cd14018   298 RV 299
STKc_ACVR2b cd14140
Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the ...
262-387 7.45e-08

Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2b (or ActRIIB) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. ACVR2b is one of two ACVR2 receptors found in vertebrates. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. The ACVR2b subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271042 [Multi-domain]  Cd Length: 291  Bit Score: 53.88  E-value: 7.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLH-----CQ------KIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGND--AQLSSTAGTPAFMAPE----AISD 324
Cdd:cd14140   104 GLSYLHedvprCKgeghkpAIAHRDFKSKNVLLKNDLTAVLADFGLAVRFEPGKppGDTHGQVGTRRYMAPEvlegAINF 183
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1384865967 325 SGQSFsgKALDVWATGVTLYCFVyGKCPF----IDDYILTLHRKIKneavvfpEEPEVsEDLKDLIL 387
Cdd:cd14140   184 QRDSF--LRIDMYAMGLVLWELV-SRCKAadgpVDEYMLPFEEEIG-------QHPSL-EDLQEVVV 239
PTKc_EGFR cd05108
Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs ...
259-353 7.67e-08

Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER1, ErbB1) is a receptor PTK (RTK) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands for EGFR include EGF, heparin binding EGF-like growth factor (HBEGF), epiregulin, amphiregulin, TGFalpha, and betacellulin. Upon ligand binding, EGFR can form homo- or heterodimers with other EGFR subfamily members. The EGFR signaling pathway is one of the most important pathways regulating cell proliferation, differentiation, survival, and growth. Overexpression and mutation in the kinase domain of EGFR have been implicated in the development and progression of a variety of cancers. A number of monoclonal antibodies and small molecule inhibitors have been developed that target EGFR, including the antibodies Cetuximab and Panitumumab, which are used in combination with other therapies for the treatment of colorectal cancer and non-small cell lung carcinoma (NSCLC). The small molecule inhibitors Gefitinib (Iressa) and Erlotinib (Tarceva), already used for NSCLC, are undergoing clinical trials for other types of cancer including gastrointestinal, breast, head and neck, and bladder. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270683 [Multi-domain]  Cd Length: 313  Bit Score: 53.87  E-value: 7.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 259 IILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG-TP-AFMAPEAI---SDSGQSfsgka 333
Cdd:cd05108   118 IAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGkVPiKWMALESIlhrIYTHQS----- 192
                          90       100
                  ....*....|....*....|.
gi 1384865967 334 lDVWATGVTLY-CFVYGKCPF 353
Cdd:cd05108   193 -DVWSYGVTVWeLMTFGSKPY 212
PTKc_Wee1 cd14051
Catalytic domain of the Protein Tyrosine Kinase, Wee1; PTKs catalyze the transfer of the ...
244-407 7.87e-08

Catalytic domain of the Protein Tyrosine Kinase, Wee1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Wee1 is a nuclear cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. There are two distinct Wee1 proteins in vertebrates showing different expression patterns, called Wee1a and Wee1b. They are functionally dstinct and are implicated in different steps of egg maturation and embryo development. The Wee1 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270953 [Multi-domain]  Cd Length: 275  Bit Score: 53.56  E-value: 7.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 244 DKPFPEEQARLYLRDIILGLEYLHCQKIVHRDIKPSNLLL------------GDDGHV------------KIADFG---- 295
Cdd:cd14051    98 GERFSEAELKDLLLQVAQGLKYIHSQNLVHMDIKPGNIFIsrtpnpvsseeeEEDFEGeednpesnevtyKIGDLGhvts 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 296 VSN-QFEGNDAQlsstagtpaFMAPEaISDSGQSFSGKAlDVWATGVTLYCfVYGKCPFI---DDYiltlHRKIKNEavv 371
Cdd:cd14051   178 ISNpQVEEGDCR---------FLANE-ILQENYSHLPKA-DIFALALTVYE-AAGGGPLPkngDEW----HEIRQGN--- 238
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1384865967 372 FPEEPEVSEDLKDLILRMLDKNPETRIGVSDIKLHP 407
Cdd:cd14051   239 LPPLPQCSPEFNELLRSMIHPDPEKRPSAAALLQHP 274
STKc_PRP4 cd14135
Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze ...
253-353 9.94e-08

Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PRP4 phosphorylates a number of factors involved in the formation of active spliceosomes, which catalyze pre-mRNA splicing. It phosphorylates PRP6 and PRP31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), during spliceosomal complex formation. In fission yeast, PRP4 phosphorylates the splicing factor PRP1 (U5-102 kD in mammals). Thus, PRP4 plays a key role in regulating spliceosome assembly and pre-mRNA splicing. It also plays an important role in mitosis by acting as a spindle assembly checkpoint kinase that is required for chromosome alignment and the recruitment of the checkpoint proteins MPS1, MAD1, and MAD2 at kinetochores. The PRP4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271037 [Multi-domain]  Cd Length: 318  Bit Score: 53.77  E-value: 9.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 253 RLYLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHV-KIADFGVSNQFEGNDAqlsstagTPA-----FMAPEAIsdSG 326
Cdd:cd14135   108 RSYAQQLFLALKHLKKCNILHADIKPDNILVNEKKNTlKLCDFGSASDIGENEI-------TPYlvsrfYRAPEII--LG 178
                          90       100
                  ....*....|....*....|....*..
gi 1384865967 327 QSFSgKALDVWATGVTLYCFVYGKCPF 353
Cdd:cd14135   179 LPYD-YPIDMWSVGCTLYELYTGKILF 204
PTKc_HER2 cd05109
Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the ...
259-353 1.66e-07

Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER2 (ErbB2, HER2/neu) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER2 does not bind to any known EGFR subfamily ligands, but contributes to the kinase activity of all possible heterodimers. It acts as the preferred partner of other ligand-bound EGFR proteins and functions as a signal amplifier, with the HER2-HER3 heterodimer being the most potent pair in mitogenic signaling. HER2 plays an important role in cell development, proliferation, survival and motility. Overexpression of HER2 results in its activation and downstream signaling, even in the absence of ligand. HER2 overexpression, mainly due to gene amplification, has been shown in a variety of human cancers. Its role in breast cancer is especially well-documented. HER2 is up-regulated in about 25% of breast tumors and is associated with increases in tumor aggressiveness, recurrence and mortality. HER2 is a target for monoclonal antibodies and small molecule inhibitors, which are being developed as treatments for cancer. The first humanized antibody approved for clinical use is Trastuzumab (Herceptin), which is being used in combination with other therapies to improve the survival rates of patients with HER2-overexpressing breast cancer. The HER2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270684 [Multi-domain]  Cd Length: 279  Bit Score: 52.72  E-value: 1.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 259 IILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAG-TP-AFMAPEAISDsgQSFSGKAlDV 336
Cdd:cd05109   118 IAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGkVPiKWMALESILH--RRFTHQS-DV 194
                          90
                  ....*....|....*...
gi 1384865967 337 WATGVTLY-CFVYGKCPF 353
Cdd:cd05109   195 WSYGVTVWeLMTFGAKPY 212
PHA03207 PHA03207
serine/threonine kinase US3; Provisional
199-344 2.01e-07

serine/threonine kinase US3; Provisional


Pssm-ID: 165473 [Multi-domain]  Cd Length: 392  Bit Score: 53.31  E-value: 2.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 199 EIAILKKLDHVNVVKLIEvlddpAEDNLYLVFDLLRKgpvmeVPCD--------KPFPEEQARLYLRDIILGLEYLHCQK 270
Cdd:PHA03207  136 EIDILKTISHRAIINLIH-----AYRWKSTVCMVMPK-----YKCDlftyvdrsGPLPLEQAITIQRRLLEALAYLHGRG 205
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1384865967 271 IVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGND--AQLSSTAGTPAFMAPEAISDSgqSFSGKAlDVWATGVTLY 344
Cdd:PHA03207  206 IIHRDVKTENIFLDEPENAVLGDFGAACKLDAHPdtPQCYGWSGTLETNSPELLALD--PYCAKT-DIWSAGLVLF 278
STKc_ACVR2a cd14141
Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor; STKs catalyze the ...
255-365 2.30e-07

Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2a (or ActRIIA) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. ACVR2b is one of two ACVR2 receptors found in vertebrates. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. The ACVR2a subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271043 [Multi-domain]  Cd Length: 290  Bit Score: 52.35  E-value: 2.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 255 YLRDIILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDA--QLSSTAGTPAFMAPEAIsDSGQSFSGK 332
Cdd:cd14141   107 YLHEDIPGLKDGHKPAIAHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSagDTHGQVGTRRYMAPEVL-EGAINFQRD 185
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1384865967 333 A---LDVWATGVTLYCFVyGKCPF----IDDYILTLHRKI 365
Cdd:cd14141   186 AflrIDMYAMGLVLWELA-SRCTAsdgpVDEYMLPFEEEV 224
PKc_TESK cd14155
Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; ...
198-358 2.42e-07

Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TESK proteins phosphorylate cofilin and induce actin cytoskeletal reorganization. In the Drosphila eye, TESK is required for epithelial cell organization. Mammals contain two TESK proteins, TESK1 and TESK2, which are highly expressed in testis and play roles in spermatogenesis. TESK1 is found in testicular germ cells while TESK2 is expressed mainly in nongerminal Sertoli cells. TESK1 is stimulated by integrin-mediated signaling pathways. It regulates cell spreading and focal adhesion formation. The TESK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271057 [Multi-domain]  Cd Length: 253  Bit Score: 52.09  E-value: 2.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 198 QEIAILKKLDHVNVVKLIEVLddPAEDNLYLVFDLLRKGPVME-VPCDKPFPEEQaRLYLR-DIILGLEYLHCQKIVHRD 275
Cdd:cd14155    37 REVQLMNRLSHPNILRFMGVC--VHQGQLHALTEYINGGNLEQlLDSNEPLSWTV-RVKLAlDIARGLSYLHSKGIFHRD 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 276 IKPSNLLL--GDDGHVKI-ADFGVSNQFEGNDAQLS--STAGTPAFMAPEAIsdSGQSFSGKAlDVWATGVTLyCFVYGK 350
Cdd:cd14155   114 LTSKNCLIkrDENGYTAVvGDFGLAEKIPDYSDGKEklAVVGSPYWMAPEVL--RGEPYNEKA-DVFSYGIIL-CEIIAR 189

                  ....*...
gi 1384865967 351 CPFIDDYI 358
Cdd:cd14155   190 IQADPDYL 197
STKc_SNT7_plant cd14013
Catalytic domain of the Serine/Threonine kinase, Plant SNT7; STKs catalyze the transfer of the ...
256-409 3.31e-07

Catalytic domain of the Serine/Threonine kinase, Plant SNT7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SNT7 is a plant thylakoid-associated kinase that is essential in short- and long-term acclimation responses to cope with various light conditions in order to maintain photosynthetic redox poise for optimal photosynthetic performance. Short-term response involves state transitions over periods of minutes while the long-term response (LTR) occurs over hours to days and involves changing the relative amounts of photosystems I and II. SNT7 acts as a redox sensor and a signal transducer for both responses, which are triggered by the redox state of the plastoquinone (PQ) pool. It is positioned at the top of a phosphorylation cascade that induces state transitions by phosphorylating light-harvesting complex II (LHCII), and triggers the LTR through the phosphorylation of chloroplast proteins. The SNT7 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270915 [Multi-domain]  Cd Length: 318  Bit Score: 52.05  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 256 LRDIILGLEYLHCQKIVHRDIKPSNLLLGD-DGHVKIADFG------VSNQFEGNDAQLSstagtPAFMAPEAISDSGQS 328
Cdd:cd14013   126 MRQILVALRKLHSTGIVHRDVKPQNIIVSEgDGQFKIIDLGaaadlrIGINYIPKEFLLD-----PRYAPPEQYIMSTQT 200
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 329 FSGKAL-------------------DVWATGVTLY--CFvygkcPFI--DDYILTLHRKIKNEAVVFPE-----EPEVSE 380
Cdd:cd14013   201 PSAPPApvaaalspvlwqmnlpdrfDMYSAGVILLqmAF-----PNLrsDSNLIAFNRQLKQCDYDLNAwrmlvEPRASA 275
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1384865967 381 DLK--------------DLILRMLDKNPETRIGVSDIKLHPWV 409
Cdd:cd14013   276 DLRegfeildlddgagwDLVTKLIRYKPRGRLSASAALAHPYF 318
STKc_ACVR1_ALK1 cd14142
Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin ...
262-355 3.60e-07

Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR1, also called Activin receptor-Like Kinase 2 (ALK2), and ALK1 act as receptors for bone morphogenetic proteins (BMPs) and they activate SMAD1/5/8. ACVR1 is widely expressed while ALK1 is limited mainly to endothelial cells. The specificity of BMP binding to type I receptors is affected by type II receptors. ACVR1 binds BMP6/7/9/10 and can also bind anti-Mullerian hormone (AMH) in the presence of AMHR2. ALK1 binds BMP9/10 as well as TGFbeta in endothelial cells. A missense mutation in the GS domain of ACVR1 causes fibrodysplasia ossificans progressiva, a complex and disabling disease characterized by congenital skeletal malformations and extraskeletal bone formation. ACVR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like ACVR1 and ALK1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The ACVR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271044 [Multi-domain]  Cd Length: 298  Bit Score: 51.67  E-value: 3.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1384865967 262 GLEYLHCQ--------KIVHRDIKPSNLLLGDDGHVKIADFGVS---NQFEGN-DAQLSSTAGTPAFMAPEAISDSGQ-- 327
Cdd:cd14142   114 GLVHLHTEifgtqgkpAIAHRDLKSKNILVKSNGQCCIADLGLAvthSQETNQlDVGNNPRVGTKRYMAPEVLDETINtd 193
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1384865967 328 SF-SGKALDVWATGVTLY-----CFVYG-----KCPFID 355
Cdd:cd14142   194 CFeSYKRVDIYAFGLVLWevarrCVSGGiveeyKPPFYD 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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