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Conserved domains on  [gi|1380482440|gb|AWB91430|]
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hypothetical protein C3E78_03900 [Aeromicrobium chenweiae]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 102-344 2.87e-20

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 90.67  E-value: 2.87e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 102 RSLAAGVIWATDTLADDGLSIRNTIMRRVLRQM-------DLVWCLSHGQVPVLRSWLGVEPERIAFLPFGIDSAFYAPA 174
Cdd:cd03801   102 LLLGAPLVVTLHGAEPGRLLLLLAAERRLLARAeallrraDAVIAVSEALRDELRALGGIPPEKIVVIPNGVDLERFSPP 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 175 PW------PDRPMVLSLGN-DQDRDIPTLFSALERIRHARPDVRLV-VQTRSPLPA---------PAGVEVMPSVTTPEL 237
Cdd:cd03801   182 LRrklgipPDRPVLLFVGRlSPRKGVDLLLEALAKLLRRGPDVRLViVGGDGPLRAeleelelglGDRVRFLGFVPDEEL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 238 VSLYAAATAVVVatqPNLHVSGMTVCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDPRRAR 317
Cdd:cd03801   262 PALYAAADVFVL---PSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPELRA 338

                         250       260
                  ....*....|....*....|....*..
gi 1380482440 318 RLGRAAREHVVTHHDQSVMCRHLASLI 344
Cdd:cd03801   339 RLGRAARERVAERFSWERVAERLLDLY 365
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 102-344 2.87e-20

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 90.67  E-value: 2.87e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 102 RSLAAGVIWATDTLADDGLSIRNTIMRRVLRQM-------DLVWCLSHGQVPVLRSWLGVEPERIAFLPFGIDSAFYAPA 174
Cdd:cd03801   102 LLLGAPLVVTLHGAEPGRLLLLLAAERRLLARAeallrraDAVIAVSEALRDELRALGGIPPEKIVVIPNGVDLERFSPP 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 175 PW------PDRPMVLSLGN-DQDRDIPTLFSALERIRHARPDVRLV-VQTRSPLPA---------PAGVEVMPSVTTPEL 237
Cdd:cd03801   182 LRrklgipPDRPVLLFVGRlSPRKGVDLLLEALAKLLRRGPDVRLViVGGDGPLRAeleelelglGDRVRFLGFVPDEEL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 238 VSLYAAATAVVVatqPNLHVSGMTVCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDPRRAR 317
Cdd:cd03801   262 PALYAAADVFVL---PSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPELRA 338

                         250       260
                  ....*....|....*....|....*..
gi 1380482440 318 RLGRAAREHVVTHHDQSVMCRHLASLI 344
Cdd:cd03801   339 RLGRAARERVAERFSWERVAERLLDLY 365
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 262-346 3.07e-13

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 65.78  E-value: 3.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 262 VCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDPRRARRLGRAAREHVVTHHDQSVMCRHLA 341
Cdd:COG0438    36 VLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGEAARERAEERFSWEAIAERLL 115


                  ....*
gi 1380482440 342 SLISD 346
Cdd:COG0438   116 ALYEE 120
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 178-313 1.50e-11

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 61.91  E-value: 1.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 178 DRPMVLSLGNDQDR-DIPTLFSALERIRHARPDVRLVVQTRSP-----------LPAPAGVEVMPSVTTPELVSLYAAAT 245
Cdd:pfam00534   1 KKKIILFVGRLEPEkGLDLLIKAFALLKEKNPNLKLVIAGDGEeekrlkklaekLGLGDNVIFLGFVSDEDLPELLKIAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1380482440 246 AVVvatQPNLHVSGMTVCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDP 313
Cdd:pfam00534  81 VFV---LPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDE 145
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
262-313 1.21e-06

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 49.79  E-value: 1.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1380482440 262 VCLEAMATGRPAVLSRTPGASDYVLDGITG-HLADPGDAADHAEAVLSILDDP 313
Cdd:PRK15484  293 VAVEAMAAGKPVLASTKGGITEFVLEGITGyHLAEPMTSDSIISDINRTLADP 345
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 102-344 2.87e-20

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 90.67  E-value: 2.87e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 102 RSLAAGVIWATDTLADDGLSIRNTIMRRVLRQM-------DLVWCLSHGQVPVLRSWLGVEPERIAFLPFGIDSAFYAPA 174
Cdd:cd03801   102 LLLGAPLVVTLHGAEPGRLLLLLAAERRLLARAeallrraDAVIAVSEALRDELRALGGIPPEKIVVIPNGVDLERFSPP 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 175 PW------PDRPMVLSLGN-DQDRDIPTLFSALERIRHARPDVRLV-VQTRSPLPA---------PAGVEVMPSVTTPEL 237
Cdd:cd03801   182 LRrklgipPDRPVLLFVGRlSPRKGVDLLLEALAKLLRRGPDVRLViVGGDGPLRAeleelelglGDRVRFLGFVPDEEL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 238 VSLYAAATAVVVatqPNLHVSGMTVCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDPRRAR 317
Cdd:cd03801   262 PALYAAADVFVL---PSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGGLVVPPDDVEALADALLRLLADPELRA 338

                         250       260
                  ....*....|....*....|....*..
gi 1380482440 318 RLGRAAREHVVTHHDQSVMCRHLASLI 344
Cdd:cd03801   339 RLGRAARERVAERFSWERVAERLLDLY 365
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 115-330 5.25e-14

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 72.27  E-value: 5.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 115 LADDGLSI--RNTIMRRVLRQMDLVWCLSHGQVPVLRSWLGVEPERIAFLPFGID----------SAFYAPAPWP-DRPM 181
Cdd:cd03800   143 GAQDTYHPslRITAEEQILEAADRVIASTPQEADELISLYGADPSRINVVPPGVDlerffpvdraEARRARLLLPpDKPV 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 182 VLSLGN-DQDRDIPTLFSALERIRHARPDVRLVV---QTRSPLPAPAG--------------VEVMPSVTTPELVSLYAA 243
Cdd:cd03800   223 VLALGRlDPRKGIDTLVRAFAQLPELRELANLVLvggPSDDPLSMDREelaelaeelglidrVRFPGRVSRDDLPELYRA 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 244 ATAVVvatQPNLHVS-GMTVcLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDPRRARRLGRA 322
Cdd:cd03800   303 ADVFV---VPSLYEPfGLTA-IEAMACGTPVVATAVGGLQDIVRDGRTGLLVDPHDPEALAAALRRLLDDPALWQRLSRA 378


                  ....*...
gi 1380482440 323 AREHVVTH 330
Cdd:cd03800   379 GLERARAH 386
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 262-346 3.07e-13

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 65.78  E-value: 3.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 262 VCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDPRRARRLGRAAREHVVTHHDQSVMCRHLA 341
Cdd:COG0438    36 VLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGEAARERAEERFSWEAIAERLL 115


                  ....*
gi 1380482440 342 SLISD 346
Cdd:COG0438   116 ALYEE 120
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 152-335 4.04e-12

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 66.32  E-value: 4.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 152 LGVEPERIAFLPFGIDSAFYAPAPWPDR-PMVLSLGNDQDRD-IPTLFSALERIRHARPDVRLVVQTRSPL--------P 221
Cdd:cd05844   161 RGLPAERIHVHYIGIDPAKFAPRDPAERaPTILFVGRLVEKKgCDVLIEAFRRLAARHPTARLVIAGDGPLrpalqalaA 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 222 APAGVEVMPSVTTPELVSLYAAATAVVVATQ--PNLHVSGM-TVCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGD 298
Cdd:cd05844   241 ALGRVRFLGALPHAEVQDWMRRAEIFCLPSVtaASGDSEGLgIVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVPEGD 320

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1380482440 299 AADHAEAVLSILDDPRRARRLGRAAREHVVTHHDQSV 335
Cdd:cd05844   321 VDALADALQALLADRALADRMGGAARAFVCEQFDIRV 357
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 126-313 1.28e-11

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 65.09  E-value: 1.28e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 126 IMRRVLRQMDLVWCLSHGQVPVLRSwLGVEPERIAFLPFGIDSAFYAPAPW-----PDRPMVLSLGNDQDRD-IPTLFSA 199
Cdd:cd03798   143 LLRWALRRAARVIAVSKALAEELVA-LGVPRDRVDVIPNGVDPARFQPEDRglglpLDAFVILFVGRLIPRKgIDLLLEA 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 200 LERIRHARPDVRLVVQTRSPLPAP-----------AGVEVMPSVTTPELVSLYAAATAVVVatqPNLHVSGMTVCLEAMA 268
Cdd:cd03798   222 FARLAKARPDVVLLIVGDGPLREAlralaedlglgDRVTFTGRLPHEQVPAYYRACDVFVL---PSRHEGFGLVLLEAMA 298

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1380482440 269 TGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDP 313
Cdd:cd03798   299 CGLPVVATDVGGIPEVVGDPETGLLVPPGDADALAAALRRALAEP 343
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 178-313 1.50e-11

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 61.91  E-value: 1.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 178 DRPMVLSLGNDQDR-DIPTLFSALERIRHARPDVRLVVQTRSP-----------LPAPAGVEVMPSVTTPELVSLYAAAT 245
Cdd:pfam00534   1 KKKIILFVGRLEPEkGLDLLIKAFALLKEKNPNLKLVIAGDGEeekrlkklaekLGLGDNVIFLGFVSDEDLPELLKIAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1380482440 246 AVVvatQPNLHVSGMTVCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDP 313
Cdd:pfam00534  81 VFV---LPSRYEGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKLLEDE 145
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 126-338 1.67e-11

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 64.67  E-value: 1.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 126 IMRRVLRQMDLVWCLSHGQVPVLRSwLGVEPERIAFLPFGID--------SAFYAPAPWPDRPMVL----SLGNDQDrdI 193
Cdd:cd03794   156 LERKLYRLADAIIVLSPGLKEYLLR-KGVPKEKIIVIPNWADleefkpppKDELRKKLGLDDKFVVvyagNIGKAQG--L 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 194 PTLFSALERIRHaRPDVRLV----------VQTRSPLPAPAGVEVMPSVTTPELVSLYAAATAVVVATQPNlHVSGMTV- 262
Cdd:cd03794   233 ETLLEAAERLKR-RPDIRFLfvgdgdekerLKELAKARGLDNVTFLGRVPKEEVPELLSAADVGLVPLKDN-PANRGSSp 310

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1380482440 263 --CLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDPRRARRLGRAAREHVVTHHDQSVMCR 338
Cdd:cd03794   311 skLFEYMAAGKPILASDDGGSDLAVEINGCGLVVEPGDPEALADAILELLDDPELRRAMGENGRELAEEKFSREKLAD 388
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 126-313 8.09e-11

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 62.68  E-value: 8.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 126 IMRRVLRQMDLVWCLSHGQVPVLRSWLGVEPERIafLPFGIDSAFYAPAP----------WPDRPMVLSLGN-DQDRDIP 194
Cdd:cd03817   140 LVRRFYNHTDAVIAPSEKIKDTLREYGVKGPIEV--IPNGIDLDKFEKPLnteerrklglPPDEPILLYVGRlAKEKNID 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 195 TLFSALERIRHArPDVRLVV-----------QTRSPLPAPAGVEVMPSVTTPELVSLYAAAtavvvatqpNLHVS----- 258
Cdd:cd03817   218 FLLRAFAELKKE-PNIKLVIvgdgpereelkELARELGLADKVIFTGFVPREELPEYYKAA---------DLFVFastte 287

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1380482440 259 --GMtVCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAAdHAEAVLSILDDP 313
Cdd:cd03817   288 tqGL-VYLEAMAAGLPVVAAKDPAASELVEDGENGFLFEPNDET-LAEKLLHLRENL 342
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 122-313 1.46e-09

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 58.53  E-value: 1.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 122 IRNTIMRRVLRQMDLVWCLSH---GQvpvLRSWLGVEPERIAFLPFGIDSAFYAPAPWP--------DRPMVLSLGNDQD 190
Cdd:cd03809   127 YYRLLLPISLRRADAIITVSEatrDD---IIKFYGVPPEKIVVIPLGVDPSFFPPESAAvliakyllPEPYFLYVGTLEP 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 191 R-DIPTLFSALERIRHARPDVRLVV------------QTRSPLPAPAGVEVMPSVTTPELVSLYAAATAVVvatQPNLHV 257
Cdd:cd03809   204 RkNHERLLKAFALLKKQGGDLKLVIvggkgwedeellDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFV---FPSLYE 280

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 258 S-GMTVcLEAMATGRPAVLSRTPgasdyVLDGITG---HLADPGDAADHAEAVLSILDDP 313
Cdd:cd03809   281 GfGLPV-LEAMACGTPVIASNIS-----VLPEVAGdaaLYFDPLDPESIADAILRLLEDP 334
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 264-313 1.55e-09

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 58.76  E-value: 1.55e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1380482440 264 LEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDP 313
Cdd:cd03808   281 LEAMAAGRPVITTDVPGCRELVIDGVNGFLVPPGDVEALADAIEKLIEDP 330
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
262-312 1.72e-09

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 55.60  E-value: 1.72e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1380482440 262 VCLEAMATGRPAVLSRTPGASDyVLDGITGHLADPGDAADHAEAVLSILDD 312
Cdd:pfam13692  89 KLLEAMAAGLPVVATDVGGIPE-LVDGENGLLVPPGDPEALAEAILRLLED 138
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 104-343 2.73e-09

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 57.71  E-value: 2.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 104 LAAG--VIWatdTLADDGLSIRNTIMRRVLRQ-----MDLVWCLSHGQVPVLRSWlGVEPERIAFLPFGIDSAFYAPAPW 176
Cdd:cd03807   100 LAGGvkVIW---SVRSSNIPQRLTRLVRKLCLllskfSPATVANSSAVAEFHQEQ-GYAKNKIVVIYNGIDLFKLSPDDA 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 177 PDRPMVLSLGNDQDR-------------DIPTLFSALERIRHARPDVRLVVQTRSPLPAPAGVEVM------------PS 231
Cdd:cd03807   176 SRARARRRLGLAEDRrvigivgrlhpvkDHSDLLRAAALLVETHPDLRLLLVGRGPERPNLERLLLelgledrvhllgER 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 232 VTTPELVS-LYAAATAVVVATQPNlhvsgmtVCLEAMATGRPAVLSRTPGASDYVLDGiTGHLADPGDAADHAEAVLSIL 310
Cdd:cd03807   256 SDVPALLPaMDIFVLSSRTEGFPN-------ALLEAMACGLPVVATDVGGAAELVDDG-TGFLVPAGDPQALADAIRALL 327

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1380482440 311 DDPRRARRLGRAAREHVVTHHDQSVMCRHLASL 343
Cdd:cd03807   328 EDPEKRARLGRAARERIANEFSIDAMVRRYETL 360
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 126-313 8.99e-09

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 56.15  E-value: 8.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 126 IMRRVLRQMDLVWCLSHGQVPVLRSWlgvEPERIAFLPFGIDSAFYAPAP----------WPDRPMVLSLGN-DQDRDIP 194
Cdd:cd03814   138 YLRWFHNPFDTTLVPSPSIARELEGH---GFERVRLWPRGVDTELFHPSRrdaalrrrlgPPGRPLLLYVGRlAPEKNLE 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 195 TLFSALERIRhARPDVRLVV----------QTRSP----LPAPAGVE-----------VMPSVTtpELVSLyaaatavvv 249
Cdd:cd03814   215 ALLDADLPLA-ASPPVRLVVvgdgparaelEARGPdvifTGFLTGEElarayasadvfVFPSRT--ETFGL--------- 282

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1380482440 250 atqpnlhvsgmtVCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDP 313
Cdd:cd03814   283 ------------VVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEPGDAAAFAAALRALLEDP 334
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 158-336 2.60e-08

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 55.03  E-value: 2.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 158 RIAFLPFGIDSAFYAPAPWP----------DRPMVLSLGNDQD---RDIPTLFSALERIrHARPDVRLVVQTRSPLP-AP 223
Cdd:cd03825   162 PVVVIPNGIDTEIFAPVDKAkarkrlgipqDKKVILFGAESVTkprKGFDELIEALKLL-ATKDDLLLVVFGKNDPQiVI 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 224 AGVEVMP-SVTTPE--LVSLYAAATA-VVVATQPNLhvsGMTVClEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDA 299
Cdd:cd03825   241 LPFDIISlGYIDDDeqLVDIYSAADLfVHPSLADNL---PNTLL-EAMACGTPVVAFDTGGSPEIVQHGVTGYLVPPGDV 316

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1380482440 300 ADHAEAVLSILDDPRRARRLGRAAREHVVTHHDQSVM 336
Cdd:cd03825   317 QALAEAIEWLLANPKERESLGERARALAENHFDQRVQ 353
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 262-313 9.01e-08

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 53.12  E-value: 9.01e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1380482440 262 VCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDP 313
Cdd:cd04962   285 AALEAMACGVPVVSSNAGGIPEVVKHGETGFLSDVGDVDAMAKSALSILEDD 336
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 117-341 1.34e-07

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 52.75  E-value: 1.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 117 DDGLSIRNTIMRRVLRQMDLVWCLSHGQV----PVLRSWLGVEPERIAFLPFGIDSAFYAPAPW-----PDRPMVLSLGN 187
Cdd:cd03818   142 RCRLRNRNIALLLSLEQADLGVTPTRWQRslfpAAYRDRISVIHDGVDTDRLAPDPAARLRLLNgtelkAGDPVITYVAR 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 188 DQD--RDIPTLFSALERIRHARPDVRLV------VQTRSPLPAPAG---------------VEVMPSVTTPELVSLYAAA 244
Cdd:cd03818   222 NLEpyRGFHVFMRALPRIQARRPDARVVvvggdgVSYGSPPPDGGSwkqkmlaelgvdlerVHFVGKVPYDQYVRLLQLS 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 245 TAVVVATQPNLHVSGMtvcLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDPRRARRLGRAAR 324
Cdd:cd03818   302 DAHVYLTYPFVLSWSL---LEAMACGCPVIGSDTAPVREVIRDGRNGLLVDFFDPDALAAAVLELLEDPDRAAALRRAAR 378

                         250
                  ....*....|....*...
gi 1380482440 325 EHVVTHHD-QSVMCRHLA 341
Cdd:cd03818   379 RTVERSDSlDVCLARYLA 396
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 123-313 2.91e-07

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 51.60  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 123 RNTIMRRVLRQMDLVWCLSHGQVPVLRsWLGVEPeRIAFLPFGIDSAFYAPAPW--------PDRPMVLSLGN-DQDRDI 193
Cdd:cd03821   142 LHLIERRNLNNAALVHFTSEQEADELR-RFGLEP-PIAVIPNGVDIPEFDPGLRdrrkhnglEDRRIILFLGRiHPKKGL 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 194 PTLFSALERIRHARPDVRLVV--------QTRSPLPAPAGVE---VMPSVTTPE--LVSLYAAATAVVVATQPNLhvsGM 260
Cdd:cd03821   220 DLLIRAARKLAEQGRDWHLVIagpddgayPAFLQLQSSLGLGdrvTFTGPLYGEakWALYASADLFVLPSYSENF---GN 296

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1380482440 261 TVcLEAMATGRPAVLSRTPGASDYVLDGItGHLADPgDAADHAEAVLSILDDP 313
Cdd:cd03821   297 VV-AEALACGLPVVITDKCGLSELVEAGC-GVVVDP-NVSSLAEALAEALRDP 346
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
262-313 1.21e-06

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 49.79  E-value: 1.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1380482440 262 VCLEAMATGRPAVLSRTPGASDYVLDGITG-HLADPGDAADHAEAVLSILDDP 313
Cdd:PRK15484  293 VAVEAMAAGKPVLASTKGGITEFVLEGITGyHLAEPMTSDSIISDINRTLADP 345
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 262-313 6.21e-06

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 47.65  E-value: 6.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1380482440 262 VCLEAMATGRPAVLSRTPGASDYV-LDGITGHLADPGDAADHAEAVLSILDDP 313
Cdd:cd03795   279 VLLEAMMCGKPVISTNIGTGVPYVnNNGETGLVVPPKDPDALAEAIDKLLSDE 331
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 132-313 2.47e-05

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 45.79  E-value: 2.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 132 RQMDLVWCLSHGQvpvlRSW---LGVEPERIAFLPFGIDSAFYAPA----PWPDRPMVLSLGN-DQDRDIPTLFSALERI 203
Cdd:cd03813   243 QQADKIISLYEGN----RRRqirLGADPDKTRVIPNGIDIQRFAPAreerPEKEPPVVGLVGRvVPIKDVKTFIRAFKLV 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 204 RHARPDVRLVV---QTRSPLPAPAGVEVMPSVTTPELVSLYAAATAVVVATQPNLHV-----SGM-TVCLEAMATGRPAV 274
Cdd:cd03813   319 RRAMPDAEGWLigpEDEDPEYAQECKRLVASLGLENKVKFLGFQNIKEYYPKLGLLVltsisEGQpLVILEAMASGVPVV 398

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1380482440 275 LSRTPGASDYVLD-----GITGHLADPGDAADHAEAVLSILDDP 313
Cdd:cd03813   399 ATDVGSCRELIYGaddalGQAGLVVPPADPEALAEALIKLLRDP 442
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 128-313 8.20e-05

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 43.89  E-value: 8.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 128 RRVLRQMDLVWCLSHGQVPVLRSWLGVEPERIAFLPFGID---SAFYAPAPW----PDRPMVLSLGN-DQDRDIPTLFSA 199
Cdd:cd03811   130 LKLYKKADKIVCVSKGIKEDLIRLGPSPPEKIEVIYNPIDidrIRALAKEPIlnepEDGPVILAVGRlDPQKGHDLLIEA 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 200 LERIRHARPDVRLV--------------VQT-----------RSPLPAP----AGVEVMPSVTTPelvslyaaatavvva 250
Cdd:cd03811   210 FAKLRKKYPDVKLVilgdgplreeleklAKElglaerviflgFQSNPYPylkkADLFVLSSRYEG--------------- 274

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1380482440 251 tQPNlhvsgmtVCLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDP 313
Cdd:cd03811   275 -FPN-------VLLEAMALGTPVVSTDCPGPREILDDGENGLLVPDGDAAALAGILAALLQKK 329
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 262-313 1.45e-04

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 43.55  E-value: 1.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1380482440 262 VCLEAMATGRPAVLSRTPGASDYV---LDGITGHLADPGDAADHAEAVLSILDDP 313
Cdd:PLN02871  347 VVLEAMASGVPVVAARAGGIPDIIppdQEGKTGFLYTPGDVDDCVEKLETLLADP 401
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 152-313 2.22e-04

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 42.73  E-value: 2.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 152 LGVEPERIAFLPFGIDSAFYAPAPWP----------DRPMVLSLGN-DQDRDIPTLFSALERIRHaRPDVRLVVQTRSPL 220
Cdd:cd03819   145 LGVDPERIRVIPNGVDTDRFPPEAEAeeraqlglpeGKPVVGYVGRlSPEKGWLLLVDAAAELKD-EPDFRLLVAGDGPE 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 221 PApagvEVMPSVTTPEL---VSLYAAATAVVVATQ-------PNLHVSGMTVCLEAMATGRPAVLSRTPGASDYVLDGIT 290
Cdd:cd03819   224 RD----EIRRLVERLGLrdrVTFTGFREDVPAALAasdvvvlPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRT 299

                         170       180
                  ....*....|....*....|...
gi 1380482440 291 GHLADPGDAADHAEAVLSILDDP 313
Cdd:cd03819   300 GLLVPPGDAEALADAIRAAKLLP 322
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 206-313 3.42e-04

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 41.93  E-value: 3.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 206 ARPDVRLVVQTRSPL------PAPAGVEVMPSVTTPELVSLYAaatavvvatqpNLHV----------SGMTVcLEAMAT 269
Cdd:cd03823   217 PREDIELVIAGHGPLsderqiEGGRRIAFLGRVPTDDIKDFYE-----------KIDVlvvpsiwpepFGLVV-REAIAA 284

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1380482440 270 GRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDP 313
Cdd:cd03823   285 GLPVIASDLGGIAELIQPGVNGLLFAPGDAEDLAAAMRRLLTDP 328
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 259-313 1.04e-03

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 40.36  E-value: 1.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1380482440 259 GMTVcLEAMATGRPAVLSRTP-GASDYVLDGITGHLADPGDAADHAEAVLSILDDP 313
Cdd:cd04949   248 GLTL-MEAIGHGLPVVSYDVKyGPSELIEDGENGYLIEKNNIDALADKIIELLNDP 302
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 265-340 1.17e-03

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 40.51  E-value: 1.17e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1380482440 265 EAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAADHAEAVLSILDDPRRARRLGRAAREHVVTHHDQSVMCRHL 340
Cdd:cd03799   275 EAMAMGLPVISTEHGGIPELVEDGVSGFLVPERDAEAIAEKLTYLIEHPAIWPEMGKAGRARVEEEYDINKLNDEL 350
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 259-330 5.89e-03

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 38.07  E-value: 5.89e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1380482440 259 GMTVcLEAMATGRPAVLSRTPGASDYVLDGITGHLADPGDAAdhAEAVLSILDDPRRARRLGRAAREHVVTH 330
Cdd:cd03792   293 GLTV-SEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGA--AVRILRLLTDPELRRKMGLAAREHVRDN 361
COG4641 COG4641
Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];
108-331 8.96e-03

Spore maturation protein CgeB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443679 [Multi-domain]  Cd Length: 303  Bit Score: 37.60  E-value: 8.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 108 VIWATDTLAddglsiRNTIMRRVLRQMDLVWCLSHGQVPVLRSWlGVEpeRIAFLPFGIDSAFYAPAPWPDRPM--VLSL 185
Cdd:COG4641    73 VFWDTDDPV------TLDRFRELLPLYDLVFTFDGDCVEEYRAL-GAR--RVFYLPFAADPELHRPVPPEARFRydVAFV 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1380482440 186 GN-DQDRdiptlFSALERIRHARPDVRLVVQTR--SPLPAPAGVEVMPSVTTPELVSLYAAATAvvvatqpNLHVSGMTV 262
Cdd:COG4641   144 GNyYPDR-----RARLEELLLAPAGLRLKIYGPgwPKLALPANVRRGGHLPGEEHPAAYASSKI-------TLNVNRMAA 211

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1380482440 263 C--------LEAMATGRPAVLSRTPGASDYVLDGITGHLADpgDAADHAEAVLSILDDPRRARRLGRAAREHVVTHH 331
Cdd:COG4641   212 SpdsptrrtFEAAACGAFLLSDPWEGLEELFEPGEEVLVFR--DGEELAEKLRYLLADPEERRAIAEAGRRRVLAEH 286
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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