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Conserved domains on  [gi|1379741803|ref|XP_024628045|]
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WD repeat-containing protein 44 isoform X2 [Medicago truncatula]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-431 1.61e-34

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 1.61e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 158 QEIRAHKGLIWTMKFSPNGQYLASGGEDGVVRIWRVFSRNkshppfvslpndifqieesPLQELFGHSSDILDLAWS-NS 236
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-------------------LLRTLTGHSGAVTSVAFSpDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 237 DILLSSSMDKTVRAWKISCDQCLSVFP-HKGFVTCIQFNPvNENYFISGSIDGKVRIWGIREERVID-WADIRDVISAIS 314
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtLTGHSGSVRSVA 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 315 YQQDGKGFVVGSLTGTCRFY-VASGKyfqlegqidIPGKKKASGNKITGIQFFQNNcQRIMITSEDSKICI--LDQTEIV 391
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWdLATGE---------LLRTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRLwdLATGKLL 323

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1379741803 392 QKYKGlpWSGSQMSGSFTSSGKHIISVGEDSHVYIWNFND 431
Cdd:COG2319   324 RTLTG--HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-431 1.61e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 1.61e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 158 QEIRAHKGLIWTMKFSPNGQYLASGGEDGVVRIWRVFSRNkshppfvslpndifqieesPLQELFGHSSDILDLAWS-NS 236
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-------------------LLRTLTGHSGAVTSVAFSpDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 237 DILLSSSMDKTVRAWKISCDQCLSVFP-HKGFVTCIQFNPvNENYFISGSIDGKVRIWGIREERVID-WADIRDVISAIS 314
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtLTGHSGSVRSVA 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 315 YQQDGKGFVVGSLTGTCRFY-VASGKyfqlegqidIPGKKKASGNKITGIQFFQNNcQRIMITSEDSKICI--LDQTEIV 391
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWdLATGE---------LLRTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRLwdLATGKLL 323

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1379741803 392 QKYKGlpWSGSQMSGSFTSSGKHIISVGEDSHVYIWNFND 431
Cdd:COG2319   324 RTLTG--HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 158-428 8.14e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 8.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 158 QEIRAHKGLIWTMKFSPNGQYLASGGEDGVVRIWRV-----FSRNKSHPPFV----SLPND-------------IFQIE- 214
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLetgelLRTLKGHTGPVrdvaASADGtylasgssdktirLWDLEt 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 215 ESPLQELFGHSSDILDLAWSNSD-ILLSSSMDKTVRAWKISCDQCLSVFP-HKGFVTCIQFNPVNeNYFISGSIDGKVRI 292
Cdd:cd00200    83 GECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDG-TFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 293 WGIREERVIdwADIR---DVISAISYQQDGKGFVVGSLTGTCRFYVASGkyFQLEGQIdipgkkKASGNKITGIQFFQNN 369
Cdd:cd00200   162 WDLRTGKCV--ATLTghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST--GKCLGTL------RGHENGVNSVAFSPDG 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1379741803 370 cqRIMIT-SEDSKICI--LDQTEIVQKYKGLPWSGSQMSgsFTSSGKHIISVGEDSHVYIWN 428
Cdd:cd00200   232 --YLLASgSEDGTIRVwdLRTGECVQTLSGHTNSVTSLA--WSPDGKRLASGSADGTIRIWD 289
PTZ00420 PTZ00420
coronin; Provisional
 212-331 9.71e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.04  E-value: 9.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 212 QIEESPLQELFGHSSDILDLAWSN--SDILLSSSMDKTVRAWKISCD----------QCLsVFPHKGFVTCIQFNPVNen 279
Cdd:PTZ00420   61 QMRKPPVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHNdesvkeikdpQCI-LKGHKKKISIIDWNPMN-- 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1379741803 280 YFI--SGSIDGKVRIWGIREERVIDWADIRDVISaiSYQQDGKGFVvgsLTGTC 331
Cdd:PTZ00420  138 YYImcSSGFDSFVNIWDIENEKRAFQINMPKKLS--SLKWNIKGNL---LSGTC 186
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 158-191 8.04e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 8.04e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1379741803  158 QEIRAHKGLIWTMKFSPNGQYLASGGEDGVVRIW 191
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
158-191 5.85e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 5.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1379741803 158 QEIRAHKGLIWTMKFSPNGQYLASGGEDGVVRIW 191
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-431 1.61e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 1.61e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 158 QEIRAHKGLIWTMKFSPNGQYLASGGEDGVVRIWRVFSRNkshppfvslpndifqieesPLQELFGHSSDILDLAWS-NS 236
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-------------------LLRTLTGHSGAVTSVAFSpDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 237 DILLSSSMDKTVRAWKISCDQCLSVFP-HKGFVTCIQFNPvNENYFISGSIDGKVRIWGIREERVID-WADIRDVISAIS 314
Cdd:COG2319   175 KLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtLTGHSGSVRSVA 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 315 YQQDGKGFVVGSLTGTCRFY-VASGKyfqlegqidIPGKKKASGNKITGIQFFQNNcQRIMITSEDSKICI--LDQTEIV 391
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWdLATGE---------LLRTLTGHSGGVNSVAFSPDG-KLLASGSDDGTVRLwdLATGKLL 323

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1379741803 392 QKYKGlpWSGSQMSGSFTSSGKHIISVGEDSHVYIWNFND 431
Cdd:COG2319   324 RTLTG--HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
158-431 3.40e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.19  E-value: 3.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 158 QEIRAHKGLIWTMKFSPNGQYLASGGEDGVVRIWRVFSRNkshppfvslpndifqieesPLQELFGHSSDILDLAWS-NS 236
Cdd:COG2319   156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-------------------LLRTLTGHTGAVRSVAFSpDG 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 237 DILLSSSMDKTVRAWKISCDQCLSVFP-HKGFVTCIQFNPvNENYFISGSIDGKVRIWGIREERVID-WADIRDVISAIS 314
Cdd:COG2319   217 KLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRtLTGHSGGVNSVA 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 315 YQQDGKGFVVGSLTGTCRFY-VASGKYFQ-LEGQIDipgkkkasgnKITGIQFFQNNcQRIMITSEDSKICI--LDQTEI 390
Cdd:COG2319   296 FSPDGKLLASGSDDGTVRLWdLATGKLLRtLTGHTG----------AVRSVAFSPDG-KTLASGSDDGTVRLwdLATGEL 364

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1379741803 391 VQKYKGLpwSGSQMSGSFTSSGKHIISVGEDSHVYIWNFND 431
Cdd:COG2319   365 LRTLTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 158-428 8.14e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 8.14e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 158 QEIRAHKGLIWTMKFSPNGQYLASGGEDGVVRIWRV-----FSRNKSHPPFV----SLPND-------------IFQIE- 214
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLetgelLRTLKGHTGPVrdvaASADGtylasgssdktirLWDLEt 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 215 ESPLQELFGHSSDILDLAWSNSD-ILLSSSMDKTVRAWKISCDQCLSVFP-HKGFVTCIQFNPVNeNYFISGSIDGKVRI 292
Cdd:cd00200    83 GECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDG-TFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 293 WGIREERVIdwADIR---DVISAISYQQDGKGFVVGSLTGTCRFYVASGkyFQLEGQIdipgkkKASGNKITGIQFFQNN 369
Cdd:cd00200   162 WDLRTGKCV--ATLTghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST--GKCLGTL------RGHENGVNSVAFSPDG 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1379741803 370 cqRIMIT-SEDSKICI--LDQTEIVQKYKGLPWSGSQMSgsFTSSGKHIISVGEDSHVYIWN 428
Cdd:cd00200   232 --YLLASgSEDGTIRVwdLRTGECVQTLSGHTNSVTSLA--WSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 217-428 1.73e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 1.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 217 PLQELFGHSSDILDLAWS-NSDILLSSSMDKTVRAWKISCDQCLSVFP-HKGFVTCIQFNPvNENYFISGSIDGKVRIWG 294
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-DGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 295 IR-EERVIDWADIRDVISAISYQQDGKGFVVGSLTGTCRFY-VASGKYFQ-LEGQ------IDIPGKKK----ASGNK-- 359
Cdd:cd00200    80 LEtGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdVETGKCLTtLRGHtdwvnsVAFSPDGTfvasSSQDGti 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 360 --------------------ITGIQFFQNNcQRIMITSEDSKICILDQTEIVQKYKGLPWSGSQMSGSFTSSGKHIISVG 419
Cdd:cd00200   160 klwdlrtgkcvatltghtgeVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGS 238


                  ....*....
gi 1379741803 420 EDSHVYIWN 428
Cdd:cd00200   239 EDGTIRVWD 247
PTZ00420 PTZ00420
coronin; Provisional
 212-331 9.71e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.04  E-value: 9.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 212 QIEESPLQELFGHSSDILDLAWSN--SDILLSSSMDKTVRAWKISCD----------QCLsVFPHKGFVTCIQFNPVNen 279
Cdd:PTZ00420   61 QMRKPPVIKLKGHTSSILDLQFNPcfSEILASGSEDLTIRVWEIPHNdesvkeikdpQCI-LKGHKKKISIIDWNPMN-- 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1379741803 280 YFI--SGSIDGKVRIWGIREERVIDWADIRDVISaiSYQQDGKGFVvgsLTGTC 331
Cdd:PTZ00420  138 YYImcSSGFDSFVNIWDIENEKRAFQINMPKKLS--SLKWNIKGNL---LSGTC 186
WD40 COG2319
WD40 repeat [General function prediction only];
215-428 5.79e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 5.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 215 ESPLQELFGHSSDILDLAWS-NSDILLSSSMDKTVRAWKISCDQCLSVFP-HKGFVTCIQFNPvNENYFISGSIDGKVRI 292
Cdd:COG2319    26 GALLLLLLGLAAAVASLAASpDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAAVLSVAFSP-DGRLLASASADGTVRL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 293 WGIR-EERVIDWADIRDVISAISYQQDGKGFVVGSLTGTCRFY-VASGKYFQ-LEGQidipgkkkasGNKITGIQFFQNN 369
Cdd:COG2319   105 WDLAtGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWdLATGKLLRtLTGH----------SGAVTSVAFSPDG 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1379741803 370 cQRIMITSEDSKICI--LDQTEIVQKYKGlpWSGSQMSGSFTSSGKHIISVGEDSHVYIWN 428
Cdd:COG2319   175 -KLLASGSDDGTVRLwdLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 158-191 8.04e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 8.04e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1379741803  158 QEIRAHKGLIWTMKFSPNGQYLASGGEDGVVRIW 191
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
158-191 5.85e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 5.85e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1379741803 158 QEIRAHKGLIWTMKFSPNGQYLASGGEDGVVRIW 191
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 257-293 3.50e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.50e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1379741803  257 QCLSVFP-HKGFVTCIQFNPvNENYFISGSIDGKVRIW 293
Cdd:smart00320   3 ELLKTLKgHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 158-247 7.95e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 48.14  E-value: 7.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 158 QEIRAHKGLIWTMKFSPNGQYLASGGEDGVVRIWRVF----SRNKSHPPFVSLPNDIFQIEESPLQELFGHSSDILDLAW 233
Cdd:pfam20426 118 QSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLrgrsSEKRSRNTQTEFPRKDHVIAETPFHILCGHDDIITCLYV 197

                          90
                  ....*....|....*
gi 1379741803 234 SNS-DILLSSSMDKT 247
Cdd:pfam20426 198 SVElDIVISGSKDGT 212
WD40 pfam00400
WD domain, G-beta repeat;
257-293 1.90e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1379741803 257 QCLSVFP-HKGFVTCIQFNPvNENYFISGSIDGKVRIW 293
Cdd:pfam00400   2 KLLKTLEgHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 159-254 2.55e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 2.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 159 EIRAHKGLIWTMKFSP-NGQYLASGGEDGVVRIWRVFS-------RNKSHPPFVSLPNDI-----------------FQI 213
Cdd:PLN00181  570 EMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQgvsigtiKTKANICCVQFPSESgrslafgsadhkvyyydLRN 649

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1379741803 214 EESPLQELFGHSSDILDLAWSNSDILLSSSMDKTVRAWKIS 254
Cdd:PLN00181  650 PKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 216-252 1.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.06e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1379741803  216 SPLQELFGHSSDILDLAWS-NSDILLSSSMDKTVRAWK 252
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSpDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
216-251 1.29e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.29e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1379741803 216 SPLQELFGHSSDILDLAWS-NSDILLSSSMDKTVRAW 251
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSpDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 159-253 1.34e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.47  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379741803 159 EIRAHKGLIWTMKFSP-NGQYLASGGEDGVVRIWRVFSRNKShppfvslPNDIfqieESPLQELFGHSSDILDLAWS--N 235
Cdd:PTZ00420   69 KLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDES-------VKEI----KDPQCILKGHKKKISIIDWNpmN 137

                          90
                  ....*....|....*...
gi 1379741803 236 SDILLSSSMDKTVRAWKI 253
Cdd:PTZ00420  138 YYIMCSSGFDSFVNIWDI 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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