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Conserved domains on  [gi|1379641851|ref|XP_024640826|]
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receptor-like protein Cf-9 [Medicago truncatula]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000136)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 44-550 7.64e-53

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 193.91  E-value: 7.64e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851  44 PLLKTATWKNGTDCCSWNGVTCdTVSGHVIDLNLGCEGLTGTFnpNSTLFHLVHLQTLNLSYNDFFDSHFHYKFCGFQSL 123
Cdd:PLN00113   44 PLKYLSNWNSSADVCLWQGITC-NNSSRVVSIDLSGKNISGKI--SSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 124 THLDLSDSNLEGEIPTqiSHLSKLQSLHLSEN------YDLIWKETTLKRL--------------LQNATDLRELFLDST 183
Cdd:PLN00113  121 RYLNLSNNNFTGSIPR--GSIPNLETLDLSNNmlsgeiPNDIGSFSSLKVLdlggnvlvgkipnsLTNLTSLEFLTLASN 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 184 DMSSIRPNSiallLNQSLSLVTLNLHYTRLSGKLKRSLICLASIQELDMSYNDeLQGQLP-ELSCSTSLRIIDLSGCAFE 262
Cdd:PLN00113  199 QLVGQIPRE----LGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNN-LTGPIPsSLGNLKNLQYLFLYQNKLS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 263 GEIPMYFSNLTHLTSLTLSNNNLNGSIPSSLLTLPRLTFLHLYSNQLSGRIPNA--SLPNLQ------------------ 322
Cdd:PLN00113  274 GPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVAltSLPRLQvlqlwsnkfsgeipknlg 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 323 ---HLIHLDLSKNLFSGQIPSSLFNLNQLYTLDCSKNKLEGPIPNKTTGFQELNDLRLNDNLLNGTIPSSLLSLPSLVHL 399
Cdd:PLN00113  354 khnNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFL 433

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 400 VLSNNRLTRHITAIS--SYSLKKLDLSGNKLQGNIPKSiFNLANLTLLDLSSNNLSDVIDfQHFSKLQYLKTLSLSHNsq 477
Cdd:PLN00113  434 DISNNNLQGRINSRKwdMPSLQMLSLARNKFFGGLPDS-FGSKRLENLDLSRNQFSGAVP-RKLGSLSELMQLKLSEN-- 509

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1379641851 478 lSLTFE-PNVNYNFSYLSKLDLSSINLT-EFPIS-GKVPLLDSLDLSNNKLNGKVPDWLPEtMNSLTFLNLSQNMF 550
Cdd:PLN00113  510 -KLSGEiPDELSSCKKLVSLDLSHNQLSgQIPASfSEMPVLSQLDLSQNQLSGEIPKNLGN-VESLVQVNISHNHL 583
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 44-550 7.64e-53

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 193.91  E-value: 7.64e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851  44 PLLKTATWKNGTDCCSWNGVTCdTVSGHVIDLNLGCEGLTGTFnpNSTLFHLVHLQTLNLSYNDFFDSHFHYKFCGFQSL 123
Cdd:PLN00113   44 PLKYLSNWNSSADVCLWQGITC-NNSSRVVSIDLSGKNISGKI--SSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 124 THLDLSDSNLEGEIPTqiSHLSKLQSLHLSEN------YDLIWKETTLKRL--------------LQNATDLRELFLDST 183
Cdd:PLN00113  121 RYLNLSNNNFTGSIPR--GSIPNLETLDLSNNmlsgeiPNDIGSFSSLKVLdlggnvlvgkipnsLTNLTSLEFLTLASN 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 184 DMSSIRPNSiallLNQSLSLVTLNLHYTRLSGKLKRSLICLASIQELDMSYNDeLQGQLP-ELSCSTSLRIIDLSGCAFE 262
Cdd:PLN00113  199 QLVGQIPRE----LGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNN-LTGPIPsSLGNLKNLQYLFLYQNKLS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 263 GEIPMYFSNLTHLTSLTLSNNNLNGSIPSSLLTLPRLTFLHLYSNQLSGRIPNA--SLPNLQ------------------ 322
Cdd:PLN00113  274 GPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVAltSLPRLQvlqlwsnkfsgeipknlg 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 323 ---HLIHLDLSKNLFSGQIPSSLFNLNQLYTLDCSKNKLEGPIPNKTTGFQELNDLRLNDNLLNGTIPSSLLSLPSLVHL 399
Cdd:PLN00113  354 khnNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFL 433

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 400 VLSNNRLTRHITAIS--SYSLKKLDLSGNKLQGNIPKSiFNLANLTLLDLSSNNLSDVIDfQHFSKLQYLKTLSLSHNsq 477
Cdd:PLN00113  434 DISNNNLQGRINSRKwdMPSLQMLSLARNKFFGGLPDS-FGSKRLENLDLSRNQFSGAVP-RKLGSLSELMQLKLSEN-- 509

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1379641851 478 lSLTFE-PNVNYNFSYLSKLDLSSINLT-EFPIS-GKVPLLDSLDLSNNKLNGKVPDWLPEtMNSLTFLNLSQNMF 550
Cdd:PLN00113  510 -KLSGEiPDELSSCKKLVSLDLSHNQLSgQIPASfSEMPVLSQLDLSQNQLSGEIPKNLGN-VESLVQVNISHNHL 583
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
132-563 8.45e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 8.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 132 NLEGEIPTQISHLSKLQSLHLSENYDLIWKETTLKRLLQNATDLRELFLDSTDMSSIRPNSIALLLNQSLSLVTLNLHYT 211
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 212 RLSGKLKRSLIC-LASIQELDMSYNDELQGqlpelscSTSLRIIDLSGCAFEgEIPMYFSNLTHLTSLTLSNNNLNgSIP 290
Cdd:COG4886    82 LSLLLLGLTDLGdLTNLTELDLSGNEELSN-------LTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 291 SSLLTLPRLTFLHLYSNQLSGrIPnASLPNLQHLIHLDLSKNLFSgQIPSSLFNLNQLYTLDCSKNKLEgPIPNKTTGFQ 370
Cdd:COG4886   153 EPLGNLTNLKSLDLSNNQLTD-LP-EELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLT 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 371 ELNDLRLNDNLLngtipssllslpslvhlvlsnnrltRHITAISS-YSLKKLDLSGNKLQgNIPKSiFNLANLTLLDLSS 449
Cdd:COG4886   229 NLETLDLSNNQL-------------------------TDLPELGNlTNLEELDLSNNQLT-DLPPL-ANLTNLKTLDLSN 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 450 NNLSDVIDFQHFSKLQYLKTLSLSHNSQLSLTFEPNVNYNFSYLSKLDLSSINLTEFPISGKVPLLDSLDLSNNKLNGKV 529
Cdd:COG4886   282 NQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1379641851 530 PDWLPETMNSLTFLNLSQNMFTSIDQISMKNEQL 563
Cdd:COG4886   362 LLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 272-475 2.58e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.35  E-value: 2.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 272 LTHLTSLTLSNNNLNgSIPSsLLTLPRLTFLHLYSNQLSgRIPNasLPNLQHLIHLDLSKNlfsgQIPS--SLFNLNQLY 349
Cdd:cd21340     1 LKRITHLYLNDKNIT-KIDN-LSLCKNLKVLYLYDNKIT-KIEN--LEFLTNLTHLYLQNN----QIEKieNLENLVNLK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 350 TLDCSKNKLEgpipnKTTGFQELNDLRlndnllngtipssllslpslvHLVLSNNRL---------TRHITAIsSYSLKK 420
Cdd:cd21340    72 KLYLGGNRIS-----VVEGLENLTNLE---------------------ELHIENQRLppgekltfdPRSLAAL-SNSLRV 124

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1379641851 421 LDLSGNKLQgnIPKSIFNLANLTLLDLSSNNLSDVIDFQH-FSKLQYLKTLSLSHN 475
Cdd:cd21340   125 LNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
417-475 5.24e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.24e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1379641851 417 SLKKLDLSGNKLQGNIPKSIFNLANLTLLDLSSNNLSdVIDFQHFSKLQYLKTLSLSHN 475
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 44-550 7.64e-53

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 193.91  E-value: 7.64e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851  44 PLLKTATWKNGTDCCSWNGVTCdTVSGHVIDLNLGCEGLTGTFnpNSTLFHLVHLQTLNLSYNDFFDSHFHYKFCGFQSL 123
Cdd:PLN00113   44 PLKYLSNWNSSADVCLWQGITC-NNSSRVVSIDLSGKNISGKI--SSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 124 THLDLSDSNLEGEIPTqiSHLSKLQSLHLSEN------YDLIWKETTLKRL--------------LQNATDLRELFLDST 183
Cdd:PLN00113  121 RYLNLSNNNFTGSIPR--GSIPNLETLDLSNNmlsgeiPNDIGSFSSLKVLdlggnvlvgkipnsLTNLTSLEFLTLASN 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 184 DMSSIRPNSiallLNQSLSLVTLNLHYTRLSGKLKRSLICLASIQELDMSYNDeLQGQLP-ELSCSTSLRIIDLSGCAFE 262
Cdd:PLN00113  199 QLVGQIPRE----LGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNN-LTGPIPsSLGNLKNLQYLFLYQNKLS 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 263 GEIPMYFSNLTHLTSLTLSNNNLNGSIPSSLLTLPRLTFLHLYSNQLSGRIPNA--SLPNLQ------------------ 322
Cdd:PLN00113  274 GPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVAltSLPRLQvlqlwsnkfsgeipknlg 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 323 ---HLIHLDLSKNLFSGQIPSSLFNLNQLYTLDCSKNKLEGPIPNKTTGFQELNDLRLNDNLLNGTIPSSLLSLPSLVHL 399
Cdd:PLN00113  354 khnNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFL 433

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 400 VLSNNRLTRHITAIS--SYSLKKLDLSGNKLQGNIPKSiFNLANLTLLDLSSNNLSDVIDfQHFSKLQYLKTLSLSHNsq 477
Cdd:PLN00113  434 DISNNNLQGRINSRKwdMPSLQMLSLARNKFFGGLPDS-FGSKRLENLDLSRNQFSGAVP-RKLGSLSELMQLKLSEN-- 509

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1379641851 478 lSLTFE-PNVNYNFSYLSKLDLSSINLT-EFPIS-GKVPLLDSLDLSNNKLNGKVPDWLPEtMNSLTFLNLSQNMF 550
Cdd:PLN00113  510 -KLSGEiPDELSSCKKLVSLDLSHNQLSgQIPASfSEMPVLSQLDLSQNQLSGEIPKNLGN-VESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 270-551 2.47e-28

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 120.34  E-value: 2.47e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 270 SNLTHLTSLTLSNNNLNGSIPSSLLTLPRLTFLHLYSNQLSGRIPNASLPNLQHLIHLDLSKNLFSGQIPS-SLFNlnqL 348
Cdd:PLN00113   66 NNSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRgSIPN---L 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 349 YTLDCSKNKLEGPIPNKTTGFQELNDLRLNDNLLNGTIPSSLLSLPSLVHLVLSNNRLTRHITAI--SSYSLKKLDLSGN 426
Cdd:PLN00113  143 ETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRElgQMKSLKWIYLGYN 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 427 KLQGNIPKSIFNLANLTLLDLSSNNLSDVI--DFQHFSKLQYLktlsLSHNSQLSLTFEPNVnYNFSYLSKLDLSSINLT 504
Cdd:PLN00113  223 NLSGEIPYEIGGLTSLNHLDLVYNNLTGPIpsSLGNLKNLQYL----FLYQNKLSGPIPPSI-FSLQKLISLDLSDNSLS 297

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1379641851 505 -EFP------------------ISGKVPL-------LDSLDLSNNKLNGKVPDWLPEtMNSLTFLNLSQNMFT 551
Cdd:PLN00113  298 gEIPelviqlqnleilhlfsnnFTGKIPValtslprLQVLQLWSNKFSGEIPKNLGK-HNNLTVLDLSTNNLT 369
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
132-563 8.45e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 8.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 132 NLEGEIPTQISHLSKLQSLHLSENYDLIWKETTLKRLLQNATDLRELFLDSTDMSSIRPNSIALLLNQSLSLVTLNLHYT 211
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 212 RLSGKLKRSLIC-LASIQELDMSYNDELQGqlpelscSTSLRIIDLSGCAFEgEIPMYFSNLTHLTSLTLSNNNLNgSIP 290
Cdd:COG4886    82 LSLLLLGLTDLGdLTNLTELDLSGNEELSN-------LTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 291 SSLLTLPRLTFLHLYSNQLSGrIPnASLPNLQHLIHLDLSKNLFSgQIPSSLFNLNQLYTLDCSKNKLEgPIPNKTTGFQ 370
Cdd:COG4886   153 EPLGNLTNLKSLDLSNNQLTD-LP-EELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLT 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 371 ELNDLRLNDNLLngtipssllslpslvhlvlsnnrltRHITAISS-YSLKKLDLSGNKLQgNIPKSiFNLANLTLLDLSS 449
Cdd:COG4886   229 NLETLDLSNNQL-------------------------TDLPELGNlTNLEELDLSNNQLT-DLPPL-ANLTNLKTLDLSN 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 450 NNLSDVIDFQHFSKLQYLKTLSLSHNSQLSLTFEPNVNYNFSYLSKLDLSSINLTEFPISGKVPLLDSLDLSNNKLNGKV 529
Cdd:COG4886   282 NQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1379641851 530 PDWLPETMNSLTFLNLSQNMFTSIDQISMKNEQL 563
Cdd:COG4886   362 LLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-471 8.68e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 8.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 123 LTHLDLSDSNLEGEIPTQISHLSKLQSLHLSENydliwkettlkRLLQNATDLRELFLDSTDMSSIrPNSIALLLNqsls 202
Cdd:COG4886    74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----------EELSNLTNLESLDLSGNQLTDL-PEELANLTN---- 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 203 LVTLNLHYTRLSgKLKRSLICLASIQELDMSYNdELQGQLPELSCSTSLRIIDLSGCAFEgEIPMYFSNLTHLTSLTLSN 282
Cdd:COG4886   138 LKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNN-QLTDLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSG 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 283 NNLNgSIPSSLLTLPRLTFLHLYSNQLSgRIPnaSLPNLQHLIHLDLSKNLFSGqiPSSLFNLNQLYTLDCSKNKLEGPI 362
Cdd:COG4886   215 NQLT-DLPEPLANLTNLETLDLSNNQLT-DLP--ELGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLK 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 363 PNKTTGFQELNDLRLNDNLLNGTIPSSLLSLPSLVHLVLSNNRLTRHITAISSYSLKKLDLSGNKLQGNIPKSIFNLANL 442
Cdd:COG4886   289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                         330       340
                  ....*....|....*....|....*....
gi 1379641851 443 TLLDLSSNNLSDVIDFQHFSKLQYLKTLS 471
Cdd:COG4886   369 LGLLGLLEATLLTLALLLLTLLLLLLTTT 397
PLN03150 PLN03150
hypothetical protein; Provisional
 235-316 1.56e-13

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 73.31  E-value: 1.56e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 235 NDELQGQLP-ELSCSTSLRIIDLSGCAFEGEIPMYFSNLTHLTSLTLSNNNLNGSIPSSLLTLPRLTFLHLYSNQLSGRI 313
Cdd:PLN03150  427 NQGLRGFIPnDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRV 506


                  ...
gi 1379641851 314 PNA 316
Cdd:PLN03150  507 PAA 509
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-386 2.50e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 2.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851  72 VIDLNLGCEGLTGTFNPNSTLFHLVHLQTLNLSYNDFFDShfhykfcgFQSLTHLDLSDSNLEgEIPTQISHLSKLQSLH 151
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSN--------LTNLESLDLSGNQLT-DLPEELANLTNLKELD 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 152 LSENydliwKETTLKRLLQNATDLRELFLDSTDMSSIrPNSIALLLNqslsLVTLNLHYTRLSgklkrsliclasiqeld 231
Cdd:COG4886   143 LSNN-----QLTDLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTN----LKELDLSNNQIT----------------- 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 232 msyndELQGQLPELscsTSLRIIDLSGCAFEgEIPMYFSNLTHLTSLTLSNNNLNgSIPsSLLTLPRLTFLHLYSNQLSG 311
Cdd:COG4886   196 -----DLPEPLGNL---TNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DLP-ELGNLTNLEELDLSNNQLTD 264

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1379641851 312 RIPNASLPNLQhliHLDLSKNLFSGQIPSSLFNLNQLYTLDCSKNKLEGPIPNKTTGFQELNDLRLNDNLLNGTI 386
Cdd:COG4886   265 LPPLANLTNLK---TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-383 1.35e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 1.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851  89 NSTLFHLVHLQTLNLSYNDFfdSHFHYKFCGFQSLTHLDLSDSNLEgEIPTQISHLSKLQSLHLSENydliwKETTLKRL 168
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQL--TDLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNN-----QLTDLPEE 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 169 LQNATDLRELFLDSTDMSSIrPNSIALLLNqslsLVTLNLHYTRLSgKLKRSLICLASIQELDMSYNdELQgQLPELSCS 248
Cdd:COG4886   178 LGNLTNLKELDLSNNQITDL-PEPLGNLTN----LEELDLSGNQLT-DLPEPLANLTNLETLDLSNN-QLT-DLPELGNL 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 249 TSLRIIDLSGCAFEgEIPMyFSNLTHLTSLTLSNNNLNGSIPSSLLTLPRLTFLHLYSNQLSGRIPNASLPNLQHLIHLD 328
Cdd:COG4886   250 TNLEELDLSNNQLT-DLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL 327

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1379641851 329 LSKNLFSGQIPSSLFNLNQLYTLDCSKNKLEGPIPNKTTGFQELNDLRLNDNLLN 383
Cdd:COG4886   328 LLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 272-475 2.58e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.35  E-value: 2.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 272 LTHLTSLTLSNNNLNgSIPSsLLTLPRLTFLHLYSNQLSgRIPNasLPNLQHLIHLDLSKNlfsgQIPS--SLFNLNQLY 349
Cdd:cd21340     1 LKRITHLYLNDKNIT-KIDN-LSLCKNLKVLYLYDNKIT-KIEN--LEFLTNLTHLYLQNN----QIEKieNLENLVNLK 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 350 TLDCSKNKLEgpipnKTTGFQELNDLRlndnllngtipssllslpslvHLVLSNNRL---------TRHITAIsSYSLKK 420
Cdd:cd21340    72 KLYLGGNRIS-----VVEGLENLTNLE---------------------ELHIENQRLppgekltfdPRSLAAL-SNSLRV 124

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1379641851 421 LDLSGNKLQgnIPKSIFNLANLTLLDLSSNNLSDVIDFQH-FSKLQYLKTLSLSHN 475
Cdd:cd21340   125 LNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 254-342 2.95e-12

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 69.46  E-value: 2.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 254 IDLSGCAFEGEIPMYFSNLTHLTSLTLSNNNLNGSIPSSLLTLPRLTFLHLYSNQLSGRIPnASLPNLQHLIHLDLSKNL 333
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP-ESLGQLTSLRILNLNGNS 501


                  ....*....
gi 1379641851 334 FSGQIPSSL 342
Cdd:PLN03150  502 LSGRVPAAL 510
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
282-557 7.96e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 7.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 282 NNNLNGSIPSSLLTLPRLTFLHLYSNQLSGRIPNASLPNLQHLIHLDLSKNLFSGQIPSSLFNLNQLYTLDCSKNKLEGP 361
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 362 IPNKTTGFQELNDLRLNDNLLNGTIPSSLLSLPSLVHLVLSNNRLTRHITAISSY-SLKKLDLSGNKLQgNIPKSIFNLA 440
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLtNLKELDLSNNQLT-DLPEPLGNLT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 441 NLTLLDLSSNNLSDVidFQHFSKLQYLKTLSLSHNsqlSLTFEPNVNYNFSYLSKLDLSSINLTEFPIS-GKVPLLDSLD 519
Cdd:COG4886   160 NLKSLDLSNNQLTDL--PEELGNLTNLKELDLSNN---QITDLPEPLGNLTNLEELDLSGNQLTDLPEPlANLTNLETLD 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1379641851 520 LSNNKLNGkvpdwLPE--TMNSLTFLNLSQNMFTSIDQIS 557
Cdd:COG4886   235 LSNNQLTD-----LPElgNLTNLEELDLSNNQLTDLPPLA 269
PLN03150 PLN03150
hypothetical protein; Provisional
 307-386 3.26e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.44  E-value: 3.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 307 NQ-LSGRIPNaSLPNLQHLIHLDLSKNLFSGQIPSSLFNLNQLYTLDCSKNKLEGPIPNKTTGFQELNDLRLNDNLLNGT 385
Cdd:PLN03150  427 NQgLRGFIPN-DISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGR 505


                  .
gi 1379641851 386 I 386
Cdd:PLN03150  506 V 506
PLN03150 PLN03150
hypothetical protein; Provisional
 53-175 9.25e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 9.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851  53 NGTDCCS----WNGVTC--DTVSGH-VID-LNLGCEGLTGtFNPNsTLFHLVHLQTLNLSYNdffdshfhykfcgfqslt 124
Cdd:PLN03150  393 NGDPCVPqqhpWSGADCqfDSTKGKwFIDgLGLDNQGLRG-FIPN-DISKLRHLQSINLSGN------------------ 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1379641851 125 hldlsdsNLEGEIPTQISHLSKLQSLHLSENY------DLIWKETTLKRLLQNATDL 175
Cdd:PLN03150  453 -------SIRGNIPPSLGSITSLEVLDLSYNSfngsipESLGQLTSLRILNLNGNSL 502
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 269-426 3.22e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 3.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 269 FSNLTHLTSLTLSNNNLNgSIPsSLLTLPRLTFLHLYSNQLSgRIPNasLPNLQHLIHLDLSK-NLFSGQI----PSSLF 343
Cdd:cd21340    42 LEFLTNLTHLYLQNNQIE-KIE-NLENLVNLKKLYLGGNRIS-VVEG--LENLTNLEELHIENqRLPPGEKltfdPRSLA 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 344 NL-NQLYTLDCSKNKLegpipnkttgfQELNDLRLNDNLlngtipssllslpslVHLVLSNNRLTrHITAISS-----YS 417
Cdd:cd21340   117 ALsNSLRVLNISGNNI-----------DSLEPLAPLRNL---------------EQLDASNNQIS-DLEELLDllsswPS 169


                  ....*....
gi 1379641851 418 LKKLDLSGN 426
Cdd:cd21340   170 LRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 418-476 3.59e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.81  E-value: 3.59e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1379641851 418 LKKLDLSGNKLQGNIPKSIFNLANLTLLDLSSNNLSDVIDfQHFSKLQYLKTLSLSHNS 476
Cdd:PLN03150  444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP-ESLGQLTSLRILNLNGNS 501
PLN03150 PLN03150
hypothetical protein; Provisional
 178-283 6.28e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.04  E-value: 6.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 178 LFLDSTDMSSIRPNSIALLLNqslsLVTLNLHYTRLSGKLKRSLICLASIQELDMSYNdELQGQLPE-LSCSTSLRIIDL 256
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRH----LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYN-SFNGSIPEsLGQLTSLRILNL 497

                          90       100
                  ....*....|....*....|....*...
gi 1379641851 257 SGCAFEGEIPMYF-SNLTHLTSLTLSNN 283
Cdd:PLN03150  498 NGNSLSGRVPAALgGRLLHRASFNFTDN 525
PLN03150 PLN03150
hypothetical protein; Provisional
 206-297 1.37e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 206 LNLHYTRLSGKLKRSLICLASIQELDMSyNDELQGQLP-ELSCSTSLRIIDLSGCAFEGEIPMYFSNLTHLTSLTLSNNN 284
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLS-GNSIRGNIPpSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501

                          90
                  ....*....|...
gi 1379641851 285 LNGSIPSSLLTLP 297
Cdd:PLN03150  502 LSGRVPAALGGRL 514
LRR_8 pfam13855
Leucine rich repeat;
417-475 5.24e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.24e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1379641851 417 SLKKLDLSGNKLQGNIPKSIFNLANLTLLDLSSNNLSdVIDFQHFSKLQYLKTLSLSHN 475
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGN 59
PLN03150 PLN03150
hypothetical protein; Provisional
 358-453 5.38e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.96  E-value: 5.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 358 LEGPIPNKTTGFQELNDLRLNDNLLNGTIPSSllslpslvhlvlsnnrltrhITAISsySLKKLDLSGNKLQGNIPKSIF 437
Cdd:PLN03150  430 LRGFIPNDISKLRHLQSINLSGNSIRGNIPPS--------------------LGSIT--SLEVLDLSYNSFNGSIPESLG 487

                          90
                  ....*....|....*.
gi 1379641851 438 NLANLTLLDLSSNNLS 453
Cdd:PLN03150  488 QLTSLRILNLNGNSLS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 493-548 1.50e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.81  E-value: 1.50e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1379641851 493 LSKLD-LSSINLTEFPISGKVPL-------LDSLDLSNNKLNGKVPDWLPEtMNSLTFLNLSQN 548
Cdd:PLN03150  438 ISKLRhLQSINLSGNSIRGNIPPslgsitsLEVLDLSYNSFNGSIPESLGQ-LTSLRILNLNGN 500
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 30-66 1.56e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 39.20  E-value: 1.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1379641851  30 KFKSSFIIgfsqcvPLLKTATWKN-GTDCCSWNGVTCD 66
Cdd:pfam08263  10 AFKSSLND------PPGALSSWNSsSSDPCSWTGVTCD 41
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
265-480 1.69e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 265 IPMYFSNltHLTSLTLSNNNLNgSIPSSLLTlpRLTFLHLYSNQLSgRIPnASLPNLQHLIHLDLSKNL-FSGQIPSSLf 343
Cdd:PRK15370  193 IPACIPE--QITTLILDNNELK-SLPENLQG--NIKTLYANSNQLT-SIP-ATLPDTIQEMELSINRITeLPERLPSAL- 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 344 nlnqlYTLDCSKNKLEGPIPNKTTGFQEL----NDLR-LNDNLLNGTipssllslpslVHLVLSNNRLTrHITAISSYSL 418
Cdd:PRK15370  265 -----QSLDLFHNKISCLPENLPEELRYLsvydNSIRtLPAHLPSGI-----------THLNVQSNSLT-ALPETLPPGL 327

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1379641851 419 KKLDLSGNKLQgNIPKSIfnLANLTLLDLSSNNLSDVIDfqhfSKLQYLKTLSLSHNSQLSL 480
Cdd:PRK15370  328 KTLEAGENALT-SLPASL--PPELQVLDVSKNQITVLPE----TLPPTITTLDVSRNALTNL 382
LRR_8 pfam13855
Leucine rich repeat;
399-452 2.87e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 2.87e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1379641851 399 LVLSNNRLT--RHITAISSYSLKKLDLSGNKLQGNIPKSIFNLANLTLLDLSSNNL 452
Cdd:pfam13855   6 LDLSNNRLTslDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 266-464 4.25e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 266 PMYFSNLTHLTSLTLSNNNLNGSIP---SSLLTLPRLTFLHLYSNQLS---GRIPNASLPNLQH-LIHLDLSKNLFSGQI 338
Cdd:cd00116    74 LQGLTKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLGdrgLRLLAKGLKDLPPaLEKLVLGRNRLEGAS 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 339 P---SSLFNLNQ-LYTLDCSKNKLEGP-IPNKTTGF---QELNDLRLNDNLLN----GTIPSSLLSLPSLVHLVLSNNRL 406
Cdd:cd00116   154 CealAKALRANRdLKELNLANNGIGDAgIRALAEGLkanCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNL 233

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1379641851 407 TRHITA-------ISSYSLKKLDLSGNKLQGNIPKS----IFNLANLTLLDLSSNNLSDVIDFQHFSKL 464
Cdd:cd00116   234 TDAGAAalasallSPNISLLTLSLSCNDITDDGAKDlaevLAEKESLLELDLRGNKFGEEGAQLLAESL 302
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 272-551 4.68e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 4.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 272 LTHLTSLTLSNNNLNGS----IPSSLLTLPRLTFLHLYSNQLsGRIPNA------SLPNLQHLIHLDLSKNLFSGQIPSS 341
Cdd:cd00116    22 LLCLQVLRLEGNTLGEEaakaLASALRPQPSLKELCLSLNET-GRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 342 LFNLNQLYTLDcsknklegpipnkttgfqelndlrlndnllngtipssllslpslvHLVLSNNRLTRHITAI-------S 414
Cdd:cd00116   101 LESLLRSSSLQ---------------------------------------------ELKLNNNGLGDRGLRLlakglkdL 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 415 SYSLKKLDLSGNKLQGNIPKSIFNL--ANLTL--LDLSSNNLSD------VIDFQHFSKlqyLKTLSLSHN-------SQ 477
Cdd:cd00116   136 PPALEKLVLGRNRLEGASCEALAKAlrANRDLkeLNLANNGIGDagiralAEGLKANCN---LEVLDLNNNgltdegaSA 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 478 LSLTFEPNVNynfsyLSKLDLSSINLTEFPIS-------GKVPLLDSLDLSNNKLN----GKVPDWLPEtMNSLTFLNLS 546
Cdd:cd00116   213 LAETLASLKS-----LEVLNLGDNNLTDAGAAalasallSPNISLLTLSLSCNDITddgaKDLAEVLAE-KESLLELDLR 286


                  ....*
gi 1379641851 547 QNMFT 551
Cdd:cd00116   287 GNKFG 291
LRR_8 pfam13855
Leucine rich repeat;
249-309 7.38e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 7.38e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1379641851 249 TSLRIIDLSGCAFEGEIPMYFSNLTHLTSLTLSNNNLNGSIPSSLLTLPRLTFLHLYSNQL 309
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 120-307 1.40e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 120 FQSLTHLDLSDSNLEgEIPTqISHLSKLQSLHLSENYdliwkettLKRL--LQNATDLRELFLDSTDMSSIRPnsiallL 197
Cdd:cd21340     1 LKRITHLYLNDKNIT-KIDN-LSLCKNLKVLYLYDNK--------ITKIenLEFLTNLTHLYLQNNQIEKIEN------L 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851 198 NQSLSLVTLNLHY---TRLSGklkrsLICLASIQELDMSYNdelqgQLPE-----------LSCSTSLRIIDLSGCAFeg 263
Cdd:cd21340    65 ENLVNLKKLYLGGnriSVVEG-----LENLTNLEELHIENQ-----RLPPgekltfdprslAALSNSLRVLNISGNNI-- 132

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1379641851 264 EIPMYFSNLTHLTSLTLSNNNLN--GSIPSSLLTLPRLTFLHLYSN 307
Cdd:cd21340   133 DSLEPLAPLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 202-520 2.75e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 40.63  E-value: 2.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851  202 SLVTLNLHYTRLSgKLKRSLICLASIQELDMSYNDELQgQLPELSCSTSLRIIDLSGCAFEGEIPMYFSNLTHLTSLTLS 281
Cdd:PLN03210   612 NLVKLQMQGSKLE-KLWDGVHSLTGLRNIDLRGSKNLK-EIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMS 689

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851  282 NNNLNGSIPSSlltlprLTFLHLYSNQLSGRIPNASLPNLQHLIH-LDLSKNLFSgQIPSSLF--NLNQLYTLDCSKNKL 358
Cdd:PLN03210   690 RCENLEILPTG------INLKSLYRLNLSGCSRLKSFPDISTNISwLDLDETAIE-EFPSNLRleNLDELILCEMKSEKL 762

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851  359 EGPIPNKTTgfqelndlrlndnllngtipssllslpslvhlvlsnnrltrhITAISSYSLKKLDLSGNKLQGNIPKSIFN 438
Cdd:PLN03210   763 WERVQPLTP------------------------------------------LMTMLSPSLTRLFLSDIPSLVELPSSIQN 800

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379641851  439 LANLTLLDLSsnNLSDVIDFQHFSKLQYLKTLSLSHNSQLSlTFePNVNYNfsyLSKLDLSSINLTEFPIS-GKVPLLDS 517
Cdd:PLN03210   801 LHKLEHLEIE--NCINLETLPTGINLESLESLDLSGCSRLR-TF-PDISTN---ISDLNLSRTGIEEVPWWiEKFSNLSF 873


                   ...
gi 1379641851  518 LDL 520
Cdd:PLN03210   874 LDM 876
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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