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Conserved domains on  [gi|1378756777|gb|AWA44224|]
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sugar ABC transporter permease [Trueperella pyogenes]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
1-295 1.50e-73

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 227.71  E-value: 1.50e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777   1 MSTIIPASPKARKKRRTePVYYFFLLPSVILFTLAITIPGLVGIFYSFTDSIGIG-DWKFIGLTNYKALFSDPAILQAYL 79
Cdd:COG1175     1 MTTTTSAAARRRRRRRR-LAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGpPPEFVGLDNYARLFTDPRFWNALG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  80 FTFGFAIVTVTVVNLVAFLLALGLTAKIRFTTTLRAIFVVPMVISGIIISYVFNFLFSNSLPALGEALGVSWLET-SLLA 158
Cdd:COG1175    80 NTLLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPiNWLG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 159 NPNLAWVAIVIVTAWQAIPSTMLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLVFGYVVINMILGLKNFLNAYDI 238
Cdd:COG1175   160 DPSLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1378756777 239 IVGLTNGGPGTATRSIAMTIIS-GFNGGDYAYQMANATIFFFVAIVIALLQLSATRGR 295
Cdd:COG1175   240 VYVLTGGGPGNSTTTLVLYIYQtAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRR 297
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
1-295 1.50e-73

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 227.71  E-value: 1.50e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777   1 MSTIIPASPKARKKRRTePVYYFFLLPSVILFTLAITIPGLVGIFYSFTDSIGIG-DWKFIGLTNYKALFSDPAILQAYL 79
Cdd:COG1175     1 MTTTTSAAARRRRRRRR-LAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGpPPEFVGLDNYARLFTDPRFWNALG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  80 FTFGFAIVTVTVVNLVAFLLALGLTAKIRFTTTLRAIFVVPMVISGIIISYVFNFLFSNSLPALGEALGVSWLET-SLLA 158
Cdd:COG1175    80 NTLLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPiNWLG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 159 NPNLAWVAIVIVTAWQAIPSTMLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLVFGYVVINMILGLKNFLNAYDI 238
Cdd:COG1175   160 DPSLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1378756777 239 IVGLTNGGPGTATRSIAMTIIS-GFNGGDYAYQMANATIFFFVAIVIALLQLSATRGR 295
Cdd:COG1175   240 VYVLTGGGPGNSTTTLVLYIYQtAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRR 297
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
25-288 2.09e-17

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 80.26  E-value: 2.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  25 LLPSVILFTLAITIPGLVGIFYSF--TDSIGIGDwKFIGLTNYKALFSDPAILQAYLFTFGFAIVTVTVVNLVAFLLALG 102
Cdd:PRK10561    3 VAPQLIITVIFFIWPAGEALWYSLqsVDPFGFSS-QFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 103 LTAKIRFTTTLRAIFVVPMVISGIIISYVFNFLFSNSLPALGEALGVSWLETSLLANPNLAWVAIVIVTAWQAIPSTMLI 182
Cdd:PRK10561   82 VDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYDWNHAQNSGQAMFLVVFASVWKQISYNFLF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 183 YIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLV----FGYVVINMILGlknFLNAYDIIVGLTNGGPGTATRSIAMTI 258
Cdd:PRK10561  162 FFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIapvsFFLLVVNLVYA---FFDTFPVIDAATSGGPVQATTTLIYKI 238

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1378756777 259 I-SGFNGGDYAYQMANATIFFFVAIVIALLQ 288
Cdd:PRK10561  239 YrEGFTGLDLSSSAAQSVVLMFLVIVLTVVQ 269
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 30-215 5.70e-09

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 56.61  E-value: 5.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  30 ILFTLAITIPGLVGIFYSFTDSIGIGDWKFIGLTNYKALFSDPAILQAYLFTFGFAIVTVTVVNLVAFLLALGLT-AKIR 108
Cdd:TIGR03262   8 AGMILALLLFLLLPLLALLTKSVYDSDGDFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYALTrSRIP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 109 FTTTLRAIFVVPMVISGIIISYVFNFLFSNSlpalgealGVswLETSLLANPNLAWVAIVIVTAWQAIPSTMLIYIAGLL 188
Cdd:TIGR03262  88 GKGAFRLVALLPLLAPSLLPAISLIYLFGNQ--------GL--LKGLLGGFSIYGFWGIVIGEVFYTFPHALMILVTALS 157

                         170       180
                  ....*....|....*....|....*..
gi 1378756777 189 SVPGEVYEAAEIDGASSLQKLTRVTIP 215
Cdd:TIGR03262 158 LADGRLYEAARAMGASPWRTFFTVTLP 184
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 134-287 3.55e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 43.44  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 134 FLFSNSLPALgeALGVSWLETSLLANPNLAWVAIVIVTAWQAIPSTMLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVT 213
Cdd:pfam00528  24 IDLLQALPSF--VLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKII 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1378756777 214 IPLVFGYVVINMILGLKNFLNAYDIIVGLTNGGPgtatrsIAMTIISGFNGGDYAYQMANATIFFFVAIVIALL 287
Cdd:pfam00528 102 LPNALPPILTGLALAFGGALGGAVLLEFLGSWPG------LGLLLIEAILGYDYPEIQGPVLAAALILLLLNLL 169
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 78-282 4.81e-05

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 43.42  E-value: 4.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  78 YLFTFGFAIVTVTVVNLVAFLLALGLTAKIR-----FTTTLRAIFVVPMVISGIIISYVFNFLFSNSLpalgealgvswl 152
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGkldrlLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGI------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 153 etsllaNPNLAWVAIVIVTAWQAiPSTMLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLVFGYVVINMILGLKNF 232
Cdd:cd06261    69 ------LPGLGLPALILALLLIA-PFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARA 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1378756777 233 LNAYDIIVGLTNGGPGTATrSIAMTIISGFNGGDYAYQMANATIFFFVAI 282
Cdd:cd06261   142 LGEFALVSFLGGGEAPGPG-TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
1-295 1.50e-73

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 227.71  E-value: 1.50e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777   1 MSTIIPASPKARKKRRTePVYYFFLLPSVILFTLAITIPGLVGIFYSFTDSIGIG-DWKFIGLTNYKALFSDPAILQAYL 79
Cdd:COG1175     1 MTTTTSAAARRRRRRRR-LAAYLFLLPALLLLLVFVLYPLLYTLYLSFTDWNLLGpPPEFVGLDNYARLFTDPRFWNALG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  80 FTFGFAIVTVTVVNLVAFLLALGLTAKIRFTTTLRAIFVVPMVISGIIISYVFNFLFSNSLPALGEALGVSWLET-SLLA 158
Cdd:COG1175    80 NTLLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGLEPiNWLG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 159 NPNLAWVAIVIVTAWQAIPSTMLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLVFGYVVINMILGLKNFLNAYDI 238
Cdd:COG1175   160 DPSLALPAVIIVTVWKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDL 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1378756777 239 IVGLTNGGPGTATRSIAMTIIS-GFNGGDYAYQMANATIFFFVAIVIALLQLSATRGR 295
Cdd:COG1175   240 VYVLTGGGPGNSTTTLVLYIYQtAFQQFDFGYASAIAVVLFLIILVLTLLQLRLLRRR 297
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 1-269 1.73e-24

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 100.55  E-value: 1.73e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777   1 MSTIIPASPKARKKRRT--------EPVYYFFLLPSVILFTL--AITIPGLVGIFYSFTDSIGIGDWKFIGLTNYKALFS 70
Cdd:COG4209     1 MSTTAAKAKRKKKKRKKsflkrlkrDWQLYLMLLPGLIYLLIfsYLPMYGIVIAFKDYNPFKGIFGSPWVGLKNFKFLFS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  71 DPAILQAYLFTFGFAIVTVTVVNLVAFLLALGLT--AKIRFTTTLRAIFVVPMVISGIIISYVFNFLFSNSLPALGEALG 148
Cdd:COG4209    81 SPDFWRVLRNTLLISLLKLVFGFPLPIILALLLNelRSKRFKKTVQTISYLPHFLSWVVVAGIVYQFLSPDTGLVNQLLR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 149 VSWLET-SLLANPNLAWVAIVIVTAWQAIPSTMLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLVFGYVVINMIL 227
Cdd:COG4209   161 ALGGEPiNFLTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIRPTIVILLIL 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1378756777 228 GLKNFLNA-YDIIVGLTNGgpgtATRSIAMTI-----ISGFNGGDYAY 269
Cdd:COG4209   241 NIGNILNVgFEQIYLLYNP----LNYSTSDVIdtyvyRIGLQNGDYSY 284
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 22-298 3.90e-18

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 82.50  E-value: 3.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  22 YFFLLPSVILFTLAITIPGLVGIFYSFTDSIGIGDWKF-IGLTNYKALFSDPAILQAYLFTFGFAIVTVTVVNLVAFLLA 100
Cdd:COG1176    12 LLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPgFTLENYARLFTDPLYLKVLLRTLWIALLTTLICLLLGYPIA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 101 LGLT-AKIRFTTTLRAIFVVPMVISGIIISYVFNFLFSNS--LPALGEALGVSWLETSLLANPnlawVAIVIVTAWQAIP 177
Cdd:COG1176    92 YFLArAPPRWRNLLLLLVILPFWTSFLVRTYAWIVLLGRNglLNSLLLALGLIDEPLRLLYTE----FAVVIGLVYVYLP 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 178 STMLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLVFGYVVINMILGLKNFLNAYdIIVGLTnGGPGTATrsIAMT 257
Cdd:COG1176   168 FMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAF-VTPALL-GGGKVLM--IGNL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1378756777 258 IIS-GFNGGDYAYQMANATIFFFVAIVIALLQLSATRGRNEL 298
Cdd:COG1176   244 IYQqFLSALNWPLAAALAVVLLLIVLLVLLLYLRLLRRRRLL 285
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
25-288 2.09e-17

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 80.26  E-value: 2.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  25 LLPSVILFTLAITIPGLVGIFYSF--TDSIGIGDwKFIGLTNYKALFSDPAILQAYLFTFGFAIVTVTVVNLVAFLLALG 102
Cdd:PRK10561    3 VAPQLIITVIFFIWPAGEALWYSLqsVDPFGFSS-QFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 103 LTAKIRFTTTLRAIFVVPMVISGIIISYVFNFLFSNSLPALGEALGVSWLETSLLANPNLAWVAIVIVTAWQAIPSTMLI 182
Cdd:PRK10561   82 VDYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGYDWNHAQNSGQAMFLVVFASVWKQISYNFLF 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 183 YIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLV----FGYVVINMILGlknFLNAYDIIVGLTNGGPGTATRSIAMTI 258
Cdd:PRK10561  162 FFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIapvsFFLLVVNLVYA---FFDTFPVIDAATSGGPVQATTTLIYKI 238

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1378756777 259 I-SGFNGGDYAYQMANATIFFFVAIVIALLQ 288
Cdd:PRK10561  239 YrEGFTGLDLSSSAAQSVVLMFLVIVLTVVQ 269
malF PRK10999
maltose ABC transporter permease MalF;
59-293 1.93e-15

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 76.15  E-value: 1.93e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  59 FIGLTNYKALFSDPAI----LQAYLFTFGFAIVTVTVVNLVAFLLAL-----GLTAKIRFTTTLRAIFVVPMVISGIIIS 129
Cdd:PRK10999  264 TIGWKNFTRVFTDEGIqkpfIAIFIWTVVFSLLTVVLTVAVGMVLAClvqweALKGKAVYRVLLILPYAVPSFISILIFK 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 130 YVFNFLFSNSLPALGEALGVS--WLetsllANPNLAWVAIVIVTAWQAIPsTMLIYIAGLL-SVPGEVYEAAEIDGASSL 206
Cdd:PRK10999  344 GLFNQSFGEINMMLSALFGIKpaWF-----SDPTLAKTMILIVNTWLGYP-YMMILCMGLLkAIPDDLYEASAMDGAGPF 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 207 QKLTRVTIPLVFGYVVINMILGLK-NFlNAYDIIVGLTNGGP---GTATRS------IAMTIISGFNGG---DYAYQMAN 273
Cdd:PRK10999  418 QNFFKITLPLLIKPLTPLMIASFAfNF-NNFVLIQLLTNGGPdmiGTTTPAgytdllVSYTYRIAFEGGggqDFGLAAAI 496

                         250       260
                  ....*....|....*....|
gi 1378756777 274 ATIFFFVAIVIALLQLSATR 293
Cdd:PRK10999  497 ATLIFLLVGALAILNLKATK 516
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 23-287 3.37e-14

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 70.91  E-value: 3.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  23 FFLLPSVILFTLAITIPGLVGIFYSFTDS-IGIGDWKFIGLTNYKALFSDPAILQAYLFTFGFAIVTVTVVNLVAFLLAL 101
Cdd:COG1177     7 LLLRLFLALVLLFLYLPILVLVLYSFNDSwFLTFPPEGFTLRWYAELFSDPRLLDALLNSLLIALLSTLLATVLGTPAAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 102 GLT-AKIRFTTTLRAIFVVPMVISGIIISYVFNFLFSnslpalgeALGVSwletsllanpnLAWVAIVIVTAWQAIPSTM 180
Cdd:COG1177    87 ALArYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFS--------ALGLS-----------GGLWGLILAHVVFTLPFVV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 181 LIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLVFGYVVINMILGlknFLNAYD-IIVGLTNGGPGTATrsIAMTII 259
Cdd:COG1177   148 LVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLA---FTLSFDeFVITLFLAGPGVTT--LPVYIY 222

                         250       260
                  ....*....|....*....|....*...
gi 1378756777 260 SGFNGGDYAYQMANATIFFFVAIVIALL 287
Cdd:COG1177   223 SMIRRGISPEINALSTLLILLSLLLLLL 250
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
22-217 6.06e-12

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 65.57  E-value: 6.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  22 YFFLLPSVILFTLAITIPGLVGIFYSFTDsigigdwkfiGLTNYKALFSDPAILQAYLFTFGFAIVTVTVVNLVAFLLAL 101
Cdd:COG1178    10 RLLLLLLALLLALLVLLPLLALLLRAFTD----------GLANFWALLSDPYLWRALGNTLLLALLVTLLSLLLGVPLAW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 102 GLTA-KIRFTTTLRAIFVVPMVISGIIISYVFNFLFSNSLPalgeaLGVSWLETSLLANPNL-AWVAIVIVTAWQAIPST 179
Cdd:COG1178    80 LLARtDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPNGL-----LNTLLRALFGLEPPDIyGLGGIILVLVLFNYPYV 154

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1378756777 180 MLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLV 217
Cdd:COG1178   155 YLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLL 192
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
29-295 2.23e-11

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 64.03  E-value: 2.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  29 VILFTLAITIPGLVGIFYSFTDSIGIGdwkfIGLTNYKALFSDPAILQAYLFTFGFAIVTVTVVNLVAFLLALGLT-AKI 107
Cdd:COG1178   295 LLLVLLGLLLPLLALLLWSLTKALDDN----LTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRrRRG 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 108 RFTTTLRAIFVVPMVISGIIISYVFNFLFSNSLPALgealgvswletslLANpnlAWVAIVIVTAWQAIPSTMLIYIAGL 187
Cdd:COG1178   371 RLARLLDRLAMLPYAVPGIVLGLGLLLLFNRPLPLL-------------LYG---TLAILVLAYVVRFLPFALRSLEAAL 434

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 188 LSVPGEVYEAAEIDGASSLQKLTRVTIPLVFGYVVINMILGLKNFLNAYDIIVGLtnGGPGTATrsIAMTIISGFNGGDY 267
Cdd:COG1178   435 AQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLL--RPPGFET--LAVLIYQLASSGRY 510

                         250       260
                  ....*....|....*....|....*...
gi 1378756777 268 AYQMANATIFFFVAIVIALLQLSATRGR 295
Cdd:COG1178   511 GEAAALALLLVLVSLLPVLLLERLLGRR 538
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 7-287 4.29e-10

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 59.34  E-value: 4.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777   7 ASPKARKKRRTEPVYYFFLlpsvILFTLAITIPGLVGIFYSFTDSIGI--GDWKFI----GLTNYKALFSDPAILQAYLF 80
Cdd:COG0395     3 ATARRRRRRLGRILLYLLL----ILLALLFLFPLYWMVVTSFKPPAEIfsGPPSLLpsefTLENYRAAFTDGPFGRYLLN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  81 TFGFAIVTVTVVNLVAFLLALGLtAKIRF--TTTLRAIFVVPMVISGIIISYVFNFLFSNslpalgeaLGvsWLETslla 158
Cdd:COG0395    79 SLIVAVVSTVLSLLLSSLAAYAL-ARFRFrgRKLLFLLILATLMIPGQVLLIPLYLLFRQ--------LG--LLNT---- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 159 npnlaWVAIVIVTAWQAIPSTMLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLVFGYVVINMILglkNFLNAY-D 237
Cdd:COG0395   144 -----YWGLILPYLAFGLPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIF---TFIGAWnD 215

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1378756777 238 IIVGLT-NGGPGTATRSIAMTIISGFNGGDYAYQMANATIFFFVAIVIALL 287
Cdd:COG0395   216 FLWPLIlLTSPDLRTLPVGLASFQGQYGTDWGLLMAAAVIATLPVLILFLF 266
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 30-215 5.70e-09

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 56.61  E-value: 5.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  30 ILFTLAITIPGLVGIFYSFTDSIGIGDWKFIGLTNYKALFSDPAILQAYLFTFGFAIVTVTVVNLVAFLLALGLT-AKIR 108
Cdd:TIGR03262   8 AGMILALLLFLLLPLLALLTKSVYDSDGDFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYALTrSRIP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 109 FTTTLRAIFVVPMVISGIIISYVFNFLFSNSlpalgealGVswLETSLLANPNLAWVAIVIVTAWQAIPSTMLIYIAGLL 188
Cdd:TIGR03262  88 GKGAFRLVALLPLLAPSLLPAISLIYLFGNQ--------GL--LKGLLGGFSIYGFWGIVIGEVFYTFPHALMILVTALS 157

                         170       180
                  ....*....|....*....|....*..
gi 1378756777 189 SVPGEVYEAAEIDGASSLQKLTRVTIP 215
Cdd:TIGR03262 158 LADGRLYEAARAMGASPWRTFFTVTLP 184
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 14-287 9.58e-07

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 48.98  E-value: 9.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  14 KRRTEPVYYFFLLPSVILFTLAITIPGLVGIFYSFTdsigigdwkfIGLTNYKALFSDPAILQAYLFTFGFAIVTVTVVN 93
Cdd:COG0555     2 SRRVLPGFGLTLGLTLLYLSLIVLLPLAALVLKAAG----------LGWAEFWAVLTSPRVLAALKLSLGTALIAALINL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  94 LVAFLLALGLTakiRFTTTLRAI--------FVVPMVISGIIISYVF--NFLFSNSLpalgEALGVSWLETsllanpnla 163
Cdd:COG0555    72 VFGLPLAWVLV---RYRFPGKRLvdalvdlpFALPTAVAGIALLLLFgpNGWLGQLL----APLGIKVAFT--------- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 164 WVAIVIVTAWQAIPSTMLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLVFGYVVINMILGLKNFLNAYDIIVGLT 243
Cdd:COG0555   136 PLGIVLAQTFVSLPFVVRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALLTGFALAFARALGEFGAVIFIA 215

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1378756777 244 NGGPGTaTRSIAMTIISGFNGGDYAYQMANATIFFFVAIVIALL 287
Cdd:COG0555   216 GNLPMK-TEILPLLIYLKLEEGDYAGATAIALVLLLISFLLLLL 258
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 134-287 3.55e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 43.44  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 134 FLFSNSLPALgeALGVSWLETSLLANPNLAWVAIVIVTAWQAIPSTMLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVT 213
Cdd:pfam00528  24 IDLLQALPSF--VLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKII 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1378756777 214 IPLVFGYVVINMILGLKNFLNAYDIIVGLTNGGPgtatrsIAMTIISGFNGGDYAYQMANATIFFFVAIVIALL 287
Cdd:pfam00528 102 LPNALPPILTGLALAFGGALGGAVLLEFLGSWPG------LGLLLIEAILGYDYPEIQGPVLAAALILLLLNLL 169
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 78-282 4.81e-05

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 43.42  E-value: 4.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777  78 YLFTFGFAIVTVTVVNLVAFLLALGLTAKIR-----FTTTLRAIFVVPMVISGIIISYVFNFLFSNSLpalgealgvswl 152
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGkldrlLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGI------------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1378756777 153 etsllaNPNLAWVAIVIVTAWQAiPSTMLIYIAGLLSVPGEVYEAAEIDGASSLQKLTRVTIPLVFGYVVINMILGLKNF 232
Cdd:cd06261    69 ------LPGLGLPALILALLLIA-PFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARA 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1378756777 233 LNAYDIIVGLTNGGPGTATrSIAMTIISGFNGGDYAYQMANATIFFFVAI 282
Cdd:cd06261   142 LGEFALVSFLGGGEAPGPG-TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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