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Conserved domains on  [gi|1375633084|gb|AVW81918|]
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transcriptional regulator ICP4 [Felid alphaherpesvirus 1]

Protein Classification

PHA03307 family protein( domain architecture ID 11476204)

PHA03307 family protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-1326 0e+00

transcriptional regulator ICP4; Provisional


:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1325.95  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084   16 RFPQIDLFDLIEDFTDGREEFEFLGDTNSDvesrgRPQDLLYGSQGFLVSPPGDKDEVFFDFGKTPDDVNRVGN------ 89
Cdd:PHA03307     1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGD-----AADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTgpppgp 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084   90 -------------PTSGGTKTLTSPRPTRETITSGPTTKPPPPPTIHSAASPETPVPDIIEMLRRV--------QEDLGV 148
Cdd:PHA03307    76 gteapanesrstpTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVgspgpppaASPPAA 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  149 SESHGRSTSDTETCSHPSNALSITDSSAHSPSSVGVCDVTECDSLGARDYSRGRRSPISVGSMSPGPRRG---------- 218
Cdd:PHA03307   156 GASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGrsaaddagas 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  219 -------------------RRSRSGSSSSSSSSSSSSSGSSSTGSRSSSSSSSSTSRSPSPPAPPNRELKPGTPSPPRPA 279
Cdd:PHA03307   236 ssdssssessgcgwgpeneCPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRAS 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  280 GEGSPITNDVIASITPQSNVVGSASTTPGATLTDGATLTDGPGDTTPKRRRRRGPLSRPP-------GSRLPRAVRGLLP 352
Cdd:PHA03307   316 SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPsspaasaGRPTRRRARAAVA 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  353 RAERISERTSVFGIQRPP--------------TTGPLLTPTGEVWPDCDPPCEGRVRYGGIGDSREGLWDAPEIKSAAER 418
Cdd:PHA03307   396 GRARRRDATGRFPAGRPRpspldagaasgafyARYPLLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAAR 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  419 YAVDPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPDQILAQFCQRAIHGPRGHGSFITGSVANPLPH 498
Cdd:PHA03307   476 YEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQKKFQAPRGSGSFITGSVARPVPH 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  499 VGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARPYLLGDHRTDcirsspgiadaipdappktpts 578
Cdd:PHA03307   556 IGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAADTGAG---------------------- 613

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  579 sdrvlmvsedilallqstlAGGTTRGTGDPTQIPTPGMGGENPRDLAETCTLACTAVFDSLIFHCGGVDRMPGLfeppsm 658
Cdd:PHA03307   614 -------------------AAAPAPAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGL------ 668

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  659 arsfpsvaKYPSPVCPPDALCAHPDVIEAVTARLYSLRDLVELSRIRGgeAPPERLSRDDLQLVVHSLLLVARTLAPLVR 738
Cdd:PHA03307   669 --------AFPRPACPPRALEACPARLESWLRELRDLRDAVYLARLRG--DLPVAGGREERVAAVRAVSLVARTVAPLVR 738

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  739 YNIDVARKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPT--------PRATASGNRAGGVTVEEISPPRSSNKMQQ 810
Cdd:PHA03307   739 YSPRRARARASAWDITDALFSNPSLVPAKLAEALALLEPAEPQrgagssppVRAEAAFRRPGRLRRSGPAADAASRTASK 818

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  811 RRDVHNPVAGG---CDPLQQSPSNFRPLSPHltrpqsSIRCKRKSEPLPRGHASGNLPIDAVRGEEMRAHPPTDAPPPTK 887
Cdd:PHA03307   819 RKSRSHTPDGGsesSGPARPPGAAARPPPAR------SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAA 892

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  888 KRAGPPRGP-----------LGPMPLGGPSPKGGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAIT 956
Cdd:PHA03307   893 AAAPPAGAPaprprpaprvkLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALA 972

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  957 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAHQNPNRDSRHTPAWSE 1036
Cdd:PHA03307   973 FDPEALAEIAARCGGPPPRSGSAFGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSP 1052

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1037 TKGGLSTLLAALGNRLLSPESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPED 1116
Cdd:PHA03307  1053 ERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPED 1132

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1117 WPATGPAVSHYHLYIRATVTPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTV 1196
Cdd:PHA03307  1133 WPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTV 1212

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1197 RTDAGDRTPVPMLPREYRQRVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALAST 1276
Cdd:PHA03307  1213 RTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAG 1292

                         1370      1380      1390      1400      1410
                   ....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1277 dPTRIPAVVRAFCRTALLAPDTEAPPLILTPADPQSAIIENIPGVTWDSG 1326
Cdd:PHA03307  1293 -PDELPAVVRAFCRAALLEPDPEAPPLVLPPSAAAEAAHARAPRVTWAKS 1341
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-1326 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1325.95  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084   16 RFPQIDLFDLIEDFTDGREEFEFLGDTNSDvesrgRPQDLLYGSQGFLVSPPGDKDEVFFDFGKTPDDVNRVGN------ 89
Cdd:PHA03307     1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGD-----AADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTgpppgp 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084   90 -------------PTSGGTKTLTSPRPTRETITSGPTTKPPPPPTIHSAASPETPVPDIIEMLRRV--------QEDLGV 148
Cdd:PHA03307    76 gteapanesrstpTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVgspgpppaASPPAA 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  149 SESHGRSTSDTETCSHPSNALSITDSSAHSPSSVGVCDVTECDSLGARDYSRGRRSPISVGSMSPGPRRG---------- 218
Cdd:PHA03307   156 GASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGrsaaddagas 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  219 -------------------RRSRSGSSSSSSSSSSSSSGSSSTGSRSSSSSSSSTSRSPSPPAPPNRELKPGTPSPPRPA 279
Cdd:PHA03307   236 ssdssssessgcgwgpeneCPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRAS 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  280 GEGSPITNDVIASITPQSNVVGSASTTPGATLTDGATLTDGPGDTTPKRRRRRGPLSRPP-------GSRLPRAVRGLLP 352
Cdd:PHA03307   316 SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPsspaasaGRPTRRRARAAVA 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  353 RAERISERTSVFGIQRPP--------------TTGPLLTPTGEVWPDCDPPCEGRVRYGGIGDSREGLWDAPEIKSAAER 418
Cdd:PHA03307   396 GRARRRDATGRFPAGRPRpspldagaasgafyARYPLLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAAR 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  419 YAVDPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPDQILAQFCQRAIHGPRGHGSFITGSVANPLPH 498
Cdd:PHA03307   476 YEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQKKFQAPRGSGSFITGSVARPVPH 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  499 VGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARPYLLGDHRTDcirsspgiadaipdappktpts 578
Cdd:PHA03307   556 IGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAADTGAG---------------------- 613

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  579 sdrvlmvsedilallqstlAGGTTRGTGDPTQIPTPGMGGENPRDLAETCTLACTAVFDSLIFHCGGVDRMPGLfeppsm 658
Cdd:PHA03307   614 -------------------AAAPAPAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGL------ 668

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  659 arsfpsvaKYPSPVCPPDALCAHPDVIEAVTARLYSLRDLVELSRIRGgeAPPERLSRDDLQLVVHSLLLVARTLAPLVR 738
Cdd:PHA03307   669 --------AFPRPACPPRALEACPARLESWLRELRDLRDAVYLARLRG--DLPVAGGREERVAAVRAVSLVARTVAPLVR 738

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  739 YNIDVARKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPT--------PRATASGNRAGGVTVEEISPPRSSNKMQQ 810
Cdd:PHA03307   739 YSPRRARARASAWDITDALFSNPSLVPAKLAEALALLEPAEPQrgagssppVRAEAAFRRPGRLRRSGPAADAASRTASK 818

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  811 RRDVHNPVAGG---CDPLQQSPSNFRPLSPHltrpqsSIRCKRKSEPLPRGHASGNLPIDAVRGEEMRAHPPTDAPPPTK 887
Cdd:PHA03307   819 RKSRSHTPDGGsesSGPARPPGAAARPPPAR------SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAA 892

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  888 KRAGPPRGP-----------LGPMPLGGPSPKGGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAIT 956
Cdd:PHA03307   893 AAAPPAGAPaprprpaprvkLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALA 972

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  957 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAHQNPNRDSRHTPAWSE 1036
Cdd:PHA03307   973 FDPEALAEIAARCGGPPPRSGSAFGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSP 1052

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1037 TKGGLSTLLAALGNRLLSPESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPED 1116
Cdd:PHA03307  1053 ERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPED 1132

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1117 WPATGPAVSHYHLYIRATVTPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTV 1196
Cdd:PHA03307  1133 WPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTV 1212

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1197 RTDAGDRTPVPMLPREYRQRVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALAST 1276
Cdd:PHA03307  1213 RTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAG 1292

                         1370      1380      1390      1400      1410
                   ....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1277 dPTRIPAVVRAFCRTALLAPDTEAPPLILTPADPQSAIIENIPGVTWDSG 1326
Cdd:PHA03307  1293 -PDELPAVVRAFCRAALLEPDPEAPPLVLPPSAAAEAAHARAPRVTWAKS 1341
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 909-1333 8.50e-158

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 482.96  E-value: 8.50e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  909 GGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAITFDPGALATIAARCTGPRRQEGTG--------- 979
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIAARVANALPGGGDYnsneiitsa 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  980 ----LGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAhQNPNRDSrhTPAWSETKGGLSTLLAALGNRLLSP 1055
Cdd:pfam03585   81 asraFGPPTATSKLRRRTAWMRQIPDPEDVRIVVLYSPLPGEDLF-CVPAPDT--PPKWSNKRGGLSFLLAALSNRLCLP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1056 ESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPEDWPATGPAVSHYHLYIRATV 1135
Cdd:pfam03585  158 KTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHTYMKCII 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1136 TPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTVRTDAGDRTPVPMLPREYRQ 1215
Cdd:pfam03585  238 SPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPREYRA 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1216 RVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALASTDPTRIPAVVRAFCRTALLA 1295
Cdd:pfam03585  318 AVLPVFDGCKDLARQSRGLGLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHVPTARNFCRSALLE 397

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1375633084 1296 PDTEAPPLILTP---------ADPQSAIIENIPGVTWDSGFGKQETV 1333
Cdd:pfam03585  398 PDPEARPLVLHIpegtcsalaEDMVASALPPCPRITWGQGFGHEEGG 444
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-1326 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1325.95  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084   16 RFPQIDLFDLIEDFTDGREEFEFLGDTNSDvesrgRPQDLLYGSQGFLVSPPGDKDEVFFDFGKTPDDVNRVGN------ 89
Cdd:PHA03307     1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGD-----AADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTgpppgp 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084   90 -------------PTSGGTKTLTSPRPTRETITSGPTTKPPPPPTIHSAASPETPVPDIIEMLRRV--------QEDLGV 148
Cdd:PHA03307    76 gteapanesrstpTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVgspgpppaASPPAA 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  149 SESHGRSTSDTETCSHPSNALSITDSSAHSPSSVGVCDVTECDSLGARDYSRGRRSPISVGSMSPGPRRG---------- 218
Cdd:PHA03307   156 GASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGrsaaddagas 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  219 -------------------RRSRSGSSSSSSSSSSSSSGSSSTGSRSSSSSSSSTSRSPSPPAPPNRELKPGTPSPPRPA 279
Cdd:PHA03307   236 ssdssssessgcgwgpeneCPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRAS 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  280 GEGSPITNDVIASITPQSNVVGSASTTPGATLTDGATLTDGPGDTTPKRRRRRGPLSRPP-------GSRLPRAVRGLLP 352
Cdd:PHA03307   316 SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPsspaasaGRPTRRRARAAVA 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  353 RAERISERTSVFGIQRPP--------------TTGPLLTPTGEVWPDCDPPCEGRVRYGGIGDSREGLWDAPEIKSAAER 418
Cdd:PHA03307   396 GRARRRDATGRFPAGRPRpspldagaasgafyARYPLLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAAR 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  419 YAVDPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPDQILAQFCQRAIHGPRGHGSFITGSVANPLPH 498
Cdd:PHA03307   476 YEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQKKFQAPRGSGSFITGSVARPVPH 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  499 VGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARPYLLGDHRTDcirsspgiadaipdappktpts 578
Cdd:PHA03307   556 IGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAADTGAG---------------------- 613

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  579 sdrvlmvsedilallqstlAGGTTRGTGDPTQIPTPGMGGENPRDLAETCTLACTAVFDSLIFHCGGVDRMPGLfeppsm 658
Cdd:PHA03307   614 -------------------AAAPAPAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGL------ 668

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  659 arsfpsvaKYPSPVCPPDALCAHPDVIEAVTARLYSLRDLVELSRIRGgeAPPERLSRDDLQLVVHSLLLVARTLAPLVR 738
Cdd:PHA03307   669 --------AFPRPACPPRALEACPARLESWLRELRDLRDAVYLARLRG--DLPVAGGREERVAAVRAVSLVARTVAPLVR 738

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  739 YNIDVARKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPT--------PRATASGNRAGGVTVEEISPPRSSNKMQQ 810
Cdd:PHA03307   739 YSPRRARARASAWDITDALFSNPSLVPAKLAEALALLEPAEPQrgagssppVRAEAAFRRPGRLRRSGPAADAASRTASK 818

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  811 RRDVHNPVAGG---CDPLQQSPSNFRPLSPHltrpqsSIRCKRKSEPLPRGHASGNLPIDAVRGEEMRAHPPTDAPPPTK 887
Cdd:PHA03307   819 RKSRSHTPDGGsesSGPARPPGAAARPPPAR------SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAA 892

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  888 KRAGPPRGP-----------LGPMPLGGPSPKGGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAIT 956
Cdd:PHA03307   893 AAAPPAGAPaprprpaprvkLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALA 972

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  957 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAHQNPNRDSRHTPAWSE 1036
Cdd:PHA03307   973 FDPEALAEIAARCGGPPPRSGSAFGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSP 1052

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1037 TKGGLSTLLAALGNRLLSPESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPED 1116
Cdd:PHA03307  1053 ERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPED 1132

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1117 WPATGPAVSHYHLYIRATVTPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTV 1196
Cdd:PHA03307  1133 WPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTV 1212

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1197 RTDAGDRTPVPMLPREYRQRVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALAST 1276
Cdd:PHA03307  1213 RTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAG 1292

                         1370      1380      1390      1400      1410
                   ....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1277 dPTRIPAVVRAFCRTALLAPDTEAPPLILTPADPQSAIIENIPGVTWDSG 1326
Cdd:PHA03307  1293 -PDELPAVVRAFCRAALLEPDPEAPPLVLPPSAAAEAAHARAPRVTWAKS 1341
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 909-1333 8.50e-158

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 482.96  E-value: 8.50e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  909 GGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAITFDPGALATIAARCTGPRRQEGTG--------- 979
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIAARVANALPGGGDYnsneiitsa 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  980 ----LGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAhQNPNRDSrhTPAWSETKGGLSTLLAALGNRLLSP 1055
Cdd:pfam03585   81 asraFGPPTATSKLRRRTAWMRQIPDPEDVRIVVLYSPLPGEDLF-CVPAPDT--PPKWSNKRGGLSFLLAALSNRLCLP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1056 ESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPEDWPATGPAVSHYHLYIRATV 1135
Cdd:pfam03585  158 KTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHTYMKCII 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1136 TPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTVRTDAGDRTPVPMLPREYRQ 1215
Cdd:pfam03585  238 SPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPREYRA 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1216 RVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALASTDPTRIPAVVRAFCRTALLA 1295
Cdd:pfam03585  318 AVLPVFDGCKDLARQSRGLGLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHVPTARNFCRSALLE 397

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1375633084 1296 PDTEAPPLILTP---------ADPQSAIIENIPGVTWDSGFGKQETV 1333
Cdd:pfam03585  398 PDPEARPLVLHIpegtcsalaEDMVASALPPCPRITWGQGFGHEEGG 444
Herpes_ICP4_N pfam03584
Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 ...
 388-547 7.43e-59

Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerization.


Pssm-ID: 367571 [Multi-domain]  Cd Length: 163  Bit Score: 199.67  E-value: 7.43e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  388 PPCEGRVRYGGIGDSREGLWDAPEIKSAAERYAVDPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPD 467
Cdd:pfam03584    1 PPPPGRVLYGGLGDSRPGLWGAPEVREARARFEASGAPAPVYVPELGDAAQQYAALVNLLYTPDAEPLGWLQNPRLNPGD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  468 QILAQFCQRAIHGPRGHGSFITGSVANPLPHVGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARP 547
Cdd:pfam03584   81 VALNQICQKISGAARNSGSAVTGSVARAVPHIGYAMAAGRALWALPHAAAAVAMSRRYDRAQKTFLLTSLRRAYAPLAFP 160
PHA03308 PHA03308
transcriptional regulator ICP4; Provisional
 388-1156 5.70e-15

transcriptional regulator ICP4; Provisional


Pssm-ID: 165563 [Multi-domain]  Cd Length: 1463  Bit Score: 80.62  E-value: 5.70e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  388 PPCEGRVRYGGigDSREGLWDAPEIKSAAERYAVDPGPVPVYVPEMGDSKKQYLALVR--LIYESGRDAMAWlQNSKMSG 465
Cdd:PHA03308   358 PPSRGQVYHGS--GYRQSLVDDPQVREAAAEFHANPKSASVYLEEYGMPVEQLERLVEefMVHPLSRVSYGY-GGPKLSP 434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  466 PDQILAQFCqrAIHGP-RGHGSFITGSVANPLPHVGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYwdi 544
Cdd:PHA03308   435 RDKRLCELC--ALRGPgSSEGGLSRSAVPTCLPHVAHAMRDGRVSLALPHLTELVRVCRRYDHPQKTYLLAALRRAF--- 509

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  545 aRPYLLGDHRTDcirssPGIADAIPDAPpktptssdrVLMVSEDILALLQSTLAGGTTRGTGDPTQIPTPGMGGEnprdl 624
Cdd:PHA03308   510 -VPFVFPGAAVD-----PTAASASGDHP---------VLVGARRIARATRELEAAAKEPPAATPEKLSSSALLRH----- 569

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  625 AETCTLACTAVFDSLIfhcgGVDRMPGLFEPpsmARSFPSVakYPSPVCPPDALCAHPDVIEAVTARLYslrdlvelSRI 704
Cdd:PHA03308   570 TRTCIVAAADLMAALT----AIDCPPVTINP---AKRRPDL--YQALSRAPKTVFTWERAMPYCAASLW--------SRL 632

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  705 RGGEAPPErlSRDDLQLVVHSLLLVARTLAPL----VRYNIDVArkrAPGWNLTRAVFAIPSRVAS--LMEEVAGTPDPH 778
Cdd:PHA03308   633 VIGSLPLP--STDDVTLLVEAMEAAVGVLGCSdegdVRPSIAYA---ASGWRMIATMLGDDSAPGSehVTDDCPADDDTH 707

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  779 TPTPRATASGNRAggvTVEEISPPRSSNKMQQRRDVHNPVAG-GCDP--LQQSPSN---------------FRPLSPHLT 840
Cdd:PHA03308   708 HHDRRKRRGGRRT---TCRYDLPPGTPDRAAHLLLYGSPGGGdGAEPsaAQESPANpwprappcdeqeplsVSPYGPEPD 784

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  841 RP-----QSSIRCKRKS-----EPLPRGHASGNLPidAVRGeemrahPPTDAPP--PTKKRAGPPRGPLGPMPLGGPSPk 908
Cdd:PHA03308   785 RPpdddfETRKGLKRKSsedhaDPIPEGNATKKTC--GLQG------LPDSLPPavPETDRDNPLLPPCPITPEGPPCP- 855

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  909 ggfrriPSGDCHTPR-PTDAVSSVYCPPEIVAELV-DHPLFPeawrsAITFDPGALATIAARCTGPR-RQEGTGLGGLVV 985
Cdd:PHA03308   856 ------PREEPQQPQePQEPQSPSFHISEIGEALFhSTPVSP-----TILFAPEGFIPNQGDVYRPHgKNLGVALSAGEP 924

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  986 SAPLRRASAWMTQIAD-----------------PEDVKVVVLYNPLP-HEHLAHQNP-NRDSR----HTPAW-------- 1034
Cdd:PHA03308   925 YVPAHRARPALERLANylrglssgpagsysatgPADWLPAFARDPVAlGEFCKRISPvNRGGRcvleERLSWtlrhpadk 1004

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084 1035 --------SETKGG----LSTLLAALGNRLLSPESHSWAGNWSG------PPDiRRLNAQGVLLLSTGDLAFAGCVEYLC 1096
Cdd:PHA03308  1005 iydliilvSERAPGefleRAYAYAALCGRACMPGGACWPESWTRgeypyiPPD-EKDPGRSVAILCTTDLGYAGAVEWML 1083

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1375633084 1097 LR-LGSARRRLIVFDTVDPEDWPA-TGPAVSHYH---LYIRATVTPTAYCAVRW--PALEDLSRAVL 1156
Cdd:PHA03308  1084 ERaLSTSGRACVVVDARDPGDEDSrSGPRIPTGRrgvVYARTSPPSHAYLVKLFtgPAAERLERGGL 1150
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 349-547 2.30e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 59.10  E-value: 2.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  349 GLLPRAERISERTSVfGIQRPPTTGPLLTPTGEVWPD----CDPPCEGRVRYGGIGdSREGLWDAPEIKSAAERYAVDPG 424
Cdd:PHA03309   590 GSLPELPDMCPRVAV-GIISHALAVDLSAPGGRITVDeallPKPPAADYVYYGKTG-YRPSMAAHPDVRRAAEEFSASDA 667

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  425 PVPVYVPEMGDSKKQYLALVR--LIYESGRDAMAWlQNSKMSGPDQILAQFC-----------QRAIHGPRGHGSFITG- 490
Cdd:PHA03309   668 AARVYVEEFGMAVEQHERLVAefMLQPLSRVSHSY-GGSRLNKTEKNLCKIClppdggddrdgGGKSRGGRGGGSKDASr 746

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1375633084  491 -SVANPLPHVGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARP 547
Cdd:PHA03309   747 tAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAPLVFP 804
PHA03247 PHA03247
large tegument protein UL36; Provisional
 655-1035 1.96e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  655 PPSMARSFPSVAKYPSPVCPPDAlcaHPDVIEAVTARLYSLRDLVELSRIRGGEAPPERLSRDDLQLVVHSLLLVARTLA 734
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPPP---ERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  735 PlvrynidvarKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPTPRATASGNRAGGVTVEEISPPRSSNkmqqrrdv 814
Cdd:PHA03247  2704 P----------PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG-------- 2765

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  815 hnpvaggcdPLQQSPSNFRPLSP--HLTRPQ-SSIRCKRKSEPLPRGHASGNLPIDA-VRGEEMRAHPPTDAPPPTKKRA 890
Cdd:PHA03247  2766 ---------PPAPAPPAAPAAGPprRLTRPAvASLSESRESLPSPWDPADPPAAVLApAAALPPAASPAGPLPPPTSAQP 2836

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375633084  891 GPPRGPLGPMPL-----GGPSPKGGFRRIPSGDCHTPRPTD---------AVSSVYCPPEIVAELVDHPLFPEAWRSAIT 956
Cdd:PHA03247  2837 TAPPPPPGPPPPslplgGSVAPGGDVRRRPPSRSPAAKPAAparppvrrlARPAVSRSTESFALPPDQPERPPQPQAPPP 2916

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1375633084  957 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAhqnPNRDSRHTPAWS 1035
Cdd:PHA03247  2917 PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP---QPAPSREAPASS 2992
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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