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Conserved domains on  [gi|1375632525|gb|AVW81366|]
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transcriptional regulator ICP4 [Felid alphaherpesvirus 1]

Protein Classification

PHA03307 family protein( domain architecture ID 11476204)

PHA03307 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-1324 0e+00

transcriptional regulator ICP4; Provisional


:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1328.26  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525   16 RFPQIDLFDLIEDFTDGREEFEFLGDTNSDvesrgRPQDLLYGSQGFLVSPPGDKDEVFFDFGKTPDDVNRVGN------ 89
Cdd:PHA03307     1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGD-----AADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTgpppgp 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525   90 -------------PTSGGTKTLTSPRPTRETITSGPTTKPPPPPTIHSAASPETPVPDIIEMLRRV--------QEDLGV 148
Cdd:PHA03307    76 gteapanesrstpTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVgspgpppaASPPAA 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  149 SESHGRSTSDTETCSHPSNALSITDSSAHSPSSVGVCDVTECDSLGARDYSRGRRSPISVGSMSPGPRRG---------- 218
Cdd:PHA03307   156 GASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGrsaaddagas 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  219 ---------------------RRSRSGSSSSSSSSSSSGSSSTGSRSSSSSSSSTSRSPSPPAPPNRELKPGTPSPPRPA 277
Cdd:PHA03307   236 ssdssssessgcgwgpenecpLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRAS 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  278 GEGSPITNDVIASITPQSNVVGSASTTPGATLTDGATLTDGPGDTTPKRRRRRGPLSRPP-------GSRLPRAVRGLLP 350
Cdd:PHA03307   316 SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPsspaasaGRPTRRRARAAVA 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  351 RAERISERTSVFGIQRPP--------------TTGPLLTPTGEVWPDCDPPCEGRVRYGGIGDSREGLWDAPEIKSAAER 416
Cdd:PHA03307   396 GRARRRDATGRFPAGRPRpspldagaasgafyARYPLLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAAR 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  417 YAADPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPDQILAQFCQRAIHGPRGHGSFITGSVANPLPH 496
Cdd:PHA03307   476 YEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQKKFQAPRGSGSFITGSVARPVPH 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  497 VGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARPYLLGDHRTDcirsspgiadaipdappktpts 576
Cdd:PHA03307   556 IGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAADTGAG---------------------- 613

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  577 sdrvlmvsedilallqstlAGGTTRGTGDPTQIPTPGMGGENPRDLAETCTLACTAVFDSLIFHCGGVDRMPGLfeppsm 656
Cdd:PHA03307   614 -------------------AAAPAPAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGL------ 668

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  657 arsfpsvaKYPSPVCPPDALCAHPDVIEAVTARLYSLRDLVELSRIRGgeAPPERLSRDDLQLVVHSLLLVARTLAPLVR 736
Cdd:PHA03307   669 --------AFPRPACPPRALEACPARLESWLRELRDLRDAVYLARLRG--DLPVAGGREERVAAVRAVSLVARTVAPLVR 738

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  737 YNIDVARKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPT--------PRATASGNRAGGVTVEEISPPRSSNKMQQ 808
Cdd:PHA03307   739 YSPRRARARASAWDITDALFSNPSLVPAKLAEALALLEPAEPQrgagssppVRAEAAFRRPGRLRRSGPAADAASRTASK 818

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  809 RRDVHNPVAGG---CDPLQQSPSNFRPLSPHltrpqsSIRCKRKSEPLPRGHASGNLPIDAVRGEEMRAHPPTDAPPPTK 885
Cdd:PHA03307   819 RKSRSHTPDGGsesSGPARPPGAAARPPPAR------SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAA 892

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  886 KRAGPPRGP-----------LGPMPLGGPSPKGGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAIT 954
Cdd:PHA03307   893 AAAPPAGAPaprprpaprvkLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALA 972

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  955 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAHQNPNRDSRHTPAWSE 1034
Cdd:PHA03307   973 FDPEALAEIAARCGGPPPRSGSAFGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSP 1052

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1035 TKGGLSTLLAALGNRLLSPESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPED 1114
Cdd:PHA03307  1053 ERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPED 1132

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1115 WPATGPAVSHYHLYIRATVTPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTV 1194
Cdd:PHA03307  1133 WPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTV 1212

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1195 RTDAGDRTPVPMLPREYRQRVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALAST 1274
Cdd:PHA03307  1213 RTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAG 1292

                         1370      1380      1390      1400      1410
                   ....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1275 dPTRIPAVVRAFCRTALLAPDTEAPPLILTPADPQSAIIENIPGVTWDSG 1324
Cdd:PHA03307  1293 -PDELPAVVRAFCRAALLEPDPEAPPLVLPPSAAAEAAHARAPRVTWAKS 1341
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-1324 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1328.26  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525   16 RFPQIDLFDLIEDFTDGREEFEFLGDTNSDvesrgRPQDLLYGSQGFLVSPPGDKDEVFFDFGKTPDDVNRVGN------ 89
Cdd:PHA03307     1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGD-----AADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTgpppgp 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525   90 -------------PTSGGTKTLTSPRPTRETITSGPTTKPPPPPTIHSAASPETPVPDIIEMLRRV--------QEDLGV 148
Cdd:PHA03307    76 gteapanesrstpTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVgspgpppaASPPAA 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  149 SESHGRSTSDTETCSHPSNALSITDSSAHSPSSVGVCDVTECDSLGARDYSRGRRSPISVGSMSPGPRRG---------- 218
Cdd:PHA03307   156 GASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGrsaaddagas 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  219 ---------------------RRSRSGSSSSSSSSSSSGSSSTGSRSSSSSSSSTSRSPSPPAPPNRELKPGTPSPPRPA 277
Cdd:PHA03307   236 ssdssssessgcgwgpenecpLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRAS 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  278 GEGSPITNDVIASITPQSNVVGSASTTPGATLTDGATLTDGPGDTTPKRRRRRGPLSRPP-------GSRLPRAVRGLLP 350
Cdd:PHA03307   316 SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPsspaasaGRPTRRRARAAVA 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  351 RAERISERTSVFGIQRPP--------------TTGPLLTPTGEVWPDCDPPCEGRVRYGGIGDSREGLWDAPEIKSAAER 416
Cdd:PHA03307   396 GRARRRDATGRFPAGRPRpspldagaasgafyARYPLLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAAR 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  417 YAADPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPDQILAQFCQRAIHGPRGHGSFITGSVANPLPH 496
Cdd:PHA03307   476 YEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQKKFQAPRGSGSFITGSVARPVPH 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  497 VGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARPYLLGDHRTDcirsspgiadaipdappktpts 576
Cdd:PHA03307   556 IGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAADTGAG---------------------- 613

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  577 sdrvlmvsedilallqstlAGGTTRGTGDPTQIPTPGMGGENPRDLAETCTLACTAVFDSLIFHCGGVDRMPGLfeppsm 656
Cdd:PHA03307   614 -------------------AAAPAPAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGL------ 668

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  657 arsfpsvaKYPSPVCPPDALCAHPDVIEAVTARLYSLRDLVELSRIRGgeAPPERLSRDDLQLVVHSLLLVARTLAPLVR 736
Cdd:PHA03307   669 --------AFPRPACPPRALEACPARLESWLRELRDLRDAVYLARLRG--DLPVAGGREERVAAVRAVSLVARTVAPLVR 738

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  737 YNIDVARKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPT--------PRATASGNRAGGVTVEEISPPRSSNKMQQ 808
Cdd:PHA03307   739 YSPRRARARASAWDITDALFSNPSLVPAKLAEALALLEPAEPQrgagssppVRAEAAFRRPGRLRRSGPAADAASRTASK 818

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  809 RRDVHNPVAGG---CDPLQQSPSNFRPLSPHltrpqsSIRCKRKSEPLPRGHASGNLPIDAVRGEEMRAHPPTDAPPPTK 885
Cdd:PHA03307   819 RKSRSHTPDGGsesSGPARPPGAAARPPPAR------SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAA 892

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  886 KRAGPPRGP-----------LGPMPLGGPSPKGGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAIT 954
Cdd:PHA03307   893 AAAPPAGAPaprprpaprvkLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALA 972

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  955 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAHQNPNRDSRHTPAWSE 1034
Cdd:PHA03307   973 FDPEALAEIAARCGGPPPRSGSAFGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSP 1052

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1035 TKGGLSTLLAALGNRLLSPESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPED 1114
Cdd:PHA03307  1053 ERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPED 1132

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1115 WPATGPAVSHYHLYIRATVTPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTV 1194
Cdd:PHA03307  1133 WPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTV 1212

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1195 RTDAGDRTPVPMLPREYRQRVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALAST 1274
Cdd:PHA03307  1213 RTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAG 1292

                         1370      1380      1390      1400      1410
                   ....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1275 dPTRIPAVVRAFCRTALLAPDTEAPPLILTPADPQSAIIENIPGVTWDSG 1324
Cdd:PHA03307  1293 -PDELPAVVRAFCRAALLEPDPEAPPLVLPPSAAAEAAHARAPRVTWAKS 1341
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 907-1331 8.18e-158

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 482.96  E-value: 8.18e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  907 GGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAITFDPGALATIAARCTGPRRQEGTG--------- 977
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIAARVANALPGGGDYnsneiitsa 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  978 ----LGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAhQNPNRDSrhTPAWSETKGGLSTLLAALGNRLLSP 1053
Cdd:pfam03585   81 asraFGPPTATSKLRRRTAWMRQIPDPEDVRIVVLYSPLPGEDLF-CVPAPDT--PPKWSNKRGGLSFLLAALSNRLCLP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1054 ESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPEDWPATGPAVSHYHLYIRATV 1133
Cdd:pfam03585  158 KTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHTYMKCII 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1134 TPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTVRTDAGDRTPVPMLPREYRQ 1213
Cdd:pfam03585  238 SPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPREYRA 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1214 RVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALASTDPTRIPAVVRAFCRTALLA 1293
Cdd:pfam03585  318 AVLPVFDGCKDLARQSRGLGLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHVPTARNFCRSALLE 397

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1375632525 1294 PDTEAPPLILTP---------ADPQSAIIENIPGVTWDSGFGKQETV 1331
Cdd:pfam03585  398 PDPEARPLVLHIpegtcsalaEDMVASALPPCPRITWGQGFGHEEGG 444
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-1324 0e+00

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 1328.26  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525   16 RFPQIDLFDLIEDFTDGREEFEFLGDTNSDvesrgRPQDLLYGSQGFLVSPPGDKDEVFFDFGKTPDDVNRVGN------ 89
Cdd:PHA03307     1 SDNAPDLYDLIEAAAEGGEFFPRPPATPGD-----AADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTgpppgp 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525   90 -------------PTSGGTKTLTSPRPTRETITSGPTTKPPPPPTIHSAASPETPVPDIIEMLRRV--------QEDLGV 148
Cdd:PHA03307    76 gteapanesrstpTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVgspgpppaASPPAA 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  149 SESHGRSTSDTETCSHPSNALSITDSSAHSPSSVGVCDVTECDSLGARDYSRGRRSPISVGSMSPGPRRG---------- 218
Cdd:PHA03307   156 GASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGrsaaddagas 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  219 ---------------------RRSRSGSSSSSSSSSSSGSSSTGSRSSSSSSSSTSRSPSPPAPPNRELKPGTPSPPRPA 277
Cdd:PHA03307   236 ssdssssessgcgwgpenecpLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRAS 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  278 GEGSPITNDVIASITPQSNVVGSASTTPGATLTDGATLTDGPGDTTPKRRRRRGPLSRPP-------GSRLPRAVRGLLP 350
Cdd:PHA03307   316 SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPsspaasaGRPTRRRARAAVA 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  351 RAERISERTSVFGIQRPP--------------TTGPLLTPTGEVWPDCDPPCEGRVRYGGIGDSREGLWDAPEIKSAAER 416
Cdd:PHA03307   396 GRARRRDATGRFPAGRPRpspldagaasgafyARYPLLTPSGEPWPGSPPPPPGRVRYGGLGDSRPGLWDAPEVREAAAR 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  417 YAADPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPDQILAQFCQRAIHGPRGHGSFITGSVANPLPH 496
Cdd:PHA03307   476 YEASPGPVPVYVPEMGDSAKQYAALVRLLYTPDREAMGWLQNPKLTGPDQALDQFCQKKFQAPRGSGSFITGSVARPVPH 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  497 VGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARPYLLGDHRTDcirsspgiadaipdappktpts 576
Cdd:PHA03307   556 IGDAMAAGNALWALPHAAAAVAMSRRYDRAQKGFLLQSLRRAYAPMAYPENAADTGAG---------------------- 613

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  577 sdrvlmvsedilallqstlAGGTTRGTGDPTQIPTPGMGGENPRDLAETCTLACTAVFDSLIFHCGGVDRMPGLfeppsm 656
Cdd:PHA03307   614 -------------------AAAPAPAAPRPDAAAAGGASARPLRELADACVLACRAVLEALLEGPDGLSAVPGL------ 668

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  657 arsfpsvaKYPSPVCPPDALCAHPDVIEAVTARLYSLRDLVELSRIRGgeAPPERLSRDDLQLVVHSLLLVARTLAPLVR 736
Cdd:PHA03307   669 --------AFPRPACPPRALEACPARLESWLRELRDLRDAVYLARLRG--DLPVAGGREERVAAVRAVSLVARTVAPLVR 738

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  737 YNIDVARKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPT--------PRATASGNRAGGVTVEEISPPRSSNKMQQ 808
Cdd:PHA03307   739 YSPRRARARASAWDITDALFSNPSLVPAKLAEALALLEPAEPQrgagssppVRAEAAFRRPGRLRRSGPAADAASRTASK 818

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  809 RRDVHNPVAGG---CDPLQQSPSNFRPLSPHltrpqsSIRCKRKSEPLPRGHASGNLPIDAVRGEEMRAHPPTDAPPPTK 885
Cdd:PHA03307   819 RKSRSHTPDGGsesSGPARPPGAAARPPPAR------SSESSKSKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAA 892

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  886 KRAGPPRGP-----------LGPMPLGGPSPKGGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAIT 954
Cdd:PHA03307   893 AAAPPAGAPaprprpaprvkLGPMPPGGPDPRGGFRRVPPGDLHTPAPSAAALAAYCPPEVVAELVDHPLFPEPWRPALA 972

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  955 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAHQNPNRDSRHTPAWSE 1034
Cdd:PHA03307   973 FDPEALAEIAARCGGPPPRSGSAFGPLRASGPLRRRAAWMRQIPDPEDVRVVVLYSPLPGEHLFGVPAPDASPGGPAWSP 1052

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1035 TKGGLSTLLAALGNRLLSPESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPED 1114
Cdd:PHA03307  1053 ERGGLSFLLAALGNRLCLPDSHAWAGNWTGAPDVSALNAQGVLLLSTRDLAFAGAVEYLCLRLGSARRRLIVLDTVDPED 1132

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1115 WPATGPAVSHYHLYIRATVTPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTV 1194
Cdd:PHA03307  1133 WPADGPAVSQYHVYLRCAVLPRAQCAVRWPAARDLARAVLTSSRVFGPGLFARVEAAFARLYPDAPPLRLCRGANVRYTV 1212

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1195 RTDAGDRTPVPMLPREYRQRVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALAST 1274
Cdd:PHA03307  1213 RTRLGPRTRVPLPPREYRQAVLPALDGCKDMAAQAEGLGLGAPDFLEGEAHSHRAANRWGLGAPLRPVYLAEGRRAAIAG 1292

                         1370      1380      1390      1400      1410
                   ....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1275 dPTRIPAVVRAFCRTALLAPDTEAPPLILTPADPQSAIIENIPGVTWDSG 1324
Cdd:PHA03307  1293 -PDELPAVVRAFCRAALLEPDPEAPPLVLPPSAAAEAAHARAPRVTWAKS 1341
Herpes_ICP4_C pfam03585
Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 ...
 907-1331 8.18e-158

Herpesvirus ICP4-like protein C-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the C-terminal region that probably acts as an enhancer for the N-terminal region.


Pssm-ID: 281570  Cd Length: 444  Bit Score: 482.96  E-value: 8.18e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  907 GGFRRIPSGDCHTPRPTDAVSSVYCPPEIVAELVDHPLFPEAWRSAITFDPGALATIAARCTGPRRQEGTG--------- 977
Cdd:pfam03585    1 GGFRRFPVGTVHTQTPPQSALNAYCPPGAFAELVDFPLFPEPWRPALRFDPEALADIAARVANALPGGGDYnsneiitsa 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  978 ----LGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAhQNPNRDSrhTPAWSETKGGLSTLLAALGNRLLSP 1053
Cdd:pfam03585   81 asraFGPPTATSKLRRRTAWMRQIPDPEDVRIVVLYSPLPGEDLF-CVPAPDT--PPKWSNKRGGLSFLLAALSNRLCLP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1054 ESHSWAGNWSGPPDIRRLNAQGVLLLSTGDLAFAGCVEYLCLRLGSARRRLIVFDTVDPEDWPATGPAVSHYHLYIRATV 1133
Cdd:pfam03585  158 KTSAWAGNWTGAPDVSALTAMGVLLLSTRDLAFAGAVEYLGRQCMKRKRRLIVMDTVEDRYWPPDGPAISEEHTYMKCII 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1134 TPTAYCAVRWPALEDLSRAVLTSSAIFGPGSFARVEAAFERLYPNCDGLRLCASGNVGYTVRTDAGDRTPVPMLPREYRQ 1213
Cdd:pfam03585  238 SPRSQCCVRWPGLLDLGRTVIASRRVFGPLTFARLEQAYAELYPEDSPLNLCRGGNVRYTVETRLGPVTCVPTSPREYRA 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1214 RVLPAYDGCKDMEAQSAGLKLGEPDFVDGAAHSHRACNRWGLGAPLRPVYLATGRRALASTDPTRIPAVVRAFCRTALLA 1293
Cdd:pfam03585  318 AVLPVFDGCKDLARQSRGLGLGAPDFLCEEAHSHRAARRWGLGAPLRPVYVIEGRMNAIAGPSFLHVPTARNFCRSALLE 397

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 1375632525 1294 PDTEAPPLILTP---------ADPQSAIIENIPGVTWDSGFGKQETV 1331
Cdd:pfam03585  398 PDPEARPLVLHIpegtcsalaEDMVASALPPCPRITWGQGFGHEEGG 444
Herpes_ICP4_N pfam03584
Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 ...
 386-545 1.44e-59

Herpesvirus ICP4-like protein N-terminal region; The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and ORF-P that have high-affinity a ICP4 binding site that spans the transcription initiation site. ICP4 proteins have two highly conserved regions, this family contains the N-terminal region that contains sites for DNA binding and homodimerization.


Pssm-ID: 367571 [Multi-domain]  Cd Length: 163  Bit Score: 201.98  E-value: 1.44e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  386 PPCEGRVRYGGIGDSREGLWDAPEIKSAAERYAADPGPVPVYVPEMGDSKKQYLALVRLIYESGRDAMAWLQNSKMSGPD 465
Cdd:pfam03584    1 PPPPGRVLYGGLGDSRPGLWGAPEVREARARFEASGAPAPVYVPELGDAAQQYAALVNLLYTPDAEPLGWLQNPRLNPGD 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  466 QILAQFCQRAIHGPRGHGSFITGSVANPLPHVGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARP 545
Cdd:pfam03584   81 VALNQICQKISGAARNSGSAVTGSVARAVPHIGYAMAAGRALWALPHAAAAVAMSRRYDRAQKTFLLTSLRRAYAPLAFP 160
PHA03308 PHA03308
transcriptional regulator ICP4; Provisional
 386-1154 1.82e-15

transcriptional regulator ICP4; Provisional


Pssm-ID: 165563 [Multi-domain]  Cd Length: 1463  Bit Score: 82.16  E-value: 1.82e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  386 PPCEGRVRYGGigDSREGLWDAPEIKSAAERYAADPGPVPVYVPEMGDSKKQYLALVR--LIYESGRDAMAWlQNSKMSG 463
Cdd:PHA03308   358 PPSRGQVYHGS--GYRQSLVDDPQVREAAAEFHANPKSASVYLEEYGMPVEQLERLVEefMVHPLSRVSYGY-GGPKLSP 434

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  464 PDQILAQFCqrAIHGP-RGHGSFITGSVANPLPHVGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYwdi 542
Cdd:PHA03308   435 RDKRLCELC--ALRGPgSSEGGLSRSAVPTCLPHVAHAMRDGRVSLALPHLTELVRVCRRYDHPQKTYLLAALRRAF--- 509

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  543 aRPYLLGDHRTDcirssPGIADAIPDAPpktptssdrVLMVSEDILALLQSTLAGGTTRGTGDPTQIPTPGMGGEnprdl 622
Cdd:PHA03308   510 -VPFVFPGAAVD-----PTAASASGDHP---------VLVGARRIARATRELEAAAKEPPAATPEKLSSSALLRH----- 569

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  623 AETCTLACTAVFDSLIfhcgGVDRMPGLFEPpsmARSFPSVakYPSPVCPPDALCAHPDVIEAVTARLYslrdlvelSRI 702
Cdd:PHA03308   570 TRTCIVAAADLMAALT----AIDCPPVTINP---AKRRPDL--YQALSRAPKTVFTWERAMPYCAASLW--------SRL 632

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  703 RGGEAPPErlSRDDLQLVVHSLLLVARTLAPL----VRYNIDVArkrAPGWNLTRAVFAIPSRVAS--LMEEVAGTPDPH 776
Cdd:PHA03308   633 VIGSLPLP--STDDVTLLVEAMEAAVGVLGCSdegdVRPSIAYA---ASGWRMIATMLGDDSAPGSehVTDDCPADDDTH 707

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  777 TPTPRATASGNRAggvTVEEISPPRSSNKMQQRRDVHNPVAG-GCDP--LQQSPSN---------------FRPLSPHLT 838
Cdd:PHA03308   708 HHDRRKRRGGRRT---TCRYDLPPGTPDRAAHLLLYGSPGGGdGAEPsaAQESPANpwprappcdeqeplsVSPYGPEPD 784

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  839 RP-----QSSIRCKRKS-----EPLPRGHASGNLPidAVRGeemrahPPTDAPP--PTKKRAGPPRGPLGPMPLGGPSPk 906
Cdd:PHA03308   785 RPpdddfETRKGLKRKSsedhaDPIPEGNATKKTC--GLQG------LPDSLPPavPETDRDNPLLPPCPITPEGPPCP- 855

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  907 ggfrriPSGDCHTPR-PTDAVSSVYCPPEIVAELV-DHPLFPeawrsAITFDPGALATIAARCTGPR-RQEGTGLGGLVV 983
Cdd:PHA03308   856 ------PREEPQQPQePQEPQSPSFHISEIGEALFhSTPVSP-----TILFAPEGFIPNQGDVYRPHgKNLGVALSAGEP 924

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  984 SAPLRRASAWMTQIAD-----------------PEDVKVVVLYNPLP-HEHLAHQNP-NRDSR----HTPAW-------- 1032
Cdd:PHA03308   925 YVPAHRARPALERLANylrglssgpagsysatgPADWLPAFARDPVAlGEFCKRISPvNRGGRcvleERLSWtlrhpadk 1004

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525 1033 --------SETKGG----LSTLLAALGNRLLSPESHSWAGNWSG------PPDiRRLNAQGVLLLSTGDLAFAGCVEYLC 1094
Cdd:PHA03308  1005 iydliilvSERAPGefleRAYAYAALCGRACMPGGACWPESWTRgeypyiPPD-EKDPGRSVAILCTTDLGYAGAVEWML 1083

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1375632525 1095 LR-LGSARRRLIVFDTVDPEDWPA-TGPAVSHYH---LYIRATVTPTAYCAVRW--PALEDLSRAVL 1154
Cdd:PHA03308  1084 ERaLSTSGRACVVVDARDPGDEDSrSGPRIPTGRrgvVYARTSPPSHAYLVKLFtgPAAERLERGGL 1150
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 347-545 7.79e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 60.64  E-value: 7.79e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  347 GLLPRAERISERTSVfGIQRPPTTGPLLTPTGEVWPD----CDPPCEGRVRYGGIGdSREGLWDAPEIKSAAERYAADPG 422
Cdd:PHA03309   590 GSLPELPDMCPRVAV-GIISHALAVDLSAPGGRITVDeallPKPPAADYVYYGKTG-YRPSMAAHPDVRRAAEEFSASDA 667

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  423 PVPVYVPEMGDSKKQYLALVR--LIYESGRDAMAWlQNSKMSGPDQILAQFC-----------QRAIHGPRGHGSFITG- 488
Cdd:PHA03309   668 AARVYVEEFGMAVEQHERLVAefMLQPLSRVSHSY-GGSRLNKTEKNLCKIClppdggddrdgGGKSRGGRGGGSKDASr 746

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1375632525  489 -SVANPLPHVGDAMATMDPLLALPHVTAAVAMSRRYDRTQKTYMLQSLRRAYWDIARP 545
Cdd:PHA03309   747 tAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAPLVFP 804
PHA03247 PHA03247
large tegument protein UL36; Provisional
 653-1033 1.95e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  653 PPSMARSFPSVAKYPSPVCPPDAlcaHPDVIEAVTARLYSLRDLVELSRIRGGEAPPERLSRDDLQLVVHSLLLVARTLA 732
Cdd:PHA03247  2627 PPPSPSPAANEPDPHPPPTVPPP---ERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  733 PlvrynidvarKRAPGWNLTRAVFAIPSRVASLMEEVAGTPDPHTPTPRATASGNRAGGVTVEEISPPRSSNkmqqrrdv 812
Cdd:PHA03247  2704 P----------PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG-------- 2765

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  813 hnpvaggcdPLQQSPSNFRPLSP--HLTRPQ-SSIRCKRKSEPLPRGHASGNLPIDA-VRGEEMRAHPPTDAPPPTKKRA 888
Cdd:PHA03247  2766 ---------PPAPAPPAAPAAGPprRLTRPAvASLSESRESLPSPWDPADPPAAVLApAAALPPAASPAGPLPPPTSAQP 2836

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375632525  889 GPPRGPLGPMPL-----GGPSPKGGFRRIPSGDCHTPRPTD---------AVSSVYCPPEIVAELVDHPLFPEAWRSAIT 954
Cdd:PHA03247  2837 TAPPPPPGPPPPslplgGSVAPGGDVRRRPPSRSPAAKPAAparppvrrlARPAVSRSTESFALPPDQPERPPQPQAPPP 2916

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1375632525  955 FDPGALATIAARCTGPRRQEGTGLGGLVVSAPLRRASAWMTQIADPEDVKVVVLYNPLPHEHLAhqnPNRDSRHTPAWS 1033
Cdd:PHA03247  2917 PQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVP---QPAPSREAPASS 2992
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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