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Conserved domains on  [gi|1375544102|gb|AVW08933|]
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MFS transporter [Lactiplantibacillus plantarum]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 16-407 6.99e-25

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17316:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 353  Bit Score: 104.61  E-value: 6.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  16 IIVAGLASYMDAALLVSLGVALPIWTKY--LALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGS 93
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  94 FIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSPA--A 171
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGwrI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 172 LFGWIGLVAIINWCVRVFskrfkqietdlvdhehvdcasngqsvkkyrlgqllrtggllvpMILLTVFYLFWNLPANTWG 251
Cdd:cd17316   161 LFLIGALPALLALLLRRR-------------------------------------------TLLLILLWFFISFGYYGLT 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 252 SFVNYFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFY 331
Cdd:cd17316   198 TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI 277

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375544102 332 SGSTVLCGEALYKIWSQTFYPVDARATMTGFSYGLVRVLTAAFSLVTPTLMGYSPQLLLWIMVGCTVLFGACAVII 407
Cdd:cd17316   278 LSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
 
Name Accession Description Interval E-value
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 16-407 6.99e-25

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 104.61  E-value: 6.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  16 IIVAGLASYMDAALLVSLGVALPIWTKY--LALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGS 93
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  94 FIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSPA--A 171
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGwrI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 172 LFGWIGLVAIINWCVRVFskrfkqietdlvdhehvdcasngqsvkkyrlgqllrtggllvpMILLTVFYLFWNLPANTWG 251
Cdd:cd17316   161 LFLIGALPALLALLLRRR-------------------------------------------TLLLILLWFFISFGYYGLT 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 252 SFVNYFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFY 331
Cdd:cd17316   198 TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI 277

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375544102 332 SGSTVLCGEALYKIWSQTFYPVDARATMTGFSYGLVRVLTAAFSLVTPTLMGYSPQLLLWIMVGCTVLFGACAVII 407
Cdd:cd17316   278 LSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-373 2.16e-22

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 97.35  E-value: 2.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   9 SKANVLLIIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFF 88
Cdd:COG2814     5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  89 VAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSgmGS 168
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL--FG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 169 PAALFGWIGLVAIINWCVRVFSKRfkqietdlvdhehvDCASNGQSVKKYRLGQLLRTGGLLVPMILLTVFYLFWnlpaN 248
Cdd:COG2814   163 WRWVFLVNAVLALLALLLLLRLLP--------------ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGF----F 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 249 TWGSFVNYFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVY 328
Cdd:COG2814   225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF 304

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1375544102 329 IFysGSTVLCGEALYKIWSQTFYPVDARATMTGFSYGLVRVLTAA 373
Cdd:COG2814   305 LL--GFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 4-369 3.37e-14

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 73.93  E-value: 3.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   4 EKVKLSKANVLLIIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFN 83
Cdd:TIGR00895   7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  84 ADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFI-GFITA 162
Cdd:TIGR00895  87 WSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLaGWLIP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 163 NSGMGSPAALFGWIGLVAI----------INWCVRVFSKRFKQIETDLVDHEHVDCAS----NGQSVKKYRLGQ-LLRTG 227
Cdd:TIGR00895 167 VFGWRSLFYVGGIAPLLLLlllmrflpesIDFLVSKRPETVRRIVNAIAPQMQAEAQSalpeQKSTQGTKRSVFkALFQG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 228 GLLVPMILLTVFYLFWNLPANTWGSFVNYFLVTVdGRTQAYSTIVALIANIVCLLVNLIYLKVSDtRYRYRVMYLG-IAV 306
Cdd:TIGR00895 247 KTARITVLLWLLYFMLLVGVYFLTNWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLAD-RLGPRVTALLlLLG 324

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1375544102 307 ALLSFVTAGIFSDDWQIFTVVYIFysGSTVLCGEALYKIWSQTFYPVDARATMTGFSYGLVRV 369
Cdd:TIGR00895 325 AVFAVLVGSTLFSPTLLLLLGAIA--GFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRL 385
MFS_1 pfam07690
Major Facilitator Superfamily;
16-362 2.80e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 64.36  E-value: 2.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  16 IIVAGLASYMDAALLVSlgVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFI 95
Cdd:pfam07690   1 LFLAAFLAALGRSLLGP--ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  96 IAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFI-GFITANSGMGSPAALFG 174
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLgGLLASLFGWRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 175 WIGLVAIINWCVRVfsKRFKQIETDLVDHEHVDCASNGQSVKKYRLGQLLRTGGLLVPMILLTVFYLFwnlpantwgsfv 254
Cdd:pfam07690 159 ILSLLAAVLLLLPR--PPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP------------ 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 255 nyFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFY-SG 333
Cdd:pfam07690 225 --LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLlLG 302

                         330       340
                  ....*....|....*....|....*....
gi 1375544102 334 STVLCGEALYKIWSQTFYPVDARATMTGF 362
Cdd:pfam07690 303 FGFGLVFPALNALVSDLAPKEERGTASGL 331
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 30-141 9.13e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 47.65  E-value: 9.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  30 LVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGV 109
Cdd:PRK11551   31 LQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVAR 110

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1375544102 110 VIAGLASGADLPTSLAVISERMSSKVYGRAIS 141
Cdd:PRK11551  111 LLTGVGLGGALPNLIALTSEAVGPRLRGTAVS 142
 
Name Accession Description Interval E-value
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 16-407 6.99e-25

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 104.61  E-value: 6.99e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  16 IIVAGLASYMDAALLVSLGVALPIWTKY--LALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGS 93
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  94 FIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSPA--A 171
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGwrI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 172 LFGWIGLVAIINWCVRVFskrfkqietdlvdhehvdcasngqsvkkyrlgqllrtggllvpMILLTVFYLFWNLPANTWG 251
Cdd:cd17316   161 LFLIGALPALLALLLRRR-------------------------------------------TLLLILLWFFISFGYYGLT 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 252 SFVNYFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFY 331
Cdd:cd17316   198 TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI 277

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375544102 332 SGSTVLCGEALYKIWSQTFYPVDARATMTGFSYGLVRVLTAAFSLVTPTLMGYSPQLLLWIMVGCTVLFGACAVII 407
Cdd:cd17316   278 LSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-373 2.16e-22

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 97.35  E-value: 2.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   9 SKANVLLIIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFF 88
Cdd:COG2814     5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  89 VAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSgmGS 168
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL--FG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 169 PAALFGWIGLVAIINWCVRVFSKRfkqietdlvdhehvDCASNGQSVKKYRLGQLLRTGGLLVPMILLTVFYLFWnlpaN 248
Cdd:COG2814   163 WRWVFLVNAVLALLALLLLLRLLP--------------ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGF----F 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 249 TWGSFVNYFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVY 328
Cdd:COG2814   225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALF 304

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1375544102 329 IFysGSTVLCGEALYKIWSQTFYPVDARATMTGFSYGLVRVLTAA 373
Cdd:COG2814   305 LL--GFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
13-409 2.89e-21

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 94.55  E-value: 2.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  13 VLLIIVAGLASYMDaalLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIG 92
Cdd:COG2271    12 LALLFLAYFLNYLD---RSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  93 SFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFI-GFITANSGMGSPAA 171
Cdd:COG2271    89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLlGWLLAAFGWRAAFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 172 LFGWIGLVAiinwcvrvfskrfkqietdlvdhehvdcasngqsvkkyrlgqllrtggLLVPMILLTVFYLFWNLPANTWG 251
Cdd:COG2271   169 ILGLPGLLL------------------------------------------------ALLRFWLLALAYFLVYFALYGFL 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 252 SFVNYFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSD--TRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYI 329
Cdd:COG2271   201 TWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDrlGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFL 280

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 330 FysGSTVLCGEALYKIWSQTFYPVDARATMTGFSYGLVRVLTAAFSLVTPTLMGYSPQLLLWIMVGCTVLFGACAVIIVA 409
Cdd:COG2271   281 A--GFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-182 1.23e-17

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 82.94  E-value: 1.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   1 MVDEKVKLSKANVLLIIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVA 80
Cdd:COG0477     1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  81 VFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIG-F 159
Cdd:COG0477    81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGgL 160

                         170       180
                  ....*....|....*....|...
gi 1375544102 160 ITANSGMGSPAALFGWIGLVAII 182
Cdd:COG0477   161 LVAALGWRWIFLINAPLGLLALV 183
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 37-411 9.97e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 78.00  E-value: 9.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  37 LPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLAS 116
Cdd:cd17325    19 LPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLAS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 117 GADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIG-FITANSGMGSPAALFGWIGLVAIInWCVRVFSKRFKQ 195
Cdd:cd17325    99 AAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGgLLADALGYRAPFLVCAALALLALV-LALLLLPEPRPP 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 196 IETDLVDHEHvdcasngqsvKKYRLGQLLRTGGLLVPMILLTVFYLFWNLpantWGSFVNYFLVTVDGRTQAYSTIVALI 275
Cdd:cd17325   178 PNKRAVSAAR----------LRSGLRLLLRDRRLLALFLAIFVLAFAFGA----LEPFLPLYAAELGGLSPAQIGLLFGA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 276 ANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFYsgstvlCGEALYKIWSQTFYPVDA 355
Cdd:cd17325   244 QGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLG------LGLGLVFPATLALLADIV 317

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1375544102 356 RATMTGFSYGLVRVLTAAFSLVTPTLMG--YSPQLLLWIMVGCTVLFGACAVIIVAII 411
Cdd:cd17325   318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGflYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 19-405 1.62e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 74.39  E-value: 1.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  19 AGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAI 98
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  99 AQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSPAALFGWIGL 178
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 179 VAIINWCVRVFskrfkqietdLVDHEHVDCASNGQSVKKYRLGQLLRTGGLLVPMILLTVFYLFWNLPANTWGSFVNYFL 258
Cdd:cd06174   161 LALLAAILLLL----------VVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 259 VTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFYSGSTVLC 338
Cdd:cd06174   231 LDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGL 310

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1375544102 339 GeALYKIWSQTFYPVDARATMTGFSYGLVRVLTAAFSLVTPTL--MGYSPQLLLWIMVGCTVLFGACAV 405
Cdd:cd06174   311 L-PLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlaATFGLTGAFLVLAVLLLLAAILLL 378
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 4-369 3.37e-14

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 73.93  E-value: 3.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   4 EKVKLSKANVLLIIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFN 83
Cdd:TIGR00895   7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  84 ADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFI-GFITA 162
Cdd:TIGR00895  87 WSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLaGWLIP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 163 NSGMGSPAALFGWIGLVAI----------INWCVRVFSKRFKQIETDLVDHEHVDCAS----NGQSVKKYRLGQ-LLRTG 227
Cdd:TIGR00895 167 VFGWRSLFYVGGIAPLLLLlllmrflpesIDFLVSKRPETVRRIVNAIAPQMQAEAQSalpeQKSTQGTKRSVFkALFQG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 228 GLLVPMILLTVFYLFWNLPANTWGSFVNYFLVTVdGRTQAYSTIVALIANIVCLLVNLIYLKVSDtRYRYRVMYLG-IAV 306
Cdd:TIGR00895 247 KTARITVLLWLLYFMLLVGVYFLTNWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLAD-RLGPRVTALLlLLG 324

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1375544102 307 ALLSFVTAGIFSDDWQIFTVVYIFysGSTVLCGEALYKIWSQTFYPVDARATMTGFSYGLVRV 369
Cdd:TIGR00895 325 AVFAVLVGSTLFSPTLLLLLGAIA--GFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRL 385
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 36-175 3.48e-14

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 73.76  E-value: 3.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  36 ALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAV--FNADIFFvaIGSFIIAIAQNTTILIIGVVIAG 113
Cdd:cd17359    23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTllISAVLFF--ISALGSAFSPNFTIFIIARIIGG 100

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375544102 114 LASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSPAALFGW 175
Cdd:cd17359   101 LAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGW 162
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 5-182 1.66e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 68.37  E-value: 1.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   5 KVKLSKANVLLIIVAGLASYMDAALLVSLgvaLPIW-TKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFN 83
Cdd:cd17325   193 RLLLRDRRLLALFLAIFVLAFAFGALEPF---LPLYaAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLIL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  84 ADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFI-GFITA 162
Cdd:cd17325   270 IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLgGFLYD 349

                         170       180
                  ....*....|....*....|
gi 1375544102 163 NSGMGSPAALFGWIGLVAII 182
Cdd:cd17325   350 AFGFATPFLAAAALLLLAAV 369
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 44-182 2.45e-12

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 67.98  E-value: 2.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  44 LALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTS 123
Cdd:cd17315    29 FGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLV 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1375544102 124 LAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSPAALFGWIGLVAII 182
Cdd:cd17315   109 PLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWRLMFALAAVPALL 167
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 47-405 3.34e-12

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 68.12  E-value: 3.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  47 NSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAV 126
Cdd:TIGR00898 125 DAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 127 ISERMSSKVYGRAISSTQIFWTIGILLSQFIG-FITANSGMGSPAALFGWIGLVAIinWCV------------------- 186
Cdd:TIGR00898 205 NTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAyFIPDWRWLQLAVSLPTFLFFLLS--WFVpesprwlisqgrieealki 282

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 187 --RVFSKRFKQIETDLVDHEHVDCASngQSVKKYRLGQLLRTGG-----LLVPMILLTVFYLFWNLPANTWGSFVNYFLv 259
Cdd:TIGR00898 283 lqRIAKINGKKLPAEVLSLSLEKDLS--SSKKQYSFLDLFRTPNlrkttLCLMMLWFTTAFSYYGLVLDLGNLGGNIYL- 359

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 260 tvdgrTQAYSTIVALIANIVCLLVnliylkVSDTRYRYRVMYLGIAVALLSFVTAGIFSD-DWQIFTVVYIFYSGSTVLC 338
Cdd:TIGR00898 360 -----DLFISGLVELPAKLITLLL------IDRLGRRYTMAASLLLAGVALLLLLFVPVDlYFLRTALAVLGKFGITSAF 428

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 339 gEALYkIWSQTFYPVDARATMTGFSYGLVRVltaaFSLVTP---TLMGYSPQLLLWIMVGCTVLFGACAV 405
Cdd:TIGR00898 429 -QMVY-LYTAELYPTVVRNLGVGVCSTMARV----GSIISPflvYLGEKWLFLPLVLFGGLALLAGILTL 492
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 27-184 4.60e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 67.21  E-value: 4.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  27 AALLVSLGV-----ALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQN 101
Cdd:cd17474     7 ATLLAVLGVsivdpILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 102 TTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSPAALFGWIGLVAI 181
Cdd:cd17474    87 FALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAF 166


                  ...
gi 1375544102 182 INW 184
Cdd:cd17474   167 LAI 169
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 25-411 5.95e-12

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 66.94  E-value: 5.95e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  25 MDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTI 104
Cdd:cd17371    10 LDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 105 LIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITansgMGSPAALFGWIGLV----- 179
Cdd:cd17371    90 LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALL----FPLLPPEIAWRVLFllgal 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 180 -AIINWCVRVFSKRFKQIEtdlvDHEHVdcasnGQSVKKYRLGQLLRTGGLLVPMI---LLTVFYLFWNLPANTWgsfVN 255
Cdd:cd17371   166 pALLVLFIRRFVKEPPQWQ----AARAA-----RRHFADRPSLRELFSPPLLRTTLlasLLATGALGGYYGITTW---LP 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 256 YFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIF----- 330
Cdd:cd17371   234 SYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPlgffa 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 331 ---YSGSTVLCGEAlykiwsqtfYPVDARATMTGFSYGLVRVLTAAFslvtPTLMGY-SPQLLLWIMVGCTVLFGACAVI 406
Cdd:cd17371   314 sgpFSGMGAYLTEL---------FPTAVRATAQGFCYNVGRIIGALF----PFLVGFlATSGSLGTAIAVFAAVYYIAGL 380


                  ....*
gi 1375544102 407 IVAII 411
Cdd:cd17371   381 VLALL 385
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
9-191 1.76e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 65.26  E-value: 1.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   9 SKANVLLIIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFF 88
Cdd:COG0738     3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  89 VAIGSFIIAIAQNTTILIIGVVIAGLASGAdLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGS 168
Cdd:COG0738    83 MALGLLLFALAPSYPLLLLALFLLGLGLGL-LDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL 161

                         170       180
                  ....*....|....*....|....
gi 1375544102 169 PA-ALFGWIGLVAIINWCVRVFSK 191
Cdd:COG0738   162 SWhLPYLILAVLLLLLALLFLRSK 185
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 51-415 1.85e-11

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 65.39  E-value: 1.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  51 VGLLSTMLTVAVA-----IGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQN--------TTILIIGVVIAGLASG 117
Cdd:cd17367    37 VALLSTAAVFAVGflmrpIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTyatigiwaPIILLLARLLQGLSVG 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 118 ADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSPAALFGW---IGLVAIINwcVRVFSKRFK 194
Cdd:cd17367   117 GEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGEDQMAAWGWripFLLGGVLA--VVVLWLRRG 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 195 QIETdlvdhEHVDCASNGQSVKKYRLGQLLRTGGLLVPMILLTV-----FYlfwnlpanTWGSFVNYFLVTVDGRTQAYS 269
Cdd:cd17367   195 LEET-----ESFEAIAESNEASAGTLRELRRHPRELLLVVGLTAggtlaFY--------TWTTYLQKFLVNTAGFSKGDA 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 270 TIVALIANIVCLLVNLIYLKVSDTRYRYRV-MYLGIAVALLS---FVTAGIFSDDWQIFTVVYIfySGSTVLCGEALYKI 345
Cdd:cd17367   262 TWITTAALLVFMLLQPLGGRLSDRIGRRPLlLFFGIGGTLATvplLSALDHTDSPYTAFALVLV--GLVFLSGYTSINAV 339

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375544102 346 WSQTFYPVDARATMTGFSYGLVrvlTAAFSLVTPTLMGYSPQL-LLWIMVGCTVLFGACAVIIVAIIKKTG 415
Cdd:cd17367   340 VKAELFPTHVRALGVGLPYALA---VAIFGGTAPYVALWLKSIgHEWVFFWYVAGLIAISLVVYLRMPETR 407
MFS_1 pfam07690
Major Facilitator Superfamily;
16-362 2.80e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 64.36  E-value: 2.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  16 IIVAGLASYMDAALLVSlgVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFI 95
Cdd:pfam07690   1 LFLAAFLAALGRSLLGP--ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  96 IAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFI-GFITANSGMGSPAALFG 174
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLgGLLASLFGWRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 175 WIGLVAIINWCVRVfsKRFKQIETDLVDHEHVDCASNGQSVKKYRLGQLLRTGGLLVPMILLTVFYLFwnlpantwgsfv 254
Cdd:pfam07690 159 ILSLLAAVLLLLPR--PPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP------------ 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 255 nyFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFY-SG 333
Cdd:pfam07690 225 --LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLlLG 302

                         330       340
                  ....*....|....*....|....*....
gi 1375544102 334 STVLCGEALYKIWSQTFYPVDARATMTGF 362
Cdd:pfam07690 303 FGFGLVFPALNALVSDLAPKEERGTASGL 331
Sugar_tr pfam00083
Sugar (and other) transporter;
52-165 2.61e-10

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 61.90  E-value: 2.61e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  52 GLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTT---ILIIGVVIAGLASGADLPTSLAVIS 128
Cdd:pfam00083  49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWsvyQLIVGRVLVGIGVGGASVLAPMYIS 128

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1375544102 129 ERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSG 165
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTS 165
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 46-160 2.91e-10

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 61.52  E-value: 2.91e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  46 LNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGR-VAVFNADIFFVaIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSL 124
Cdd:cd17360    32 LSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRrPCILLADALFT-IGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVP 110

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1375544102 125 AVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFI 160
Cdd:cd17360   111 LYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGA 146
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 16-162 1.57e-09

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 59.21  E-value: 1.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  16 IIVAGLASYMDAALLVSLGVALPI-----WTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVA 90
Cdd:cd17364     1 IIIAGMGFFTDAYDLFSISLVTKIlgrlyYGGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMI 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1375544102  91 IGSFIIAIAQNTT------ILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITA 162
Cdd:cd17364    81 IGTILSALSPGSTplgvmgWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILS 158
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 21-182 1.87e-09

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 59.11  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  21 LASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQ 100
Cdd:cd17321     3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 101 NTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFI-GFITANSGMGSPAALFGWIGLV 179
Cdd:cd17321    83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLgGLLLELFGWRWIFLINVPIGLV 162


                  ...
gi 1375544102 180 AII 182
Cdd:cd17321   163 ALL 165
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 17-152 2.89e-09

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 58.78  E-value: 2.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  17 IVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFII 96
Cdd:cd17438     2 FVLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1375544102  97 AIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGIL 152
Cdd:cd17438    82 SFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGL 137
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
12-411 3.00e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 58.35  E-value: 3.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  12 NVLLIIVAGLASYMDAALLVSLGVALPiwtKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAI 91
Cdd:COG2223     6 VLLLATLAFFLAFGVWYLWSVLAPPLA---EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  92 GSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSgMGSPAA 171
Cdd:COG2223    83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA-FGWRNA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 172 LFGWIGLVAIINWCVRVFSKrfkqietdlvDHEHVDCASNGQSVKKYRlgQLLRTGGLlvpmILLTVFYLFWNLPANTWG 251
Cdd:COG2223   162 FLILGILLLVVAVLAWLFLR----------DPPAGAAAAAKASLRDQL--EALRDPRF----WLLSLLYFGTFGSFIGFS 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 252 SFVNYFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFY 331
Cdd:COG2223   226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLL 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 332 SGSTVLCGEALYKIWSQTFyPVDARATMtgfsYGLVRVLTAAFSLVTPTLMGYSPQLLLWIMVGCTVLFGACAVIIVAII 411
Cdd:COG2223   306 GLALGGGNGAVFALVPDIF-PTKNAGAV----YGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTL 380
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 52-159 3.46e-09

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 58.36  E-value: 3.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  52 GLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGAdlpTSLAV---IS 128
Cdd:cd17358    44 SWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGA---ASVVVpvyIA 120

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1375544102 129 ERMSSKVYGRAISSTQIFWTIGILLSQFIGF 159
Cdd:cd17358   121 EIAPKNVRGALGSLNQLLVNIGILLGYVLGS 151
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 16-410 7.19e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 57.21  E-value: 7.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  16 IIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFI 95
Cdd:cd17365     1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  96 IAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSgmgspaalFGW 175
Cdd:cd17365    81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPA--------FGW 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 176 IGLVaiinwcvrvfskrfkqietdlvdhehvdcasngqsvkkyrlgqLLRTGGLLVPMILLTVFYLFWNlpANTWGSFVN 255
Cdd:cd17365   153 RSVF-------------------------------------------LLGGVPPLILLPLLRGTLLLWV--TFFMGLLLV 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 256 YFLVT-------VDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFtVVY 328
Cdd:cd17365   188 YLLNSwlpklmvEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLL-YVL 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 329 IFYSGSTVLCGEALYKIWSQTFYPVDARATMTGFSYGLVRVLTAAFSLVTPTLMGYSPQlLLWIMVGCTVLFGACAVIIV 408
Cdd:cd17365   267 VFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLG-PESVFLALAIPAALGALAVL 345


                  ..
gi 1375544102 409 AI 410
Cdd:cd17365   346 LL 347
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
11-182 1.04e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.80  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  11 ANVLLIIVAGLASYMDAALLVSLGValPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFV- 89
Cdd:COG2271   180 LRFWLLALAYFLVYFALYGFLTWLP--TYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLl 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  90 -AIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQF-IGFITANSGMG 167
Cdd:COG2271   258 aALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLlVGYLLDATGYQ 337

                         170
                  ....*....|....*
gi 1375544102 168 SPAALFGWIGLVAII 182
Cdd:COG2271   338 AAFLLLAALALLAAL 352
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 19-158 1.75e-08

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 56.05  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  19 AGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAI 98
Cdd:cd17503     1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  99 AQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISstqiFWTIGILLSQFIG 158
Cdd:cd17503    81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMG----LVGLVILLAPAIG 136
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 13-330 1.92e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 56.02  E-value: 1.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  13 VLLIIVAGLASYMDAALLVSLgvaLPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIG 92
Cdd:cd17324     1 LLALALAAFAIGTTEYVIQGL---LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  93 SFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANsgMGSPAAL 172
Cdd:cd17324    78 NLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ--LLGWRAA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 173 FGWIGLVAIInwCVRVFSKRFKQIETdlvdhehvdcASNGQSVKKYRLGQLLRTGGL----LVPMILLTVFYLFWnlpan 248
Cdd:cd17324   156 FLAIAVLALL--AALLLWRLLPSLPP----------KKPGSLGLLSSLLLLLRNPRLrlayLITFLLFGGFFALY----- 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 249 twgSFVNYFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVY 328
Cdd:cd17324   219 ---TYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLV 295


                  ..
gi 1375544102 329 IF 330
Cdd:cd17324   296 LW 297
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 47-153 4.33e-08

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 54.66  E-value: 4.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  47 NSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAV 126
Cdd:cd17379    31 DAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVL 110

                          90       100
                  ....*....|....*....|....*...
gi 1375544102 127 ISERMSSKvYGRAISST-QIFWTIGILL 153
Cdd:cd17379   111 VTEFVGSK-YRRTVGIVyQMFFTLGLLI 137
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 13-161 4.71e-08

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 55.04  E-value: 4.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  13 VLLIIVAGLASYM---DAALLVSLgVALPIWTKYLALN------SWMVGLLSTMLTVAVAIGSFVGGWLSDKFGR-VAVF 82
Cdd:TIGR00879  27 ALLSLIAAIGGLMfgyDTGVIGGA-LALPAFEFKFTSAnsdsysSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRkKSLL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  83 NADIFFVAIGSFIIAI--AQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFI 160
Cdd:TIGR00879 106 IIALLFVIGAILMGLAafALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGFGSG 185


                  .
gi 1375544102 161 T 161
Cdd:TIGR00879 186 K 186
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 30-182 9.83e-08

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 53.90  E-value: 9.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  30 LVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGV 109
Cdd:cd17362    20 LLSITSPALSGTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGR 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1375544102 110 VIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSpAALFGWIGLVAII 182
Cdd:cd17362   100 LIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGW-RYMYGLAAPPALL 171
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 51-158 1.67e-07

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 52.57  E-value: 1.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  51 VGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISER 130
Cdd:cd17502    32 VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADL 111

                          90       100
                  ....*....|....*....|....*...
gi 1375544102 131 MSSKVYGRAISSTQIFWTIGILLSQFIG 158
Cdd:cd17502   112 VPPRERGKYQGYIGAVFGIASVAGPLIG 139
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
14-129 1.79e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.98  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  14 LLIIVAGLASYMdaALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGS 93
Cdd:COG2211   231 LLLLLAYLLFFL--ALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1375544102  94 FIIAIAQ--NTTILIIGVVIAGLASGADLPTSLAVISE 129
Cdd:COG2211   309 LLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLAD 346
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 13-182 2.20e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 52.56  E-value: 2.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  13 VLLIIVAGLASYMdaalLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNAdIFFVAIG 92
Cdd:cd17478   198 LLLLIIVFLRSWV----LSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIA-SLLLAAP 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  93 SFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVyGRAISSTQIF-WTIGILLSQFIGFITANSGMGSPAA 171
Cdd:cd17478   273 FLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELLPGNV-GLASGLMMGLsFGLGGIGAPVLGALADAFGLESVLL 351

                         170
                  ....*....|.
gi 1375544102 172 LFGWIGLVAII 182
Cdd:cd17478   352 ILALLPLLGAL 362
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 50-182 2.21e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 52.58  E-value: 2.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  50 MVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISE 129
Cdd:cd17473   234 LIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMS 313

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1375544102 130 RMSSKVYGRAISstqiFWTIGILLSQFIG---FITANSGMGSPAALFGWIGLVAII 182
Cdd:cd17473   314 LVPPELRGRAMG----IVTSAFFLGQFLSplvLGPLVNLTGGLSGAFLILGVLALV 365
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 37-182 5.98e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.06  E-value: 5.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  37 LPIWTKylALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLAS 116
Cdd:cd17489   217 LPLYAA--ERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGF 294

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1375544102 117 GADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFI-GFITANSGMGSPAALFGWIGLVAII 182
Cdd:cd17489   295 GLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLlGLVAELFGYRAMFLLAAVVVLLALV 361
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 15-150 6.35e-07

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 51.52  E-value: 6.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  15 LIIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGR----VAVFNADIFFVA 90
Cdd:TIGR01299 168 LFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRkqclLICLSVNGFFAF 247

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  91 IGSFIiaiaQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIG 150
Cdd:TIGR01299 248 FSSFV----QGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIG 303
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 51-406 8.40e-07

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 50.99  E-value: 8.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  51 VGLLSTMLTVAVA-----IGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAI----AQ----NTTILIIGVVIAGLASG 117
Cdd:cd17369    41 AGTLAAFATFGVGflarpLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLlptyAQigilAPILLVLLRLLQGLALG 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 118 ADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITanSGMGSPAALFGW---------IGLVAIINWCvrv 188
Cdd:cd17369   121 GEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLL--SALLSDEAFLSWgwripfllsAVLVAVGLYI--- 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 189 fskRFKQIETDlvdhEHVDCASNGQSVKKYRLGQLLRT-GGLLVPMILLTVFYLFWNLpantWGSFVNYFLVTVDGRTQA 267
Cdd:cd17369   196 ---RLRLEETP----VFRRAKEAGQVVRAPLVEVLRRHwRALLLAIGLRLAENVLFYL----FTTFALSYATQTLGVDRS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 268 YSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFYSGSTVLCGeALYKIWS 347
Cdd:cd17369   265 TVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHG-MMYGPQA 343

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1375544102 348 QTF---YPVDARATMTGFSYGLVRVLTAAFSLVTPTLM---GYSPQLLLWIMVGCTVLFGACAVI 406
Cdd:cd17369   344 AFLaelFPTRVRYTGASLGYQLGAILGGGFAPLIATALvaaTGSWWPVALYLAALAVISLVAALF 408
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
13-181 1.08e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 50.64  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  13 VLLIIVAGLASYMDAALlVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIG 92
Cdd:COG2807    18 LLLLAIVLVALNLRPAI-TSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  93 SFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVyGRAISSTQIFWTIGILLSQFIGFITANSGmGSPAAL 172
Cdd:COG2807    97 LLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGLTVPLAAAL-GWRGAL 174


                  ....*....
gi 1375544102 173 FGWIGLVAI 181
Cdd:COG2807   175 AVWALLALL 183
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 41-407 1.11e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 50.30  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  41 TKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADL 120
Cdd:cd17329    27 HQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFE 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 121 PTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSP-AALFGWIGLVAIINWcvrvfskrfkqietD 199
Cdd:cd17329   107 PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLfLAAAVLFLLAALVLL--------------F 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 200 LVDHEHVDCASNGQSVKKYRLGQLLRTGGLLVPMILLTVFYLFWNLPANTWGSFVNYFLVTVdgrTQAYSTIVALIANIV 279
Cdd:cd17329   173 LLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG---ESLLGLLLALNALLI 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 280 CLLVNLIyLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFYSGSTVLcgEALYKIWSQTFYPVDARATM 359
Cdd:cd17329   250 VLLQFPV-ARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLV--FPAVQTLVAALAPPDKRGSY 326

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1375544102 360 TGFSYGLVRVLTAAFSLVTPTLMGYSPQLLLWIMVGCTVLFGACAVII 407
Cdd:cd17329   327 MGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 47-161 1.11e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 50.27  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  47 NSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAV 126
Cdd:cd17317    23 RDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVL 102

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1375544102 127 ISERMSSKVYGRAISSTQIFWTIGILLSQFIGFIT 161
Cdd:cd17317   103 GMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLI 137
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 32-192 1.39e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 49.86  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  32 SLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVI 111
Cdd:cd17478    14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 112 AGLASGADLPTSLAVISeRMSSKVYGRAISSTQIFWTIGILLSQFI-GFITANSGMGSPAALFGWIGLVAIINWCVRVFS 190
Cdd:cd17478    94 AGIGSAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIaAALVALFGGLGLLILLIIPGLAVALLLLRLRPL 172


                  ..
gi 1375544102 191 KR 192
Cdd:cd17478   173 KK 174
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 13-182 1.41e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 49.88  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  13 VLLIIVAGLASYMDAallVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIG 92
Cdd:cd17319     5 IPLLFLAYVINYLDR---VNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  93 SFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIG-ILLSQFIGFITansGMGSPAA 171
Cdd:cd17319    82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGaAIGPPLSGWLL---LLFGWRW 158

                         170
                  ....*....|.
gi 1375544102 172 LFGWIGLVAII 182
Cdd:cd17319   159 AFIIEGLLGLL 169
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 56-160 1.42e-06

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 50.26  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  56 TMLTVAVAIGSFVGGWLSDKFGR-VAVFNADIFFVAiGSFIIAIAQNTTILIIGVVIAGLASGAdlpTSLAV---ISERM 131
Cdd:cd17433    48 SVVTLGAAAGGVLGGWIVDRAGRkLSLMLCSVPFIA-GFTVITAAQNVWMLYVGRLLTGLASGV---TSLVVpvyISEIA 123

                          90       100
                  ....*....|....*....|....*....
gi 1375544102 132 SSKVYGRAISSTQIFWTIGILLSQFIGFI 160
Cdd:cd17433   124 HPRVRGTLGSCVQLMVVIGIMGAYLAGLV 152
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 53-165 1.62e-06

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 49.94  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  53 LLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMS 132
Cdd:cd17361    55 LFTSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMAP 134

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1375544102 133 SKVYGRAISSTQIFWTIGILLSQFIGFITANSG 165
Cdd:cd17361   135 AKLRGALNIGFQLAITIGILIANLINYGTSKIK 167
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 16-324 2.34e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 49.13  E-value: 2.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  16 IIVAGLASYMDAALLVSLgvaLPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFI 95
Cdd:cd17489     1 ILLANFFFFLSFYLLLPV---LPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  96 IAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIG-FITANSGMGSPAALFG 174
Cdd:cd17489    78 YLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGlFLYQHLGFAVLFIVAA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 175 WIGLVAIinwcVRVFSKRFKQIetdlvdhehvdcASNGQSVKKYRLGQLLRTGGLLVPMILLTVFYLfwnlpanTWGSFV 254
Cdd:cd17489   158 VLALLAL----LLVFLVKDPPP------------VAAEEAEAGTRAFRRLVEKKVLPPALILFLASI-------AYGAIS 214

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 255 NYFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIF 324
Cdd:cd17489   215 TFLPLYAAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLL 284
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 17-153 2.94e-06

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 49.07  E-value: 2.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  17 IVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFII 96
Cdd:cd17372     2 AYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1375544102  97 AIAQNTTILIIGVVIAGLASGAdLPTSLAVISERMSSKVYGRAISSTQIFWTIGILL 153
Cdd:cd17372    82 AFAPNYMWLIILRCLVGLGLGG-GPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIF 137
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 18-159 3.25e-06

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 49.02  E-value: 3.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  18 VAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIA 97
Cdd:cd17363     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSS 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375544102  98 IAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGF 159
Cdd:cd17363    83 FVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAW 144
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 5-187 3.94e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.77  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   5 KVKLSKANVLLIIVAGLAsymdAALLVSLGVALPIWTK-YLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFN 83
Cdd:cd06173   203 YLRRSPLLRLLLLALALF----ALLGGALTVLLPLLAKeVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  84 ADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITAN 163
Cdd:cd06173   279 IGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD 358

                         170       180
                  ....*....|....*....|....
gi 1375544102 164 SGMGSPAALFGWIGLVAIINWCVR 187
Cdd:cd06173   359 ALGLSAVFLLAGALLLLAALLLLL 382
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 4-182 4.32e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 48.31  E-value: 4.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   4 EKVKLSKANVLLIIVAGL--ASYMDAALLVslgvalpIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAV 81
Cdd:cd17370   194 SLKKLPKAFWLYLLAVALfaLGNFSFAFLI-------LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKL 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  82 FNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFI-GFI 160
Cdd:cd17370   267 LILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIaGYL 346

                         170       180
                  ....*....|....*....|..
gi 1375544102 161 TANSgmgSPAALFGWIGLVAII 182
Cdd:cd17370   347 WDLI---SPSAAFLFSAVLALI 365
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 18-150 5.08e-06

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 48.49  E-value: 5.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  18 VAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIA 97
Cdd:cd17439     3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSS 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1375544102  98 IAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIG 150
Cdd:cd17439    83 FVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIG 135
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
3-333 5.40e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.36  E-value: 5.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   3 DEKVKLSKANVLLIIVAGLASYMDAALLVSLgvALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSD----KFGR 78
Cdd:COG2211     2 AAKKKLSLKEKLAYGLGDLGLNLAFGLLSAY--LLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  79 VAVFnadIFFVAIGSFIIAIAQ----------NTTILIIGVVIAGLASGADLPTSLAVISER-MSSKVYGRAISSTQIFW 147
Cdd:COG2211    80 RRPW---ILIGAIPLALSFVLLftapdlsptgKLIYALVTYLLLGLAYTLVNIPYSALGAELtPDYEERTRLSSWRFAFA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 148 TIGILLSQFIGFITANSGMGSPA----ALFGWIGLVAIINWCVRVFSKRfkqiETDLVDHEHVDCASNGQSVKKYRlgql 223
Cdd:COG2211   157 GLGGLLASVLPPPLVAAFGGDAAlgyrLTALIFAVLGLLAFLLTFFGTK----ERPVPEEEKVSLKESLKALLKNR---- 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 224 lrtggllvPMILLTVFYLFWNLPANTWGSFVNYFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYRYRVMYLG 303
Cdd:COG2211   229 --------PFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300

                         330       340       350
                  ....*....|....*....|....*....|
gi 1375544102 304 IAVALLSFVTAGIFSDDWQIFTVVYIFYSG 333
Cdd:COG2211   301 LLLAALGLLLLFFLGPGNLWLLLVLAALAG 330
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 35-411 7.85e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.61  E-value: 7.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  35 VALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGR---VAVFNADIFFVAIGSFIIAIAQNTTI--LIIGV 109
Cdd:cd06173    20 VALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRrrlLILADLLRALLAAVLALLALLGSLSLwlLLVLA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 110 VIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFI-GFITANSGMGSPAAL-FGWIGLVAIINWCVR 187
Cdd:cd06173   100 FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALgGLLVALLGPGGAFAInALSFLLSALLLLFIR 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 188 vfskrfkqietdLVDHEHVDCASNGQSVKKYRLGQLLRTGGLLVPMILLTVFYLFWNlpANTWGSFVNYFLVTVDGRTQA 267
Cdd:cd06173   180 ------------RPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLG--GALTVLLPLLAKEVLGGGAAG 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 268 YSTIVALIAnIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIFYSGStvlcgeALYKIWS 347
Cdd:cd06173   246 YGLLLAAFG-VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAG------GLFNVPL 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1375544102 348 QTFYPVDARATMTGFSYGLVRVLTAAFSLVTPTLMGYspqLLLWIMVGCTVLFGACAVIIVAII 411
Cdd:cd06173   319 NTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL---LADALGLSAVFLLAGALLLLAALL 379
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 13-158 7.89e-06

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 47.76  E-value: 7.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  13 VLLIIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIG 92
Cdd:TIGR00711   1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375544102  93 SFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAIsstqIFWTIGILLSQFIG 158
Cdd:TIGR00711  81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAM----AIWGLTVLVAPALG 142
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 45-163 8.80e-06

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 47.63  E-value: 8.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  45 ALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGsFIIAIAQNTTI--LIIGVVIAGLASGADLPT 122
Cdd:cd17356    41 YPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIG-AIIQVAAIGKWyqLIVGRIIAGLGVGFASVL 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1375544102 123 SLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITAN 163
Cdd:cd17356   120 VPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHK 160
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 30-141 9.13e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 47.65  E-value: 9.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  30 LVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGV 109
Cdd:PRK11551   31 LQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVAR 110

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1375544102 110 VIAGLASGADLPTSLAVISERMSSKVYGRAIS 141
Cdd:PRK11551  111 LLTGVGLGGALPNLIALTSEAVGPRLRGTAVS 142
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 13-158 1.71e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 46.80  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  13 VLLIIVAGLASYMDAALLVSlgvALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIG 92
Cdd:cd17323     1 VFIISFLTFVVTFGSSIYSP---ALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIF 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375544102  93 SFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISstqiFWTIGILLSQFIG 158
Cdd:cd17323    78 QIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMG----VYSLGPLLGPALG 139
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 8-182 2.69e-05

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 46.46  E-value: 2.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102    8 LSKANVLLIIVAGLASYMDAALLVSLgvALPIWTK-YLALNSWM-VGLLSTMLTVAVAIGSFVGGWLSDK---FGRVAVf 82
Cdd:PRK08633   228 LRSDRVLWLAIIGLSYFWFISQLAQA--NFPAYAKeVLGLDNTFqVQYLLAASAIGIGIGSLLAGRLSGRhieLGLVPL- 304

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   83 naDIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGA-DLPTSlAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFIT 161
Cdd:PRK08633   305 --GALGLALSLFLLPTAPSLASVLVLFFLFGFSAGLfIVPLN-ALIQFRAPEKELGKVLAANNFLQNVGMLLFLALTTLF 381

                          170       180
                   ....*....|....*....|.
gi 1375544102  162 ANSGMgSPAALFGWIGLVAII 182
Cdd:PRK08633   382 SGLGL-SPAGLFYLIALVTLI 401
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 51-157 2.82e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 46.08  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  51 VGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPtSLAVISER 130
Cdd:cd06179    34 STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGL-GAAVASEL 112

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1375544102 131 MSSK----VYGRAISSTQIFWTIGILLSQFI 157
Cdd:cd06179   113 VPNKyrglVQGVVNLVASPGSALGPLIAGAL 143
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 36-158 3.99e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 45.64  E-value: 3.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  36 ALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLA 115
Cdd:cd17320    21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1375544102 116 SGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIG 158
Cdd:cd17320   101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLG 143
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 44-182 9.93e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 44.11  E-value: 9.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  44 LALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGAdLPTS 123
Cdd:cd17330    29 LGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-VSVA 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1375544102 124 LAVISERMSSKVYGRAISSTQIFWTIGILLSQFI-GFITANSGMGSP---AALFGWIGLVAII 182
Cdd:cd17330   108 QAYIADITDEEERAKAFGIISAAFGLGFILGPALgGFLSTPYGYALPflvAAALALLNLVLVL 170
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 70-337 9.99e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 44.13  E-value: 9.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  70 GWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGlaSGADLPTSLAVISERMSSKVYGRAIS----STQI 145
Cdd:cd17472    53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMAligaSIGI 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 146 FWTIGILLSQFIGFITANSGMGSPAALFGWIGLvaIINWCVRVFSKRFKQIEtdlvdhehvdcASNGQSVKKYRLGQLLR 225
Cdd:cd17472   131 AFAISMVLGPLLAAHLGVSGLFLITAILSLVSL--LILLFFVPDPPKIVQIS-----------EKEKKKLKKLLKNKRLL 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 226 TGGLLVPMILLTVFYLFWNLPantwgsfvnyFLVTVDGRTQAYSTIVALIANIVCLLVNLIYLKVSDTRYR-YRVMYLGI 304
Cdd:cd17472   198 RLDFSIFILHFVLMAFFYILP----------LLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKmKQVFVSSI 267

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1375544102 305 AVALLSFVTAGIFSDD-WQIFTVVYIFYSGSTVL 337
Cdd:cd17472   268 LLIAVGFLLLLFAATSlWLLIIGLIIFFIGFNLL 301
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 51-182 1.81e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 43.33  E-value: 1.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  51 VGLLSTMLTVAVAIGSFVGGWLSDKFGRVA---VFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVI 127
Cdd:cd17319   217 VGLLAAIPFLAGAIGMILGGRLSDRLLRGArrlVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLP 296

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1375544102 128 SERMSSKVYGRAISSTQ-IFWTIGILLSQFIGFITANSgmGSPAALFGWIGLVAII 182
Cdd:cd17319   297 ADLLPGEAAATAGGLINsGGNLGGFVAPLLIGYLVDAT--GSYTAAFLFLAAVALL 350
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 18-150 1.86e-04

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 43.75  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  18 VAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGR----VAVFNADIFFVAIGS 93
Cdd:cd17440     3 VLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRrqslLICMSVNGFFAFLSS 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1375544102  94 FIiaiaQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIG 150
Cdd:cd17440    83 FV----QGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIG 135
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 27-186 2.13e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 43.37  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  27 AALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTIL- 105
Cdd:cd17353   227 TAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLf 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 106 IIGVVIAGLASGADLPTSLAVIS----ERMSSKVYGRAISSTQIFWTIGILLSQFIgfitanSGMGSPAALFGWIGLVAI 181
Cdd:cd17353   307 VLGVALIGFCYGGGFALFPALTAdffgTKNAGTNYGLLYTAKGVGGLIGPIIAAYV------LYTGGYNAAFIIAAALSL 380


                  ....*
gi 1375544102 182 INWCV 186
Cdd:cd17353   381 VALAL 385
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 27-166 2.82e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.93  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  27 AALLVSLGVALPIWTKYLALN---SWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTT 103
Cdd:cd17477     6 ALLGLGSGLLLPLLSLRLEREgvsTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1375544102 104 ILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGM 166
Cdd:cd17477    86 VWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGA 148
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 48-184 3.34e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 3.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  48 SWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVI 127
Cdd:cd17473    34 ELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALI 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1375544102 128 SERMSskvygraisstqifwtiGILLSQFIGFITANSGMGSpAALFGWIGLVAIINW 184
Cdd:cd17473   114 GDYFE-----------------GEERAKMLGLQSAAMSLGG-VVFLLLGGALAEIGW 152
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 58-189 3.40e-04

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 42.63  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  58 LTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISeRMSSKVYG 137
Cdd:cd17393   244 FSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAG-ALPGLAAG 322

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1375544102 138 RAISSTQIFWTIGILLSQF-IGFITANSGMgsPAALFGWIGLVAIINWCVRVF 189
Cdd:cd17393   323 IAVARVATLGYLGFLVGPPlIGFLADATGL--RTAFLVVALLALLVALLARAV 373
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 17-130 4.92e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 42.18  E-value: 4.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  17 IVAGLASYMDAALLVSlgvALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFII 96
Cdd:cd17504     2 ALAALAVMLVETMLSP---ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLA 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1375544102  97 AIAQNTTILIIGVVIAGLASGAdLPTSLAVISER 130
Cdd:cd17504    79 AFAPNLPVLIAGRALQGIGGAV-FPLAFALVREE 111
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 37-411 5.74e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 5.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  37 LPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFG-RVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLA 115
Cdd:cd17370    22 LPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 116 SGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSPAALFGWIGLVAIINWCVRVFSKRFKQ 195
Cdd:cd17370   102 KGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALLILLFVVKEYP 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 196 IETDLVDHEHvdcasngqSVKKYRLGQLLRtgGLLVPMILLTVFYLFWNLPAntwgsfvnyFLVTVDGRTQAYSTIVALI 275
Cdd:cd17370   182 RPPKLRKKSK--------KTSLKKLPKAFW--LYLLAVALFALGNFSFAFLI---------LRAQELGLSAALIPLLYAL 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102 276 ANIVCLLVNLIYLKVSDTRYRYRVMYLGIAVALLSFVTAGIFSDDWQIFTVVYIF--YSGSTvlcgEALYKIWSQTFYPV 353
Cdd:cd17370   243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWglYMGAQ----ESIERAAVADLVPA 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1375544102 354 DARATmtgfSYGLVRVLTAAFSLVTPTLMGYspqLLLWIMVGCTVLFGACAVIIVAII 411
Cdd:cd17370   319 ELRGT----AYGLFNTVVGIGWLLASLIAGY---LWDLISPSAAFLFSAVLALIALLL 369
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 52-182 7.47e-04

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 41.55  E-value: 7.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  52 GLLSTMLTVAVAI-------GSFVGGWLSDKFGRV-AVFNADIFFVAIGSFI--IAIAQNTTILIIGVVIAGLASGadLP 121
Cdd:cd17431    46 ETLTTLWSLSVAIfsvggmiGSFSVGLFVNRFGRRnSMLYNNLLAFAGAALMglSKLAKSYEMLILGRFIIGLYCG--LT 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375544102 122 TSLA--VISERMSSKVYGRAISSTQIFWTIGILLSQFIGFitaNSGMGSPAA---LFGWIGLVAII 182
Cdd:cd17431   124 TGLVpmYIGEISPTALRGALGTLHQLGIVVGILISQIFGL---EFILGTEELwplLLGFTIVPAIL 186
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 32-182 7.77e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 41.59  E-value: 7.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  32 SLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVI 111
Cdd:TIGR00881  13 NFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWAL 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1375544102 112 AGLASGADLPTSLAVISERMSSKVYGRAISstqiFWTI-----GILLSQFIGFITANsgMGSPAALFGWIGLVAII 182
Cdd:TIGR00881  93 NGIFQGMGWPPCGRTVTKWFSRSERGTWVS----FWNCshnvgGGLLPPLVLFGIAE--LYSWHWVFIVPGIIAII 162
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
52-133 8.79e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 41.40  E-value: 8.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  52 GLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERM 131
Cdd:COG2807   253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRA 332


                  ..
gi 1375544102 132 SS 133
Cdd:COG2807   333 RT 334
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 14-182 1.20e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 40.64  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  14 LLIIVAGLASYMDAALLVSLGVALPIWtkyLALNSWMVGLLSTMLTVAVAIGS-FVGGWLSDKFGRVAVFNADIFFVAIG 92
Cdd:cd17330   178 RLLLVYFLIALAFAGLESVFSLFLKDR---FGFSPSQIGLLLALVGIAGILAQlLLIPRLAKRLGERKLLRLGLLLAIIG 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  93 SFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAI----SSTQIFWTIGILLsqfIGFITANSGMGS 168
Cdd:cd17330   255 LLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQgiiqSLQSLARIIGPLL---AGPLYSFLGPGV 331

                         170
                  ....*....|....
gi 1375544102 169 PAALFGWIGLVAII 182
Cdd:cd17330   332 PFLLAAGLLLIALF 345
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 13-160 1.32e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 40.87  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  13 VLLIIVAGLASYMDAALLVSLGVALPI-----WTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIF 87
Cdd:TIGR00887  15 FRAIVIAGVGFFTDSYDLFCISLVTKMlgyvyYHGKGPLPSSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELI 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1375544102  88 FVAIGSF-IIAIAQNTTILIIGV-----VIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFI 160
Cdd:TIGR00887  95 IMIIATVaSGLSPGSSPKSVMATlcfwrFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQGFGILAGAIVALI 173
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 60-182 1.35e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 40.61  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  60 VAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISeRMSSKVYGRA 139
Cdd:cd17324   245 VAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL-RLAPEARGLA 323

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1375544102 140 ISSTQIFWTIGILLSQFI-GFITANSGMGSPAALFGWIGLVAII 182
Cdd:cd17324   324 SSLYLAAYNLGGALGAALgGLVLDHGGWAGVGWVGAALLLLALL 367
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 14-153 1.46e-03

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 40.56  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  14 LLIIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGS 93
Cdd:cd17442     1 LLFLIMGSTGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1375544102  94 FIIAIAQNTTILI-----IGVVIAGLASGadlptsLAVISERMSSKVYGRAISSTQIFWTIGILL 153
Cdd:cd17442    81 LLTSFAPSYIWFVflrcmVGCGVSGHSQG------LIIKTEFLPTKYRGYMLPLSQIFWLAGSLL 139
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 32-123 1.59e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 40.30  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  32 SLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVI 111
Cdd:cd17475    14 GIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFL 93

                          90
                  ....*....|..
gi 1375544102 112 AGLASGADLPTS 123
Cdd:cd17475    94 VGAGYGSVQPGG 105
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 8-137 2.42e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.85  E-value: 2.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   8 LSKANVLLIIVAGLASYMDAALLVSLGVALpiwTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIF 87
Cdd:cd17321   166 LARTFSGAVLAAFLLGAALGGLLFLLPLYL---QGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1375544102  88 FVAIGSFIIAIAQNTT---ILIIGVVIAGLASGADLPTSLAVISERMSSKVYG 137
Cdd:cd17321   243 LTAVGLLLLALLGADSsvwLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAG 295
PRK10489 PRK10489
enterobactin transporter EntS;
33-127 2.68e-03

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 39.96  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  33 LGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVfnadiffvaigsfiIAIAQNTTiliiGVVIA 112
Cdd:PRK10489   36 LGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKL--------------ILLARGTC----GLGFI 97

                          90
                  ....*....|....*.
gi 1375544102 113 GLASGADLPT-SLAVI 127
Cdd:PRK10489   98 GLALNAFLPEpSLLAI 113
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 44-159 2.75e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 39.94  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  44 LALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGR-VAVFNADIFFVAIGSFIIA--IAQNTTILIIGVVIAGLASGADL 120
Cdd:cd17357    44 DSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRkNGLLISNALLVVSSLLMFLskSAKSPELLIFGRFLVGIACGLST 123

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1375544102 121 PTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGF 159
Cdd:cd17357   124 GFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGL 162
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 44-153 3.23e-03

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 39.69  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  44 LALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGR--VAVFNADIFFVaiGSFIIAIAQNTTILIIGVVIAGLASGADLP 121
Cdd:cd17437    27 LKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRryTIALAALIFFV--GALLMGVAPNYPVLMVGRFVAGIGVGFALM 104

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1375544102 122 TSLAVISERMSSKVYGRAISSTQIFWTIGILL 153
Cdd:cd17437   105 IAPVYTAEVAPASSRGFLTSFPEIFINIGILL 136
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 48-193 4.84e-03

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 38.88  E-value: 4.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  48 SWMVGLLSTMLTVAVAIGSFVGGWLSD-KFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAV 126
Cdd:cd17378    32 SFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVL 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1375544102 127 ISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGmgspAALFGWIGLVAII-NWCVRVFSKRF 193
Cdd:cd17378   112 ATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNGSSW----RVLYFWTSIPALIyCILVYLFARRL 175
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 47-160 5.41e-03

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 38.60  E-value: 5.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  47 NSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASgadlpTSLAV 126
Cdd:cd17376    33 DDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGQ-----ISNYV 107

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1375544102 127 ISERMSSKVYGRaiSSTQIFWTIGILLSQFIGFI 160
Cdd:cd17376   108 VAFVLGTEILGK--SVRILFSTLGVCIFYAIGYM 139
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 8-150 7.79e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 38.31  E-value: 7.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102   8 LSKANVLLIIVAGLASYMDAALLVSLGVALPIWTKY-LALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVA---VFN 83
Cdd:cd17502   161 LALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLvLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKpliVIG 240

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1375544102  84 ADIFFVAIGSFIIAIAQNTTILIIGV-VIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIG 150
Cdd:cd17502   241 TILMSVGAGLLTTLTLDTSKWLLIGYlILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLG 308
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 32-158 7.97e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 38.07  E-value: 7.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  32 SLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVI 111
Cdd:cd17333    14 LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFL 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1375544102 112 AGLASGADLPTSLAVISErMSSKVYGRAISSTQIFWTIGILLSQFIG 158
Cdd:cd17333    94 AGLGAGILDTGANTFVGA-LFEESSATRLNVLHGFFGLGALIGPLIA 139
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 12-181 8.37e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.18  E-value: 8.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  12 NVLLIIVAGLASYMDAALLVSLGVALPIWTKYLALNSWMVGLLSTMLTVAVAIGSFVGGWLSDK-FGRVAVFNADIFFVA 90
Cdd:cd06174   202 NPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMA 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  91 IGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVISERMSSKVYGRAISSTQIFWTIGILLSQFIGFITANSGMGSPA 170
Cdd:cd06174   282 LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTG 361

                         170
                  ....*....|.
gi 1375544102 171 ALFGWIGLVAI 181
Cdd:cd06174   362 AFLVLAVLLLL 372
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 52-160 8.53e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 38.02  E-value: 8.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  52 GLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLaSGADLPTSLAVISERM 131
Cdd:cd17389    67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGI-SKGNVSLSTAIVADVT 145

                          90       100
                  ....*....|....*....|....*....
gi 1375544102 132 SSKVYGRAISstqifwTIGILLSqfIGFI 160
Cdd:cd17389   146 SPKKRSKGMA------LIGVAFS--LGFI 166
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 48-159 8.68e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 38.22  E-value: 8.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375544102  48 SWMVGLLSTMLTVAVAIGSFVGGWLSDKFGRVAVFNADIFFVAIGSFIIAIAQNTTILIIGVVIAGLASGADLPTSLAVI 127
Cdd:cd17377    38 AYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLL 117

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1375544102 128 SERMSSKVYGRAISSTQIFWTIGILLSQFIGF 159
Cdd:cd17377   118 NECVGKSYWALAGSLGGLFFAVGIAQYALLGY 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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