|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
477-1045 |
1.30e-145 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 458.78 E-value: 1.30e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 477 ESLPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSLV 556
Cdd:COG1643 8 PDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 557 GYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNIC-LKRNDLKLIVTSATID 635
Cdd:COG1643 88 GYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALRPDLKLLVMSATLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 636 AKKFSAFFGNAPIYNIQGRTFKVHIEYL--RTPCNDYIEC---AVQKAIQIHvsdnnydnnFGDILIFMTGQEDINATCY 710
Cdd:COG1643 168 AERFARLLGDAPVIESSGRTYPVEVRYRplPADERDLEDAvadAVREALAEE---------PGDILVFLPGEREIRRTAE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 711 LLSERFYevyesykesknnkKDTInkiknilnednnnnnndsnikkkvdgdnntndhmiypfyIFPIYSQLSSEQQSKIF 790
Cdd:COG1643 239 ALRGRLP-------------PDTE---------------------------------------ILPLYGRLSAAEQDRAF 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 791 KKYD--LRKIIVSTNIAETSLTLDGIKYVIDTGYCKLKVYNQTIGMDVLQVTPISQANANQRSGRAGRTGAGICYRLYTE 868
Cdd:COG1643 267 APAPhgRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSE 346
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 869 NTFLcDLYQNNIPEIQRSNLSNVVLLLKSLHVQNLFEFDFIDVPSKESI---INSLHElwvLGAINNEGNLTDIGRKMVQ 945
Cdd:COG1643 347 EDFA-RRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIadaRALLQE---LGALDADGRLTPLGRALAR 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 946 FPLDPPLSKIVIYSQNFQCTKEILIIVSMLSSPSIFLESkennesieskkekftvPESDHLTLLNIYLQWRSHNysyswc 1025
Cdd:COG1643 423 LPLDPRLARMLLAAAELGCLREAAILAALLSERDPRRGA----------------AGSDLLARLNLWRRLREQQ------ 480
|
570 580
....*....|....*....|
gi 1371546596 1026 tKNFIQYKALNKAKEVYSQL 1045
Cdd:COG1643 481 -REFLSYLRLREWRDLARQL 499
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
477-1143 |
7.61e-143 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 463.47 E-value: 7.61e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 477 ESLPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSLV 556
Cdd:TIGR01967 64 DNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 557 GYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATIDA 636
Cdd:TIGR01967 144 GYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDP 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 637 KKFSAFFGNAPIYNIQGRTFKVHIEYlR--TPCNDYIECAVQKAIQIHVsDNNYDNNFGDILIFMTGQEDINATCYLLSE 714
Cdd:TIGR01967 224 ERFSRHFNNAPIIEVSGRTYPVEVRY-RplVEEQEDDDLDQLEAILDAV-DELFAEGPGDILIFLPGEREIRDAAEILRK 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 715 RFYEVYEsykesknnkkdtinkiknilnednnnnnndsnikkkvdgdnntndhmiypfyIFPIYSQLSSEQQSKIFKKYD 794
Cdd:TIGR01967 302 RNLRHTE----------------------------------------------------ILPLYARLSNKEQQRVFQPHS 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 795 LRKIIVSTNIAETSLTLDGIKYVIDTGYCKLKVYNQTIGMDVLQVTPISQANANQRSGRAGRTGAGICYRLYTENTFLC- 873
Cdd:TIGR01967 330 GRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSr 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 874 DLYQNniPEIQRSNLSNVVLLLKSLHVQNLFEFDFIDVPSKESI---INSLHELWVLGAINNEGNLTDIGRKMVQFPLDP 950
Cdd:TIGR01967 410 PEFTD--PEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIrdgFRLLEELGALDDDEAEPQLTPIGRQLAQLPVDP 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 951 PLSKIVIYSQNFQCTKEILIIVSMLSSPSIFLESKENNESIESKKEKFTVPESDHLTLLNIY------LQWRSHNYSYSW 1024
Cdd:TIGR01967 488 RLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQAADQAHARFKDPRSDFLSRVNLWrhieeqRQALSANQFRNA 567
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 1025 CTKNFIQYKALNKAKEVYSQLIDIIKTLNIKNVSCDNKWELIRKTICSGYFHNAAKLKSFSEYINLRtNVSCHVHPNSSL 1104
Cdd:TIGR01967 568 CRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADYDAIHKALLSGLLSQIGMKDEKHEYDGAR-GRKFHIFPGSPL 646
|
650 660 670
....*....|....*....|....*....|....*....
gi 1371546596 1105 YniGYTPDYVIYQEIVFTTKEYMRNVTTVDPEWLCELGP 1143
Cdd:TIGR01967 647 F--KKPPKWVMAAELVETSKLYARLVAKIEPEWVEPVAG 683
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
477-1138 |
1.29e-141 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 460.68 E-value: 1.29e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 477 ESLPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSLV 556
Cdd:PRK11131 71 ENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCV 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 557 GYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATIDA 636
Cdd:PRK11131 151 GYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDP 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 637 KKFSAFFGNAPIYNIQGRTFKVHIEYlrTPCNDYIECAVQKAIQ--IHVSDNNYDNNFGDILIFMTGQEDINATCYLLSe 714
Cdd:PRK11131 231 ERFSRHFNNAPIIEVSGRTYPVEVRY--RPIVEEADDTERDQLQaiFDAVDELGREGPGDILIFMSGEREIRDTADALN- 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 715 rfyevyesykesKNNKKDTinkiknilnednnnnnndsnikkkvdgdnntndhmiypfYIFPIYSQLSSEQQSKIFKKYD 794
Cdd:PRK11131 308 ------------KLNLRHT---------------------------------------EILPLYARLSNSEQNRVFQSHS 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 795 LRKIIVSTNIAETSLTLDGIKYVIDTGYCKLKVYNQTIGMDVLQVTPISQANANQRSGRAGRTGAGICYRLYTENTFL-- 872
Cdd:PRK11131 337 GRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLsr 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 873 ---CDlyqnniPEIQRSNLSNVVLLLKSLHVQNLFEFDFIDVPSKESIINSLHELWVLGAINNEGN-----LTDIGRKMV 944
Cdd:PRK11131 417 pefTD------PEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLA 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 945 QFPLDPPLSKIVIYSQNFQCTKEILIIVSMLSSPSIFLESKENNESIESKKEKFTVPESDHLTLLNI--YLQWR----SH 1018
Cdd:PRK11131 491 QLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLAFVNLwnYLQEQqkalSS 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 1019 NYSYSWCTKNFIQYKALNKAKEVYSQLIDIIKTLNIKNVSCDNKWELIRKTICSGYF-HNAAKLKSFSEYINLRtNVSCH 1097
Cdd:PRK11131 571 NQFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHTALLTGLLsHIGMKDAEKQEYTGAR-NARFS 649
|
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 1371546596 1098 VHPNSSLYNigYTPDYVIYQEIVFTTKEYMRNVTTVDPEWL 1138
Cdd:PRK11131 650 IFPGSGLFK--KPPKWVMVAELVETSRLWGRIAARIEPEWI 688
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
479-651 |
6.54e-93 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 294.37 E-value: 6.54e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSLVGY 558
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 559 TIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATIDAKK 638
Cdd:cd17983 81 AIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDADK 160
|
170
....*....|...
gi 1371546596 639 FSAFFGNAPIYNI 651
Cdd:cd17983 161 FADFFGNVPIFTI 173
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
495-651 |
6.61e-87 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 277.42 E-value: 6.61e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 495 NNIIIIVGETGSGKTTQIVQYLYEEGY--HRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSLVGYTIRFEDNTTKDTKI 572
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLakGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1371546596 573 RYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATIDAKKFSAFFGNAPIYNI 651
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
479-651 |
1.75e-84 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 271.92 E-value: 1.75e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSLVGY 558
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 559 TIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKR-----NDLKLIVTSAT 633
Cdd:cd17978 81 SVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMSAT 160
|
170
....*....|....*...
gi 1371546596 634 IDAKKFSAFFGNAPIYNI 651
Cdd:cd17978 161 LDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
476-651 |
5.90e-83 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 267.43 E-value: 5.90e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 476 KESLPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSL 555
Cdd:cd17971 3 RESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 556 VGYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATID 635
Cdd:cd17971 83 VGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSATLD 162
|
170
....*....|....*.
gi 1371546596 636 AKKFSAFFGNAPIYNI 651
Cdd:cd17971 163 AVKFSQYFYEAPIFTI 178
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
479-980 |
2.39e-75 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 267.02 E-value: 2.39e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQI-VQYLYEEGYHRNgiICCTQPRRVAAVSVAYRVSYEMNVDIGSLVG 557
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVpLALLDAPGIGGK--IIMLEPRRLAARSAAQRLASQLGEAVGQTVG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 558 YTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNI-CLKRNDLKLIVTSATIDA 636
Cdd:TIGR01970 79 YRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVqSSLREDLKILAMSATLDG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 637 KKFSAFFGNAPIYNIQGRTFKVHIEYLRTPCNDYIECAVQKAIQIHVSDNNydnnfGDILIFMTGQEDINATCYLLSERF 716
Cdd:TIGR01970 159 ERLSSLLPDAPVVESEGRSFPVEIRYLPLRGDQRLEDAVSRAVEHALASET-----GSILVFLPGQAEIRRVQEQLAERL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 717 yevyesykesknnkkdtinkiknilnednnnnnndsniKKKVDgdnntndhmiypfyIFPIYSQLSSEQQSKIFK--KYD 794
Cdd:TIGR01970 234 --------------------------------------DSDVL--------------ICPLYGELSLAAQDRAIKpdPQG 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 795 LRKIIVSTNIAETSLTLDGIKYVIDTGYCKLKVYNQTIGMDVLQVTPISQANANQRSGRAGRTGAGICYRLYTENTFLCD 874
Cdd:TIGR01970 262 RRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQRL 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 875 LYQNNiPEIQRSNLSNVVLLLKSLHVQNLFEFDFIDVPSKESIINSLHELWVLGAINNEGNLTDIGRKMVQFPLDPPLSK 954
Cdd:TIGR01970 342 PAQDE-PEILQADLSGLALELAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAA 420
|
490 500
....*....|....*....|....*.
gi 1371546596 955 IVIYSQNFQCTKEILIIVSMLSSPSI 980
Cdd:TIGR01970 421 MLLSAHSTGLAALACDLAALLEERGL 446
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
471-651 |
3.06e-75 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 246.56 E-value: 3.06e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 471 ELLKLKESLPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNG--IICCTQPRRVAAVSVAYRVSYEM 548
Cdd:cd17973 5 EILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPkkLVACTQPRRVAAMSVAQRVAEEM 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 549 NVDIGSLVGYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLI 628
Cdd:cd17973 85 DVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKLI 164
|
170 180
....*....|....*....|...
gi 1371546596 629 VTSATIDAKKFSAFFGNAPIYNI 651
Cdd:cd17973 165 VMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
479-651 |
3.48e-75 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 245.88 E-value: 3.48e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHR-NGIICCTQPRRVAAVSVAYRVSYEMNVDIGSLVG 557
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKgGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 558 YTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATIDAK 637
Cdd:cd17974 81 YSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDAE 160
|
170
....*....|....
gi 1371546596 638 KFSAFFGNAPIYNI 651
Cdd:cd17974 161 KFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
479-651 |
1.20e-68 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 227.82 E-value: 1.20e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSLVGY 558
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 559 TIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRN-----DLKLIVTSAT 633
Cdd:cd17984 81 QVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSAT 160
|
170
....*....|....*...
gi 1371546596 634 IDAKKFSAFFGNAPIYNI 651
Cdd:cd17984 161 LELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
479-643 |
2.04e-68 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 227.35 E-value: 2.04e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNG-IICCTQPRRVAAVSVAYRVSYEMNVDIGSLVG 557
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGrVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 558 YTIRFEDNTTKD-TKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATIDA 636
Cdd:cd17980 81 YCIRFDDCTDPQaTRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160
|
....*..
gi 1371546596 637 KKFSAFF 643
Cdd:cd17980 161 EKFRDFF 167
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
479-648 |
2.29e-64 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 215.40 E-value: 2.29e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSLVGY 558
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 559 TIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATIDAKK 638
Cdd:cd17989 81 KVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDAER 160
|
170
....*....|
gi 1371546596 639 FSAFFGNAPI 648
Cdd:cd17989 161 FSRHFNNAPI 170
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
478-962 |
5.29e-64 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 233.66 E-value: 5.29e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 478 SLPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQI-VQYLYEEGyhRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSLV 556
Cdd:PRK11664 3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLpLQLLQHGG--INGKIIMLEPRRLAARNVAQRLAEQLGEKPGETV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 557 GYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNI--CLkRNDLKLIVTSATI 634
Cdd:PRK11664 81 GYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVqqGL-RDDLKLLIMSATL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 635 DAKKFSAFFGNAPIYNIQGRTFKVHIEYLRTPCNDYIECAVQKAIQihvsdNNYDNNFGDILIFMTGQEDINATCYLLSE 714
Cdd:PRK11664 160 DNDRLQQLLPDAPVIVSEGRSFPVERRYQPLPAHQRFDEAVARATA-----ELLRQESGSLLLFLPGVGEIQRVQEQLAS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 715 RFYEvyesykesknnkkDTInkiknilnednnnnnndsnikkkvdgdnntndhmiypfyIFPIYSQLS-SEQQSKIF-KK 792
Cdd:PRK11664 235 RVAS-------------DVL---------------------------------------LCPLYGALSlAEQQKAILpAP 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 793 YDLRKIIVSTNIAETSLTLDGIKYVIDTGYCKLKVYNQTIGMDVLQVTPISQANANQRSGRAGRTGAGICYRLYTENTFL 872
Cdd:PRK11664 263 AGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAE 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 873 CDLYQNNiPEIQRSNLSNVVLLLKSLHVQNLFEFDFIDVPSKESIINSLHELWVLGAINNEGNLTDIGRKMVQFPLDPPL 952
Cdd:PRK11664 343 RAAAQSE-PEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRL 421
|
490
....*....|
gi 1371546596 953 SKIVIYSQNF 962
Cdd:PRK11664 422 AAMLVAAKED 431
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
479-647 |
6.42e-63 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 212.21 E-value: 6.42e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGY-----HRNGIICCTQPRRVAAVSVAYRVSYEMNVdIG 553
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFgspesDNPGMIGITQPRRVAAVSMAKRVAEELNV-FG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 554 SLVGYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRND--------- 624
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159
|
170 180
....*....|....*....|....*..
gi 1371546596 625 -LKLIVTSATIDAKKFSA---FFGNAP 647
Cdd:cd17982 160 pLKLVIMSATLRVEDFTEnklLFPRPP 186
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
656-866 |
4.28e-58 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 197.37 E-value: 4.28e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 656 FKVHIEYLRTP-----------CNDYIECAVQKAIQIHVSDNNydnnfGDILIFMTGQEDINATCYLLserfyevyESYK 724
Cdd:cd18791 1 FPVEVYYLEDIlellgissekeDPDYVDAAVRLILQIHRTEEP-----GDILVFLPGQEEIERLCELL--------REEL 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 725 ESKNNKKdtinkiknilnednnnnnndsnikkkvdgdnntndhmiypFYIFPIYSQLSSEQQSKIFKKYDL--RKIIVST 802
Cdd:cd18791 68 LSPDLGK----------------------------------------LLVLPLHSSLPPEEQQRVFEPPPPgvRKVVLAT 107
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1371546596 803 NIAETSLTLDGIKYVIDTGYCKLKVYNQTIGMDVLQVTPISQANANQRSGRAGRTGAGICYRLY 866
Cdd:cd18791 108 NIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
479-648 |
6.37e-57 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 194.20 E-value: 6.37e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRngiICCTQPRRVAAVSVAYRVSYEMNVDIGSLVGY 558
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH---IACTQPRRIACISLAKRVAFESLNQYGSKVAY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 559 TIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATIDAKK 638
Cdd:cd17979 78 QIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINIEL 157
|
170
....*....|
gi 1371546596 639 FSAFFGNAPI 648
Cdd:cd17979 158 FSGYFEGAPV 167
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
479-651 |
6.53e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 174.72 E-value: 6.53e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYE-----EGYHRNGIICCTQPRRVAAVSVAYRVSYEMNVDIG 553
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllnGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 554 -----SLVGYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLI 628
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170 180
....*....|....*....|...
gi 1371546596 629 VTSATIDAKKFSAFFGNAPIYNI 651
Cdd:cd17975 161 LMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
479-651 |
2.64e-49 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 172.72 E-value: 2.64e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRN-GIIC---CTQPRRVAAVSVAYRVSYEM--NVDI 552
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGkGSSCrivCTQPRRISAISVAERVAAERaeSCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 553 GSLVGYTIRFEDNTT-KDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTS 631
Cdd:cd17981 81 GNSTGYQIRLESRKPrKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 1371546596 632 ATIDAKKFSAFFGNAPIYNI 651
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
479-648 |
1.36e-47 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 167.70 E-value: 1.36e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYE---EGYHRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSL 555
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEyclSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 556 VGYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATID 635
Cdd:cd17977 81 VGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPHL 160
|
170
....*....|...
gi 1371546596 636 AKKFSAFFGNAPI 648
Cdd:cd17977 161 SSKLLSYYGNVPL 173
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
479-651 |
6.56e-46 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 163.08 E-value: 6.56e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYhRNGIIC---CTQPRRVAAVSVAYRVSYEMNVDIGSL 555
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCY-ANGIPCrifCTQPRRLAAIAVAERVAAERGEKIGQT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 556 VGYTIRFEDNTTKDTKIRYVTDGILLRETLN-DKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATI 634
Cdd:cd17987 80 VGYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAAL 159
|
170
....*....|....*..
gi 1371546596 635 DAKKFSAFFGNAPIYNI 651
Cdd:cd17987 160 DVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
454-648 |
6.02e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 162.31 E-value: 6.02e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 454 NIENNNKDKKNTLKDKEELLKLKESLPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEgYHRNGI-----IC 528
Cdd:cd17972 34 DLKNELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDD-FIQNDRaaecnIV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 529 CTQPRRVAAVSVAYRVSYEMNVDIGSLVGYTIRFEDNTTKD-TKIRYVTDGILLRETLNDkeLDKYSVIIMDEAHERSIN 607
Cdd:cd17972 113 VTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPhASILFCTVGVLLRKLEAG--IRGISHVIVDEIHERDIN 190
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1371546596 608 TDVLLGILKNICLKRNDLKLIVTSATIDAKKFSAFFGNAPI 648
Cdd:cd17972 191 TDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPV 231
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
479-651 |
6.59e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 157.31 E-value: 6.59e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGI----ICCTQPRRVAAVSVAYRVSYEMNVDIGS 554
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLpvanIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 555 LVGYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATI 634
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 1371546596 635 DAKKFSAFFGNAPIYNI 651
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
479-644 |
1.06e-41 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 151.12 E-value: 1.06e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGI--ICCTQPRRVAAVSVAYRVSYEMNVDIGSLV 556
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYcnIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 557 GYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNIcLKRND--LKLIVTSATI 634
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRL-LRTNSrhVKIILMSATI 159
|
170
....*....|
gi 1371546596 635 DAKKFSAFFG 644
Cdd:cd17988 160 SCKEFADYFT 169
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
479-648 |
6.77e-41 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 148.63 E-value: 6.77e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSVAYRVSYEMNVDIGSLVGY 558
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKIIVLEPRRVAARAAARRLATLLGEAPGETVGY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 559 TIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNI-CLKRNDLKLIVTSATIDAK 637
Cdd:cd17990 81 RVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVqQLLRDDLRLLAMSATLDGD 160
|
170
....*....|.
gi 1371546596 638 KFSAFFGNAPI 648
Cdd:cd17990 161 GLAALLPEAPV 171
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
479-651 |
9.03e-39 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 142.73 E-value: 9.03e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYN-NNIIIIVGETGSGKTTQIVQYLYEEGYHRN---GIICCTQPRRVAAVSVAYRVSYEMNVDIGS 554
Cdd:cd17986 1 LPIWAAKFTFLEQLESpSGIVLVSGEPGSGKSTQVPQWCAEFALSRGfqkGQVTVTQPHPLAARSLALRVADEMDLNLGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 555 LVGYTIRFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTSATI 634
Cdd:cd17986 81 EVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSPA 160
|
170
....*....|....*..
gi 1371546596 635 DAKKFSAFFGNAPIYNI 651
Cdd:cd17986 161 LEPKLRAFWGNPPVVHV 177
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
479-648 |
1.17e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 142.24 E-value: 1.17e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 479 LPIYKSKHELLDAVYNNNIIIIVGETGSGKTTQIVQYLYE------EGYHRNGIIccTQPRRVAAVSVAYRVSYEMNVDI 552
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdyvlrgRGARCNVVI--TQPRRISAVSVAQRVAHELGPNL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 553 GSLVGYTIRFEDN-TTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINTDVLLGILKNICLKRNDLKLIVTS 631
Cdd:cd17976 79 RRNVGYQVRLESRpPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMS 158
|
170
....*....|....*..
gi 1371546596 632 ATIDAKKFSAFFGNAPI 648
Cdd:cd17976 159 ATGDNQRLSRYFGGCPV 175
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
920-1008 |
2.57e-26 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 104.24 E-value: 2.57e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 920 SLHELWVLGAINNEGNLTDIGRKMVQFPLDPPLSKIVIYSQNFQCTKEILIIVSMLSSPSIFLES--------------- 984
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnfldprsaakaarrr 80
|
90 100
....*....|....*....|....
gi 1371546596 985 KENNESIESKKEKFTVPESDHLTL 1008
Cdd:pfam04408 81 RRAADEKARAKFARLDLEGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
927-1009 |
2.68e-26 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 103.12 E-value: 2.68e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 927 LGAINNEGNLTDIGRKMVQFPLDPPLSKIVIYSQNFQCTKEILIIVSMLSSPSIFleSKENNESIESKKEKFTVPESDHL 1006
Cdd:smart00847 2 LGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDHL 79
|
...
gi 1371546596 1007 TLL 1009
Cdd:smart00847 80 TLL 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
494-662 |
4.55e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 98.33 E-value: 4.55e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 494 NNNIIIIVGETGSGKTTQIVQYLYEEGYHRNGIIC-CTQPRRVAAVSVAYRVSYEM----NVDIGSLVGYTIR--FEDNT 566
Cdd:smart00487 23 GLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVlVLVPTRELAEQWAEELKKLGpslgLKVVGLYGGDSKReqLRKLE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 567 TKDTKIRYVTDGILLRETLNDK-ELDKYSVIIMDEAHERS--INTDVLLGILKnicLKRNDLKLIVTSATI--DAKKFSA 641
Cdd:smart00487 103 SGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLdgGFGDQLEKLLK---LLPKNVQLLLLSATPpeEIENLLE 179
|
170 180
....*....|....*....|.
gi 1371546596 642 FFGNAPIYNIQGRTFKVHIEY 662
Cdd:smart00487 180 LFLNDPVFIDVGFTPLEPIEQ 200
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
1066-1143 |
6.02e-20 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 85.00 E-value: 6.02e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 1066 IRKTICSGYFHNAAKLK-SFSEYINLRTNVSCHVHPNSSLYNI-GYTPDYVIYQEIVFTTKEYMRNVTTVDPEWLCELGP 1143
Cdd:pfam07717 1 LRAALAAGLYPNVARRDpKGKGYTTLSDNQRVFIHPSSVLFNEkTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
772-858 |
1.50e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 66.85 E-value: 1.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 772 FYIFPIYSQLSSEQQSKIFKKY--DLRKIIVSTNIAETSLTLDGIKYVIDTGYcklkvynqtigmdvlqvtPISQANANQ 849
Cdd:smart00490 12 IKVARLHGGLSQEEREEILDKFnnGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------PWSPASYIQ 73
|
....*....
gi 1371546596 850 RSGRAGRTG 858
Cdd:smart00490 74 RIGRAGRAG 82
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
499-633 |
1.41e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 57.80 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 499 IIVGETGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSVA--YRVSYEMNVDIGSLVGYT---IRFEdNTTKDTKIR 573
Cdd:cd00046 5 LITAPTGSGKTLAALLAALLLLLKKGKKVLVLVPTKALALQTAerLRELFGPGIRVAVLVGGSsaeEREK-NKLGDADII 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1371546596 574 YVTDGILLRETLNDK--ELDKYSVIIMDEAHERSINTDVLLGILKNICLKRN-DLKLIVTSAT 633
Cdd:cd00046 84 IATPDMLLNLLLREDrlFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLkNAQVILLSAT 146
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
774-858 |
3.10e-09 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 55.68 E-value: 3.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 774 IFPIYSQLSSEQQSKIFKKY--DLRKIIVSTNIAETSLTLDGIKYVIDTGYCKlkvynqtigmdvlqvtpiSQANANQRS 851
Cdd:pfam00271 41 VARLHGDLSQEEREEILEDFrkGKIDVLVATDVAERGLDLPDVDLVINYDLPW------------------NPASYIQRI 102
|
....*..
gi 1371546596 852 GRAGRTG 858
Cdd:pfam00271 103 GRAGRAG 109
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
447-867 |
1.49e-07 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 55.75 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 447 KIYSslfNIENNNKDKKNTLKDKEELLKLK-ESLPIyKSKHELLDAVYNNNIIIIVGETGSGKTTQI------VQYLYeE 519
Cdd:PHA02653 134 GIFS---NNVGSKKDTIGILGNPEPFSKIPlASLQP-DVQLKIFEAWISRKPVVLTGGTGVGKTSQVpklllwFNYLF-G 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 520 GYHRNGIICCT-QPR-------RVAAV---SVAYRVSYEMNVDIGSLVgyTIRFEDNTTKDTKIRYVTDGILL---RETL 585
Cdd:PHA02653 209 GFDNLDKIDPNfIERpivlslpRVALVrlhSITLLKSLGFDEIDGSPI--SLKYGSIPDELINTNPKPYGLVFsthKLTL 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 586 NdkELDKYSVIIMDEAHERSINTDVLLGIL-KNICLKRNdlkLIVTSATI--DAKKFSAFFGNAPIYNIQGRT-FKVHIE 661
Cdd:PHA02653 287 N--KLFDYGTVIIDEVHEHDQIGDIIIAVArKHIDKIRS---LFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPISEV 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 662 YLRTPCN-----DYIECAVQKAIQIhVSDNNYDNNFGDILIFMTgqediNATCyllserfyEVYESYKESKnnkkdtink 736
Cdd:PHA02653 362 YVKNKYNpknkrAYIEEEKKNIVTA-LKKYTPPKGSSGIVFVAS-----VSQC--------EEYKKYLEKR--------- 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 737 iknilnednnnnnndsnikkkvdgdnntndHMIYPFYIfpIYSQLSS--EQQSKIFKKYDLrKIIVSTNIAETSLTLDGI 814
Cdd:PHA02653 419 ------------------------------LPIYDFYI--IHGKVPNidEILEKVYSSKNP-SIIISTPYLESSVTIRNA 465
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 815 KYVIDTGycklKVY-------NQTIgmdvlqvtpISQANANQRSGRAGRTGAGICYRLYT 867
Cdd:PHA02653 466 THVYDTG----RVYvpepfggKEMF---------ISKSMRTQRKGRVGRVSPGTYVYFYD 512
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
489-635 |
7.35e-07 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 50.32 E-value: 7.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 489 LDAVYNNNIIIIVGETGSGKTT----QIVQYLYEEGYHRNGIICCtqPRRVAA---VSVAYRVSYEMNVDIGSLV-GYTI 560
Cdd:pfam00270 8 IPAILEGRDVLVQAPTGSGKTLafllPALEALDKLDNGPQALVLA--PTRELAeqiYEELKKLGKGLGLKVASLLgGDSR 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1371546596 561 RFEDNTTKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAHERSINT--DVLLGILKNIclkRNDLKLIVTSATID 635
Cdd:pfam00270 86 KEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRLLDMGfgPDLEEILRRL---PKKRQILLLSATLP 159
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
504-602 |
3.43e-05 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 45.23 E-value: 3.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 504 TGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSV-AYRVSYEMNVDIGSLvgytirfEDNTTKDTKIRYVTDGILLR 582
Cdd:cd17931 10 PGAGKTTRVLPQIIREAIKKRLRTLVLAPTRVVAAEMyEALRGLPIRYRTGAV-------KEEHGGNEIVDYMCHGTFTC 82
|
90 100
....*....|....*....|
gi 1371546596 583 ETLNDKELDKYSVIIMDEAH 602
Cdd:cd17931 83 RLLSPKRVPNYNLIIMDEAH 102
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
797-866 |
1.34e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 38.45 E-value: 1.34e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1371546596 797 KIIVSTNIAETSLTLDGIKYVIDTGYcklkvynqtigmdvlqvtPISQANANQRSGRAGRTG--AGICYRLY 866
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDP------------------PSSAASYIQRVGRAGRGGkdEGEVILFV 77
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
497-602 |
2.19e-03 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 39.25 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 497 IIIIVGETGSGKTTQIVQYLYEEGYHRNGIICCTQPRRVAAVSVAYrvsyemnvDIGSLVGYTIRFEDNTTKdtkiryvt 576
Cdd:pfam13401 7 ILVLTGESGTGKTTLLRRLLEQLPEVRDSVVFVDLPSGTSPKDLLR--------ALLRALGLPLSGRLSKEE-------- 70
|
90 100
....*....|....*....|....*...
gi 1371546596 577 dgilLRETLND--KELDKYSVIIMDEAH 602
Cdd:pfam13401 71 ----LLAALQQllLALAVAVVLIIDEAQ 94
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
494-602 |
2.52e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 39.96 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 494 NNNIIIIVGETGSGKT---TQIVQYLYEEGYHRNGIICCtqPRRvAAVSVAY----RVSYEMNVDIGSLVGYTIRFEDNT 566
Cdd:pfam04851 22 GQKRGLIVMATGSGKTltaAKLIARLFKKGPIKKVLFLV--PRK-DLLEQALeefkKFLPNYVEIGEIISGDKKDESVDD 98
|
90 100 110
....*....|....*....|....*....|....*.
gi 1371546596 567 TKDTKIRYVTDGILLRETLNDKELDKYSVIIMDEAH 602
Cdd:pfam04851 99 NKIVVTTIQSLYKALELASLELLPDFFDVIIIDEAH 134
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
495-631 |
6.36e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.51 E-value: 6.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1371546596 495 NNIIIIVGETGSGKTTQIVQYLYEEGYHRNGIIcctqprrvaavsvayrvsyemNVDIGSLVGYTIRFEDNTTKDTKIRY 574
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALARELGPPGGGVI---------------------YIDGEDILEEVLDQLLLIIVGGKKAS 60
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1371546596 575 VTDGILLRETLNDKELDKYSVIIMDEAH-------ERSINTDVLLGILKNIcLKRNDLKLIVTS 631
Cdd:smart00382 61 GSGELRLRLALALARKLKPDVLILDEITslldaeqEALLLLLEELRLLLLL-KSEKNLTVILTT 123
|
|
| |
