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Conserved domains on  [gi|1370962951|emb|SOS78987|]
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early transcribed membrane protein 10.2 [Plasmodium sp. gorilla clade G1]

Protein Classification

ETRAMP family protein( domain architecture ID 10019268)

ETRAMP family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ETRAMP TIGR01495
Plasmodium ring stage membrane protein ETRAMP; This model describes a family of proteins from ...
 1-89 2.63e-26

Plasmodium ring stage membrane protein ETRAMP; This model describes a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rident parasite Plasmodium yoelii. A homolog from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region, and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both P. falciparum and P. yoelii chromosomes


:

Pssm-ID: 130559  Cd Length: 85  Bit Score: 100.10  E-value: 2.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370962951   1 MKVGKIFFLLNILVVCHFIISCLCRNGQTTRGNlLALKAIEQdlQQKKKRKRNLILYSlGSAALIAALVVTGIGLNMYMK 80
Cdd:TIGR01495   1 MKVSKILYFFAALLAINFIAPGYCNNGKKVNKK-GNLKKLTK--AEKKKKNKKIILYS-SIASGLALLVGAGVGLGYYYK 76


                  ....*....
gi 1370962951  81 KKNVDSEVQ 89
Cdd:TIGR01495  77 KKNKDDEKL 85
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 199-304 5.86e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 38.74  E-value: 5.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370962951 199 ALADASEQNKNKDAESSTGqiptPTESSHGISDGKKDTSTNDMDPLNPYGSSKRNSSEDK------PTSESkgTTPESNF 272
Cdd:pfam05109 447 GLPSSTHVPTNLTAPASTG----PTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKapdmtsPTSAV--TTPTPNA 520

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1370962951 273 DSKTPEIKEINEPIIVPSYYPT------TGPNPNTHGP 304
Cdd:pfam05109 521 TSPTPAVTTPTPNATSPTLGKTsptsavTTPTPNATSP 558
 
Name Accession Description Interval E-value
ETRAMP TIGR01495
Plasmodium ring stage membrane protein ETRAMP; This model describes a family of proteins from ...
 1-89 2.63e-26

Plasmodium ring stage membrane protein ETRAMP; This model describes a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rident parasite Plasmodium yoelii. A homolog from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region, and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both P. falciparum and P. yoelii chromosomes


Pssm-ID: 130559  Cd Length: 85  Bit Score: 100.10  E-value: 2.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370962951   1 MKVGKIFFLLNILVVCHFIISCLCRNGQTTRGNlLALKAIEQdlQQKKKRKRNLILYSlGSAALIAALVVTGIGLNMYMK 80
Cdd:TIGR01495   1 MKVSKILYFFAALLAINFIAPGYCNNGKKVNKK-GNLKKLTK--AEKKKKNKKIILYS-SIASGLALLVGAGVGLGYYYK 76


                  ....*....
gi 1370962951  81 KKNVDSEVQ 89
Cdd:TIGR01495  77 KKNKDDEKL 85
ETRAMP pfam09716
Malarial early transcribed membrane protein (ETRAMP); These sequences represent a family of ...
 1-81 8.74e-22

Malarial early transcribed membrane protein (ETRAMP); These sequences represent a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rodent parasite Plasmodium yoelii. A homolog from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich, stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both Plasmodium falciparum and P. yoelii chromosomes.


Pssm-ID: 430768  Cd Length: 81  Bit Score: 88.06  E-value: 8.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370962951   1 MKVGKIFFLLNILVVCHFIISCLCRNGQTTRGNLLALKAIEQDLQQKKKRKRNLILYSLGSAALIAALVVTGIGLNMYMK 80
Cdd:pfam09716   1 MKLTKVLYFFAFLLAINLLTPCLCNNVVAKEKNKKALKKIDDKLEKKKKKKKIIIISSIASGLALLVATALGVGYYMKKK 80


                  .
gi 1370962951  81 K 81
Cdd:pfam09716  81 K 81
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 199-304 5.86e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 38.74  E-value: 5.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370962951 199 ALADASEQNKNKDAESSTGqiptPTESSHGISDGKKDTSTNDMDPLNPYGSSKRNSSEDK------PTSESkgTTPESNF 272
Cdd:pfam05109 447 GLPSSTHVPTNLTAPASTG----PTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKapdmtsPTSAV--TTPTPNA 520

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1370962951 273 DSKTPEIKEINEPIIVPSYYPT------TGPNPNTHGP 304
Cdd:pfam05109 521 TSPTPAVTTPTPNATSPTLGKTsptsavTTPTPNATSP 558
 
Name Accession Description Interval E-value
ETRAMP TIGR01495
Plasmodium ring stage membrane protein ETRAMP; This model describes a family of proteins from ...
 1-89 2.63e-26

Plasmodium ring stage membrane protein ETRAMP; This model describes a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rident parasite Plasmodium yoelii. A homolog from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region, and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both P. falciparum and P. yoelii chromosomes


Pssm-ID: 130559  Cd Length: 85  Bit Score: 100.10  E-value: 2.63e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370962951   1 MKVGKIFFLLNILVVCHFIISCLCRNGQTTRGNlLALKAIEQdlQQKKKRKRNLILYSlGSAALIAALVVTGIGLNMYMK 80
Cdd:TIGR01495   1 MKVSKILYFFAALLAINFIAPGYCNNGKKVNKK-GNLKKLTK--AEKKKKNKKIILYS-SIASGLALLVGAGVGLGYYYK 76


                  ....*....
gi 1370962951  81 KKNVDSEVQ 89
Cdd:TIGR01495  77 KKNKDDEKL 85
ETRAMP pfam09716
Malarial early transcribed membrane protein (ETRAMP); These sequences represent a family of ...
 1-81 8.74e-22

Malarial early transcribed membrane protein (ETRAMP); These sequences represent a family of proteins from the malaria parasite Plasmodium falciparum, several of which have been shown to be expressed specifically in the ring stage as well as the rodent parasite Plasmodium yoelii. A homolog from Plasmodium chabaudi was localized to the parasitophorous vacuole membrane. Members have an initial hydrophobic, Phe/Tyr-rich, stretch long enough to span the membrane, a highly charged region rich in Lys, a second putative transmembrane region and a second highly charged, low complexity sequence region. Some members have up to 100 residues of additional C-terminal sequence. These genes have been shown to be found in the sub-telomeric regions of both Plasmodium falciparum and P. yoelii chromosomes.


Pssm-ID: 430768  Cd Length: 81  Bit Score: 88.06  E-value: 8.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370962951   1 MKVGKIFFLLNILVVCHFIISCLCRNGQTTRGNLLALKAIEQDLQQKKKRKRNLILYSLGSAALIAALVVTGIGLNMYMK 80
Cdd:pfam09716   1 MKLTKVLYFFAFLLAINLLTPCLCNNVVAKEKNKKALKKIDDKLEKKKKKKKIIIISSIASGLALLVATALGVGYYMKKK 80


                  .
gi 1370962951  81 K 81
Cdd:pfam09716  81 K 81
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 199-304 5.86e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 38.74  E-value: 5.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370962951 199 ALADASEQNKNKDAESSTGqiptPTESSHGISDGKKDTSTNDMDPLNPYGSSKRNSSEDK------PTSESkgTTPESNF 272
Cdd:pfam05109 447 GLPSSTHVPTNLTAPASTG----PTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKapdmtsPTSAV--TTPTPNA 520

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1370962951 273 DSKTPEIKEINEPIIVPSYYPT------TGPNPNTHGP 304
Cdd:pfam05109 521 TSPTPAVTTPTPNATSPTLGKTsptsavTTPTPNATSP 558
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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