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Conserved domains on  [gi|1370516152|ref|XP_024308144|]
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DDB1- and CUL4-associated factor 8-like protein 2 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
SCOP:  4002744

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
224-540 4.10e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 4.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 224 LADHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPVLNFEsGHTNNVFQAKFLPNcgDSTLAMCARDGQVRVAELi 303
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASAD--GTYLASGSSDKTIRLWDL- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 304 nasyfNNTKCV---AQHRGPAHKLALEPDSPYkFLTSGEDAVVFTIDLRQDRPaskvvVTRENDKKVGLYTITVNPANTY 380
Cdd:cd00200    81 -----ETGECVrtlTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKC-----LTTLRGHTDWVNSVAFSPDGTF 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 381 QfAVGGQDQFVRIYDqrkidkKENNGVLKKFTPHhlvncdfPTNITCVVYSHDGTELLASYNDDDIYLFNssHSDGAQyS 460
Cdd:cd00200   150 V-ASSSQDGTIKLWD------LRTGKCVATLTGH-------TGEVNSVAFSPDGEKLLSSSSDGTIKLWD--LSTGKC-L 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 461 KRFKGHRNnttvkGVNF--YGPRSEFVVSGSDCGHIFFWEKSSCQIIQFLKGSrEGTINCLEPHPYLPVLACSGLDHDVK 538
Cdd:cd00200   213 GTLRGHEN-----GVNSvaFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIR 286

                  ..
gi 1370516152 539 IW 540
Cdd:cd00200   287 IW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
224-540 4.10e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 4.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 224 LADHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPVLNFEsGHTNNVFQAKFLPNcgDSTLAMCARDGQVRVAELi 303
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASAD--GTYLASGSSDKTIRLWDL- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 304 nasyfNNTKCV---AQHRGPAHKLALEPDSPYkFLTSGEDAVVFTIDLRQDRPaskvvVTRENDKKVGLYTITVNPANTY 380
Cdd:cd00200    81 -----ETGECVrtlTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKC-----LTTLRGHTDWVNSVAFSPDGTF 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 381 QfAVGGQDQFVRIYDqrkidkKENNGVLKKFTPHhlvncdfPTNITCVVYSHDGTELLASYNDDDIYLFNssHSDGAQyS 460
Cdd:cd00200   150 V-ASSSQDGTIKLWD------LRTGKCVATLTGH-------TGEVNSVAFSPDGEKLLSSSSDGTIKLWD--LSTGKC-L 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 461 KRFKGHRNnttvkGVNF--YGPRSEFVVSGSDCGHIFFWEKSSCQIIQFLKGSrEGTINCLEPHPYLPVLACSGLDHDVK 538
Cdd:cd00200   213 GTLRGHEN-----GVNSvaFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIR 286

                  ..
gi 1370516152 539 IW 540
Cdd:cd00200   287 IW 288
WD40 COG2319
WD40 repeat [General function prediction only];
219-540 5.99e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 5.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 219 RLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPVLNFeSGHTNNVFQAKFLPNcgDSTLAMCARDGQVR 298
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPD--GKLLASGSDDGTVR 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 299 VAELinasyfNNTKCVAQ---HRGPAHKLALEPDSpyKFL-TSGEDAVVFTIDLRQDRPaskvvVTRENDKKVGLYTITV 374
Cdd:COG2319   188 LWDL------ATGKLLRTltgHTGAVRSVAFSPDG--KLLaSGSADGTVRLWDLATGKL-----LRTLTGHSGSVRSVAF 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 375 NPANTYqFAVGGQDQFVRIYDQrkidkkeNNGVLKKFTPHHlvncdfPTNITCVVYSHDGTELLASYNDDDIYLFNsshS 454
Cdd:COG2319   255 SPDGRL-LASGSADGTVRLWDL-------ATGELLRTLTGH------SGGVNSVAFSPDGKLLASGSDDGTVRLWD---L 317
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 455 DGAQYSKRFKGHRNntTVKGVNFyGPRSEFVVSGSDCGHIFFWEKSSCQIIQFLKGsREGTINCLEPHPYLPVLACSGLD 534
Cdd:COG2319   318 ATGKLLRTLTGHTG--AVRSVAF-SPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSAD 393

                  ....*.
gi 1370516152 535 HDVKIW 540
Cdd:COG2319   394 GTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
218-256 1.90e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.90e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1370516152  218 FRLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWD 256
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
218-256 2.07e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1370516152 218 FRLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWD 256
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
224-540 4.10e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 4.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 224 LADHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPVLNFEsGHTNNVFQAKFLPNcgDSTLAMCARDGQVRVAELi 303
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGPVRDVAASAD--GTYLASGSSDKTIRLWDL- 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 304 nasyfNNTKCV---AQHRGPAHKLALEPDSPYkFLTSGEDAVVFTIDLRQDRPaskvvVTRENDKKVGLYTITVNPANTY 380
Cdd:cd00200    81 -----ETGECVrtlTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKC-----LTTLRGHTDWVNSVAFSPDGTF 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 381 QfAVGGQDQFVRIYDqrkidkKENNGVLKKFTPHhlvncdfPTNITCVVYSHDGTELLASYNDDDIYLFNssHSDGAQyS 460
Cdd:cd00200   150 V-ASSSQDGTIKLWD------LRTGKCVATLTGH-------TGEVNSVAFSPDGEKLLSSSSDGTIKLWD--LSTGKC-L 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 461 KRFKGHRNnttvkGVNF--YGPRSEFVVSGSDCGHIFFWEKSSCQIIQFLKGSrEGTINCLEPHPYLPVLACSGLDHDVK 538
Cdd:cd00200   213 GTLRGHEN-----GVNSvaFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIR 286

                  ..
gi 1370516152 539 IW 540
Cdd:cd00200   287 IW 288
WD40 COG2319
WD40 repeat [General function prediction only];
219-540 5.99e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 5.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 219 RLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPVLNFeSGHTNNVFQAKFLPNcgDSTLAMCARDGQVR 298
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPD--GKLLASGSDDGTVR 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 299 VAELinasyfNNTKCVAQ---HRGPAHKLALEPDSpyKFL-TSGEDAVVFTIDLRQDRPaskvvVTRENDKKVGLYTITV 374
Cdd:COG2319   188 LWDL------ATGKLLRTltgHTGAVRSVAFSPDG--KLLaSGSADGTVRLWDLATGKL-----LRTLTGHSGSVRSVAF 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 375 NPANTYqFAVGGQDQFVRIYDQrkidkkeNNGVLKKFTPHHlvncdfPTNITCVVYSHDGTELLASYNDDDIYLFNsshS 454
Cdd:COG2319   255 SPDGRL-LASGSADGTVRLWDL-------ATGELLRTLTGH------SGGVNSVAFSPDGKLLASGSDDGTVRLWD---L 317
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 455 DGAQYSKRFKGHRNntTVKGVNFyGPRSEFVVSGSDCGHIFFWEKSSCQIIQFLKGsREGTINCLEPHPYLPVLACSGLD 534
Cdd:COG2319   318 ATGKLLRTLTGHTG--AVRSVAF-SPDGKTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSAD 393

                  ....*.
gi 1370516152 535 HDVKIW 540
Cdd:COG2319   394 GTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
211-552 1.14e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 1.14e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 211 ARAFVQRFRLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWDwVRQRPVLNFESGHTNNVFQAKFLPNcgDSTLAM 290
Cdd:COG2319    61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSPD--GKTLAS 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 291 CARDGQVRVAELinasyfNNTKCVAQ---HRGPAHKLALEPDSpyKFL-TSGEDAVVFTIDLRQDRPaskvvVTRENDKK 366
Cdd:COG2319   138 GSADGTVRLWDL------ATGKLLRTltgHSGAVTSVAFSPDG--KLLaSGSDDGTVRLWDLATGKL-----LRTLTGHT 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 367 VGLYTITVNPANTYqFAVGGQDQFVRIYDqrkidkkENNGVLKKFTPHHlvncdfPTNITCVVYSHDGTELLASYNDDDI 446
Cdd:COG2319   205 GAVRSVAFSPDGKL-LASGSADGTVRLWD-------LATGKLLRTLTGH------SGSVRSVAFSPDGRLLASGSADGTV 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 447 YLFNsshSDGAQYSKRFKGHRNntTVKGVNFyGPRSEFVVSGSDCGHIFFWEKSSCQIIQFLKGsREGTINCLEPHPYLP 526
Cdd:COG2319   271 RLWD---LATGELLRTLTGHSG--GVNSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGK 343
                         330       340
                  ....*....|....*....|....*..
gi 1370516152 527 VLACSGLDHDVKIW-TPTAKAATELTG 552
Cdd:COG2319   344 TLASGSDDGTVRLWdLATGELLRTLTG 370
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
317-546 3.71e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 3.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 317 HRGPAHKLALEPDSPYkFLTSGEDAVVFTIDLRQDRpaskvVVTRENDKKVGLYTITVNPANTYqFAVGGQDQFVRIYDq 396
Cdd:cd00200     8 HTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWD- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 397 rkidkKENNGVLKKFTPHhlvncdfPTNITCVVYSHDGTELLASYNDDDIYLFNSshsDGAQYSKRFKGHRNntTVKGVN 476
Cdd:cd00200    80 -----LETGECVRTLTGH-------TSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTD--WVNSVA 142
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 477 FyGPRSEFVVSGSDCGHIFFWEKSSCQIIQFLKGSrEGTINCLEPHPYLPVLACSGLDHDVKIWTPTAKA 546
Cdd:cd00200   143 F-SPDGTFVASSSQDGTIKLWDLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210
WD40 COG2319
WD40 repeat [General function prediction only];
215-450 2.72e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 2.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 215 VQRFRLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPVLNFEsGHTNNVFQAKFLPNcgDSTLAMCARD 294
Cdd:COG2319   191 LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPD--GRLLASGSAD 267
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 295 GQVRVAELinasyfNNTKCVA---QHRGPAHKLALEPDSPYkFLTSGEDAVVFTIDLRQDRPaskvvVTRENDKKVGLYT 371
Cdd:COG2319   268 GTVRLWDL------ATGELLRtltGHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLATGKL-----LRTLTGHTGAVRS 335
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370516152 372 ITVNPANTyQFAVGGQDQFVRIYDqrkidkKENNGVLKKFTPHhlvncdfPTNITCVVYSHDGTELLASYNDDDIYLFN 450
Cdd:COG2319   336 VAFSPDGK-TLASGSDDGTVRLWD------LATGELLRTLTGH-------TGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
215-395 2.38e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 2.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 215 VQRFRLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWDWVRQRPVLNFEsGHTNNVFQAKFLPNcgDSTLAMCARD 294
Cdd:cd00200   122 VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPD--GEKLLSSSSD 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370516152 295 GQVRVAELinasyfNNTKCVAQ---HRGPAHKLALEPDSpyKFLTSG-EDAVVFTIDLRQDRPASKVVVTREndkkvGLY 370
Cdd:cd00200   199 GTIKLWDL------STGKCLGTlrgHENGVNSVAFSPDG--YLLASGsEDGTIRVWDLRTGECVQTLSGHTN-----SVT 265
                         170       180
                  ....*....|....*....|....*
gi 1370516152 371 TITVNPANTYqFAVGGQDQFVRIYD 395
Cdd:cd00200   266 SLAWSPDGKR-LASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
218-256 1.90e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.90e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1370516152  218 FRLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWD 256
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
218-256 2.07e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1370516152 218 FRLQYRLADHVGCVNTVHFNQRGTRLASSGDDLKVIVWD 256
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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