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Conserved domains on  [gi|1370509367|ref|XP_024302396|]
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actin-related protein 2/3 complex subunit 1B isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 1.23e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 1.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  15 AWNKDRTQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgRTWKPTLVILR 94
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  95 INRAARCVRWAPNENKFAVGSGSRVISIcyfeqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLatgkLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367 171 AyikeveerpaptpwgskmPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAL 250
Cdd:COG2319   275 L------------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         250
                  ....*....|....
gi 1370509367 251 TFITDNSLVAAGHD 264
Cdd:COG2319   337 AFSPDGKTLASGSD 350
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 1.23e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 1.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  15 AWNKDRTQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgRTWKPTLVILR 94
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  95 INRAARCVRWAPNENKFAVGSGSRVISIcyfeqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLatgkLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367 171 AyikeveerpaptpwgskmPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAL 250
Cdd:COG2319   275 L------------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         250
                  ....*....|....
gi 1370509367 251 TFITDNSLVAAGHD 264
Cdd:COG2319   337 AFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-264 8.04e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 8.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  45 VHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRInrAARCVRWAPNENKFAVGSGSRVISIcy 124
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367 125 feqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS-AYIKEVEERPAPTPWGSKMPF-GELMFES 198
Cdd:cd00200    78 ------WDLetgeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAFsPDGTFVA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367 199 SSSC----------------------GWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDN 256
Cdd:cd00200   152 SSSQdgtiklwdlrtgkcvatltghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231


                  ....*...
gi 1370509367 257 SLVAAGHD 264
Cdd:cd00200   232 YLLASGSE 239
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-79 4.23e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.23e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1370509367   41 KWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
42-79 5.25e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 5.25e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1370509367  42 WTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 1.23e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 1.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  15 AWNKDRTQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgRTWKPTLVILR 94
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTG 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  95 INRAARCVRWAPNENKFAVGSGSRVISIcyfeqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319   203 HTGAVRSVAFSPDGKLLASGSADGTVRL--------WDLatgkLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367 171 AyikeveerpaptpwgskmPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAL 250
Cdd:COG2319   275 L------------------ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         250
                  ....*....|....
gi 1370509367 251 TFITDNSLVAAGHD 264
Cdd:COG2319   337 AFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
15-262 4.00e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 4.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  15 AWNKDRTQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVilR 94
Cdd:COG2319   169 AFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--G 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  95 INRAARCVRWAPNENKFAVGSGSRVISICyfeqENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAyik 174
Cdd:COG2319   245 HSGSVRSVAFSPDGRLLASGSADGTVRLW----DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL--- 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367 175 eveerpaptpwgskmPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFIT 254
Cdd:COG2319   318 ---------------ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382


                  ....*...
gi 1370509367 255 DNSLVAAG 262
Cdd:COG2319   383 DGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
15-264 2.27e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 2.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  15 AWNKDRTQIAICPNNHEVHIYEKSGAKWtkVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgRTWKPTLVILR 94
Cdd:COG2319    85 AFSPDGRLLASASADGTVRLWDLATGLL--LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--ATGKLLRTLTG 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  95 INRAARCVRWAPNENKFAVGSGSRVISIcyfeqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS 170
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRL--------WDLatgkLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367 171 ayikeveerpAPTpwgskmpfGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLAL 250
Cdd:COG2319   233 ----------LAT--------GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294

                         250
                  ....*....|....
gi 1370509367 251 TFITDNSLVAAGHD 264
Cdd:COG2319   295 AFSPDGKLLASGSD 308
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-264 8.04e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 8.04e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  45 VHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRInrAARCVRWAPNENKFAVGSGSRVISIcy 124
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG--PVRDVAASADGTYLASGSSDKTIRL-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367 125 feqendWWV----CKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFS-AYIKEVEERPAPTPWGSKMPF-GELMFES 198
Cdd:cd00200    78 ------WDLetgeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDvETGKCLTTLRGHTDWVNSVAFsPDGTFVA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367 199 SSSC----------------------GWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDN 256
Cdd:cd00200   152 SSSQdgtiklwdlrtgkcvatltghtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231


                  ....*...
gi 1370509367 257 SLVAAGHD 264
Cdd:cd00200   232 YLLASGSE 239
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-265 2.94e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 2.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367   4 HSFLVEPISCHAwnkDRTQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkg 83
Cdd:cd00200    50 HTGPVRDVAASA---DGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-- 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  84 RTWKPTLVILRINRAARCVRWAPNeNKFAVGSGS-RVISICyfeqENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSC 162
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQdGTIKLW----DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367 163 DFKCRIFSAYikeveerpaptpwgSKMPFGELmfesSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLAS 242
Cdd:cd00200   198 DGTIKLWDLS--------------TGKCLGTL----RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                         250       260
                  ....*....|....*....|....
gi 1370509367 243 ETLPLLALTFITDNS-LVAAGHDC 265
Cdd:cd00200   260 HTNSVTSLAWSPDGKrLASGSADG 283
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-226 2.90e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.29  E-value: 2.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367   9 EPISCHAWNKDRTQIAICPNNHEVHIYEksGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLkgRTWKP 88
Cdd:cd00200    94 SYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL--RTGKC 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  89 TLVILRINRAARCVRWAPNENKFAVGSGSRVISIcyFEQENDWWVCKHIKKpiRSTVLSLDWHPNNVLLAAGSCDFKCRI 168
Cdd:cd00200   170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL--WDLSTGKCLGTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRV 245

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370509367 169 FSAYIkeveerpaptpwgskmpfGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTV 226
Cdd:cd00200   246 WDLRT------------------GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-170 3.36e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 3.36e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  10 PISCHAWNKDRTQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPT 89
Cdd:cd00200   137 WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  90 LVilRINRAARCVRWAPNENKFAVGSGSRVISIcyfeqendW-WVCKHIKKPIR---STVLSLDWHPNNVLLAAGSCDFK 165
Cdd:cd00200   215 LR--GHENGVNSVAFSPDGYLLASGSEDGTIRV--------WdLRTGECVQTLSghtNSVTSLAWSPDGKRLASGSADGT 284


                  ....*
gi 1370509367 166 CRIFS 170
Cdd:cd00200   285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
15-163 1.67e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 1.67e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  15 AWNKDRTQIAICPNNHEVHIYEKSGAKWtkVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKgrTWKPTLVILR 94
Cdd:COG2319   253 AFSPDGRLLASGSADGTVRLWDLATGEL--LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTG 328

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370509367  95 INRAARCVRWAPNENKFAVGSGSRVISIcyfeqendW----WVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCD 163
Cdd:COG2319   329 HTGAVRSVAFSPDGKTLASGSDDGTVRL--------WdlatGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-79 4.23e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.23e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1370509367   41 KWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
59-264 4.47e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 4.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367  59 DWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRinRAARCVRWAPNENKFAVGSGSRVISIcyfeQENDWWVCKHIK 138
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLA--AAVASLAASPDGARLAAGAGDLTLLL----LDAAAGALLATL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370509367 139 KPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAyikeVEERPAPTPWGSKmpfgelmfesssscGWVHGVCFSASGSRVA 218
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDL----ATGLLLRTLTGHT--------------GAVRSVAFSPDGKTLA 136

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1370509367 219 WVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHD 264
Cdd:COG2319   137 SGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182
WD40 pfam00400
WD domain, G-beta repeat;
42-79 5.25e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 5.25e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1370509367  42 WTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
15-83 4.12e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 4.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370509367  15 AWNKDRTQIAICPNNHEVHIYEKSGAKwtKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKG 83
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-79 5.02e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 5.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370509367   9 EPISCHAWNKDRTQIAICPNNHEVHIYekSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVW 79
Cdd:cd00200   220 NGVNSVAFSPDGYLLASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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