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Conserved domains on  [gi|1370508615|ref|XP_024302306|]
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zinc finger and SCAN domain-containing protein 26 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCAN super family cl42860
leucine rich region;
23-129 9.36e-51

leucine rich region;


The actual alignment was detected with superfamily member smart00431:

Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 167.48  E-value: 9.36e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615   23 KQFRQLRYEETTGPREALSRLRELCQQWLQPETHTKEQILELLVLEQFLIILPKELQARVQEHHPESREDVVVVLEDLQL 102
Cdd:smart00431   6 QRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLEDLER 85

                           90       100
                   ....*....|....*....|....*..
gi 1370508615  103 DLGETGQQVdPDQPKKQKILVEEMAPL 129
Cdd:smart00431  86 ELDEPGQQV-SAHVHGQEVLLEKMVPL 111
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
261-440 1.04e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 261 KAFQRSSHLVRHQKIHLG-EKPYQCNECGKVFSQNAGLLEHLR--IHTGE--KPYLCIH--CGKNFRRSSHLNRHQRIHS 333
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 334 QEEPCECK--ECGKTFSQAL-----LLTHHQRIHSHSKSHQC--NECGKAFSLTSDLIRHHRIHTGEKP--FKCNICQKA 402
Cdd:COG5048   348 SISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370508615 403 FRLNSHLAQHVRIHNEEKPYQCSECGeAFRQRSGLFQH 440
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDLSNH 464
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
23-129 9.36e-51

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 167.48  E-value: 9.36e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615   23 KQFRQLRYEETTGPREALSRLRELCQQWLQPETHTKEQILELLVLEQFLIILPKELQARVQEHHPESREDVVVVLEDLQL 102
Cdd:smart00431   6 QRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLEDLER 85

                           90       100
                   ....*....|....*....|....*..
gi 1370508615  103 DLGETGQQVdPDQPKKQKILVEEMAPL 129
Cdd:smart00431  86 ELDEPGQQV-SAHVHGQEVLLEKMVPL 111
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 18-106 5.25e-43

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 146.48  E-value: 5.25e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615  18 QEPLCKQFRQLRYEETTGPREALSRLRELCQQWLQPETHTKEQILELLVLEQFLIILPKELQARVQEHHPESREDVVVVL 97
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 1370508615  98 EDLQLDLGE 106
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 23-101 5.11e-34

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 122.37  E-value: 5.11e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370508615  23 KQFRQLRYEETTGPREALSRLRELCQQWLQPETHTKEQILELLVLEQFLIILPKELQARVQEHHPESREDVVVVLEDLQ 101
Cdd:cd07936     6 QRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLAEDLL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
261-440 1.04e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 261 KAFQRSSHLVRHQKIHLG-EKPYQCNECGKVFSQNAGLLEHLR--IHTGE--KPYLCIH--CGKNFRRSSHLNRHQRIHS 333
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 334 QEEPCECK--ECGKTFSQAL-----LLTHHQRIHSHSKSHQC--NECGKAFSLTSDLIRHHRIHTGEKP--FKCNICQKA 402
Cdd:COG5048   348 SISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370508615 403 FRLNSHLAQHVRIHNEEKPYQCSECGeAFRQRSGLFQH 440
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-293 2.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.80e-04
                          10        20
                  ....*....|....*....|....*.
gi 1370508615 268 HLVRHQKIHLGEKPYQCNECGKVFSQ 293
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
23-129 9.36e-51

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 167.48  E-value: 9.36e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615   23 KQFRQLRYEETTGPREALSRLRELCQQWLQPETHTKEQILELLVLEQFLIILPKELQARVQEHHPESREDVVVVLEDLQL 102
Cdd:smart00431   6 QRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLEDLER 85

                           90       100
                   ....*....|....*....|....*..
gi 1370508615  103 DLGETGQQVdPDQPKKQKILVEEMAPL 129
Cdd:smart00431  86 ELDEPGQQV-SAHVHGQEVLLEKMVPL 111
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 18-106 5.25e-43

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 146.48  E-value: 5.25e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615  18 QEPLCKQFRQLRYEETTGPREALSRLRELCQQWLQPETHTKEQILELLVLEQFLIILPKELQARVQEHHPESREDVVVVL 97
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 1370508615  98 EDLQLDLGE 106
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 23-101 5.11e-34

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 122.37  E-value: 5.11e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370508615  23 KQFRQLRYEETTGPREALSRLRELCQQWLQPETHTKEQILELLVLEQFLIILPKELQARVQEHHPESREDVVVVLEDLQ 101
Cdd:cd07936     6 QRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLAEDLL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
261-440 1.04e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 261 KAFQRSSHLVRHQKIHLG-EKPYQCNECGKVFSQNAGLLEHLR--IHTGE--KPYLCIH--CGKNFRRSSHLNRHQRIHS 333
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 334 QEEPCECK--ECGKTFSQAL-----LLTHHQRIHSHSKSHQC--NECGKAFSLTSDLIRHHRIHTGEKP--FKCNICQKA 402
Cdd:COG5048   348 SISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1370508615 403 FRLNSHLAQHVRIHNEEKPYQCSECGeAFRQRSGLFQH 440
Cdd:COG5048   428 FNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
201-407 1.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 201 IEYKCSEREQRFIQHLDLIEHASTHTGKKLCESDVC-QSSSLTGHKKVLSREKG-----HQCHECGKAFQRSSHLVRHQ- 273
Cdd:COG5048   231 TNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPtASSQSSSPNESDSSSEKgfslpIKSKQCNISFSRSSPLTRHLr 310

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 274 -KIHLGE--KPYQCNE--CGKVFSQNAGLLEHLRIHTGEKPYLCI--HCGKNFRRSSHLNRHQRIHSQEEPCECKE---- 342
Cdd:COG5048   311 sVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetl 390

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 343 ---CGKTFSQALLLTHHQRIHSHSKSHQCN--ECGKAFSLTSDLIRHHRIHTGEKPFKCNICQKAFRLNS 407
Cdd:COG5048   391 snsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
238-427 3.81e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 3.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 238 SSSLTGHKKVLSREKGHQCHECGKAFQRSSHLVRHQKIHLGEKPYQCN--ECGKVFSQNAGLLEHLRIHTGEKPYLCIHC 315
Cdd:COG5048    18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 316 GK--NFRRSSHLNRHQRIHSQE-EPCECKECGKTFSQALLLTHHQRIHSHSKS-HQCNECGKAFSLTSDLI--------- 382
Cdd:COG5048    98 LPlsNSKASSSSLSSSSSNSNDnNLLSSHSLPPSSRDPQLPDLLSISNLRNNPlPGNNSSSVNTPQSNSLHpplpansls 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370508615 383 ----------RHHRIHTGEKPFKCNICQKAFRLNSHLAQHVRIHNEEKPYQCSEC 427
Cdd:COG5048   178 kdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN 232
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
392-449 1.63e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370508615 392 KPFKCNICQKAFRLNSHLAQHVRIHNEEKPYQCSECGEAFRQRSG--LFQHQRYHHKDKL 449
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-293 2.80e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.80e-04
                          10        20
                  ....*....|....*....|....*.
gi 1370508615 268 HLVRHQKIHLGEKPYQCNECGKVFSQ 293
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
380-403 1.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|....
gi 1370508615 380 DLIRHHRIHTGEKPFKCNICQKAF 403
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-433 2.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.52e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370508615 408 HLAQHVRIHNEEKPYQCSECGEAFRQ 433
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 254-276 2.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.83e-03
                          10        20
                  ....*....|....*....|...
gi 1370508615 254 HQCHECGKAFQRSSHLVRHQKIH 276
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-321 3.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.10e-03
                          10        20
                  ....*....|....*....|....*
gi 1370508615 297 LLEHLRIHTGEKPYLCIHCGKNFRR 321
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 390-445 3.66e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.66e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370508615 390 GEKPFKCNI--CQKAF---------RLNSHLAQ----------HVRIHNEEKPYQCSECGEAFRQRSGLFQHQRYHH 445
Cdd:COG5189   346 DGKPYKCPVegCNKKYknqnglkyhMLHGHQNQklhenpspekMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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