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Conserved domains on  [gi|1370487057|ref|XP_024309858|]
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pituitary homeobox 2 isoform X1 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11079034)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes; also contains an OAR domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
2-31 1.30e-13

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 62.90  E-value: 1.30e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 1370487057   2 STREEIAVWTNLTEARVRVWFKNRRAKWRK 31
Cdd:pfam00046  28 EEREELAAQLGLTERQVKVWFQNRRAKWKR 57
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 164-181 1.61e-06

OAR motif; The entry represents the OAR motif.


:

Pssm-ID: 461067  Cd Length: 19  Bit Score: 43.17  E-value: 1.61e-06
                          10
                  ....*....|....*...
gi 1370487057 164 DTCNSSLASLRLKAKQHS 181
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
2-31 1.30e-13

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 62.90  E-value: 1.30e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 1370487057   2 STREEIAVWTNLTEARVRVWFKNRRAKWRK 31
Cdd:pfam00046  28 EEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2-33 3.56e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 56.48  E-value: 3.56e-11
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1370487057   2 STREEIAVWTNLTEARVRVWFKNRRAKWRKRE 33
Cdd:cd00086    28 EEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 3-30 2.92e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.79  E-value: 2.92e-10
                           10        20
                   ....*....|....*....|....*...
gi 1370487057    3 TREEIAVWTNLTEARVRVWFKNRRAKWR 30
Cdd:smart00389  30 EREELAKKLGLSERQVKVWFQNRRAKWK 57
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 164-181 1.61e-06

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 43.17  E-value: 1.61e-06
                          10
                  ....*....|....*...
gi 1370487057 164 DTCNSSLASLRLKAKQHS 181
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
3-31 4.08e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 36.26  E-value: 4.08e-03
                          10        20
                  ....*....|....*....|....*....
gi 1370487057   3 TREEIAVWTNLTEARVRVWFKNRRAKWRK 31
Cdd:COG5576    80 TRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
2-31 1.30e-13

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 62.90  E-value: 1.30e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 1370487057   2 STREEIAVWTNLTEARVRVWFKNRRAKWRK 31
Cdd:pfam00046  28 EEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2-33 3.56e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 56.48  E-value: 3.56e-11
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1370487057   2 STREEIAVWTNLTEARVRVWFKNRRAKWRKRE 33
Cdd:cd00086    28 EEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 3-30 2.92e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 53.79  E-value: 2.92e-10
                           10        20
                   ....*....|....*....|....*...
gi 1370487057    3 TREEIAVWTNLTEARVRVWFKNRRAKWR 30
Cdd:smart00389  30 EREELAKKLGLSERQVKVWFQNRRAKWK 57
OAR pfam03826
OAR motif; The entry represents the OAR motif.
 164-181 1.61e-06

OAR motif; The entry represents the OAR motif.


Pssm-ID: 461067  Cd Length: 19  Bit Score: 43.17  E-value: 1.61e-06
                          10
                  ....*....|....*...
gi 1370487057 164 DTCNSSLASLRLKAKQHS 181
Cdd:pfam03826   1 DRRSSSIASLRLKAKEHS 18
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
3-31 4.08e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 36.26  E-value: 4.08e-03
                          10        20
                  ....*....|....*....|....*....
gi 1370487057   3 TREEIAVWTNLTEARVRVWFKNRRAKWRK 31
Cdd:COG5576    80 TRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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