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Conserved domains on  [gi|1370463642|ref|XP_024305087|]
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purine nucleoside phosphorylase LACC1 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cu-oxidase_4 super family cl47752
Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able ...
 195-303 4.33e-26

Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.


The actual alignment was detected with superfamily member pfam02578:

Pssm-ID: 460601 [Multi-domain]  Cd Length: 232  Bit Score: 103.34  E-value: 4.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463642 195 TTRTGGISYIP--------TlssfnlfssskRRDPKVVVQENLRRLANAAGFNVEKFYRIKTHHSNDIWIM-----GRKE 261
Cdd:pfam02578   1 TTRLGGVSEGPyaslnlglH-----------VGDDPEAVAENRRRLAAALGLPPERLVWLRQVHGTDVRVVteddaGAAR 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1370463642 262 PDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAG 303
Cdd:pfam02578  70 EEDADALVTDEPGVALAVLTADCVPVLLADPVGGVVAAAHAG 111
 
Name Accession Description Interval E-value
Cu-oxidase_4 pfam02578
Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able ...
 195-303 4.33e-26

Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.


Pssm-ID: 460601 [Multi-domain]  Cd Length: 232  Bit Score: 103.34  E-value: 4.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463642 195 TTRTGGISYIP--------TlssfnlfssskRRDPKVVVQENLRRLANAAGFNVEKFYRIKTHHSNDIWIM-----GRKE 261
Cdd:pfam02578   1 TTRLGGVSEGPyaslnlglH-----------VGDDPEAVAENRRRLAAALGLPPERLVWLRQVHGTDVRVVteddaGAAR 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1370463642 262 PDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAG 303
Cdd:pfam02578  70 EEDADALVTDEPGVALAVLTADCVPVLLADPVGGVVAAAHAG 111
YfiH COG1496
Copper oxidase (laccase) domain [Inorganic ion transport and metabolism];
187-303 7.23e-22

Copper oxidase (laccase) domain [Inorganic ion transport and metabolism];


Pssm-ID: 441105 [Multi-domain]  Cd Length: 246  Bit Score: 92.16  E-value: 7.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463642 187 PDIFIHGFTTRTGGISYIP-------TlssfnlfsssKRRDPKVVVQENLRRLANAAGFNVEKFYRIKTHHSNDIWIMGR 259
Cdd:COG1496     9 PPGVRHGFTTRLGGVSQGPydslnlgL----------HVGDDPEAVAENRRRLAAALGLPPDRLVWLNQVHGTRVVVVDA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1370463642 260 KEPDSY----DGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAG 303
Cdd:COG1496    79 PDPDGAipeaDALVTNEPGVALAVLTADCVPVLFADPEGGVVAAAHAG 126
YfiH cd16833
protein of unknown function YfiH; This subfamily contains YfiH, a protein of unknown function ...
 250-303 3.57e-14

protein of unknown function YfiH; This subfamily contains YfiH, a protein of unknown function from Shigella flexneri, E. coli, and many similar proteins which collectively are often called DUF152. The structure of YfiH reveals a distant homology to Rho-activating toxins cytotoxic necrotizing factor 1 (CNF1) as well as chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs), all having an invariant Cys-His pair forming a catalytic dyad, and is required by the CNF-1 toxins for deamidation activity.


Pssm-ID: 319354  Cd Length: 185  Bit Score: 69.54  E-value: 3.57e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370463642 250 HSNDI----WIMGRKEPDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAG 303
Cdd:cd16833     9 HGVRVvdvdDAGGGTAIPEADALITNEPGVALAVLTADCVPVLLYDPKGGVIAAAHAG 66
TIGR00726 TIGR00726
YfiH family protein; PSI-BLAST converges on members of this family of uncharacterized ...
 220-303 7.94e-10

YfiH family protein; PSI-BLAST converges on members of this family of uncharacterized bacterial proteins and shows no significant similarity to any characterized protein. No completed genome to date has two members. Members of the family have been crystallized but the function is unknown. [Unknown function, General]


Pssm-ID: 273235 [Multi-domain]  Cd Length: 221  Bit Score: 57.78  E-value: 7.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463642 220 DPKVVVQENLRRLANAAGFnVEKFYRIKTHHSNDIwimgRKEPDSY------DGITTNQRGVTIAALGADCIPIVFADPV 293
Cdd:TIGR00726  18 DNKAFVLANRERLIAYFNL-PNKIVWLKQVHGDRV----LKVTDKDstlpeaDGLITNTPNLVLAVYTADCVPVLFYDRV 92

                          90
                  ....*....|
gi 1370463642 294 KKACGVAHAG 303
Cdd:TIGR00726  93 GKIVAAVHAG 102
PRK10723 PRK10723
polyphenol oxidase;
195-303 2.39e-04

polyphenol oxidase;


Pssm-ID: 182677  Cd Length: 243  Bit Score: 41.93  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463642 195 TTRTGGISYIPTLSSFNLFSSSkrrDPKVVVQENLRRLANAAGFNVEKFYRIKTHHSNDIWIMGrKEPDSY--DGITTNQ 272
Cdd:PRK10723   20 STRIGGVSLPPYDSLNLGAHCG---DNPDHVEENRKRLFAAANLPSKPVWLEQVHGTDVLRLTG-EPYASKraDASYSNT 95

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1370463642 273 RGVTIAALGADCIPIVFADPVKKACGVAHAG 303
Cdd:PRK10723   96 PGTVCAVMTADCLPVLFCNRAGTEVAAAHAG 126
 
Name Accession Description Interval E-value
Cu-oxidase_4 pfam02578
Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able ...
 195-303 4.33e-26

Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.


Pssm-ID: 460601 [Multi-domain]  Cd Length: 232  Bit Score: 103.34  E-value: 4.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463642 195 TTRTGGISYIP--------TlssfnlfssskRRDPKVVVQENLRRLANAAGFNVEKFYRIKTHHSNDIWIM-----GRKE 261
Cdd:pfam02578   1 TTRLGGVSEGPyaslnlglH-----------VGDDPEAVAENRRRLAAALGLPPERLVWLRQVHGTDVRVVteddaGAAR 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1370463642 262 PDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAG 303
Cdd:pfam02578  70 EEDADALVTDEPGVALAVLTADCVPVLLADPVGGVVAAAHAG 111
YfiH COG1496
Copper oxidase (laccase) domain [Inorganic ion transport and metabolism];
187-303 7.23e-22

Copper oxidase (laccase) domain [Inorganic ion transport and metabolism];


Pssm-ID: 441105 [Multi-domain]  Cd Length: 246  Bit Score: 92.16  E-value: 7.23e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463642 187 PDIFIHGFTTRTGGISYIP-------TlssfnlfsssKRRDPKVVVQENLRRLANAAGFNVEKFYRIKTHHSNDIWIMGR 259
Cdd:COG1496     9 PPGVRHGFTTRLGGVSQGPydslnlgL----------HVGDDPEAVAENRRRLAAALGLPPDRLVWLNQVHGTRVVVVDA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1370463642 260 KEPDSY----DGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAG 303
Cdd:COG1496    79 PDPDGAipeaDALVTNEPGVALAVLTADCVPVLFADPEGGVVAAAHAG 126
YfiH cd16833
protein of unknown function YfiH; This subfamily contains YfiH, a protein of unknown function ...
 250-303 3.57e-14

protein of unknown function YfiH; This subfamily contains YfiH, a protein of unknown function from Shigella flexneri, E. coli, and many similar proteins which collectively are often called DUF152. The structure of YfiH reveals a distant homology to Rho-activating toxins cytotoxic necrotizing factor 1 (CNF1) as well as chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs), all having an invariant Cys-His pair forming a catalytic dyad, and is required by the CNF-1 toxins for deamidation activity.


Pssm-ID: 319354  Cd Length: 185  Bit Score: 69.54  E-value: 3.57e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370463642 250 HSNDI----WIMGRKEPDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAG 303
Cdd:cd16833     9 HGVRVvdvdDAGGGTAIPEADALITNEPGVALAVLTADCVPVLLYDPKGGVIAAAHAG 66
TIGR00726 TIGR00726
YfiH family protein; PSI-BLAST converges on members of this family of uncharacterized ...
 220-303 7.94e-10

YfiH family protein; PSI-BLAST converges on members of this family of uncharacterized bacterial proteins and shows no significant similarity to any characterized protein. No completed genome to date has two members. Members of the family have been crystallized but the function is unknown. [Unknown function, General]


Pssm-ID: 273235 [Multi-domain]  Cd Length: 221  Bit Score: 57.78  E-value: 7.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463642 220 DPKVVVQENLRRLANAAGFnVEKFYRIKTHHSNDIwimgRKEPDSY------DGITTNQRGVTIAALGADCIPIVFADPV 293
Cdd:TIGR00726  18 DNKAFVLANRERLIAYFNL-PNKIVWLKQVHGDRV----LKVTDKDstlpeaDGLITNTPNLVLAVYTADCVPVLFYDRV 92

                          90
                  ....*....|
gi 1370463642 294 KKACGVAHAG 303
Cdd:TIGR00726  93 GKIVAAVHAG 102
PRK10723 PRK10723
polyphenol oxidase;
195-303 2.39e-04

polyphenol oxidase;


Pssm-ID: 182677  Cd Length: 243  Bit Score: 41.93  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370463642 195 TTRTGGISYIPTLSSFNLFSSSkrrDPKVVVQENLRRLANAAGFNVEKFYRIKTHHSNDIWIMGrKEPDSY--DGITTNQ 272
Cdd:PRK10723   20 STRIGGVSLPPYDSLNLGAHCG---DNPDHVEENRKRLFAAANLPSKPVWLEQVHGTDVLRLTG-EPYASKraDASYSNT 95

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1370463642 273 RGVTIAALGADCIPIVFADPVKKACGVAHAG 303
Cdd:PRK10723   96 PGTVCAVMTADCLPVLFCNRAGTEVAAAHAG 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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