doublecortin domain-containing protein 1 isoform X6 [Homo sapiens]
DCX_DCDC1 and DCX2_DCDC5 domain-containing protein( domain architecture ID 13019604)
DCX_DCDC1 and DCX2_DCDC5 domain-containing protein
List of domain hits
Name | Accession | Description | Interval | E-value | |||
DCX_DCDC1 | cd17155 | Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ... |
174-245 | 2.83e-44 | |||
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis. : Pssm-ID: 340675 Cd Length: 72 Bit Score: 150.62 E-value: 2.83e-44
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DCX2_DCDC5 | cd17157 | Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ... |
295-380 | 1.56e-42 | |||
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8. : Pssm-ID: 340677 Cd Length: 86 Bit Score: 146.34 E-value: 1.56e-42
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Name | Accession | Description | Interval | E-value | |||
DCX_DCDC1 | cd17155 | Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ... |
174-245 | 2.83e-44 | |||
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis. Pssm-ID: 340675 Cd Length: 72 Bit Score: 150.62 E-value: 2.83e-44
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DCX2_DCDC5 | cd17157 | Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ... |
295-380 | 1.56e-42 | |||
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8. Pssm-ID: 340677 Cd Length: 86 Bit Score: 146.34 E-value: 1.56e-42
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DCX | smart00537 | Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ... |
170-252 | 7.76e-04 | |||
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects. Pssm-ID: 214711 Cd Length: 89 Bit Score: 38.78 E-value: 7.76e-04
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Name | Accession | Description | Interval | E-value | |||
DCX_DCDC1 | cd17155 | Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ... |
174-245 | 2.83e-44 | |||
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis. Pssm-ID: 340675 Cd Length: 72 Bit Score: 150.62 E-value: 2.83e-44
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DCX2_DCDC5 | cd17157 | Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ... |
295-380 | 1.56e-42 | |||
Doublecortin-like domain 2 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8. Pssm-ID: 340677 Cd Length: 86 Bit Score: 146.34 E-value: 1.56e-42
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DCX_DCDC5_like | cd17072 | Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ... |
174-240 | 2.05e-21 | |||
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis. Pssm-ID: 340592 Cd Length: 71 Bit Score: 88.10 E-value: 2.05e-21
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DCX_DCDC5_like | cd17072 | Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ... |
295-375 | 2.47e-16 | |||
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis. Pssm-ID: 340592 Cd Length: 71 Bit Score: 73.46 E-value: 2.47e-16
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DCX1_DCDC5 | cd17156 | Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ... |
174-246 | 6.15e-12 | |||
Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8. Pssm-ID: 340676 Cd Length: 76 Bit Score: 61.15 E-value: 6.15e-12
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DCX3_DCDC5 | cd17158 | Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ... |
174-244 | 2.67e-11 | |||
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8. Pssm-ID: 340678 Cd Length: 73 Bit Score: 59.25 E-value: 2.67e-11
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DCX4_DCDC5 | cd17159 | Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ... |
175-245 | 1.39e-07 | |||
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8. Pssm-ID: 340679 Cd Length: 73 Bit Score: 48.83 E-value: 1.39e-07
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DCX3_DCDC5 | cd17158 | Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ... |
295-380 | 1.90e-07 | |||
Doublecortin-like domain 3 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8. Pssm-ID: 340678 Cd Length: 73 Bit Score: 48.46 E-value: 1.90e-07
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DCX4_DCDC5 | cd17159 | Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ... |
296-379 | 1.99e-07 | |||
Doublecortin-like domain 4 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8. Pssm-ID: 340679 Cd Length: 73 Bit Score: 48.45 E-value: 1.99e-07
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DCX | smart00537 | Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ... |
170-252 | 7.76e-04 | |||
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects. Pssm-ID: 214711 Cd Length: 89 Bit Score: 38.78 E-value: 7.76e-04
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DCX | cd01617 | Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ... |
174-238 | 1.54e-03 | |||
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation. Pssm-ID: 340456 Cd Length: 73 Bit Score: 37.21 E-value: 1.54e-03
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DCX_DCDC1 | cd17155 | Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); ... |
295-336 | 6.48e-03 | |||
Doublecortin-like domain found in doublecortin domain-containing protein 1 (DCDC1); Doublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCX gene family consists of eleven paralogs in human and mouse, such that its protein domains can occur in tandem or single repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction while single DCX repeat proteins are normally localized to actin-rich subcellular structures or to the nucleus. DCDC1 is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis. Pssm-ID: 340675 Cd Length: 72 Bit Score: 35.44 E-value: 6.48e-03
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Blast search parameters | ||||
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