|
Name |
Accession |
Description |
Interval |
E-value |
| PRK13572 |
PRK13572 |
anthranilate synthase component I; Provisional |
1-433 |
0e+00 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 237432 [Multi-domain] Cd Length: 435 Bit Score: 792.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 1 MPLKKLKPVDPLKLYSALRDFGMPFMLRSAEKDSRKARFTYISAEPEFVVEVGEGTEIDGERVSDERNPLRALKGLMGER 80
Cdd:PRK13572 1 MLMKKLDYVNPLKLYSVLRDEGYPFILESAEKGQRKARYTYISANPEFMVRIGNKTKVDGETISKESNPFKALKENFKIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 81 VEGRRFMGGFVGYVSYDSVHSIIGGKIEEPSVFGYYPWTFIYDHSTGALSFFYLREAP---FDPEALVERARREESRLED 157
Cdd:PRK13572 81 QSGDRFTGGFVGYIAYDAVHNYIGGKIEEPSVFGYYDHVFVYDHVTRKFYFHSLNNNPeelFNAEKIVEKAKRFEIEEED 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 158 GGSEVISTDAGMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLDALEIYKRLVELNPSPYTFILEFEKTVVGASPET 237
Cdd:PRK13572 161 GGSEVLGCDADREEFVEMVEKAKEYIYSGDVFQVVLSREYRLKTDLSPFQLYRNLREINPSPYMFLLEFDKDVVGASPET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 238 MGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQH 317
Cdd:PRK13572 241 MASVENNILKINPIAGTAPRGKTEEEDKKLAEALLSDEKERAEHVMLVDLARNDVRKVSKSGSVRLERFFDVVKYSHVQH 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 318 IESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEgRKA 397
Cdd:PRK13572 321 IESEVVGELKEDSTMFDAIEAAFPAGTLTGAPKFRAMEIIDELEKSRRKVYGGAVGYFSNSGNADLAIAIRMAEID-KVC 399
|
410 420 430
....*....|....*....|....*....|....*.
gi 1365616763 398 SVRAGAGIVADSVPEKEFFETENKMRAVLKALGVRE 433
Cdd:PRK13572 400 RVRAGAGIVADSVPEKEFYETERKMAAVLKALGVVN 435
|
|
| TrpE-arch |
TIGR01820 |
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of ... |
11-430 |
0e+00 |
|
anthranilate synthase component I, archaeal clade; This model represents an archaeal clade of anthranilate synthase component I enzymes. This enzyme is responsible for the first step of tryptophan biosynthesis from chorismate. The Sulfolobus enzyme has been reported to be part of a gene cluster for Trp biosynthesis [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273819 [Multi-domain] Cd Length: 435 Bit Score: 590.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 11 PLKLYSALR-DFGMPFMLRSAEKDSRKARFTYISAEPEFVVEVGEGT------EIDGERVSDERNPLRALKGLmGERVEG 83
Cdd:TIGR01820 1 PLELYKAIRaDGDYAFLLESAEKPSKKARYSFIGWDPEFVVRINGKGksvegiPEDGDVVDKLRNAFPKLKGI-NIPGED 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 84 RRFMGGFVGYVSYDSVHSIIGGKIEE--------PSVFGYYPWTFIYDHSTGALSFFYLREAPFDPEALVERARREESRL 155
Cdd:TIGR01820 80 RRFKGGLVGYIAYDAVRDYWEGIVDLkrkaedwpPAEFFIYPNTIVYDHLEGKVYYVSTPEPEAELERIVERAKRATDPG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 156 EDGGSEVISTDAGMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLDALEIYKRLVELNPSPYTFILEF-EKTVVGAS 234
Cdd:TIGR01820 160 EAGVSFEGESLSDREEFEEAVEEAKEYIFAGDIFQVVLSREYEYRLDGDPFELYYNLREINPSPYMFLLKFgDRYLVGSS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 235 PETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSH 314
Cdd:TIGR01820 240 PETLVRVEGRTVETNPIAGTRPRGATPEEDERLAKELLSDEKERAEHVMLVDLARNDVRKVSEPGSVKVPEFMYVEKYSH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 315 VQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEG 394
Cdd:TIGR01820 320 VQHIESTVIGTLKKDYDAFDALRATFPAGTLSGAPKIRAMEIIDELEKEPRGVYGGGVGYFSWNGDADFAIAIRTAEIDK 399
|
410 420 430
....*....|....*....|....*....|....*.
gi 1365616763 395 RKASVRAGAGIVADSVPEKEFFETENKMRAVLKALG 430
Cdd:TIGR01820 400 DKLRIQAGAGIVADSIPEREFEETENKMKAVLKAIG 435
|
|
| TrpE |
COG0147 |
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, ... |
9-431 |
0e+00 |
|
Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Anthranilate/para-aminobenzoate synthases component I is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis
Pssm-ID: 439917 [Multi-domain] Cd Length: 416 Bit Score: 514.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 9 VDPLKLYSALRDFGMPFMLRSAEKDSRKARFTYISAEPEFVVEVGEGT---EIDGERVSDERNPLRALKGLMGE-RVEGR 84
Cdd:COG0147 13 ETPVSLFLKLADGPYAFLLESAEGGEKWGRYSFIGADPLATLTVRGGRvtiEGGGEVEPSEGDPLDALRALLARfRLPPL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 85 ----RFMGGFVGYVSYDSVHSIIGGKIEEPS-------VFGYYPWTFIYDHstgalsffylreapfdpealverARREES 153
Cdd:COG0147 93 pglpPFTGGLVGYFGYDLVRYFERLPDLAPDdlglpdaALGLYDRLLVFDH-----------------------LKGTRS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 154 RLEDggsevistdagmEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLDALEIYKRLVELNPSPYTFILEF-EKTVVG 232
Cdd:COG0147 150 NFTR------------EEYLAAVERAKEYIRAGDIFQVVLSQRFSAPFEGDPLALYRALRRINPSPYMFYLRFgDFAIVG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 233 ASPETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKY 312
Cdd:COG0147 218 SSPERLVRVEDGRVETRPIAGTRPRGATPEEDAALAEELLADEKERAEHLMLVDLARNDLGRVCEPGSVKVPELMVVERY 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 313 SHVQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEI 392
Cdd:COG0147 298 SHVMHLVSTVTGRLRPGLDALDALRATFPAGTLTGAPKIRAMEIIDELEPTRRGVYGGAVGYLSFDGNMDLAIAIRTAVV 377
|
410 420 430
....*....|....*....|....*....|....*....
gi 1365616763 393 EGRKASVRAGAGIVADSVPEKEFFETENKMRAVLKALGV 431
Cdd:COG0147 378 KDGRAYVQAGAGIVADSDPEAEYQETLNKARALLRALEL 416
|
|
| trpE_most |
TIGR00564 |
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some ... |
9-430 |
5.74e-142 |
|
anthranilate synthase component I, non-proteobacterial lineages; This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. Archaeal enzymes have been excluded from this model (and are now found in TIGR01820) as have a clade of enzymes which constitute a TrpE paralog which may have PabB activity (TIGR01824). This allows the B. subtilus paralog which has been shown to have PabB activity to score below trusted to this model. This model contains sequences from gram-positive bacteria, certain proteobacteria, cyanobacteria, plants, fungi and assorted other bacteria.A second family of TrpE enzymes is modelled by TIGR00565. The breaking of the TrpE family into these diverse models allows for the separation of the models for the related enzyme, PabB. [Amino acid biosynthesis, Aromatic amino acid family]
Pssm-ID: 273142 [Multi-domain] Cd Length: 454 Bit Score: 413.27 E-value: 5.74e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 9 VDPLKLYSALRDFGMP--FMLRSAEKDSRKARFTYISAEPEFVVEVGEGTEI---DGERVSDERNPLRALKGLMGERVEG 83
Cdd:TIGR00564 1 ADTLTPISAYLKLAQPgsFLLESAEPGSERGRYSFIGLNPVLTIKTEGGTEYlgaDDRRSGIVGNPLDEIRDVMETFAQH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 84 RR------FMGGFVGYVSYDSVHSIIGGKIEEPSV-------FGYYPWTFIYDHSTGALSFFYLREAPFDPEALVERARR 150
Cdd:TIGR00564 81 SDpelpipFTGGAVGYLGYDTVRLFEKITLPPPDPlnlpdayLMLCDDFIIFDHVTDKLYLIHNNRTTASRSAKAAADAR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 151 EESRLEDG-------------GSEVISTDAGMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLDALEIYKRLVELNP 217
Cdd:TIGR00564 161 LEALVADLqdpllpevpvpypAALSFTSNYEKEEYEANVAKAKEYIKAGDIFQVVLSQRFEAKTEAPPFELYRVLRIVNP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 218 SPYTFILEFEKT-VVGASPETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVS 296
Cdd:TIGR00564 241 SPYMYYLDFGDFqIVGSSPELLVKVTGGRITTRPIAGTRKRGATPEEDEALAEELLADEKERAEHLMLVDLGRNDIGRVC 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 297 KPGSVRLTRFFDVLKYSHVQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFS 376
Cdd:TIGR00564 321 EPGSVEVPEFMKIERYSHVMHIVSTVEGRLKDGLTAIDALRATFPAGTVSGAPKIRAMELIDELEPEKRGIYGGAVGYLS 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 1365616763 377 LTGDADMAIAIRMAEIEGRKASVRAGAGIVADSVPEKEFFETENKMRAVLKALG 430
Cdd:TIGR00564 401 FDGDMDTAIAIRTMVVKDGKAYVQAGGGIVADSDPEAEYEETLNKARALLRAIE 454
|
|
| PRK13571 |
PRK13571 |
anthranilate synthase component I; Provisional |
11-433 |
1.65e-118 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184152 [Multi-domain] Cd Length: 506 Bit Score: 355.10 E-value: 1.65e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 11 PLKLYSALRDfGMP--FMLRSAEKDSRKARFTYISAEPEFVVevgegTEIDGERV---------SDERNPLRALKG---- 75
Cdd:PRK13571 36 PVGAYRKLAA-NRPgtFLLESAENGRSWSRWSFIGVGSPAAL-----TVRDGEAVwlgtppagaPTGGDPLAALRAtlel 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 76 LMGERVEGRR-FMGGFVGYVSYDSVHSIigGKIEEPSV--FGYYPWTFIY-------DHSTGALSffyLREAPFDPEALV 145
Cdd:PRK13571 110 LATPRLPGLPpLTGGMVGFLGYDAVRRL--ERLPELAVddLGLPEMLLLLatdlaavDHHEGTIT---LIANAVNWNGTD 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 146 ERA--------RREESRLEDGGSEVISTDA-------------GMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLD 204
Cdd:PRK13571 185 ERVdaayddavARLDVMTAALAQPLPSTVAtfsrpvpefraqrTVEEFGAAVEKLVEEIRAGEAFQVVPSQRFEMDTTAD 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 205 ALEIYKRLVELNPSPYTFILEFEK-------TVVGASPETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKE 277
Cdd:PRK13571 265 PLDVYRVLRVTNPSPYMYLLRVPNsdggtdfSIVGSSPEALVTVTDGRATTHPIAGTRWRGATPEEDALLEKELLADPKE 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 278 RAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEII 357
Cdd:PRK13571 345 RAEHLMLVDLGRNDLGRVCRPGTVRVVDFSHIERYSHVMHLVSTVTGELAEGRTALDAVTACFPAGTLSGAPKVRAMELI 424
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1365616763 358 DELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKASVRAGAGIVADSVPEKEFFETENKMRAVLKALGVRE 433
Cdd:PRK13571 425 EELEPTRRGLYGGVVGYLDFAGDADTAIAIRTALMRDGTAYVQAGGGVVADSDPDYEDNEARNKAAAVLRAIAAAE 500
|
|
| Chorismate_bind |
pfam00425 |
chorismate binding enzyme; This family includes the catalytic regions of the chorismate ... |
170-421 |
3.59e-118 |
|
chorismate binding enzyme; This family includes the catalytic regions of the chorismate binding enzymes anthranilate synthase, isochorismate synthase, aminodeoxychorismate synthase and para-aminobenzoate synthase.
Pssm-ID: 425674 [Multi-domain] Cd Length: 255 Bit Score: 344.92 E-value: 3.59e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 170 EEFVEIVRAGKEYIYSGDVFQVVLSREYRVR--TDLDALEIYKRLVELNPSPYTFILEFE-KTVVGASPETMGSVEGRTF 246
Cdd:pfam00425 1 EDYLAAVEKAKEAIRAGDLYKVVLSRRLTLPlaGDIDPLALYRRLRARNPAPYSFYFRTGdFTFLGASPERLLSVDGGRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 247 KINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQHIESEVVGEL 326
Cdd:pfam00425 81 ITEPIAGTRPRGKDPAEDEALAAELLADPKERAEHLMVVDLIRNDLGRVCVPGSVKVPELPEVERYGTVQHLVSTISGRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 327 DEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKASVRAGAGIV 406
Cdd:pfam00425 161 KPGLSLLDLLKALFPTGAVTGAPKKRAMEIIRELEPFPRGLYAGAVGYLDPDGDADFAVAIRTALVDNGRARLYAGAGIV 240
|
250
....*....|....*
gi 1365616763 407 ADSVPEKEFFETENK 421
Cdd:pfam00425 241 ADSDPEAEWEETEAK 255
|
|
| PRK13574 |
PRK13574 |
anthranilate synthase component I; Provisional |
10-431 |
2.06e-101 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184155 [Multi-domain] Cd Length: 420 Bit Score: 308.28 E-value: 2.06e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 10 DPLKLYSAL-RDFGMPFMLRSAEKDSRKARFTYIsaepefVVEVGEGTEIDGERVSDERNPLRALKGLMgervEGRRFMG 88
Cdd:PRK13574 11 SPFEVFKCIeRDFKVAGLLESIGGPQYKARYSVI------AWGTNGYLKIHDDPVNILNSYLKDLKLVD----IPGLFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 89 GFVGYVSYDSV---HSIIGGK--IEE-PSVFGYYPWTFI-YDHSTGALsffYLREApfDPEAlverarreESRLEDGGSE 161
Cdd:PRK13574 81 GMIGYISYDAVrfwEKIRDLKpaAEDwPYAEFFIPDNIIiYDHNEGKV---YVNGD--LSSV--------GGCGDMGEFK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 162 VISTDAGM--EEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLDALEIYKRLVELNPSPYTFILEF-EKTVVGASPETM 238
Cdd:PRK13574 148 ISFYDESLnkNNYEKIVSESLEYIRSGYIFQVVLSRFYRYLFSGDPLRIYYNLRRINPSPYMFYLKFdERYLIGSSPELL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 239 GSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQHI 318
Cdd:PRK13574 228 FRVQDNIVETYPIAGTRPRGSDQEEDLKLELELMNSEKDKAEHLMLVDLARNDLGKVCVPGTVRVPELMYVEKYSHVQHI 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 319 ESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKAS 398
Cdd:PRK13574 308 VSKVIGTLKKKYNALDVLKATFPAGTVSGAPKPMAMNIIETLEEYKRGPYAGAVGFISADGNAEFAIAIRTAFLNKDLLR 387
|
410 420 430
....*....|....*....|....*....|...
gi 1365616763 399 VRAGAGIVADSVPEKEFFETENKMRAVLKALGV 431
Cdd:PRK13574 388 IQAGAGIVYDSNPESEYFETEHKLRALKTAIGV 420
|
|
| PLN02445 |
PLN02445 |
anthranilate synthase component I |
86-433 |
2.89e-97 |
|
anthranilate synthase component I
Pssm-ID: 215244 [Multi-domain] Cd Length: 523 Bit Score: 301.21 E-value: 2.89e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 86 FMGGFVGYVSYDSVHSIIGGKI----------EEPSV-FGYYPWTFIYDHSTGAL---------SFFYLREAPFDP---- 141
Cdd:PLN02445 118 FCGGWVGYFSYDTVRYVEKKKLpfsgapeddrNLPDIhLGLYDDVIVFDHVEKKAyvihwvrldRYSSVEEAYEDGmkrl 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 142 EALVERARREE-SRLEDG---------GSEVISTDAGMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLDALEIYKR 211
Cdd:PLN02445 198 EALVSRLQDINpPKLSPGsvklstnqfGPSLEKSNMTSEEYKNAVLQAKEHILAGDIFQIVLSQRFERRTFADPFEVYRA 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 212 LVELNPSPYTFILEFEKTV-VGASPETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARN 290
Cdd:PLN02445 278 LRIVNPSPYMIYLQARGCIlVASSPEILTRVKKNKIVNRPLAGTRRRGKTPEEDKALEKDLLADEKQCAEHIMLVDLGRN 357
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 291 DVRRVSKPGSVRLTRFFDVLKYSHVQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGG 370
Cdd:PLN02445 358 DVGKVSKAGSVKVEKLMNIERYSHVMHISSTVTGELLDHLTSWDALRAALPVGTVSGAPKVRAMELIDELEVTRRGPYSG 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 371 AVGYFSLTGDADMAIAIR---------------MAEIEGRK---ASVRAGAGIVADSVPEKEFFETENKMRAVLKALGVR 432
Cdd:PLN02445 438 GFGGVSFTGDMDIALALRtmvfptaarydtmysYKDTNSRRewvAHLQAGAGIVADSDPEDEYRECVNKAAGLARAIDLA 517
|
.
gi 1365616763 433 E 433
Cdd:PLN02445 518 E 518
|
|
| PRK09070 |
PRK09070 |
aminodeoxychorismate synthase component I; |
1-431 |
2.51e-94 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236371 [Multi-domain] Cd Length: 447 Bit Score: 291.22 E-value: 2.51e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 1 MPLKKLKPVDP--LKLYSALRDfGMPFMLRSAEKDSRKARFTYISAEPE-FVVEVGEGteidGERVSDERNPLRALKGL- 76
Cdd:PRK09070 1 MTLTRPLPADIdlLALHRLAPE-RYPALLESSASGTAQGRWDVLLLAQGkCLRLDPDG----VTRQLLEGDFLDALDAAw 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 77 MGERVEGRR-----FMGGFVGYVSYDSVHSIiggkieEPSV-------------FGYYPWTFIYDHSTGALSFFylreAP 138
Cdd:PRK09070 76 QAERVPHDGesslpFRGGWAVLLDYELAGQV------EPILklpmrtdglplalALRAPAAVLRDRHSGRCVLV----AE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 139 FDPEALVERARREESRLED-------GGSEVISTDAGmEEFVEIVRAGKEYIYSGDVFQVVLSR--EYRVRTDLDALEIY 209
Cdd:PRK09070 146 PGREHLLDQIEADLAACAAlpplpvwLAPQAVEEDPP-ERFTDGVERVLDYIRAGDVFQVNLSRawQAQFANAVDPAALY 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 210 KRLVELNPSPYTFILEFE-KTVVGASPETMGSVEGRTFKINPIAGTAPRGrTGEEDRELEKALLSDEKERAEHVMLVDLA 288
Cdd:PRK09070 225 ARLRAANPAPFSGLFVAAgRAIVSSSPERLVSVQGGVVQTRPIAGTRPRF-AGDDDAALIRELVGHPKERAEHVMLIDLE 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 289 RNDVRRVSKPGSVRLTRFFDVLKYSHVQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVY 368
Cdd:PRK09070 304 RNDLGRICAPGSVEVDELMTVESYAHVHHIVSNVRGRLRDGVTPGEVIRAVFPGGTITGCPKVRCMQIIAELEQTPRGAY 383
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1365616763 369 GGAVGYFSLTGDADMAIAIRMAEIEGRKASVRAGAGIVADSVPEKEFFETENKMRAVLKALGV 431
Cdd:PRK09070 384 TGSFGYLNRDGDMDLNILIRTAEVQGNQVRFRTGAGIVVDSDPERELDETRAKARGLLRALEQ 446
|
|
| PRK13564 |
PRK13564 |
anthranilate synthase component 1; |
170-428 |
1.07e-93 |
|
anthranilate synthase component 1;
Pssm-ID: 237428 [Multi-domain] Cd Length: 520 Bit Score: 291.74 E-value: 1.07e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 170 EEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDlDALEIYKRLVELNPSPYTFILEFEK-TVVGASPEtmgS-----VEG 243
Cdd:PRK13564 243 EEFCAVVRKLKEHIRAGDIFQVVPSRRFSLPCP-SPLAAYRVLKKSNPSPYMFYMQDEDfTLFGASPE---SalkydASS 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 244 RTFKINPIAGTAPRGRT--GEEDREL----EKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQH 317
Cdd:PRK13564 319 RQVEIYPIAGTRPRGRRadGSIDRDLdsriELELRTDHKELAEHLMLVDLARNDLARICQPGSRYVADLLKVDRYSHVMH 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 318 IESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKA 397
Cdd:PRK13564 399 LVSRVVGELRHDLDALHAYRACMNMGTLTGAPKVRAMQLIREVEGQRRGSYGGAVGYLTGHGDLDTCIVIRSAFVENGIA 478
|
250 260 270
....*....|....*....|....*....|.
gi 1365616763 398 SVRAGAGIVADSVPEKEFFETENKMRAVLKA 428
Cdd:PRK13564 479 TVQAGAGVVLDSDPQSEADETRNKAQAVLRA 509
|
|
| PRK05940 |
PRK05940 |
anthranilate synthase component I; |
86-430 |
4.41e-92 |
|
anthranilate synthase component I;
Pssm-ID: 235651 [Multi-domain] Cd Length: 463 Bit Score: 285.85 E-value: 4.41e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 86 FMGGFVGYVSYDsvhsiIGGKIEE-----------PSVFGYYPWTF-IYDHSTGALsffYLreAPFDPEAL------VER 147
Cdd:PRK05940 96 FTGGWLGWLGYD-----LAWEIERlphlnpdplpfPVAYWYEPESFaILDHQEQIL---WL--AASDPSQLdrleqqLEQ 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 148 ARREESRLEDGGSEVISTDAGM--EEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLDALEIYKRLVELNPSPYTfilE 225
Cdd:PRK05940 166 PTPEPDLPLDLRTPPSSLIFYTtqQEYEAAVRQAKKYIQAGDIFQANLSLRFQTTTSADSWQIYRRLQQINPSPFA---S 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 226 FEKT----VVGASPETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSV 301
Cdd:PRK05940 243 YWRTpwgdVVSCSPERLVQLQGNQAQTRPIAGTRPRGKTPAEDQQLAEELLSNIKERAEHIMLVDLERNDLGRVCQWGSV 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 302 RLTRFFDVLKYSHVQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDA 381
Cdd:PRK05940 323 EVDELLTIERYSHVIHLVSNVVGTLQPNRDAIDLIRALFPGGTITGCPKVRCMEIIEELEPVRRNLFYGSCGYLDQRGNL 402
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1365616763 382 DMAIAIR---MAEIEGRKASV--RAGAGIVADSVPEKEFFETENKMRAVLKALG 430
Cdd:PRK05940 403 DLNILIRtllYTPLSRGLSTIwgQVGAGIVADSDPEKEWLESLQKAKAQLAALN 456
|
|
| PabB-clade2 |
TIGR01824 |
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely ... |
88-425 |
8.83e-90 |
|
aminodeoxychorismate synthase, component I, clade 2; This clade of sequences is more closely related to TrpE (anthranilate synthase, TIGR00564/TIGR01820/TIGR00565) than to the better characterized group of PabB enzymes (TIGR00553/TIGR01823). This clade includes one characterized enzyme from Lactococcus and the conserved function across the clade is supported by these pieces of evidence: 1) all genomes with a member in this clade also have a separate TrpE gene, 2) none of these genomes contain an aparrent PabB from any of the other PabB clades, 3) none of these sequences are found in a region of the genome in association with other Trp biosynthesis genes, 4) all of these genomes aparrently contain most if not all of the steps of the folate biosynthetic pathway (for which PABA is a precursor). Many of the sequences hit by this model are annotated as TrpE enzymes, however, we believe that all members of this clade are, in fact, PabB. The sequences from Bacillus halodurans and subtilus which score below the trusted cutoff for this model are also likely to be PabB enzymes, but are too closely related to TrpE to be separated at this time.
Pssm-ID: 130883 Cd Length: 355 Bit Score: 276.27 E-value: 8.83e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 88 GGFVGYVSYD---SVHSIIGGKIEE---PSVFGY-YPWTFIYDHSTGALsffYLREAPFDPEALVERARREES------R 154
Cdd:TIGR01824 1 GGRLGWLAYDvarRLEGIPDLGTSDggwPVAADFrYEAAVARDHQRQIV---ALATVPAETEGEFATSSDQLPavaaatS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 155 LEDGGSEVISTD----AGMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRT--DLDALEIYKRLVELNPSPYTFILEFEK 228
Cdd:TIGR01824 78 LPSPDVGPLPVDleasIDRAAYETGVRRIKDYIRAGDVFQANLSRRLTAPIaaDVDPLQLFLALRAPNPAPYAIYLEEPG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 229 T-VVGASPETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFF 307
Cdd:TIGR01824 158 VdVASASPELFLAREGRVVQTRPIAGTRPRGATLAEDGALAAELLQHDKDRAEHVMIVDLERNDLGRVCATGTVRVPELC 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 308 DVLKYSHVQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAI 387
Cdd:TIGR01824 238 AVESYSHVHHLVSRVTGRLREGAGLADLIRALFPGGSITGAPKVRAMEIIDELEPQPRGPYTGSVGWIDADGNADLNILI 317
|
330 340 350
....*....|....*....|....*....|....*...
gi 1365616763 388 RMAEIEGRKASVRAGAGIVADSVPEKEFFETENKMRAV 425
Cdd:TIGR01824 318 RTLEGGGAQLHFRTGAGIVADSDPAGEWDETEAKARAL 355
|
|
| pabB |
TIGR00553 |
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, ... |
91-423 |
7.24e-82 |
|
aminodeoxychorismate synthase, component I, bacterial clade; Members of this family, aminodeoxychorismate synthase, component I (PabB), were designated para-aminobenzoate synthase component I until it was recognized that PabC, a lyase, completes the pathway of PABA synthesis. This family is closely related to anthranilate synthase component I (trpE), and both act on chorismate. The clade of PabB enzymes represented by this model includes sequences from Gram-positive and alpha and gamma Proteobacteria as well as Chlorobium, Nostoc, Fusobacterium and Arabidopsis. A closely related clade of fungal PabB enzymes is identified by TIGR01823, while another bacterial clade of potential PabB enzymes is more closely related to TrpE (TIGR01824). [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 273133 Cd Length: 328 Bit Score: 255.00 E-value: 7.24e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 91 VGYVSYDSvhsiiggkiEEPSVFGYYPWTFIYDHSTGALSFFYLREapfDPEALVERARREESRLEDGGSEVIS---TDA 167
Cdd:TIGR00553 2 VGYLSYEA---------GPDAAFEPYDAALLADHRRTPLLRFLVFE---RVEAQPRAAVEAEDDAPADRQAPTSdiqSEM 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 168 GMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLDALEIYKRLVELNPSPYTFILEF-EKTVVGASPETMGSVEGRTF 246
Cdd:TIGR00553 70 TRAEYGEAIDQLQDYIRAGDCYQANLTQQFHATWDGDPLAAFRKLRRRQPAPFSAFLDLgDGAILSLSPELFFSIDGSEI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 247 KINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQHIESEVVGEL 326
Cdd:TIGR00553 150 ETRPIKGTLPRGADPQEDRAQASALAESAKDRAENLMIVDLLRNDLGRIAEVGSVKVPELFVVETYPTVHQLVSTITARL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 327 DEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKASVRAGAGIV 406
Cdd:TIGR00553 230 REDLTLSDLFRALFPGGSITGAPKVRAMEIIDELEPQPRGVYCGAIGYLSPEGDMDFNVAIRTLTLDGGRAVYGVGGGIV 309
|
330
....*....|....*..
gi 1365616763 407 ADSVPEKEFFETENKMR 423
Cdd:TIGR00553 310 ADSDPEAEYRECLLKAA 326
|
|
| PRK13567 |
PRK13567 |
anthranilate synthase component I; Provisional |
162-427 |
1.73e-74 |
|
anthranilate synthase component I; Provisional
Pssm-ID: 184148 [Multi-domain] Cd Length: 468 Bit Score: 240.43 E-value: 1.73e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 162 VISTDAGMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVR----TDLDAL--EIYKRLVELNPSPYTFILEF-EKTVVGAS 234
Cdd:PRK13567 193 EIQSNISEERFIEMIQYFKEKITEGDMFQVVPSRIYKYAhhasQHLNQLsfQLYQNLKRQNPSPYMYYLNIdQPYIVGSS 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 235 PETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSH 314
Cdd:PRK13567 273 PESFVSVKDQIVTTNPIAGTIQRGETTQIDNENMKQLLNDPKECSEHRMLVDLGRNDIHRVSKIGTSKITKLMVIEKYEH 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 315 VQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEG 394
Cdd:PRK13567 353 VMHIVSEVTGKINQNLSPMTVIANLLPTGTVSGAPKLRAIERIYEQYPHKRGVYSGGVGYINCNHNLDFALAIRTMMIDE 432
|
250 260 270
....*....|....*....|....*....|...
gi 1365616763 395 RKASVRAGAGIVADSVPEKEFFETENKMRAVLK 427
Cdd:PRK13567 433 QYINVEAGCGVVYDSIPEKELNETKLKAKSLLE 465
|
|
| MenF |
COG1169 |
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites ... |
127-431 |
2.38e-72 |
|
Isochorismate synthase EntC [Coenzyme transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]; Isochorismate synthase EntC is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 440783 [Multi-domain] Cd Length: 353 Bit Score: 231.19 E-value: 2.38e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 127 GALSFFYLREAP----FDPEALVERARREEsrledggsevisTDAgmEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTD 202
Cdd:COG1169 56 GGFAFDPDSPAPaarlVLPRLLLRRSRRGV------------PDP--AEWREAVAQALEAIRAGELDKVVLARALDLTLD 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 203 --LDALEIYKRLVELNPSPYTFILEFEK--TVVGASPETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKER 278
Cdd:COG1169 122 epIDPRALLARLRRRNPDCYTFAVELGAgdGFVGASPERLVRRRGGQLTTEALAGTAPRGADPEEDAALAAALLASEKDR 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 279 AEHvmlvDLARNDVRRVSKPGSVRLTRFFD--VLKYSHVQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEI 356
Cdd:COG1169 202 REH----ALVVDSIREALAPLCSSLDVPEEpeLLRLRNVQHLATPITGTLDPGVSALDLAAALHPTPAVGGTPREAALAL 277
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1365616763 357 IDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKASVRAGAGIVADSVPEKEFFETENKMRAVLKALGV 431
Cdd:COG1169 278 IRELEPFDRGWYAGPVGWVDADGDGEFAVAIRSALIDGNRARLFAGAGIVAGSDPEAEWAETEAKLRTMLRALGL 352
|
|
| pabB |
PRK15465 |
aminodeoxychorismate synthase component 1; |
26-429 |
7.13e-66 |
|
aminodeoxychorismate synthase component 1;
Pssm-ID: 185362 [Multi-domain] Cd Length: 453 Bit Score: 217.48 E-value: 7.13e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 26 MLRSAEKDSRKARFTYISAEPEFVVEV-GEGTEI-DGE-RVSDERNPLRALK------GLMGERVEGRRFMGGFVGYVSY 96
Cdd:PRK15465 33 LLHSGYADHPYSRFDIVVADPICTLTTfGKETVVsESEkRTTTTDDPLQVLQqvldraDIRPTHNEDLPFQGGALGLFGY 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 97 D------SVHSIIGGKIEEPSV-FGYYPWTFIYDHSTGALSFFylreAPFDPEALVE--RARREESRLEDGGSEVISTDA 167
Cdd:PRK15465 113 DlgrrfeSLPEIAEQDIVLPDMaVGIYDWALIVDHQRQTVSLL----SHNDVNARRAwlESQQFSPQEDFTLTSDWQSNM 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 168 GMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLDALEIYKRLVELNPSPYTFILEFEK-TVVGASPETMGSVEGRTF 246
Cdd:PRK15465 189 TREQYGEKFRQVQEYLHSGDCYQVNLAQRFHATYSGDEWQAFLQLNQANRAPFSAFLRLEQgAILSLSPERFILCDNSEI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 247 KINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQHIESEVVGEL 326
Cdd:PRK15465 269 QTRPIKGTLPRLPDPQEDSKQAEKLANSAKDRAENLMIVDLMRNDIGRVAVAGSVKVPELFVVEPFPAVHHLVSTITARL 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 327 DEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKASVRAGAGIV 406
Cdd:PRK15465 349 PEQLHASDLLRAAFPGGSITGAPKVRAMEIIDELEPQRRNAWCGSIGYLSFCGNMDTSITIRTLTAINGQIYCSAGGGIV 428
|
410 420
....*....|....*....|...
gi 1365616763 407 ADSVPEKEFFETENKMRAVLKAL 429
Cdd:PRK15465 429 ADSQEEAEYQETFDKVNRILRQL 451
|
|
| PRK13566 |
PRK13566 |
anthranilate synthase component I; |
171-433 |
1.84e-58 |
|
anthranilate synthase component I;
Pssm-ID: 237429 [Multi-domain] Cd Length: 720 Bit Score: 203.61 E-value: 1.84e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 171 EFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLDALEIYKRLVELNPSPYTFILEF--EKTVVGASPETMGSVEGRTFKI 248
Cdd:PRK13566 245 EYAALVEKAKESFRRGDLFEVVPGQTFYEPCERSPSEIFRRLKEINPSPYGFFINLgdGEYLVGASPEMFVRVEGRRVET 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 249 NPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSH----VQHIEsevvG 324
Cdd:PRK13566 325 CPISGTIKRGADAIGDAEQIRKLLNSKKDESELTMCTDVDRNDKSRVCEPGSVKVIGRRQIEMYSRlihtVDHVE----G 400
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 325 ELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKASVRAGAG 404
Cdd:PRK13566 401 RLRPGFDALDAFLTHAWAVTVTGAPKLWAMQFIEDHERSPRRWYGGAVGMVGFDGDMNTGLTLRTIRIKDGVAEVRVGAT 480
|
250 260
....*....|....*....|....*....
gi 1365616763 405 IVADSVPEKEFFETENKMRAVLKALGVRE 433
Cdd:PRK13566 481 LLFDSDPEAEEAETELKASALLQALRGAK 509
|
|
| PLN02889 |
PLN02889 |
oxo-acid-lyase/anthranilate synthase |
166-429 |
2.24e-56 |
|
oxo-acid-lyase/anthranilate synthase
Pssm-ID: 215481 [Multi-domain] Cd Length: 918 Bit Score: 200.07 E-value: 2.24e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 166 DAGMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRT-DLDALEIYKRLVELNPSPYTFILEFEK---TVVGASPETMGSV 241
Cdd:PLN02889 640 DKSREQYIKDVQKCLKYIKDGESYELCLTTQMRKRIgEIDSLGLYLHLREKNPAPYAAWLNFSNenlCICSSSPERFLKL 719
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 242 EGR-TFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQHIES 320
Cdd:PLN02889 720 DRNgMLEAKPIKGTIARGSTPEEDEQLKLQLQYSEKDQAENLMIVDLLRNDLGRVCEPGSVHVPNLMDVESYTTVHTMVS 799
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 321 EVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKASVR 400
Cdd:PLN02889 800 TIRGKKRSNMSPVDCVRAAFPGGSMTGAPKLRSMELLDSLESSSRGIYSGSIGFFSYNQTFDLNIVIRTVVIHEGEASIG 879
|
250 260
....*....|....*....|....*....
gi 1365616763 401 AGAGIVADSVPEKEFFETENKMRAVLKAL 429
Cdd:PLN02889 880 AGGAIVALSNPEDEYEEMILKTRAPANAV 908
|
|
| PRK07508 |
PRK07508 |
aminodeoxychorismate synthase component I; |
180-428 |
9.45e-55 |
|
aminodeoxychorismate synthase component I;
Pssm-ID: 236035 [Multi-domain] Cd Length: 378 Bit Score: 186.37 E-value: 9.45e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 180 KEYIYSGDVFQVVLSREYRVRTDLDALEIYKRLVELNPSPY-TFILEFEKTVVGASPETMGSVEG-RTFKINPIAGTAPR 257
Cdd:PRK07508 122 HRHIRAGDCYQANLTFPLDARWGGDPLALFWALAARQPVGYgALVDLGGPVILSRSPELFFRVDGeGWIETHPMKGTAPR 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 258 GRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQHIESEVVGELDEGKNAFDAME 337
Cdd:PRK07508 202 GATPAEDARLRAALLNDEKNQAENRMIVDLLRNDISRISEVGSLDVPELFDIETYPTVHQMVSRVRARLLPGLGLADIFA 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 338 AAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIR-MAEIEGRKASVRAGAGIVADSVPEKEFF 416
Cdd:PRK07508 282 ALFPCGSITGAPKIRAMEILRELEPGPRDLYCGAIGWIAPDGRMRFNVAIRtLSLFPGGRAVFNVGGGIVFDSTAEAEYE 361
|
250
....*....|..
gi 1365616763 417 EtenkmrAVLKA 428
Cdd:PRK07508 362 E------CLLKA 367
|
|
| PRK06404 |
PRK06404 |
anthranilate synthase component I; Reviewed |
94-426 |
2.89e-54 |
|
anthranilate synthase component I; Reviewed
Pssm-ID: 102361 [Multi-domain] Cd Length: 351 Bit Score: 184.30 E-value: 2.89e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 94 VSYDSVHSIIGGKIEEPSvfgyYPWtfiydhstgalsFFYlreapFDPEALVERARREES---RLEDGGSEVISTDAGME 170
Cdd:PRK06404 54 VTYDFVNACFNNKVEKSG----WPY------------FYS-----MDPETSYKRNIERKSfktVKLKGNYNDISLSLKIK 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 171 EFVEIVRAGkeyiysgDVFQVVLSREYRvrTDLDALEIYKRLVELNPSPYTFILEFEKT-VVGASPETMGSVEGRTFKIN 249
Cdd:PRK06404 113 ELIELIRAG-------EVLQVVISREFE--ANIDFKEKLSEFINNDRSRYVFYYRFGKYrVVGSSPENVFTVNGNIINVD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 250 PIAGTAPrgrtgeeDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQHIESEVVGELdEG 329
Cdd:PRK06404 184 PIAGTYD-------DKILSNELLNSEKDKLEHRMLLDLARNDLSKFADIGTLNVDKVMKIEEFSSVKHLVSQVTAKF-SN 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 330 KNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSlTGDADMAIAIRMAEIEGRKASVRAGAGIVADS 409
Cdd:PRK06404 256 ASYRDILASMFPAGTVSGSPKERAIEIINKYEETPRGPYGGAIGIIS-KGYTDMALVIRTAYSHGNGFRVRAGAGIVKDS 334
|
330
....*....|....*..
gi 1365616763 410 VPEKEFFETENKMRAVL 426
Cdd:PRK06404 335 DPEDEVNEIYSKARSVM 351
|
|
| isochor_syn |
TIGR00543 |
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, ... |
145-429 |
1.57e-47 |
|
isochorismate synthases; This enzyme interconverts chorismate and isochorismate. In E. coli, different loci encode isochorismate synthases for the pathways of menaquinone biosynthesis and enterobactin biosynthesis (via salicilate) and fail to complement each other. Among isochorismate synthases, the N-terminal domain is poorly conserved. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 273127 Cd Length: 351 Bit Score: 166.39 E-value: 1.57e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 145 VERARREESRLEDGGSEVIS-TDAGMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVR--TDLDALEIYKRLVELNPSPYT 221
Cdd:TIGR00543 64 VSSGIRPLRALPEQMTTLTTgEDPDKAAWRTAVEEALENIRQGPLDKVVLARALTLKfaDDIDPIAVLANLRQQYPNAYI 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 222 FILEFEKT--VVGASPETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHvmlvDLARNDVRRVSKPG 299
Cdd:TIGR00543 144 FLLEPPQGgvFLGATPERLLSREKGELLTEALAGTAPRSADPEEDRKLGELLLKDDKNLREH----RLVVEYIRRRLQPI 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 300 SVRLT--RFFDVLKYSHVQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSL 377
Cdd:TIGR00543 220 CTSLDvsETPELLKLANVQHLYTPISARLKDGDSLLDLLKQLHPTPAVGGLPREEALDFIREHEPFDRGLYAAPLGWLDG 299
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1365616763 378 TGDADMAIAIRMAEIEGRKASVRAGAGIVADSVPEKEFFETENKMRAVLKAL 429
Cdd:TIGR00543 300 EGNGEFAVGIRSALVEDGQVRLYAGAGIVADSDPESEWEETELKLQTMLRAL 351
|
|
| salicyl_syn |
TIGR03494 |
salicylate synthase; Members of this protein family are salicylate synthases, bifunctional ... |
159-426 |
3.05e-47 |
|
salicylate synthase; Members of this protein family are salicylate synthases, bifunctional enzymes that make salicylate, in two steps, from chorismate. Members are homologous to anthranilate synthase component I from Trp biosynthesis. Members typically are found in gene regions associated with siderophore or other secondary metabolite biosynthesis.
Pssm-ID: 132533 [Multi-domain] Cd Length: 425 Bit Score: 167.65 E-value: 3.05e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 159 GSEVISTDAGMEEFVEIVRAGKEYIYSGDVFQVVLSREYRV--RTDLDALEIYKRlvELNPSPYTFILEF-EKTVVGASP 235
Cdd:TIGR03494 151 QARAVDTATDPSAYRARVARAVAEIAAGRYHKVILSRAVPLpfAIDFPATLLLGR--RHNTPVRSFLLRLgGIEALGFSP 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 236 ETMGSV-EGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSH 314
Cdd:TIGR03494 229 ELVMSVrADGKVVTEPLAGTRALGGGPEHDKQLRDELLSDSKEIVEHAISVKEAIEELEQVCEPGTVVVEDFMTVRERGS 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 315 VQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEG 394
Cdd:TIGR03494 309 VQHLGSTVSGQLAPSKDAWDAFEVLFPAITASGIPKAAALEAIMRLEKTPRGLYSGAVLLLDADGTLDAALVLRAAYQDS 388
|
250 260 270
....*....|....*....|....*....|..
gi 1365616763 395 RKASVRAGAGIVADSVPEKEFFETENKMRAVL 426
Cdd:TIGR03494 389 GRTWLQAGAGIIAQSTPERELTETCEKLASIA 420
|
|
| PRK06923 |
PRK06923 |
isochorismate synthase DhbC; Validated |
170-433 |
3.01e-43 |
|
isochorismate synthase DhbC; Validated
Pssm-ID: 235886 [Multi-domain] Cd Length: 399 Bit Score: 156.43 E-value: 3.01e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 170 EEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTD--LDALEIYKRLVELNPSPYTFIL-------EFEKTVVGASPETMGS 240
Cdd:PRK06923 122 EVYMNGVKQGIAKIQDGDLKKIVLSRSLDVKSSekIDKQKLLRELAEHNKHGYTFAVnlpkdenENSKTLIGASPELLVS 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 241 VEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKpgSVRLTRFFDVLKYSHVQHIES 320
Cdd:PRK06923 202 RHGMQVISNPLAGSRPRSDDPVEDKRRAEELLSSPKDLHEHAVVVEAVAAALRPYCH--TLHVPEKPSVIHTEAMWHLST 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 321 EVVGEL-DEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKASV 399
Cdd:PRK06923 280 EVKGELkDPNTSSLELAIALHPTPAVCGTPTEEAREAIQQIEPFDREFFTGMLGWSDLNGDGEWIVTIRCAEVEENTLRL 359
|
250 260 270
....*....|....*....|....*....|....
gi 1365616763 400 RAGAGIVADSVPEKEFFETENKMRAVLKALGVRE 433
Cdd:PRK06923 360 YAGAGVVAESKPEDELAETSAKFQTMLKAMGLND 393
|
|
| PRK05877 |
PRK05877 |
aminodeoxychorismate synthase component I; Provisional |
88-421 |
6.45e-41 |
|
aminodeoxychorismate synthase component I; Provisional
Pssm-ID: 235634 [Multi-domain] Cd Length: 405 Bit Score: 150.24 E-value: 6.45e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 88 GGFVGYVSY-DSVHSIIGGKIeePSVFGyyPWTfiyDH-----STGALSFFYLREAPfDPEALVERARREESRLEDGGSe 161
Cdd:PRK05877 63 GGWFGYLSYpDAGADGRPPRI--PEAAG--GWT---DHvlrrdRDGQWWYESLSGAP-DPDWLASALATTRARPAPPCR- 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 162 VISTDAGMEEFVEIVRAGKEYIYSGDVFQVVLSREYRVRTDLDALEIYKRLVE-LNPSPYTFILEFEKTVVGASPETMGS 240
Cdd:PRK05877 134 IDWTPPDRAAHRDGVLACLEAIAAGEVYQACVCTQFTGTVTGSPLDFFADGVArTAPARAAYLAGDWGAVASLSPELFLR 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 241 VEGRTFKINPIAGTAPRGRTGEEdrelekaLLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQHIES 320
Cdd:PRK05877 214 RRGSVVTSSPIKGTLPLDADPSA-------LRASAKDVAENIMIVDLVRNDLGRVARTGTVTVPELLVVRPAPGVWHLVS 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 321 EVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIE-GRKASV 399
Cdd:PRK05877 287 TVSAQVPDELPMSDLLDATFPPASVTGTPKLRARELISQWEPVRRGIYCGTVGLASPVAGCELNVAIRTVEFDaDGNAVL 366
|
330 340
....*....|....*....|..
gi 1365616763 400 RAGAGIVADSVPEKEFFETENK 421
Cdd:PRK05877 367 GVGGGITADSDPDAEWQECLHK 388
|
|
| PRK07912 |
PRK07912 |
salicylate synthase; |
183-422 |
1.14e-35 |
|
salicylate synthase;
Pssm-ID: 169151 [Multi-domain] Cd Length: 449 Bit Score: 136.85 E-value: 1.14e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 183 IYSGDVFQVVLSREYRVRTDLDALEIYKRLVELNPSPYTFILEFEKT-VVGASPETMGSVEG-RTFKINPIAGTAPRGRT 260
Cdd:PRK07912 197 IAAGRYHKVILSRCVEVPFAVDFPATYRLGRRHNTPVRSFLLRLGGIrALGYSPELVTAVRAdGVVITEPLAGTRAFGRG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 261 GEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQHIESEVVGELDEGKNAFDAMEAAF 340
Cdd:PRK07912 277 AAIDRLARDDLESNSKEIVEHAISVRSSLAEITEIAEPGSAAVIDFMTVRERGSVQHLGSTVRGRLDASSDRMDALEALF 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 341 PAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKASVRAGAGIVADSVPEKEFFETEN 420
Cdd:PRK07912 357 PAVTASGIPKAAGVDAIFRLDEAPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCE 436
|
..
gi 1365616763 421 KM 422
Cdd:PRK07912 437 KL 438
|
|
| PRK06772 |
PRK06772 |
salicylate synthase; |
174-431 |
1.28e-34 |
|
salicylate synthase;
Pssm-ID: 102546 [Multi-domain] Cd Length: 434 Bit Score: 133.71 E-value: 1.28e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 174 EIVRAGKEyIYSGDVFQVVLSREYRV--RTDLDALEIYKRlvELNPSPYTFILEFE-KTVVGASPETMGSVEGRTFKINP 250
Cdd:PRK06772 178 QVARAVAE-IRRGEYVKVIVSRAIPLpsRIDMPATLLYGR--QANTPVRSFMFRQEgREALGFSPELVMSVTGNKVVTEP 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 251 IAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSHVQHIESEVVGELDEGK 330
Cdd:PRK06772 255 LAGTRDRMGNPEHNKAKEAELLHDSKEVLEHILSVKEAIAELEAVCQPGSVVVEDLMSVRQRGSVQHLGSGVSGQLAENK 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 331 NAFDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTgDADMAIAIRMAEIEGRKASVRAGAGIVADSV 410
Cdd:PRK06772 335 DAWDAFTVLFPSITASGIPKNAALNAIMQIEKTPRELYSGAILLLDDT-RFDAALVLRSVFQDSQRCWIQAGAGIIAQST 413
|
250 260
....*....|....*....|.
gi 1365616763 411 PEKEFFETENKMRAVLKALGV 431
Cdd:PRK06772 414 PERELTETREKLASIAPYLMV 434
|
|
| PRK07054 |
PRK07054 |
isochorismate synthase; |
140-433 |
3.47e-34 |
|
isochorismate synthase;
Pssm-ID: 235920 [Multi-domain] Cd Length: 475 Bit Score: 132.97 E-value: 3.47e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 140 DPEALverARREESRLEDGGSEVISTDAGMEEFVEI-----------VRAGKEYIYSGDVFQVVLSREY--RVRTDLDAL 206
Cdd:PRK07054 157 DPAAL---AGACCARIERLARPAPAADDDAPRLLRAsalqarewqheVRRAVDAIRGGAFGKVVLARDVlqQYARPVAIG 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 207 EIYKRLVELNPSPYTFILEFEKTV-VGASPETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLV 285
Cdd:PRK07054 234 PLLRRLRLRDPHAHLFAFRRGNACfLGATPERLVRVAAGDLHTHALAGTIARGADPAEDARLGAALMASAKDRLEHALVV 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 286 DLARNdvrrvskpGSVRLTRFFDV------LKYSHVQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIRAMEIIDE 359
Cdd:PRK07054 314 DAIRA--------ALAPLSRALDIpdqpslHRLPRLQHLSTPIRATLAPDATLLQVVAALHPTPAVGGHPRAAALDYIRA 385
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1365616763 360 LERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKASVRAGAGIVADSVPEKEFFETENKMRAVLKALGVRE 433
Cdd:PRK07054 386 HEGFDRGWYAAPIGWLDAHGNGDFAVALRSALITGGACRLFAGCGIVADSEPASEYRETCLKLSGMREALRARD 459
|
|
| PRK07093 |
PRK07093 |
para-aminobenzoate synthase component I; Validated |
180-421 |
6.55e-33 |
|
para-aminobenzoate synthase component I; Validated
Pssm-ID: 235932 [Multi-domain] Cd Length: 323 Bit Score: 126.52 E-value: 6.55e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 180 KEYIYSGDVFQVVLSREYRVRTDLDALEIYKRlvelnpSPYTFILEFEKTVVGASPETMGSVEGRTFKINPIAGTAprgr 259
Cdd:PRK07093 84 QEEIQAGNSYLLNLTYPTPIETNLSLEEIFQA------SKAKYKLLFKDQFVCFSPEPFVRIEDNKISTYPMKGTI---- 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 260 tgeeDRELEKA---LLSDEKERAEHVMLVDLARNDVRRVSKPGSVRLTRFFDVLKYSH--VQHIESEVVGELDEG--KNA 332
Cdd:PRK07093 154 ----DASLPNAeekLLNDEKEFAEHATIVDLLRNDLSMVAKNVRVTRFRYIDKIKTNKgeILQTSSEISGTLPENwqENI 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 333 FDAMEAAFPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYF---SLtgdaDMAIAIRMAEIEGRKASVRAGAGIVADS 409
Cdd:PRK07093 230 GDILAKLLPAGSITGAPKEKTVEIIEQAEGYERGFYTGVFGYFdgeSL----DSAVMIRFIEQENDGLYFKSGGGITIDS 305
|
250
....*....|..
gi 1365616763 410 VPEKEFFETENK 421
Cdd:PRK07093 306 DLKDEYNELIQK 317
|
|
| PRK15016 |
PRK15016 |
isochorismate synthase EntC; Provisional |
138-431 |
1.16e-32 |
|
isochorismate synthase EntC; Provisional
Pssm-ID: 184977 [Multi-domain] Cd Length: 391 Bit Score: 127.30 E-value: 1.16e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 138 PFD---PEAL-VERARREESRLEDGGS----------EVISTDAGMEE--FVEIVRAGKEYIYSGDVFQVVLSREYRVRT 201
Cdd:PRK15016 79 PFDtrqPSSLyIPESWQSFSRQEKQRSarrftrsqslNVVERQAIPEQttFEAMVARAAALTATPQVDKVVLSRLIDITT 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 202 D--LDALEIYKRLVELNPSPYTFILEFEKTVV--GASPETMGSVEGRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKE 277
Cdd:PRK15016 159 DaaIDSGALLERLIAQNPVSYNFHVPLADGGVllGASPELLLRKDGERFSSLPLAGSARRQPDEVLDREAGNRLLASEKD 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 278 RAEHvMLVDLARNDV-----RRVSKPGSVRLtrffdvLKYSHVQHIESEVVGELDEGKNAFDAMEAAFPAGTLTGAPKIR 352
Cdd:PRK15016 239 RHEH-ELVTQAMKEVlrersSELHVPSSPQL------ITTPTLWHLATPFEGKANAQENALTLACLLHPTPALSGFPHQA 311
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1365616763 353 AMEIIDELERSRRKVYGGAVGYFSLTGDADMAIAIRMAEIEGRKASVRAGAGIVADSVPEKEFFETENKMRAVLKALGV 431
Cdd:PRK15016 312 AKQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVKLSTMLNVFGL 390
|
|
| PLN02786 |
PLN02786 |
isochorismate synthase |
185-433 |
2.98e-23 |
|
isochorismate synthase
Pssm-ID: 178383 [Multi-domain] Cd Length: 533 Bit Score: 102.17 E-value: 2.98e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 185 SGDVFQVVLSREYRVRT--DLDALEIYKRLVELNPSPYTFILEFEK--TVVGASPETMGSVEGRTFKINPIAGTAPRGRT 260
Cdd:PLN02786 277 SSPLKKVVLARSSRIITdtDIDPIAWLACLQVEGQNAYQFCLQPPDapAFIGNTPEQLFHRKGLGVCSEALAATRPRGGS 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 261 GEEDRELEKALLSDEKERAEHVMLVDLARNDVRRVSKpgSVRLTRFFDVLKYSHVQHIESEVVGELDEGKNAFDAMEAAF 340
Cdd:PLN02786 357 SARDLQIELDLLTSPKDDLEFSIVRENIREKLEAICD--RVVVEPHKAIRKLARVQHLYAQLAGRLRSEDDEFDILAALH 434
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 341 PAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSlTGDADMAIAIRMAEIE-GRKASVRAGAGIVADSVPEKEFFETE 419
Cdd:PLN02786 435 PTPAVCGHPTEEARLLIAETESFDRGMYAGPVGWFG-GGESEFAVGIRSALVEkGLGALIYAGTGIVEGSNPSSEWNELE 513
|
250
....*....|....
gi 1365616763 420 NKMRAVLKALGVRE 433
Cdd:PLN02786 514 LKISQFTKSLEHES 527
|
|
| PRK15012 |
PRK15012 |
menaquinone-specific isochorismate synthase; Provisional |
171-432 |
1.72e-17 |
|
menaquinone-specific isochorismate synthase; Provisional
Pssm-ID: 184974 [Multi-domain] Cd Length: 431 Bit Score: 84.12 E-value: 1.72e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 171 EFVEIVRAGKEYIYSGDVFQVVLSREyrvrTDL------DALEIYKRLVELNPSPYTFILEF--EKTVVGASPETMGSVE 242
Cdd:PRK15012 171 GWTQLIELATKTIAEGELDKVVLARA----TDLhfaspvNAAAMMAASRRLNLNCYHFYMAFdaENAFLGSSPERLWRRR 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 243 GRTFKINPIAGTAPRGRTGEEDRELEKALLSDEKERAEHVMLVDlarnDVRRvskpgsvRL---TRFFDVL-----KYSH 314
Cdd:PRK15012 247 DKALRTEALAGTVANHPDDKQAQQLGEWLMADDKNQRENMLVVE----DICQ-------RLqadTQTLDVLppqvlRLRK 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 315 VQHIESEVVGELDEGKNAFDAMEAAfPAGTLTGAPKIRAMEIIDELERSRRKVYGGAVGYFSLTgDADMAIAIRMAEIEG 394
Cdd:PRK15012 316 VQHLRRCIWTSLNKADDVICLHQLQ-PTAAVAGLPRDLARQFIARHEPFTREWYAGSAGYLSLQ-QSEFCVSLRSAKVSG 393
|
250 260 270
....*....|....*....|....*....|....*...
gi 1365616763 395 RKASVRAGAGIVADSVPEKEFFETENkmravlKALGVR 432
Cdd:PRK15012 394 NVVRLYAGAGIVRGSDPEQEWQEIDN------KAAGLR 425
|
|
| Anth_synt_I_N |
pfam04715 |
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) ... |
9-124 |
4.44e-11 |
|
Anthranilate synthase component I, N terminal region; Anthranilate synthase (EC:4.1.3.27) catalyzes the first step in the biosynthesis of tryptophan. Component I catalyzes the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family (pfam00425). This region is involved in feedback inhibition by tryptophan. This family also contains a region of Para-aminobenzoate synthase component I (EC 4.1.3.-).
Pssm-ID: 428082 [Multi-domain] Cd Length: 140 Bit Score: 60.40 E-value: 4.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1365616763 9 VDPLKLYSALRDFGMPFMLRSAEkdSRKARFTYISAEP--EFVVEVGEGT--EIDGERVSDERNPLRALKGLMGE-RVEG 83
Cdd:pfam04715 3 LTPLSVYLKLAGEPHSFLLESAE--GGEGRYSFIGINPllTIKSKNGEVSvsGPDGQELEQEDGPLDALRALLARfRIED 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1365616763 84 R-----RFMGGFVGYVSYDSVHSIIggKIEEPSV---------FGYYPWTFIYDH 124
Cdd:pfam04715 81 SpptlpPFSGGLVGYLGYDLVRYIE--KLPRTAPddlnlpdarLILYEDLIVFDH 133
|
|
| |
