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Conserved domains on  [gi|1356572871|ref|WP_105267246|]
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MULTISPECIES: nitrate/nitrite transporter [Escherichia]

Protein Classification

nitrate/nitrite transporter( domain architecture ID 11454872)

nitrate/nitrite transporter is a major facilitator superfamily (MFS) transporter that facilitates the transport of nitrate (import)/nitrite (export)

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  25959928|18537473|23403214|26758938|26098515
SCOP:  3000310
TCDB:  2.A.1.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
7-415 2.05e-37

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


:

Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 140.02  E-value: 2.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871   7 RRWITLAIISFSGGVSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITG 86
Cdd:COG2223     2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  87 LLGLLMATYPPLWVMLCIQVAFAITTIlMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFapdd 166
Cdd:COG2223    82 IGLLLLALAVSYWLLLLLGLLLGIGGG-GSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 167 saSLKTVIIIYSVVYILLGILCWFFVSDnnnlRNANNEEKQSFQLSDILAVLRISTTWYCSMVIFGVFT-IYAILSYSTN 245
Cdd:COG2223   157 --GWRNAFLILGILLLVVAVLAWLFLRD----PPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGsFIGFSSWLPP 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 246 YLTEMYGMSLVAASYMGIVINkIFRALCGPLGGIITTYSKVKSPTRVIQILSVLGLLALTALlitnsnPQSVAMGIGLIL 325
Cdd:COG2223   231 YLVDQFGLSAATAGLLAALFA-LLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA------LGSLWLFLVLFL 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 326 LLGFTCYASRGLYWACPGEaRTPSYIMGTTVGICSVIGFLPDVFVYPIIGYWQDtlpAAEAYRNMWLMGMAALGMVIVFT 405
Cdd:COG2223   304 LLGLALGGGNGAVFALVPD-IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD---ATGSYTAAFLVFAVLALVALVLT 379

                         410
                  ....*....|
gi 1356572871 406 FLLFQKIRTA 415
Cdd:COG2223   380 LLLYRRPRRA 389
 
Name Accession Description Interval E-value
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
7-415 2.05e-37

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 140.02  E-value: 2.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871   7 RRWITLAIISFSGGVSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITG 86
Cdd:COG2223     2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  87 LLGLLMATYPPLWVMLCIQVAFAITTIlMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFapdd 166
Cdd:COG2223    82 IGLLLLALAVSYWLLLLLGLLLGIGGG-GSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 167 saSLKTVIIIYSVVYILLGILCWFFVSDnnnlRNANNEEKQSFQLSDILAVLRISTTWYCSMVIFGVFT-IYAILSYSTN 245
Cdd:COG2223   157 --GWRNAFLILGILLLVVAVLAWLFLRD----PPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGsFIGFSSWLPP 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 246 YLTEMYGMSLVAASYMGIVINkIFRALCGPLGGIITTYSKVKSPTRVIQILSVLGLLALTALlitnsnPQSVAMGIGLIL 325
Cdd:COG2223   231 YLVDQFGLSAATAGLLAALFA-LLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA------LGSLWLFLVLFL 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 326 LLGFTCYASRGLYWACPGEaRTPSYIMGTTVGICSVIGFLPDVFVYPIIGYWQDtlpAAEAYRNMWLMGMAALGMVIVFT 405
Cdd:COG2223   304 LLGLALGGGNGAVFALVPD-IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD---ATGSYTAAFLVFAVLALVALVLT 379

                         410
                  ....*....|
gi 1356572871 406 FLLFQKIRTA 415
Cdd:COG2223   380 LLLYRRPRRA 389
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 15-406 5.48e-27

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 110.98  E-value: 5.48e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  15 ISFSGGVSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMAT 94
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  95 YPPLWVMLCIQVAFAITTILMLWSVSIKAASLLGDHsEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFapddSASLKTVI 174
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPER-ERGRALGLLQAFGSVGGILGPLLGGILASSL----GFGWRAVF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 175 IIYSVVYILLGILCWFFVSDN-NNLRNANNEEKQSFQLSDILAVLRISTTWYCSMVIFGVFTIYAILSYSTNYLTEMYGM 253
Cdd:cd06174   156 LIAAALALLAAILLLLVVPDPpESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 254 SLVAASYMGIVINKIFRALCGPLGGIITTYskvKSPTRVIQILSVLGLLALTALLITNSNPQSvamGIGLILLLGFTCYA 333
Cdd:cd06174   236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDR---LIGRKPLLLIGLLLMALGLALLLLAPSLLL---LLLLLLLLGFGLGG 309

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1356572871 334 SRGLYWACPGEArTPSYIMGTTVGICSVIGFLPDVFVYPIIGYWQDtlpAAEAYRNMWLMGMAALGMVIVFTF 406
Cdd:cd06174   310 LLPLSFALIAEL-FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA---ATFGLTGAFLVLAVLLLLAAILLL 378
MFS_1 pfam07690
Major Facilitator Superfamily;
21-365 5.19e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 66.67  E-value: 5.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  21 VSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWV 100
Cdd:pfam07690   8 AALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 101 MLCIQVAFAITTiLMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFapddsaSLKTVIIIYSVV 180
Cdd:pfam07690  88 LLVLRVLQGLGA-GALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF------GWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 181 YILLGILCWFFVSDNNNLRNANNEEKQSFQLSDILAVLRISTTWyCSMVIFGVFTIYAILSYSTNYLTEMYGMSLVAASY 260
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 261 MGIVINKIFRALCGPLGGIITTYSKVKSPTRVIQILSVLGLLALTALLITNSnpqsvAMGIGLILLLGFTCYASRGLYWA 340
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSS-----LWLLLALLLLGFGFGLVFPALNA 314

                         330       340
                  ....*....|....*....|....*
gi 1356572871 341 CPGEaRTPSYIMGTTVGICSVIGFL 365
Cdd:pfam07690 315 LVSD-LAPKEERGTASGLYNTAGSL 338
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 41-376 3.40e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 45.83  E-value: 3.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  41 GFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLciqVAFAITTIL--MLWS 118
Cdd:TIGR00881  26 GLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA---ALWALNGIFqgMGWP 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 119 VSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMwvfsrFAPDDSASLKTVIIIYSVVYILLGILCWFFVSD---- 194
Cdd:TIGR00881 103 PCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVL-----FGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDspqs 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 195 ----------NNNLRNANNEEKQSFQLSDILA--VLRISTTWYCSMVIFGVF-TIYAILSYSTNYLTEMYGMSLVAASYM 261
Cdd:TIGR00881 178 cglppaeempNEEPDGDAEKKEEELTKKQIFLqyVLLNKVLWYISLGYVFVYvVRTGILDWSPLYLTQEKGFSKEKASWA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 262 ---------------GIVINKIFRALCGPLGGIITTyskvksptrviqilsVLGLLALTALLITNSNPQSVAMgigLILL 326
Cdd:TIGR00881 258 ftlyelgglvgtllaGWLSDKLFNGRRGPLAVFFMA---------------LIIVSLLVYWLNPAANPLMDLI---CLFA 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1356572871 327 LGFTCYASRGLYWACPGEArTPSYIMGTTVGICSVIGFLPDVFVYPIIGY 376
Cdd:TIGR00881 320 LGFLVYGPQMLIGVIASEL-APKKAAGTAAGFVGFFAYLGGILAGLPLGY 368
 
Name Accession Description Interval E-value
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
7-415 2.05e-37

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 140.02  E-value: 2.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871   7 RRWITLAIISFSGGVSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITG 86
Cdd:COG2223     2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  87 LLGLLMATYPPLWVMLCIQVAFAITTIlMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFapdd 166
Cdd:COG2223    82 IGLLLLALAVSYWLLLLLGLLLGIGGG-GSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 167 saSLKTVIIIYSVVYILLGILCWFFVSDnnnlRNANNEEKQSFQLSDILAVLRISTTWYCSMVIFGVFT-IYAILSYSTN 245
Cdd:COG2223   157 --GWRNAFLILGILLLVVAVLAWLFLRD----PPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGsFIGFSSWLPP 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 246 YLTEMYGMSLVAASYMGIVINkIFRALCGPLGGIITTYSKVKSPTRVIQILSVLGLLALTALlitnsnPQSVAMGIGLIL 325
Cdd:COG2223   231 YLVDQFGLSAATAGLLAALFA-LLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA------LGSLWLFLVLFL 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 326 LLGFTCYASRGLYWACPGEaRTPSYIMGTTVGICSVIGFLPDVFVYPIIGYWQDtlpAAEAYRNMWLMGMAALGMVIVFT 405
Cdd:COG2223   304 LLGLALGGGNGAVFALVPD-IFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD---ATGSYTAAFLVFAVLALVALVLT 379

                         410
                  ....*....|
gi 1356572871 406 FLLFQKIRTA 415
Cdd:COG2223   380 LLLYRRPRRA 389
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 15-406 5.48e-27

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 110.98  E-value: 5.48e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  15 ISFSGGVSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMAT 94
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  95 YPPLWVMLCIQVAFAITTILMLWSVSIKAASLLGDHsEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFapddSASLKTVI 174
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPER-ERGRALGLLQAFGSVGGILGPLLGGILASSL----GFGWRAVF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 175 IIYSVVYILLGILCWFFVSDN-NNLRNANNEEKQSFQLSDILAVLRISTTWYCSMVIFGVFTIYAILSYSTNYLTEMYGM 253
Cdd:cd06174   156 LIAAALALLAAILLLLVVPDPpESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGG 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 254 SLVAASYMGIVINKIFRALCGPLGGIITTYskvKSPTRVIQILSVLGLLALTALLITNSNPQSvamGIGLILLLGFTCYA 333
Cdd:cd06174   236 LSVAVAGLLLSLFGLAGALGSLLLGLLSDR---LIGRKPLLLIGLLLMALGLALLLLAPSLLL---LLLLLLLLGFGLGG 309

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1356572871 334 SRGLYWACPGEArTPSYIMGTTVGICSVIGFLPDVFVYPIIGYWQDtlpAAEAYRNMWLMGMAALGMVIVFTF 406
Cdd:cd06174   310 LLPLSFALIAEL-FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA---ATFGLTGAFLVLAVLLLLAAILLL 378
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
5-413 5.81e-25

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 104.95  E-value: 5.81e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871   5 SYRRWITLAIISFSGGVSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMII 84
Cdd:COG2271     5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  85 TGLLGLLMATYPPLWVMLCIQVAFAITTiLMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFap 164
Cdd:COG2271    85 WGLATLLFGFATSFWQLLLLRFLLGLGE-AGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-- 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 165 ddsaSLKTVIIIYSVVYILLGILcwffvsdnnnlrnanneekqsfqlsdilavlrisTTWYCSMVIFGV-FTIYAILSYS 243
Cdd:COG2271   162 ----GWRAAFLILGLPGLLLALL----------------------------------RFWLLALAYFLVyFALYGFLTWL 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 244 TNYLTEMYGMSLVAASYMGIVINkIFRALCGPLGGIITtySKVKSPTRVIQILSVLGLLALTALLITNSNPqsvAMGIGL 323
Cdd:COG2271   204 PTYLVEVRGLSLAQAGLLLSLPF-LAGIVGSLLGGWLS--DRLGRRRKLVLAIGLLLAALALLLLALLPSP---ALAIAL 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 324 ILLLGFTCYASRGLYWACPGEArTPSYIMGTTVGICSVIGFLPDVFVYPIIGYWQDTLpaaeAYRNMWLMGMAALGMVIV 403
Cdd:COG2271   278 LFLAGFGLGGAFGLLWALAAEL-FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT----GYQAAFLLLAALALLAAL 352

                         410
                  ....*....|
gi 1356572871 404 FTFLLFQKIR 413
Cdd:COG2271   353 LALLLLRETR 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-365 7.47e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 69.23  E-value: 7.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871   1 MQHNSYRRWITLAIISFSGGVSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITS 80
Cdd:COG2814     1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  81 AMIITGLLGLLMATYPPLWVMLCIQVAFAITTIlMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFS 160
Cdd:COG2814    81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAG-ALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 161 RFapddsaSLKTVIIIYSVVYILLGILCWFFVSDnnnlrnaNNEEKQSFQLSDILAVLRISTTWYCSMVIFGV-FTIYAI 239
Cdd:COG2814   160 LF------GWRWVFLVNAVLALLALLLLLRLLPE-------SRPAARARLRGSLRELLRRPRLLLLLLLAFLLgFGFFAL 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 240 LSYSTNYLTEMYGMSLVAASYMGIVINkIFRALCGPLGGIIttySKVKSPTRVIQILSVLGLLALTALLITnsnpQSVAM 319
Cdd:COG2814   227 FTYLPLYLQEVLGLSASAAGLLLALFG-LGGVLGALLAGRL---ADRFGRRRLLLIGLLLLALGLLLLALA----GSLWL 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1356572871 320 GIGLILLLGFTCYASRGLYWACPGEaRTPSYIMGTTVGICSVIGFL 365
Cdd:COG2814   299 LLLALFLLGFGFGLLFPLLQALVAE-LAPPEARGRASGLYNSAFFL 343
MFS_1 pfam07690
Major Facilitator Superfamily;
21-365 5.19e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 66.67  E-value: 5.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  21 VSFDLAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWV 100
Cdd:pfam07690   8 AALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 101 MLCIQVAFAITTiLMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFapddsaSLKTVIIIYSVV 180
Cdd:pfam07690  88 LLVLRVLQGLGA-GALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF------GWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 181 YILLGILCWFFVSDNNNLRNANNEEKQSFQLSDILAVLRISTTWyCSMVIFGVFTIYAILSYSTNYLTEMYGMSLVAASY 260
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 261 MGIVINKIFRALCGPLGGIITTYSKVKSPTRVIQILSVLGLLALTALLITNSnpqsvAMGIGLILLLGFTCYASRGLYWA 340
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSS-----LWLLLALLLLGFGFGLVFPALNA 314

                         330       340
                  ....*....|....*....|....*
gi 1356572871 341 CPGEaRTPSYIMGTTVGICSVIGFL 365
Cdd:pfam07690 315 LVSD-LAPKEERGTASGLYNTAGSL 338
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-261 2.72e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 64.88  E-value: 2.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871   1 MQHNSYRRWITLAIISF-SGGVSFDLAYLRyiyqIP-MAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMI 78
Cdd:COG0738     1 MSKKNYRRALIAIYLLFfLWGFATALWGPL----IPaLKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  79 TSAMIITGLLGLLMATYPPLWVMLCiqVAFAITTILMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWV 158
Cdd:COG0738    77 LLGLLLMALGLLLFALAPSYPLLLL--ALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 159 FSRfapDDSASLKTVIIIYSVVYILLGILCWFFvsdnNNLRNANNEEKQSFQLSDILAVLRISTTWYCSMVIF-GVFTIY 237
Cdd:COG0738   155 ILL---GLSLSWHLPYLILAVLLLLLALLFLRS----KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFlYVGAEG 227

                         250       260
                  ....*....|....*....|....
gi 1356572871 238 AILSYSTNYLTEMYGMSLVAASYM 261
Cdd:COG0738   228 AIGDWLPLYLKDVLGLSEATAALG 251
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 37-280 5.46e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 63.75  E-value: 5.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  37 AKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQVAFAITTIlML 116
Cdd:cd17325    23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASA-AV 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 117 WSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFapddsaSLKTVIIIYSVVYILLGILCWFFVSDNN 196
Cdd:cd17325   102 WPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL------GYRAPFLVCAALALLALVLALLLLPEPR 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 197 NLRNANNEEKQSFQLSDILAVLRISTTWYCSMVIFGVFTIYAILSYSTNYLTEMYGMSLVAASYMGIVINkIFRALCGPL 276
Cdd:cd17325   176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG-LASALSQPP 254


                  ....
gi 1356572871 277 GGII 280
Cdd:cd17325   255 AGKL 258
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 41-376 8.11e-09

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 56.90  E-value: 8.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  41 GFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQVAFAITTIlMLWSVS 120
Cdd:cd17312    34 GLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQS-MGWPPC 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 121 IKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFapddsaSLKTVIIIYSVVYILLGILCWFFVSDnnnlrn 200
Cdd:cd17312   113 VKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY------GWRAAFLVPGIVGLVVAIILFFFLRD------ 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 201 anneekqsfqlsdilavlRISTTWYCSMVIFGVFTI-YAILSYSTNYLTEMYGMSLVAASYMGIVInkifrALCGPLGGI 279
Cdd:cd17312   181 ------------------SPPYVWVLSLAYAFVYIVrYACLDWGPLYLYEVKGYSLIDAGWFSSLY-----EVGGIAGTI 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 280 ITTY--SKVKSPTRVIQILSVLGLLALTALLITnSNPQSVAMGIGLILLLGFTCYASRGLYWACPGEARTPSYIMGTTVG 357
Cdd:cd17312   238 LAGLlsDKLFGGRRAPIAVIYMLLMTLSLALFW-FFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATG 316

                         330
                  ....*....|....*....
gi 1356572871 358 ICSVIGFLPDVFVYPIIGY 376
Cdd:cd17312   317 FVGLFGYLGASLAGLPLGY 335
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
5-413 1.23e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.83  E-value: 1.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871   5 SYRRWITLAIISFSGGVSFDL--AYLRYIYQIpmakFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRK-----M 77
Cdd:COG2211     8 SLKEKLAYGLGDLGLNLAFGLlsAYLLYFYTD----VLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpW 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  78 ITSAMIITGLLGLLMATYPPLWVMLCIqVAFAITTILMLWSVSIK-------AASLLGDHSEQGKIMGWMEGLRGVGVMS 150
Cdd:COG2211    84 ILIGAIPLALSFVLLFTAPDLSPTGKL-IYALVTYLLLGLAYTLVnipysalGAELTPDYEERTRLSSWRFAFAGLGGLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 151 LAVFTMWVFSRFAPDDSASLKTVIIIYSVVYILLGILCWFFVSDnnnlrnANNEEKQSFQLSDILAVLRISTTW--YCSM 228
Cdd:COG2211   163 ASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKE------RPVPEEEKVSLKESLKALLKNRPFllLLLA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 229 VIFGVFTIYAILSYSTNYLTEMYGMSLVAASYMGIVINkIFRALCGPLGGIITTYSKVKSPTRVIQILSVLGLLALTAll 308
Cdd:COG2211   237 YLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYF-LAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF-- 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 309 itnSNPQSVAMGIGLILLLGFTCYASRGLYWAC------PGEARTPSYIMGTTVGICSVIGFLPDV-------FVYPIIG 375
Cdd:COG2211   314 ---LGPGNLWLLLVLAALAGIGLGAILVLPWAMladvvdYDEWKTGRRREGLYFGIFTFAIKLGQAlagalagLLLALFG 390

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1356572871 376 YWQDTLPAAEAYRNMWLM--GMAALGMVIVFTFLLFQKIR 413
Cdd:COG2211   391 YVAGAAQSPSALTGIRLLffLLPAVLLLLAALLLLFYPLT 430
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 35-376 1.13e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 53.34  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  35 PMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQVAFAITTIL 114
Cdd:cd17319    28 TIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAG 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 115 MlWSVSIKAASLLGDHSEQGKIMG-WMEGLRGVGVMSLAVFTMWVfsrfapdDSASLKTVIIIYSVVYILLGILCWFFVs 193
Cdd:cd17319   108 F-FPGAIKALAEWFPARERGRATGlFNSGAPLGAAIGPPLSGWLL-------LLFGWRWAFIIEGLLGLLLAVLWWFYL- 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 194 dnnnlrnanneekqsfqlsdilavlriSTTWYCSMVIFGV-FTIYAILSYSTNYLTEMYGMSLVAASYMGIVInkifrAL 272
Cdd:cd17319   179 ---------------------------RQVWGLALGYFGInYALYGLLTWLPTYLKQARGFSLKQVGLLAAIP-----FL 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 273 CGPLGGIITTYSKVKSPTRVIQILSVLGLLALTALLITNSNPQSVAMGIGLILLLGFTCYASRGLYWACPGEArTPSYIM 352
Cdd:cd17319   227 AGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADL-LPGEAA 305

                         330       340
                  ....*....|....*....|....
gi 1356572871 353 GTTVGICSVIGFLPDVFVYPIIGY 376
Cdd:cd17319   306 ATAGGLINSGGNLGGFVAPLLIGY 329
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 5-192 2.95e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.19  E-value: 2.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871   5 SYRRWITLAIISFSGGVSFdlAYLRYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMII 84
Cdd:cd17325   197 RDRRLLALFLAIFVLAFAF--GALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  85 TGLLGLLMATYPPLWVMLCIQVAFAITTIlMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFap 164
Cdd:cd17325   275 SAVALLLLPLATSFWLLLLLLALLGLGLG-LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF-- 351

                         170       180
                  ....*....|....*....|....*...
gi 1356572871 165 ddsaSLKTVIIIYSVVYILLGILCWFFV 192
Cdd:cd17325   352 ----GFATPFLAAAALLLLAAVLFLLLR 375
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 41-259 8.43e-07

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 50.70  E-value: 8.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  41 GFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPplWVMLCIQVAFAITTIL-----M 115
Cdd:cd17345    34 GLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVP--SATSSVGLMFILLFLNgwfqgM 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 116 LWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVFSRFAPDDsasLKTVIIIYSVVYILLGILCWFFVSD- 194
Cdd:cd17345   112 GWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGW---WRGAFIFPAIIAIIVAVIVLFLGKDt 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 195 ------------NNNLRNANNEEKQSFQLS--DILA--VLRISTTWYCSMV-IFGVFTIYAILSYSTNYLTEMYGMSLVA 257
Cdd:cd17345   189 peseglppieeyKGDYPEEADGEEEEQELSawEIFVkyVLKNKLLWYIAIAnVFVYLVRYGILDWAPTYLSEVKGFSKAQ 268


                  ..
gi 1356572871 258 AS 259
Cdd:cd17345   269 AM 270
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-147 1.14e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.36  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871   5 SYRRWITLAIISFSGGVSFDLAYlrYIYQIPMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMII 84
Cdd:COG2814   205 RRPRLLLLLLLAFLLGFGFFALF--TYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1356572871  85 TGLLGLLMATYPPLWVMLCIQVAFAItTILMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVG 147
Cdd:COG2814   283 LALGLLLLALAGSLWLLLLALFLLGF-GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 35-403 1.46e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 49.93  E-value: 1.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  35 PMAKFM----GFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQVafai 110
Cdd:cd17475    17 ALAPFLqedlHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLF---- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 111 ttILMLWSVSIKAASllgdhseqGK-IMGWM-EGLRG-----------VGVMSLAVFTMWVFSRFapddsaSLKTVIIIY 177
Cdd:cd17475    93 --LVGAGYGSVQPGG--------GRaIMRWFpPRERGlamgirqtgvpLGGALAAALLPPLALHY------GWRAAFVVA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 178 SVVYILLGILCWFFVSDnnNLRNANNEEKQSFQLSDILAVLRISTTWYCSMVIFG-VFTIYAILSYSTNYLTEMYGMSLV 256
Cdd:cd17475   157 GLVSILAAVLFWLFYRE--PPAASAATESASTLLRSLKEVLRNRDVWLIAIAGALlVAPQFALLTFLLLFLHDHLGLSVV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 257 AASYMGIVINkifraLCGPLG----GIITTYSKVKSPTRVIQILSVLGLLALTALLITNSNPQSVAMGIGLIlLLGFTCY 332
Cdd:cd17475   235 AAGALLAVAQ-----LGGALGriglGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLI-LLGLFAI 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1356572871 333 ASRGLYWACPGEARTPSYImGTTVGICSVIGFLPDVFVYPIIGYWQDtlpAAEAYRNMW--LMGMAALGMVIV 403
Cdd:cd17475   309 GWNGLYLTLVAESAGPEQA-GTALGLANTINFIGIAIGPPLFGLLVD---ATHSYAPAWlaLALLLVLAALLL 377
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 36-337 4.75e-06

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 48.40  E-value: 4.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  36 MAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKM--ITSAMIITGLLGLLMATYPPlWVMLCIqvAFAITTI 113
Cdd:cd17341    25 IRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVfiASLLLLLIPLLALALAVSSY-WGLLVL--GFLLGFA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 114 LMLWSVSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMWVF-SRFAPDDSASLKTVIIIYSVVYILLGILCWFFV 192
Cdd:cd17341   102 GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAgAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFG 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 193 SDNNNLRnanneEKQSFQLSDILAVLRISTTWYCSMVIFGVFTIYAILS-YSTNYLTEMYGMSLVAASY---MGIVINKI 268
Cdd:cd17341   182 DDLPTGK-----ASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSnVLPTYFKTRFGLPLVTAGIlaaLFPLAGAL 256

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 269 FRalcgPLGGIIttySKVKSPTRVIQILSVLGLLALTALLITNSNP-QSVAMGIGLILLLGFTCYASRGL 337
Cdd:cd17341   257 AR----PAGGWL---SDRFGGRRRLWWLFIVMTIGAALLSLSLPTSgTNLVLFLALFVALGLGAGAGNGS 319
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 35-194 2.76e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.05  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  35 PMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQ----VAFAI 110
Cdd:cd17489    21 LYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRlihgIGWGA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 111 -TTILMLWSVSIKAASLLgdhseqGKIMGWMeGLRGVGVMSLAVFT-MWVFSRFAPDdsaslktVIIIYSVVYILLGILC 188
Cdd:cd17489   101 fTTAAATLVADIIPPSRR------GEGIGYY-GLATTLAMALGPALgLFLYQHLGFA-------VLFIVAAVLALLALLL 166


                  ....*.
gi 1356572871 189 WFFVSD 194
Cdd:cd17489   167 VFLVKD 172
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 41-376 3.40e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 45.83  E-value: 3.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  41 GFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLciqVAFAITTIL--MLWS 118
Cdd:TIGR00881  26 GLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA---ALWALNGIFqgMGWP 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 119 VSIKAASLLGDHSEQGKIMGWMEGLRGVGVMSLAVFTMwvfsrFAPDDSASLKTVIIIYSVVYILLGILCWFFVSD---- 194
Cdd:TIGR00881 103 PCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVL-----FGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDspqs 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 195 ----------NNNLRNANNEEKQSFQLSDILA--VLRISTTWYCSMVIFGVF-TIYAILSYSTNYLTEMYGMSLVAASYM 261
Cdd:TIGR00881 178 cglppaeempNEEPDGDAEKKEEELTKKQIFLqyVLLNKVLWYISLGYVFVYvVRTGILDWSPLYLTQEKGFSKEKASWA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 262 ---------------GIVINKIFRALCGPLGGIITTyskvksptrviqilsVLGLLALTALLITNSNPQSVAMgigLILL 326
Cdd:TIGR00881 258 ftlyelgglvgtllaGWLSDKLFNGRRGPLAVFFMA---------------LIIVSLLVYWLNPAANPLMDLI---CLFA 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1356572871 327 LGFTCYASRGLYWACPGEArTPSYIMGTTVGICSVIGFLPDVFVYPIIGY 376
Cdd:TIGR00881 320 LGFLVYGPQMLIGVIASEL-APKKAAGTAAGFVGFFAYLGGILAGLPLGY 368
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
3-191 3.45e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.66  E-value: 3.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871   3 HNSYRRWITLAIISFSGGVSFDLAYLRYIyqipMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAM 82
Cdd:COG2211   226 KNRPFLLLLLAYLLFFLALALVAALLLYY----FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGL 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  83 IITGLLGLLMATYPP--LWVMLCIQVAFAI---TTILMLWSV---SIKAASLLGDHSEQGKIMGWMEGLRGVGVM--SLA 152
Cdd:COG2211   302 LLAALGLLLLFFLGPgnLWLLLVLAALAGIglgAILVLPWAMladVVDYDEWKTGRRREGLYFGIFTFAIKLGQAlaGAL 381

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1356572871 153 VFTMWVFSRFAPDDSAS------LKTVIIIYSVVYILLGILCWFF 191
Cdd:COG2211   382 AGLLLALFGYVAGAAQSpsaltgIRLLFFLLPAVLLLLAALLLLF 426
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 41-260 2.03e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 43.08  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  41 GFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQV--AFAITTILMLWS 118
Cdd:cd17333    27 NLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFlaGLGAGILDTGAN 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 119 VSIKAASllgdHSEQGKIMGWMEGLRGVGVMSLAVFTmwvfsRFAPDDSASLKTVIIIYSVVYILLGILCWFFVSDNNNL 198
Cdd:cd17333   107 TFVGALF----EESSATRLNVLHGFFGLGALIGPLIA-----TSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPS 177

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1356572871 199 RNANNEEKQSFQLSDILAVLRISTTWYCSMVIFGVFTIYAILSYSTNYLTEMYGMSLVAASY 260
Cdd:cd17333   178 ARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGY 239
MFS_NHS cd06177
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ...
 36-111 6.25e-04

Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340866 [Multi-domain]  Cd Length: 386  Bit Score: 41.85  E-value: 6.25e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1356572871  36 MAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADK-FSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQVAFAIT 111
Cdd:cd06177    24 MGSTLGFTGAQIGAVYSTTGIAAIIMPFFLGIIADRfFAAEKVLAVLHLIGAAALFYAATVTDFSVFFWVMLLYSLC 100
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 35-259 6.43e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.77  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  35 PMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQVAFAItTIL 114
Cdd:cd17324    24 DIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGL-AHG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871 115 MLWSVSIKAASLLGDHSEQGKIMGWMeglrgVGVMSLAVFTMWVFSRFApDDSASLKTVIIIYSVVYILLGILCWFFVSD 194
Cdd:cd17324   103 GFWAIAAAYAADLVPPEKRGRAIGLV-----FSGLTLGLVLGRPLGGLL-GQLLGWRAAFLAIAVLALLAALLLWRLLPS 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1356572871 195 nnnlrNANNEEKQSFQLSDILAVLRISTTWYCSMVIFGVFT-IYAILSYSTNYLTEMYGMSLVAAS 259
Cdd:cd17324   177 -----LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGgFFALYTYLAPFLTDVPGFSSSAII 237
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 40-102 1.62e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.23  E-value: 1.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1356572871  40 MGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVML 102
Cdd:cd17477   218 LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLAL 280
MFS_1_like pfam12832
MFS_1 like family; This family contains proteins related to the MFS superfamily.
 41-121 2.33e-03

MFS_1 like family; This family contains proteins related to the MFS superfamily.


Pssm-ID: 432817 [Multi-domain]  Cd Length: 362  Bit Score: 39.92  E-value: 2.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  41 GFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPP-LWVMLCIQVAFAITTILMlWSV 119
Cdd:pfam12832 232 GASNTLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFVEnPWLVLPIQFLHAISFGLT-HAA 310


                  ..
gi 1356572871 120 SI 121
Cdd:pfam12832 311 AI 312
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 40-116 2.93e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.46  E-value: 2.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1356572871  40 MGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVMLCIQVAFAITTILML 116
Cdd:cd17477    26 EGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLF 102
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 36-102 5.45e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 5.45e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1356572871  36 MAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVML 102
Cdd:cd17474    25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLL 91
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
35-115 8.03e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 38.32  E-value: 8.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871  35 PMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIITGLLGLLMATYPPLWVML----CIQVAFAI 110
Cdd:COG2807    43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLagtaLIGAGIAV 122


                  ....*
gi 1356572871 111 TTILM 115
Cdd:COG2807   123 GNVLL 127
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 6-113 8.75e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 37.98  E-value: 8.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356572871   6 YRRWITLAIISFSGGVSFDLAYLRyiyqipMAKFMGFSNTEIGLIMSTFGIAAIILYAPSGVIADKFSHRKMITSAMIIT 85
Cdd:cd17329     2 WVLLIGSFLNRLGFFMVWPFMAIY------LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLR 75

                          90       100
                  ....*....|....*....|....*...
gi 1356572871  86 GLLGLLMATYPPLWVMLciqVAFAITTI 113
Cdd:cd17329    76 ALGFALLGFAHSPWLFA---IALVLTGF 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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