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Conserved domains on  [gi|1356004211|ref|WP_105186900|]
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RimK family alpha-L-glutamate ligase [Micropruina glycogenica]

Protein Classification

RimK family alpha-L-glutamate ligase( domain architecture ID 11415139)

RimK family alpha-L-glutamate ligase, similar to Escherichia coli RimK which can catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected Glu residues

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 29-187 2.14e-14

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


:

Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 73.05  E-value: 2.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356004211  29 VGPITVDGVTHTMAAERLTIEPFDLTDPvrtPLVIDRLAyWYYHPREWLKKAALvNGTYLLNSPFTFQ-SMEKHSAYCAM 107
Cdd:COG0189    30 VEVIDPDDLTLDLGRAPELYRGEDLSEF---DAVLPRID-PPFYGLALLRQLEA-AGVPVVNDPEAIRrARDKLFTLQLL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356004211 108 LRLGLKVPKTVLVPYKNpvdnvrwaytsskynkgfDLEAIAADLGYPLYMKPFDGGGWRGVSRINNADDLRRAYDASGEM 187
Cdd:COG0189   105 ARAGIPVPPTLVTRDPD------------------DLRAFLEELGGPVVLKPLDGSGGRGVFLVEDEDALESILEALTEL 166
 
Name Accession Description Interval E-value
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 29-187 2.14e-14

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 73.05  E-value: 2.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356004211  29 VGPITVDGVTHTMAAERLTIEPFDLTDPvrtPLVIDRLAyWYYHPREWLKKAALvNGTYLLNSPFTFQ-SMEKHSAYCAM 107
Cdd:COG0189    30 VEVIDPDDLTLDLGRAPELYRGEDLSEF---DAVLPRID-PPFYGLALLRQLEA-AGVPVVNDPEAIRrARDKLFTLQLL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356004211 108 LRLGLKVPKTVLVPYKNpvdnvrwaytsskynkgfDLEAIAADLGYPLYMKPFDGGGWRGVSRINNADDLRRAYDASGEM 187
Cdd:COG0189   105 ARAGIPVPPTLVTRDPD------------------DLRAFLEELGGPVVLKPLDGSGGRGVFLVEDEDALESILEALTEL 166
PRK07178 PRK07178
acetyl-CoA carboxylase biotin carboxylase subunit;
146-182 1.37e-04

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 180865 [Multi-domain]  Cd Length: 472  Bit Score: 43.94  E-value: 1.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1356004211 146 AIAADLGYPLYMKPFDGGGWRGVSRINNADDLRRAYD 182
Cdd:PRK07178  145 AEAERIGYPVMLKATSGGGGRGIRRCNSREELEQNFP 181
ATP-grasp_4 pfam13535
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 151-183 2.26e-03

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 316093 [Multi-domain]  Cd Length: 160  Bit Score: 38.42  E-value: 2.26e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1356004211 151 LGYPLYMKPFDGGGWRGVSRINNADDLRRAYDA 183
Cdd:pfam13535   1 IPYPCVIKPSVGFFSVGVYKINNREEWKAAFAA 33
 
Name Accession Description Interval E-value
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 29-187 2.14e-14

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 73.05  E-value: 2.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356004211  29 VGPITVDGVTHTMAAERLTIEPFDLTDPvrtPLVIDRLAyWYYHPREWLKKAALvNGTYLLNSPFTFQ-SMEKHSAYCAM 107
Cdd:COG0189    30 VEVIDPDDLTLDLGRAPELYRGEDLSEF---DAVLPRID-PPFYGLALLRQLEA-AGVPVVNDPEAIRrARDKLFTLQLL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356004211 108 LRLGLKVPKTVLVPYKNpvdnvrwaytsskynkgfDLEAIAADLGYPLYMKPFDGGGWRGVSRINNADDLRRAYDASGEM 187
Cdd:COG0189   105 ARAGIPVPPTLVTRDPD------------------DLRAFLEELGGPVVLKPLDGSGGRGVFLVEDEDALESILEALTEL 166
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
 100-183 2.79e-07

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 51.41  E-value: 2.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356004211 100 KHSAYCAMLRLGLKVPKTVLVPyknPVDnvrwaytsskynkgfDLEAIAADLGYPLYMKPFDGGGWRGVSRINNADDLRR 179
Cdd:COG0439    55 KVLMREALAAAGVPVPGFALVD---SPE---------------EALAFAEEIGYPVVVKPADGAGSRGVRVVRDEEELEA 116


                  ....
gi 1356004211 180 AYDA 183
Cdd:COG0439   117 ALAE 120
DdlA COG1181
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ...
 97-183 2.51e-06

D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440794 [Multi-domain]  Cd Length: 303  Bit Score: 48.95  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356004211  97 SMEKHSAYCAMLRLGLKVPKTVLVPYKNPVDnvrwaytsskynkgfdLEAIAADLGYPLYMKPFDGGGWRGVSRINNADD 176
Cdd:COG1181    93 AMDKALTKRVLAAAGLPTPPYVVLRRGELAD----------------LEAIEEELGLPLFVKPAREGSSVGVSKVKNAEE 156


                  ....*..
gi 1356004211 177 LRRAYDA 183
Cdd:COG1181   157 LAAALEE 163
PRK07178 PRK07178
acetyl-CoA carboxylase biotin carboxylase subunit;
146-182 1.37e-04

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 180865 [Multi-domain]  Cd Length: 472  Bit Score: 43.94  E-value: 1.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1356004211 146 AIAADLGYPLYMKPFDGGGWRGVSRINNADDLRRAYD 182
Cdd:PRK07178  145 AEAERIGYPVMLKATSGGGGRGIRRCNSREELEQNFP 181
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 143-183 1.50e-04

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 43.97  E-value: 1.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1356004211  143 DLEAIAADLGYPLYMKPFDGGGWRGVSRINNADDLRRAYDA 183
Cdd:PRK12999   147 EALEFAEEIGYPIMLKASAGGGGRGMRIVRSEEELEEAFER 187
PccA COG4770
Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism];
106-183 2.61e-04

Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism];


Pssm-ID: 443802 [Multi-domain]  Cd Length: 466  Bit Score: 43.08  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356004211 106 AMLRLGLK-----------VPktvLVP-YKNPVDNVRwaytsskynkgfDLEAIAADLGYPLYMKPFDGGGWRGVSRINN 173
Cdd:COG4770   109 AIRAMGDKiaakklmkaagVP---VVPgSDGPVQDAE------------EALAIAEEIGYPVLIKASAGGGGKGMRVVRS 173

                          90
                  ....*....|
gi 1356004211 174 ADDLRRAYDA 183
Cdd:COG4770   174 EEELEEAFES 183
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 143-183 2.76e-04

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 43.22  E-value: 2.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1356004211 143 DLEAIAADLGYPLYMKPFDGGGWRGVS-RINNADDLRRAYDA 183
Cdd:PRK14016  240 DAWEAAEEIGYPVVVKPLDGNHGRGVTvNITTREEIEAAYAV 281
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 143-183 2.96e-04

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 43.14  E-value: 2.96e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1356004211  143 DLEAIAADLGYPLYMKPFDGGGWRGVSRINNADDLRRAYDA 183
Cdd:COG1038    146 EALAFAEEIGYPVMLKAAAGGGGRGMRVVRSEEELEEAFES 186
PRK12767 PRK12767
carbamoyl phosphate synthase-like protein; Provisional
 97-198 3.36e-04

carbamoyl phosphate synthase-like protein; Provisional


Pssm-ID: 237195 [Multi-domain]  Cd Length: 326  Bit Score: 42.18  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356004211  97 SMEKHSAYCAMLRLGLKVPKTVLVPYKNpvdnvrwaytsskynkGFDLEAIAADLGYPLYMKPFDGGGWRGVSRINNADD 176
Cdd:PRK12767  109 CNDKWLTYEFLKENGIPTPKSYLPESLE----------------DFKAALAKGELQFPLFVKPRDGSASIGVFKVNDKEE 172

                          90       100
                  ....*....|....*....|..
gi 1356004211 177 LRRAYDASGEMLmhLQATVDYE 198
Cdd:PRK12767  173 LEFLLEYVPNLI--IQEFIEGQ 192
PRK12833 PRK12833
acetyl-CoA carboxylase biotin carboxylase subunit; Provisional
 142-179 3.44e-04

acetyl-CoA carboxylase biotin carboxylase subunit; Provisional


Pssm-ID: 183781 [Multi-domain]  Cd Length: 467  Bit Score: 42.82  E-value: 3.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1356004211 142 FDLEA---IAADLGYPLYMKPFDGGGWRGVSRINNADDLRR 179
Cdd:PRK12833  142 ASLDAaleVAARIGYPLMIKAAAGGGGRGIRVAHDAAQLAA 182
ATP-grasp_4 pfam13535
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ...
 151-183 2.26e-03

ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.


Pssm-ID: 316093 [Multi-domain]  Cd Length: 160  Bit Score: 38.42  E-value: 2.26e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1356004211 151 LGYPLYMKPFDGGGWRGVSRINNADDLRRAYDA 183
Cdd:pfam13535   1 IPYPCVIKPSVGFFSVGVYKINNREEWKAAFAA 33
PRK06111 PRK06111
acetyl-CoA carboxylase biotin carboxylase subunit; Validated
 146-186 2.51e-03

acetyl-CoA carboxylase biotin carboxylase subunit; Validated


Pssm-ID: 180406 [Multi-domain]  Cd Length: 450  Bit Score: 40.01  E-value: 2.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1356004211 146 AIAADLGYPLYMKPFDGGGWRGVSRINNADDLRRAYDASGE 186
Cdd:PRK06111  146 AIARQIGYPVMLKASAGGGGIGMQLVETEQELTKAFESNKK 186
PRK08591 PRK08591
acetyl-CoA carboxylase biotin carboxylase subunit; Validated
 91-186 5.13e-03

acetyl-CoA carboxylase biotin carboxylase subunit; Validated


Pssm-ID: 236307 [Multi-domain]  Cd Length: 451  Bit Score: 39.01  E-value: 5.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1356004211  91 SPFTFQSM-EKHSAYCAMLRLGlkVPktvLVP-YKNPVDNVRWAYtsskynkgfdleAIAADLGYPLYMKPFDGGGWRGV 168
Cdd:PRK08591  106 SAETIRLMgDKVTAKATMKKAG--VP---VVPgSDGPVDDEEEAL------------AIAKEIGYPVIIKATAGGGGRGM 168

                          90
                  ....*....|....*....
gi 1356004211 169 SRINNADDLRRAYD-ASGE 186
Cdd:PRK08591  169 RVVRTEAELEKAFSmARAE 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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