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Conserved domains on  [gi|1351573399|ref|XP_024071082|]
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olfactory receptor 10A4-like [Terrapene triunguis]

Protein Classification

olfactory receptor( domain architecture ID 11607024)

olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 10, subfamily A olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 25-301 0e+00

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320353  Cd Length: 277  Bit Score: 518.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15225     1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15225    81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15225   161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15225   241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
 
Name Accession Description Interval E-value
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 25-301 0e+00

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 518.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15225     1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15225    81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15225   161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15225   241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 31-305 1.09e-52

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 174.23  E-value: 1.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  31 FLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTA 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 111 ECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELACA 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 191 DTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTA--SSTYFRPKSSYSP 268
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMigLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 269 DTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRRTL 305
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
 25-301 0e+00

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 518.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15225     1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15225    81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15225   161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15225   241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 25-294 4.41e-154

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 431.91  E-value: 4.41e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd13954     1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd13954    81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd13954   161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd13954   241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
 25-294 6.17e-143

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 403.79  E-value: 6.17e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15911     1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15911    81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15911   161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15911   241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
 25-294 4.04e-140

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 396.49  E-value: 4.04e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15230     1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15230    81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15230   161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15230   241 SYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
 27-301 4.68e-137

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 388.93  E-value: 4.68e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15231     3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15231    83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15231   163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15231   243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
 25-294 1.65e-134

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 382.22  E-value: 1.65e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15912     1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15912    81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15912   161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15912   241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
 28-294 1.71e-133

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 379.88  E-value: 1.71e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  28 FLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFF 107
Cdd:cd15227     4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 108 GTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLEL 187
Cdd:cd15227    84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 188 ACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSYS 267
Cdd:cd15227   164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                         250       260
                  ....*....|....*....|....*..
gi 1351573399 268 PDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15227   244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
 11-305 2.47e-133

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 380.56  E-value: 2.47e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  11 EFILVGFSNHPNLQVPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENK 90
Cdd:cd15943     1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  91 IISFAGCASQLYFFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCG 170
Cdd:cd15943    81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 171 PNQINHFFCDAPPMLELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTL 250
Cdd:cd15943   161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1351573399 251 FYGTASSTYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRRTL 305
Cdd:cd15943   241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
 26-294 2.23e-132

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 377.00  E-value: 2.23e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  26 PLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFF 105
Cdd:cd15237     2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 106 FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPML 185
Cdd:cd15237    82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 186 ELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSS 265
Cdd:cd15237   162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241

                         250       260
                  ....*....|....*....|....*....
gi 1351573399 266 YSPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15237   242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
 24-301 8.88e-132

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 375.79  E-value: 8.88e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  24 QVPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYF 103
Cdd:cd15235     1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 104 FFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPP 183
Cdd:cd15235    81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 184 MLELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPK 263
Cdd:cd15235   161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1351573399 264 SSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15235   241 SSYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
 25-301 1.66e-131

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 375.01  E-value: 1.66e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15229     1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15229    81 FFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15229   161 LPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15229   241 ASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
 27-301 5.69e-130

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 371.11  E-value: 5.69e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15421     3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15421    83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15421   163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15421   243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
 12-298 2.73e-128

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 367.42  E-value: 2.73e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  12 FILVGFSNHPNLQVPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKI 91
Cdd:cd15408     1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  92 ISFAGCASQLYFFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGP 171
Cdd:cd15408    81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 172 NQINHFFCDAPPMLELACADTFLFEIeALTATVLF-VMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTL 250
Cdd:cd15408   161 NVINHFFCDGPPLLALSCSDTSLNEM-LLFAFVGFnVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1351573399 251 FYGTASSTYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVK 298
Cdd:cd15408   240 FYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
 12-305 3.15e-126

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 362.36  E-value: 3.15e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  12 FILVGFSNHPNLQVPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKI 91
Cdd:cd15410     1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  92 ISFAGCASQLYFFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGP 171
Cdd:cd15410    81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 172 NQINHFFCDAPPMLELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLF 251
Cdd:cd15410   161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1351573399 252 YGTASSTYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRRTL 305
Cdd:cd15410   241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
 25-294 4.88e-125

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 358.46  E-value: 4.88e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15431     1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMwIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15431    81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVL-TMPLHFCGPNVINHFFCEVQAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15431   160 LKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQS 239

                         250       260       270
                  ....*....|....*....|....*....|
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15431   240 KSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
 25-303 1.01e-124

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 358.11  E-value: 1.01e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15417     1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15417    81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15417   161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRR 303
Cdd:cd15417   241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
 25-303 7.30e-124

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 355.85  E-value: 7.30e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15419     1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15419    81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15419   161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRR 303
Cdd:cd15419   241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
 25-303 7.41e-124

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 355.86  E-value: 7.41e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15411     1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15411    81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15411   161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRR 303
Cdd:cd15411   241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
 26-294 1.68e-121

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 349.23  E-value: 1.68e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  26 PLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFF 105
Cdd:cd15947     2 PLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 106 FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPML 185
Cdd:cd15947    82 WLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 186 ELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSS 265
Cdd:cd15947   162 KLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSS 241

                         250       260
                  ....*....|....*....|....*....
gi 1351573399 266 YSPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15947   242 YSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
 27-294 6.29e-121

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 348.06  E-value: 6.29e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15918     3 LFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15918    83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15918   163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242

                         250       260
                  ....*....|....*....|....*...
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15918   243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
 25-303 5.17e-120

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 345.89  E-value: 5.17e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15416     1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15416    81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15416   161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRR 303
Cdd:cd15416   241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
 27-301 3.30e-118

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 341.23  E-value: 3.30e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15420     3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15420    83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15420   163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15420   243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
 27-301 4.36e-117

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 338.61  E-value: 4.36e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15429     3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15429    83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15429   163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15429   243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
 12-303 3.04e-116

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 337.10  E-value: 3.04e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  12 FILVGFSNHPNLQVPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKI 91
Cdd:cd15945     1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  92 ISFAGCASQLYFFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGP 171
Cdd:cd15945    81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 172 NQINHFFCDAPPMLELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLF 251
Cdd:cd15945   161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1351573399 252 YGTASSTYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRR 303
Cdd:cd15945   241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
 25-294 6.07e-116

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 335.38  E-value: 6.07e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15232     1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15232    81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15232   161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15232   241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
 27-294 1.53e-115

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 334.25  E-value: 1.53e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15224     3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15224    83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15224   163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242

                         250       260
                  ....*....|....*....|....*...
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15224   243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
 25-303 6.77e-115

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 333.22  E-value: 6.77e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15409     1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15409    81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15409   161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRR 303
Cdd:cd15409   241 LYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
 25-303 2.29e-114

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 331.59  E-value: 2.29e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15413     1 IPLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15413    81 LTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15413   161 LALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRR 303
Cdd:cd15413   241 SHSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
 27-294 1.15e-112

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 327.02  E-value: 1.15e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15430     3 LFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15430    83 MGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15430   163 LACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKN 242

                         250       260
                  ....*....|....*....|....*...
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15430   243 AQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
 16-305 8.27e-111

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 323.17  E-value: 8.27e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  16 GFSNHPNLQVPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFA 95
Cdd:cd15406     1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  96 GCASQLYFFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQIN 175
Cdd:cd15406    81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 176 HFFCDAPPMLELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTA 255
Cdd:cd15406   161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1351573399 256 SSTYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRRTL 305
Cdd:cd15406   241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
 25-301 4.82e-110

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 320.58  E-value: 4.82e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15432     1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15432    81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15432   161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15432   241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
 25-308 7.56e-110

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 320.53  E-value: 7.56e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15414     1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15414    81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIealtatVLFVM------FPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASST 258
Cdd:cd15414   161 LSLSCADTQINKW------VLFIMagalgvLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFI 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1351573399 259 YFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRRTLGRK 308
Cdd:cd15414   235 YVRPSSSSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRRK 284
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
 26-301 1.59e-109

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 319.14  E-value: 1.59e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  26 PLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFF 105
Cdd:cd15234     2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 106 FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPML 185
Cdd:cd15234    82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 186 ELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSS 265
Cdd:cd15234   162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1351573399 266 YSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15234   242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
 27-301 2.38e-109

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 318.99  E-value: 2.38e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15424     3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15424    83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15424   163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15424   243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
 27-294 4.88e-108

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 315.46  E-value: 4.88e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15914     3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15914    83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15914   163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242

                         250       260
                  ....*....|....*....|....*...
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15914   243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
 25-303 1.17e-107

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 314.74  E-value: 1.17e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15415     1 VPLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15415    81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15415   161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRR 303
Cdd:cd15415   241 QYSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
 27-301 1.30e-107

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 314.42  E-value: 1.30e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15428     3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15428    83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15428   163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15428   243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
 27-301 6.87e-107

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 312.78  E-value: 6.87e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15434     3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15434    83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15434   163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15434   243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
 25-303 6.79e-106

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 310.10  E-value: 6.79e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15412     1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15412    81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15412   161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRR 303
Cdd:cd15412   241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
 27-294 8.64e-106

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 309.62  E-value: 8.64e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15915     3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15915    83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMP-SEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSS 265
Cdd:cd15915   163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242

                         250       260
                  ....*....|....*....|....*....
gi 1351573399 266 YSPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15915   243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
 27-294 1.18e-105

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 309.14  E-value: 1.18e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15939     3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15939    83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMrIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15939   163 LACTDTYVIGLLVVANSGLICLLSFLILLISYI-VILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                         250       260
                  ....*....|....*....|....*...
gi 1351573399 267 SPDtkKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15939   242 PID--KVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
 27-301 7.37e-105

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 307.44  E-value: 7.37e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15228     3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15228    83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15228   163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSP 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 267 SPDTkkLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15228   243 VLVT--PVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
 12-303 2.38e-103

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 304.40  E-value: 2.38e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  12 FILVGFSNHPNLQVPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKI 91
Cdd:cd15944     1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  92 ISFAGCASQLYFFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGP 171
Cdd:cd15944    81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 172 NQINHFFCDAPPMLELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLF 251
Cdd:cd15944   161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1351573399 252 YGTASSTYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRR 303
Cdd:cd15944   241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKK 292
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
 25-303 2.81e-100

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 295.87  E-value: 2.81e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15407     1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15407    81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15407   161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRR 303
Cdd:cd15407   241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
 24-304 3.05e-99

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 293.23  E-value: 3.05e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  24 QVPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYF 103
Cdd:cd15418     1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 104 FFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPP 183
Cdd:cd15418    81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 184 MLELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPK 263
Cdd:cd15418   161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1351573399 264 SSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRRT 304
Cdd:cd15418   241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
 27-294 3.19e-98

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 290.26  E-value: 3.19e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15226     3 LFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15226    83 FGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTIlRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15226   163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                         250       260
                  ....*....|....*....|....*...
gi 1351573399 267 SPDtkKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15226   242 PVD--KFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
 26-301 4.23e-98

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 290.12  E-value: 4.23e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  26 PLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLL-VENKIISFAGCASQLYFF 104
Cdd:cd15916     2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15916    82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15916   162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 265 SYSPDtkKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15916   242 KEALD--GVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
 27-294 7.94e-97

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 286.90  E-value: 7.94e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15913     3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15913    83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15913   163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN 242

                         250       260
                  ....*....|....*....|....*...
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15913   243 STGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
 27-294 1.16e-96

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 286.26  E-value: 1.16e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15940     3 FFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15940    83 FACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMpSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15940   163 LACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSF 241

                         250       260
                  ....*....|....*....|....*...
gi 1351573399 267 SPDtkKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15940   242 SED--KVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
 26-294 1.37e-96

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 286.15  E-value: 1.37e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  26 PLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFF 105
Cdd:cd15936     2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 106 FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPML 185
Cdd:cd15936    82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 186 ELACADTFLFEIEALTATVLFVMFPFLLILVSYMrIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSS 265
Cdd:cd15936   162 KLACTDTFLLELLMVSNSGLVTLLIFFILLISYT-VILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQT 240

                         250       260
                  ....*....|....*....|....*....
gi 1351573399 266 YSPDtkKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15936   241 FPMD--KAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
 25-301 1.60e-94

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 281.24  E-value: 1.60e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15942     1 APLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15942    81 HFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15942   161 LKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 265 SYSPDtkKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15942   241 QDPLD--GVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
 25-301 4.36e-94

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 280.07  E-value: 4.36e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15405     1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15405    81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15405   161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15405   241 VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
 27-301 4.64e-94

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 280.14  E-value: 4.64e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15433     3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15433    83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15433   163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15433   243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
 28-301 9.29e-92

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 274.34  E-value: 9.29e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  28 FLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFF 107
Cdd:cd15236     4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 108 GTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLEL 187
Cdd:cd15236    84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 188 ACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSYS 267
Cdd:cd15236   164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1351573399 268 PDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15236   244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
 27-294 6.16e-91

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 271.66  E-value: 6.16e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15946     3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15946    83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15946   163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242

                         250       260
                  ....*....|....*....|....*...
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15946   243 SPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
 27-301 3.04e-90

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 270.51  E-value: 3.04e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15233     3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15233    83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15233   163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15233   243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
 27-301 8.58e-88

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 264.02  E-value: 8.58e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHS-PMYFFLRNLASLEIGFTLVIVPKMLVNLLVEN-KIISFAGCASQLYFF 104
Cdd:cd15941     3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15941    83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15941   163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 265 SYSPDtkKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15941   243 SQAGA--GAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
 25-294 3.12e-84

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 254.80  E-value: 3.12e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15938     1 ALLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15938    81 HFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTIlrmPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKS 264
Cdd:cd15938   161 IKLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTI---RSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFS 237

                         250       260       270
                  ....*....|....*....|....*....|
gi 1351573399 265 SYSPDtkKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15938   238 TFPVD--KHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
 27-294 2.28e-82

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 250.07  E-value: 2.28e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSL-HSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFF 105
Cdd:cd15935     3 LFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 106 FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPML 185
Cdd:cd15935    83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 186 ELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTiLRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSS 265
Cdd:cd15935   163 KLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                         250       260
                  ....*....|....*....|....*....
gi 1351573399 266 YSPDtkKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15935   242 SSVD--KVASVFYTLITPALNPLIYTLRN 268
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
 27-294 3.24e-80

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 244.26  E-value: 3.24e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15937     3 LFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15937    83 LGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTiLRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSY 266
Cdd:cd15937   163 LACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                         250       260
                  ....*....|....*....|....*...
gi 1351573399 267 SPDtkKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd15937   242 PMD--KVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
 27-301 1.10e-75

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 233.34  E-value: 1.10e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15223     3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15223    83 FTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYF--RPKS 264
Cdd:cd15223   163 LACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFGK 242

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15223   243 TIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
 31-297 6.89e-64

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 203.03  E-value: 6.89e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  31 FLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTA 110
Cdd:cd15950     7 FCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 111 ECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELACA 190
Cdd:cd15950    87 ESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 191 DTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFY--GTASSTYFRPKSSYSP 268
Cdd:cd15950   167 DPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYipGLLSIYTQRFGQGVPP 246

                         250       260
                  ....*....|....*....|....*....
gi 1351573399 269 DTKKLISLSYTVITPMLNPIIYSLRNKEV 297
Cdd:cd15950   247 HTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
 31-297 3.92e-63

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 200.98  E-value: 3.92e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  31 FLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTA 110
Cdd:cd15917     7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 111 ECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELACA 190
Cdd:cd15917    87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 191 DTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFY--GTASSTYFRPKSSYSP 268
Cdd:cd15917   167 DTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYtpALFSFLTHRFGHHVPP 246

                         250       260
                  ....*....|....*....|....*....
gi 1351573399 269 DTKKLISLSYTVITPMLNPIIYSLRNKEV 297
Cdd:cd15917   247 HVHILLANLYLLLPPMLNPIVYGVRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
 31-297 4.54e-62

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 198.28  E-value: 4.54e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  31 FLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTA 110
Cdd:cd15221     7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 111 ECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELACA 190
Cdd:cd15221    87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 191 DTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYF--RPKSSYSP 268
Cdd:cd15221   167 DITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLthRFGRHIPR 246

                         250       260
                  ....*....|....*....|....*....
gi 1351573399 269 DTKKLISLSYTVITPMLNPIIYSLRNKEV 297
Cdd:cd15221   247 HVHILLANLYVLVPPMLNPIVYGVKTKQI 275
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
 27-297 7.57e-62

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 197.72  E-value: 7.57e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15222     3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15222    83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGT--ASSTYFRPKS 264
Cdd:cd15222   163 LACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPmiGLSMVHRFGK 242

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEV 297
Cdd:cd15222   243 HASPLVHVLMANVYLLVPPVLNPIIYSVKTKQI 275
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
 29-297 5.31e-57

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 185.24  E-value: 5.31e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFG 108
Cdd:cd15951     5 IPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 109 TAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELA 188
Cdd:cd15951    85 TMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 189 CADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTA--SSTYFRPKSSY 266
Cdd:cd15951   165 CADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPAlfSFLTHRFGHNV 244

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1351573399 267 SPDTKKLISLSYTVITPMLNPIIYSLRNKEV 297
Cdd:cd15951   245 PPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
 31-297 1.05e-56

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 184.51  E-value: 1.05e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  31 FLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTA 110
Cdd:cd15952     7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 111 ECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELACA 190
Cdd:cd15952    87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 191 DTFLfEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPKSSYSPDT 270
Cdd:cd15952   167 SIRI-NIIYGLFAISVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPR 245

                         250       260
                  ....*....|....*....|....*....
gi 1351573399 271 KKLISLS--YTVITPMLNPIIYSLRNKEV 297
Cdd:cd15952   246 YIHILLAnlYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
 31-297 4.25e-56

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 182.85  E-value: 4.25e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  31 FLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTA 110
Cdd:cd15953     7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 111 ECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELACA 190
Cdd:cd15953    87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 191 DTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTA--SSTYFRPKSSYSP 268
Cdd:cd15953   167 DTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPAlfSFLTHRFGQGIAP 246

                         250       260
                  ....*....|....*....|....*....
gi 1351573399 269 DTKKLISLSYTVITPMLNPIIYSLRNKEV 297
Cdd:cd15953   247 HIHIILANLYLLVPPMLNPIIYGVKTKEI 275
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
 31-305 1.09e-52

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 174.23  E-value: 1.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  31 FLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTA 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 111 ECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELACA 190
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 191 DTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTA--SSTYFRPKSSYSP 268
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMigLSMVHRFGHNVPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 269 DTKKLISLSYTVITPMLNPIIYSLRNKEVKGALRRTL 305
Cdd:pfam13853 241 LLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
 20-298 6.11e-51

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 169.70  E-value: 6.11e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  20 HPNLQVPlfliFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCAS 99
Cdd:cd15948     1 HPWISIP----FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 100 QLYFFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFC 179
Cdd:cd15948    77 QMFFLHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYC 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 180 DAPPMLELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTA--SS 257
Cdd:cd15948   157 EHMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVvlSS 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1351573399 258 TYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVK 298
Cdd:cd15948   237 TMHRFARHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
 27-297 7.50e-48

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 161.57  E-value: 7.50e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15956     3 LSLPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd15956    83 FSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYF--RPKS 264
Cdd:cd15956   163 LACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhRFGH 242

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEV 297
Cdd:cd15956   243 SVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
 10-298 6.36e-46

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 157.25  E-value: 6.36e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  10 SEFILVGFSNHPNLQVPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVEN 89
Cdd:cd15949     2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  90 KIISFAGCASQLYFFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFC 169
Cdd:cd15949    82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 170 GPNQINHFFCDAPPMLELACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVT 249
Cdd:cd15949   162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIL 241

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1351573399 250 LFYG--TASSTYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVK 298
Cdd:cd15949   242 AFYVpiAVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
 41-290 2.98e-44

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 151.68  E-value: 2.98e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  41 GNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLV-NLLVENKIISFAGCASQLYFFFFFGTAECCLLTAMA 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVyYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 120 YDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPnqiNHFFCDAPPMLELACADTFLFeiea 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSKPVSYTL---- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 200 LTATVLFVmFPFLLILVSYMRIITTILRMPSEEGR-------RKAFSTCSSHLVVVTLFYGTASSTYFRPKSSYSPDTKK 272
Cdd:pfam00001 154 LISVLGFL-LPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232

                         250       260
                  ....*....|....*....|....
gi 1351573399 273 LISLSYTVI------TPMLNPIIY 290
Cdd:pfam00001 233 LLDKALSVTlwlayvNSCLNPIIY 256
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
 31-297 7.93e-43

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 148.76  E-value: 7.93e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  31 FLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTA 110
Cdd:cd15955     7 FCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAF 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 111 ECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLA-GVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELAC 189
Cdd:cd15955    87 ESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGvLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 190 ADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYF--RPKSSYS 267
Cdd:cd15955   167 DDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFahRFGHHVA 246

                         250       260       270
                  ....*....|....*....|....*....|
gi 1351573399 268 PDTKKLISLSYTVITPMLNPIIYSLRNKEV 297
Cdd:cd15955   247 PYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
 31-297 1.01e-41

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 145.74  E-value: 1.01e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  31 FLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTA 110
Cdd:cd15954     7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 111 ECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELACA 190
Cdd:cd15954    87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 191 DTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLFYGTASSTYFRPK---SSYS 267
Cdd:cd15954   167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRfggHHIT 246

                         250       260       270
                  ....*....|....*....|....*....|
gi 1351573399 268 PDTKKLISLSYTVITPMLNPIIYSLRNKEV 297
Cdd:cd15954   247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
 27-294 1.37e-23

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 97.36  E-value: 1.37e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd00637     1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLe 186
Cdd:cd00637    81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 lacadtflfeIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEG--------------RRKAFSTCSSHLVVVTLFY 252
Cdd:cd00637   160 ----------AYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRssssnssrrrrrrrERKVTKTLLIVVVVFLLCW 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1351573399 253 G----TASSTYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRN 294
Cdd:cd00637   230 LpyfiLLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 27-301 2.92e-21

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 90.70  E-value: 2.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVytITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd14967     4 VFLSLIIL--VTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMN-RRACFQLAGVswfsgfpvatvqmmWIFSLPFCGPNQINHFFCDAPPML 185
Cdd:cd14967    82 CCTASILNLCAISLDRYLAITRPLRYRQLMTkKRALIMIAAV--------------WVYSLLISLPPLVGWRDETQPSVV 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 186 ELACaDTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRmpseegRRKAFSTCSshLVVVTL------FYGTASSTY 259
Cdd:cd14967   148 DCEC-EFTPNKIYVLVSSVISFFIPLLIMIVLYARIFRVARR------ELKAAKTLA--IIVGAFllcwlpFFIIYLVSA 218

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1351573399 260 FRPKSSYSPDTKKLIS-LSYtvITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd14967   219 FCPPDCVPPILYAVFFwLGY--LNSALNPIIYALFNRDFRRAF 259
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
 41-301 1.23e-13

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 69.98  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  41 GNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPkmLVNLLVENKIISFAGCASQLYFFFFFGTAECCLLTAMAY 120
Cdd:cd14968    17 GNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVLTQSSIFSLLAIAI 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 121 DRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHF----FCDAPPMLELAcadTFLFe 196
Cdd:cd14968    95 DRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFGWNNGAPLESGCGEGGiqclFEEVIPMDYMV---YFNF- 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 197 iealtatVLFVMFPFLLILVSYMRIITTILR-------MPSEEGRR----KAFSTCSSHLVVVTLF-------YGTASST 258
Cdd:cd14968   171 -------FACVLVPLLIMLVIYLRIFRVIRKqlrqiesLLRSRRSRstlqKEVKAAKSLAIILFLFalcwlplHIINCIT 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1351573399 259 YFRPkSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd14968   244 LFCP-ECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
 28-301 3.31e-12

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 65.69  E-value: 3.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  28 FLIFLGVytITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFF 107
Cdd:cd14969     6 YLSLIGV--LGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 108 GTAECCLLTAMAYDRYVAICNPLRYPDIMNRRAcFQLAGVSWFSGFPVATvqmmwifsLPFCGPNQInhffcdAPPMLEL 187
Cdd:cd14969    84 GLVSISTLAALAFERYLVIVRPLKAFRLSKRRA-LILIAFIWLYGLFWAL--------PPLFGWSSY------VPEGGGT 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 188 ACA-----DTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSH-----------LVVVTLF 251
Cdd:cd14969   149 SCSvdwysKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAITKRTkkaekkvakmvLVMIVAF 228

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1351573399 252 YG-----TASSTYfrpkssYSPDTKKLISLSYTVITPML-------NPIIYSLRNKEVKGAL 301
Cdd:cd14969   229 LIawtpyAVVSLY------VSFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
 25-301 4.96e-11

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 62.06  E-value: 4.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVytITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCasQLYFF 104
Cdd:cd15073     3 VAAYLIVAGI--ISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGC--QWYAF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 --FFFGTAECCLLTAMAYDRYVAICNPLRYpDIMNRRACFQLAGVSWFSGFPVAtvqmmwifSLPFCGpnqinhFFCDAP 182
Cdd:cd15073    79 lnIFFGMASIGLLTVVAVDRYLTICRPDLG-RKMTTNTYTVMILLAWTNAFFWA--------AMPLVG------WASYAL 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 183 PMLELACADTF-----LFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGR---------RKAFSTCSSHLVVV 248
Cdd:cd15073   144 DPTGATCTINWrkndsSFVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLesvnidwtdQNDVTKMSVIMIVM 223

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 249 TLFYGTASSTYFRPKSSYSPDTkklISLSYTVITPML-------NPIIYSLRNKEVKGAL 301
Cdd:cd15073   224 FLVAWSPYSIVCLWASFGEPKK---IPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
 27-295 1.48e-10

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 61.08  E-value: 1.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd14993     3 LIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQGV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFpvatvqmmwIFSLPFCGPNQINHFFCDAPPMLE 186
Cdd:cd14993    83 SVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAI---------IIMLPLLVVYELEEIISSEPGTIT 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 187 LA-CADTFLFEIE--ALTATVLFVMF--PFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSH------------LVVVT 249
Cdd:cd14993   154 IYiCTEDWPSPELrkAYNVALFVVLYvlPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRilrskkkvarmlIVVVV 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1351573399 250 LFYGT-----ASSTYFRPKSSYSPDTKKLISLSYTVITPM------LNPIIYSLRNK 295
Cdd:cd14993   234 LFALSwlpyyVLSILLDFGPLSSEESDENFLLILPFAQLLgysnsaINPIIYCFMSK 290
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
 25-228 2.41e-10

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 60.45  E-value: 2.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLvENKIISFAGCASQLYFF 104
Cdd:cd14979     1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFW-WQYPWAFGDGGCKLYYF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FF--FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVA--TVQMMWIFSLPFCGPNQI-NHFFC 179
Cdd:cd14979    80 LFeaCTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAipILFLMGIQYLNGPLPGPVpDSAVC 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1351573399 180 DAPPMLElacadTFLFEIEalTATVLFVMFPFLLILVSYMRIITTILRM 228
Cdd:cd14979   160 TLVVDRS-----TFKYVFQ--VSTFIFFVLPMFVISILYFRIGVKLRSM 201
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
 25-221 1.58e-09

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 57.56  E-value: 1.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLAsleigftlviVPKMLVNLLV-ENKIISFAG------- 96
Cdd:cd15055     1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLA----------VADFLVGLLVmPFSMIRSIEtcwyfgd 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  97 --CASQLYFFFFFGTAECCLLTAMAYDRYVAICNPLRYP-DIMNRRACFqLAGVSWFsgFPVATVQMMWIFSLPFCGPNQ 173
Cdd:cd15055    71 tfCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPtKITIRRVKI-CICLCWF--VSALYSSVLLYDNLNQPGLIR 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1351573399 174 INHFFCDappmlelaCADTFLFeIEALTATVLFVMFPFLLILVSYMRI 221
Cdd:cd15055   148 YNSCYGE--------CVVVVNF-IWGVVDLVLTFILPCTVMIVLYMRI 186
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
 30-301 1.60e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 57.69  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLAS--LEIGFTLVIVpkmLVNLLVENKIISFAGCASQLYFFFFF 107
Cdd:cd14972     4 VAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAadLLAGIAFVFT---FLSVLLVSLTPSPATWLLRKGSLVLS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 108 GTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATvqmmwifsLPFCGPNQINhffCDAPpmlel 187
Cdd:cd14972    81 LLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGWNCVL---CDQE----- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 188 ACADTF-LFEIEALTATVLFVMFPFLLILVSYMRI--------ITTILRMPSEEGRRKAFSTCSSHLVVVTL----FYGT 254
Cdd:cd14972   145 SCSPLGpGLPKSYLVLILVFFFIALVIIVFLYVRIfwclwrhaNAIAARQEAAVPAQPSTSRKLAKTVVIVLgvflVCWL 224

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1351573399 255 ASSTYFRPKSSYSPDTKKLISLSYT----VITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd14972   225 PLLILLVLDVLCPSVCDIQAVFYYFlvlaLLNSAINPIIYAFRLKEMRRAV 275
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
 30-298 5.09e-09

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 56.32  E-value: 5.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTIT-LTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFG 108
Cdd:cd15075     5 IIMAVFSIAsVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVAFFG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 109 TAECCLLTAMAYDRYVAICNPLRYPDIMNRRAcfqLAGVSWfsgfpvatvqmMWIFSLPF-------------------C 169
Cdd:cd15075    85 IAALCTVAVIAVDRLFVVCKPLGTLTFQTRHA---LAGIAS-----------SWLWSLIWntpplfgwgsyqlegvmtsC 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 170 GPNQINHffcDAPPMLELACADTFLFEIealtatvlfvmfPFLLILVSYMRIITTI----LRMPSEEGRRKAFSTCSSHL 245
Cdd:cd15075   151 APDWYSR---DPVNVSYILCYFSFCFAI------------PFAIILVSYGYLLWTLrqvaKLGVAEGGSTAKAEVQVARM 215

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1351573399 246 VVVTLF--------YGTASSTYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVK 298
Cdd:cd15075   216 VVVMVMafllcwlpYAAFALTVVSKPDVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
 29-147 1.11e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 55.30  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKI-ISFAGCASQLYFFFFF 107
Cdd:cd15305     5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAWpLPRYLCPIWISLDVLF 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1351573399 108 GTAECCLLTAMAYDRYVAICNPLRYPDIMNR-RACFQLAGV 147
Cdd:cd15305    85 STASIMHLCAISLDRYVAIRNPIEHSRFNSRtKAMMKIAAV 125
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
 27-169 1.51e-08

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 54.89  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVytITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEigFTLVIV-PKMLVNLLVENKIISFAGCasQLYFFF 105
Cdd:cd15079     5 FIYIFLGI--VSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISD--FLMMIKmPIFIYNSFYEGWALGPLGC--QIYAFL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1351573399 106 --FFGTAECCLLTAMAYDRYVAICNPlrypdimnrracfqLAGVSWFSGFPVATVQMMWIFSLPFC 169
Cdd:cd15079    79 gsLSGIGSIWTNAAIAYDRYNVIVKP--------------LNGNPLTRGKALLLILFIWLYALPWA 130
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
 34-221 1.65e-08

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 54.59  E-value: 1.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  34 VYTIT----LTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGT 109
Cdd:cd15001     5 VYVITfvlgLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 110 AECCLLTAMAYDRYVAICNPLRYPDI-MNRRACFQLAGVsWFSGFPVATVQMMWIFSLPFCGPNQINHFFCdappmlELA 188
Cdd:cd15001    85 CSVLTLTAISIERYYVILHPMKAKSFcTIGRARKVALLI-WILSAILASPVLFGQGLVRYESENGVTVYHC------QKA 157

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1351573399 189 CADTFLFEIEALTATVLFVMFPFLLILVSYMRI 221
Cdd:cd15001   158 WPSTLYSRLYVVYLAIVIFFIPLIVMTFAYARD 190
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
 27-298 2.10e-08

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 54.43  E-value: 2.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTIT-LTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFF 105
Cdd:cd15202     2 LLIVAYSFIIVFsLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 106 FFGTAECCLLTAMAYDRYVAICNPLRyPDIMNRRACFQLAGV---SWFSGFPVATVQMMWIFslpfcgpnqINHFFCDAP 182
Cdd:cd15202    82 CSVHVSAYTLTAIAVDRYQAIMHPLK-PRISKTKAKFIIAVIwtlALAFALPHAICSKLETF---------KYSEDIVRS 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 183 PMLELACADTFLFE-IEALTATVLFVMFPFLLILVSYMRIITTIL--RMPSE-------EGRRKAFSTCSSHLVVVTLFY 252
Cdd:cd15202   152 LCLEDWPERADLFWkYYDLALFILQYFLPLLVISFAYARVGIKLWasNMPGDatteryfALRRKKKKVIKMLMVVVVLFA 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1351573399 253 --GTASSTYFRPKSSYSPDTKKLISLSYTVI------TPMLNPIIYSLRNKEVK 298
Cdd:cd15202   232 lcWLPFNIYVLLLSSKPDYLIKTINAVYFAFhwlamsSTCYNPFIYCWLNERFR 285
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
 30-240 2.41e-08

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 54.22  E-value: 2.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTIT-LTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCasQLYFFFFFG 108
Cdd:cd15096     5 VIFGLIFIVgLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWC--KIVQYLVYV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 109 TAECCL--LTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWfSGFPVATVQMMWIFSLPFCGPNQINHFFCdappmle 186
Cdd:cd15096    83 TAYASVytLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIW-IVILVANIPVLFLHGVVSYGFSSEAYSYC------- 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1351573399 187 lacadTFLfEIEALTATVLFVMF-------PFLLILVSYMRIITTILRMPSEEGRRKAFST 240
Cdd:cd15096   155 -----TFL-TEVGTAAQTFFTSFflfsyliPLTLICVLYMLMLRRLRRQKSPGGRRSAESQ 209
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
 34-155 2.46e-08

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 53.89  E-value: 2.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  34 VYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECC 113
Cdd:cd15059    10 VILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIV 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1351573399 114 LLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPV 155
Cdd:cd15059    90 NLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVI 131
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
 32-298 4.86e-08

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 53.40  E-value: 4.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  32 LGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVnlLVENKIISFAGCASQLYFFFFFGTAE 111
Cdd:cd15068     8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 112 CCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMM-WIFSLPFCGPNQinHFFCDAPPMLELACA 190
Cdd:cd15068    86 IFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLgWNNCGQPKEGKN--HSQGCGEGQVACLFE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 191 DTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILR---------MPSEEGR---RKAFSTCSSHLVVVTLF------- 251
Cdd:cd15068   164 DVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRqlkqmesqpLPGERARstlQKEVHAAKSLAIIVGLFalcwlpl 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1351573399 252 YGTASSTYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVK 298
Cdd:cd15068   244 HIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFR 290
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
 32-298 4.90e-08

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 53.40  E-value: 4.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  32 LGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLveNKIISFAGCASQLYFFFFFGTAE 111
Cdd:cd15069     8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISL--GFCTDFHSCLFLACFVLVLTQSS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 112 CCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPpmlELACAD 191
Cdd:cd15069    86 IFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMSATNNSTNPADHGTN---HSCCLI 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 192 TFLFE-IEALTATVLF-----VMFPFLLILVSYMRIITTILRM--------PSEEGRRKAFSTCSSHLVVVTLF------ 251
Cdd:cd15069   163 SCLFEnVVPMSYMVYFnffgcVLPPLLIMLVIYIKIFLVACRQlqrtelmdHSRTTLQREIHAAKSLAIIVGIFalcwlp 242

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1351573399 252 -YGTASSTYFRP-----KSSYSPDTKKLISLSYTVItpmlNPIIYSLRNKEVK 298
Cdd:cd15069   243 vHILNCITLFQPefsksKPKWAMNVAILLSHANSVV----NPIVYAYRNRDFR 291
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 25-301 1.90e-07

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 51.43  E-value: 1.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15325     1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRAcfqlagvswfsgfPVATVQMMWIFSLPFcgpnQINHFFCDAPPM 184
Cdd:cd15325    81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERR-------------GLLALLCVWVLSLVI----SIGPLFGWKEPA 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LElacaDTFLFEIEALTATVLFVMF-----PFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTL-FYGTASST 258
Cdd:cd15325   144 PE----DETICQITEEPGYALFSALgsfylPLAIILVMYCRVYVVALKFSREKKAAKTLGIVVGCFVLCWLpFFLVMPIG 219

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1351573399 259 YFRPKSSySPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15325   220 SIFPAYK-PSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
 27-150 1.96e-07

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 51.56  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVytITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCasQLYFFF- 105
Cdd:cd15083     5 IFILIIGL--IGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGC--DMYGFSg 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1351573399 106 -FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWF 150
Cdd:cd15083    81 gLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWL 126
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
 29-142 2.44e-07

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 51.09  E-value: 2.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKI-ISFAGCASQLYFFFFF 107
Cdd:cd15304     5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWpLPSKLCAVWIYLDVLF 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1351573399 108 GTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACF 142
Cdd:cd15304    85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAF 119
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
 27-301 2.79e-07

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 51.17  E-value: 2.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLT-GNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVI-VPKMLVNLLVENKIISFAGCasQLYFF 104
Cdd:cd15337     2 LIGIYIAIVGILGViGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNgFPLKTISSFNKKWIWGKVAC--ELYGF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 F--FFGTAECCLLTAMAYDRYVAICNPLRYPDIM-NRRACFQLAgvswfsgfpvatvqMMWIFSLPFCGPNqinhFFCDA 181
Cdd:cd15337    80 AggIFGFMSITTLAAISIDRYLVIAKPLEAMKKMtFKRAFIMII--------------IIWLWSLLWSIPP----FFGWG 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 182 PPMLE-LACADTFLFEIEALTaTVLFVM--------FPFLLILVSYMRIITTILR------------MPS----EEGRRK 236
Cdd:cd15337   142 RYVPEgFQTSCTFDYLSRDLN-NRLFILglfifgflCPLLIIIFCYVNIIRAVRNhekemtqtaksgMGKdtekNDARKK 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1351573399 237 AFSTCSSHLVVVTLFYGTASSTY--------FRPKSSYSPDTKKLISLsYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15337   221 AEIRIAKVAIILISLFLLSWTPYavvallgqFGPAYWITPYVSELPVM-FAKASAIYNPIIYALSHPKFRAAL 292
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
 41-298 3.00e-07

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 50.93  E-value: 3.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  41 GNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENkiISFAGCASQLYFFFFFGTAECCLLTAMAY 120
Cdd:cd15070    17 GNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVT--IHFYSCLFMSCLLVVFTHASIMSLLAIAV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 121 DRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMM-WIFSLPFCGPNQINHffcdappmlelACADTFLFEIEA 199
Cdd:cd15070    95 DRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFgWNRKPSLESVNTTPL-----------QCQFTSVMRMDY 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 200 LtatVLFVMFPFLLILVSYM--------RIITTILRMPSEEGR------RKAFSTCSSHLVVVTLFYGT-------ASST 258
Cdd:cd15070   164 M---VYFSFFTWILIPLVIMcalyvdifYIIRNKLSQNATGFRetgafyGREFKTAKSLALVLFLFAVCwlplsiiNCVV 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1351573399 259 YFRPKssySPDTKKLISLSYTVITPMLNPIIYSLRNKEVK 298
Cdd:cd15070   241 YFNPK---VPKIALYLGILLSHANSMMNPIVYACKIKKFK 277
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
 29-228 3.70e-07

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 50.71  E-value: 3.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSvDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF-- 106
Cdd:cd14978     5 YVLPVICIFGIIGNILNLVVLT-RKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPYIYpl 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 ---FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPP 183
Cdd:cd14978    84 antFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTL 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1351573399 184 MLElacADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRM 228
Cdd:cd14978   164 LRQ---NETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKS 205
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 25-251 3.70e-07

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 50.54  E-value: 3.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVytITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd14971     3 VPLFFALIFL--LGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVswfsgfpvatvqmMWIFSLPFCGPNQINHFFCDAPPM 184
Cdd:cd14971    81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGC-------------IWVVSLAVAAPVLALHRLRNYTPG 147

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1351573399 185 LELACADTF----LFEIEALTATVLFVMFPFLLILVSYMRIITTILRMP-----SEEGRRKAFSTCSSHLVVVTLF 251
Cdd:cd14971   148 NRTVCSEAWpsraHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAvrpvlSEGSRRAKRKVTRLVLVVVVLF 223
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
 25-149 5.20e-07

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 50.14  E-value: 5.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15317     1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSW 149
Cdd:cd15317    81 LLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGW 125
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
 25-296 5.36e-07

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 49.96  E-value: 5.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd14982     1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRacfqlagvswfsgFPVATVQMMWIFSLPFCGPNQINHfFCDAPPM 184
Cdd:cd14982    81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKR-------------YAVGVCAGVWILVLVASVPLLLLR-STIAKEN 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACADTFLFEIEA-----LTATVLFVMFPFLLILVSYMRIITTILRMPSEEG----RRKAFSTCSSHLVV-------- 247
Cdd:cd14982   147 NSTTCFEFLSEWLASaapivLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVflvcflpy 226

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1351573399 248 -VTLFYGTASSTYFrPKSSYSPDTK---KLISLSYTVITPMLNPIIYSLRNKE 296
Cdd:cd14982   227 hVTRILYLLVRLSF-IADCSARNSLykaYRITLCLASLNSCLDPLIYYFLSKT 278
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
 26-236 6.62e-07

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 49.75  E-value: 6.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  26 PLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFF 105
Cdd:cd15012     1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 106 FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWF----SGFPVATVQMMWIFSLPFCGPNQINHffCDA 181
Cdd:cd15012    81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLtsavYNTPYFVFSQTVEILVTQDGQEEEIC--VLD 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1351573399 182 PPMLELACADTFLFeiealtatVLFVMFPFLLILVSYMRIITTILRMPSEEGRRK 236
Cdd:cd15012   159 REMFNSKLYDTINF--------IVWYLIPLLIMTVLYSKISIVLWKSSSIEARRK 205
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
 28-251 8.18e-07

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 49.54  E-value: 8.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  28 FLIFLgvytITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLV-NLLVENKiisfagcasqlyffff 106
Cdd:cd15207     8 SLIFL----LCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVdNILTGWP---------------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCL---------------LTAMAYDRYVAICNPLRypDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGP 171
Cdd:cd15207    68 FGDVMCKLsplvqgvsvaasvftLVAIAVDRYRAVVHPTE--PKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFF 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 172 NQINHFFCD--APPMLELACADTFLFeiealtatVLFVMFPFLLILVSYMRIITTILRMPS------EEGRRKAFSTCSS 243
Cdd:cd15207   146 RGQTVHICVefWPSDEYRKAYTTSLF--------VLCYVAPLLIIAVLYVRIGYRLWFKPVpgggsaSREAQAAVSKKKV 217

                         250
                  ....*....|...
gi 1351573399 244 H-----LVVVTLF 251
Cdd:cd15207   218 RvikmlIVVVVLF 230
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
 27-221 8.52e-07

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 49.66  E-value: 8.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVY-TITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFF 105
Cdd:cd15065     1 LIGIFLSLIiVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 106 FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQmmwiFSLPFCGPNQINHFFCDAPPML 185
Cdd:cd15065    81 MCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLP----IHLGWHRLSQDEIKGLNHASNP 156

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1351573399 186 ELACADTFLFEIEALTATVLFVmFPFLLILVSYMRI 221
Cdd:cd15065   157 KPSCALDLNPTYAVVSSLISFY-IPCLVMLLIYSRL 191
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
 26-161 1.23e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 48.99  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  26 PLFLIFLG-VYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15058     1 PGLLLLLAlIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMM 161
Cdd:cd15058    81 VLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIM 137
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 30-149 1.42e-06

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 48.64  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLY------F 103
Cdd:cd15103     6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIdnvidsM 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1351573399 104 FFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSW 149
Cdd:cd15103    86 ICSSLLASICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIW 131
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
 23-221 1.53e-06

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 48.97  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  23 LQVPLFLIflgVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLvENKIISFAGCASqlY 102
Cdd:cd15394     2 LIIPLYSL---VVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAF-EPRGWVFGRFMC--Y 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 103 FFFFFGTAECCL----LTAMAYDRYVAICNPLRypdimnRRacfqlaGVSWFSGFPVATVqmmWIFSLPFCGPNQINHFF 178
Cdd:cd15394    76 FVFLMQPVTVYVsvftLTAIAVDRYYVTVYPLR------RR------ISRRTCAYIVAAI---WLLSCGLALPAAAHTYY 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1351573399 179 CDAPPmLELACADTFLFEIE----ALTATVLFV--MFPFLLILVSYMRI 221
Cdd:cd15394   141 VEFKG-LDFSICEEFWFGQEkqrlAYACSTLLItyVLPLLAISLSYLRI 188
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
 30-151 2.07e-06

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 48.35  E-value: 2.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFG- 108
Cdd:cd15352     6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMDNVFDSm 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1351573399 109 -----TAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFS 151
Cdd:cd15352    86 icislVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVV 133
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
 29-149 2.33e-06

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 48.29  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKI-ISFAGCASQLYFFFFF 107
Cdd:cd15306     5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMWpLPLVLCPIWLFLDVLF 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1351573399 108 GTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSW 149
Cdd:cd15306    85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVW 126
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
 34-166 4.21e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 47.37  E-value: 4.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  34 VYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLAsleIGFTLVIVPKMLVNLLVENKIISFAG---CASQLYFFFFFGTA 110
Cdd:cd14986    10 LFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLA---IADLVVAFFTVLTQIIWEATGEWVAGdvlCRIVKYLQVVGLFA 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1351573399 111 ECCLLTAMAYDRYVAICNPLRYPDimNRRACFQLAGVSWFSGFPVATVQMMwIFSL 166
Cdd:cd14986    87 STYILVSMSLDRYQAIVKPMSSLK--PRKRARLMIVVAWVLSFLFSIPQLV-IFVE 139
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
 34-301 4.62e-06

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 47.50  E-value: 4.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  34 VYTITLTGNVLIILVTSVDPSL--HSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAE 111
Cdd:cd14976    10 VFTVGLLGNLLVLYLLKSNKKLrqQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVTKLNMYSS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 112 CCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMmwIFSLPFCGpnQINHFFCDAP-PMLELACA 190
Cdd:cd14976    90 IFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEA--IFSTDTWS--SVNHTLCLLRfPKNSSVTR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 191 DTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLF-----------YGTA---- 255
Cdd:cd14976   166 WYNWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSKRRKSRVTKSVFIVVLSFFicwlpnqalslWSALikfd 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1351573399 256 ----SSTYFRPKSSYSPDTkklISLSYTviTPMLNPIIYSLRNKEVKGAL 301
Cdd:cd14976   246 dvpfSDAFFAFQTYAFPVA---ICLAHS--NSCLNPVLYCLVRREFRDAL 290
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 25-301 6.76e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 46.81  E-value: 6.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVP----KMLVNLLVENKIISFAGCASQ 100
Cdd:cd15326     1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPfsatLEILGYWVFGRIFCDIWAAVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 101 LyfffFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNR-RACFQLAGVswfsgfpvatvqmmWIFSL-----PFCGPNQi 174
Cdd:cd15326    81 V----LCCTASILSLCAISIDRYIGVRHSLQYPTIVTRkRAILALLGV--------------WVLSTvisigPLLGWKE- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 175 nhffcDAPPmlelacaDTFLFEIE-----ALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVT 249
Cdd:cd15326   142 -----PAPP-------DDKVCEITeepfyALFSSLGSFYIPLIVILVMYCRVYIVALKFSREKKAAKTLGIVVGMFILCW 209

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1351573399 250 LFYGTASSTYFRPKSSYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15326   210 LPFFIALPLGSLFSHLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
 41-235 6.95e-06

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 46.90  E-value: 6.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  41 GNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNL-LVENKIISFAGCasQLYFFFFFGTAECCLLTAMA 119
Cdd:cd14997    17 GNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETwAREPWLLGEFMC--KLVPFVELTVAHASVLTILA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 120 --YDRYVAICNPLRypdimnrracfqlAGVSWFSGFPVATVQMMWIFSLPFCGP-------NQINHFFCDAPPMLELAcA 190
Cdd:cd14997    95 isFERYYAICHPLQ-------------AKYVCTKRRALVIIALIWLLALLTSSPvlfitefKEEDFNDGTPVAVCRTP-A 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1351573399 191 DTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRR 235
Cdd:cd14997   161 DTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRR 205
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
 30-151 7.32e-06

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 46.47  E-value: 7.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFG- 108
Cdd:cd15354     6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIDNVFDSl 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1351573399 109 -----TAECCLLTAMAYDRYVAICNPLRYPDIMN-RRACFQLAGVSWFS 151
Cdd:cd15354    86 icisvVASMCSLLAIAVDRYVTIFYALRYHNIMTvRRAGIIIACIWTFC 134
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
 28-149 7.69e-06

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 46.77  E-value: 7.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  28 FLIFLGVyTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEI-----GFTLVIVPKMLVNLLVENKIISFAGCASQly 102
Cdd:cd15085     5 FLMFLNA-TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLmmalcGTTIVTVTNYEGYFYLGDAFCIFQGFAVN-- 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1351573399 103 fffFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACfQLAGVSW 149
Cdd:cd15085    82 ---YFGIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGY-QGLLFIW 124
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
 30-134 8.27e-06

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 46.52  E-value: 8.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLvIVPKMLVNLLVENKIISFAGCASQLYFFFFFGT 109
Cdd:cd14970     6 VYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLL-GLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMF 84

                          90       100
                  ....*....|....*....|....*
gi 1351573399 110 AECCLLTAMAYDRYVAICNPLRYPD 134
Cdd:cd14970    85 TSIFCLTVMSVDRYLAVVHPVKSLR 109
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
 32-151 9.29e-06

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 46.25  E-value: 9.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  32 LGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCasQLYFFF--FFGT 109
Cdd:cd15336     8 LIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGC--ELYAFCgaLFGI 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1351573399 110 AECCLLTAMAYDRYVAICNPLRYPDIMN-RRACFQLAGVSWFS 151
Cdd:cd15336    86 TSMITLLAISLDRYLVITKPLASIRWVSkKRAMIIILLVWLYS 128
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
 25-149 9.71e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 46.19  E-value: 9.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNllvenkiiSFAGCasqLYFF 104
Cdd:cd15312     1 VAMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVR--------SVESC---WYFG 69

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1351573399 105 FFFGTAECCL-----------LTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSW 149
Cdd:cd15312    70 DLFCKIHSSLdmmlsttsifhLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISW 125
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
 28-153 1.18e-05

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 45.95  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  28 FLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFF 107
Cdd:cd15063     4 LLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWM 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1351573399 108 GTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGF 153
Cdd:cd15063    84 CTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSF 129
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
 37-161 1.97e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 45.44  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  37 ITLTGNVLIILVTSVDPSL-HSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECCLL 115
Cdd:cd15104    12 LIITGNLLVIVALLKLIRKkDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSL 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1351573399 116 TAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMM 161
Cdd:cd15104    92 AAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLI 137
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
 27-227 2.12e-05

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 45.04  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITltGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15061     4 SFLILAIIFTIF--GNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFpvatvqmmWIFSLPFCGPNQinHFFCDappmlE 186
Cdd:cd15061    82 LCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISL--------LITSPPLVGPSW--HGRRG-----L 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1351573399 187 LACADTFLFEIEALTATVLFVMfPFLLILVSYMRIITTILR 227
Cdd:cd15061   147 GSCYYTYDKGYRIYSSMGSFFL-PLLLMLFVYLRIFRVIAK 186
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
 30-139 2.54e-05

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 44.90  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLA------SLEIGFTLVIVPKMLVNLLVEN-------KIISFAG 96
Cdd:cd15353     6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAvadmlvSVSNGSETVVITLLNGNDTDAQsftvnidNVIDSVI 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1351573399  97 CASQLyfffffgtAECCLLTAMAYDRYVAICNPLRYPDIMNRR 139
Cdd:cd15353    86 CSSLL--------ASICSLLSIAVDRYFTIFYALQYHNIMTVR 120
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
 27-300 2.61e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 45.01  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTI-TLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFF 105
Cdd:cd15064     2 LISVLLSLIILaTILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 106 FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWifslpFCGPNQInhffcdapPML 185
Cdd:cd15064    82 TCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFG-----WRTPDSE--------DPS 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 186 ELACADTFLFEIealTATVLFVMFPFLLILVSYMRIITTILRmpseegRRKAFSTCSSHLVVVTL----FYGTASSTYFR 261
Cdd:cd15064   149 ECLISQDIGYTI---FSTFGAFYIPLLLMLILYWKIYRAAAR------ERKAAKTLGIILGAFIVcwlpFFLVALIVPLC 219

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1351573399 262 PKSSYSPDTKKLIS-LSYTviTPMLNPIIYSLRNKEVKGA 300
Cdd:cd15064   220 SHCWIPLALKSFFLwLGYF--NSLINPLIYTFFNKDFRKA 257
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
 25-153 3.15e-05

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 44.57  E-value: 3.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVytITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCasQLYFF 104
Cdd:cd15074     3 IGIYLTVIGI--LSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGC--VFYGF 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1351573399 105 --FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGF 153
Cdd:cd15074    79 cgFLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALF 129
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
 37-227 3.89e-05

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 44.51  E-value: 3.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  37 ITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECCLLT 116
Cdd:cd15959    13 VIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLC 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 117 AMAYDRYVAICNPLRYPDIMNRRACFqlagvswfsgfpvATVQMMWIFSLPFCGPNQINHFFCDAPPMLELACADT---- 192
Cdd:cd15959    93 AIAVDRYLAITNPLRYEALVTKRRAR-------------TAVCLVWAISAAISFLPIMNQWWRDGADEEAQRCYDNprcc 159

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1351573399 193 -FLFEIE-ALTATVLFVMFPFLLILVSYMRIITTILR 227
Cdd:cd15959   160 dFVTNMPyAIVSSTVSFYVPLLVMIFVYVRVFVVATR 196
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
 25-132 4.82e-05

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 44.23  E-value: 4.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYtITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENK-IISFAGCASQLYF 103
Cdd:cd15052     2 WAALLLLLLVI-ATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGVwPLPLVLCLLWVTL 80

                          90       100
                  ....*....|....*....|....*....
gi 1351573399 104 FFFFGTAECCLLTAMAYDRYVAICNPLRY 132
Cdd:cd15052    81 DVLFCTASIMHLCTISLDRYMAIRYPLRT 109
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
 37-149 4.87e-05

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 44.08  E-value: 4.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  37 ITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECCLLT 116
Cdd:cd15318    13 IIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLC 92

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1351573399 117 AMAYDRYVAICNPLRYPDIMNRRACFQLAGVSW 149
Cdd:cd15318    93 FISIDRHCAICDPLLYPSKFTIRVACIFIAAGW 125
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
 37-132 5.04e-05

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 44.14  E-value: 5.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  37 ITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECCLLT 116
Cdd:cd15321    19 FTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLC 98

                          90
                  ....*....|....*.
gi 1351573399 117 AMAYDRYVAICNPLRY 132
Cdd:cd15321    99 AISLDRYWSVSRAIEY 114
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
 30-301 5.74e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 43.75  E-value: 5.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVY-TITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFG 108
Cdd:cd15327     5 VFLAIFiLMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 109 TAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGfpvatvqmMWIFSLPFCGpnqinhfFCDAPPMLELA 188
Cdd:cd15327    85 TASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSS--------MVISIGPLLG-------WKEPPPPDESI 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 189 CADTFLFEIeALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTL-FYGTASSTYFRPKSSYS 267
Cdd:cd15327   150 CSITEEPGY-ALFSSLFSFYLPLMVILVMYFRVYVVALKFSREKKAAKTLAIVVGVFILCWFpFFFVLPLGSFFPALKPS 228

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 268 PDTKKLIS-LSYtvITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15327   229 EMVFKVIFwLGY--FNSCVNPIIYPCSSKEFKRAF 261
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
 25-221 6.73e-05

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 43.75  E-value: 6.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIisFAGCASQLyFF 104
Cdd:cd15203     1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWP--FGSILCKL-VP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECC---LLTAMAYDRYVAICNPLRypDIMNRRACFQLAGVSWFSGFpvatvqmmwIFSLPFCGPNQINHFFCDA 181
Cdd:cd15203    78 SLQGVSIFVstlTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSL---------LLSLPLAIFQELSDVPIEI 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1351573399 182 PPMLELACADTFLFEI--EALTATVLFVMF--PFLLILVSYMRI 221
Cdd:cd15203   147 LPYCGYFCTESWPSSSsrLIYTISVLVLQFviPLLIISFCYFRI 190
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
 29-131 8.86e-05

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 43.14  E-value: 8.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLE-IGFTLVIVPKMLVNLLVENK-IISFAGCASQLYFFFF 106
Cdd:cd14995     5 FLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADlMVLVAAGLPNEIESLLGPDSwIYGYAGCLLITYLQYL 84

                          90       100
                  ....*....|....*....|....*
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLR 131
Cdd:cd14995    85 GINASSLSITAFTIERYIAICHPMK 109
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
 37-305 1.09e-04

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 43.03  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  37 ITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECCLLT 116
Cdd:cd17790    13 VTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 117 AMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFpvatvqMMWIFSLPFCgpnqinHFFCDAPPMLELACADTFLFE 196
Cdd:cd17790    93 IISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISF------VLWAPAILFW------QYLVGERTVLAGQCYIQFLSQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 197 --IEALTATVLFVMfPFLLILVSYMRIITTILRmpseegRRKAFSTCSSHLVVVTLFYGTASSTYFrpKSSYSPDT--KK 272
Cdd:cd17790   161 piITFGTAIAAFYL-PVTIMIILYWRIYRETIK------EKKAARTLSAILLAFILTWTPYNIMVL--VSTFCKDCvpKT 231

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 273 LISLSYTV--ITPMLNPIIYSLRNKevkgALRRTL 305
Cdd:cd17790   232 LWELGYWLcyVNSTVNPMCYALCNK----SFRDTF 262
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
 34-298 1.10e-04

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 43.23  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  34 VYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFtLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECC 113
Cdd:cd15094    10 ICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECF-LIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 114 LLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELACADTF 193
Cdd:cd15094    89 TLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSSAVNGQKAFTLY 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 194 LFEIEALTATVLFVMFPFLLIlvsyMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLF-------YGTASSTYFRPKSSY 266
Cdd:cd15094   169 TFLLGFAIPLLLISVFYTLVI----LRLRTVGPKNKSKEKRRSHRKVTRLVLTVISVYiicwlpyWAFQVHLIFLPPGTD 244

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1351573399 267 SPDTKKLISLSYTVIT---PMLNPIIYSLRNKEVK 298
Cdd:cd15094   245 MPKWEILMFLLLTVLSyanSMVNPLLYAFLSENFR 279
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
 27-222 1.13e-04

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 42.87  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLgvytITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15054     7 LCLIIL----LTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVM 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSW----FSGFPvaTVQMMWiFSLPFcGPNQINHFFCDAP 182
Cdd:cd15054    83 CCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWtlaaLASFL--PIELGW-HELGH-ERTLPNLTSGTVE 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1351573399 183 PMLELACADTFlfeieALTATVLFVMFPFLLILVSYMRII 222
Cdd:cd15054   159 GQCRLLVSLPY-----ALVASCLTFFLPSGAICFTYCRIL 193
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
 30-301 1.27e-04

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 42.66  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLG-VYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFG 108
Cdd:cd15330     5 LFLGtLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 109 TAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMM-WIFSLPFCGPNqinhffcdappmlel 187
Cdd:cd15330    85 TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLgWRTPEDRSDPD--------------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 188 ACAdtfLFEIEALTATVLFVMF--PFLLILVSYMRIITTILRmpsEEGRRKAFSTCSSHLVVVTL-FYGTASSTYFRPKS 264
Cdd:cd15330   150 ACT---ISKDPGYTIYSTFGAFyiPLILMLVLYGRIFKAAAR---ERKTVKTLGIIMGTFILCWLpFFIVALVLPFCEST 223

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1351573399 265 SYSPDTKKLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15330   224 CHMPELLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
 25-149 1.33e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 42.86  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIgFTLVIVPKMLVNLLvENKIISFAGCASQLYFF 104
Cdd:cd15928     1 AAVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLW-RYRPWRFGDLLCRLMYF 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1351573399 105 FFFGTAECCLL--TAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSW 149
Cdd:cd15928    79 FSETCTYASILhiTALSVERYLAICHPLRAKVLVTRGRVKLLIAVIW 125
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 29-251 1.43e-04

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 42.79  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSVDPSL--HSPMYFFLRNLASLEIGFTLVIVP-KMLVNLLVENKIISFAgCASQLYFFF 105
Cdd:cd15098     5 VVFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPfQATIYSLPEWVFGAFM-CKFVHYFFT 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 106 FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWF----SGFPVATVQMMwifslpFCGPNQINHFFC-- 179
Cdd:cd15098    84 VSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVlslaMASPVAVHQDL------VHHWTASNQTFCwe 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1351573399 180 DAPPMLELACADTFLFeiealtatVLFVMFPFLLILVSYMRIIT---TILRMPSEEGRRKAFSTCSSHLVVVTLF 251
Cdd:cd15098   158 NWPEKQQKPVYVVCTF--------VFGYLLPLLLITFCYAKVLNhlhKKLKNMSKKSERSKKKTAQTVLVVVVVF 224
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
 30-300 1.46e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 42.48  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTI-TLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFG 108
Cdd:cd15062     5 VALGAFILfAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 109 TAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMM-WIFSLP----FCGPNQINHFfcdapp 183
Cdd:cd15062    85 TASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLgWKEPAPadeqACGVNEEPGY------ 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 184 mlelacadtflfeieALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTL--FYGTASSTYFR 261
Cdd:cd15062   159 ---------------VLFSSLGSFYLPLAIILVMYCRVYVVAFKFSREKKAAKTLGIVVGAFVLCWFpfFVVLPLGSLFS 223

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1351573399 262 PKSSYSPDTKKLISLSYtvITPMLNPIIYSLRNKEVKGA 300
Cdd:cd15062   224 TLKPPEPVFKVVFWLGY--FNSCLNPIIYPCSSREFKRA 260
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
 31-132 1.49e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 42.62  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  31 FLGVYTITltGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTA 110
Cdd:cd15323     9 FLIVFTIV--GNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTS 86

                          90       100
                  ....*....|....*....|..
gi 1351573399 111 ECCLLTAMAYDRYVAICNPLRY 132
Cdd:cd15323    87 SIVHLCAISLDRYWSVTQAVEY 108
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
 27-300 1.63e-04

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 42.34  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYT-ITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVP-KMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15067     1 LLGVVLSLFClVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfSILHEMTGGYWLFGRDWCDVWHSFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSG----FPVAtvqMMWIFSLPFCGPNQINHFFCD 180
Cdd:cd15067    81 VLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSalisFPAI---AWWRAVDPGPSPPNQCLFTDD 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 181 AppmlelacadTFLFeieaLTATVLFVMfPFLLILVSYMRIITTILRmpseegRRKA----------FSTCSSHLVVVTL 250
Cdd:cd15067   158 S----------GYLI----FSSCVSFYI-PLVVMLFTYYRIYRAAAK------EQKAaktlgivmgvFILCWLPFFVTNI 216

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1351573399 251 FYGTASSTYFRPKSSYSPdtkKLISLSYtvITPMLNPIIYSLRNKEVKGA 300
Cdd:cd15067   217 LIGFCPSNCVSNPDILFP---LVTWLGY--INSGMNPIIYACSSRDFRRA 261
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
 38-221 1.66e-04

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 42.80  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  38 TLTGNVLIILVTSVDPSLHSPMY-FFLRNLAsleigftlviVPKMLVNLLVenkiISFAGCASQLYFFFFFG-------- 108
Cdd:cd15057    14 TLLGNALVIAAVLRFRHLRSKVTnYFIVSLA----------VSDLLVAILV----MPWAAVNEVAGYWPFGSfcdvwvsf 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 109 -----TAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMwiFSLPFCGPNQINHFFCDAPP 183
Cdd:cd15057    80 dimcsTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQ--LGWHRADDTSEALALYADPC 157

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1351573399 184 MLELAcadtfLFEIEALTATVLFVMFPFLLILVSYMRI 221
Cdd:cd15057   158 QCDSS-----LNRTYAISSSLISFYIPVAIMIVTYTRI 190
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
 23-295 1.70e-04

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 42.38  E-value: 1.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  23 LQVPLFLIflgVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLY 102
Cdd:cd15206     2 LIIPLYSV---IFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 103 FFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQinhffcdap 182
Cdd:cd15206    79 FQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGG--------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 183 pmleLACADTFLFEIEALTATVLFVMF----PFLLILVSYMRIITTILrmpseEGRRKAFSTCsshLVVVTLFYGTASST 258
Cdd:cd15206   150 ----HKCREVWPNEIAEQAWYVFLDLMllviPGLVMSVAYGLISWTLL-----EAKKRVIRML---FVIVVEFFICWTPL 217

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1351573399 259 Y-------FRPKSSYSPDTKKLISLSYTV--ITPMLNPIIYSLRNK 295
Cdd:cd15206   218 YvintwkaFDPPSAARYVSSTTISLIQLLayISSCVNPITYCFMNK 263
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
 29-168 1.77e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 42.55  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFG 108
Cdd:cd15978     5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISV 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 109 TAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPF 168
Cdd:cd15978    85 SVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPF 144
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
 29-305 1.80e-04

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 42.25  E-value: 1.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFG 108
Cdd:cd15307     5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 109 TAECCLLTAMAYDRYVAICNPLRYPDIMNRRACfqlagvswfsgfpVATVQMMWIFSLPFCGPNQINHFFCDAPPMLELA 188
Cdd:cd15307    85 TASIMHLCTISVDRYLSLRYPMRFGRNKTRRRV-------------TLKIVFVWLLSIAMSLPLSLMYSKDHASVLVNGT 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 189 CadTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVVTLF-YGTASSTYFRPKSSYS 267
Cdd:cd15307   152 C--QIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFtFVILWSPFFVLNLLPT 229

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1351573399 268 PDTKKLISLSYTVI---------TPMLNPIIYSLRNKEVKGALRRTL 305
Cdd:cd15307   230 VCAECEERISHWVFdvvtwlgyaSSMVNPIFYTIFNKVFRQAFKKVL 276
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
 25-227 1.94e-04

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 42.32  E-value: 1.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLvenkiisfagcasQLYFF 104
Cdd:cd15134     1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIW-------------QQYPW 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFfGTAECCL---------------LTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFpvatvqmmwIFSLPFC 169
Cdd:cd15134    68 VF-GEVFCKLraflsemssyasvltITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAF---------VCALPFA 137

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1351573399 170 GPNQINHFFCDAPP-----------MLELACADTFLFEIealtATVLFVMFPFLLILVSYMRIITTILR 227
Cdd:cd15134   138 IQTRIVYLEYPPTSgealeesafcaMLNEIPPITPVFQL----STFLFFIIPMIAIIVLYVLIGLQLRR 202
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
 37-150 2.00e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 42.44  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  37 ITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNL---------LVENKIISFagcasqLYFFFFF 107
Cdd:cd15005    13 VSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVrhgsgwiygALSCKVIAF------LAVLFCF 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1351573399 108 GTAecCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWF 150
Cdd:cd15005    87 HSA--FTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWT 127
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
 34-227 2.41e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 41.84  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  34 VYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLV-IVPKMLVNLLvenkiisfagcasqlyfFFFFGTAEC 112
Cdd:cd15196    10 ILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFnVLPQLIWDIT-----------------YRFYGGDLL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 113 C----------------LLTAMAYDRYVAICNPLRYPDIMNRRaCFQLAGVSWFSGFPVATVQMMwIFSLPFCGPNQINh 176
Cdd:cd15196    73 CrlvkylqvvgmyassyVLVATAIDRYIAICHPLSSHRWTSRR-VHLMVAIAWVLSLLLSIPQLF-IFSYQEVGSGVYD- 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1351573399 177 ffcdappmlelaCADTFLFE------IEALTATVLFVmfPFLLILVSYMRIITTILR 227
Cdd:cd15196   150 ------------CWATFEPPwglrayITWFTVAVFVV--PLIILAFCYGRICYVVWR 192
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 27-132 2.43e-04

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 41.99  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15208     3 LIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQTV 82

                          90       100
                  ....*....|....*....|....*.
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRY 132
Cdd:cd15208    83 SVSVSVLTLSCIALDRWYAICHPLMF 108
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
 31-221 3.07e-04

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 41.91  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  31 FLGVYTI-TLTGNVLIILVTSVDPSLHSPMY-FFLRNLASLEIGFTLVIVPKMLVNllvenKIISF----AGCASQLYFF 104
Cdd:cd15320     7 FLSVLILsTLLGNTLVCAAVIRFRHLRSKVTnFFVISLAVSDLLVAVLVMPWKAVA-----EIAGFwpfgSFCNIWVAFD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVA--TVQMMWIFSLPfCGPNQINHFFCDAP 182
Cdd:cd15320    82 IMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISfiPVQLNWHKAKP-TSFLDLNASLRDLT 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1351573399 183 pmleLACADTFLFEIEALTATVLFVMFPFLLILVSYMRI 221
Cdd:cd15320   161 ----MDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRI 195
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
 33-225 3.67e-04

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 41.65  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  33 GVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAEC 112
Cdd:cd14992     9 VIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 113 CLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLP-FCGPNQINHFFCDAPPMlelacAD 191
Cdd:cd14992    89 LTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVlFSVKNQEKIFCCQIPPV-----DN 163

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1351573399 192 TFLFEIEALTATVLFVMFPFLLILVSYMRIITTI 225
Cdd:cd14992   164 KTYEKVYFLLIFVVIFVLPLIVMTLAYARISREL 197
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
 42-301 3.67e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 41.36  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  42 NVLIILVTSVDPSLH-SPMYFFLRNLASLEIGFTLVIVPKmLVNLLVenkiisFAGCASQLYFFFFFG------TAECCL 114
Cdd:cd15341    18 NVAVLYLILSSPKLRrKPSYLFIGSLALADFLASVVFACS-FVDFHV------FHGVDSSAIFLLKLGgvtmsfTASLGS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 115 LTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWfsgfpvatVQMMWIFSLPFCGPNQINhffcdappmLELACADTF- 193
Cdd:cd15341    91 LLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMW--------VLTALIAYLPLMGWNCCP---------LNSPCSELFp 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 194 LFEIEALTATVLFVMFPFLLILVSYMRII-------TTILRMPSEEGRRKAFSTCSSHL---------VVVTLFYGTASS 257
Cdd:cd15341   154 LIPNDYLLSWLLLVAILLSGIIYTYGHVLwkahkhvVYMEKHQDQQGPGNARMRLDVRLaktlglvlaVLLICWSPVLAL 233

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1351573399 258 TYFRPKSSYSPDTKKLISLSYT--VITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15341   234 MMHSLFTSLSDHIKKAFAFCSTlcLVNSMVNPIIYALRSRELRSSL 279
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
 29-149 3.88e-04

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 41.34  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFG 108
Cdd:cd15979     5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSV 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1351573399 109 TAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSW 149
Cdd:cd15979    85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATW 125
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
 29-156 6.25e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 40.81  E-value: 6.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVEN---------KIISFAGCAS 99
Cdd:cd15392     5 LMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQywpfgefmcPVVNYLQAVS 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1351573399 100 QLYFFFffgtaeccLLTAMAYDRYVAICNPLRYPdiMNRRACFQLAGVSWFSGFPVA 156
Cdd:cd15392    85 VFVSAF--------TLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALATA 131
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
 41-301 6.54e-04

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 40.69  E-value: 6.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  41 GNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECCLLTAMAY 120
Cdd:cd15214    16 GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAI 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 121 DRYVAICNPLRYP-DIMNRRACFQLAGVswfsgfpvatvqmmWIFSLPFCGPN-------QINHFfcdappmlELACADT 192
Cdd:cd15214    96 DRYYAVLYPMVYPmKITGNRAVLALVYI--------------WLHSLIGCLPPlfgwsslEFDRF--------KWMCVAA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 193 FLFEIeALTA--TVLFVMFPFLLILVSYMRIITTilrmpSEEGRRKAFSTCsshLVVVTLFYGT-------ASSTYFRPK 263
Cdd:cd15214   154 WHKEA-GYTAfwQVWCALLPFVVMLVCYGFIFRV-----ARANQCKAFITI---LVVLGAFVTTwgpymvvISTEALWGK 224

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1351573399 264 SSYSPDTKKLIS-LSYTviTPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15214   225 NSVSPQLETLATwLSFT--SAVCHPLIYGLWNKTVRKEL 261
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
 106-151 7.44e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 40.44  E-value: 7.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1351573399 106 FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFS 151
Cdd:cd15066    81 YFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWIS 126
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
 25-300 7.82e-04

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 40.43  E-value: 7.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15213     1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAIcnpLRYPDIMNRRACFQLAGVSWFSGFPVatvqmmwifSLPFCGPNQINHFFCDAPPM 184
Cdd:cd15213    81 WFFVLEGVAILLIISVDRYLII---VQRQDKLNPHRAKILIAVSWVLSFCV---------SFPPLVGWGKYEFPPRAPQC 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LeLACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMpseegRRKAFSTCSSHLVVVT---LFYGTAS--STY 259
Cdd:cd15213   149 V-LGYTESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSF-----KTRAFTTILILFIGFSvcwLPYTVYSllSVF 222

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1351573399 260 FRPKSSYSPDTKKLISLSYtvITPMLNPIIYSLRNKEVKGA 300
Cdd:cd15213   223 SRYSSSFYVISTCLLWLSY--LKSAFNPVIYCWRIKKFREA 261
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
 37-132 8.18e-04

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 40.31  E-value: 8.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  37 ITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECCLLT 116
Cdd:cd15322    13 LTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLC 92

                          90
                  ....*....|....*.
gi 1351573399 117 AMAYDRYVAICNPLRY 132
Cdd:cd15322    93 AISLDRYWSITQAIEY 108
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
 30-149 8.41e-04

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 40.15  E-value: 8.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVivpKMLVNLLV--------------ENK---II 92
Cdd:cd15350     6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLY---KTLENILIiladmgylnrrgpfETKlddIM 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1351573399  93 SFAGCASQLYFFFFfgtaecclLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSW 149
Cdd:cd15350    83 DSLFCLSLLGSIFS--------ILAIAADRYITIFHALRYHNIMTMRRTLVILAIIW 131
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
 25-156 9.31e-04

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 40.34  E-value: 9.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLF--LIFLgvytITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLY 102
Cdd:cd15095     3 VPLIfaIIFL----VGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNY 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1351573399 103 FFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGF----PVA 156
Cdd:cd15095    79 MMQVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFllsiPVA 136
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 25-149 1.20e-03

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 39.78  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIgFTLVIVPKMLVNLLVENKIIsFAGCASQLYFF 104
Cdd:cd15132     1 IPVTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDL-LILLCLPFDLYRLWKSRPWI-FGEFLCRLYHY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1351573399 105 FFFGTAECCLL--TAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSW 149
Cdd:cd15132    79 ISEGCTYATILhiTALSIERYLAICFPLRAKVLVTRRRVKCVIAALW 125
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 30-147 1.25e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 39.78  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVE--------------NKIISFA 95
Cdd:cd15351     6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEhgvlvcrapmlqhmDNVIDTM 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1351573399  96 GCASQLyfffffgtAECCLLTAMAYDRYVAICNPLRYPDIMN-RRACFQLAGV 147
Cdd:cd15351    86 ICSSVV--------SSLSFLGAIAVDRYITIFYALRYHSIMTlQRAVNAIAGI 130
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
 29-160 1.36e-03

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 39.81  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLT--GNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15391     3 LINLYQSTIFLSvgGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLagVSWFSGFPVATVQM 160
Cdd:cd15391    83 SVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIA--SIWAISFSLSSVQL 134
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
 27-132 1.68e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 39.47  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15324     3 IVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDVL 82

                          90       100
                  ....*....|....*....|....*.
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRY 132
Cdd:cd15324    83 FCTSSIVHLCAISLDRYWSVTKAVSY 108
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
 26-219 1.79e-03

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 39.43  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  26 PLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLvENKIISFA--GCASQLYF 103
Cdd:cd15133     2 PVCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELW-QNYPFLLGsgGCYFKTFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 104 FFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVswfsgfpvatvqmMWIFSLPFCGPNQINH--FFCDA 181
Cdd:cd15133    81 FETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGC-------------VWGVSMLCALPNTSLHgiKFLGS 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1351573399 182 PPMLELACA---DTFLFEIEALTATVLFVMFPFLLILVSYM 219
Cdd:cd15133   148 GVPASAQCTvrkPQAIYNMIPQHTGHLFFVLPMAVISVLYL 188
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
 25-221 1.85e-03

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 39.15  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLAS--LEIGFtLVIVPKMLvnllvenkiISFAGCasqLY 102
Cdd:cd15314     1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVadLLVGG-LVMPPSMV---------RSVETC---WY 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 103 FFFFF----GTAECCLLTA-------MAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVAtvqmmwiFSLPFCGP 171
Cdd:cd15314    68 FGDLFckihSSFDITLCTAsilnlcfISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVG-------FGIIFLEL 140

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1351573399 172 NQINHFFcdappmLELACAD---TFLFEIEALTATVLFVMFPFLLILVSYMRI 221
Cdd:cd15314   141 NIKGIYY------NHVACEGgclVFFSKVSSVVGSVFSFYIPAVIMLCIYLKI 187
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
 34-166 2.31e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 39.01  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  34 VYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLV-IVPKMLVNLLVEnkiisFAG----CASQLYFFFFFG 108
Cdd:cd15386    10 ILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFqVLPQLIWEITYR-----FQGpdllCRAVKYLQVLSM 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1351573399 109 TAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFqLAGVSWFSGFPVATVQmMWIFSL 166
Cdd:cd15386    85 FASTYMLIMMTVDRYIAVCHPLRTLQQPSRQAYL-MIGATWLLSCILSLPQ-VFIFSL 140
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
 34-232 2.44e-03

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 39.13  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  34 VYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECC 113
Cdd:cd15123    10 IISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVF 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 114 LLTAMAYDRYVAICNPL-RYPDIMNRRACFQlAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPpmleLACADT 192
Cdd:cd15123    90 TLTVLSADRYRAIVKPLeLQTSDAVLKTCCK-AGCVWIVSMLFAIPEAVFSDLYSFRDPEKNTTFEACAP----YPVSEK 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1351573399 193 FLFEIEALTATVLFVMFPFLLILVSYMRIITTILR----MPSEE 232
Cdd:cd15123   165 ILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKstfnMPAEE 208
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 37-171 2.53e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 39.03  E-value: 2.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  37 ITLTGNVLIILVTSVDPSLHSPMYFFLRNLAsleIGFTLVIVPKMLVNLLVEnKIISFAG----CASQLYFFFFFGTAEC 112
Cdd:cd15387    13 LALTGNICVLLAIHTTRHKHSRMYFFMKHLS---IADLVVAVFQVLPQLIWD-ITFRFYGpdflCRLVKYLQVVGMFAST 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1351573399 113 CLLTAMAYDRYVAICNPLRYpdiMNRRACFQLAGVSWFSGFpVATVQMMWIFSLPFCGP 171
Cdd:cd15387    89 YMLLLMSIDRCLAICQPLRS---LHRRSDRVYVLFSWLLSL-VFSIPQVHIFSLREVGN 143
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
 25-301 2.56e-03

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 38.99  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd14988     1 VVLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAI----CNPLRYPDIMNRRACfqlAGVswfsgfpvatvqmmWIFSLPFCGPNQINHFFCD 180
Cdd:cd14988    81 FANMYSSIFFLTCLSVDRYLTLtsssPFWQQHQHRIRRALC---AGI--------------WVLSAIIPLPEVVHMQLLD 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 181 APP-----MLELACADTFLFEIeALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTCSSHLVVV------- 248
Cdd:cd14988   144 GVEpmclfLAPFETYDEWALAV-SLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRPESRRHCLLIYAYILVFVvcwlpyh 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 249 -TLFYGTASSTYFrpksSYSPDTKKLISLSYTVITPM------LNPIIYSLRNKEVKGAL 301
Cdd:cd14988   223 vTLLLLTLHGSHI----SLHCNLVHFLYFFYDVIDCFsllhcvANPILYNFLSKSFRGKL 278
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
 29-167 2.88e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 38.94  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGV-YTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFF 107
Cdd:cd15197     4 LATLWVlFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVV 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 108 GTAECCLLTAMAYDRYVAICNPLRYpdIMNRRACFQLAGVSWFSGFpvatvqmmwIFSLP 167
Cdd:cd15197    84 TYASTYVLVALSIDRYDAICHPMNF--SQSGRQARVLICVAWILSA---------LFSIP 132
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
 30-236 2.93e-03

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 38.58  E-value: 2.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGT 109
Cdd:cd15162     6 VYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNMY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 110 AECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLPFCGPNQINHFfcDAPPMLELAC 189
Cdd:cd15162    86 CSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDITTCH--DVLPEQLLVG 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1351573399 190 ADTFLFeieaLTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRK 236
Cdd:cd15162   164 DWFYYF----LSLAIVGFLIPFILTASCYVATIRTLAALEDENSEKK 206
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
 29-231 3.08e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 38.67  E-value: 3.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGN---VLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFF 105
Cdd:cd15355     5 AIYLALFVVGTVGNsitLYTLARKKSLQHLQSTVHYHLASLALSDLLILLLAMPVELYNFIWVHHPWAFGDAACRGYYFL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 106 FFGTAECCLL--TAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATvQMMWIFSLPFCGPNQINHFFCDapp 183
Cdd:cd15355    85 RDACTYATALnvASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAI-PMLFTMGEQNRSGTHPGGLICT--- 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1351573399 184 mlelACADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSE 231
Cdd:cd15355   161 ----PIVDTSTLKVVIQVNAFLSFLFPMLVISVLNTLIANQLTVMVNQ 204
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
 36-301 3.19e-03

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 38.37  E-value: 3.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  36 TITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFfffgTAECCLL 115
Cdd:cd15962    12 TVIACENAIVVAIIFYTPTLRTPMFVLIGSLATADLLAGCGLILNFVFQYVIQSETISLITVGFLVASF----TASVSSL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 116 TAMAYDRYVAICNPLRYpdimnrracfqlagvswFSGFPVATVQMM----WIFSLpFCGPNQINHFFCDAPPMlelACAD 191
Cdd:cd15962    88 LAITVDRYLSLYNALTY-----------------YSEKTVLGVHLMlaatWGVSL-CLGLLPVLGWNCLEERA---SCSI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 192 TFLFEIEALTATVLFVMFPFLLILVSYMRIITTILRMPSEEGRRKAFSTcSSHLV-------VVTLFYGTASSTYFrPKS 264
Cdd:cd15962   147 VRPLTKSNVTLLSASFFFIFILMLHLYIKICKIVCRHAHQIALQQHFLT-ASHYVatkkgvsTLAIILGTFGASWL-PFA 224

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1351573399 265 SYSPDTKKLISLSYTVIT-------PMLNPIIYSLRNKEVKGAL 301
Cdd:cd15962   225 IYCVVGDHEYPAVYTYATllpatynSMINPIIYAYRNQEIQRSM 268
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
 22-301 4.02e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 38.24  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  22 NLQVPLFLIFLgVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIgftLVIVPKMLVNLLVENKIISFAG---CA 98
Cdd:cd15082    12 NFTVLAALMFV-VTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADF---LVSLTGGTISFLTNARGYFFLGvwaCV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  99 SQLYFFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVQMMWIFSLP-----FCGPNQ 173
Cdd:cd15082    88 LEGFAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGLLFVWTFSFIWTIPPVLGWSSYTVskigtTCEPNW 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 174 INHFFCDappmlelacaDTFLfeieaLTATVLFVMFPFLLILVSYMRIITTILRMPSEEGR----RKAFSTCSSHLVVVT 249
Cdd:cd15082   168 YSGNMHD----------HTYI-----ITFFTTCFILPLGVIFVSYGKLLQKLRKVSNTQGRlgnaRKPERQVTRMVVVMI 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1351573399 250 LFYGTASSTY--FRPKSSYSPDTK-----KLISLSYTVITPMLNPIIYSLRNKEVKGAL 301
Cdd:cd15082   233 VAFMVCWTPYaaFSILVTAHPTIHldprlAAIPAFFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
 39-292 4.32e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 38.20  E-value: 4.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  39 LTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIvpKMLVNLLVENKIISFAGCASQLYFFF-----FFGTAecc 113
Cdd:cd15088    15 LVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGM--PFLIHQFAIDGQWYFGEVMCKIITALdannqFTSTY--- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 114 LLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVATVqmMWIFSLPFCGPNQINHFFCDAPPMLELacaDTF 193
Cdd:cd15088    90 ILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILP--VWVYSSLIYFPDGTTFCYVSLPSPDDL---YWF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 194 LfeieaLTATVLFVMFPFLLILVSYMRIITTILRM--PSEEG--RRKAFSTCSSHLVVVTLFYGTASSTYF--------- 260
Cdd:cd15088   165 T-----IYHFILGFAVPLVVITVCYILILHRLARGvaPGNQShgSSRTKRVTKMVILIVVVFIVCWLPFHVvqlvnlamn 239

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1351573399 261 RPKSSYSPDTKKLISLSYTviTPMLNPIIYSL 292
Cdd:cd15088   240 RPTLAFEVAYFLSICLGYA--NSCLNPFVYIL 269
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
 28-160 4.54e-03

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 38.04  E-value: 4.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  28 FLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFF 107
Cdd:cd15390     4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITT 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1351573399 108 GTAECCLLTAMAYDRYVAICNPLRYPdiMNRRACFQLAGVSWFSGFPVATVQM 160
Cdd:cd15390    84 VAASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLALPQL 134
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
 27-298 4.63e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 37.96  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTitltgNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFF 106
Cdd:cd15081    20 IFVVFASVFT-----NGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSV 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLrypdimnrracfqlAGVSWFSGFPVATVQMMWIFSLPFCGPNQI--NHFFcdaPPM 184
Cdd:cd15081    95 CGITGLWSLTIISWERWVVVCKPF--------------GNIKFDGKLAIVGIIFSWVWSAVWCAPPIFgwSRYW---PHG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 185 LELACA-DTFLFEIEALTATVLFVM------FPFLLILVSYMRIITTILRMPSE----EGRRKAFSTCSSHLVVVTLFYG 253
Cdd:cd15081   158 LKTSCGpDVFSGSSDPGVQSYMIVLmitcciIPLAIIILCYLQVWLAIRAVAQQqkesESTQKAEKEVSRMVVVMIFAYC 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1351573399 254 TASSTY--------FRPKSSYSPDTKKLISLSYTVITpMLNPIIYSLRNKEVK 298
Cdd:cd15081   238 FCWGPYtffacfaaANPGYAFHPLAAALPAYFAKSAT-IYNPIIYVFMNRQFR 289
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
 25-227 4.70e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 38.18  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  25 VPLFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFF 104
Cdd:cd15050     1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 105 FFFGTAECCLLTAMAYDRYVAICNPLRYpdiMNRRAcfqlagvswfSGFPVATVQMMWIFSLPFCGPNQINHFFCDAPP- 183
Cdd:cd15050    81 YVASTASIFSLFILCIDRYRSVQQPLKY---LKYRT----------KTRASLMISGAWLLSFLWVIPILGWHHFARGGEr 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1351573399 184 -MLELACADTFLFEI--EALTATVLFVMfPFLLILVSYMRIITTILR 227
Cdd:cd15050   148 vVLEDKCETDFHDVTwfKVLTAILNFYI-PSLLMLWFYAKIFKAVNR 193
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
 24-153 5.32e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 38.01  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  24 QVPLFLIFLGVYT-ITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLY 102
Cdd:cd15299     2 QVVLIAFLTGILAlVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1351573399 103 FFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGF 153
Cdd:cd15299    82 IDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISF 132
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
 29-156 5.70e-03

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 37.71  E-value: 5.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  29 LIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPkMLVNLLVENKIISFAGCASQLYFFF--F 106
Cdd:cd15053     5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMP-FAVYVEVNGGKWYLGPILCDIYIAMdvM 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1351573399 107 FGTAECCLLTAMAYDRYVAICNPLRYPDIMN-RRACFQLAGVsWFSGFPVA 156
Cdd:cd15053    84 CSTASIFNLCAISIDRYIAVTQPIKYARQKNsKRVLLTIAIV-WVVSAAIA 133
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
 27-252 6.07e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 37.83  E-value: 6.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  27 LFLIFLGVYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIvPKMLVNLLVENKIIsFAGCASQLYFFFF 106
Cdd:cd15968     3 LPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSL-PLLIYNYAMRDRWL-FGDFMCRLVRFLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 107 FGTAECC--LLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFsgfpVATVQMMWIFSLPFCG-PNQINHFFCDAPP 183
Cdd:cd15968    81 YFNLYGSilFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWI----LVFAQTLPILIFARTGiIRNRTVCYDLAPP 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1351573399 184 mlelacADTFLFEIEALTATVLFVMFPFLLILVSYMRIITTILR------MPSEEGRRKAFSTcsshLVVVTLFY 252
Cdd:cd15968   157 ------ALFPHYVPYGMALTVSGFLLPFSIILWCYCLVVRTLCRtlgpaePPAQARRRKSIRT----IVTVTLLF 221
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
 102-297 6.53e-03

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 37.61  E-value: 6.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 102 YFFFFFGTAECCLLTAMAYDRYVAICNPLRYPDIMN-RRACFQLAGVSWFSGFpvatvqmmwIFSLPFCGPNQINHFFCD 180
Cdd:cd14981    81 FMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKkRRARLMLGAVWAFALL---------IASLPLLGLGSYVLQYPG 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 181 APPMLELACADT------FLFEIEALTATVLFVMFPFLLIL-VSYMRIITTILRMPSEEGRRK----------------A 237
Cdd:cd14981   152 TWCFLDFYSKNTgdaayaYLYSILGLLILLVTLLCNLLVIItLLRMRRRKKRHRRSRRSARRQkrneiqmvvlllaitvV 231

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 238 FSTCSSHLVVVTLFYGTASSTyfrpkSSYSPDtkkLISLSYTVITPMLNPIIYSLRNKEV 297
Cdd:cd14981   232 FSVCWLPLMIRVLINATGDSE-----KNGKTD---LLAVRMASWNQILDPWVYILLRKEV 283
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
 30-156 8.02e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 37.54  E-value: 8.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  30 IFLGVYTITLT----GNVLIILVTSVDPSLH---SPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLY 102
Cdd:cd15356     2 LFTAVYALIWAlgaaGNALTIHLVLKKRSLRglqGTVHYHLVSLALSDLLILLISVPIELYNFVWFHYPWVFGDLVCRGY 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1351573399 103 FFF--FFGTAECCLLTAMAYDRYVAICNPLRYPDIMNRRACFQLAGVSWFSGFPVA 156
Cdd:cd15356    82 YFVrdICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFA 137
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
 37-222 8.09e-03

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 37.32  E-value: 8.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  37 ITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFTLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECCLLT 116
Cdd:cd15389    13 ISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTLTLT 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 117 AMAYDRYVAICNPLRyPDIMNRRAcfqlagvswfsgfpVATVQMMWI----FSLPFCGPNQINHFFCDApPMLELACADT 192
Cdd:cd15389    93 AIALDRHRVILHPLK-PRITPCQG--------------VVVIAIIWImascLSLPHAIYQKLVEFEYSN-ERTRSRCLPS 156

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1351573399 193 F-----LFEIE-ALTATVLFVMFPFLLILVSYMRII 222
Cdd:cd15389   157 FpepsdLFWKYlDLATFILQYVLPLLIIGVAYTRVA 192
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
 34-232 9.63e-03

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 37.16  E-value: 9.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399  34 VYTITLTGNVLIILVTSVDPSLHSPMYFFLRNLASLEIGFtLVIVPKMLVNLLVENKIISFAGCASQLYFFFFFGTAECC 113
Cdd:cd15183    10 VFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVF-LFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYSEIF 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1351573399 114 LLTAMAYDRYVAICNplrypdimnrrACFQLAGVSwfSGFPVATVQMMWIFSLPFCGPNQinHFFCDAPPMLELACADTF 193
Cdd:cd15183    89 FIILLTIDRYLAIVH-----------AVFALRART--VTFGIITSIITWALAILASMPCL--YFFKSQWEFTHHTCSAHF 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1351573399 194 LFE-------IEALTATVLFVMFPFLLILVSYMRIITTILRMPSEE 232
Cdd:cd15183   154 PRKslirwkrFQALKLNLLGLILPLLVMIICYTGIINILLRRPNEK 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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