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Conserved domains on  [gi|1347662198|gb|PPR69965|]
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Protein GrpE [Alphaproteobacteria bacterium MarineAlpha3_Bin1]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 1562)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

CATH:  3.90.20.20|2.30.22.10
Gene Ontology:  GO:0000774|GO:0051087|GO:0006457|GO:0042803
SCOP:  4003783|4002724

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE super family cl03075
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 27-236 7.22e-58

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


The actual alignment was detected with superfamily member PRK14141:

Pssm-ID: 446000  Cd Length: 209  Bit Score: 183.33  E-value: 7.22e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  27 EPDAEKLPEGEADEtAEEGAVEAESNEETSPGDVPEEVPEEeeedLEATVADLNDKLLRALAETENIRRRAVRDKEDASK 106
Cdd:PRK14141    3 DEKNKNGNPADAAR-DANNPVDREAKPYEMEDDPEPDPLEA----LKAENAELKDRMLRLAAEMENLRKRTQRDVADARA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 107 YAISNFARDMLALSDNLHRAMDSVDPETR-QKDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEM 185
Cdd:PRK14141   78 YGIAGFARDMLSVSDNLRRALDAIPAEARaAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEV 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1347662198 186 DDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSKGGAK-ETAANAEEPETVA 236
Cdd:PRK14141  158 PNPDVPNNTVVQVVQAGYTIGERVLRPAMVGVAKGGPKaAAEAGASTSEDDA 209
 
Name Accession Description Interval E-value
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 27-236 7.22e-58

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 183.33  E-value: 7.22e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  27 EPDAEKLPEGEADEtAEEGAVEAESNEETSPGDVPEEVPEEeeedLEATVADLNDKLLRALAETENIRRRAVRDKEDASK 106
Cdd:PRK14141    3 DEKNKNGNPADAAR-DANNPVDREAKPYEMEDDPEPDPLEA----LKAENAELKDRMLRLAAEMENLRKRTQRDVADARA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 107 YAISNFARDMLALSDNLHRAMDSVDPETR-QKDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEM 185
Cdd:PRK14141   78 YGIAGFARDMLSVSDNLRRALDAIPAEARaAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEV 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1347662198 186 DDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSKGGAK-ETAANAEEPETVA 236
Cdd:PRK14141  158 PNPDVPNNTVVQVVQAGYTIGERVLRPAMVGVAKGGPKaAAEAGASTSEDDA 209
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 71-220 4.18e-55

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 174.19  E-value: 4.18e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  71 DLEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMDSVDpetrqKDAAVEQIMVGLEM 150
Cdd:COG0576     3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAE-----EDEDVKSLLEGVEM 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 151 TAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSKG 220
Cdd:COG0576    78 TLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 77-217 1.04e-53

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 169.99  E-value: 1.04e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  77 ADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMDSVDpetrqKDAAVEQIMVGLEMTAREVN 156
Cdd:cd00446     1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAP-----KEEELKNLLEGVEMTLKQLL 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1347662198 157 NAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGV 217
Cdd:cd00446    76 KVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
71-219 2.30e-48

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 157.38  E-value: 2.30e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  71 DLEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMDSVdpetrQKDAAVEQIMVGLEM 150
Cdd:pfam01025  22 ELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSA-----PENEDVKSLLEGVEM 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1347662198 151 TAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:pfam01025  97 TLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMVVVSK 165
 
Name Accession Description Interval E-value
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 27-236 7.22e-58

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 183.33  E-value: 7.22e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  27 EPDAEKLPEGEADEtAEEGAVEAESNEETSPGDVPEEVPEEeeedLEATVADLNDKLLRALAETENIRRRAVRDKEDASK 106
Cdd:PRK14141    3 DEKNKNGNPADAAR-DANNPVDREAKPYEMEDDPEPDPLEA----LKAENAELKDRMLRLAAEMENLRKRTQRDVADARA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 107 YAISNFARDMLALSDNLHRAMDSVDPETR-QKDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEM 185
Cdd:PRK14141   78 YGIAGFARDMLSVSDNLRRALDAIPAEARaAADAGLKALIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEV 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1347662198 186 DDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSKGGAK-ETAANAEEPETVA 236
Cdd:PRK14141  158 PNPDVPNNTVVQVVQAGYTIGERVLRPAMVGVAKGGPKaAAEAGASTSEDDA 209
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 71-220 4.18e-55

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 174.19  E-value: 4.18e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  71 DLEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMDSVDpetrqKDAAVEQIMVGLEM 150
Cdd:COG0576     3 ELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAE-----EDEDVKSLLEGVEM 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 151 TAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSKG 220
Cdd:COG0576    78 TLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 77-217 1.04e-53

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 169.99  E-value: 1.04e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  77 ADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMDSVDpetrqKDAAVEQIMVGLEMTAREVN 156
Cdd:cd00446     1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAP-----KEEELKNLLEGVEMTLKQLL 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1347662198 157 NAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGV 217
Cdd:cd00446    76 KVLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
71-219 2.30e-48

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 157.38  E-value: 2.30e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  71 DLEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMDSVdpetrQKDAAVEQIMVGLEM 150
Cdd:pfam01025  22 ELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSA-----PENEDVKSLLEGVEM 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1347662198 151 TAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:pfam01025  97 TLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMVVVSK 165
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 23-220 6.86e-40

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 136.26  E-value: 6.86e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  23 NLDQEPDAEKLPEGEADETAEEGAVEAESNEETSPgdvpeevpEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKE 102
Cdd:PRK14139    3 NTQQNPSEQEAEEAGAAAQAAAAAAAAAEDAAPAL--------EAELAEAEAKAAELQDSFLRAKAETENVRRRAQEDVA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 103 DASKYAISNFARDMLALsdnlhraMDSVDPETRQKDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEAL 182
Cdd:PRK14139   75 KAHKFAIESFAESLLPV-------KDSLEAALADESGDLEKLREGVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAI 147

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1347662198 183 fEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSKG 220
Cdd:PRK14139  148 -SMVPAEQEPNTVVAVLQKGYTIADRVLRPALVTVAAP 184
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 53-230 1.31e-37

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 131.24  E-value: 1.31e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  53 EETSPGDVPEEVPEEEEEDLEATVAD---LNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMdS 129
Cdd:PRK14155    3 DEQTPAEDGPFEADDAAQEIEALKAEvaaLKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRAT-A 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 130 VDPETRQkDAAVEQIMVGLEMTAREVNNAFERYGIKVIE-AMGEKFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKDR 208
Cdd:PRK14155   82 ASPKDSA-DPAVKNFIIGVEMTEKELLGAFERNGLKKIDpAKGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGYELMGR 160

                         170       180
                  ....*....|....*....|..
gi 1347662198 209 LLRPAKVGVSKGGAKETAANAE 230
Cdd:PRK14155  161 LVRPAMVAVAAKGSTGPAAPAE 182
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 31-219 3.99e-37

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 129.35  E-value: 3.99e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  31 EKLPEGEADETAEEGAVEAESNEET---SPGDVPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKEDASKY 107
Cdd:PRK14140    5 NEQVEEEVEETEVEEAVEDEVEEETveeESEAELLDEEQAKIAELEAKLDELEERYLRLQADFENYKRRIQKENEAAEKY 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 108 AISNFARDMLALSDNLHRAMdSVDPETRQkdaaVEQIMVGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDD 187
Cdd:PRK14140   85 RAQSLASDLLPALDNFERAL-QIEADDEQ----TKSLLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDED 159

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1347662198 188 ASKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14140  160 EDFESNEVVEELQKGYKLKDRVIRPSMVKVNQ 191
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 37-219 2.52e-33

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 119.64  E-value: 2.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  37 EADETAEEGAVEAESNEETSPGDVPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDM 116
Cdd:PRK14150   15 EEIEAEVEQQEEADEAELEDELDEADARIAELEAQLAEAQAEERDSVLRARAEVENIRRRAEQDVEKAHKFALEKFANEL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 117 LALSDNLHRAMDSVDPEtrqkDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVV 196
Cdd:PRK14150   95 LPVIDNLERALQAADKE----NEALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQESEDHEPNTVM 170

                         170       180
                  ....*....|....*....|...
gi 1347662198 197 QVVETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14150  171 MVMQKGYTLNGRLLRPAMVMVSK 193
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 42-219 7.79e-31

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 112.56  E-value: 7.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  42 AEEGAVEAESNEETSPGDVPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSD 121
Cdd:PRK14151    2 ADEQTLDLQAPEAAQAEAAAGDDLTARVQELEEQLAAAKDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 122 NLHRAMDSVDPEtrqkDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVVQVVET 201
Cdd:PRK14151   82 SLERGLELSSAD----DEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQK 157

                         170
                  ....*....|....*...
gi 1347662198 202 GYVLKDRLLRPAKVGVSK 219
Cdd:PRK14151  158 GYLLNGRLLRPAMVVVSK 175
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 47-219 8.46e-29

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 107.37  E-value: 8.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  47 VEAESNEETSPGDVPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRA 126
Cdd:PRK14161    6 IENNEQTINDIAEEIVETANPEITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 127 MDSvdpETRQKDAAVEQIMVGLEMTAREVNNAFERYGIKVIE-AMGEKFDHNLHEALFEMDDASKPPGTVVQVVETGYVL 205
Cdd:PRK14161   86 LAH---KPANSDVEVTNIIAGVQMTKDELDKVFHKHHIEEIKpEIGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYKI 162

                         170
                  ....*....|....
gi 1347662198 206 KDRLLRPAKVGVSK 219
Cdd:PRK14161  163 RDRLLRPATVQVVK 176
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 28-219 1.70e-26

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 101.84  E-value: 1.70e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  28 PDAEKLPEGEADETAEEGAVEAESNEETSPGDVPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKEDASKY 107
Cdd:PRK14162    7 PSEKDLPQEETTDEAPKKEAKEAPKEEDQEKQNPVEDLEKEIADLKAKNKDLEDKYLRSQAEIQNMQNRYAKERAQLIKY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 108 AISNFARDMLALSDNLHRAMdsvdpETRQKDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMD- 186
Cdd:PRK14162   87 ESQSLAKDVLPAMDNLERAL-----AVKADDEAAKQLKKGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQTVAa 161

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1347662198 187 DASKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14162  162 ENDDQKDHVVQVLQKGYQYKDRTLRPAMVVVAQ 194
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 40-219 1.73e-24

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 96.30  E-value: 1.73e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  40 ETAEEGAVEAESNEETSPGDVPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLAL 119
Cdd:PRK14159    3 EQKQEFENENAENSEHLQDENLQNIEDVEQNKLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 120 SDNLHRAMDsvdpeTRQKDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAMGEkFDHNLHEALFEMDDASKPPGTVVQVV 199
Cdd:PRK14159   83 LDALEAAVN-----VECHDEISLKIKEGVQNTLDLFLKKLEKHGVALIKEEKE-FDPNLHEAMFHVDSENHQSGEVVQVL 156

                         170       180
                  ....*....|....*....|
gi 1347662198 200 ETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14159  157 QKGYKIADRVIRPTKVSVAK 176
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 26-219 7.03e-24

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 94.94  E-value: 7.03e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  26 QEPDAEKLPEGEADETAEEGAVEAESNEEtSPGDVPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKEDAS 105
Cdd:PRK14149    3 DEHNQEHDHLSQKEPESEEKACACKEQQG-EEKQEASEKEGEIKEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 106 KYAISNFARDMLALSDNLHRAMDSVdpetrQKDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAMGEkFDHNLHEALFEM 185
Cdd:PRK14149   82 EYAYEKIALDLLPVIDALLGALKSA-----AEVDKESALTKGLELTMEKLHEVLARHGIEGIECLEE-FDPNFHNAIMQV 155

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1347662198 186 DDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14149  156 KSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAK 189
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 35-225 3.76e-23

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 92.98  E-value: 3.76e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  35 EGEADETAEEGAVEAESNEETSpgDVPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFAR 114
Cdd:PRK14153   10 KAENSEARNSGSSAEEAEELKE--EPEDSTADSETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 115 DMLALSDNLHRAMDSVdpetrQKDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGT 194
Cdd:PRK14153   88 DLLEVTDNFERALESA-----RTAEDMNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETSEVPDNT 162

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1347662198 195 VVQVVETGYVLKDRLLRPAKVGVSKGGAKET 225
Cdd:PRK14153  163 IVDVCKPGYALNSKVIRPAMVSVARNPDEEE 193
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 29-219 5.54e-23

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 92.87  E-value: 5.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  29 DAEKLPEGEADETAEEGAVEAESNEETSPGDVPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKEDASKYA 108
Cdd:PRK14144   14 DEHKEEHKVENEILEEETDEESQHQEPALGHPSYTALEEQLTLAEQKAHENWEKSVRALAELENVRRRMEREVANAHKYG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 109 ISNFARDMLALSDNLHRAMDSVDpetRQKDAAVEQimvGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDDA 188
Cdd:PRK14144   94 VEKLISALLPVVDSLEQALQLAD---KNSDPSMHE---GLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQPAP 167

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1347662198 189 SKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14144  168 GAPPNSVITVFQKGYKLSDRVIRPARVIVST 198
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 31-222 1.19e-20

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 86.65  E-value: 1.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  31 EKLPEGEADE---TAEEGAVEA----ESNEETSPGDVPEEvpeeeeeDLEATVADLN----DKLLRALAETENIRRRAVR 99
Cdd:PRK10325    6 QKTPEGQAPEeiiMDQHEEIEAvepeASAEQVDPRDEKIA-------NLEAQLAEAQtrerDGILRVKAEMENLRRRTEL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 100 DKEDASKYAISNFARDMLALSDNLHRAMDSVDPETRQKDAAVEqimvGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLH 179
Cdd:PRK10325   79 DIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVE----GIELTLKSMLDVVRKFGVEVIAETNVPLDPNVH 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1347662198 180 EALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSKGGA 222
Cdd:PRK10325  155 QAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAKA 197
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 25-219 3.32e-20

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 85.57  E-value: 3.32e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  25 DQEPDAEKLPEGEADETAEEGAVEAESNEEtspgdvPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKEDA 104
Cdd:PRK14148   11 DKSLDIETAAQVETAQESASGALEELSVEE------QLERAKDTIKELEDSCDQFKDEALRAKAEMENIRKRAERDVSNA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 105 SKYAISNFARDMLALSDNLHRAMDSvdpETRQKDAAVeqIMVGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEALFE 184
Cdd:PRK14148   85 RKFGIEKFAKELLPVIDSIEQALKH---EVKLEEAIA--MKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAM 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1347662198 185 MDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14148  160 IPNPEFEDNTIFDVFQKGYMLNGRIVRAAKVVIVK 194
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 30-219 7.91e-20

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 84.21  E-value: 7.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  30 AEKLPEGEADET-AEEGAVEAESnEETSPGDVPEEVPEEEEEDLEAtvADLNDKLLRALAETENIRRRAVRDKEDASKYA 108
Cdd:PRK14158   12 AEALKAKAAKEAeAAQGKPEAAQ-PVAAADRIKELEEALAAKEAEA--AANWDKYLRERADLENYRKRVQKEKEELLKYG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 109 ISNFARDMLALSDNLHRAMDSVDPETrqkdaaVEQIMVGLEMTAREVNNAFERYGIKVIEA-MGEKFDHNLHEALFEMDD 187
Cdd:PRK14158   89 NESLILEILPAVDNMERALDHADEES------MSAIIEGIRMTLSMLLSTLKKFGVTPVEAeKGTPFDPAYHQAMCQVES 162

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1347662198 188 ASKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14158  163 AEQEPNTVVAVFQKGYLLNERLLRPAMVSVAT 194
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 21-219 1.85e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 75.56  E-value: 1.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  21 DTNLDQEPDAEKLPEGEADETAEEGAVEAESNEETSPGDVPEEVPEEEEEDLEA--------------TVADLNDKLLRA 86
Cdd:PRK14160    8 AKHENMEEDCCKENENKEEDKGKEEDLEFEEIEKEEIIEDSEESNEVKIEELKDennklkeenkklenELEALKDRLLRT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  87 LAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMDSvdpetrqkDAAVEQIMVGLEMTAREVNNAFERYGIKV 166
Cdd:PRK14160   88 VAEYDNYRKRTAKEKEGIYSDACEDVLKELLPVLDNLERAAAV--------EGSVEDLKKGIEMTVKQFKTSLEKLGVEE 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1347662198 167 IEAMGEkFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14160  160 ISTEGE-FDPNLHNAVMHVEDENYGENEIVEVFQKGYKRGDKVIRYSMVKVAN 211
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 1-233 3.12e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 75.53  E-value: 3.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198   1 MNPEDNDNEiEPGAEATKTPDTNLDQEPDAEKLPEGEADETAEEGAVEAESNEE-TSPGDVPEEVPEEEEEDLEATVA-- 77
Cdd:PRK14143    1 STPEQDPLE-VKLAVISESEAEDNSPESSEEVTEQEAELTNPEGDAAEAESSPDsGSAASETAADNAARLAQLEQELEsl 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  78 -----DLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMDSVDPETrQKDAAVEQIMVGLemtA 152
Cdd:PRK14143   80 kqeleELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQQLKPEG-EEAQALHRSYQGL---Y 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 153 REVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSKG-GAKETAANAEE 231
Cdd:PRK14143  156 KQLVDVLKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKVSMGpGPSSPAEEDQA 235


                  ..
gi 1347662198 232 PE 233
Cdd:PRK14143  236 TP 237
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 72-219 3.74e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 73.83  E-value: 3.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  72 LEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMDSVDPETrqkdaavEQIMVGLEMT 151
Cdd:PRK14147   30 LRSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSLDAGLTAAGTEP-------SPLRDGLELT 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1347662198 152 AREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14147  103 YKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQKGYLLNERLLRPALVVVAK 170
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 37-218 1.12e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 73.31  E-value: 1.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  37 EADETAEEGAveAESNEETSPGDVPEEVPEEEEED-----LEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISN 111
Cdd:PRK14154   26 EAEEEQEEGG--GDGSQEMEPHREGLEFPSREKLEgqltrMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQ 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 112 FARDMLALSDNLHRAMDSVDPEtrqkDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAM-GEKFDHNLHEALFEMDDASK 190
Cdd:PRK14154  104 LITDLLPVADSLIHGLESPASE----DPQVKSMRDGMSLTLDLLHNTLAKHGVQVINPNpGDPFDPALHEAMSVQAVPDA 179

                         170       180
                  ....*....|....*....|....*...
gi 1347662198 191 PPGTVVQVVETGYVLKDRLLRPAKVGVS 218
Cdd:PRK14154  180 KPDTIIQVLQKGYQLNGRVLRAARVIVA 207
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 26-219 7.09e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 70.63  E-value: 7.09e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  26 QEPDAEKLPEGEADETAEEGAVEAESNEETSPGDVPEEvpeeeeedleatvaDLNDKLLRALAETENIRRRAVRDKEDAS 105
Cdd:PRK14156    7 NEEVEEEVEATETEETVEEVVEETPEKSELELANERAD--------------EFENKYLRAHAEMQNIQRRANEERQQLQ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 106 KYAISNFARDMLALSDNLHRAMdsvdpetrQKDAAVEQIMVGLEMTAREVNNAFERYGIKVIEAmgEKFDHNLHEALFEM 185
Cdd:PRK14156   73 RYRSQDLAKAILPSLDNLERAL--------AVEGLTDDVKKGLEMVQESLIQALKEEGVEEVAV--DSFDHNLHMAVQTL 142

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1347662198 186 D-DASKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14156  143 PaDDEHPADSIAQVFQKGYKLHERLLRPAMVVVYN 177
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 25-239 2.33e-14

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 69.77  E-value: 2.33e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  25 DQEPDAEKLPEGEADETAEEGAVEAESNEETSP-GDVPEEVPEEEEED-LEATVADLNDKLLRALAETENIRRRAVRDKE 102
Cdd:PRK14163    3 EETPGFEEKPDVPSGATPDDAEPKAASEEGAAPaGDAAATAGLTAQLDqVRTALGERTADLQRLQAEYQNYRRRVERDRV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 103 DASKYAISNFARDMLALSDNLHRAMDSvdpetrqkdaavEQIMVGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEAL 182
Cdd:PRK14163   83 TVKEIAVANLLSELLPVLDDVGRAREH------------GELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEAL 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1347662198 183 FEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSKGGAKETAANAEEPETVASKE 239
Cdd:PRK14163  151 MHSYAPDVTETTCVAILQPGYRIGERTIRPARVAVAEPQPGAQTAKAKEAEGADDKE 207
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 21-219 8.22e-14

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 68.02  E-value: 8.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  21 DTNLDQEPDAEKLPEGEADETAEEgAVEAESNEETSPGDVPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRD 100
Cdd:PRK14145    7 EINKEEEKDVNNLSSNEQMEGPPE-DEQAQQNQPQQQTVDEIEELKQKLQQKEVEAQEYLDIAQRLKAEFENYRKRTEKE 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 101 KEDASKYAISNFARDMLALSDNLHRAMDSVDPETRQKDaaveqimvGLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHE 180
Cdd:PRK14145   86 KSEMVEYGKEQVILELLPVMDNFERALASSGDYNSLKE--------GIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHH 157

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1347662198 181 ALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVSK 219
Cdd:PRK14145  158 AVMQEEVEGKQPNEIIEVFQKGYYLKDKVIRPSLVKVAK 196
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 1-219 4.85e-12

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 63.60  E-value: 4.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198   1 MNPEDNDNEIEPGAEATKTPDTNLDQEPDAEKLPEGEADETAEEGAVEAESNEETspgdvpEEVPEEEEEDLEATVADLN 80
Cdd:PRK14146    1 MAETSNNKTSEEAKANEKKSQSQTLEESKLENMNSEESQTITEETQEQAVEGAET------ETSLQKELDNAKKEIESLK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  81 DKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRaMDSVDPETRQKDAAVEqimvGLEMTAREVNNAFE 160
Cdd:PRK14146   75 DSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLER-VGATQNQSEELKPFVE----GVKMILKEFYSVLE 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1347662198 161 RYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKD----RLLRPAKVGVSK 219
Cdd:PRK14146  150 KSNVIRFDPKGEPFDPMSMEALSSEEGDQYSEETVIDVYQAGYYYKEnedkFTLRPARVRIGK 212
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 57-250 2.79e-11

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 61.55  E-value: 2.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  57 PGDVPEEVPEEEEEDLEATVADLNDKLLRALAETENIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMDSVDPETRQ 136
Cdd:PRK14142   30 PGDMPGGTAAADAAHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKHGDLESGP 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198 137 kdaaveqimvgLEMTAREVNNAFERYGIKVIEAMGEKFDHNLHEALFEMDDASKPPGTVV-QVVETGYVLKDRLLRPAKV 215
Cdd:PRK14142  110 -----------LKSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQHEGDGGQGSKPVIgTVMRQGYQLGEQVLRHALV 178

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1347662198 216 GVskggAKETAANAEEPETVASKE--GQTAYEDKGEE 250
Cdd:PRK14142  179 GV----VDTVVVDAAELESVDDGTavADTAENDQADQ 211
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 12-218 8.76e-11

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 59.97  E-value: 8.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  12 PGAEATKTPDTNLDQEPDAEKLPEGEADETAEEGAVEAESnEETSPGDVPEEVPEEEEEDLEATVADLNDKLLRALAETE 91
Cdd:PRK14157   30 SGADASAESGEQQDSAAQADANAGADAAPAAAEGEAKAAA-EKTGEAQSDSDDTLTPLGQAKKEAAEYLEALQRERAEFI 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347662198  92 NIRRRAVRDKEDASKYAISNFARDMLALSDNLHRAMdsvdpETRQKDAAVEQImvglemtAREVNNAFERYGIKVIEAMG 171
Cdd:PRK14157  109 NYRNRTQKEQDRFRQHGIIDVLTALLPALDDIDRIR-----EHSEMDDSFKAV-------AAKIDKAFEKFGVEKFGEKG 176

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1347662198 172 EKFDHNLHEALFEMDDASKPPGTVVQVVETGYVLKDRLLRPAKVGVS 218
Cdd:PRK14157  177 EDFDPTKHDAILHKPDPDAEKETVDTVVEAGYRIGDRVIRAARVVVA 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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