|
Name |
Accession |
Description |
Interval |
E-value |
| DdlA |
COG1181 |
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ... |
12-321 |
1.69e-98 |
|
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440794 [Multi-domain] Cd Length: 303 Bit Score: 292.40 E-value: 1.69e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 12 KILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKPQTFSEDINHYNNDyLCFNALHGTFGEDGTIQKILENKKI 91
Cdd:COG1181 2 RVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVEDLPAALKELKPD-VVFPALHGRGGEDGTIQGLLELLGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 92 RYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATNLDEIkiREIFEQFNS-FVVKPVSSGSSYGVQIIKDSKDLE 170
Cdd:COG1181 81 PYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRRGELADL--EAIEEELGLpLFVKPAREGSSVGVSKVKNAEELA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 171 NFVRNIennhniYKKHNELLIERYIAGRELTVAVVNKENIsEAVEVTEIISNNYFYDYQSKYSKGFSRHILPAKLPVKIY 250
Cdd:COG1181 159 AALEEA------FKYDDKVLVEEFIDGREVTVGVLGNGGP-RALPPIEIVPENGFYDYEAKYTDGGTEYICPARLPEELE 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1347645558 251 DNCLKYAKIVHDTIKCRNLSRSDFLYDNKN-IYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSSL 321
Cdd:COG1181 232 ERIQELALKAFRALGCRGYARVDFRLDEDGePYLLEVNTLPGMTPTSLLPKAAAAAGISYEELIERIIELAL 303
|
|
| ddl |
PRK01372 |
D-alanine--D-alanine ligase; Reviewed |
10-321 |
6.53e-92 |
|
D-alanine--D-alanine ligase; Reviewed
Pssm-ID: 234948 [Multi-domain] Cd Length: 304 Bit Score: 275.84 E-value: 6.53e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 10 MEKILILEGGFNEEHEISLNTAKEIKRSLTNLNI---SFDSLLVKPQTFSE---DInhynndylCFNALHGTFGEDGTIQ 83
Cdd:PRK01372 4 FGKVAVLMGGTSAEREVSLNSGAAVLAALREAGYdahPIDPGEDIAAQLKElgfDR--------VFNALHGRGGEDGTIQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 84 KILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATNLDEIKIREI-FEqfnsFVVKPVSSGSSYGVQI 162
Cdd:PRK01372 76 GLLELLGIPYTGSGVLASALAMDKLRTKLVWQAAGLPTPPWIVLTREEDLLAAIDKLgLP----LVVKPAREGSSVGVSK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 163 IKDSKDLENFVRNIEnnhniykKH-NELLIERYIAGRELTVAVVNkeniSEAVEVTEIISNNYFYDYQSKYSKGFSRHIL 241
Cdd:PRK01372 152 VKEEDELQAALELAF-------KYdDEVLVEKYIKGRELTVAVLG----GKALPVIEIVPAGEFYDYEAKYLAGGTQYIC 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 242 PAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKNI-YFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSS 320
Cdd:PRK01372 221 PAGLPAEIEAELQELALKAYRALGCRGWGRVDFMLDEDGKpYLLEVNTQPGMTSHSLVPMAARAAGISFSELVDRILEDA 300
|
.
gi 1347645558 321 L 321
Cdd:PRK01372 301 L 301
|
|
| D_ala_D_alaTIGR |
TIGR01205 |
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ... |
12-317 |
2.73e-74 |
|
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273498 [Multi-domain] Cd Length: 315 Bit Score: 231.02 E-value: 2.73e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 12 KILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKPQT--FSEDINHYNNDY--------LCFNALHGTFGEDGT 81
Cdd:TIGR01205 1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDIDKMGswTYKDLPQLILELgallegidVVFPVLHGRYGEDGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 82 IQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLK--ATNLDEIKIREIFEQFN-SFVVKPVSSGSSY 158
Cdd:TIGR01205 81 IQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTqnRASADELECEQVAEPLGfPVIVKPAREGSSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 159 GVQIIKDSKDLENFVRniennhNIYKKHNELLIERYIAGRELTVAVVNKENISEAVEVTEIIsnNYFYDYQSKYSKGFSR 238
Cdd:TIGR01205 161 GVSKVKSEEELQAALD------EAFEYDEEVLVEQFIKGRELEVSILGNEEALPIIEIVPEI--EGFYDYEAKYLDGSTE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 239 HILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYD-NKNIYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNII 317
Cdd:TIGR01205 233 YVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDeEGEIYLNEINTIPGMTAISLFPKAAAAAGIEFSQLVERIL 312
|
|
| Dala_Dala_lig_C |
pfam07478 |
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ... |
148-317 |
4.22e-39 |
|
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).
Pssm-ID: 429483 [Multi-domain] Cd Length: 204 Bit Score: 136.68 E-value: 4.22e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 148 VVKPVSSGSSYGVQIIKDSKDLENFVRNIennhniYKKHNELLIERYIAGRELTVAVVNKENIsEAVEVTEIISNNYFYD 227
Cdd:pfam07478 40 FVKPARLGSSVGVSKVESREELQAAIEEA------FQYDEKVLVEEGIEGREIECAVLGNEDP-EVSPVGEIVPSGGFYD 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 228 YQSKYSKGFSRHILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNK-NIYFLEINTQPGLTSISLVPEQLKHKN 306
Cdd:pfam07478 113 YEAKYIDDSAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDFFLTEDgEIVLNEVNTIPGFTSISMFPKLAAAAG 192
|
170
....*....|.
gi 1347645558 307 ISFDNLIQNII 317
Cdd:pfam07478 193 VSFPDLVDQLI 203
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DdlA |
COG1181 |
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, ... |
12-321 |
1.69e-98 |
|
D-alanine-D-alanine ligase or related ATP-grasp enzyme [Cell wall/membrane/envelope biogenesis, General function prediction only]; D-alanine-D-alanine ligase or related ATP-grasp enzyme is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440794 [Multi-domain] Cd Length: 303 Bit Score: 292.40 E-value: 1.69e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 12 KILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKPQTFSEDINHYNNDyLCFNALHGTFGEDGTIQKILENKKI 91
Cdd:COG1181 2 RVAVLFGGRSAEREVSLKSGRAVAAALDKAGYDVVPIGIDVEDLPAALKELKPD-VVFPALHGRGGEDGTIQGLLELLGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 92 RYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATNLDEIkiREIFEQFNS-FVVKPVSSGSSYGVQIIKDSKDLE 170
Cdd:COG1181 81 PYTGSGVLASALAMDKALTKRVLAAAGLPTPPYVVLRRGELADL--EAIEEELGLpLFVKPAREGSSVGVSKVKNAEELA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 171 NFVRNIennhniYKKHNELLIERYIAGRELTVAVVNKENIsEAVEVTEIISNNYFYDYQSKYSKGFSRHILPAKLPVKIY 250
Cdd:COG1181 159 AALEEA------FKYDDKVLVEEFIDGREVTVGVLGNGGP-RALPPIEIVPENGFYDYEAKYTDGGTEYICPARLPEELE 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1347645558 251 DNCLKYAKIVHDTIKCRNLSRSDFLYDNKN-IYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSSL 321
Cdd:COG1181 232 ERIQELALKAFRALGCRGYARVDFRLDEDGePYLLEVNTLPGMTPTSLLPKAAAAAGISYEELIERIIELAL 303
|
|
| ddl |
PRK01372 |
D-alanine--D-alanine ligase; Reviewed |
10-321 |
6.53e-92 |
|
D-alanine--D-alanine ligase; Reviewed
Pssm-ID: 234948 [Multi-domain] Cd Length: 304 Bit Score: 275.84 E-value: 6.53e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 10 MEKILILEGGFNEEHEISLNTAKEIKRSLTNLNI---SFDSLLVKPQTFSE---DInhynndylCFNALHGTFGEDGTIQ 83
Cdd:PRK01372 4 FGKVAVLMGGTSAEREVSLNSGAAVLAALREAGYdahPIDPGEDIAAQLKElgfDR--------VFNALHGRGGEDGTIQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 84 KILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATNLDEIKIREI-FEqfnsFVVKPVSSGSSYGVQI 162
Cdd:PRK01372 76 GLLELLGIPYTGSGVLASALAMDKLRTKLVWQAAGLPTPPWIVLTREEDLLAAIDKLgLP----LVVKPAREGSSVGVSK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 163 IKDSKDLENFVRNIEnnhniykKH-NELLIERYIAGRELTVAVVNkeniSEAVEVTEIISNNYFYDYQSKYSKGFSRHIL 241
Cdd:PRK01372 152 VKEEDELQAALELAF-------KYdDEVLVEKYIKGRELTVAVLG----GKALPVIEIVPAGEFYDYEAKYLAGGTQYIC 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 242 PAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKNI-YFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSS 320
Cdd:PRK01372 221 PAGLPAEIEAELQELALKAYRALGCRGWGRVDFMLDEDGKpYLLEVNTQPGMTSHSLVPMAARAAGISFSELVDRILEDA 300
|
.
gi 1347645558 321 L 321
Cdd:PRK01372 301 L 301
|
|
| D_ala_D_alaTIGR |
TIGR01205 |
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a ... |
12-317 |
2.73e-74 |
|
D-alanine--D-alanine ligase; This model describes D-Ala--D-Ala ligase, an enzyme that makes a required precursor of the bacterial cell wall. It also describes some closely related proteins responsible for resistance to glycopeptide antibiotics such as vancomycin. The mechanism of glyopeptide antibiotic resistance involves the production of D-alanine-D-lactate (VanA and VanB families) or D-alanine-D-serine (VanC). The seed alignment contains only chromosomally encoded D-ala--D-ala ligases, but a number of antibiotic resistance proteins score above the trusted cutoff of this model. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273498 [Multi-domain] Cd Length: 315 Bit Score: 231.02 E-value: 2.73e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 12 KILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKPQT--FSEDINHYNNDY--------LCFNALHGTFGEDGT 81
Cdd:TIGR01205 1 RVAVLFGGKSAEHEISLVSAAAVLKALRDLGYDVYPVDIDKMGswTYKDLPQLILELgallegidVVFPVLHGRYGEDGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 82 IQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLK--ATNLDEIKIREIFEQFN-SFVVKPVSSGSSY 158
Cdd:TIGR01205 81 IQGLLELMGIPYTGSGVLASALSMDKLLTKLLWKALGLPTPDYIVLTqnRASADELECEQVAEPLGfPVIVKPAREGSSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 159 GVQIIKDSKDLENFVRniennhNIYKKHNELLIERYIAGRELTVAVVNKENISEAVEVTEIIsnNYFYDYQSKYSKGFSR 238
Cdd:TIGR01205 161 GVSKVKSEEELQAALD------EAFEYDEEVLVEQFIKGRELEVSILGNEEALPIIEIVPEI--EGFYDYEAKYLDGSTE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 239 HILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYD-NKNIYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNII 317
Cdd:TIGR01205 233 YVIPAPLDEELEEKIKELALKAYKALGCRGLARVDFFLDeEGEIYLNEINTIPGMTAISLFPKAAAAAGIEFSQLVERIL 312
|
|
| ddl |
PRK01966 |
D-alanine--D-alanine ligase; |
10-321 |
3.35e-63 |
|
D-alanine--D-alanine ligase;
Pssm-ID: 234993 [Multi-domain] Cd Length: 333 Bit Score: 203.04 E-value: 3.35e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 10 MEKILILEGGFNEEHEISLNTAKEIKRSL---------------------TNLNISFDSLLVKPQTFSEDIN----HYNN 64
Cdd:PRK01966 3 KMRVALLFGGRSAEHEVSLVSAKSVLKALdkekyevvpigitkdgrwyliDADNMELADDDNDKEDLSLLILpsggSEEV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 65 DYLcFNALHGTFGEDGTIQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATNLDEIKIREIFEQF 144
Cdd:PRK01966 83 DVV-FPVLHGPPGEDGTIQGLLELLGIPYVGCGVLASALSMDKILTKRLLAAAGIPVAPYVVLTRGDWEEASLAEIEAKL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 145 N-SFVVKPVSSGSSYGVQIIKDSKDLEN-----FvrniennhniykKH-NELLIERYIAGRELTVAVVnkENISEAVEVT 217
Cdd:PRK01966 162 GlPVFVKPANLGSSVGISKVKNEEELAAaldlaF------------EYdRKVLVEQGIKGREIECAVL--GNDPKASVPG 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 218 EIISNNYFYDYQSKYSKGFSRHILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKN-IYFLEINTQPGLTSIS 296
Cdd:PRK01966 228 EIVKPDDFYDYEAKYLDGSAELIIPADLSEELTEKIRELAIKAFKALGCSGLARVDFFLTEDGeIYLNEINTMPGFTPIS 307
|
330 340
....*....|....*....|....*
gi 1347645558 297 LVPEQLKHKNISFDNLIQNIINSSL 321
Cdd:PRK01966 308 MYPKLWEASGLSYPELIDRLIELAL 332
|
|
| PRK14571 |
PRK14571 |
D-alanyl-alanine synthetase A; Provisional |
12-320 |
1.81e-58 |
|
D-alanyl-alanine synthetase A; Provisional
Pssm-ID: 184751 [Multi-domain] Cd Length: 299 Bit Score: 190.03 E-value: 1.81e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 12 KILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKpQTFSEDINHYNNDYLCFNALHGTFGEDGTIQKILENKKI 91
Cdd:PRK14571 2 RVALLMGGVSREREISLRSGERVKKALEKLGYEVTVFDVD-EDFLKKVDQLKSFDVVFNVLHGTFGEDGTLQAILDFLGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 92 RYTHSDSITSNIGFNKFLTKKKIQNTkiltaesflLKATNLDEIKIREIFEQFN-SFVVKPVSSGSSYGVQIIKDSKDLE 170
Cdd:PRK14571 81 RYTGSDAFSSMICFDKLLTYRFLKGT---------VEIPDFVEIKEFMKTSPLGyPCVVKPRREGSSIGVFICESDEEFQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 171 NFVRniennhNIYKKHNELLIERYIAGRELTVAVVNKENISEAVEVTEIISNNYFYDYQSKYSKGFSRHILPAKLPVKIY 250
Cdd:PRK14571 152 HALK------EDLPRYGSVIVQEYIPGREMTVSILETEKGFEVLPILELRPKRRFYDYVAKYTKGETEFILPAPLNPEEE 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 251 DNCLKYAKIVHDTIKCRNLSRSDFLYDNKNIYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSS 320
Cdd:PRK14571 226 RLVKETALKAFVEAGCRGFGRVDGIFSDGRFYFLEINTVPGLTELSDLPASAKAGGIEFEELVDIIIKSA 295
|
|
| PRK14569 |
PRK14569 |
D-alanyl-alanine synthetase A; Provisional |
11-320 |
1.55e-40 |
|
D-alanyl-alanine synthetase A; Provisional
Pssm-ID: 173033 [Multi-domain] Cd Length: 296 Bit Score: 143.28 E-value: 1.55e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 11 EKILILEGGFNEEHEISLNTAKEIKRSLTN-------LNISFDSLLVKPQTFSEDinhynndyLCFNALHGTFGEDGTIQ 83
Cdd:PRK14569 4 EKIVVLYGGDSPEREVSLKSGKAVLDSLISqgydavgVDASGKELVAKLLELKPD--------KCFVALHGEDGENGRVS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 84 KILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLL--KATNLDEIKIreifeqfnSFVVKPVSSGSSYGVQ 161
Cdd:PRK14569 76 ALLEMLEIKHTSSSMKSSVITMDKMISKEILMHHRMPTPMAKFLtdKLVAEDEISF--------PVAVKPSSGGSSIATF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 162 IIKDSKDLENFVRNIEnnhniykKHNELLIERYIAGRELTVAVVNKENISEavevTEIISNNYFYDYQSKYSkGFSRHIL 241
Cdd:PRK14569 148 KVKSIQELKHAYEEAS-------KYGEVMIEQWVTGKEITVAIVNDEVYSS----VWIEPQNEFYDYESKYS-GKSIYHS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 242 PAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNK-NIYFLEINTQPGLTSISLVPEQLKHKNISFDNLIQNIINSS 320
Cdd:PRK14569 216 PSGLCEQKELEVRQLAKKAYDLLGCSGHARVDFIYDDRgNFYIMEINSSPGMTDNSLSPKSAAAEGVDFDSFVKRIIEQA 295
|
|
| Dala_Dala_lig_C |
pfam07478 |
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the ... |
148-317 |
4.22e-39 |
|
D-ala D-ala ligase C-terminus; This family represents the C-terminal, catalytic domain of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF).
Pssm-ID: 429483 [Multi-domain] Cd Length: 204 Bit Score: 136.68 E-value: 4.22e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 148 VVKPVSSGSSYGVQIIKDSKDLENFVRNIennhniYKKHNELLIERYIAGRELTVAVVNKENIsEAVEVTEIISNNYFYD 227
Cdd:pfam07478 40 FVKPARLGSSVGVSKVESREELQAAIEEA------FQYDEKVLVEEGIEGREIECAVLGNEDP-EVSPVGEIVPSGGFYD 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 228 YQSKYSKGFSRHILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNK-NIYFLEINTQPGLTSISLVPEQLKHKN 306
Cdd:pfam07478 113 YEAKYIDDSAQIVVPADLEEEQEEQIQELALKAYKALGCRGLARVDFFLTEDgEIVLNEVNTIPGFTSISMFPKLAAAAG 192
|
170
....*....|.
gi 1347645558 307 ISFDNLIQNII 317
Cdd:pfam07478 193 VSFPDLVDQLI 203
|
|
| PRK14572 |
PRK14572 |
D-alanyl-alanine synthetase A; Provisional |
10-321 |
5.07e-34 |
|
D-alanyl-alanine synthetase A; Provisional
Pssm-ID: 173036 [Multi-domain] Cd Length: 347 Bit Score: 127.33 E-value: 5.07e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 10 MEKILILEGGFNEEHEISLNTAKEIKRSLTNLNISFDSLLVKPQ----------------------TFSEDINHYNN--- 64
Cdd:PRK14572 1 MAKIAVFFGGSSTEHSISIRTGCFICATLHTMGHSVKPILLTPDggwvvptvyrpsipdesgnsedLFLEEFQKANGvse 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 65 -------DYL-CFNALHGTFGEDGTIQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESF---LLKATNLD 133
Cdd:PRK14572 81 padisqlDADiAFLGLHGGAGEDGRIQGFLDTLGIPYTGSGVLASALAMDKTRANQIFLQSGQKVAPFFeleKLKYLNSP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 134 EIKIREI----FEQFnsfvVKPVSSGSSYGVQIIKDSKDLENFVrniennHNIYKKHNELLIERYIAGRELTVAVV---- 205
Cdd:PRK14572 161 RKTLLKLeslgFPQF----LKPVEGGSSVSTYKITNAEQLMTLL------ALIFESDSKVMSQSFLSGTEVSCGVLeryr 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 206 NKENISEAVEVTEIISNNYFYDYQSKYSKGFSRHILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKNIYFLE 285
Cdd:PRK14572 231 GGKRNPIALPATEIVPGGEFFDFESKYKQGGSEEITPARISDQEMKRVQELAIRAHESLGCKGYSRTDFIIVDGEPHILE 310
|
330 340 350
....*....|....*....|....*....|....*.
gi 1347645558 286 INTQPGLTSISLVPEQLKHKNISFDNLIQNIINSSL 321
Cdd:PRK14572 311 TNTLPGMTETSLIPQQAKAAGINMEEVFTDLIEIGL 346
|
|
| PRK14570 |
PRK14570 |
D-alanyl-alanine synthetase A; Provisional |
10-318 |
1.25e-22 |
|
D-alanyl-alanine synthetase A; Provisional
Pssm-ID: 173034 [Multi-domain] Cd Length: 364 Bit Score: 96.44 E-value: 1.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 10 MEKILIL-EGGFNEEHEISLNTAKEIKRSLTNLN----------------ISFDSLLVKPQTFSEDIN-----------H 61
Cdd:PRK14570 1 MKKNLMLiFGGVSFEHEISLRSAYGIYSALLKLDkyniysvfidkctgiwYLLDSVPDPPKLIKRDVLpivslipgcgiF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 62 YNNDYL----CFNALHGTFGEDGTIQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKILTAESFLLKATN--LDEI 135
Cdd:PRK14570 81 VNNKNLeidvVFPIVHGRTGEDGAIQGFLKVMDIPCVGAGILGSAISINKYFCKLLLKSFNIPLVPFIGFRKYDyfLDKE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 136 KIREIFEQFNSF--VVKPVSSGSSYGVQIIKDSKDLENFVRNIennhniYKKHNELLIERYIAGRELTVAVVNKENISEA 213
Cdd:PRK14570 161 GIKKDIKEVLGYpvIVKPAVLGSSIGINVAYNENQIEKCIEEA------FKYDLTVVIEKFIEAREIECSVIGNEQIKIF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 214 VEVTEIISNNYFYDYQSKYSKGFSRHI---LPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKN--IYFLEINT 288
Cdd:PRK14570 235 TPGEIVVQDFIFYDYDAKYSTIPGNSIvfnIPAHLDTKHLLDIKEYAFLTYKNLELRGMARIDFLIEKDTglIYLNEINT 314
|
330 340 350
....*....|....*....|....*....|
gi 1347645558 289 QPGLTSISLVPEQLKHKNISFDNLIQNIIN 318
Cdd:PRK14570 315 IPGFTDISMFAKMCEHDGLQYKSLVDNLID 344
|
|
| AccC |
COG0439 |
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ... |
106-304 |
2.91e-19 |
|
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis
Pssm-ID: 440208 [Multi-domain] Cd Length: 263 Bit Score: 85.31 E-value: 2.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 106 NKFLTKKKIQNTKILTAESFLLkaTNLDEIkiREIFEQFNS-FVVKPVSSGSSYGVQIIKDSKDLENFVRNIENNHNIYK 184
Cdd:COG0439 54 DKVLMREALAAAGVPVPGFALV--DSPEEA--LAFAEEIGYpVVVKPADGAGSRGVRVVRDEEELEAALAEARAEAKAGS 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 185 KHNELLIERYIAGRELTV-AVVNKENIsEAVEVTE-IISNNYFYDYqskyskgfsRHILPAKLPVKIYDNCLKYAKIVHD 262
Cdd:COG0439 130 PNGEVLVEEFLEGREYSVeGLVRDGEV-VVCSITRkHQKPPYFVEL---------GHEAPSPLPEELRAEIGELVARALR 199
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1347645558 263 TIK-CRNLSRSDFLYD-NKNIYFLEINTQPG----------LTSISLVPEQLKH 304
Cdd:COG0439 200 ALGyRRGAFHTEFLLTpDGEPYLIEINARLGgehippltelATGVDLVREQIRL 253
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
18-321 |
1.55e-13 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 71.39 E-value: 1.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 18 GGFNEEHEISLNTAKEIKRSLTN-------LNISFDSLLVKPQTFSEDINHYNNDYL--------------CFNALHGTF 76
Cdd:PRK14573 459 GGKSCEHDISLLSAKNIAKYLSPefydvsyFLINRQGLWETVSSLETAIEEDSGKSVlsseiaqalakvdvVLPILHGPF 538
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 77 GEDGTIQKILENKKIRYTHSDSITSNIGFNKFLTKKKIQNTKI--LTAESFLLKATNLD-EIKIREIFEQFnSF--VVKP 151
Cdd:PRK14573 539 GEDGTMQGFLEIIGKPYTGPSLAFSAIAMDKVLTKRFASDVGVpvVPYQPLTLAGWKREpELCLAHIVEAF-SFpmFVKT 617
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 152 VSSGSSYGVQIIKDSKDL-----ENFVRNiennhniykkhNELLIERYIAG-RELTVAVVNKENISEAV-EVTEIISNNY 224
Cdd:PRK14573 618 AHLGSSIGVFEVHNVEELrdkisEAFLYD-----------TDVFVEESRLGsREIEVSCLGDGSSAYVIaGPHERRGSGG 686
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 225 FYDYQSKYskGFS-----RHILPAKLPVKIYDNCLKYAKIVHDTIKCRNLSRSDFLYDNKNIYFL-EINTQPGLTSISLV 298
Cdd:PRK14573 687 FIDYQEKY--GLSgkssaQIVFDLDLSKESQEQVLELAERIYRLLQGKGSCRIDFFLDEEGNFWLsEMNPIPGMTEASPF 764
|
330 340
....*....|....*....|...
gi 1347645558 299 PEQLKHKNISFDNLIQNIINSSL 321
Cdd:PRK14573 765 LTAFVRKGWTYEQIVHQLIIDGL 787
|
|
| Dala_Dala_lig_N |
pfam01820 |
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the ... |
12-94 |
1.18e-11 |
|
D-ala D-ala ligase N-terminus; This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF). This domain is structurally related to the PreATP-grasp domain.
Pssm-ID: 460346 [Multi-domain] Cd Length: 118 Bit Score: 60.70 E-value: 1.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 12 KILILEGGFNEEHEISLNTAKEIKRSL-----------------------TNLNISFDSLLVKPQTFSEDINHY----NN 64
Cdd:pfam01820 1 KVAVLFGGRSSEHEVSLVSARSVLKALdkekyevipigitkdgrlgeaalRELASDDGLLLEVDDAPDGGPAGLlfgpNV 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 1347645558 65 DYLC------FNALHGTFGEDGTIQKILENKKIRYT 94
Cdd:pfam01820 81 LELLievdvvFPVLHGPNGEDGTLQGLLELAGIPYV 116
|
|
| LysX |
COG0189 |
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ... |
137-292 |
4.38e-08 |
|
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis
Pssm-ID: 439959 [Multi-domain] Cd Length: 289 Bit Score: 53.41 E-value: 4.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 137 IREIFEQFN-SFVVKPVSSGSSYGVQIIKDSKDLENFVRNIENNHniykkHNELLIERYIA---GRELTVAVVNKenisE 212
Cdd:COG0189 123 LRAFLEELGgPVVLKPLDGSGGRGVFLVEDEDALESILEALTELG-----SEPVLVQEFIPeedGRDIRVLVVGG----E 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 213 AVEVTEIISNNyfYDYQSKYSKGFSrhILPAKLPVKIYDNCLKYAKIVHDtikcrNLSRSDFLYDNKNIYFLEINTQPGL 292
Cdd:COG0189 194 PVAAIRRIPAE--GEFRTNLARGGR--AEPVELTDEERELALRAAPALGL-----DFAGVDLIEDDDGPLVLEVNVTPGF 264
|
|
| PRK12767 |
PRK12767 |
carbamoyl phosphate synthase-like protein; Provisional |
103-287 |
8.33e-06 |
|
carbamoyl phosphate synthase-like protein; Provisional
Pssm-ID: 237195 [Multi-domain] Cd Length: 326 Bit Score: 46.80 E-value: 8.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 103 IGFNKFLTKKKIQNTKILTAESFLLkaTNLDEIKIREIFEQFN-SFVVKPVSSGSSYGVQIIKDSKDLENFvrniennhn 181
Cdd:PRK12767 108 ICNDKWLTYEFLKENGIPTPKSYLP--ESLEDFKAALAKGELQfPLFVKPRDGSASIGVFKVNDKEELEFL--------- 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347645558 182 iYKKHNELLIERYIAGRELTVAVV---NKENISE-AVEVTEIISNNyfydyqskYSKGFSRhilpaklpvkiydnclKYA 257
Cdd:PRK12767 177 -LEYVPNLIIQEFIEGQEYTVDVLcdlNGEVISIvPRKRIEVRAGE--------TSKGVTV----------------KDP 231
|
170 180 190
....*....|....*....|....*....|....*.
gi 1347645558 258 KIVHDTIKCRNLSRS------DFLYDNKNIYFLEIN 287
Cdd:PRK12767 232 ELFKLAERLAEALGArgplniQCFVTDGEPYLFEIN 267
|
|
| ATP-grasp_4 |
pfam13535 |
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent ... |
147-202 |
5.44e-04 |
|
ATP-grasp domain; This family includes a diverse set of enzymes that possess ATP-dependent carboxylate-amine ligase activity.
Pssm-ID: 316093 [Multi-domain] Cd Length: 160 Bit Score: 39.96 E-value: 5.44e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1347645558 147 FVVKPVSSGSSYGVQIIKDSKDLENFVRNIENN----HNIYKKH----NELLIERYIAGRELTV 202
Cdd:pfam13535 5 CVIKPSVGFFSVGVYKINNREEWKAAFAAIREEieqwKEMYPEAvvdgGSFLVEEYIEGEEFAV 68
|
|
| PRK08654 |
PRK08654 |
acetyl-CoA carboxylase biotin carboxylase subunit; |
273-303 |
8.98e-03 |
|
acetyl-CoA carboxylase biotin carboxylase subunit;
Pssm-ID: 236325 [Multi-domain] Cd Length: 499 Bit Score: 37.66 E-value: 8.98e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1347645558 273 DFLYDNKNIYFLEINTQ--------PGLTSISLVPEQLK 303
Cdd:PRK08654 275 EFLYSNGNFYFLEMNTRlqvehpitEMVTGIDIVKEQIK 313
|
|
| |
