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Conserved domains on  [gi|1347628265|gb|PPR39391|]
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Secretory immunoglobulin A-binding protein EsiB [Alphaproteobacteria bacterium MarineAlpha9_Bin5]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
73-284 2.94e-61

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 195.15  E-value: 2.94e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628265  73 ATQVLAETSDAEKAYDDGNYLKALELWLPLAEDGDISAQYNVATLYRMGRGVPANLVAAVGWYRSAAEQGHARSQVNLGR 152
Cdd:COG0790    28 AAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGL 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628265 153 LYLEGRGVKRDVFQALAWFQKAADSDDSLGHYFLGRQYVRGVGVPQNYGQAASFFRRSAEQGLRDAAYELAVLYKRGEGI 232
Cdd:COG0790   108 MYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGV 187
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1347628265 233 GRDDGEAIKWFSAAAYAGHVDAQFSMGVIYEEGQGVPVDLGRAYFWYNVAAA 284
Cdd:COG0790   188 PKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
73-284 2.94e-61

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 195.15  E-value: 2.94e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628265  73 ATQVLAETSDAEKAYDDGNYLKALELWLPLAEDGDISAQYNVATLYRMGRGVPANLVAAVGWYRSAAEQGHARSQVNLGR 152
Cdd:COG0790    28 AAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGL 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628265 153 LYLEGRGVKRDVFQALAWFQKAADSDDSLGHYFLGRQYVRGVGVPQNYGQAASFFRRSAEQGLRDAAYELAVLYKRGEGI 232
Cdd:COG0790   108 MYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGV 187
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1347628265 233 GRDDGEAIKWFSAAAYAGHVDAQFSMGVIYEEGQGVPVDLGRAYFWYNVAAA 284
Cdd:COG0790   188 PKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
144-179 2.80e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.01  E-value: 2.80e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1347628265  144 ARSQVNLGRLYLEGRGVKRDVFQALAWFQKAADSDD 179
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
144-176 2.16e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 43.66  E-value: 2.16e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1347628265 144 ARSQVNLGRLYLEGRGVKRDVFQALAWFQKAAD 176
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAE 33
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
73-284 2.94e-61

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 195.15  E-value: 2.94e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628265  73 ATQVLAETSDAEKAYDDGNYLKALELWLPLAEDGDISAQYNVATLYRMGRGVPANLVAAVGWYRSAAEQGHARSQVNLGR 152
Cdd:COG0790    28 AAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGL 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628265 153 LYLEGRGVKRDVFQALAWFQKAADSDDSLGHYFLGRQYVRGVGVPQNYGQAASFFRRSAEQGLRDAAYELAVLYKRGEGI 232
Cdd:COG0790   108 MYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGV 187
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1347628265 233 GRDDGEAIKWFSAAAYAGHVDAQFSMGVIYEEGQGVPVDLGRAYFWYNVAAA 284
Cdd:COG0790   188 PKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
95-293 7.96e-53

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 173.58  E-value: 7.96e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628265  95 ALELWLPLAEDGDISAQYNVATLYRMGRGVPANLVAAVGWYRSAAEQGHARSQVNLGRLYLEGRGVKRDVFQALAWFQKA 174
Cdd:COG0790    14 AAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKA 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628265 175 ADSDDSLGHYFLGRQYVRGVGVPQNYGQAASFFRRSAEQGLRDAAYELAVLYKRGEGIGRDDGEAIKWFSAAAYAGHVDA 254
Cdd:COG0790    94 AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADA 173
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1347628265 255 QFSMGVIYEEGQGVPVDLGRAYFWYNVAAASGHVTSESN 293
Cdd:COG0790   174 QYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYN 212
TPR COG0790
TPR repeat [General function prediction only];
118-293 3.29e-34

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 125.43  E-value: 3.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628265 118 YRMGRGVPANLVAAVGWYRSAAEQGHARSQVNLGRLYLEGRGVKRDVFQALAWFQKAADSDDSLGHYFLGRQYVRGVGVP 197
Cdd:COG0790     1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628265 198 QNYGQAASFFRRSAEQGLRDAAYELAVLYKRGEGIGRDDGEAIKWFSAAAYAGHVDAQFSMGVIYEEGQGVPVDLGRAYF 277
Cdd:COG0790    81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAE 160
                         170
                  ....*....|....*.
gi 1347628265 278 WYNVAAASGHVTSESN 293
Cdd:COG0790   161 WYRKAAEQGDADAQYN 176
TPR COG0790
TPR repeat [General function prediction only];
91-213 4.96e-34

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 124.66  E-value: 4.96e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628265  91 NYLKALELWLPLAEDGDISAQYNVATLYRMGRGVPANLVAAVGWYRSAAEQGHARSQVNLGRLYLEGRGVKRDVFQALAW 170
Cdd:COG0790   118 DYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEW 197
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1347628265 171 FQKAADSDDSLGHYFLGRQYVRGVGVPQNYGQAASFFRRSAEQ 213
Cdd:COG0790   198 YRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
144-179 2.80e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.01  E-value: 2.80e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1347628265  144 ARSQVNLGRLYLEGRGVKRDVFQALAWFQKAADSDD 179
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
144-176 2.16e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 43.66  E-value: 2.16e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1347628265 144 ARSQVNLGRLYLEGRGVKRDVFQALAWFQKAAD 176
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
252-287 4.65e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 42.55  E-value: 4.65e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1347628265  252 VDAQFSMGVIYEEGQGVPVDLGRAYFWYNVAAASGH 287
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
110-143 4.93e-06

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 42.55  E-value: 4.93e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1347628265  110 AQYNVATLYRMGRGVPANLVAAVGWYRSAAEQGH 143
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
108-142 1.60e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 41.35  E-value: 1.60e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1347628265 108 ISAQYNVATLYRMGRGVPANLVAAVGWYRSAAEQG 142
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
252-286 5.24e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 39.81  E-value: 5.24e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1347628265 252 VDAQFSMGVIYEEGQGVPVDLGRAYFWYNVAAASG 286
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
217-250 7.54e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 39.43  E-value: 7.54e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1347628265 217 DAAYELAVLYKRGEGIGRDDGEAIKWFSAAAYAG 250
Cdd:pfam08238   2 EAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
217-251 1.26e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 38.69  E-value: 1.26e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1347628265  217 DAAYELAVLYKRGEGIGRDDGEAIKWFSAAAYAGH 251
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
180-214 4.84e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.15  E-value: 4.84e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1347628265  180 SLGHYFLGRQYVRGVGVPQNYGQAASFFRRSAEQG 214
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
180-214 2.22e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 35.19  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1347628265 180 SLGHYFLGRQYVRGVGVPQNYGQAASFFRRSAEQG 214
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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