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Conserved domains on  [gi|1347628258|gb|PPR39384|]
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Lactonase drp35 [Alphaproteobacteria bacterium MarineAlpha9_Bin5]

Protein Classification

SMP-30/gluconolactonase/LRE family protein( domain architecture ID 11465288)

SMP-30/gluconolactonase/LRE family protein similar to Staphylococcus lactonase drp35 and Zymomonas mobilis gluconolactonase, which hydrolyzes the gluconolactone formed by glucose-fructose oxidoreductase to form gluconate;

CATH:  2.120.10.30
EC:  3.1.1.-
Gene Ontology:  GO:0005515|GO:0046872|GO:0016787
PubMed:  9868369
SCOP:  4003251

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1-284 2.36e-58

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 187.41  E-value: 2.36e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258   1 MPDGSVIVVEIARGTLTRVLLDGRK-EVIAKTGGGPNGAAIGPDGACYVCNNGGfawernsrsggmrpvrqaddyitgRI 79
Cdd:COG3386    16 DPDGRLYWVDIPGGRIHRYDPDGGAvEVFAEPSGRPNGLAFDPDGRLLVADHGR------------------------GL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  80 ERIDLATGKIERLYDQCGdHKLNGPNDIVFDQKGNMWFTDLGKSRPRdmdrGAVYWARPDGsEIKEVVQPITTPNGIGLS 159
Cdd:COG3386    72 VRFDPADGEVTVLADEYG-KPLNRPNDGVVDPDGRLYFTDMGEYLPT----GALYRVDPDG-SLRVLADGLTFPNGIAFS 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 160 PDEKILYVAETEGARLYSFPIEGNGIVEtlpfpesiNGGRFVTCDGGFRRFDSLAVEAGGNICIATLMTGGITVARPGGG 239
Cdd:COG3386   146 PDGRTLYVADTGAGRIYRFDLDADGTLG--------NRRVFADLPDGPGGPDGLAVDADGNLWVALWGGGGVVRFDPDGE 217

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1347628258 240 TVEFIKTEDPFTTNICFGGNKLQTAYLT----FSWQGLLVACDWPRPGL 284
Cdd:COG3386   218 LLGRIELPERRPTNVAFGGPDLRTLYVTtarsLPLAGALFRVRVDVPGL 266
 
Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1-284 2.36e-58

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 187.41  E-value: 2.36e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258   1 MPDGSVIVVEIARGTLTRVLLDGRK-EVIAKTGGGPNGAAIGPDGACYVCNNGGfawernsrsggmrpvrqaddyitgRI 79
Cdd:COG3386    16 DPDGRLYWVDIPGGRIHRYDPDGGAvEVFAEPSGRPNGLAFDPDGRLLVADHGR------------------------GL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  80 ERIDLATGKIERLYDQCGdHKLNGPNDIVFDQKGNMWFTDLGKSRPRdmdrGAVYWARPDGsEIKEVVQPITTPNGIGLS 159
Cdd:COG3386    72 VRFDPADGEVTVLADEYG-KPLNRPNDGVVDPDGRLYFTDMGEYLPT----GALYRVDPDG-SLRVLADGLTFPNGIAFS 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 160 PDEKILYVAETEGARLYSFPIEGNGIVEtlpfpesiNGGRFVTCDGGFRRFDSLAVEAGGNICIATLMTGGITVARPGGG 239
Cdd:COG3386   146 PDGRTLYVADTGAGRIYRFDLDADGTLG--------NRRVFADLPDGPGGPDGLAVDADGNLWVALWGGGGVVRFDPDGE 217

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1347628258 240 TVEFIKTEDPFTTNICFGGNKLQTAYLT----FSWQGLLVACDWPRPGL 284
Cdd:COG3386   218 LLGRIELPERRPTNVAFGGPDLRTLYVTtarsLPLAGALFRVRVDVPGL 266
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 3-267 1.28e-40

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 141.25  E-value: 1.28e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258   3 DGSVIVVEIARGTLTRVLLDGRKEVIAKTGGgPNGAAI-GPDGACYVCNNGGFAwernsrsggmrpvrqaddyitgrieR 81
Cdd:pfam08450  11 EGALYWVDILGGRIHRLDPATGKETVWDTPG-PVGAIApRDDGGLIVALKDGVA-------------------------L 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  82 IDLATGKIERLYD-QCGDHKLNGPNDIVFDQKGNMWFTDLGKSRPRDMDRGAVYWARPDGSeIKEVVQPITTPNGIGLSP 160
Cdd:pfam08450  65 LDLATGELTPLADpEDDDWPLNRFNDGKVDPDGRFWFGTMGDDEAPGGDPGALYRLDPDGK-LTRVLDGLTISNGLAWSP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 161 DEKILYVAETEGARLYSFPIEGNGivetlpfPESINGGRFVTCDGGFRRFDSLAVEAGGNICIATLMTGGITVARPGGGT 240
Cdd:pfam08450 144 DGRTLYFADSPARKIWAYDYDLDG-------GLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGGGKVVRFDPDGKL 216

                         250       260
                  ....*....|....*....|....*..
gi 1347628258 241 VEFIKTEDPFTTNICFGGNKLQTAYLT 267
Cdd:pfam08450 217 LREIELPAKRPTSCAFGGPDLRTLYVT 243
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 34-224 1.36e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.47  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  34 GPNGAAIGPDGACYVCNNGGfawernsrsggmrpvrqaddyitGRIERIDlATGKIERLYDQCGDH--KLNGPNDIVFDQ 111
Cdd:cd05819     9 NPQGIAVDSSGNIYVADTGN-----------------------NRIQVFD-PDGNFITSFGSFGSGdgQFNEPAGVAVDS 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 112 KGNMWFTDLGKSRPRDMDRGAVYWARPDGSEIKEvvQPITTPNGIGLSPDEKIlYVAETEGARLYSFPIEGNGIVETlpf 191
Cdd:cd05819    65 DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGD--GEFNGPRGIAVDSSGNI-YVADTGNHRIQKFDPDGEFLTTF--- 138

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1347628258 192 pesingGRFVTCDGGFRRFDSLAVEAGGNICIA 224
Cdd:cd05819   139 ------GSGGSGPGQFNGPTGVAVDSDGNIYVA 165
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 35-168 7.62e-04

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 40.34  E-value: 7.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  35 PNGAAIGPDGACYVCNNGGFAWERNSrsggmrpvrqaddyitGRIERIDLaTGKIERLYDqcGdhkLNGPNDIVFDQKGN 114
Cdd:NF033206  205 PTGVAVGPDGALYVSELTGFPFPPGR----------------ARVYRVDP-GGAPTVYAT--G---FTGLTDLAFDPDGN 262

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1347628258 115 MWFTDL-GKSRPRDMDRGAVYWARPDGSeIKEVVQPITTPNGIGLSPDEKiLYVA 168
Cdd:NF033206  263 LYVLELaGGGLLKGDPTGSLIRIAPDGT-RTTLLDGLELPTGLAVGPDGT-LYVT 315
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 2-52 2.04e-03

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 39.18  E-value: 2.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258   2 PDGSVIVVEIAR---------GTLTRVLLDGRKEVIAKTGGGPNGAAIGPDGACYVCNNG 52
Cdd:NF033206  259 PDGNLYVLELAGggllkgdptGSLIRIAPDGTRTTLLDGLELPTGLAVGPDGTLYVTNNG 318
 
Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1-284 2.36e-58

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 187.41  E-value: 2.36e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258   1 MPDGSVIVVEIARGTLTRVLLDGRK-EVIAKTGGGPNGAAIGPDGACYVCNNGGfawernsrsggmrpvrqaddyitgRI 79
Cdd:COG3386    16 DPDGRLYWVDIPGGRIHRYDPDGGAvEVFAEPSGRPNGLAFDPDGRLLVADHGR------------------------GL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  80 ERIDLATGKIERLYDQCGdHKLNGPNDIVFDQKGNMWFTDLGKSRPRdmdrGAVYWARPDGsEIKEVVQPITTPNGIGLS 159
Cdd:COG3386    72 VRFDPADGEVTVLADEYG-KPLNRPNDGVVDPDGRLYFTDMGEYLPT----GALYRVDPDG-SLRVLADGLTFPNGIAFS 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 160 PDEKILYVAETEGARLYSFPIEGNGIVEtlpfpesiNGGRFVTCDGGFRRFDSLAVEAGGNICIATLMTGGITVARPGGG 239
Cdd:COG3386   146 PDGRTLYVADTGAGRIYRFDLDADGTLG--------NRRVFADLPDGPGGPDGLAVDADGNLWVALWGGGGVVRFDPDGE 217

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1347628258 240 TVEFIKTEDPFTTNICFGGNKLQTAYLT----FSWQGLLVACDWPRPGL 284
Cdd:COG3386   218 LLGRIELPERRPTNVAFGGPDLRTLYVTtarsLPLAGALFRVRVDVPGL 266
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 3-267 1.28e-40

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 141.25  E-value: 1.28e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258   3 DGSVIVVEIARGTLTRVLLDGRKEVIAKTGGgPNGAAI-GPDGACYVCNNGGFAwernsrsggmrpvrqaddyitgrieR 81
Cdd:pfam08450  11 EGALYWVDILGGRIHRLDPATGKETVWDTPG-PVGAIApRDDGGLIVALKDGVA-------------------------L 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  82 IDLATGKIERLYD-QCGDHKLNGPNDIVFDQKGNMWFTDLGKSRPRDMDRGAVYWARPDGSeIKEVVQPITTPNGIGLSP 160
Cdd:pfam08450  65 LDLATGELTPLADpEDDDWPLNRFNDGKVDPDGRFWFGTMGDDEAPGGDPGALYRLDPDGK-LTRVLDGLTISNGLAWSP 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 161 DEKILYVAETEGARLYSFPIEGNGivetlpfPESINGGRFVTCDGGFRRFDSLAVEAGGNICIATLMTGGITVARPGGGT 240
Cdd:pfam08450 144 DGRTLYFADSPARKIWAYDYDLDG-------GLISNRRVFADFKPGLGRPDGMAVDAEGNVWVARWGGGKVVRFDPDGKL 216

                         250       260
                  ....*....|....*....|....*..
gi 1347628258 241 VEFIKTEDPFTTNICFGGNKLQTAYLT 267
Cdd:pfam08450 217 LREIELPAKRPTSCAFGGPDLRTLYVT 243
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
2-249 2.90e-13

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 68.12  E-value: 2.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258   2 PDGSVIVVEIARGTLTRV-LLDGR-KEVIAKTGGGPNGAAIGPDGACYVCNNGGfawernsrsggmrpvrqaddyitGRI 79
Cdd:COG4257    26 PDGAVWFTDQGGGRIGRLdPATGEfTEYPLGGGSGPHGIAVDPDGNLWFTDNGN-----------------------NRI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  80 ERIDLATGKIERLydqCGDHKLNGPNDIVFDQKGNMWFTDLGKSRPRDMDrgavywarPDGSEIKEVVQPIT--TPNGIG 157
Cdd:COG4257    83 GRIDPKTGEITTF---ALPGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLD--------PATGEVTEFPLPTGgaGPYGIA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 158 LSPDEKiLYVAETEGARLYSFPIEgNGIVETLPFPESINGGRFVTCDggfrrfdslaveAGGNICIATLMTGGITVARPG 237
Cdd:COG4257   152 VDPDGN-LWVTDFGANAIGRIDPD-TGTLTEYALPTPGAGPRGLAVD------------PDGNLWVADTGSGRIGRFDPK 217

                         250
                  ....*....|..
gi 1347628258 238 GGTVEFIKTEDP 249
Cdd:COG4257   218 TGTVTEYPLPGG 229
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 34-224 1.36e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.47  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  34 GPNGAAIGPDGACYVCNNGGfawernsrsggmrpvrqaddyitGRIERIDlATGKIERLYDQCGDH--KLNGPNDIVFDQ 111
Cdd:cd05819     9 NPQGIAVDSSGNIYVADTGN-----------------------NRIQVFD-PDGNFITSFGSFGSGdgQFNEPAGVAVDS 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 112 KGNMWFTDLGKSRPRDMDRGAVYWARPDGSEIKEvvQPITTPNGIGLSPDEKIlYVAETEGARLYSFPIEGNGIVETlpf 191
Cdd:cd05819    65 DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGD--GEFNGPRGIAVDSSGNI-YVADTGNHRIQKFDPDGEFLTTF--- 138

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1347628258 192 pesingGRFVTCDGGFRRFDSLAVEAGGNICIA 224
Cdd:cd05819   139 ------GSGGSGPGQFNGPTGVAVDSDGNIYVA 165
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 2-221 3.12e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 47.70  E-value: 3.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258   2 PDGSVIVVEIARGTLTRVLLDGrkEVIAKTGG---------GPNGAAIGPDGACYVCNNGGfawernsrsggmrpvrqad 72
Cdd:cd05819    64 SDGNLYVADTGNHRIQKFDPDG--NFLASFGGsgdgdgefnGPRGIAVDSSGNIYVADTGN------------------- 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  73 dyitGRIERIDlATGKIERLYDQ--CGDHKLNGPNDIVFDQKGNMWFTDLGKSRPRDMDrgavywarPDGSEIKEVVQPI 150
Cdd:cd05819   123 ----HRIQKFD-PDGEFLTTFGSggSGPGQFNGPTGVAVDSDGNIYVADTGNHRIQVFD--------PDGNFLTTFGSTG 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1347628258 151 TT------PNGIGLSPDEKIlYVAETEGARLYSFPIEGNGIVETlpfpesingGRFVTCDGGFRRFDSLAVEAGGNI 221
Cdd:cd05819   190 TGpgqfnyPTGIAVDSDGNI-YVADSGNNRVQVFDPDGAGFGGN---------GNFLGSDGQFNRPSGLAVDSDGNL 256
Arylesterase pfam01731
Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1. ...
 131-169 5.82e-05

Arylesterase; This family consists of arylesterases (Also known as serum paraoxonase) EC:3.1.1.2. These enzymes hydrolyse organophosphorus esters such as paraoxon and are found in the liver and blood. They confer resistance to organophosphate toxicity. Human arylesterase (PON1) is associated with HDL and may protect against LDL oxidation.


Pssm-ID: 334656  Cd Length: 86  Bit Score: 40.91  E-value: 5.82e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1347628258 131 GAVYWarpDGSEIKEVVQPITTPNGIGLSPDEKILYVAE 169
Cdd:pfam01731  37 GVVYY---SPSEVKVVASGFSFANGINYSPDKKYIYVAS 72
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
3-174 7.09e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 7.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258   3 DGSVIVVEIARGTLTRVLldgrkeviaKTGGGPNGAAIGPDGAC-YVCNNGGfawernsrsggmrpvrqaddyitGRIER 81
Cdd:COG3391    89 SGRVSVIDLATGKVVATI---------PVGGGPRGLAVDPDGGRlYVADSGN-----------------------GRVSV 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  82 IDLATGKIERLYDQCgdhklNGPNDIVFDQKGN-MWFTDLGksrprdMDRGAVYWARPDGSEiKEVVQPITT---PNGIG 157
Cdd:COG3391   137 IDTATGKVVATIPVG-----AGPHGIAVDPDGKrLYVANSG------SNTVSVIVSVIDTAT-GKVVATIPVgggPVGVA 204

                         170
                  ....*....|....*..
gi 1347628258 158 LSPDEKILYVAETEGAR 174
Cdd:COG3391   205 VSPDGRRLYVANRGSNT 221
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
73-200 3.66e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 3.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  73 DYITGRIERIDLATGKIERLYDQcGDHklngPNDIVFDQKGNMWFTDlgksrprDMDRGAVYWARPDGSEIKEVVQPITT 152
Cdd:COG3391    86 NSGSGRVSVIDLATGKVVATIPV-GGG----PRGLAVDPDGGRLYVA-------DSGNGRVSVIDTATGKVVATIPVGAG 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1347628258 153 PNGIGLSPDEKILYVAETEGAR----LYSFPIEGNGIVETLPFPESINGGRF 200
Cdd:COG3391   154 PHGIAVDPDGKRLYVANSGSNTvsviVSVIDTATGKVVATIPVGGGPVGVAV 205
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 35-168 7.62e-04

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 40.34  E-value: 7.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  35 PNGAAIGPDGACYVCNNGGFAWERNSrsggmrpvrqaddyitGRIERIDLaTGKIERLYDqcGdhkLNGPNDIVFDQKGN 114
Cdd:NF033206  205 PTGVAVGPDGALYVSELTGFPFPPGR----------------ARVYRVDP-GGAPTVYAT--G---FTGLTDLAFDPDGN 262

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1347628258 115 MWFTDL-GKSRPRDMDRGAVYWARPDGSeIKEVVQPITTPNGIGLSPDEKiLYVA 168
Cdd:NF033206  263 LYVLELaGGGLLKGDPTGSLIRIAPDGT-RTTLLDGLELPTGLAVGPDGT-LYVT 315
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
101-259 8.78e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.00  E-value: 8.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 101 LNGPNDIVFDQKGNMWFTDLGksrprdmdRGAVYWARPDGSEIKEVVQP-ITTPNGIGLSPDEKIlYVAETEGARLYSF- 178
Cdd:COG4257    16 GSGPRDVAVDPDGAVWFTDQG--------GGRIGRLDPATGEFTEYPLGgGSGPHGIAVDPDGNL-WFTDNGNNRIGRId 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 179 PIEGNgiVETLPFPesinggrfvtcdGGFRRFDSLAVEAGGNICIATLMTGGITVARPGGGTVEFIK--TEDPFTTNICF 256
Cdd:COG4257    87 PKTGE--ITTFALP------------GGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVTEFPlpTGGAGPYGIAV 152


                  ...
gi 1347628258 257 GGN 259
Cdd:COG4257   153 DPD 155
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 31-183 9.10e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 39.96  E-value: 9.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  31 TGGGPNGAAIGPDGACYVCnnggfawernsrsggmrpvrqadDYITGRIERIDLaTGKIERLYDQCG--DHKLNGPNDIV 108
Cdd:cd14956    58 QFGRPRGLAVDKDGWLYVA-----------------------DYWGDRIQVFTL-TGELQTIGGSSGsgPGQFNAPRGVA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 109 FDQKGNMWFTDLGKSRPRDMDrgavywarPDGSEIKEVVQP------ITTPNGIGLSPDeKILYVAETEGARLYSFPIEG 182
Cdd:cd14956   114 VDADGNLYVADFGNQRIQKFD--------PDGSFLRQWGGTgiepgsFNYPRGVAVDPD-GTLYVADTYNDRIQVFDNDG 184


                  .
gi 1347628258 183 N 183
Cdd:cd14956   185 A 185
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 2-52 2.04e-03

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 39.18  E-value: 2.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258   2 PDGSVIVVEIAR---------GTLTRVLLDGRKEVIAKTGGGPNGAAIGPDGACYVCNNG 52
Cdd:NF033206  259 PDGNLYVLELAGggllkgdptGSLIRIAPDGTRTTLLDGLELPTGLAVGPDGTLYVTNNG 318
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 76-178 3.70e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 38.34  E-value: 3.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  76 TGRIERIDLATGKIeRLYDQCGDHKLNGPNDIVFDQKGNMWFTDLGksrprdmdRGAVYWARPDGSEIKEVVQPITT--P 153
Cdd:cd14962    32 RGAVFVFDLPNGKV-FVIGNAGPNRFVSPIGVAIDANGNLYVSDAE--------LGKVFVFDRDGKFLRAIGAGALFkrP 102

                          90       100
                  ....*....|....*....|....*
gi 1347628258 154 NGIGLSPDEKILYVAETEGARLYSF 178
Cdd:cd14962   103 TGIAVDPAGKRLYVVDTLAHKVKVF 127
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
81-257 6.19e-03

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 38.05  E-value: 6.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258  81 RIDLATGKIERlYDQcGDHKLNGPNDIVFDQKGNMWFTDLGksrprdmdRGAVYWARPDGSEIKEVVQPITTPNGI-GLS 159
Cdd:COG3292   295 RLDPKTGKFKR-YNP-NGLPSNSVYSILEDSDGNLWIGTSG--------GGLYRYDPKTGKFTKFSEDNGLSNNFIrSIL 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347628258 160 PDEK-ILYVAETEGarLYSFPIEGNGIVE--TLPFPESINGGRfVTCdggfrrfdsLAVEAGGNICIATlMTGGITVARP 236
Cdd:COG3292   365 EDSDgNLWVGTNGG--LYRLDPKTGKFTNftHDPDKNGLSSNY-INS---------IFEDSDGRLWIGT-DGGGLYRYDP 431

                         170       180
                  ....*....|....*....|.
gi 1347628258 237 GGGTVEFIKTEDPFTTNICFG 257
Cdd:COG3292   432 KTGKFKHFTTKDGLPSNTIYS 452
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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