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Conserved domains on  [gi|1347602351|gb|PPR15953|]
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hypothetical protein CFH33_01095 [Alphaproteobacteria bacterium MarineAlpha9_Bin3]

Protein Classification

AAA family ATPase( domain architecture ID 11431245)

AAA family ATPase with an AAA (ATPases Associated with various cellular Activities) domain functions as a modulator of stress response pathways and may have a chaperone-like role for the maturation of specific protein complexes or for the insertion of cofactors into proteins; similar to MoxR that is involved in the formation of active methanol dehydrogenase

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  16072036|11916378|15037234|17897320|18466635
SCOP:  2000039

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 11-269 2.30e-57

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


:

Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 185.37  E-value: 2.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  11 YVATDELALAVNAAITLERPLLIKGEPGTGKTMLAEEVAKSLEKSLLRWHVKSTTKAQQGLYEYDAVSRlrdsqlgdarv 90
Cdd:COG0714    14 YVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQ----------- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  91 eDINNYIKRGVLWdafeakeKPVLLIDEVDKADIEFPNDLLLELDKMEFYVYEtkQNIVARERPIVIITSN-----NEKD 165
Cdd:COG0714    83 -TGEFEFRPGPLF-------ANVLLADEINRAPPKTQSALLEAMEERQVTIPG--GTYKLPEPFLVIATQNpieqeGTYP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351 166 LPDAFLRRC-FFHYIRFPDEETMKSIIEVHFP-------------------------KIKKKLVDSALKSFFEVREVPGI 219
Cdd:COG0714   153 LPEAQLDRFlLKLYIGYPDAEEEREILRRHTGrhlaevepvlspeellalqelvrqvHVSEAVLDYIVDLVRATREHPDL 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1347602351 220 KKKPSTSELLDWIKLLLA-------EDVPPEllrekDSKNALPPL--YGALLKNEADVH 269
Cdd:COG0714   233 RKGPSPRASIALLRAARAlalldgrDYVTPD-----DVKAVAGPVlkHRLILSPEADAE 286
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 11-269 2.30e-57

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 185.37  E-value: 2.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  11 YVATDELALAVNAAITLERPLLIKGEPGTGKTMLAEEVAKSLEKSLLRWHVKSTTKAQQGLYEYDAVSRlrdsqlgdarv 90
Cdd:COG0714    14 YVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQ----------- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  91 eDINNYIKRGVLWdafeakeKPVLLIDEVDKADIEFPNDLLLELDKMEFYVYEtkQNIVARERPIVIITSN-----NEKD 165
Cdd:COG0714    83 -TGEFEFRPGPLF-------ANVLLADEINRAPPKTQSALLEAMEERQVTIPG--GTYKLPEPFLVIATQNpieqeGTYP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351 166 LPDAFLRRC-FFHYIRFPDEETMKSIIEVHFP-------------------------KIKKKLVDSALKSFFEVREVPGI 219
Cdd:COG0714   153 LPEAQLDRFlLKLYIGYPDAEEEREILRRHTGrhlaevepvlspeellalqelvrqvHVSEAVLDYIVDLVRATREHPDL 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1347602351 220 KKKPSTSELLDWIKLLLA-------EDVPPEllrekDSKNALPPL--YGALLKNEADVH 269
Cdd:COG0714   233 RKGPSPRASIALLRAARAlalldgrDYVTPD-----DVKAVAGPVlkHRLILSPEADAE 286
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 29-182 1.71e-12

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 63.70  E-value: 1.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  29 RPLLIKGEPGTGKTMLAEEVAKSLEKSLLRwhvksttkaqqgLYEYDAVSRlrdsqLGDARVEDINNYIKRGVLWDAFEA 108
Cdd:cd00009    20 KNLLLYGPPGTGKTTLARAIANELFRPGAP------------FLYLNASDL-----LEGLVVAELFGHFLVRLLFELAEK 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1347602351 109 KEKPVLLIDEVDKADIEFPNDLLLELDKMEFYVYETKQNIVarerpIVIITSNNEKDLPDAFLRRCFFHyIRFP 182
Cdd:cd00009    83 AKPGVLFIDEIDSLSRGAQNALLRVLETLNDLRIDRENVRV-----IGATNRPLLGDLDRALYDRLDIR-IVIP 150
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 29-185 1.59e-11

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 60.85  E-value: 1.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351   29 RPLLIKGEPGTGKTMLAEEVAKSLEKSLLRWHVKSTTKAQQGLYEYDAVSRLRDSQLGDARVEDINNYIKRGvlwdafEA 108
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALA------RK 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1347602351  109 KEKPVLLIDEVDKADIEFPNDLLLELDkmefyVYETKQNIVARERPIVIITSNNEKDLPDAFLRRCFFHYIRFPDEE 185
Cdd:smart00382  77 LKPDVLILDEITSLLDAEQEALLLLLE-----ELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLLIL 148
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 30-174 3.27e-10

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 56.92  E-value: 3.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  30 PLLIKGEPGTGKTMLAEEVAKSLEKSllRWHV----KSTTKAQ-QGLYEYDAV-SRLRDSQLGDArvedinnyikrgvlw 103
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNR--PVFYvqltRDTTEEDlFGRRNIDPGgASWVDGPLVRA--------------- 63

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1347602351 104 dafeAKEKPVLLIDEVDKADIEFPNDLLLELDKMEFYVYETKQNIVARERPIVIITSNNE-----KDLPDAFLRRC 174
Cdd:pfam07728  64 ----AREGEIAVLDEINRANPDVLNSLLSLLDERRLLLPDGGELVKAAPDGFRLIATMNPldrglNELSPALRSRF 135
PRK05564 PRK05564
DNA polymerase III subunit delta'; Validated
 32-208 2.23e-03

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180132 [Multi-domain]  Cd Length: 313  Bit Score: 38.86  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  32 LIKGEPGTGKTMLAEEVA-KSLEKSLLRWHV-----KSTTKAQQGlyeydavsrlrdsqlgdarVEDINNYIKrgvlwda 105
Cdd:PRK05564   30 IIVGEDGIGKSLLAKEIAlKILGKSQQREYVdiiefKPINKKSIG-------------------VDDIRNIIE------- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351 106 fEAKEKPVllidEVDKADIefpndLLLELDKMEfyvyETKQNIVAR--ERP-----IVIITSNNEKDLpDAFLRRCFFHY 178
Cdd:PRK05564   84 -EVNKKPY----EGDKKVI-----IIYNSEKMT----EQAQNAFLKtiEEPpkgvfIILLCENLEQIL-DTIKSRCQIYK 148

                         170       180       190
                  ....*....|....*....|....*....|
gi 1347602351 179 IRFPDEETMKSIIEVHFPKIKKKLVDSALK 208
Cdd:PRK05564  149 LNRLSKEEIEKFISYKYNDIKEEEKKSAIA 178
 
Name Accession Description Interval E-value
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 11-269 2.30e-57

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 185.37  E-value: 2.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  11 YVATDELALAVNAAITLERPLLIKGEPGTGKTMLAEEVAKSLEKSLLRWHVKSTTKAQQGLYEYDAVSRlrdsqlgdarv 90
Cdd:COG0714    14 YVGQEELIELVLIALLAGGHLLLEGVPGVGKTTLAKALARALGLPFIRIQFTPDLLPSDILGTYIYDQQ----------- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  91 eDINNYIKRGVLWdafeakeKPVLLIDEVDKADIEFPNDLLLELDKMEFYVYEtkQNIVARERPIVIITSN-----NEKD 165
Cdd:COG0714    83 -TGEFEFRPGPLF-------ANVLLADEINRAPPKTQSALLEAMEERQVTIPG--GTYKLPEPFLVIATQNpieqeGTYP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351 166 LPDAFLRRC-FFHYIRFPDEETMKSIIEVHFP-------------------------KIKKKLVDSALKSFFEVREVPGI 219
Cdd:COG0714   153 LPEAQLDRFlLKLYIGYPDAEEEREILRRHTGrhlaevepvlspeellalqelvrqvHVSEAVLDYIVDLVRATREHPDL 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1347602351 220 KKKPSTSELLDWIKLLLA-------EDVPPEllrekDSKNALPPL--YGALLKNEADVH 269
Cdd:COG0714   233 RKGPSPRASIALLRAARAlalldgrDYVTPD-----DVKAVAGPVlkHRLILSPEADAE 286
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 29-182 1.71e-12

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 63.70  E-value: 1.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  29 RPLLIKGEPGTGKTMLAEEVAKSLEKSLLRwhvksttkaqqgLYEYDAVSRlrdsqLGDARVEDINNYIKRGVLWDAFEA 108
Cdd:cd00009    20 KNLLLYGPPGTGKTTLARAIANELFRPGAP------------FLYLNASDL-----LEGLVVAELFGHFLVRLLFELAEK 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1347602351 109 KEKPVLLIDEVDKADIEFPNDLLLELDKMEFYVYETKQNIVarerpIVIITSNNEKDLPDAFLRRCFFHyIRFP 182
Cdd:cd00009    83 AKPGVLFIDEIDSLSRGAQNALLRVLETLNDLRIDRENVRV-----IGATNRPLLGDLDRALYDRLDIR-IVIP 150
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 31-199 4.60e-12

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 65.70  E-value: 4.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  31 LLIKGEPGTGKTMLAEEVAKSLEKSLLRwhVKsttkaqqglyeydaVSRLRDSQLGD--ARVEDInnyikrgvlWDAFEA 108
Cdd:COG0464   194 LLLYGPPGTGKTLLARALAGELGLPLIE--VD--------------LSDLVSKYVGEteKNLREV---------FDKARG 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351 109 KEKPVLLIDEVDK--ADIEFPND---------LLLELDKMEFYVyetkqnivarerpIVIITSNNEKDLPDAFLRRCFFH 177
Cdd:COG0464   249 LAPCVLFIDEADAlaGKRGEVGDgvgrrvvntLLTEMEELRSDV-------------VVIAATNRPDLLDPALLRRFDEI 315

                         170       180
                  ....*....|....*....|...
gi 1347602351 178 -YIRFPDEETMKSIIEVHFPKIK 199
Cdd:COG0464   316 iFFPLPDAEERLEIFRIHLRKRP 338
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 29-185 1.59e-11

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 60.85  E-value: 1.59e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351   29 RPLLIKGEPGTGKTMLAEEVAKSLEKSLLRWHVKSTTKAQQGLYEYDAVSRLRDSQLGDARVEDINNYIKRGvlwdafEA 108
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALA------RK 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1347602351  109 KEKPVLLIDEVDKADIEFPNDLLLELDkmefyVYETKQNIVARERPIVIITSNNEKDLPDAFLRRCFFHYIRFPDEE 185
Cdd:smart00382  77 LKPDVLILDEITSLLDAEQEALLLLLE-----ELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRRIVLLLIL 148
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 30-174 3.27e-10

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 56.92  E-value: 3.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  30 PLLIKGEPGTGKTMLAEEVAKSLEKSllRWHV----KSTTKAQ-QGLYEYDAV-SRLRDSQLGDArvedinnyikrgvlw 103
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNR--PVFYvqltRDTTEEDlFGRRNIDPGgASWVDGPLVRA--------------- 63

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1347602351 104 dafeAKEKPVLLIDEVDKADIEFPNDLLLELDKMEFYVYETKQNIVARERPIVIITSNNE-----KDLPDAFLRRC 174
Cdd:pfam07728  64 ----AREGEIAVLDEINRANPDVLNSLLSLLDERRLLLPDGGELVKAAPDGFRLIATMNPldrglNELSPALRSRF 135
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 31-182 5.18e-10

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 56.06  E-value: 5.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  31 LLIKGEPGTGKTMLAEEVAKSLEKSLLRWhvksttkaqqglyeydAVSRLRDSQLGDaRVEDINNYIKRgvlwdaFEAKE 110
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEI----------------SGSELVSKYVGE-SEKRLRELFEA------AKKLA 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351 111 KPVLLIDEVDK-------ADIEFPND----LLLELDKmefyvYETKQNIVarerpIVIITSNNEKDLPDAFLRRCFFHyI 179
Cdd:pfam00004  58 PCVIFIDEIDAlagsrgsGGDSESRRvvnqLLTELDG-----FTSSNSKV-----IVIAATNRPDKLDPALLGRFDRI-I 126


                  ...
gi 1347602351 180 RFP 182
Cdd:pfam00004 127 EFP 129
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 25-173 2.85e-09

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 54.98  E-value: 2.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  25 ITLERPLLIKGEPGTGKTMLAEEVAKSLEKSLLRwhVKSTTKAQQGLYEydavsrlrdsqlGDARVEDINNYIKRgvlwd 104
Cdd:cd19481    23 LGLPKGILLYGPPGTGKTLLAKALAGELGLPLIV--VKLSSLLSKYVGE------------SEKNLRKIFERARR----- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351 105 afeaKEKPVLLIDEVDKADIEFP------------NDLLLELDkmefyvyetkqNIVARERPIVIITSNNEKDLPDAFLR 172
Cdd:cd19481    84 ----LAPCILFIDEIDAIGRKRDssgesgelrrvlNQLLTELD-----------GVNSRSKVLVIAATNRPDLLDPALLR 148


                  .
gi 1347602351 173 R 173
Cdd:cd19481   149 P 149
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
29-192 4.78e-08

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 52.58  E-value: 4.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  29 RPLLIKGEPGTGKTMLAEEVAKSLEKSLLrwHVKSTTkaqqglyeydavsrLRDSQLGD--ARVEDinnyikrgvLWDaf 106
Cdd:COG1223    36 RKILFYGPPGTGKTMLAEALAGELKLPLL--TVRLDS--------------LIGSYLGEtaRNLRK---------LFD-- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351 107 EAKEKP-VLLIDEVD--KADIEFPND----------LLLELDKMEFYVyetkqnivarerpIVIITSNNEKDLPDAFLRR 173
Cdd:COG1223    89 FARRAPcVIFFDEFDaiAKDRGDQNDvgevkrvvnaLLQELDGLPSGS-------------VVIAATNHPELLDSALWRR 155

                         170       180
                  ....*....|....*....|.
gi 1347602351 174 cFFHYIRF--PDEETMKSIIE 192
Cdd:COG1223   156 -FDEVIEFplPDKEERKEILE 175
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 32-161 5.14e-08

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 51.43  E-value: 5.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  32 LIKGEPGTGKTMLAEEVAKSLEKSLLRWHVKSTTKAQqglyEYDAVSRLRDSQLGDARVEDinnyikRGVLWDAFEAKEK 111
Cdd:pfam07724   7 LFLGPTGVGKTELAKALAELLFGDERALIRIDMSEYM----EEHSVSRLIGAPPGYVGYEE------GGQLTEAVRRKPY 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1347602351 112 PVLLIDEVDKADIEFPNDLLLELDKMefyVYETKQNIVARERPIVII-TSN 161
Cdd:pfam07724  77 SIVLIDEIEKAHPGVQNDLLQILEGG---TLTDKQGRTVDFKNTLFImTGN 124
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 23-194 1.19e-05

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 45.77  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  23 AAITLERP--LLIKGEPGTGKTMLAEEVAKSLEKSLLrwHVKSttkaqqglyeydavSRLRDSQLGD--ARVEDInnyik 98
Cdd:COG1222   105 RKYGIEPPkgVLLYGPPGTGKTLLAKAVAGELGAPFI--RVRG--------------SELVSKYIGEgaRNVREV----- 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  99 rgvlwdaFE-AKEKP--VLLIDEVD------KADIEFP------NDLLLELDKMEfyvyetkqnivARERPIVIITSNNE 163
Cdd:COG1222   164 -------FElAREKApsIIFIDEIDaiaarrTDDGTSGevqrtvNQLLAELDGFE-----------SRGDVLIIAATNRP 225

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1347602351 164 KDLPDAFLR--RcFFHYIRF--PDEETMKSIIEVH 194
Cdd:COG1222   226 DLLDPALLRpgR-FDRVIEVplPDEEAREEILKIH 259
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
15-134 8.11e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 40.60  E-value: 8.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  15 DELALAVNAAITLERP--LLIKGEPGTGKTMLAEEVAKSLEKSLLRWHVKSTT---KAQQGLYEYDAVSRLRDSQLGDAR 89
Cdd:COG1474    36 EELASALRPALRGERPsnVLIYGPTGTGKTAVAKYVLEELEEEAEERGVDVRVvyvNCRQASTRYRVLSRILEELGSGED 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1347602351  90 VEdinnyiKRGV--------LWDAFEAKEKPVLLI-DEVDKADIEFPNDLLLEL 134
Cdd:COG1474   116 IP------STGLstdelfdrLYEALDERDGVLVVVlDEIDYLVDDEGDDLLYQL 163
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 15-173 1.84e-03

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 38.31  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  15 DELALAVNAAITLERP-----------LLIKGEPGTGKTMLAEEVAKSL---EKSLLRwhvksttkAQQGLY-EYDAVSR 79
Cdd:cd19499    17 DEAVKAVSDAIRRARAglsdpnrpigsFLFLGPTGVGKTELAKALAELLfgdEDNLIR--------IDMSEYmEKHSVSR 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  80 LRDSQLGdarvedINNYIKRGVLWDAFEAKEKPVLLIDEVDKADIEFPNDLLLELDKMEFyvYETKQNIVARERPIVIIT 159
Cdd:cd19499    89 LIGAPPG------YVGYTEGGQLTEAVRRKPYSVVLLDEIEKAHPDVQNLLLQVLDDGRL--TDSHGRTVDFKNTIIIMT 160

                         170
                  ....*....|....
gi 1347602351 160 SNNekdLPDAFLRR 173
Cdd:cd19499   161 SNH---FRPEFLNR 171
PRK05564 PRK05564
DNA polymerase III subunit delta'; Validated
 32-208 2.23e-03

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180132 [Multi-domain]  Cd Length: 313  Bit Score: 38.86  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  32 LIKGEPGTGKTMLAEEVA-KSLEKSLLRWHV-----KSTTKAQQGlyeydavsrlrdsqlgdarVEDINNYIKrgvlwda 105
Cdd:PRK05564   30 IIVGEDGIGKSLLAKEIAlKILGKSQQREYVdiiefKPINKKSIG-------------------VDDIRNIIE------- 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351 106 fEAKEKPVllidEVDKADIefpndLLLELDKMEfyvyETKQNIVAR--ERP-----IVIITSNNEKDLpDAFLRRCFFHY 178
Cdd:PRK05564   84 -EVNKKPY----EGDKKVI-----IIYNSEKMT----EQAQNAFLKtiEEPpkgvfIILLCENLEQIL-DTIKSRCQIYK 148

                         170       180       190
                  ....*....|....*....|....*....|
gi 1347602351 179 IRFPDEETMKSIIEVHFPKIKKKLVDSALK 208
Cdd:PRK05564  149 LNRLSKEEIEKFISYKYNDIKEEEKKSAIA 178
RecD COG0507
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ...
 14-58 3.64e-03

ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440273 [Multi-domain]  Cd Length: 514  Bit Score: 38.42  E-value: 3.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1347602351  14 TDELALAVNAAITLERPLLIKGEPGTGKTMLAEEVAKSLEKSLLR 58
Cdd:COG0507   126 SDEQREAVALALTTRRVSVLTGGAGTGKTTTLRALLAALEALGLR 170
AAA_22 pfam13401
AAA domain;
28-135 5.58e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 36.17  E-value: 5.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347602351  28 ERPLLIKGEPGTGKTMLAEEVAKSLEK---SLLRWHVKSTTKAQQgLYEyDAVSRLRDSQLGDARVEDINNYIKRGVLwd 104
Cdd:pfam13401   5 AGILVLTGESGTGKTTLLRRLLEQLPEvrdSVVFVDLPSGTSPKD-LLR-ALLRALGLPLSGRLSKEELLAALQQLLL-- 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1347602351 105 afEAKEKPVLLIDEVDKADIEFPNDLLLELD 135
Cdd:pfam13401  81 --ALAVAVVLIIDEAQHLSLEALEELRDLLN 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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