|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
37-362 |
2.92e-81 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 251.40 E-value: 2.92e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 37 TARPQAITETTEINGRIQAIGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEADAEAKRAAVDQAQAQLDYAD 116
Cdd:COG0845 2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 117 LALGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRIGRIQVTLGNVVGPSSgALA 196
Cdd:COG0845 82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT-PLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 197 TVVSQDPAYVVFPISVNRLLQLReefaaqgglEAMKIRLRLPDGRLYREVGKLQFVDVAVARDTDSIILRGTIANPplag 276
Cdd:COG0845 161 TIADLDPLEVEFDVPESDLARLK---------VGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNP---- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 277 gGRELTHDEMVRVLLEGSKPREVLAIPRAAILTDQQGDYVYVVSDKNVAERRRVKLGQSTAQIASVIDGLKAGDQVIVEG 356
Cdd:COG0845 228 -DGLLRPGMFVRVRIVLGERENALLVPASAVVRDGGGAYVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSG 306
|
....*.
gi 1347339825 357 VQRARP 362
Cdd:COG0845 307 LQRLRD 312
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
33-363 |
2.47e-60 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 197.54 E-value: 2.47e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 33 VGTITARPQAITETTEINGRIQAIGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEADAEAKRAAVDQAQAQL 112
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 113 DYADLALGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRIGRIQVTLGNVVGPsS 192
Cdd:TIGR01730 81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTA-G 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 193 GALATVVSQDPAYVVFPISVNRLLQLREEFAAQggleamkIRLRLPDGRLYreVGKLQFVDVAVARDTDSIILRGTIANP 272
Cdd:TIGR01730 160 QTLATIVDLDPLEADFSVPERDLPQLRRGQTLT-------VELDALPGEEF--KGKLRFIDPRVDSGTGTVRVRATFPNP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 273 --PLAGGgrelthdEMVRVLLEGSKPREVLAIPRAAILTDQQGDYVYVVSDKNVAERRRVKLGQSTAQIASVIDGLKAGD 350
Cdd:TIGR01730 231 dgRLLPG-------MFGRVTISLKVRSSAIVVPTQAVIEDLNGKYVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGD 303
|
330
....*....|...
gi 1347339825 351 QVIVEGVQRARPN 363
Cdd:TIGR01730 304 QIVTAGVVKLRDG 316
|
|
| PRK15030 |
PRK15030 |
multidrug efflux RND transporter periplasmic adaptor subunit AcrA; |
24-362 |
2.66e-45 |
|
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
Pssm-ID: 184990 [Multi-domain] Cd Length: 397 Bit Score: 160.26 E-value: 2.66e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 24 QMPGGGPPAVGTITARPQAITETTEINGRIQAIGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEADAEAKRA 103
Cdd:PRK15030 31 QQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 104 AVDQAQAQLDYADLALGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRIGRIQVT 183
Cdd:PRK15030 111 DLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 184 LGNVV-GPSSGALATVVSQDPAYVVFPISVNRLLQLREEFaAQGGLE----AMKIRLRLPDGRLYREVGKLQFVDVAVAR 258
Cdd:PRK15030 191 EGALVqNGQATALATVQQLDPIYVDVTQSSNDFLRLKQEL-ANGTLKqengKAKVSLITSDGIKFPQDGTLEFSDVTVDQ 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 259 DTDSIILRGTIANPplaggGRELTHDEMVRVLL-EGSKPREVLaIPRAAILTDQQGD-YVYVVSDKNVAERRRVKLGQST 336
Cdd:PRK15030 270 TTGSITLRAIFPNP-----DHTLLPGMFVRARLeEGLNPNAIL-VPQQGVTRTPRGDaTVLVVGADDKVETRPIVASQAI 343
|
330 340
....*....|....*....|....*.
gi 1347339825 337 AQIASVIDGLKAGDQVIVEGVQRARP 362
Cdd:PRK15030 344 GDKWLVTEGLKAGDRVVISGLQKVRP 369
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
40-354 |
4.96e-28 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 112.13 E-value: 4.96e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 40 PQAITETTEINGRIQAIGRVD-LTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEADAEAKRAAVDQAQAQLDYADLA 118
Cdd:pfam00529 1 LAPLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 119 LGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRIGRIQVTLGNVVGPSSGALATV 198
Cdd:pfam00529 81 LDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLAT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 199 VSQ-DPAYVVFPISVNRLLQLREEFAAQGGLEAM----KIRLRLPDGRLYREV----GKLQFVDVAVARDTDSIILRGTI 269
Cdd:pfam00529 161 VAQlDQIYVQITQSAAENQAEVRSELSGAQLQIAeaeaELKLAKLDLERTEIRapvdGTVAFLSVTVDGGTVSAGLRLMF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 270 ANPPlaggGRELTHDEMVRVLLEGSKPREVLAIPRAAILTDQQGDY-VYVVSDKNVAERRRVKLGQSTAQIASVIDGLKA 348
Cdd:pfam00529 241 VVPE----DNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFtGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSA 316
|
....*.
gi 1347339825 349 GDQVIV 354
Cdd:pfam00529 317 GALVRL 322
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
37-362 |
2.92e-81 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 251.40 E-value: 2.92e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 37 TARPQAITETTEINGRIQAIGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEADAEAKRAAVDQAQAQLDYAD 116
Cdd:COG0845 2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 117 LALGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRIGRIQVTLGNVVGPSSgALA 196
Cdd:COG0845 82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT-PLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 197 TVVSQDPAYVVFPISVNRLLQLReefaaqgglEAMKIRLRLPDGRLYREVGKLQFVDVAVARDTDSIILRGTIANPplag 276
Cdd:COG0845 161 TIADLDPLEVEFDVPESDLARLK---------VGQPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNP---- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 277 gGRELTHDEMVRVLLEGSKPREVLAIPRAAILTDQQGDYVYVVSDKNVAERRRVKLGQSTAQIASVIDGLKAGDQVIVEG 356
Cdd:COG0845 228 -DGLLRPGMFVRVRIVLGERENALLVPASAVVRDGGGAYVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSG 306
|
....*.
gi 1347339825 357 VQRARP 362
Cdd:COG0845 307 LQRLRD 312
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
33-363 |
2.47e-60 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 197.54 E-value: 2.47e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 33 VGTITARPQAITETTEINGRIQAIGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEADAEAKRAAVDQAQAQL 112
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 113 DYADLALGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRIGRIQVTLGNVVGPsS 192
Cdd:TIGR01730 81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTA-G 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 193 GALATVVSQDPAYVVFPISVNRLLQLREEFAAQggleamkIRLRLPDGRLYreVGKLQFVDVAVARDTDSIILRGTIANP 272
Cdd:TIGR01730 160 QTLATIVDLDPLEADFSVPERDLPQLRRGQTLT-------VELDALPGEEF--KGKLRFIDPRVDSGTGTVRVRATFPNP 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 273 --PLAGGgrelthdEMVRVLLEGSKPREVLAIPRAAILTDQQGDYVYVVSDKNVAERRRVKLGQSTAQIASVIDGLKAGD 350
Cdd:TIGR01730 231 dgRLLPG-------MFGRVTISLKVRSSAIVVPTQAVIEDLNGKYVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGD 303
|
330
....*....|...
gi 1347339825 351 QVIVEGVQRARPN 363
Cdd:TIGR01730 304 QIVTAGVVKLRDG 316
|
|
| PRK15030 |
PRK15030 |
multidrug efflux RND transporter periplasmic adaptor subunit AcrA; |
24-362 |
2.66e-45 |
|
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
Pssm-ID: 184990 [Multi-domain] Cd Length: 397 Bit Score: 160.26 E-value: 2.66e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 24 QMPGGGPPAVGTITARPQAITETTEINGRIQAIGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEADAEAKRA 103
Cdd:PRK15030 31 QQGGQQMPAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIEAGVSLYQIDPATYQATYDSAKG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 104 AVDQAQAQLDYADLALGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRIGRIQVT 183
Cdd:PRK15030 111 DLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETARINLAYTKVTSPISGRIGKSNVT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 184 LGNVV-GPSSGALATVVSQDPAYVVFPISVNRLLQLREEFaAQGGLE----AMKIRLRLPDGRLYREVGKLQFVDVAVAR 258
Cdd:PRK15030 191 EGALVqNGQATALATVQQLDPIYVDVTQSSNDFLRLKQEL-ANGTLKqengKAKVSLITSDGIKFPQDGTLEFSDVTVDQ 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 259 DTDSIILRGTIANPplaggGRELTHDEMVRVLL-EGSKPREVLaIPRAAILTDQQGD-YVYVVSDKNVAERRRVKLGQST 336
Cdd:PRK15030 270 TTGSITLRAIFPNP-----DHTLLPGMFVRARLeEGLNPNAIL-VPQQGVTRTPRGDaTVLVVGADDKVETRPIVASQAI 343
|
330 340
....*....|....*....|....*.
gi 1347339825 337 AQIASVIDGLKAGDQVIVEGVQRARP 362
Cdd:PRK15030 344 GDKWLVTEGLKAGDRVVISGLQKVRP 369
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
31-362 |
4.51e-45 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 159.50 E-value: 4.51e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 31 PAVGTITARPQAITETTEINGRIQAIGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEADAEAKRAAVDQAQA 110
Cdd:PRK09859 34 PEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQIDPAPLQAELNSAKGSLAKALS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 111 QLDYADLALGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRIGRIQVTLGNVVGP 190
Cdd:PRK09859 114 TASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYANVTSPITGVSGKSSVTVGALVTA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 191 S-SGALATVVSQDPAYVVFPISVNRLLQLREEFAAqGGLEAMK----IRLRLPDGRLYREVGKLQFVDVAVARDTDSIIL 265
Cdd:PRK09859 194 NqADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVAS-GQIKQVQgstpVQLNLENGKRYSQTGTLKFSDPTVDETTGSVTL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 266 RGTIANPplagGGRELTHDEMVRVLLEGSKpREVLAIPRAAILTDQQGDYVYVVSDK-NVAERRRVKLGQSTAQIASVID 344
Cdd:PRK09859 273 RAIFPNP----NGDLLPGMYVTALVDEGSR-QNVLLVPQEGVTHNAQGKATALILDKdDVVQLREIEASKAIGDQWVVTS 347
|
330
....*....|....*...
gi 1347339825 345 GLKAGDQVIVEGVQRARP 362
Cdd:PRK09859 348 GLQAGDRVIVSGLQRIRP 365
|
|
| PRK09578 |
PRK09578 |
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit; |
28-355 |
3.06e-39 |
|
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 169982 [Multi-domain] Cd Length: 385 Bit Score: 143.78 E-value: 3.06e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 28 GGPPAVGTITARPQAITETTEINGRIQAIGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEADAEAKRAAVDQ 107
Cdd:PRK09578 33 AAPREATVVTVRPTSVPMTVELPGRLDAYRQAEVRARVAGIVTARTYEEGQEVKQGAVLFRIDPAPLKAARDAAAGALAK 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 108 AQAQLDYADLALGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRIGRIQVTLGNV 187
Cdd:PRK09578 113 AEAAHLAALDKRRRYDDLVRDRAVSERDYTEAVADERQAKAAVASAKAELARAQLQLDYATVTAPIDGRARRALVTEGAL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 188 VGPSSGALATVVSQ-DPAYVVFPISVNRLLQLREEF-------AAQGGLEamkIRLRLPDGRLYREVGKLQFVDVAVARD 259
Cdd:PRK09578 193 VGQDQATPLTTVEQlDPIYVNFSQPAADVEALRRAVksgratgIAQQDVA---VTLVRADGSEYPLKGKLLFSDLAVDPT 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 260 TDSIILRGTIANPPlagggRELTHDEMVRVLLEGSKPREVLAIPRAAILTDQQGDYVYVVSDKNVAERRRVKLGQSTAQI 339
Cdd:PRK09578 270 TDTVAMRALFPNPE-----RELLPGAYVRIALDRAVNPRAILVPRDALLRTADSASVKVVGQNGKVRDVEVEADQMSGRD 344
|
330
....*....|....*.
gi 1347339825 340 ASVIDGLKAGDQVIVE 355
Cdd:PRK09578 345 WIVTRGLAGGERVIVD 360
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
40-354 |
4.96e-28 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 112.13 E-value: 4.96e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 40 PQAITETTEINGRIQAIGRVD-LTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEADAEAKRAAVDQAQAQLDYADLA 118
Cdd:pfam00529 1 LAPLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 119 LGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRIGRIQVTLGNVVGPSSGALATV 198
Cdd:pfam00529 81 LDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLAT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 199 VSQ-DPAYVVFPISVNRLLQLREEFAAQGGLEAM----KIRLRLPDGRLYREV----GKLQFVDVAVARDTDSIILRGTI 269
Cdd:pfam00529 161 VAQlDQIYVQITQSAAENQAEVRSELSGAQLQIAeaeaELKLAKLDLERTEIRapvdGTVAFLSVTVDGGTVSAGLRLMF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 270 ANPPlaggGRELTHDEMVRVLLEGSKPREVLAIPRAAILTDQQGDY-VYVVSDKNVAERRRVKLGQSTAQIASVIDGLKA 348
Cdd:pfam00529 241 VVPE----DNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFtGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSA 316
|
....*.
gi 1347339825 349 GDQVIV 354
Cdd:pfam00529 317 GALVRL 322
|
|
| PRK11556 |
PRK11556 |
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit; |
25-359 |
1.27e-27 |
|
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 183194 [Multi-domain] Cd Length: 415 Bit Score: 112.58 E-value: 1.27e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 25 MPGGGPPAVGTITARPQAITETTEINGRIQAIGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEAdaeakraA 104
Cdd:PRK11556 54 MRSGPLAPVQAATATEQAVPRYLTGLGTVTAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKV-------A 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 105 VDQAQAQL--DYADLA-----LGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRI 177
Cdd:PRK11556 127 LAQAQGQLakDQATLAnarrdLARYQQLAKTNLVSRQELDAQQALVSETEGTIKADEASVASAQLQLDYSRITAPISGRV 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 178 GRIQVTLGNVVGPSSGALATVVSQ-DPAYVVFPISVNRLLQLreefaaqggLEAMKIRLRLPDGRLYR------EVGKLQ 250
Cdd:PRK11556 207 GLKQVDVGNQISSGDTTGIVVITQtHPIDLVFTLPESDIATV---------VQAQKAGKPLVVEAWDRtnskklSEGTLL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 251 FVDVAVARDTDSIILRGTIANPPLAgggreLTHDEMVRVLLEGSKPREVLAIPRAAILTDQQGDYVYVVSDKNVAERRRV 330
Cdd:PRK11556 278 SLDNQIDATTGTIKLKARFNNQDDA-----LFPNQFVNARMLVDTLQNAVVIPTAALQMGNEGHFVWVLNDENKVSKHLV 352
|
330 340
....*....|....*....|....*....
gi 1347339825 331 KLGQSTAQIASVIDGLKAGDQVIVEGVQR 359
Cdd:PRK11556 353 TPGIQDSQKVVISAGLSAGDRVVTDGIDR 381
|
|
| EmrA |
COG1566 |
Multidrug resistance efflux pump EmrA [Defense mechanisms]; |
32-219 |
1.19e-22 |
|
Multidrug resistance efflux pump EmrA [Defense mechanisms];
Pssm-ID: 441174 [Multi-domain] Cd Length: 331 Bit Score: 97.43 E-value: 1.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 32 AVGTITARPQAITETTEINGRIQAiGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEAD---AEAK------- 101
Cdd:COG1566 20 GLALWAAGRNGPDEPVTADGRVEA-RVVTVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAAlaqAEAQlaaaeaq 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 102 -----------------RAAVDQAQAQLDYADLALGRAEQLLKTSSGSQSTADN-------------------------- 138
Cdd:COG1566 99 larleaelgaeaeiaaaEAQLAAAQAQLDLAQRELERYQALYKKGAVSQQELDEaraaldaaqaqleaaqaqlaqaqagl 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 139 -ARAAQRTAAAQLRSAQAQLRQSEINLGYTEIRSPIDGRIGRIQVTLGNVVGPSSgALATVVSQDPAYVVFPISVNRLLQ 217
Cdd:COG1566 179 rEEEELAAAQAQVAQAEAALAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQ-PLLTIVPLDDLWVEAYVPETDLGR 257
|
..
gi 1347339825 218 LR 219
Cdd:COG1566 258 VK 259
|
|
| PRK11578 |
PRK11578 |
macrolide transporter subunit MacA; Provisional |
31-354 |
1.92e-13 |
|
macrolide transporter subunit MacA; Provisional
Pssm-ID: 183211 [Multi-domain] Cd Length: 370 Bit Score: 70.96 E-value: 1.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 31 PAVGTITARPQAITETTEINGRIQAIGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPP-------FEADAEAKRA 103
Cdd:PRK11578 34 PTYQTLIVRPGDLQQSVLATGKLDALRKVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPEQaenqikeVEATLMELRA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 104 AVDQAQAQLDYADLALGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSE-------INLGYTEIRSPIDGR 176
Cdd:PRK11578 114 QRQQAEAELKLARVTLSRQQRLAKTQAVSQQDLDTAATELAVKQAQIGTIDAQIKRNQasldtakTNLDYTRIVAPMAGE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 177 IGRIQVTLGNVVGPSSGA--LATVVSQDPAYVVFPISVNRLLQLREefaaqgGLEAMKIRLRLPDGRLYrevGKLQFVDV 254
Cdd:PRK11578 194 VTQITTLQGQTVIAAQQApnILTLADMSTMLVKAQVSEADVIHLKP------GQKAWFTVLGDPLTRYE---GVLKDILP 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 255 AVARDTDSIIL--RGTIANPPlagGGRELTHDEMVRVLLEGSKprEVLAIPRAAiLTDQQGDYVYVVS--DKNVAERRRV 330
Cdd:PRK11578 265 TPEKVNDAIFYyaRFEVPNPN---GLLRLDMTAQVHIQLTDVK--NVLTIPLSA-LGDPVGDNRYKVKllRNGETREREV 338
|
330 340
....*....|....*....|....
gi 1347339825 331 KLGQSTAQIASVIDGLKAGDQVIV 354
Cdd:PRK11578 339 TIGARNDTDVEIVKGLEAGDEVII 362
|
|
| PRK03598 |
PRK03598 |
putative efflux pump membrane fusion protein; Provisional |
56-207 |
3.84e-11 |
|
putative efflux pump membrane fusion protein; Provisional
Pssm-ID: 235136 [Multi-domain] Cd Length: 331 Bit Score: 63.44 E-value: 3.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 56 IGRVDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFE---ADAEAK-----------------------RAAVDQAQ 109
Cdd:PRK03598 41 IRTVNLGFRVGGRLASLAVDEGDAVKAGQVLGELDAAPYEnalMQAKANvsvaqaqldlmlagyrdeeiaqaRAAVKQAQ 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 110 AQLDYADLALGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLR--------------------------QSEIN 163
Cdd:PRK03598 121 AAYDYAQNFYNRQQGLWKSRTISANDLENARSSRDQAQATLKSAQDKLSqyregnrpqdiaqakaslaqaqaalaQAELN 200
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1347339825 164 LGYTEIRSPIDGRIgriqvtLGNVVGPSSgalaTVVSQDPAYVV 207
Cdd:PRK03598 201 LQDTELIAPSDGTI------LTRAVEPGT----MLNAGSTVFTL 234
|
|
| PRK10559 |
PRK10559 |
p-hydroxybenzoic acid efflux pump subunit AaeA; |
80-206 |
5.58e-06 |
|
p-hydroxybenzoic acid efflux pump subunit AaeA;
Pssm-ID: 182548 [Multi-domain] Cd Length: 310 Bit Score: 47.81 E-value: 5.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 80 VKKGDLLFRLEQPPFeadaeakRAAVDQAQAQLDY--ADLALGRAE----QLLKTSSGSQSTADNARAAQRTAAAQLRSA 153
Cdd:PRK10559 69 VKKGQVLFTIDQPRY-------QKALAEAEADVAYyqVLAQEKRREagrrNRLGVQAMSREEIDQANNVLQTVLHQLAKA 141
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1347339825 154 QAQLRQSEINLGYTEIRSPIDGRIGRIQVTLGNVVGPSSGALAtVVSQDPAYV 206
Cdd:PRK10559 142 QATRDLAKLDLERTVIRAPADGWVTNLNVYTGEFITRGSTAVA-LVKQNSFYV 193
|
|
| PRK10476 |
PRK10476 |
multidrug transporter subunit MdtN; |
59-207 |
3.48e-05 |
|
multidrug transporter subunit MdtN;
Pssm-ID: 182488 [Multi-domain] Cd Length: 346 Bit Score: 45.40 E-value: 3.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 59 VDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFE---ADAEA------------------------------KRAAV 105
Cdd:PRK10476 49 VHVASEVGGRIVELAVTENQAVKKGDLLFRIDPRPYEltvAQAQAdlaladaqimttqrsvdaersnaasaneqvERARA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 106 DQAQA-------------------QLDYADLALGRAEQLLKTSSGSQSTADNARAAQRTAAAQLRSAQAQLRQSEINLGY 166
Cdd:PRK10476 129 NAKLAtrtlerlepllakgyvsaqQVDQARTAQRDAEVSLNQALLQAQAAAAAVGGVDALVAQRAAREAALAIAELHLED 208
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1347339825 167 TEIRSPIDGRIGRIQVTLGNVVGPSSgALATVVSQDPAYVV 207
Cdd:PRK10476 209 TTVRAPFDGRVVGLKVSVGEFAAPMQ-PIFTLIDTDHWYAI 248
|
|
| HlyD_3 |
pfam13437 |
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ... |
168-275 |
1.05e-04 |
|
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.
Pssm-ID: 433206 [Multi-domain] Cd Length: 104 Bit Score: 41.19 E-value: 1.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 168 EIRSPIDGRIGRIQVTLGNVVGPSSgALATVVSQDPAYVVFPISVNRLLQLREEfaaqggleaMKIRLRLPDGRLYREVG 247
Cdd:pfam13437 1 TIRAPVDGVVAELNVEEGQVVQAGD-PLATIVPPDRLLVEAFVPAADLGSLKKG---------QKVTLKLDPGSDYTLEG 70
|
90 100
....*....|....*....|....*...
gi 1347339825 248 KLQFVDVAVARDTDSIILRGTIANPPLA 275
Cdd:pfam13437 71 KVVRISPTVDPDTGVIPVRVSIENPKTP 98
|
|
| Biotin_lipoyl_2 |
pfam13533 |
Biotin-lipoyl like; |
59-112 |
1.59e-03 |
|
Biotin-lipoyl like;
Pssm-ID: 433286 Cd Length: 50 Bit Score: 36.27 E-value: 1.59e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1347339825 59 VDLTARVNAYLQEQLFVEGAEVKKGDLLFRLEQPPFEadaeakrAAVDQAQAQL 112
Cdd:pfam13533 3 VKIASPVSGKVVAVNVKEGQQVKKGDVLATLDSPELQ-------LQLQQAEAQL 49
|
|
| PRK15136 |
PRK15136 |
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA; |
102-198 |
8.54e-03 |
|
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA;
Pssm-ID: 185090 [Multi-domain] Cd Length: 390 Bit Score: 38.14 E-value: 8.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1347339825 102 RAAVDQAQAQLDYAdLALGRAEQ--LLKTSSGSQSTadnaraaqrtaaaqLRSAQAQLRQSEINLGYTEIRSPIDGRIGR 179
Cdd:PRK15136 164 RDAVASAQAQLDVA-IQQYNANQamILNTPLEDQPA--------------VQQAATEVRNAWLALQRTKIVSPMTGYVSR 228
|
90
....*....|....*....
gi 1347339825 180 IQVTLGNVVGPSSGALATV 198
Cdd:PRK15136 229 RSVQVGAQISPTTPLMAVV 247
|
|
| |
