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Conserved domains on  [gi|1345439630|gb|AVF26533|]
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iron-regulated protein D [Paenibacillus larvae subsp. larvae]

Protein Classification

NEAT and srtB_target domain-containing protein( domain architecture ID 13429811)

NEAT and srtB_target domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NEAT COG5386
Heme-binding NEAT domain [Inorganic ion transport and metabolism];
1-250 3.87e-44

Heme-binding NEAT domain [Inorganic ion transport and metabolism];


:

Pssm-ID: 444149 [Multi-domain]  Cd Length: 302  Bit Score: 156.22  E-value: 3.87e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630   1 MKTMKKYINGAVIFFFAFFTFLSSSYLQNVQAADSIKDGEYTIDFTVLKDKTEAASMMDTYAEKPAKLIVKNGNAKISHK 80
Cdd:COG5386     1 MKKVFDGMLSVLLAALLSVTFASVDVTEPTTAAATLADGTYSINFKVLKDGTDEASMMNQYFEKPAKLTVKNGKYYVTMT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  81 LAHSSWITQYQVEQNGSLKDTTILESDASEDKRVVEFEvgVGDTAKKINARVKVDIPGMNYHHAYDVQLAFKLDTLKPVQ 160
Cdd:COG5386    81 LNDSSWVTSFKVEVNGSFVDATVVSEDKAANTRVVEFE--VPDLSKPLNAKVHVVIPAINYDHKYDVRLVFDTNSIKPVG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 161 VKAEPAPVPTPEPTpavtpepapvptpkptpaatpepapvptpkptpipapvptpvptlvPAPILEDGTYTIDFTLYKDK 240
Cdd:COG5386   159 PVKEEPAPPPENTT----------------------------------------------DPEKLEDGTYTIDFKVLKDG 192

                         250
                  ....*....|
gi 1345439630 241 TQEVSKMDTY 250
Cdd:COG5386   193 TKEISMMDQT 202
NEAT COG5386
Heme-binding NEAT domain [Inorganic ion transport and metabolism];
225-421 2.79e-41

Heme-binding NEAT domain [Inorganic ion transport and metabolism];


:

Pssm-ID: 444149 [Multi-domain]  Cd Length: 302  Bit Score: 148.90  E-value: 2.79e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 225 LEDGTYTIDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETTILSLDGIADTRVV 304
Cdd:COG5386    36 LADGTYSINFKVLKDGTDEASMMNQYFEKPAKLTVKNGKYYVTMTLNDSSWVTSFKVEVNGSFVDATVVSEDKAANTRVV 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 305 QFDIADITETLNARVKVDIPEMNYHHTYDVQLAFDSDSIESVQGKPDPsrgPESKPEPKEAPASDPDGTLSTDATS---N 381
Cdd:COG5386   116 EFEVPDLSKPLNAKVHVVIPAINYDHKYDVRLVFDTNSIKPVGPVKEE---PAPPPENTTDPEKLEDGTYTIDFKVlkdG 192

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1345439630 382 SNTDALSFDRDSDKQTGASQKYKQPKENNPKTADTAQIGI 421
Cdd:COG5386   193 TKEISMMDQTRTVEFKNPKPSDNVTSTAANSGSLQAKEGI 232
Trypan_PARP super family cl42451
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 154-204 3.01e-09

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


The actual alignment was detected with superfamily member pfam05887:

Pssm-ID: 368653  Cd Length: 134  Bit Score: 55.18  E-value: 3.01e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1345439630 154 DTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:pfam05887  52 DDTNGTDPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPE 102
srtB_target TIGR03063
sortase B cell surface sorting signal; Two different classes of sorting signal, both analogous ...
 410-441 6.75e-06

sortase B cell surface sorting signal; Two different classes of sorting signal, both analogous to the sortase A signal LPXTG, may be recognized by the sortase SrtB. These are given as NXZTN and NPKXZ. Proteins sorted by this class of sortase are less common than the sortase A and LPXTG system. This model describes a number of cell surface protein C-terminal regions from Gram-positive bacteria that appear to be sortase B (SrtB) sorting signals.


:

Pssm-ID: 213766  Cd Length: 29  Bit Score: 42.58  E-value: 6.75e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1345439630 410 NPKTADTAQIGIYSSILVASLVVLtvkIWRWR 441
Cdd:TIGR03063   1 NPKTGDSAQIGLYAVLFLGSGLFL---IRKRK 29
 
Name Accession Description Interval E-value
NEAT COG5386
Heme-binding NEAT domain [Inorganic ion transport and metabolism];
1-250 3.87e-44

Heme-binding NEAT domain [Inorganic ion transport and metabolism];


Pssm-ID: 444149 [Multi-domain]  Cd Length: 302  Bit Score: 156.22  E-value: 3.87e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630   1 MKTMKKYINGAVIFFFAFFTFLSSSYLQNVQAADSIKDGEYTIDFTVLKDKTEAASMMDTYAEKPAKLIVKNGNAKISHK 80
Cdd:COG5386     1 MKKVFDGMLSVLLAALLSVTFASVDVTEPTTAAATLADGTYSINFKVLKDGTDEASMMNQYFEKPAKLTVKNGKYYVTMT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  81 LAHSSWITQYQVEQNGSLKDTTILESDASEDKRVVEFEvgVGDTAKKINARVKVDIPGMNYHHAYDVQLAFKLDTLKPVQ 160
Cdd:COG5386    81 LNDSSWVTSFKVEVNGSFVDATVVSEDKAANTRVVEFE--VPDLSKPLNAKVHVVIPAINYDHKYDVRLVFDTNSIKPVG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 161 VKAEPAPVPTPEPTpavtpepapvptpkptpaatpepapvptpkptpipapvptpvptlvPAPILEDGTYTIDFTLYKDK 240
Cdd:COG5386   159 PVKEEPAPPPENTT----------------------------------------------DPEKLEDGTYTIDFKVLKDG 192

                         250
                  ....*....|
gi 1345439630 241 TQEVSKMDTY 250
Cdd:COG5386   193 TKEISMMDQT 202
NEAT COG5386
Heme-binding NEAT domain [Inorganic ion transport and metabolism];
225-421 2.79e-41

Heme-binding NEAT domain [Inorganic ion transport and metabolism];


Pssm-ID: 444149 [Multi-domain]  Cd Length: 302  Bit Score: 148.90  E-value: 2.79e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 225 LEDGTYTIDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETTILSLDGIADTRVV 304
Cdd:COG5386    36 LADGTYSINFKVLKDGTDEASMMNQYFEKPAKLTVKNGKYYVTMTLNDSSWVTSFKVEVNGSFVDATVVSEDKAANTRVV 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 305 QFDIADITETLNARVKVDIPEMNYHHTYDVQLAFDSDSIESVQGKPDPsrgPESKPEPKEAPASDPDGTLSTDATS---N 381
Cdd:COG5386   116 EFEVPDLSKPLNAKVHVVIPAINYDHKYDVRLVFDTNSIKPVGPVKEE---PAPPPENTTDPEKLEDGTYTIDFKVlkdG 192

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1345439630 382 SNTDALSFDRDSDKQTGASQKYKQPKENNPKTADTAQIGI 421
Cdd:COG5386   193 TKEISMMDQTRTVEFKNPKPSDNVTSTAANSGSLQAKEGI 232
NEAT pfam05031
Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules ...
 225-339 8.57e-41

Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules highly conserved in secondary structure. They have roles in hemoprotein binding, heme extraction and heme transfer


Pssm-ID: 428269 [Multi-domain]  Cd Length: 116  Bit Score: 141.24  E-value: 8.57e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 225 LEDGTYTIDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETTILSLDGIADTRVV 304
Cdd:pfam05031   2 LADGTYTIDFKVLKDGTDEASMANGYLDKPAKLTVKNGKKYVTLTLNNSDWIKNFKVEVNGTLVDVEVVSEDTGKDTRTV 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1345439630 305 QFDIADITETLNARVKVDIPEMNYHHTYDVQLAFD 339
Cdd:pfam05031  82 RFEVPDLDKKLNAKVHVYVPMGNYDHKYDVQLQFD 116
NEAT pfam05031
Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules ...
 36-152 2.41e-39

Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules highly conserved in secondary structure. They have roles in hemoprotein binding, heme extraction and heme transfer


Pssm-ID: 428269 [Multi-domain]  Cd Length: 116  Bit Score: 137.39  E-value: 2.41e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  36 IKDGEYTIDFTVLKDKTEAASMMDTYAEKPAKLIVKNGNAKISHKLAHSSWITQYQVEQNGSLKDTTILESDASEDKRVV 115
Cdd:pfam05031   2 LADGTYTIDFKVLKDGTDEASMANGYLDKPAKLTVKNGKKYVTLTLNNSDWIKNFKVEVNGTLVDVEVVSEDTGKDTRTV 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1345439630 116 EFEvgVGDTAKKINARVKVDIPGMNYHHAYDVQLAFK 152
Cdd:pfam05031  82 RFE--VPDLDKKLNAKVHVYVPMGNYDHKYDVQLQFD 116
NEAT cd06920
NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; ...
 227-343 2.32e-36

NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; used by pathogenic bacteria to to scavenge heme-iron from host hemoproteins. The NEAT domain is a component of cell surface proteins (iron regulated surface determinants, or Isd, such as IsdA and IsdC) in various gram-positive bacteria, and may be arranged in tandem repeats.


Pssm-ID: 132993 [Multi-domain]  Cd Length: 117  Bit Score: 129.74  E-value: 2.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 227 DGTYTIDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETTILSLDGIADTRVVQF 306
Cdd:cd06920     1 DGTYTVNFKVLKEGTDEPSMANGYLNKPAKLTVKNGKKYVTLTLKNSDWMKNFKVEVNGGNKDVVVVKDDNSNNTRTVKF 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1345439630 307 DIADITETLNARVKVDIPEMNYHHTYDVQLAFDSDSI 343
Cdd:cd06920    81 EVPDLDSKINAKVHVVVMGINYDHKYDVRLKFDTSSI 117
IsdC TIGR03656
heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, ...
 225-440 2.73e-36

heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins. The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, pfam05031) domain, which confers the ability to bind heme, and a C-terminal SrtB processing signal which targets the protein to the cell wall. IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall.


Pssm-ID: 274705 [Multi-domain]  Cd Length: 217  Bit Score: 132.72  E-value: 2.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 225 LEDGTYTIDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGslkeTTILSLDGIADTRVV 304
Cdd:TIGR03656  29 LADGTYTINYTVYKADNDSASMANDYFEKPAKLIVKNGKMTVQITVNHSHWITGFKVEGNG----VNVVSKNEAADKRTV 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 305 QFDIADITETLNARVKVDIPE-MNYHHTYDVQLAFDSDSieSVQGKPDPSRGPESKPEPKEAPAsdpDGTlSTDATSNSN 383
Cdd:TIGR03656 105 EFPVSDLSGPIDGKIHVYVDDkVNYDHHYTIRLKFDGPT--SVAGANAAGKDDKNSAEGSDKGS---NGT-TTKQSKSES 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1345439630 384 TDAlsfdrdsdkqtgasqkykqPKENNPKTADTAQIGIYSSILVASLVVLTVKIWRW 440
Cdd:TIGR03656 179 SNK-------------------DKVDNPQTGDGTPIYLYAIALLIAGALLIRKKSKG 216
NEAT cd06920
NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; ...
 38-156 7.23e-36

NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; used by pathogenic bacteria to to scavenge heme-iron from host hemoproteins. The NEAT domain is a component of cell surface proteins (iron regulated surface determinants, or Isd, such as IsdA and IsdC) in various gram-positive bacteria, and may be arranged in tandem repeats.


Pssm-ID: 132993 [Multi-domain]  Cd Length: 117  Bit Score: 128.20  E-value: 7.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  38 DGEYTIDFTVLKDKTEAASMMDTYAEKPAKLIVKNGNAKISHKLAHSSWITQYQVEQNGSLKDTTILESDASEDKRVVEF 117
Cdd:cd06920     1 DGTYTVNFKVLKEGTDEPSMANGYLNKPAKLTVKNGKKYVTLTLKNSDWMKNFKVEVNGGNKDVVVVKDDNSNNTRTVKF 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1345439630 118 EvgVGDTAKKINARVKVDIPGMNYHHAYDVQLAFKLDTL 156
Cdd:cd06920    81 E--VPDLDSKINAKVHVVVMGINYDHKYDVRLKFDTSSI 117
NEAT smart00725
NEAr Transporter domain;
37-158 2.12e-30

NEAr Transporter domain;


Pssm-ID: 214790 [Multi-domain]  Cd Length: 123  Bit Score: 113.98  E-value: 2.12e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630   37 KDGEYTIDFTVLKDKTEAASMMDTYAEKPAKLIVKNGNAKISHKLAHSSWITQYQVEQNGSLKDTTILESDASEDKRVVE 116
Cdd:smart00725   1 ADGIYTINFVVLKDNSNEESMMDDYVNKPAKLIVKNGKTYVTLTLNNSSFWKDFEVEVNGTKVDVEVVSKDKDNDTRTIR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1345439630  117 FEVGVGDTakKINARVKVDIPGM---NYHHAYDVQLAFKLDTLKP 158
Cdd:smart00725  81 FPVPNLDA--DLDAKVHVVVPEIgveNYDHDYTVQLIFDEASTKA 123
NEAT smart00725
NEAr Transporter domain;
226-343 1.32e-29

NEAr Transporter domain;


Pssm-ID: 214790 [Multi-domain]  Cd Length: 123  Bit Score: 111.67  E-value: 1.32e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  226 EDGTYTIDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETTILSLDGIADTRVVQ 305
Cdd:smart00725   1 ADGIYTINFVVLKDNSNEESMMDDYVNKPAKLIVKNGKTYVTLTLNNSSFWKDFEVEVNGTKVDVEVVSKDKDNDTRTIR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1345439630  306 FDIADITETLNARVKVDIPEM---NYHHTYDVQLAFDSDSI 343
Cdd:smart00725  81 FPVPNLDADLDAKVHVVVPEIgveNYDHDYTVQLIFDEAST 121
IsdC TIGR03656
heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, ...
 32-204 6.65e-28

heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins. The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, pfam05031) domain, which confers the ability to bind heme, and a C-terminal SrtB processing signal which targets the protein to the cell wall. IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall.


Pssm-ID: 274705 [Multi-domain]  Cd Length: 217  Bit Score: 109.99  E-value: 6.65e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  32 AADSIKDGEYTIDFTVLKDKTEAASMMDTYAEKPAKLIVKNGNAKISHKLAHSSWITQYQVEQNGslkdTTILESDASED 111
Cdd:TIGR03656  25 NSANLADGTYTINYTVYKADNDSASMANDYFEKPAKLIVKNGKMTVQITVNHSHWITGFKVEGNG----VNVVSKNEAAD 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 112 KRVVEFEvgVGDTAKKINARVKVDIP-GMNYHHAYDVQLAFKldtlKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPT 190
Cdd:TIGR03656 101 KRTVEFP--VSDLSGPIDGKIHVYVDdKVNYDHHYTIRLKFD----GPTSVAGANAAGKDDKNSAEGSDKGSNGTTTKQS 174

                         170
                  ....*....|....
gi 1345439630 191 PAATPEPAPVPTPK 204
Cdd:TIGR03656 175 KSESSNKDKVDNPQ 188
Trypan_PARP pfam05887
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 154-204 3.01e-09

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


Pssm-ID: 368653  Cd Length: 134  Bit Score: 55.18  E-value: 3.01e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1345439630 154 DTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:pfam05887  52 DDTNGTDPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPE 102
PRK10819 PRK10819
transport protein TonB; Provisional
 158-204 6.82e-08

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 53.15  E-value: 6.82e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVTPEP---APVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK10819   61 PQAVQPPPEPVVEPEPEPEPIPEPpkeAPVVIPKPEPKPKPKPKPKPKPV 110
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
144-204 6.96e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 54.67  E-value: 6.96e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1345439630 144 AYDVQLAFKLDTLKPVQVKAEPAPVpTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK14960  386 AQTAQEITPVSAVQPVEVISQPAMV-EPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPQPN 445
MSCRAMM_ClfB NF033845
MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial ...
 164-397 5.97e-07

MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468203 [Multi-domain]  Cd Length: 871  Bit Score: 51.87  E-value: 5.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 164 EPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAPILEDGTYTIDFTLYKDKTQE 243
Cdd:NF033845  545 DPTPGPPVDPEPSPEPEPEPTPDPEPSPDPDPEPSPDPDPDSDSDSDSGSDSDSGSDSDSDSDSDSDSDSDSDSDSDSDS 624

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 244 VSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETtilslDGIADTRVVQFDIADITETLNARVKVDI 323
Cdd:NF033845  625 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDDSDSDS-----DSDSDSDSDSDSDSDSDSDSDSDSDSDS 699

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1345439630 324 PEMNYHHTYDVQLAFDSDSIESVQGKPDPSRGPESKPEPKEAPASDPDGTLSTDATSNSNTDALSfDRDSDKQT 397
Cdd:NF033845  700 DSSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDS 772
srtB_target TIGR03063
sortase B cell surface sorting signal; Two different classes of sorting signal, both analogous ...
 410-441 6.75e-06

sortase B cell surface sorting signal; Two different classes of sorting signal, both analogous to the sortase A signal LPXTG, may be recognized by the sortase SrtB. These are given as NXZTN and NPKXZ. Proteins sorted by this class of sortase are less common than the sortase A and LPXTG system. This model describes a number of cell surface protein C-terminal regions from Gram-positive bacteria that appear to be sortase B (SrtB) sorting signals.


Pssm-ID: 213766  Cd Length: 29  Bit Score: 42.58  E-value: 6.75e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1345439630 410 NPKTADTAQIGIYSSILVASLVVLtvkIWRWR 441
Cdd:TIGR03063   1 NPKTGDSAQIGLYAVLFLGSGLFL---IRKRK 29
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 152-223 3.99e-05

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 45.61  E-value: 3.99e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1345439630 152 KLDTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAP 223
Cdd:COG3266   269 TTSLGEQQEVSLPPAVAAQPAAAAAAQPSAVALPAAPAAAAAAAAPAEAAAPQPTAAKPVVTETAAPAAPAP 340
MSCRAMM_ClfB NF033845
MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial ...
 161-414 1.61e-04

MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468203 [Multi-domain]  Cd Length: 871  Bit Score: 44.17  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 161 VKAEPAPVPTPEPTPavTPEPAPVPTPKPTPAATPEP---------APVPTPKPTPIPAPVPTPVPTLVPAPILEDGTYT 231
Cdd:NF033845  552 VDPEPSPEPEPEPTP--DPEPSPDPDPEPSPDPDPDSdsdsdsgsdSDSGSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 629

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 232 IDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETTILSLDGIADTRVVQFDIADI 311
Cdd:NF033845  630 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSSDSDSDSD 709

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 312 TETLNARVKVDIPEMNYHHTYDVQLAFDSDSIESVQGKPDPSRGPESKPEPKEAPASDPDGTLSTDATSNSNTDALSfDR 391
Cdd:NF033845  710 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DS 788

                         250       260
                  ....*....|....*....|...
gi 1345439630 392 DSDKQTGASQKYKQPkeNNPKTA 414
Cdd:NF033845  789 DSDSDSDSDSRVTPP--NNEQKA 809
internalin_K NF033186
class 1 internalin InlK; Internalins, as found in the intracellular human pathogen Listeria ...
 52-203 1.19e-03

class 1 internalin InlK; Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.


Pssm-ID: 467984 [Multi-domain]  Cd Length: 604  Bit Score: 41.22  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  52 TEAASMMDTYAEKPAKLIVKNGNA-KISHKLAHSSWITqYQVEQNGSLK------DTTILESDASEDKRVVEFEVGVGDT 124
Cdd:NF033186  371 TEAEFLADIHAKTDDGSTVTSDFAdKVDFKTPGTYTVT-LQSENNSGLKaapvqvNVTIKEKTAITADEKITYKVDTSKT 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 125 AKKINARVKVDipgMNYHHAYDVQLAFKLDTLKP----VQVKAE---PAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEP 197
Cdd:NF033186  450 EAEFLADIKAK---TNDGTAITSDFATVVDLSKPgkyvVTLNAEndlQKALPVQVTVIVEKETPIPDPTPDPTPDPTPTP 526


                  ....*.
gi 1345439630 198 APVPTP 203
Cdd:NF033186  527 DPTPTP 532
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 158-220 1.63e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 1.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKP-TPAATPEPAPVPTPKPTPIPAPVPTPVPTLV 220
Cdd:TIGR00601  88 AATPTSAPTPTPSPPASPASGMSAAPASAVEEkSPSEESATATAPESPSTSVPSSGSDAASTLV 151
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 149-203 1.75e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 40.76  E-value: 1.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1345439630 149 LAFKLDTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:NF041121   11 LAAQMGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAP 65
 
Name Accession Description Interval E-value
NEAT COG5386
Heme-binding NEAT domain [Inorganic ion transport and metabolism];
1-250 3.87e-44

Heme-binding NEAT domain [Inorganic ion transport and metabolism];


Pssm-ID: 444149 [Multi-domain]  Cd Length: 302  Bit Score: 156.22  E-value: 3.87e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630   1 MKTMKKYINGAVIFFFAFFTFLSSSYLQNVQAADSIKDGEYTIDFTVLKDKTEAASMMDTYAEKPAKLIVKNGNAKISHK 80
Cdd:COG5386     1 MKKVFDGMLSVLLAALLSVTFASVDVTEPTTAAATLADGTYSINFKVLKDGTDEASMMNQYFEKPAKLTVKNGKYYVTMT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  81 LAHSSWITQYQVEQNGSLKDTTILESDASEDKRVVEFEvgVGDTAKKINARVKVDIPGMNYHHAYDVQLAFKLDTLKPVQ 160
Cdd:COG5386    81 LNDSSWVTSFKVEVNGSFVDATVVSEDKAANTRVVEFE--VPDLSKPLNAKVHVVIPAINYDHKYDVRLVFDTNSIKPVG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 161 VKAEPAPVPTPEPTpavtpepapvptpkptpaatpepapvptpkptpipapvptpvptlvPAPILEDGTYTIDFTLYKDK 240
Cdd:COG5386   159 PVKEEPAPPPENTT----------------------------------------------DPEKLEDGTYTIDFKVLKDG 192

                         250
                  ....*....|
gi 1345439630 241 TQEVSKMDTY 250
Cdd:COG5386   193 TKEISMMDQT 202
NEAT COG5386
Heme-binding NEAT domain [Inorganic ion transport and metabolism];
225-421 2.79e-41

Heme-binding NEAT domain [Inorganic ion transport and metabolism];


Pssm-ID: 444149 [Multi-domain]  Cd Length: 302  Bit Score: 148.90  E-value: 2.79e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 225 LEDGTYTIDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETTILSLDGIADTRVV 304
Cdd:COG5386    36 LADGTYSINFKVLKDGTDEASMMNQYFEKPAKLTVKNGKYYVTMTLNDSSWVTSFKVEVNGSFVDATVVSEDKAANTRVV 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 305 QFDIADITETLNARVKVDIPEMNYHHTYDVQLAFDSDSIESVQGKPDPsrgPESKPEPKEAPASDPDGTLSTDATS---N 381
Cdd:COG5386   116 EFEVPDLSKPLNAKVHVVIPAINYDHKYDVRLVFDTNSIKPVGPVKEE---PAPPPENTTDPEKLEDGTYTIDFKVlkdG 192

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1345439630 382 SNTDALSFDRDSDKQTGASQKYKQPKENNPKTADTAQIGI 421
Cdd:COG5386   193 TKEISMMDQTRTVEFKNPKPSDNVTSTAANSGSLQAKEGI 232
NEAT pfam05031
Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules ...
 225-339 8.57e-41

Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules highly conserved in secondary structure. They have roles in hemoprotein binding, heme extraction and heme transfer


Pssm-ID: 428269 [Multi-domain]  Cd Length: 116  Bit Score: 141.24  E-value: 8.57e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 225 LEDGTYTIDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETTILSLDGIADTRVV 304
Cdd:pfam05031   2 LADGTYTIDFKVLKDGTDEASMANGYLDKPAKLTVKNGKKYVTLTLNNSDWIKNFKVEVNGTLVDVEVVSEDTGKDTRTV 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1345439630 305 QFDIADITETLNARVKVDIPEMNYHHTYDVQLAFD 339
Cdd:pfam05031  82 RFEVPDLDKKLNAKVHVYVPMGNYDHKYDVQLQFD 116
NEAT pfam05031
Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules ...
 36-152 2.41e-39

Iron Transport-associated domain; NEAT domains are heme and/or hemoprotein-binding modules highly conserved in secondary structure. They have roles in hemoprotein binding, heme extraction and heme transfer


Pssm-ID: 428269 [Multi-domain]  Cd Length: 116  Bit Score: 137.39  E-value: 2.41e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  36 IKDGEYTIDFTVLKDKTEAASMMDTYAEKPAKLIVKNGNAKISHKLAHSSWITQYQVEQNGSLKDTTILESDASEDKRVV 115
Cdd:pfam05031   2 LADGTYTIDFKVLKDGTDEASMANGYLDKPAKLTVKNGKKYVTLTLNNSDWIKNFKVEVNGTLVDVEVVSEDTGKDTRTV 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1345439630 116 EFEvgVGDTAKKINARVKVDIPGMNYHHAYDVQLAFK 152
Cdd:pfam05031  82 RFE--VPDLDKKLNAKVHVYVPMGNYDHKYDVQLQFD 116
NEAT cd06920
NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; ...
 227-343 2.32e-36

NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; used by pathogenic bacteria to to scavenge heme-iron from host hemoproteins. The NEAT domain is a component of cell surface proteins (iron regulated surface determinants, or Isd, such as IsdA and IsdC) in various gram-positive bacteria, and may be arranged in tandem repeats.


Pssm-ID: 132993 [Multi-domain]  Cd Length: 117  Bit Score: 129.74  E-value: 2.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 227 DGTYTIDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETTILSLDGIADTRVVQF 306
Cdd:cd06920     1 DGTYTVNFKVLKEGTDEPSMANGYLNKPAKLTVKNGKKYVTLTLKNSDWMKNFKVEVNGGNKDVVVVKDDNSNNTRTVKF 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1345439630 307 DIADITETLNARVKVDIPEMNYHHTYDVQLAFDSDSI 343
Cdd:cd06920    81 EVPDLDSKINAKVHVVVMGINYDHKYDVRLKFDTSSI 117
IsdC TIGR03656
heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, ...
 225-440 2.73e-36

heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins. The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, pfam05031) domain, which confers the ability to bind heme, and a C-terminal SrtB processing signal which targets the protein to the cell wall. IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall.


Pssm-ID: 274705 [Multi-domain]  Cd Length: 217  Bit Score: 132.72  E-value: 2.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 225 LEDGTYTIDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGslkeTTILSLDGIADTRVV 304
Cdd:TIGR03656  29 LADGTYTINYTVYKADNDSASMANDYFEKPAKLIVKNGKMTVQITVNHSHWITGFKVEGNG----VNVVSKNEAADKRTV 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 305 QFDIADITETLNARVKVDIPE-MNYHHTYDVQLAFDSDSieSVQGKPDPSRGPESKPEPKEAPAsdpDGTlSTDATSNSN 383
Cdd:TIGR03656 105 EFPVSDLSGPIDGKIHVYVDDkVNYDHHYTIRLKFDGPT--SVAGANAAGKDDKNSAEGSDKGS---NGT-TTKQSKSES 178

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1345439630 384 TDAlsfdrdsdkqtgasqkykqPKENNPKTADTAQIGIYSSILVASLVVLTVKIWRW 440
Cdd:TIGR03656 179 SNK-------------------DKVDNPQTGDGTPIYLYAIALLIAGALLIRKKSKG 216
NEAT cd06920
NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; ...
 38-156 7.23e-36

NEAr Transport domain, a component of cell surface proteins; NEAr Transporter (NEAT) domain; used by pathogenic bacteria to to scavenge heme-iron from host hemoproteins. The NEAT domain is a component of cell surface proteins (iron regulated surface determinants, or Isd, such as IsdA and IsdC) in various gram-positive bacteria, and may be arranged in tandem repeats.


Pssm-ID: 132993 [Multi-domain]  Cd Length: 117  Bit Score: 128.20  E-value: 7.23e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  38 DGEYTIDFTVLKDKTEAASMMDTYAEKPAKLIVKNGNAKISHKLAHSSWITQYQVEQNGSLKDTTILESDASEDKRVVEF 117
Cdd:cd06920     1 DGTYTVNFKVLKEGTDEPSMANGYLNKPAKLTVKNGKKYVTLTLKNSDWMKNFKVEVNGGNKDVVVVKDDNSNNTRTVKF 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1345439630 118 EvgVGDTAKKINARVKVDIPGMNYHHAYDVQLAFKLDTL 156
Cdd:cd06920    81 E--VPDLDSKINAKVHVVVMGINYDHKYDVRLKFDTSSI 117
NEAT smart00725
NEAr Transporter domain;
37-158 2.12e-30

NEAr Transporter domain;


Pssm-ID: 214790 [Multi-domain]  Cd Length: 123  Bit Score: 113.98  E-value: 2.12e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630   37 KDGEYTIDFTVLKDKTEAASMMDTYAEKPAKLIVKNGNAKISHKLAHSSWITQYQVEQNGSLKDTTILESDASEDKRVVE 116
Cdd:smart00725   1 ADGIYTINFVVLKDNSNEESMMDDYVNKPAKLIVKNGKTYVTLTLNNSSFWKDFEVEVNGTKVDVEVVSKDKDNDTRTIR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1345439630  117 FEVGVGDTakKINARVKVDIPGM---NYHHAYDVQLAFKLDTLKP 158
Cdd:smart00725  81 FPVPNLDA--DLDAKVHVVVPEIgveNYDHDYTVQLIFDEASTKA 123
NEAT smart00725
NEAr Transporter domain;
226-343 1.32e-29

NEAr Transporter domain;


Pssm-ID: 214790 [Multi-domain]  Cd Length: 123  Bit Score: 111.67  E-value: 1.32e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  226 EDGTYTIDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETTILSLDGIADTRVVQ 305
Cdd:smart00725   1 ADGIYTINFVVLKDNSNEESMMDDYVNKPAKLIVKNGKTYVTLTLNNSSFWKDFEVEVNGTKVDVEVVSKDKDNDTRTIR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1345439630  306 FDIADITETLNARVKVDIPEM---NYHHTYDVQLAFDSDSI 343
Cdd:smart00725  81 FPVPNLDADLDAKVHVVVPEIgveNYDHDYTVQLIFDEAST 121
IsdC TIGR03656
heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, ...
 32-204 6.65e-28

heme uptake protein IsdC; Isd proteins are iron-regulated surface proteins found in Bacillus, Staphylococcus and Listeria species and are responsible for heme scavenging from hemoproteins. The IsdC protein consists of an N-terminal hydrophobic signal sequence, a central NEAT (NEAr Transporter, pfam05031) domain, which confers the ability to bind heme, and a C-terminal SrtB processing signal which targets the protein to the cell wall. IsdC is believed to make a direct contact with, and transfer heme to, the heme-binding component (IsdE) of an ABC transporter in the cytoplasmic membrane, and to receive heme from other NEAT-containing heme-binding proteins also localized in the cell wall.


Pssm-ID: 274705 [Multi-domain]  Cd Length: 217  Bit Score: 109.99  E-value: 6.65e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  32 AADSIKDGEYTIDFTVLKDKTEAASMMDTYAEKPAKLIVKNGNAKISHKLAHSSWITQYQVEQNGslkdTTILESDASED 111
Cdd:TIGR03656  25 NSANLADGTYTINYTVYKADNDSASMANDYFEKPAKLIVKNGKMTVQITVNHSHWITGFKVEGNG----VNVVSKNEAAD 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 112 KRVVEFEvgVGDTAKKINARVKVDIP-GMNYHHAYDVQLAFKldtlKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPT 190
Cdd:TIGR03656 101 KRTVEFP--VSDLSGPIDGKIHVYVDdKVNYDHHYTIRLKFD----GPTSVAGANAAGKDDKNSAEGSDKGSNGTTTKQS 174

                         170
                  ....*....|....
gi 1345439630 191 PAATPEPAPVPTPK 204
Cdd:TIGR03656 175 KSESSNKDKVDNPQ 188
Trypan_PARP pfam05887
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 154-204 3.01e-09

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


Pssm-ID: 368653  Cd Length: 134  Bit Score: 55.18  E-value: 3.01e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1345439630 154 DTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:pfam05887  52 DDTNGTDPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPE 102
PRK10819 PRK10819
transport protein TonB; Provisional
 158-204 6.82e-08

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 53.15  E-value: 6.82e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVTPEP---APVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK10819   61 PQAVQPPPEPVVEPEPEPEPIPEPpkeAPVVIPKPEPKPKPKPKPKPKPV 110
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
144-204 6.96e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 54.67  E-value: 6.96e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1345439630 144 AYDVQLAFKLDTLKPVQVKAEPAPVpTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK14960  386 AQTAQEITPVSAVQPVEVISQPAMV-EPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPQPN 445
PRK11633 PRK11633
cell division protein DedD; Provisional
 155-204 1.22e-07

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 52.31  E-value: 1.22e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1345439630 155 TLKPVQVKAEPAPVPtPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK11633   84 SLDPATVAPPNTPVE-PEPAPVEPPKPKPVEKPKPKPKPQQKVEAPPAPK 132
MSCRAMM_ClfB NF033845
MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial ...
 164-397 5.97e-07

MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468203 [Multi-domain]  Cd Length: 871  Bit Score: 51.87  E-value: 5.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 164 EPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAPILEDGTYTIDFTLYKDKTQE 243
Cdd:NF033845  545 DPTPGPPVDPEPSPEPEPEPTPDPEPSPDPDPEPSPDPDPDSDSDSDSGSDSDSGSDSDSDSDSDSDSDSDSDSDSDSDS 624

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 244 VSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETtilslDGIADTRVVQFDIADITETLNARVKVDI 323
Cdd:NF033845  625 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDDSDSDS-----DSDSDSDSDSDSDSDSDSDSDSDSDSDS 699

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1345439630 324 PEMNYHHTYDVQLAFDSDSIESVQGKPDPSRGPESKPEPKEAPASDPDGTLSTDATSNSNTDALSfDRDSDKQT 397
Cdd:NF033845  700 DSSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDS 772
PRK11633 PRK11633
cell division protein DedD; Provisional
 158-204 8.03e-07

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 50.00  E-value: 8.03e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVTPEPAP--------VPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK11633   94 NTPVEPEPAPVEPPKPKPVEKPKPKPkpqqkveaPPAPKPEPKPVVEEKAAPTGK 148
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 166-201 2.99e-06

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 46.78  E-value: 2.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1345439630 166 APVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVP 201
Cdd:PRK05641   46 SAVQEQVPTPAPAPAPAVPSAPTPVAPAAPAPAPAS 81
Trypan_PARP pfam05887
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 157-204 4.25e-06

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


Pssm-ID: 368653  Cd Length: 134  Bit Score: 45.94  E-value: 4.25e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1345439630 157 KPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:pfam05887  45 KGTKVSDDDTNGTDPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPE 92
PRK11633 PRK11633
cell division protein DedD; Provisional
 161-229 5.69e-06

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 47.30  E-value: 5.69e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1345439630 161 VKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAPILEDGT 229
Cdd:PRK11633   75 VRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAPPAPKPEPKPVVEEKA 143
srtB_target TIGR03063
sortase B cell surface sorting signal; Two different classes of sorting signal, both analogous ...
 410-441 6.75e-06

sortase B cell surface sorting signal; Two different classes of sorting signal, both analogous to the sortase A signal LPXTG, may be recognized by the sortase SrtB. These are given as NXZTN and NPKXZ. Proteins sorted by this class of sortase are less common than the sortase A and LPXTG system. This model describes a number of cell surface protein C-terminal regions from Gram-positive bacteria that appear to be sortase B (SrtB) sorting signals.


Pssm-ID: 213766  Cd Length: 29  Bit Score: 42.58  E-value: 6.75e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1345439630 410 NPKTADTAQIGIYSSILVASLVVLtvkIWRWR 441
Cdd:TIGR03063   1 NPKTGDSAQIGLYAVLFLGSGLFL---IRKRK 29
PHA03247 PHA03247
large tegument protein UL36; Provisional
 158-203 8.32e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 8.32e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1345439630  158 PVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:PHA03247  2890 AVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP 2935
PRK10819 PRK10819
transport protein TonB; Provisional
 164-204 1.32e-05

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 46.21  E-value: 1.32e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1345439630 164 EPAPVPTPEPTPAVTPEPAPVPTPKPTPAA-----TPEPAPVPTPK 204
Cdd:PRK10819   59 EPPQAVQPPPEPVVEPEPEPEPIPEPPKEApvvipKPEPKPKPKPK 104
PHA03247 PHA03247
large tegument protein UL36; Provisional
 156-203 2.48e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 2.48e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1345439630  156 LKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:PHA03247  2900 LPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947
Trypan_PARP pfam05887
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 164-201 3.77e-05

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


Pssm-ID: 368653  Cd Length: 134  Bit Score: 43.24  E-value: 3.77e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1345439630 164 EPAPVPTPEPTPAVTPEPAPVPTPKPTP-AATPEPAPVP 201
Cdd:pfam05887  84 EPEPEPEPEPEPEPEPEPEPEPEPEPEPgAATLKSVALP 122
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 152-223 3.99e-05

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 45.61  E-value: 3.99e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1345439630 152 KLDTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAP 223
Cdd:COG3266   269 TTSLGEQQEVSLPPAVAAQPAAAAAAQPSAVALPAAPAAAAAAAAPAEAAAPQPTAAKPVVTETAAPAAPAP 340
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 158-203 4.34e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 46.04  E-value: 4.34e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1345439630  158 PVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:PRK12270    63 AAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAP 108
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 149-203 5.10e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.48  E-value: 5.10e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1345439630 149 LAFK---LDTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTP-AATPEPAPVPTP 203
Cdd:PRK14951  362 LAFKpaaAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPaAAASAPAAPPAA 420
PHA03247 PHA03247
large tegument protein UL36; Provisional
 158-203 5.23e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 5.23e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1345439630  158 PVQVKAEPAPVPTPEPTPAVTPEPAPVPTP----KPTPAATPEPAPVPTP 203
Cdd:PHA03247  2882 PVRRLARPAVSRSTESFALPPDQPERPPQPqappPPQPQPQPPPPPQPQP 2931
PRK09752 PRK09752
AIDA-I family autotransporter YfaL;
165-195 6.17e-05

AIDA-I family autotransporter YfaL;


Pssm-ID: 182059 [Multi-domain]  Cd Length: 1250  Bit Score: 45.43  E-value: 6.17e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1345439630  165 PAPVPTPEPTPavTPEPAPVPTPKPTPAATP 195
Cdd:PRK09752   924 PDPDPTPDPDP--TPDPDPTPDPEPTPAYQP 952
PRK12757 PRK12757
cell division protein FtsN; Provisional
 157-204 6.43e-05

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 44.26  E-value: 6.43e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1345439630 157 KPVQVKAEPAPVPTPEPT--PAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK12757  129 QPPATTAQPQPVTPPRQTtaPVQPQTPAPVRTQPAAPVTQAVEAPKVEAE 178
PRK11633 PRK11633
cell division protein DedD; Provisional
 164-223 9.49e-05

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 43.45  E-value: 9.49e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 164 EPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAP 223
Cdd:PRK11633   86 DPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAPPAPKPEPKPVVEEKAAP 145
PHA03247 PHA03247
large tegument protein UL36; Provisional
 163-223 1.03e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.03e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1345439630  163 AEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAP 223
Cdd:PHA03247   406 RPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDP 466
PHA03247 PHA03247
large tegument protein UL36; Provisional
 154-204 1.20e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 1.20e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1345439630  154 DTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PHA03247   403 DQTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQ 453
MSCRAMM_ClfB NF033845
MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial ...
 161-414 1.61e-04

MSCRAMM family adhesin clumping factor ClfB; Clumping factor B is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468203 [Multi-domain]  Cd Length: 871  Bit Score: 44.17  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 161 VKAEPAPVPTPEPTPavTPEPAPVPTPKPTPAATPEP---------APVPTPKPTPIPAPVPTPVPTLVPAPILEDGTYT 231
Cdd:NF033845  552 VDPEPSPEPEPEPTP--DPEPSPDPDPEPSPDPDPDSdsdsdsgsdSDSGSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 629

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 232 IDFTLYKDKTQEVSKMDTYTIKPAALTVNNGKMKISHTLTHSSWITQYEIEQNGSLKETTILSLDGIADTRVVQFDIADI 311
Cdd:NF033845  630 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSSDSDSDSD 709

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 312 TETLNARVKVDIPEMNYHHTYDVQLAFDSDSIESVQGKPDPSRGPESKPEPKEAPASDPDGTLSTDATSNSNTDALSfDR 391
Cdd:NF033845  710 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS-DS 788

                         250       260
                  ....*....|....*....|...
gi 1345439630 392 DSDKQTGASQKYKQPkeNNPKTA 414
Cdd:NF033845  789 DSDSDSDSDSRVTPP--NNEQKA 809
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 165-203 2.01e-04

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 44.11  E-value: 2.01e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1345439630  165 PAPVPTPEPTPA---VTPEPAPVPTPKPTPAATP-----EPAPVPTP 203
Cdd:pfam15324  966 EPPVAASVPGDLptkETLLPTPVPTPQPTPPCSPpsplkEPSPVKTP 1012
TonB_N pfam16031
TonB polyproline region; TonB from Escherichia coli and its homologs are critical for the ...
 159-204 2.08e-04

TonB polyproline region; TonB from Escherichia coli and its homologs are critical for the uptake of siderophores through the outer membrane of Gram-negative bacteria using chemiosmotic energy. The proline-rich segment of TonB exists in a PPII-like conformation. The result implies that the proline-rich segment of TonB possesses a length of more than 15 nm, sufficient to span the periplasm of Gram-negative bacteria.


Pssm-ID: 435086 [Multi-domain]  Cd Length: 136  Bit Score: 41.16  E-value: 2.08e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1345439630 159 VQVKAEPAPVPTPEPTPAVTPEP-APVPTPKPTPAATPEPAPVPTPK 204
Cdd:pfam16031  34 PQPAPEPVVEPEPEPEPEPLPEPpAPVVIHKPKPKPKPKPKPKPVKK 80
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 158-203 2.53e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 2.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:PRK07764  449 PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAP 494
DedD COG3147
Cell division protein DedD (periplasmic protein involved in septation) [Cell cycle control, ...
 158-204 3.25e-04

Cell division protein DedD (periplasmic protein involved in septation) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442381 [Multi-domain]  Cd Length: 140  Bit Score: 40.91  E-value: 3.25e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAV---TPEPAPVPTPK-PTPAATPEPAPVPTPK 204
Cdd:COG3147     9 PAAAAAPAAPAAAAAPAPAAaaaAAAPKPAAKPAaPKPAAAAAAAPAAKAA 59
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 158-203 4.17e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 4.17e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:PRK07764  457 PPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAA 502
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 157-204 4.88e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.57  E-value: 4.88e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1345439630  157 KPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK12270    52 AAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAP 99
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 162-204 5.05e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.57  E-value: 5.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1345439630  162 KAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK12270    59 AAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPA 101
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 164-203 5.44e-04

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 41.84  E-value: 5.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1345439630 164 EPAPVPTPEPTPAVTPEP----APVPTPKPTPAATPEPAPVPTP 203
Cdd:pfam07174  44 APPPPSTATAPPAPPPPPpapaAPAPPPPPAAPNAPNAPPPPAD 87
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
163-230 7.86e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 7.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1345439630 163 AEPAPVPTPEPTPAVTP---EPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAPILEDGTY 230
Cdd:PRK12323  448 PAPAPAPAAAPAAAARPaaaGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAP 518
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 158-204 9.15e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.90  E-value: 9.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1345439630 158 PVQVKAEPAPVPTPE-PTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK07764  399 PSAAAAAPAAAPAPAaAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAG 446
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
163-233 9.34e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 9.34e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1345439630 163 AEPAPVPTPEPTPAVTPePAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAPILEDGTYTID 233
Cdd:PRK12323  446 GAPAPAPAPAAAPAAAA-RPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPD 515
DUF3432 pfam11914
Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. ...
 158-203 1.17e-03

Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with pfam00096. This domain has two conserved sequence motifs: YPSPV and PSP.


Pssm-ID: 403204 [Multi-domain]  Cd Length: 98  Bit Score: 38.16  E-value: 1.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:pfam11914   9 VSSISSYSSSVTTSYPSPITTSYPSPVSTSYSSPVPSSYPSPVHTS 54
internalin_K NF033186
class 1 internalin InlK; Internalins, as found in the intracellular human pathogen Listeria ...
 52-203 1.19e-03

class 1 internalin InlK; Internalins, as found in the intracellular human pathogen Listeria monocytogenes, are paralogous surface-anchored proteins with an N-terminal signal peptide, leucine-rich repeats, and a C-terminal LPXTG processing and cell surface anchoring site. Members of this family are internalin K (InlK), a virulence factor. See articles PMID:17764999. for a general discussion of internalins, and PMID:21829365, PMID:22082958, and PMID:23958637 for more information about internalin K.


Pssm-ID: 467984 [Multi-domain]  Cd Length: 604  Bit Score: 41.22  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630  52 TEAASMMDTYAEKPAKLIVKNGNA-KISHKLAHSSWITqYQVEQNGSLK------DTTILESDASEDKRVVEFEVGVGDT 124
Cdd:NF033186  371 TEAEFLADIHAKTDDGSTVTSDFAdKVDFKTPGTYTVT-LQSENNSGLKaapvqvNVTIKEKTAITADEKITYKVDTSKT 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 125 AKKINARVKVDipgMNYHHAYDVQLAFKLDTLKP----VQVKAE---PAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEP 197
Cdd:NF033186  450 EAEFLADIKAK---TNDGTAITSDFATVVDLSKPgkyvVTLNAEndlQKALPVQVTVIVEKETPIPDPTPDPTPDPTPTP 526


                  ....*.
gi 1345439630 198 APVPTP 203
Cdd:NF033186  527 DPTPTP 532
PRK09752 PRK09752
AIDA-I family autotransporter YfaL;
164-201 1.27e-03

AIDA-I family autotransporter YfaL;


Pssm-ID: 182059 [Multi-domain]  Cd Length: 1250  Bit Score: 41.20  E-value: 1.27e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1345439630  164 EPAPVPTPEPTPavTPEPAPVPTPKPTPAATPEPAPVP 201
Cdd:PRK09752   917 EVTPPSPPDPDP--TPDPDPTPDPDPTPDPEPTPAYQP 952
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 158-219 1.28e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.41  E-value: 1.28e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1345439630  158 PVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTL 219
Cdd:PRK12270    59 AAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDEVTPL 120
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 169-224 1.29e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 40.68  E-value: 1.29e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1345439630 169 PTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAPI 224
Cdd:pfam07174  41 PEPAPPPPSTATAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPPPPADPNAPPPPPA 96
PHA01929 PHA01929
putative scaffolding protein
 159-201 1.48e-03

putative scaffolding protein


Pssm-ID: 177328  Cd Length: 306  Bit Score: 40.42  E-value: 1.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1345439630 159 VQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVP 201
Cdd:PHA01929   47 PQQLAIPTQQPQPVPTSAMTPHVVQQAPAQPAPAAPPAAGAAL 89
PRK09752 PRK09752
AIDA-I family autotransporter YfaL;
165-204 1.51e-03

AIDA-I family autotransporter YfaL;


Pssm-ID: 182059 [Multi-domain]  Cd Length: 1250  Bit Score: 41.20  E-value: 1.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1345439630  165 PAPvPTPEPTPavTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK09752   921 PSP-PDPDPTP--DPDPTPDPDPTPDPEPTPAYQPVLNAK 957
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 158-220 1.63e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 1.63e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKP-TPAATPEPAPVPTPKPTPIPAPVPTPVPTLV 220
Cdd:TIGR00601  88 AATPTSAPTPTPSPPASPASGMSAAPASAVEEkSPSEESATATAPESPSTSVPSSGSDAASTLV 151
SAV_2336_NTERM NF041121
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ...
 149-203 1.75e-03

SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.


Pssm-ID: 469044 [Multi-domain]  Cd Length: 473  Bit Score: 40.76  E-value: 1.75e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1345439630 149 LAFKLDTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:NF041121   11 LAAQMGRAAAPPSPEGPAPTAASQPATPPPPAAPPSPPGDPPEPPAPEPAPLPAP 65
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 163-231 2.24e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 40.64  E-value: 2.24e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1345439630  163 AEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAPILEDGTYT 231
Cdd:PRK12270    50 AAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDEVT 118
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 158-204 2.28e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.18  E-value: 2.28e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVTPEPAPV---PTPKPTPAATPEPAPVPTPK 204
Cdd:PRK14950  376 PSPVRPTPAPSTRPKAAAAANIPPKEPvreTATPPPVPPRPVAPPVPHTP 425
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 165-203 2.29e-03

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 40.64  E-value: 2.29e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1345439630  165 PAPVPTPEPTPAVTPEPA----------------------------------------PVPTPKPTPAATPEPAPVPTP 203
Cdd:pfam15324  985 PTPVPTPQPTPPCSPPSPlkepspvktpdsspcvsehdffpvkeippekgadtgpavsLVITPTVTPIATPPPAATPTP 1063
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 162-204 2.56e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 40.26  E-value: 2.56e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1345439630  162 KAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK12270    45 TAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPA 87
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 155-203 2.60e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 40.11  E-value: 2.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1345439630 155 TLKPVQVKAEPAPVPTPEPTPAVTPePAPVPTPKPTPAATPEPAPVPTP 203
Cdd:PRK14965  382 PAPPSAAWGAPTPAAPAAPPPAAAP-PVPPAAPARPAAARPAPAPAPPA 429
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 158-201 2.73e-03

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 38.30  E-value: 2.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVTPEPAPV----PTPKPTPAA-TPEPAPVP 201
Cdd:PRK05641   44 DLSAVQEQVPTPAPAPAPAVPSAPTPVapaaPAPAPASAGeNVVTAPMP 92
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 163-203 3.09e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 3.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1345439630 163 AEPAPVPTPEPTPAVTPEPAPVPT-PKPTPAATPEPAPVPTP 203
Cdd:PRK07764  427 AAPQPAPAPAPAPAPPSPAGNAPAgGAPSPPPAAAPSAQPAP 468
PRK14963 PRK14963
DNA polymerase III subunits gamma and tau; Provisional
 149-203 3.30e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184927 [Multi-domain]  Cd Length: 504  Bit Score: 39.82  E-value: 3.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1345439630 149 LAFKLDTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVP--TPKPTPAATPEPAPVPTP 203
Cdd:PRK14963  363 LTQRLNRLEKEVRSLRSAPTAAATAAGAPLPDFDPRPrgPPAPEPARSAEAPPLVAP 419
PHA03379 PHA03379
EBNA-3A; Provisional
 158-223 3.31e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.04  E-value: 3.31e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1345439630 158 PVQvKAEPAPVPTPE-----PTPAVTPEPAPVPTPKPT-PAATP-EPAPVPTPKPTPIPAPVPTPVPTLVPAP 223
Cdd:PHA03379  466 PVA-QLPPGPLQDLEpgdqlPGVVQDGRPACAPVPAPAgPIVRPwEASLSQVPGVAFAPVMPQPMPVEPVPVP 537
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 163-247 3.43e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 39.49  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 163 AEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPApvpTPKPTPIPAPVPTPVPTLVPAPILEDGTYTIDFTLYKDKTQ 242
Cdd:TIGR00601  85 APPAATPTSAPTPTPSPPASPASGMSAAPASAVEEK---SPSEESATATAPESPSTSVPSSGSDAASTLVVGSERETTIE 161


                  ....*
gi 1345439630 243 EVSKM 247
Cdd:TIGR00601 162 EIMEM 166
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 162-203 3.46e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 3.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1345439630 162 KAEPAPVPTPEPTPAVTPE-PAPVPTPKPTPAATPEPAPVPTP 203
Cdd:PRK07764  395 AAAAPSAAAAAPAAAPAPAaAAPAAAAAPAPAAAPQPAPAPAP 437
PRK10905 PRK10905
cell division protein DamX; Validated
 157-204 3.56e-03

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 39.15  E-value: 3.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1345439630 157 KPVQV-KAEPAPVPTP----EPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK10905  167 KPQATaKTEPKPVAQTpkrtEPAAPVASTKAPAATSTPAPKETATTAPVQTAS 219
flhF PRK14723
flagellar biosynthesis regulator FlhF; Provisional
 149-201 3.74e-03

flagellar biosynthesis regulator FlhF; Provisional


Pssm-ID: 237802 [Multi-domain]  Cd Length: 767  Bit Score: 39.78  E-value: 3.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1345439630 149 LAFKLDTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVP 201
Cdd:PRK14723   41 VAMLDEDLGAVAASAQAYAPPAPAPLPAALVAPAPAAASIAAPAAVPAPGAIG 93
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 157-203 4.15e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.41  E-value: 4.15e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1345439630 157 KPVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:PRK14950  382 TPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESA 428
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
158-199 4.17e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 4.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAP 199
Cdd:PRK12323  456 AAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP 497
Rib_recp_KP_reg pfam05104
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards ...
 164-204 4.61e-03

Ribosome receptor lysine/proline rich region; This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.


Pssm-ID: 461548 [Multi-domain]  Cd Length: 140  Bit Score: 37.41  E-value: 4.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1345439630 164 EPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:pfam05104  62 EPREFKTPDEAPSAALEPEPVPTPVPAPVEPEPAPPSESPA 102
PRK09752 PRK09752
AIDA-I family autotransporter YfaL;
170-203 4.79e-03

AIDA-I family autotransporter YfaL;


Pssm-ID: 182059 [Multi-domain]  Cd Length: 1250  Bit Score: 39.66  E-value: 4.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1345439630  170 TPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:PRK09752   919 TPPSPPDPDPTPDPDPTPDPDPTPDPEPTPAYQP 952
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 148-229 4.94e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.41  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1345439630 148 QLAFKLDTLKPVQVKAePAPV---PTPEPTPAVTPEPAPVPTPKPTPAATPEPA-PVPTPKPTPIPAPVPTPVPTLVPAP 223
Cdd:PRK14950  348 QLPLELAVIEALLVPV-PAPQpakPTAAAPSPVRPTPAPSTRPKAAAAANIPPKePVRETATPPPVPPRPVAPPVPHTPE 426


                  ....*.
gi 1345439630 224 ILEDGT 229
Cdd:PRK14950  427 SAPKLT 432
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
158-227 5.04e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 5.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1345439630 158 PVQVKAEPAPVPTPEPTPAVT--------PEPAPVPTPKPTPA-ATPEPAPVPTPKPTPIPAPVPTPVPTLVPAPILED 227
Cdd:PRK12323  417 RAVAAAPARRSPAPEALAAARqasargpgGAPAPAPAPAAAPAaAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDD 495
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 154-202 5.11e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.02  E-value: 5.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1345439630 154 DTLKPVQVKAEPAPVPTPEPTPAVTPEPapvPTPKPTPAATPEPAPVPT 202
Cdd:PRK14950  395 ANIPPKEPVRETATPPPVPPRPVAPPVP---HTPESAPKLTRAAIPVDE 440
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 157-203 5.40e-03

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 37.53  E-value: 5.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1345439630 157 KPVQVKAEPAPVPTPEPtpavtPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:PRK05641   32 KTYEVEAKGLGIDLSAV-----QEQVPTPAPAPAPAVPSAPTPVAPA 73
PRK06975 PRK06975
bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed
 160-204 5.82e-03

bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed


Pssm-ID: 235899 [Multi-domain]  Cd Length: 656  Bit Score: 38.93  E-value: 5.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1345439630 160 QVKAEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK06975  272 PATAAPAPSRMTDTNDSKSVTSQPAAAAAAPAPPPNPPATPPEPP 316
Rib_recp_KP_reg pfam05104
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards ...
 146-202 5.90e-03

Ribosome receptor lysine/proline rich region; This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.


Pssm-ID: 461548 [Multi-domain]  Cd Length: 140  Bit Score: 37.02  E-value: 5.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1345439630 146 DVQLAFKLDTLKPVQVkAEPAPVPTPEPTPAVTPEPAPVPTPKPTP---------AATPEPAPVPT 202
Cdd:pfam05104  61 EEPREFKTPDEAPSAA-LEPEPVPTPVPAPVEPEPAPPSESPAPSPkekkkkekkSAKVEPAETPE 125
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
157-204 6.32e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 38.79  E-value: 6.32e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1345439630 157 KPVQVKAEPAPVPTPEPTP-AVTPEPAPVPTPKPTPAATPEPAPVPTPK 204
Cdd:PRK14948  381 PNPSPPPAPIQPSAPKTKQaATTPSPPPAKASPPIPVPAEPTEPSPTPP 429
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 149-204 6.65e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.81  E-value: 6.65e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1345439630 149 LAFKLDTLKPVQVKAEPAPVPTPEPTPAVTPEPAPVPTP-KPTPAATPEPAPVPTPK 204
Cdd:PRK07764  374 LLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPaAAAPAAAAAPAPAAAPQ 430
PHA03247 PHA03247
large tegument protein UL36; Provisional
 165-226 6.99e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.15  E-value: 6.99e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1345439630  165 PAPVPTPEPTPAVT--PEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAPILE 226
Cdd:PHA03247  2871 PAAKPAAPARPPVRrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934
DedD COG3147
Cell division protein DedD (periplasmic protein involved in septation) [Cell cycle control, ...
 158-203 7.36e-03

Cell division protein DedD (periplasmic protein involved in septation) [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442381 [Multi-domain]  Cd Length: 140  Bit Score: 36.68  E-value: 7.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1345439630 158 PVQVKAEPAPVPTPEpTPAVTPEPAPV---PTPKPTPAATPE-PAPVPTP 203
Cdd:COG3147     2 AEEAAAAPAAAAAPA-APAAAAAPAPAaaaAAAAPKPAAKPAaPKPAAAA 50
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 171-203 7.63e-03

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 38.72  E-value: 7.63e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1345439630  171 PEPTPAVTPEPAPVP---TPKPTPAATPEPAPVPTP 203
Cdd:pfam15324  964 QREPPVAASVPGDLPtkeTLLPTPVPTPQPTPPCSP 999
PHA03247 PHA03247
large tegument protein UL36; Provisional
 154-203 7.81e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 7.81e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1345439630  154 DTLKPVQVKAEP-APVPTPEP-----TPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:PHA03247  2690 PTVGSLTSLADPpPPPPTPEPaphalVSATPLPPGPAAARQASPALPAAPAPPAVP 2745
TSKS pfam15358
Testis-specific serine kinase substrate; TSKS, testis-specific serine kinase substrate, is ...
 167-203 7.84e-03

Testis-specific serine kinase substrate; TSKS, testis-specific serine kinase substrate, is expressed in the testis and is downregulated in cancerous testicular tissue, in comparison with adjacent normal tissue. TSKS expression is very low to undetectable in seminoma, teratocarcinoma, embryonal, and Leydig cell tumours, while high in testicular tissue adjacent to tumours which contain pre-malignant carcinoma in situ. Recently it has been shown in human testis to be localized to the equatorial segment of ejaculated human sperm. The finding of a TSKS family member in mature sperm suggests that this family of kinases might play a role in sperm function. TSKS is localized during spermiogenesis to the centrioles of post-meiotic spermatids, where it reaches its greatest concentration during the period of flagellogenesis.


Pssm-ID: 434661  Cd Length: 455  Bit Score: 38.53  E-value: 7.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1345439630 167 PVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:pfam15358  48 STTENESTDDGSPPSAPLPPIKPVPSEYDDDDDTSSQ 84
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 163-223 8.92e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 38.72  E-value: 8.92e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1345439630  163 AEPAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTPKPTPIPAPVPTPVPTLVPAP 223
Cdd:PRK12270    48 AAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAP 108
Neisseria_TspB pfam05616
Neisseria meningitidis TspB protein; This family consists of several Neisseria meningitidis ...
 146-203 8.95e-03

Neisseria meningitidis TspB protein; This family consists of several Neisseria meningitidis TspB virulence factor proteins.


Pssm-ID: 283306 [Multi-domain]  Cd Length: 517  Bit Score: 38.54  E-value: 8.95e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1345439630 146 DVQLAFKLDtLKPVQVKAePAPVPTPEPTPAVTPEPAPVPTPKPTPAATPEPAPVPTP 203
Cdd:pfam05616 321 DVQVIPRPD-LTPASAEA-PHAQPLPEVSPAENPANNPDPDENPGTRPNPEPDPDLNP 376
COG5373 COG5373
Uncharacterized membrane protein [Function unknown];
163-203 9.53e-03

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 444140 [Multi-domain]  Cd Length: 854  Bit Score: 38.44  E-value: 9.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1345439630 163 AEPAP---VPTPEPTPAVTPEPAP-VPTPKPTPAATPEPAPVPTP 203
Cdd:COG5373    48 AEPEPeaaAAATAAAPEAAPAPVPeAPAAPPAAAEAPAPAAAAPP 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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