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Conserved domains on  [gi|1344793682|ref|XP_023938981|]
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paired box protein Pax-6-like [Bicyclus anynana]

Protein Classification

homeobox domain-containing protein( domain architecture ID 13432619)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0000981|GO:0043565
PubMed:  8768896|12520008|11470884
SCOP:  4000291

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
99-155 1.78e-28

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.05  E-value: 1.78e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1344793682  99 RRYRTTFSNVQLEQLEAAFHKTHYPDVFFREELAMRIDLTEARVQVWFQNRRAKWRK 155
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
71-186 4.17e-11

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 4.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344793682  71 AGDSQQYEEDEEYSPNSNSksdiPKRKQRRYRTTFsnvQLEQLEAAFHKTHYPDVFFREELAMRIDLTEARVQVWFQNRR 150
Cdd:COG5576    31 EVEAADSEMKLERKQDGSS----PPKSKRRRTTDE---QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKR 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1344793682 151 AKWRKQQKAGCE-YPPRQ----TRSPDPRSPSALALEMRDF 186
Cdd:COG5576   104 AKEKKKRSGKVEqRPGEEeadlAKIGSLSTGQISIIETLEF 144
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
99-155 1.78e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.05  E-value: 1.78e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1344793682  99 RRYRTTFSNVQLEQLEAAFHKTHYPDVFFREELAMRIDLTEARVQVWFQNRRAKWRK 155
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 98-154 2.89e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.93  E-value: 2.89e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1344793682   98 QRRYRTTFSNVQLEQLEAAFHKTHYPDVFFREELAMRIDLTEARVQVWFQNRRAKWR 154
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 99-157 3.08e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 91.92  E-value: 3.08e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1344793682  99 RRYRTTFSNVQLEQLEAAFHKTHYPDVFFREELAMRIDLTEARVQVWFQNRRAKWRKQQ 157
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
71-186 4.17e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 4.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344793682  71 AGDSQQYEEDEEYSPNSNSksdiPKRKQRRYRTTFsnvQLEQLEAAFHKTHYPDVFFREELAMRIDLTEARVQVWFQNRR 150
Cdd:COG5576    31 EVEAADSEMKLERKQDGSS----PPKSKRRRTTDE---QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKR 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1344793682 151 AKWRKQQKAGCE-YPPRQ----TRSPDPRSPSALALEMRDF 186
Cdd:COG5576   104 AKEKKKRSGKVEqRPGEEeadlAKIGSLSTGQISIIETLEF 144
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
99-155 1.78e-28

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.05  E-value: 1.78e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1344793682  99 RRYRTTFSNVQLEQLEAAFHKTHYPDVFFREELAMRIDLTEARVQVWFQNRRAKWRK 155
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 98-154 2.89e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.93  E-value: 2.89e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1344793682   98 QRRYRTTFSNVQLEQLEAAFHKTHYPDVFFREELAMRIDLTEARVQVWFQNRRAKWR 154
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 99-157 3.08e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 91.92  E-value: 3.08e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1344793682  99 RRYRTTFSNVQLEQLEAAFHKTHYPDVFFREELAMRIDLTEARVQVWFQNRRAKWRKQQ 157
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
71-186 4.17e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 4.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1344793682  71 AGDSQQYEEDEEYSPNSNSksdiPKRKQRRYRTTFsnvQLEQLEAAFHKTHYPDVFFREELAMRIDLTEARVQVWFQNRR 150
Cdd:COG5576    31 EVEAADSEMKLERKQDGSS----PPKSKRRRTTDE---QLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKR 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1344793682 151 AKWRKQQKAGCE-YPPRQ----TRSPDPRSPSALALEMRDF 186
Cdd:COG5576   104 AKEKKKRSGKVEqRPGEEeadlAKIGSLSTGQISIIETLEF 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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