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Conserved domains on  [gi|1343911068|ref|XP_023817207|]
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protocadherin Fat 3 isoform X4 [Oryzias latipes]

Protein Classification

LamG and EGF_CA domain-containing protein( domain architecture ID 10182226)

protein containing domains Cadherin_repeat, LamG, and EGF_CA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3261-3355 3.21e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 130.90  E-value: 3.21e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3261 TTVPEDVRVGTEVLRVYAASKDIGTNAEITYTIRSGNEHRRFHVHPHSGAIIVAQPLDYETCRDYFLTVEARDGGTPPLS 3340
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1343911068 3341 AVTTVNINLTDVNDN 3355
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3364-3460 1.04e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 129.74  E-value: 1.04e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3364 YTAFVSEDAFIGEFVVQLVAEDSDSHLNGAVLYSVVSGDQGSQFFIDPINGVIKVNKPLDRETIPSFSLTIRALDSGVPP 3443
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 3444 MSSTALVNIDVSDVNDN 3460
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1054-1149 3.96e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 3.96e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1054 TGVVKENARIGTTLLQVSANDDDTGRDGEIHYSIRDGSGLGRFSIDEETGVIYTTDILDRETKDSYWLTVYASDRGVVPQ 1133
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1343911068 1134 FTTIDVFVQVEDINDN 1149
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1158-1258 6.18e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 6.18e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1158 YRPSVPENSPPDVSVIQIQAQDPDTSPStslHWLSYQIVSGNPQHFFNMDPHSGLITTTShKLDRELQTEHVLEVVISDG 1237
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1343911068 1238 GPNPRQSTVLVIVQVLDENDN 1258
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2299-2398 1.55e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 1.55e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2299 SYSVSLSETAMIGTPVLQVIASDQDSEKNNIIRYQIFSQlhNSTDYFHIDSSSGLILTARMLDHELAHNYYFVVRATDNG 2378
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1343911068 2379 YPALSSEVTVTVTLNDMNDN 2398
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3050-3144 3.44e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 3.44e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3050 VYTASIPEDLPVHSLLLTVGATDADVGVNAQIQYSLHGSGSQD-FSIDPDTGEVKSLVTLDHEKTPSYRLVVQAMDGGG- 3127
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1343911068 3128 -QWCSAEIQLVVTDVNDN 3144
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 841-936 5.13e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 5.13e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  841 YKITIPENMAIGTDIIQVEATDKDMGPNGEVMYSILTSTT--PFGINSTTGMVYVAAQLDRELTSRFTLKIEARDRADKe 918
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP- 80

                           90
                   ....*....|....*...
gi 1343911068  919 sPKFSVTTLEIILEDVND 936
Cdd:cd11304     81 -PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 480-578 5.54e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 5.54e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  480 SYEVFVNESVPVGTNVLTVSATDEDRGENGYITYSISSLQPL-PFKIDQFSGVISTSSLLDFEsSTEIFVFLVRASDWGS 558
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDRE-EQSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 1343911068  559 PyRRESEVNVTIHLENVNDN 578
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3152-3250 9.55e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 9.55e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3152 QYTANVYENTIPKALLTRIQAIDPDEaGPGRMVVYSLT-DSAGGLFSIDHVSGVVILEHTLDREVQSTYQITVCASDQGS 3230
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 1343911068 3231 PlPLYSLVNVTITVLDINDN 3250
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1473-1570 2.25e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 2.25e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1473 YEVTISEDTPTDTEVLQIVASDRDE--HNELTYSLQSsidPNSMRLFRIHPTLGTIFTTQRLDHEACAQHILTVLVKDQD 1550
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1343911068 1551 FPYRKNLARVLIEVEDINDH 1570
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 737-831 1.90e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 1.90e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  737 IAVMEDLKIGSSVIKVNAYDGDTGFNGQVLFSFSGGNTDNCFNIDMQTGLISVFLPMDREKRDHYLLNITIYDLGIPQKM 816
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1343911068  817 AWRLLSIHIEDANDN 831
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 952-1042 2.68e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 2.68e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  952 EDLPVGTVVAWLETHDPDLGLGGQVRFSLV-NDHNGWFELDKASGAIRLTKELDYETQQFYNLTVKAKDKGRPvSLLSVT 1030
Cdd:cd11304      8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSSTA 86

                           90
                   ....*....|..
gi 1343911068 1031 FVELEVIDVNEN 1042
Cdd:cd11304     87 TVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1579-1674 4.84e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 4.84e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1579 YEGSVYESAAKGSAVVQVTALDKDKGKNAELRYSIEAGNTGNTFRIEPVLGIISVAHNLDLTNVGHYVVTVRVTDNGVPP 1658
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 1659 LSTNTVVRIAVT-LSDN 1674
Cdd:cd11304     82 LSSTATVTITVLdVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2508-2604 3.84e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 3.84e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2508 VYEAELRENAAVGTTVIQVKATDKDQEPFGHITYSFANDVGSDQFSIDSN-GYICTVEKLDREDPANrdILLIVAAQDLG 2586
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1343911068 2587 G--RVSYCTVQITLLDDNDN 2604
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3856-4016 1.26e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 102.88  E-value: 1.26e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3856 SLSFSGNSYIKYRLSERLQTELKLSLRIRTLQSHGIIMSMHTEHC---ILLKLVDGKLWFQLACGLGAGGSSpdilglSG 3932
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgdfLALELEDGRLVLRYDLGSGSLVLS------SK 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3933 HRINDGNWHTVALEMNRNFSRLALDNSFIEQRHAPSLMQTHFQERTIYLGALvqPPNSRslvdsQRDLRVHDGFQGCLDL 4012
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGL--PEDLK-----SPGLPVSPGFVGCIRD 147


                   ....
gi 1343911068 4013 VTLN 4016
Cdd:cd00110    148 LKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1683-1773 3.13e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 3.13e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1683 EYQTEVSENALIGTSITTVSAFSQ-----STLIYDIKQGNAEHVFQINQYSGVITNQKALDYETTESYTLIVQAVNMAG- 1756
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1343911068 1757 -MASNATLLIQILDENDN 1773
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1781-1886 7.43e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 7.43e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1781 HYYGSISEVAPVKSVVLNLHglplvirATDPDHNQNALLVYEIVENTAKKVFTVDSGTGSIRTIANLDHETFPIFIFHVQ 1860
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVS-------ATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*.
gi 1343911068 1861 VRDSGRPQLTadSPTEVTIQVIDSND 1886
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2831-2916 3.10e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 3.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2831 SYVATVMEGTAVGTKVIRVQASDPDSGANGQVTYRLgslikskgNSEPLSDIFNIDSNSGWIFIRTDLDHETSPFYTFTV 2910
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--------VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTV 72


                   ....*.
gi 1343911068 2911 VALDHG 2916
Cdd:cd11304     73 TATDGG 78
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-269 6.63e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 6.63e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  169 TYSVTIAESTPLRTSIAQVTATDADIGSNGEFYFFFKE--KVDLFAVHPTSGVVYLSGKLNVDEQTLYNLEILAVDRgmk 246
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1343911068  247 lyGNNGVSSTAKLFVHVERLNEH 269
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2096-2187 1.08e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 1.08e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2096 PYYAVVQVDAEQGSHIFTVIAVDGDKGVNGEVTYHLKYDHD--HFEINQKTGIISLKKS--FEsdlSNAEYQIVIYAKDG 2171
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPldRE---EQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1343911068 2172 GDEPLSSTVEFPITVV 2187
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2945-3042 1.73e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 1.73e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2945 HYIGTVRESDPPGEVVAVLNTRDEDSSVvNQHISIHITGGNDRGVFALRLVQGEwkMYVKGPLDREKRNFYLINITATDG 3024
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1343911068 3025 ---LFVSQTKVEVTVMDANDN 3042
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2407-2500 1.96e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 1.96e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2407 YEAYVSELAPRGHFITCVQASDADSSDFDKLEYSILSGNERMHFVLEKSTGILALsshrKQKMD----PTYSLNVSVSDG 2482
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITT----AKPLDreeqSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1343911068 2483 ---VFTSTAQVHIKVLGANLH 2500
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2199-2291 4.02e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 4.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2199 YSVYVNEDVEVYTPIISINST---SPEGQKIIYTIVDGDPSLQFDIGFDTGVISVIHCLDYEVTSSYHLTVRATD-YLTG 2274
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 2275 AHAEVDLGVFIQDINDN 2291
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1266-1356 6.23e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 6.23e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1266 VYKVKLPERERRKkaEPIYRVFAYDLDEGPNSDISYSIVDGNEDGKFVIDPKTGTVQSRRAFPAGGYD--ILTIKATDNG 1343
Cdd:cd11304      1 SYEVSVPENAPPG--TVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSsyTLTVTATDGG 78

                           90
                   ....*....|...
gi 1343911068 1344 RPQKSSTARLHIE 1356
Cdd:cd11304     79 GPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3470-3565 2.43e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 2.43e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3470 TAVIQENKPIGTTILQLSVIDRDSSRNGpPFSFQILSGNEGREFVL-KEDGTLTANQVFKREFATEYIIQIQVSDSGKPS 3548
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 3549 LSSSTMLTVAVIEESLN 3565
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1375-1464 1.52e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1375 YNFTVMENDKVAEIVGVVSLQW----SSAPVWFDIRGGNSNSVFDVEKAVGTILIAKPLDAEQRSFYNLTVLATDG---T 1447
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDpdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpP 81

                           90
                   ....*....|....*..
gi 1343911068 1448 HTAYTQVHILVLDNNDN 1464
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2612-2707 3.82e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.66  E-value: 3.82e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2612 EYQASLKHDVTKGFLVTQLQAHDLDDGSNAKVRYSLYSEarvPVVDILEIDPDNGWMVTKGSFSHLRNSVLSFFVKAVDG 2691
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1343911068 2692 GIPARHSLVPVYIHVL 2707
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4122-4161 1.68e-16

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 75.75  E-value: 1.68e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1343911068 4122 DVNECDRNNPegeCENGGTCVNTPGSFYCNCTPGFVGQRC 4161
Cdd:cd00054      1 DIDECASGNP---CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2720-2823 4.08e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 4.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2720 HYSFNIPENTPIGSVIGTVRVSIPPEYSSLTATFATANGESGEnnremVFLVEKDTGVIKLDKALDHEAIKEFYFKVTAT 2799
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 1343911068 2800 vKQAKLDSMTSANVKVNVFDINDN 2823
Cdd:cd11304     76 -DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 591-676 9.36e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 9.36e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  591 ISADFPVGEVITTVSAIDIDELE--LVKYKILSGNEQRLFDLNPDSGVLTLGHPLTSlgPQKGVFSLKITATDGEN--LS 666
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDR--EEQSSYTLTVTATDGGGppLS 83

                           90
                   ....*....|
gi 1343911068  667 DHMYVNISVV 676
Cdd:cd11304     84 STATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1994-2088 4.47e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.03  E-value: 4.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1994 IYYSSIKENLPNITKVAVVSAV--GNHLNEPLKYSLL--NAGTHFRIRPTSGVIQTTGiPFDREEQEFYELIAEAKREHD 2069
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1343911068 2070 HRHVARVVVKVQVEDINDN 2088
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1911-1981 1.01e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 1.01e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343911068 1911 LQVSAIDPDKDVATELTFSLVDGS-LEHFDINPTSGIIVV-KNINF-SKELFRFTVQVSDG---KFSSSALVTLNVQ 1981
Cdd:cd11304     17 LTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTaKPLDReEQSSYTLTVTATDGggpPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 53-160 2.99e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.94  E-value: 2.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   53 VYHATIYENSAArtyaNSKIkmgITLDKRFLD------IRYRIVSGDEEGFFKAEEYvLGDfcflrIRTKGGnsaiLNRE 126
Cdd:cd11304      1 SYEVSVPENAPP----GTVV---LTVSATDPDsgengeVTYSIVSGNEDGLFSIDPS-TGE-----ITTAKP----LDRE 63

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1343911068  127 IQSNYVLTVKAFVKGEVFLEAWTKVSVQVLDMND 160
Cdd:cd11304     64 EQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3573-3644 6.59e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.17  E-value: 6.59e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343911068 3573 EIHVVTMEDEFPGGVIGQLHATDAD--PYDALTFGHAPQAQHGLFKISPHDGRIIALGGLDA---GSYSLNVTVSDG 3644
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDReeqSSYTLTVTATDG 77
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 385-472 1.44e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.44e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  385 YEIAINEVSPPRTVVCAVKIR----PEHENVEYILMPSKDLDFFQINTFTGVISTTRWLTKVSNNLFNLEVVeiSSDL-- 458
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT--ATDGgg 79

                           90
                   ....*....|....*....
gi 1343911068  459 -----RVKVLITIEDANDN 472
Cdd:cd11304     80 pplssTATVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4047-4082 5.01e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 5.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1343911068 4047 DPCL-HQPCHNGATCNSLPsGGFSCSCSHQFTGGNCE 4082
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4090-4120 4.67e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 4.67e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1343911068 4090 PNPCQNSGVCKPIGNAFLCSCRRGFRGLVCE 4120
Cdd:cd00054      8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 265-368 3.86e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.08  E-value: 3.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  265 RLNEHAPVISAVTHhdsklykslayaiVNVDDSDEGVNGEIdSVIIVDGDPLGQFFLEktkENEYAIKATESINWESFPF 344
Cdd:cd11304      5 SVPENAPPGTVVLT-------------VSATDPDSGENGEV-TYSIVSGNEDGLFSID---PSTGEITTAKPLDREEQSS 67

                           90       100
                   ....*....|....*....|....
gi 1343911068  345 gCNITLQAKDRGIPPKLSTFPVHI 368
Cdd:cd11304     68 -YTLTVTATDGGGPPLSSTATVTI 90
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3261-3355 3.21e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 130.90  E-value: 3.21e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3261 TTVPEDVRVGTEVLRVYAASKDIGTNAEITYTIRSGNEHRRFHVHPHSGAIIVAQPLDYETCRDYFLTVEARDGGTPPLS 3340
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1343911068 3341 AVTTVNINLTDVNDN 3355
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3364-3460 1.04e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 129.74  E-value: 1.04e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3364 YTAFVSEDAFIGEFVVQLVAEDSDSHLNGAVLYSVVSGDQGSQFFIDPINGVIKVNKPLDRETIPSFSLTIRALDSGVPP 3443
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 3444 MSSTALVNIDVSDVNDN 3460
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1054-1149 3.96e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 3.96e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1054 TGVVKENARIGTTLLQVSANDDDTGRDGEIHYSIRDGSGLGRFSIDEETGVIYTTDILDRETKDSYWLTVYASDRGVVPQ 1133
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1343911068 1134 FTTIDVFVQVEDINDN 1149
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1158-1258 6.18e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 6.18e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1158 YRPSVPENSPPDVSVIQIQAQDPDTSPStslHWLSYQIVSGNPQHFFNMDPHSGLITTTShKLDRELQTEHVLEVVISDG 1237
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1343911068 1238 GPNPRQSTVLVIVQVLDENDN 1258
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2299-2398 1.55e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 1.55e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2299 SYSVSLSETAMIGTPVLQVIASDQDSEKNNIIRYQIFSQlhNSTDYFHIDSSSGLILTARMLDHELAHNYYFVVRATDNG 2378
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1343911068 2379 YPALSSEVTVTVTLNDMNDN 2398
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3050-3144 3.44e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 3.44e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3050 VYTASIPEDLPVHSLLLTVGATDADVGVNAQIQYSLHGSGSQD-FSIDPDTGEVKSLVTLDHEKTPSYRLVVQAMDGGG- 3127
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1343911068 3128 -QWCSAEIQLVVTDVNDN 3144
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 841-936 5.13e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 5.13e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  841 YKITIPENMAIGTDIIQVEATDKDMGPNGEVMYSILTSTT--PFGINSTTGMVYVAAQLDRELTSRFTLKIEARDRADKe 918
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP- 80

                           90
                   ....*....|....*...
gi 1343911068  919 sPKFSVTTLEIILEDVND 936
Cdd:cd11304     81 -PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 480-578 5.54e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 5.54e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  480 SYEVFVNESVPVGTNVLTVSATDEDRGENGYITYSISSLQPL-PFKIDQFSGVISTSSLLDFEsSTEIFVFLVRASDWGS 558
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDRE-EQSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 1343911068  559 PyRRESEVNVTIHLENVNDN 578
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3152-3250 9.55e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 9.55e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3152 QYTANVYENTIPKALLTRIQAIDPDEaGPGRMVVYSLT-DSAGGLFSIDHVSGVVILEHTLDREVQSTYQITVCASDQGS 3230
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 1343911068 3231 PlPLYSLVNVTITVLDINDN 3250
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1473-1570 2.25e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 2.25e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1473 YEVTISEDTPTDTEVLQIVASDRDE--HNELTYSLQSsidPNSMRLFRIHPTLGTIFTTQRLDHEACAQHILTVLVKDQD 1550
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1343911068 1551 FPYRKNLARVLIEVEDINDH 1570
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3382-3462 3.10e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 107.82  E-value: 3.10e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3382 VAEDSDSHLNGAVLYSVVSGDQGSQFFIDPINGVIKVNKPLDRETIPSFSLTIRALDSGVPPMSSTALVNIDVSDVNDNP 3461
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1343911068  3462 P 3462
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3278-3357 8.96e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 106.28  E-value: 8.96e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3278 AASKDIGTNAEITYTIRSGNEHRRFHVHPHSGAIIVAQPLDYETCRDYFLTVEARDGGTPPLSAVTTVNINLTDVNDNAP 3357
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 737-831 1.90e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 1.90e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  737 IAVMEDLKIGSSVIKVNAYDGDTGFNGQVLFSFSGGNTDNCFNIDMQTGLISVFLPMDREKRDHYLLNITIYDLGIPQKM 816
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1343911068  817 AWRLLSIHIEDANDN 831
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 952-1042 2.68e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 2.68e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  952 EDLPVGTVVAWLETHDPDLGLGGQVRFSLV-NDHNGWFELDKASGAIRLTKELDYETQQFYNLTVKAKDKGRPvSLLSVT 1030
Cdd:cd11304      8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSSTA 86

                           90
                   ....*....|..
gi 1343911068 1031 FVELEVIDVNEN 1042
Cdd:cd11304     87 TVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1579-1674 4.84e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 4.84e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1579 YEGSVYESAAKGSAVVQVTALDKDKGKNAELRYSIEAGNTGNTFRIEPVLGIISVAHNLDLTNVGHYVVTVRVTDNGVPP 1658
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 1659 LSTNTVVRIAVT-LSDN 1674
Cdd:cd11304     82 LSSTATVTITVLdVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1071-1151 1.53e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.81  E-value: 1.53e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  1071 SANDDDTGRDGEIHYSIRDGSGLGRFSIDEETGVIYTTDILDRETKDSYWLTVYASDRGVVPQFTTIDVFVQVEDINDNA 1150
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1343911068  1151 P 1151
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2508-2604 3.84e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 3.84e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2508 VYEAELRENAAVGTTVIQVKATDKDQEPFGHITYSFANDVGSDQFSIDSN-GYICTVEKLDREDPANrdILLIVAAQDLG 2586
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1343911068 2587 G--RVSYCTVQITLLDDNDN 2604
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3262-3350 4.45e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.99  E-value: 4.45e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3262 TVPEDVRVGTEVLRVYAASKDIGTNAEITYTIRSGNEHRRFHVHPHSGAIIVAQPLDYETCRDYFLTVEARDGGTPPLSA 3341
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1343911068 3342 VTTVNINLT 3350
Cdd:pfam00028   84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3364-3454 6.37e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.61  E-value: 6.37e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3364 YTAFVSEDAFIGEFVVQLVAEDSDSHLNGAVLYSVVSGDQGSQFFIDPINGVIKVNKPLDRETIPSFSLTIRALDSGVPP 3443
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1343911068 3444 MSSTALVNIDV 3454
Cdd:pfam00028   81 LSSTATVTITV 91
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3856-4016 1.26e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 102.88  E-value: 1.26e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3856 SLSFSGNSYIKYRLSERLQTELKLSLRIRTLQSHGIIMSMHTEHC---ILLKLVDGKLWFQLACGLGAGGSSpdilglSG 3932
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgdfLALELEDGRLVLRYDLGSGSLVLS------SK 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3933 HRINDGNWHTVALEMNRNFSRLALDNSFIEQRHAPSLMQTHFQERTIYLGALvqPPNSRslvdsQRDLRVHDGFQGCLDL 4012
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGL--PEDLK-----SPGLPVSPGFVGCIRD 147


                   ....
gi 1343911068 4013 VTLN 4016
Cdd:cd00110    148 LKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1683-1773 3.13e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 3.13e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1683 EYQTEVSENALIGTSITTVSAFSQ-----STLIYDIKQGNAEHVFQINQYSGVITNQKALDYETTESYTLIVQAVNMAG- 1756
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1343911068 1757 -MASNATLLIQILDENDN 1773
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1781-1886 7.43e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 7.43e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1781 HYYGSISEVAPVKSVVLNLHglplvirATDPDHNQNALLVYEIVENTAKKVFTVDSGTGSIRTIANLDHETFPIFIFHVQ 1860
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVS-------ATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*.
gi 1343911068 1861 VRDSGRPQLTadSPTEVTIQVIDSND 1886
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2831-2916 3.10e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 3.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2831 SYVATVMEGTAVGTKVIRVQASDPDSGANGQVTYRLgslikskgNSEPLSDIFNIDSNSGWIFIRTDLDHETSPFYTFTV 2910
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--------VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTV 72


                   ....*.
gi 1343911068 2911 VALDHG 2916
Cdd:cd11304     73 TATDGG 78
Cadherin pfam00028
Cadherin domain;
1161-1253 3.57e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.52  E-value: 3.57e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1161 SVPENSPPDVSVIQIQAQDPDTSPSTSLhwlSYQIVSGNPQHFFNMDPHSGLITTTSHkLDRELQTEHVLEVVISDGGPN 1240
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRI---FYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1343911068 1241 PRQSTVLVIVQVL 1253
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3070-3146 4.21e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 4.21e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3070 ATDADVGVNAQIQYSLHGSGSQD-FSIDPDTGEVKSLVTLDHEKTPSYRLVVQAMDGGGQ--WCSAEIQLVVTDVNDNPP 3146
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2319-2400 5.53e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.80  E-value: 5.53e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  2319 ASDQDSEKNNIIRYQIFSQlhNSTDYFHIDSSSGLILTARMLDHELAHNYYFVVRATDNGYPALSSEVTVTVTLNDMNDN 2398
Cdd:smart00112    2 ATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1343911068  2399 AP 2400
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-269 6.63e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 6.63e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  169 TYSVTIAESTPLRTSIAQVTATDADIGSNGEFYFFFKE--KVDLFAVHPTSGVVYLSGKLNVDEQTLYNLEILAVDRgmk 246
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1343911068  247 lyGNNGVSSTAKLFVHVERLNEH 269
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1054-1144 1.83e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.59  E-value: 1.83e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1054 TGVVKENARIGTTLLQVSANDDDTGRDGEIHYSIRDGSGLGRFSIDEETGVIYTTDILDRETKDSYWLTVYASDRGVVPQ 1133
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1343911068 1134 FTTIDVFVQVE 1144
Cdd:pfam00028   82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1176-1260 2.60e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 2.60e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  1176 QAQDPDTSPStslHWLSYQIVSGNPQHFFNMDPHSGLITTTsHKLDRELQTEHVLEVVISDGGPNPRQSTVLVIVQVLDE 1255
Cdd:smart00112    1 SATDADSGEN---GKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 1343911068  1256 NDNKP 1260
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
1579-1670 2.89e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.21  E-value: 2.89e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1579 YEGSVYESAAKGSAVVQVTALDKDKGKNAELRYSIEAGNTGNTFRIEPVLGIISVAHNLDLTNVGHYVVTVRVTDNGVPP 1658
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1343911068 1659 LSTNTVVRIAVT 1670
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3171-3252 1.63e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 1.63e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3171 QAIDPDEaGPGRMVVYSLTD-SAGGLFSIDHVSGVVILEHTLDREVQSTYQITVCASDQGSPlPLYSLVNVTITVLDIND 3249
Cdd:smart00112    1 SATDADS-GENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1343911068  3250 NHP 3252
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 753-833 8.30e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.63  E-value: 8.30e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   753 NAYDGDTGFNGQVLFSFSGGNTDNCFNIDMQTGLISVFLPMDREKRDHYLLNITIYDLGIPQKMAWRLLSIHIEDANDNA 832
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1343911068   833 P 833
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2096-2187 1.08e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 1.08e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2096 PYYAVVQVDAEQGSHIFTVIAVDGDKGVNGEVTYHLKYDHD--HFEINQKTGIISLKKS--FEsdlSNAEYQIVIYAKDG 2171
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPldRE---EQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1343911068 2172 GDEPLSSTVEFPITVV 2187
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2945-3042 1.73e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 1.73e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2945 HYIGTVRESDPPGEVVAVLNTRDEDSSVvNQHISIHITGGNDRGVFALRLVQGEwkMYVKGPLDREKRNFYLINITATDG 3024
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1343911068 3025 ---LFVSQTKVEVTVMDANDN 3042
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2407-2500 1.96e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 1.96e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2407 YEAYVSELAPRGHFITCVQASDADSSDFDKLEYSILSGNERMHFVLEKSTGILALsshrKQKMD----PTYSLNVSVSDG 2482
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITT----AKPLDreeqSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1343911068 2483 ---VFTSTAQVHIKVLGANLH 2500
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1807-1889 2.03e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 2.03e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  1807 RATDPDHNQNALLVYEIVENTAKKVFTVDSGTGSIRTIANLDHETFPIFIFHVQVRDSGRPQLTadSPTEVTIQVIDSND 1886
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS--STATVTITVLDVND 78


                    ...
gi 1343911068  1887 SPP 1889
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
3051-3139 3.47e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 3.47e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3051 YTASIPEDLPVHSLLLTVGATDADVGVNAQIQYSLHGSGS-QDFSIDPDTGEVKSLVTLDHEKTPSYRLVVQAMDGGGQW 3129
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|
gi 1343911068 3130 CSAEIQLVVT 3139
Cdd:pfam00028   81 LSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 966-1042 3.51e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 3.51e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1343911068   966 HDPDLGLGGQVRFSLV-NDHNGWFELDKASGAIRLTKELDYETQQFYNLTVKAKDKGRPvSLLSVTFVELEVIDVNEN 1042
Cdd:smart00112    3 TDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2199-2291 4.02e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 4.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2199 YSVYVNEDVEVYTPIISINST---SPEGQKIIYTIVDGDPSLQFDIGFDTGVISVIHCLDYEVTSSYHLTVRATD-YLTG 2274
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 2275 AHAEVDLGVFIQDINDN 2291
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 499-580 6.17e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 6.17e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   499 SATDEDRGENGYITYSISSLQP-LPFKIDQFSGVISTSSLLDFEsSTEIFVFLVRASDWGSPyRRESEVNVTIHLENVND 577
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDRE-EQPEYTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1343911068   578 NQP 580
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1266-1356 6.23e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 6.23e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1266 VYKVKLPERERRKkaEPIYRVFAYDLDEGPNSDISYSIVDGNEDGKFVIDPKTGTVQSRRAFPAGGYD--ILTIKATDNG 1343
Cdd:cd11304      1 SYEVSVPENAPPG--TVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSsyTLTVTATDGG 78

                           90
                   ....*....|...
gi 1343911068 1344 RPQKSSTARLHIE 1356
Cdd:cd11304     79 GPPLSSTATVTIT 91
Cadherin pfam00028
Cadherin domain;
841-932 7.85e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.27  E-value: 7.85e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  841 YKITIPENMAIGTDIIQVEATDKDMGPNGEVMYSILTSTTP--FGINSTTGMVYVAAQLDRELTSRFTLKIEARDRADKe 918
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP- 79

                           90
                   ....*....|....
gi 1343911068  919 sPKFSVTTLEIILE 932
Cdd:pfam00028   80 -PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 860-939 2.08e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 2.08e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   860 ATDKDMGPNGEVMYSILTSTT--PFGINSTTGMVYVAAQLDRELTSRFTLKIEARDRAdkESPKFSVTTLEIILEDVNDC 937
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1343911068   938 SP 939
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3470-3565 2.43e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 2.43e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3470 TAVIQENKPIGTTILQLSVIDRDSSRNGpPFSFQILSGNEGREFVL-KEDGTLTANQVFKREFATEYIIQIQVSDSGKPS 3548
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 3549 LSSSTMLTVAVIEESLN 3565
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2832-2917 2.75e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 2.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2832 YVATVMEGTAVGTKVIRVQASDPDSGANGQVTYRLgslikSKGNSeplSDIFNIDSNSGWIFIRTDLDHETSPFYTFTVV 2911
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-----LGGGP---GGNFRIDPDTGDISTTKPLDRESIGEYELTVE 72


                   ....*.
gi 1343911068 2912 ALDHGE 2917
Cdd:pfam00028   73 ATDSGG 78
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3883-4018 2.94e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.62  E-value: 2.94e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3883 IRTLQSHGIIMSMHTE--HCILLKLVDGKLWFQLACGlgaggSSPDILGLSGHRINDGNWHTVALEMNRNFSRLALDNSF 3960
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGgsDFLALELVNGRLVLRYDLG-----SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1343911068 3961 IEQRHAPSLMQTHFQERTIYLGALVQPPNSRSLVdsqrdlrVHDGFQGCLDLVTLNDN 4018
Cdd:pfam02210   76 VVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALP-------VRAGFVGCIRDVRVNGE 126
Cadherin pfam00028
Cadherin domain;
2300-2392 3.01e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 3.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2300 YSVSLSETAMIGTPVLQVIASDQDSEKNNIIRYQIFSqlHNSTDYFHIDSSSGLILTARMLDHELAHNYYFVVRATDNGY 2379
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG--GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1343911068 2380 PALSSEVTVTVTL 2392
Cdd:pfam00028   79 PPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
952-1023 7.58e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 7.58e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1343911068  952 EDLPVGTVVAWLETHDPDLGLGGQVRFSLVNDH-NGWFELDKASGAIRLTKELDYETQQFYNLTVKAKDKGRP 1023
Cdd:pfam00028    7 ENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
2509-2599 1.20e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2509 YEAELRENAAVGTTVIQVKATDKDQEPFGHITYSFANDVGSDQFSID-SNGYICTVEKLDREdpANRDILLIVAAQDLG- 2586
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRE--SIGEYELTVEATDSGg 78

                           90
                   ....*....|....
gi 1343911068 2587 -GRVSYCTVQITLL 2599
Cdd:pfam00028   79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1707-1775 1.24e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.24e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1343911068  1707 STLIYDIKQGNAEHVFQINQYSGVITNQKALDYETTESYTLIVQAVNMAG--MASNATLLIQILDENDNPP 1775
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1375-1464 1.52e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1375 YNFTVMENDKVAEIVGVVSLQW----SSAPVWFDIRGGNSNSVFDVEKAVGTILIAKPLDAEQRSFYNLTVLATDG---T 1447
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDpdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpP 81

                           90
                   ....*....|....*..
gi 1343911068 1448 HTAYTQVHILVLDNNDN 1464
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3153-3245 3.56e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 3.56e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3153 YTANVYENTIPKALLTRIQAIDPDEaGPGRMVVYSLT-DSAGGLFSIDHVSGVVILEHTLDREVQSTYQITVCASDQGSP 3231
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDL-GPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|....
gi 1343911068 3232 lPLYSLVNVTITVL 3245
Cdd:pfam00028   80 -PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2612-2707 3.82e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.66  E-value: 3.82e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2612 EYQASLKHDVTKGFLVTQLQAHDLDDGSNAKVRYSLYSEarvPVVDILEIDPDNGWMVTKGSFSHLRNSVLSFFVKAVDG 2691
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1343911068 2692 GIPARHSLVPVYIHVL 2707
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
481-573 1.42e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 1.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  481 YEVFVNESVPVGTNVLTVSATDEDRGENGYITYSISS-LQPLPFKIDQFSGVISTSSLLDFEsSTEIFVFLVRASDWGSP 559
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|....
gi 1343911068  560 YrRESEVNVTIHLE 573
Cdd:pfam00028   80 P-LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1684-1768 1.60e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 1.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1684 YQTEVSENALIGTSITTVSAFS-----QSTLIYDIKQGNAEHVFQINQYSGVITNQKALDYETTESYTLIVQAVNMA--G 1756
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 1343911068 1757 MASNATLLIQIL 1768
Cdd:pfam00028   81 LSSTATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4122-4161 1.68e-16

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 75.75  E-value: 1.68e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1343911068 4122 DVNECDRNNPegeCENGGTCVNTPGSFYCNCTPGFVGQRC 4161
Cdd:cd00054      1 DIDECASGNP---CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1597-1670 1.86e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 1.86e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1343911068  1597 TALDKDKGKNAELRYSIEAGNTGNTFRIEPVLGIISVAHNLDLTNVGHYVVTVRVTDNGVPPLSTNTVVRIAVT 1670
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2220-2293 6.28e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 6.28e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343911068  2220 SPEGQKIIYTIVDGDPSLQFDIGFDTGVISVIHCLDYEVTSSYHLTVRATDYLTGAH-AEVDLGVFIQDINDNPP 2293
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLsSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1473-1565 7.21e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 7.21e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1473 YEVTISEDTPTDTEVLQIVASDRDE--HNELTYSLQSsidPNSMRLFRIHPTLGTIFTTQRLDHEACAQHILTVLVKDQD 1550
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1343911068 1551 FPYRKNLARVLIEVE 1565
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1267-1356 9.20e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 9.20e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1267 YKVKLPERERRKKaePIYRVFAYDLDEGPNSDISYSIVDGNEDGKFVIDPKTGTVQSRRA--FPAGGYDILTIKATDNGR 1344
Cdd:pfam00028    1 YSASVPENAPVGT--EVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPldRESIGEYELTVEATDSGG 78

                           90
                   ....*....|..
gi 1343911068 1345 PQKSSTARLHIE 1356
Cdd:pfam00028   79 PPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2527-2606 1.62e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 1.62e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  2527 KATDKDQEPFGHITYSFANDVGSDQFSIDSN-GYICTVEKLDREDPANrdILLIVAAQDLGG--RVSYCTVQITLLDDND 2603
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPE--YTLTVEATDGGGppLSSTATVTITVLDVND 78


                    ...
gi 1343911068  2604 NSP 2606
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
1782-1882 2.44e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 2.44e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1782 YYGSISEVAPVKSVVLNLHglplvirATDPDHNQNALLVYEIVENTAKKVFTVDSGTGSIRTIANLDHETFPIFIFHVQV 1861
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVT-------ATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90       100
                   ....*....|....*....|.
gi 1343911068 1862 RDSGRPQLTadSPTEVTIQVI 1882
Cdd:pfam00028   74 TDSGGPPLS--STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2720-2823 4.08e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 4.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2720 HYSFNIPENTPIGSVIGTVRVSIPPEYSSLTATFATANGESGEnnremVFLVEKDTGVIKLDKALDHEAIKEFYFKVTAT 2799
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 1343911068 2800 vKQAKLDSMTSANVKVNVFDINDN 2823
Cdd:cd11304     76 -DGGGPPLSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
3878-4018 4.23e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 75.07  E-value: 4.23e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3878 KLSLRIRTLQSHGIIMSMH----TEHcILLKLVDGKLWFQLACGlgaggSSPDILGLSGHRINDGNWHTVALEMNRNFSR 3953
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskggGDY-LALELRDGRLVLRYDLG-----SGPARLTSDPTPLNDGQWHRVAVERNGRSVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343911068  3954 LALDNSFIEQRHAPSLMQTHFQERTIYLGALvqPPNSRslvdsQRDLRVHDGFQGCLDLVTLNDN 4018
Cdd:smart00282   75 LSVDGGNRVSGESPGGLTILNLDGPLYLGGL--PEDLK-----LPPLPVTPGFRGCIRNLKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1491-1572 4.28e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 4.28e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  1491 VASDRDE--HNELTYSLqssIDPNSMRLFRIHPTLGTIFTTQRLDHEACAQHILTVLVKDQDFPYRKNLARVLIEVEDIN 1568
Cdd:smart00112    1 SATDADSgeNGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1343911068  1569 DHVP 1572
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
3470-3560 6.33e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 6.33e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3470 TAVIQENKPIGTTILQLSVIDRDSSRNGPPFsFQILSGNEGREFVL-KEDGTLTANQVFKREFATEYIIQIQVSDSGKPS 3548
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1343911068 3549 LSSSTMLTVAVI 3560
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2850-2939 6.45e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 6.45e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  2850 QASDPDSGANGQVTYRLgslikskgNSEPLSDIFNIDSNSGWIFIRTDLDHETSPFYTFTVVALDHGEvLSLSSTTTVTV 2929
Cdd:smart00112    1 SATDADSGENGKVTYSI--------LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG-PPLSSTATVTI 71

                            90
                    ....*....|
gi 1343911068  2930 TVSDVNDNAP 2939
Cdd:smart00112   72 TVLDVNDNAP 81
EGF_CA smart00179
Calcium-binding EGF-like domain;
4122-4161 1.32e-14

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 70.35  E-value: 1.32e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1343911068  4122 DVNECDRNNPegeCENGGTCVNTPGSFYCNCTPGFV-GQRC 4161
Cdd:smart00179    1 DIDECASGNP---CQNGGTCVNTVGSYRCECPPGYTdGRNC 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1288-1356 7.82e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 7.82e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1343911068  1288 AYDLDEGPNSDISYSIVDGNEDGKFVIDPKTGTVQSRRAF---PAGGYDiLTIKATDNGRPQKSSTARLHIE 1356
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 591-676 9.36e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 9.36e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  591 ISADFPVGEVITTVSAIDIDELE--LVKYKILSGNEQRLFDLNPDSGVLTLGHPLTSlgPQKGVFSLKITATDGEN--LS 666
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDR--EEQSSYTLTVTATDGGGppLS 83

                           90
                   ....*....|
gi 1343911068  667 DHMYVNISVV 676
Cdd:cd11304     84 STATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1397-1466 1.90e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 1.90e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1343911068  1397 SSAPVWFDIRGGNSNSVFDVEKAVGTILIAKPLDAEQRSFYNLTVLATDG---THTAYTQVHILVLDNNDNDP 1466
Cdd:smart00112    9 ENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
737-826 1.91e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 1.91e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  737 IAVMEDLKIGSSVIKVNAYDGDTGFNGQVLFSFSGGNTDNCFNIDMQTGLISVFLPMDREKRDHYLLNITIYDLGIPQKM 816
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1343911068  817 AWRLLSIHIE 826
Cdd:pfam00028   83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2964-3044 1.56e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 1.56e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  2964 NTRDEDSSVvNQHISIHITGGNDRGVFALRLVQGEwkMYVKGPLDREKRNFYLINITATDG---LFVSQTKVEVTVMDAN 3040
Cdd:smart00112    1 SATDADSGE-NGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVN 77


                    ....
gi 1343911068  3041 DNSP 3044
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
170-264 2.06e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 2.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  170 YSVTIAESTPLRTSIAQVTATDADIGSNGEFYFFFKEKV--DLFAVHPTSGVVYLSGKLNVDEQTLYNLEILAVDRgmkl 247
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*..
gi 1343911068  248 yGNNGVSSTAKLFVHVE 264
Cdd:pfam00028   77 -GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2199-2270 3.42e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 3.42e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343911068 2199 YSVYVNEDVEVYTPIISINST---SPEGQKIIYTIVDGDPSLQFDIGFDTGVISVIHCLDYEVTSSYHLTVRATD 2270
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1994-2088 4.47e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.03  E-value: 4.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1994 IYYSSIKENLPNITKVAVVSAV--GNHLNEPLKYSLL--NAGTHFRIRPTSGVIQTTGiPFDREEQEFYELIAEAKREHD 2069
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1343911068 2070 HRHVARVVVKVQVEDINDN 2088
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1911-1981 1.01e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 1.01e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343911068 1911 LQVSAIDPDKDVATELTFSLVDGS-LEHFDINPTSGIIVV-KNINF-SKELFRFTVQVSDG---KFSSSALVTLNVQ 1981
Cdd:cd11304     17 LTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTaKPLDReEQSSYTLTVTATDGggpPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 188-271 1.55e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.14  E-value: 1.55e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   188 TATDADIGSNGEFYFFFKEKVD--LFAVHPTSGVVYLSGKLNVDEQTLYNLEILAVDRGMKlygnnGVSSTAKLFVHVER 265
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-----PLSSTATVTITVLD 75


                    ....*.
gi 1343911068   266 LNEHAP 271
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2116-2187 2.01e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 2.01e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1343911068  2116 AVDGDKGVNGEVTYHLKYDHD--HFEINQKTGIISLKKSFESDlSNAEYQIVIYAKDGGDEPLSSTVEFPITVV 2187
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDRE-EQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
2097-2186 2.12e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 2.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2097 YYAVVQVDAEQGSHIFTVIAVDGDKGVNGEVTYHLKYDH--DHFEINQKTGIISLKKSFESDlSNAEYQIVIYAKDGGDE 2174
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1343911068 2175 PLSSTVEFPITV 2186
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3487-3567 2.13e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 2.13e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3487 SVIDRDSSRNGPpFSFQILSGNEGREFVL-KEDGTLTANQVFKREFATEYIIQIQVSDSGKPSLSSSTMLTVAVIEESLN 3565
Cdd:smart00112    1 SATDADSGENGK-VTYSILSGNDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1343911068  3566 RP 3567
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2425-2502 6.95e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 6.95e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  2425 QASDADSSDFDKLEYSILSGNERMHFVLEKSTGILALSSH--RKQKmdPTYSLNVSVSDG---VFTSTAQVHIKVLGANL 2499
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPldREEQ--PEYTLTVEATDGggpPLSSTATVTITVLDVND 78


                    ...
gi 1343911068  2500 HSP 2502
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2631-2707 1.31e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 1.31e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343911068  2631 QAHDLDDGSNAKVRYSLYSEarvPVVDILEIDPDNGWMVTKGSFSHLRNSVLSFFVKAVDGGIPARHSLVPVYIHVL 2707
Cdd:smart00112    1 SATDADSGENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
1375-1459 1.34e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 1.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1375 YNFTVMENDKVAEIVGVVSLQWSSAP----VWFDIRGGNSNSVFDVEKAVGTILIAKPLDAEQRSFYNLTVLATD-GTH- 1448
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPp 80

                           90
                   ....*....|..
gi 1343911068 1449 -TAYTQVHILVL 1459
Cdd:pfam00028   81 lSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2407-2495 5.82e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 5.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2407 YEAYVSELAPRGHFITCVQASDADSSDFDKLEYSILSGNERMHFVLEKSTGILALSSH--RKQKmdPTYSLNVSVSDGVF 2484
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPldRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1343911068 2485 ---TSTAQVHIKVL 2495
Cdd:pfam00028   79 pplSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2613-2707 6.36e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 6.36e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2613 YQASLKHDVTKGFLVTQLQAHDLDDGSNAKVRYSLyseARVPVVDILEIDPDNGWMVTKGSFSHLRNSVLSFFVKAVDGG 2692
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1343911068 2693 IPARHSLVPVYIHVL 2707
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 53-160 2.99e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.94  E-value: 2.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   53 VYHATIYENSAArtyaNSKIkmgITLDKRFLD------IRYRIVSGDEEGFFKAEEYvLGDfcflrIRTKGGnsaiLNRE 126
Cdd:cd11304      1 SYEVSVPENAPP----GTVV---LTVSATDPDsgengeVTYSIVSGNEDGLFSIDPS-TGE-----ITTAKP----LDRE 63

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1343911068  127 IQSNYVLTVKAFVKGEVFLEAWTKVSVQVLDMND 160
Cdd:cd11304     64 EQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3573-3644 6.59e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.17  E-value: 6.59e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343911068 3573 EIHVVTMEDEFPGGVIGQLHATDAD--PYDALTFGHAPQAQHGLFKISPHDGRIIALGGLDA---GSYSLNVTVSDG 3644
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDReeqSSYTLTVTATDG 77
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 385-472 1.44e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.44e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  385 YEIAINEVSPPRTVVCAVKIR----PEHENVEYILMPSKDLDFFQINTFTGVISTTRWLTKVSNNLFNLEVVeiSSDL-- 458
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT--ATDGgg 79

                           90
                   ....*....|....*....
gi 1343911068  459 -----RVKVLITIEDANDN 472
Cdd:cd11304     80 pplssTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
588-675 1.56e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 1.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  588 QGVISADFPVGEVITTVSAIDIDE--LELVKYKILSGNEQRLFDLNPDSGVLTLGHPLTSlgPQKGVFSLKITATD--GE 663
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDR--ESIGEYELTVEATDsgGP 79

                           90
                   ....*....|..
gi 1343911068  664 NLSDHMYVNISV 675
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 84-163 2.66e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 2.66e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068    84 DIRYRIVSGDEEGFFkaeeyvlgdfcflRIRTKGGN---SAILNREIQSNYVLTVKAFVKGEVFLEAWTKVSVQVLDMND 160
Cdd:smart00112   12 KVTYSILSGNDDGLF-------------SIDPETGEittTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1343911068   161 LRP 163
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
2721-2817 4.92e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 4.92e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2721 YSFNIPENTPIGSVIGTVRVSIPPEYSSLTATFATANGESGENnremvFLVEKDTGVIKLDKALDHEAIKEFYFKVTATV 2800
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 1343911068 2801 KQAKLDSmTSANVKVNV 2817
Cdd:pfam00028   76 SGGPPLS-STATVTITV 91
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4047-4082 5.01e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 5.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1343911068 4047 DPCL-HQPCHNGATCNSLPsGGFSCSCSHQFTGGNCE 4082
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
1995-2065 5.70e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 5.70e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343911068 1995 YYSSIKENLPNITKVAVVSAV----GnhLNEPLKYSLL--NAGTHFRIRPTSGVIQTTGiPFDREEQEFYELIAEAK 2065
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlG--PNGRIFYSILggGPGGNFRIDPDTGDISTTK-PLDRESIGEYELTVEAT 74
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4126-4160 5.79e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 51.23  E-value: 5.79e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1343911068 4126 CDRNNpegeCENGGTCVNTPGSFYCNCTPGFVGQR 4160
Cdd:pfam00008    1 CAPNP----CSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin pfam00028
Cadherin domain;
2946-3036 1.62e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2946 YIGTVRESDPPGEVVAVLNTRDEDSSVvNQHISIHITGGNDRGVFALRLVQGEwkMYVKGPLDREKRNFYLINITATDGL 3025
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRIDPDTGD--ISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|..
gi 1343911068 3026 FVSQTKV-EVTV 3036
Cdd:pfam00028   78 GPPLSSTaTVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2762-2825 1.67e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 1.67e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1343911068  2762 ENNREMVFLVEKDTGVIKLDKALDHEAIKEFYFKVTATVKQAKLDSmTSANVKVNVFDINDNRP 2825
Cdd:smart00112   19 SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS-STATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 605-676 3.62e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 3.62e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1343911068   605 SAIDIDELE--LVKYKILSGNEQRLFDLNPDSGVLTLGHPLTSlgPQKGVFSLKITATDGEN--LSDHMYVNISVV 676
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDR--EEQPEYTLTVEATDGGGppLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1914-1985 4.15e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 4.15e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1343911068  1914 SAIDPDKDVATELTFSLVDGS-LEHFDINPTSGIIVV-KNINF-SKELFRFTVQVSDG---KFSSSALVTLNVQEALD 1985
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTtKPLDReEQPEYTLTVEATDGggpPLSSTATVTITVLDVND 78
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4090-4120 4.67e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 4.67e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1343911068 4090 PNPCQNSGVCKPIGNAFLCSCRRGFRGLVCE 4120
Cdd:cd00054      8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2020-2090 7.38e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 7.38e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1343911068  2020 NEPLKYSLL--NAGTHFRIRPTSGVIQTTGiPFDREEQEFYELIAEAKREHDHRHVARVVVKVQVEDINDNFP 2090
Cdd:smart00112   10 NGKVTYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 265-368 3.86e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.08  E-value: 3.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  265 RLNEHAPVISAVTHhdsklykslayaiVNVDDSDEGVNGEIdSVIIVDGDPLGQFFLEktkENEYAIKATESINWESFPF 344
Cdd:cd11304      5 SVPENAPPGTVVLT-------------VSATDPDSGENGEV-TYSIVSGNEDGLFSID---PSTGEITTAKPLDREEQSS 67

                           90       100
                   ....*....|....*....|....
gi 1343911068  345 gCNITLQAKDRGIPPKLSTFPVHI 368
Cdd:cd11304     68 -YTLTVTATDGGGPPLSSTATVTI 90
EGF_CA smart00179
Calcium-binding EGF-like domain;
4047-4082 1.19e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 1.19e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1343911068  4047 DPCL-HQPCHNGATCNSLPsGGFSCSCSHQFT-GGNCE 4082
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4088-4116 1.58e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 44.30  E-value: 1.58e-05
                           10        20
                   ....*....|....*....|....*....
gi 1343911068 4088 CVPNPCQNSGVCKPIGNAFLCSCRRGFRG 4116
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4049-4078 1.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 1.70e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1343911068 4049 CLHQPCHNGATCNSLPsGGFSCSCSHQFTG 4078
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTG 29
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 410-474 1.86e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 1.86e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   410 NVEYILMPSKDLDFFQINTFTGVISTTRWLTKVSNNLFNLEVV-----EISSDLRVKVLITIEDANDNTP 474
Cdd:smart00112   12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEatdggGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
54-156 1.12e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.13  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   54 YHATIYENSAARTyanSKIKMGITlDKrflD------IRYRIVSGDEEGFFKAEEYvLGDfcflrIRTKggnsAILNREI 127
Cdd:pfam00028    1 YSASVPENAPVGT---EVLTVTAT-DP---DlgpngrIFYSILGGGPGGNFRIDPD-TGD-----ISTT----KPLDRES 63

                           90       100
                   ....*....|....*....|....*....
gi 1343911068  128 QSNYVLTVKAFVKGEVFLEAWTKVSVQVL 156
Cdd:pfam00028   64 IGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 293-368 1.18e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.80  E-value: 1.18e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1343911068   293 NVDDSDEGVNGEIdSVIIVDGDPLGQFFLEKTKEneyAIKATESINWESFPFgCNITLQAKDRGIPPKLSTFPVHI 368
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETG---EITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTATVTI 71
EGF smart00181
Epidermal growth factor-like domain;
4090-4120 2.84e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.27  E-value: 2.84e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1343911068  4090 PNPCQNsGVCKPIGNAFLCSCRRGFRGLV-CE 4120
Cdd:smart00181    5 GGPCSN-GTCINTPGSYTCSCPPGYTGDKrCE 35
Cadherin pfam00028
Cadherin domain;
3574-3644 4.72e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 4.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3574 IHVVTMEDEFPGGVIGQLHATDAD------PYDALTFGHAPqaqhGLFKISPHDGRIIALGGLDA---GSYSLNVTVSDG 3644
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlgpngrIFYSILGGGPG----GNFRIDPDTGDISTTKPLDResiGEYELTVEATDS 76
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3261-3355 3.21e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 130.90  E-value: 3.21e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3261 TTVPEDVRVGTEVLRVYAASKDIGTNAEITYTIRSGNEHRRFHVHPHSGAIIVAQPLDYETCRDYFLTVEARDGGTPPLS 3340
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1343911068 3341 AVTTVNINLTDVNDN 3355
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3364-3460 1.04e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 129.74  E-value: 1.04e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3364 YTAFVSEDAFIGEFVVQLVAEDSDSHLNGAVLYSVVSGDQGSQFFIDPINGVIKVNKPLDRETIPSFSLTIRALDSGVPP 3443
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 3444 MSSTALVNIDVSDVNDN 3460
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1054-1149 3.96e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 3.96e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1054 TGVVKENARIGTTLLQVSANDDDTGRDGEIHYSIRDGSGLGRFSIDEETGVIYTTDILDRETKDSYWLTVYASDRGVVPQ 1133
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1343911068 1134 FTTIDVFVQVEDINDN 1149
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1158-1258 6.18e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 6.18e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1158 YRPSVPENSPPDVSVIQIQAQDPDTSPStslHWLSYQIVSGNPQHFFNMDPHSGLITTTShKLDRELQTEHVLEVVISDG 1237
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGEN---GEVTYSIVSGNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1343911068 1238 GPNPRQSTVLVIVQVLDENDN 1258
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2299-2398 1.55e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.80  E-value: 1.55e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2299 SYSVSLSETAMIGTPVLQVIASDQDSEKNNIIRYQIFSQlhNSTDYFHIDSSSGLILTARMLDHELAHNYYFVVRATDNG 2378
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1343911068 2379 YPALSSEVTVTVTLNDMNDN 2398
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3050-3144 3.44e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 3.44e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3050 VYTASIPEDLPVHSLLLTVGATDADVGVNAQIQYSLHGSGSQD-FSIDPDTGEVKSLVTLDHEKTPSYRLVVQAMDGGG- 3127
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1343911068 3128 -QWCSAEIQLVVTDVNDN 3144
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 841-936 5.13e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 5.13e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  841 YKITIPENMAIGTDIIQVEATDKDMGPNGEVMYSILTSTT--PFGINSTTGMVYVAAQLDRELTSRFTLKIEARDRADKe 918
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP- 80

                           90
                   ....*....|....*...
gi 1343911068  919 sPKFSVTTLEIILEDVND 936
Cdd:cd11304     81 -PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 480-578 5.54e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 5.54e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  480 SYEVFVNESVPVGTNVLTVSATDEDRGENGYITYSISSLQPL-PFKIDQFSGVISTSSLLDFEsSTEIFVFLVRASDWGS 558
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDRE-EQSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 1343911068  559 PyRRESEVNVTIHLENVNDN 578
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3152-3250 9.55e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 9.55e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3152 QYTANVYENTIPKALLTRIQAIDPDEaGPGRMVVYSLT-DSAGGLFSIDHVSGVVILEHTLDREVQSTYQITVCASDQGS 3230
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90       100
                   ....*....|....*....|
gi 1343911068 3231 PlPLYSLVNVTITVLDINDN 3250
Cdd:cd11304     80 P-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1473-1570 2.25e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.55  E-value: 2.25e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1473 YEVTISEDTPTDTEVLQIVASDRDE--HNELTYSLQSsidPNSMRLFRIHPTLGTIFTTQRLDHEACAQHILTVLVKDQD 1550
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVS---GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1343911068 1551 FPYRKNLARVLIEVEDINDH 1570
Cdd:cd11304     79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3382-3462 3.10e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 107.82  E-value: 3.10e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3382 VAEDSDSHLNGAVLYSVVSGDQGSQFFIDPINGVIKVNKPLDRETIPSFSLTIRALDSGVPPMSSTALVNIDVSDVNDNP 3461
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1343911068  3462 P 3462
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3278-3357 8.96e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 106.28  E-value: 8.96e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3278 AASKDIGTNAEITYTIRSGNEHRRFHVHPHSGAIIVAQPLDYETCRDYFLTVEARDGGTPPLSAVTTVNINLTDVNDNAP 3357
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 737-831 1.90e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 1.90e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  737 IAVMEDLKIGSSVIKVNAYDGDTGFNGQVLFSFSGGNTDNCFNIDMQTGLISVFLPMDREKRDHYLLNITIYDLGIPQKM 816
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1343911068  817 AWRLLSIHIEDANDN 831
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 952-1042 2.68e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 2.68e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  952 EDLPVGTVVAWLETHDPDLGLGGQVRFSLV-NDHNGWFELDKASGAIRLTKELDYETQQFYNLTVKAKDKGRPvSLLSVT 1030
Cdd:cd11304      8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSSTA 86

                           90
                   ....*....|..
gi 1343911068 1031 FVELEVIDVNEN 1042
Cdd:cd11304     87 TVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1579-1674 4.84e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.70  E-value: 4.84e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1579 YEGSVYESAAKGSAVVQVTALDKDKGKNAELRYSIEAGNTGNTFRIEPVLGIISVAHNLDLTNVGHYVVTVRVTDNGVPP 1658
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 1659 LSTNTVVRIAVT-LSDN 1674
Cdd:cd11304     82 LSSTATVTITVLdVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1071-1151 1.53e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.81  E-value: 1.53e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  1071 SANDDDTGRDGEIHYSIRDGSGLGRFSIDEETGVIYTTDILDRETKDSYWLTVYASDRGVVPQFTTIDVFVQVEDINDNA 1150
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1343911068  1151 P 1151
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2508-2604 3.84e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 3.84e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2508 VYEAELRENAAVGTTVIQVKATDKDQEPFGHITYSFANDVGSDQFSIDSN-GYICTVEKLDREDPANrdILLIVAAQDLG 2586
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSS--YTLTVTATDGG 78

                           90       100
                   ....*....|....*....|
gi 1343911068 2587 G--RVSYCTVQITLLDDNDN 2604
Cdd:cd11304     79 GppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3262-3350 4.45e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.99  E-value: 4.45e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3262 TVPEDVRVGTEVLRVYAASKDIGTNAEITYTIRSGNEHRRFHVHPHSGAIIVAQPLDYETCRDYFLTVEARDGGTPPLSA 3341
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1343911068 3342 VTTVNINLT 3350
Cdd:pfam00028   84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3364-3454 6.37e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.61  E-value: 6.37e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3364 YTAFVSEDAFIGEFVVQLVAEDSDSHLNGAVLYSVVSGDQGSQFFIDPINGVIKVNKPLDRETIPSFSLTIRALDSGVPP 3443
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 1343911068 3444 MSSTALVNIDV 3454
Cdd:pfam00028   81 LSSTATVTITV 91
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 3856-4016 1.26e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 102.88  E-value: 1.26e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3856 SLSFSGNSYIKYRLSERLQTELKLSLRIRTLQSHGIIMSMHTEHC---ILLKLVDGKLWFQLACGLGAGGSSpdilglSG 3932
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGgdfLALELEDGRLVLRYDLGSGSLVLS------SK 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3933 HRINDGNWHTVALEMNRNFSRLALDNSFIEQRHAPSLMQTHFQERTIYLGALvqPPNSRslvdsQRDLRVHDGFQGCLDL 4012
Cdd:cd00110     75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGL--PEDLK-----SPGLPVSPGFVGCIRD 147


                   ....
gi 1343911068 4013 VTLN 4016
Cdd:cd00110    148 LKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1683-1773 3.13e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.70  E-value: 3.13e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1683 EYQTEVSENALIGTSITTVSAFSQ-----STLIYDIKQGNAEHVFQINQYSGVITNQKALDYETTESYTLIVQAVNMAG- 1756
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPdsgenGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 1343911068 1757 -MASNATLLIQILDENDN 1773
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1781-1886 7.43e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.54  E-value: 7.43e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1781 HYYGSISEVAPVKSVVLNLHglplvirATDPDHNQNALLVYEIVENTAKKVFTVDSGTGSIRTIANLDHETFPIFIFHVQ 1860
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVS-------ATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT 73

                           90       100
                   ....*....|....*....|....*.
gi 1343911068 1861 VRDSGRPQLTadSPTEVTIQVIDSND 1886
Cdd:cd11304     74 ATDGGGPPLS--STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2831-2916 3.10e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 3.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2831 SYVATVMEGTAVGTKVIRVQASDPDSGANGQVTYRLgslikskgNSEPLSDIFNIDSNSGWIFIRTDLDHETSPFYTFTV 2910
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI--------VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTV 72


                   ....*.
gi 1343911068 2911 VALDHG 2916
Cdd:cd11304     73 TATDGG 78
Cadherin pfam00028
Cadherin domain;
1161-1253 3.57e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.52  E-value: 3.57e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1161 SVPENSPPDVSVIQIQAQDPDTSPSTSLhwlSYQIVSGNPQHFFNMDPHSGLITTTSHkLDRELQTEHVLEVVISDGGPN 1240
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRI---FYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1343911068 1241 PRQSTVLVIVQVL 1253
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3070-3146 4.21e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 4.21e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3070 ATDADVGVNAQIQYSLHGSGSQD-FSIDPDTGEVKSLVTLDHEKTPSYRLVVQAMDGGGQ--WCSAEIQLVVTDVNDNPP 3146
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2319-2400 5.53e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.80  E-value: 5.53e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  2319 ASDQDSEKNNIIRYQIFSQlhNSTDYFHIDSSSGLILTARMLDHELAHNYYFVVRATDNGYPALSSEVTVTVTLNDMNDN 2398
Cdd:smart00112    2 ATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1343911068  2399 AP 2400
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-269 6.63e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 6.63e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  169 TYSVTIAESTPLRTSIAQVTATDADIGSNGEFYFFFKE--KVDLFAVHPTSGVVYLSGKLNVDEQTLYNLEILAVDRgmk 246
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1343911068  247 lyGNNGVSSTAKLFVHVERLNEH 269
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1054-1144 1.83e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.59  E-value: 1.83e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1054 TGVVKENARIGTTLLQVSANDDDTGRDGEIHYSIRDGSGLGRFSIDEETGVIYTTDILDRETKDSYWLTVYASDRGVVPQ 1133
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1343911068 1134 FTTIDVFVQVE 1144
Cdd:pfam00028   82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1176-1260 2.60e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 2.60e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  1176 QAQDPDTSPStslHWLSYQIVSGNPQHFFNMDPHSGLITTTsHKLDRELQTEHVLEVVISDGGPNPRQSTVLVIVQVLDE 1255
Cdd:smart00112    1 SATDADSGEN---GKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                    ....*
gi 1343911068  1256 NDNKP 1260
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
1579-1670 2.89e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.21  E-value: 2.89e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1579 YEGSVYESAAKGSAVVQVTALDKDKGKNAELRYSIEAGNTGNTFRIEPVLGIISVAHNLDLTNVGHYVVTVRVTDNGVPP 1658
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1343911068 1659 LSTNTVVRIAVT 1670
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3171-3252 1.63e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 1.63e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3171 QAIDPDEaGPGRMVVYSLTD-SAGGLFSIDHVSGVVILEHTLDREVQSTYQITVCASDQGSPlPLYSLVNVTITVLDIND 3249
Cdd:smart00112    1 SATDADS-GENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1343911068  3250 NHP 3252
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 753-833 8.30e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.63  E-value: 8.30e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   753 NAYDGDTGFNGQVLFSFSGGNTDNCFNIDMQTGLISVFLPMDREKRDHYLLNITIYDLGIPQKMAWRLLSIHIEDANDNA 832
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1343911068   833 P 833
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2096-2187 1.08e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 1.08e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2096 PYYAVVQVDAEQGSHIFTVIAVDGDKGVNGEVTYHLKYDHD--HFEINQKTGIISLKKS--FEsdlSNAEYQIVIYAKDG 2171
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPldRE---EQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1343911068 2172 GDEPLSSTVEFPITVV 2187
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2945-3042 1.73e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 1.73e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2945 HYIGTVRESDPPGEVVAVLNTRDEDSSVvNQHISIHITGGNDRGVFALRLVQGEwkMYVKGPLDREKRNFYLINITATDG 3024
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGE-NGEVTYSIVSGNEDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1343911068 3025 ---LFVSQTKVEVTVMDANDN 3042
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2407-2500 1.96e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 1.96e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2407 YEAYVSELAPRGHFITCVQASDADSSDFDKLEYSILSGNERMHFVLEKSTGILALsshrKQKMD----PTYSLNVSVSDG 2482
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITT----AKPLDreeqSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1343911068 2483 ---VFTSTAQVHIKVLGANLH 2500
Cdd:cd11304     78 ggpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1807-1889 2.03e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.48  E-value: 2.03e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  1807 RATDPDHNQNALLVYEIVENTAKKVFTVDSGTGSIRTIANLDHETFPIFIFHVQVRDSGRPQLTadSPTEVTIQVIDSND 1886
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS--STATVTITVLDVND 78


                    ...
gi 1343911068  1887 SPP 1889
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
3051-3139 3.47e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 3.47e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3051 YTASIPEDLPVHSLLLTVGATDADVGVNAQIQYSLHGSGS-QDFSIDPDTGEVKSLVTLDHEKTPSYRLVVQAMDGGGQW 3129
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|
gi 1343911068 3130 CSAEIQLVVT 3139
Cdd:pfam00028   81 LSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 966-1042 3.51e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 84.71  E-value: 3.51e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1343911068   966 HDPDLGLGGQVRFSLV-NDHNGWFELDKASGAIRLTKELDYETQQFYNLTVKAKDKGRPvSLLSVTFVELEVIDVNEN 1042
Cdd:smart00112    3 TDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2199-2291 4.02e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 4.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2199 YSVYVNEDVEVYTPIISINST---SPEGQKIIYTIVDGDPSLQFDIGFDTGVISVIHCLDYEVTSSYHLTVRATD-YLTG 2274
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 2275 AHAEVDLGVFIQDINDN 2291
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 499-580 6.17e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 6.17e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   499 SATDEDRGENGYITYSISSLQP-LPFKIDQFSGVISTSSLLDFEsSTEIFVFLVRASDWGSPyRRESEVNVTIHLENVND 577
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTTKPLDRE-EQPEYTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1343911068   578 NQP 580
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1266-1356 6.23e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 84.67  E-value: 6.23e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1266 VYKVKLPERERRKkaEPIYRVFAYDLDEGPNSDISYSIVDGNEDGKFVIDPKTGTVQSRRAFPAGGYD--ILTIKATDNG 1343
Cdd:cd11304      1 SYEVSVPENAPPG--TVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSsyTLTVTATDGG 78

                           90
                   ....*....|...
gi 1343911068 1344 RPQKSSTARLHIE 1356
Cdd:cd11304     79 GPPLSSTATVTIT 91
Cadherin pfam00028
Cadherin domain;
841-932 7.85e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.27  E-value: 7.85e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  841 YKITIPENMAIGTDIIQVEATDKDMGPNGEVMYSILTSTTP--FGINSTTGMVYVAAQLDRELTSRFTLKIEARDRADKe 918
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP- 79

                           90
                   ....*....|....
gi 1343911068  919 sPKFSVTTLEIILE 932
Cdd:pfam00028   80 -PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 860-939 2.08e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 2.08e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   860 ATDKDMGPNGEVMYSILTSTT--PFGINSTTGMVYVAAQLDRELTSRFTLKIEARDRAdkESPKFSVTTLEIILEDVNDC 937
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1343911068   938 SP 939
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3470-3565 2.43e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 2.43e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3470 TAVIQENKPIGTTILQLSVIDRDSSRNGpPFSFQILSGNEGREFVL-KEDGTLTANQVFKREFATEYIIQIQVSDSGKPS 3548
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 1343911068 3549 LSSSTMLTVAVIEESLN 3565
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2832-2917 2.75e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 2.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2832 YVATVMEGTAVGTKVIRVQASDPDSGANGQVTYRLgslikSKGNSeplSDIFNIDSNSGWIFIRTDLDHETSPFYTFTVV 2911
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI-----LGGGP---GGNFRIDPDTGDISTTKPLDRESIGEYELTVE 72


                   ....*.
gi 1343911068 2912 ALDHGE 2917
Cdd:pfam00028   73 ATDSGG 78
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 3883-4018 2.94e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 83.62  E-value: 2.94e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3883 IRTLQSHGIIMSMHTE--HCILLKLVDGKLWFQLACGlgaggSSPDILGLSGHRINDGNWHTVALEMNRNFSRLALDNSF 3960
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGgsDFLALELVNGRLVLRYDLG-----SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1343911068 3961 IEQRHAPSLMQTHFQERTIYLGALVQPPNSRSLVdsqrdlrVHDGFQGCLDLVTLNDN 4018
Cdd:pfam02210   76 VVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALP-------VRAGFVGCIRDVRVNGE 126
Cadherin pfam00028
Cadherin domain;
2300-2392 3.01e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 3.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2300 YSVSLSETAMIGTPVLQVIASDQDSEKNNIIRYQIFSqlHNSTDYFHIDSSSGLILTARMLDHELAHNYYFVVRATDNGY 2379
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILG--GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|...
gi 1343911068 2380 PALSSEVTVTVTL 2392
Cdd:pfam00028   79 PPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
952-1023 7.58e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.19  E-value: 7.58e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1343911068  952 EDLPVGTVVAWLETHDPDLGLGGQVRFSLVNDH-NGWFELDKASGAIRLTKELDYETQQFYNLTVKAKDKGRP 1023
Cdd:pfam00028    7 ENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
2509-2599 1.20e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.81  E-value: 1.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2509 YEAELRENAAVGTTVIQVKATDKDQEPFGHITYSFANDVGSDQFSID-SNGYICTVEKLDREdpANRDILLIVAAQDLG- 2586
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRE--SIGEYELTVEATDSGg 78

                           90
                   ....*....|....
gi 1343911068 2587 -GRVSYCTVQITLL 2599
Cdd:pfam00028   79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1707-1775 1.24e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.24e-17
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1343911068  1707 STLIYDIKQGNAEHVFQINQYSGVITNQKALDYETTESYTLIVQAVNMAG--MASNATLLIQILDENDNPP 1775
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1375-1464 1.52e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 80.82  E-value: 1.52e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1375 YNFTVMENDKVAEIVGVVSLQW----SSAPVWFDIRGGNSNSVFDVEKAVGTILIAKPLDAEQRSFYNLTVLATDG---T 1447
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDpdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpP 81

                           90
                   ....*....|....*..
gi 1343911068 1448 HTAYTQVHILVLDNNDN 1464
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3153-3245 3.56e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 3.56e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3153 YTANVYENTIPKALLTRIQAIDPDEaGPGRMVVYSLT-DSAGGLFSIDHVSGVVILEHTLDREVQSTYQITVCASDQGSP 3231
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDL-GPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|....
gi 1343911068 3232 lPLYSLVNVTITVL 3245
Cdd:pfam00028   80 -PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2612-2707 3.82e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 79.66  E-value: 3.82e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2612 EYQASLKHDVTKGFLVTQLQAHDLDDGSNAKVRYSLYSEarvPVVDILEIDPDNGWMVTKGSFSHLRNSVLSFFVKAVDG 2691
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG---NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90
                   ....*....|....*.
gi 1343911068 2692 GIPARHSLVPVYIHVL 2707
Cdd:cd11304     78 GGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
481-573 1.42e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 1.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  481 YEVFVNESVPVGTNVLTVSATDEDRGENGYITYSISS-LQPLPFKIDQFSGVISTSSLLDFEsSTEIFVFLVRASDWGSP 559
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|....
gi 1343911068  560 YrRESEVNVTIHLE 573
Cdd:pfam00028   80 P-LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1684-1768 1.60e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 77.73  E-value: 1.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1684 YQTEVSENALIGTSITTVSAFS-----QSTLIYDIKQGNAEHVFQINQYSGVITNQKALDYETTESYTLIVQAVNMA--G 1756
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 1343911068 1757 MASNATLLIQIL 1768
Cdd:pfam00028   81 LSSTATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4122-4161 1.68e-16

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 75.75  E-value: 1.68e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1343911068 4122 DVNECDRNNPegeCENGGTCVNTPGSFYCNCTPGFVGQRC 4161
Cdd:cd00054      1 DIDECASGNP---CQNGGTCVNTVGSYRCSCPPGYTGRNC 37
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1597-1670 1.86e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 1.86e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1343911068  1597 TALDKDKGKNAELRYSIEAGNTGNTFRIEPVLGIISVAHNLDLTNVGHYVVTVRVTDNGVPPLSTNTVVRIAVT 1670
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2220-2293 6.28e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 6.28e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343911068  2220 SPEGQKIIYTIVDGDPSLQFDIGFDTGVISVIHCLDYEVTSSYHLTVRATDYLTGAH-AEVDLGVFIQDINDNPP 2293
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLsSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1473-1565 7.21e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.80  E-value: 7.21e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1473 YEVTISEDTPTDTEVLQIVASDRDE--HNELTYSLQSsidPNSMRLFRIHPTLGTIFTTQRLDHEACAQHILTVLVKDQD 1550
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILG---GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1343911068 1551 FPYRKNLARVLIEVE 1565
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1267-1356 9.20e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.41  E-value: 9.20e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1267 YKVKLPERERRKKaePIYRVFAYDLDEGPNSDISYSIVDGNEDGKFVIDPKTGTVQSRRA--FPAGGYDILTIKATDNGR 1344
Cdd:pfam00028    1 YSASVPENAPVGT--EVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPldRESIGEYELTVEATDSGG 78

                           90
                   ....*....|..
gi 1343911068 1345 PQKSSTARLHIE 1356
Cdd:pfam00028   79 PPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2527-2606 1.62e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 74.31  E-value: 1.62e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  2527 KATDKDQEPFGHITYSFANDVGSDQFSIDSN-GYICTVEKLDREDPANrdILLIVAAQDLGG--RVSYCTVQITLLDDND 2603
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPE--YTLTVEATDGGGppLSSTATVTITVLDVND 78


                    ...
gi 1343911068  2604 NSP 2606
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
1782-1882 2.44e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 2.44e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1782 YYGSISEVAPVKSVVLNLHglplvirATDPDHNQNALLVYEIVENTAKKVFTVDSGTGSIRTIANLDHETFPIFIFHVQV 1861
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVT-------ATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90       100
                   ....*....|....*....|.
gi 1343911068 1862 RDSGRPQLTadSPTEVTIQVI 1882
Cdd:pfam00028   74 TDSGGPPLS--STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2720-2823 4.08e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 4.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2720 HYSFNIPENTPIGSVIGTVRVSIPPEYSSLTATFATANGESGEnnremVFLVEKDTGVIKLDKALDHEAIKEFYFKVTAT 2799
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-----LFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 1343911068 2800 vKQAKLDSMTSANVKVNVFDINDN 2823
Cdd:cd11304     76 -DGGGPPLSSTATVTITVLDVNDN 98
LamG smart00282
Laminin G domain;
3878-4018 4.23e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 75.07  E-value: 4.23e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3878 KLSLRIRTLQSHGIIMSMH----TEHcILLKLVDGKLWFQLACGlgaggSSPDILGLSGHRINDGNWHTVALEMNRNFSR 3953
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGskggGDY-LALELRDGRLVLRYDLG-----SGPARLTSDPTPLNDGQWHRVAVERNGRSVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343911068  3954 LALDNSFIEQRHAPSLMQTHFQERTIYLGALvqPPNSRslvdsQRDLRVHDGFQGCLDLVTLNDN 4018
Cdd:smart00282   75 LSVDGGNRVSGESPGGLTILNLDGPLYLGGL--PEDLK-----LPPLPVTPGFRGCIRNLKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1491-1572 4.28e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 4.28e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  1491 VASDRDE--HNELTYSLqssIDPNSMRLFRIHPTLGTIFTTQRLDHEACAQHILTVLVKDQDFPYRKNLARVLIEVEDIN 1568
Cdd:smart00112    1 SATDADSgeNGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1343911068  1569 DHVP 1572
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
3470-3560 6.33e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 6.33e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3470 TAVIQENKPIGTTILQLSVIDRDSSRNGPPFsFQILSGNEGREFVL-KEDGTLTANQVFKREFATEYIIQIQVSDSGKPS 3548
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIF-YSILGGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1343911068 3549 LSSSTMLTVAVI 3560
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2850-2939 6.45e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 6.45e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  2850 QASDPDSGANGQVTYRLgslikskgNSEPLSDIFNIDSNSGWIFIRTDLDHETSPFYTFTVVALDHGEvLSLSSTTTVTV 2929
Cdd:smart00112    1 SATDADSGENGKVTYSI--------LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG-PPLSSTATVTI 71

                            90
                    ....*....|
gi 1343911068  2930 TVSDVNDNAP 2939
Cdd:smart00112   72 TVLDVNDNAP 81
EGF_CA smart00179
Calcium-binding EGF-like domain;
4122-4161 1.32e-14

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 70.35  E-value: 1.32e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1343911068  4122 DVNECDRNNPegeCENGGTCVNTPGSFYCNCTPGFV-GQRC 4161
Cdd:smart00179    1 DIDECASGNP---CQNGGTCVNTVGSYRCECPPGYTdGRNC 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1288-1356 7.82e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 7.82e-14
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1343911068  1288 AYDLDEGPNSDISYSIVDGNEDGKFVIDPKTGTVQSRRAF---PAGGYDiLTIKATDNGRPQKSSTARLHIE 1356
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 591-676 9.36e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.03  E-value: 9.36e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  591 ISADFPVGEVITTVSAIDIDELE--LVKYKILSGNEQRLFDLNPDSGVLTLGHPLTSlgPQKGVFSLKITATDGEN--LS 666
Cdd:cd11304      6 VPENAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDR--EEQSSYTLTVTATDGGGppLS 83

                           90
                   ....*....|
gi 1343911068  667 DHMYVNISVV 676
Cdd:cd11304     84 STATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1397-1466 1.90e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 1.90e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1343911068  1397 SSAPVWFDIRGGNSNSVFDVEKAVGTILIAKPLDAEQRSFYNLTVLATDG---THTAYTQVHILVLDNNDNDP 1466
Cdd:smart00112    9 ENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
737-826 1.91e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.87  E-value: 1.91e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  737 IAVMEDLKIGSSVIKVNAYDGDTGFNGQVLFSFSGGNTDNCFNIDMQTGLISVFLPMDREKRDHYLLNITIYDLGIPQKM 816
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1343911068  817 AWRLLSIHIE 826
Cdd:pfam00028   83 STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2964-3044 1.56e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 65.83  E-value: 1.56e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  2964 NTRDEDSSVvNQHISIHITGGNDRGVFALRLVQGEwkMYVKGPLDREKRNFYLINITATDG---LFVSQTKVEVTVMDAN 3040
Cdd:smart00112    1 SATDADSGE-NGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVN 77


                    ....
gi 1343911068  3041 DNSP 3044
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
170-264 2.06e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 2.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  170 YSVTIAESTPLRTSIAQVTATDADIGSNGEFYFFFKEKV--DLFAVHPTSGVVYLSGKLNVDEQTLYNLEILAVDRgmkl 247
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*..
gi 1343911068  248 yGNNGVSSTAKLFVHVE 264
Cdd:pfam00028   77 -GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2199-2270 3.42e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.40  E-value: 3.42e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343911068 2199 YSVYVNEDVEVYTPIISINST---SPEGQKIIYTIVDGDPSLQFDIGFDTGVISVIHCLDYEVTSSYHLTVRATD 2270
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1994-2088 4.47e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.03  E-value: 4.47e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1994 IYYSSIKENLPNITKVAVVSAV--GNHLNEPLKYSLL--NAGTHFRIRPTSGVIQTTGiPFDREEQEFYELIAEAKREHD 2069
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATdpDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1343911068 2070 HRHVARVVVKVQVEDINDN 2088
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1911-1981 1.01e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 1.01e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343911068 1911 LQVSAIDPDKDVATELTFSLVDGS-LEHFDINPTSGIIVV-KNINF-SKELFRFTVQVSDG---KFSSSALVTLNVQ 1981
Cdd:cd11304     17 LTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTaKPLDReEQSSYTLTVTATDGggpPLSSTATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 188-271 1.55e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.14  E-value: 1.55e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   188 TATDADIGSNGEFYFFFKEKVD--LFAVHPTSGVVYLSGKLNVDEQTLYNLEILAVDRGMKlygnnGVSSTAKLFVHVER 265
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-----PLSSTATVTITVLD 75


                    ....*.
gi 1343911068   266 LNEHAP 271
Cdd:smart00112   76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2116-2187 2.01e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 2.01e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1343911068  2116 AVDGDKGVNGEVTYHLKYDHD--HFEINQKTGIISLKKSFESDlSNAEYQIVIYAKDGGDEPLSSTVEFPITVV 2187
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDRE-EQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
2097-2186 2.12e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 2.12e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2097 YYAVVQVDAEQGSHIFTVIAVDGDKGVNGEVTYHLKYDH--DHFEINQKTGIISLKKSFESDlSNAEYQIVIYAKDGGDE 2174
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|..
gi 1343911068 2175 PLSSTVEFPITV 2186
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3487-3567 2.13e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 62.75  E-value: 2.13e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  3487 SVIDRDSSRNGPpFSFQILSGNEGREFVL-KEDGTLTANQVFKREFATEYIIQIQVSDSGKPSLSSSTMLTVAVIEESLN 3565
Cdd:smart00112    1 SATDADSGENGK-VTYSILSGNDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1343911068  3566 RP 3567
Cdd:smart00112   80 AP 81
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4125-4161 5.16e-11

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 60.18  E-value: 5.16e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1343911068 4125 ECDRNNPegeCENGGTCVNTPGSFYCNCTPGFVGQ-RC 4161
Cdd:cd00053      1 ECAASNP---CSNGGTCVNTPGSYRCVCPPGYTGDrSC 35
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2425-2502 6.95e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.21  E-value: 6.95e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  2425 QASDADSSDFDKLEYSILSGNERMHFVLEKSTGILALSSH--RKQKmdPTYSLNVSVSDG---VFTSTAQVHIKVLGANL 2499
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPldREEQ--PEYTLTVEATDGggpPLSSTATVTITVLDVND 78


                    ...
gi 1343911068  2500 HSP 2502
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2631-2707 1.31e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 1.31e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343911068  2631 QAHDLDDGSNAKVRYSLYSEarvPVVDILEIDPDNGWMVTKGSFSHLRNSVLSFFVKAVDGGIPARHSLVPVYIHVL 2707
Cdd:smart00112    1 SATDADSGENGKVTYSILSG---NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
1375-1459 1.34e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 1.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 1375 YNFTVMENDKVAEIVGVVSLQWSSAP----VWFDIRGGNSNSVFDVEKAVGTILIAKPLDAEQRSFYNLTVLATD-GTH- 1448
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDsGGPp 80

                           90
                   ....*....|..
gi 1343911068 1449 -TAYTQVHILVL 1459
Cdd:pfam00028   81 lSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2407-2495 5.82e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 5.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2407 YEAYVSELAPRGHFITCVQASDADSSDFDKLEYSILSGNERMHFVLEKSTGILALSSH--RKQKmdPTYSLNVSVSDGVF 2484
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPldRESI--GEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 1343911068 2485 ---TSTAQVHIKVL 2495
Cdd:pfam00028   79 pplSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
2613-2707 6.36e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 6.36e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2613 YQASLKHDVTKGFLVTQLQAHDLDDGSNAKVRYSLyseARVPVVDILEIDPDNGWMVTKGSFSHLRNSVLSFFVKAVDGG 2692
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....*
gi 1343911068 2693 IPARHSLVPVYIHVL 2707
Cdd:pfam00028   78 GPPLSSTATVTITVL 92
Laminin_G_1 pfam00054
Laminin G domain;
3883-4020 1.93e-09

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 58.48  E-value: 1.93e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3883 IRTLQSHGIIMSMHTE---HCILLKLVDGKLWFQLACGLGAGGSSpdilglSGHRINDGNWHTVALEMN-RNFSrLALDN 3958
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQterDFLALELRDGRLEVSYDLGSGAAVVR------SGDKLNDGKWHSVELERNgRSGT-LSVDG 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1343911068 3959 ---SFIEQRHAPsLMQTHFqERTIYLGALvqPpnsrSLVDSQRDLRVHDGFQGCLDLVTLNDNEL 4020
Cdd:pfam00054   74 earPTGESPLGA-TTDLDV-DGPLYVGGL--P----SLGVKKRRLAISPSFDGCIRDVIVNGKPL 130
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 53-160 2.99e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.94  E-value: 2.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   53 VYHATIYENSAArtyaNSKIkmgITLDKRFLD------IRYRIVSGDEEGFFKAEEYvLGDfcflrIRTKGGnsaiLNRE 126
Cdd:cd11304      1 SYEVSVPENAPP----GTVV---LTVSATDPDsgengeVTYSIVSGNEDGLFSIDPS-TGE-----ITTAKP----LDRE 63

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1343911068  127 IQSNYVLTVKAFVKGEVFLEAWTKVSVQVLDMND 160
Cdd:cd11304     64 EQSSYTLTVTATDGGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3573-3644 6.59e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.17  E-value: 6.59e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343911068 3573 EIHVVTMEDEFPGGVIGQLHATDAD--PYDALTFGHAPQAQHGLFKISPHDGRIIALGGLDA---GSYSLNVTVSDG 3644
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDReeqSSYTLTVTATDG 77
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 385-472 1.44e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.44e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  385 YEIAINEVSPPRTVVCAVKIR----PEHENVEYILMPSKDLDFFQINTFTGVISTTRWLTKVSNNLFNLEVVeiSSDL-- 458
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVT--ATDGgg 79

                           90
                   ....*....|....*....
gi 1343911068  459 -----RVKVLITIEDANDN 472
Cdd:cd11304     80 pplssTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
588-675 1.56e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 55.00  E-value: 1.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  588 QGVISADFPVGEVITTVSAIDIDE--LELVKYKILSGNEQRLFDLNPDSGVLTLGHPLTSlgPQKGVFSLKITATD--GE 663
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDR--ESIGEYELTVEATDsgGP 79

                           90
                   ....*....|..
gi 1343911068  664 NLSDHMYVNISV 675
Cdd:pfam00028   80 PLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 84-163 2.66e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 2.66e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068    84 DIRYRIVSGDEEGFFkaeeyvlgdfcflRIRTKGGN---SAILNREIQSNYVLTVKAFVKGEVFLEAWTKVSVQVLDMND 160
Cdd:smart00112   12 KVTYSILSGNDDGLF-------------SIDPETGEittTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 1343911068   161 LRP 163
Cdd:smart00112   79 NAP 81
EGF smart00181
Epidermal growth factor-like domain;
4125-4162 4.62e-08

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 51.75  E-value: 4.62e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1343911068  4125 ECDRNNPegeCENGgTCVNTPGSFYCNCTPGFVGQ-RCS 4162
Cdd:smart00181    1 ECASGGP---CSNG-TCINTPGSYTCSCPPGYTGDkRCE 35
Cadherin pfam00028
Cadherin domain;
2721-2817 4.92e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.46  E-value: 4.92e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2721 YSFNIPENTPIGSVIGTVRVSIPPEYSSLTATFATANGESGENnremvFLVEKDTGVIKLDKALDHEAIKEFYFKVTATV 2800
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*..
gi 1343911068 2801 KQAKLDSmTSANVKVNV 2817
Cdd:pfam00028   76 SGGPPLS-STATVTITV 91
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4047-4082 5.01e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 5.01e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1343911068 4047 DPCL-HQPCHNGATCNSLPsGGFSCSCSHQFTGGNCE 4082
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
Cadherin pfam00028
Cadherin domain;
1995-2065 5.70e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 5.70e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1343911068 1995 YYSSIKENLPNITKVAVVSAV----GnhLNEPLKYSLL--NAGTHFRIRPTSGVIQTTGiPFDREEQEFYELIAEAK 2065
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATdpdlG--PNGRIFYSILggGPGGNFRIDPDTGDISTTK-PLDRESIGEYELTVEAT 74
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4126-4160 5.79e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 51.23  E-value: 5.79e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1343911068 4126 CDRNNpegeCENGGTCVNTPGSFYCNCTPGFVGQR 4160
Cdd:pfam00008    1 CAPNP----CSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin pfam00028
Cadherin domain;
2946-3036 1.62e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.92  E-value: 1.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2946 YIGTVRESDPPGEVVAVLNTRDEDSSVvNQHISIHITGGNDRGVFALRLVQGEwkMYVKGPLDREKRNFYLINITATDGL 3025
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP-NGRIFYSILGGGPGGNFRIDPDTGD--ISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|..
gi 1343911068 3026 FVSQTKV-EVTV 3036
Cdd:pfam00028   78 GPPLSSTaTVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2762-2825 1.67e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 1.67e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1343911068  2762 ENNREMVFLVEKDTGVIKLDKALDHEAIKEFYFKVTATVKQAKLDSmTSANVKVNVFDINDNRP 2825
Cdd:smart00112   19 SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS-STATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 605-676 3.62e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 3.62e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1343911068   605 SAIDIDELE--LVKYKILSGNEQRLFDLNPDSGVLTLGHPLTSlgPQKGVFSLKITATDGEN--LSDHMYVNISVV 676
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDR--EEQPEYTLTVEATDGGGppLSSTATVTITVL 74
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1914-1985 4.15e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.43  E-value: 4.15e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1343911068  1914 SAIDPDKDVATELTFSLVDGS-LEHFDINPTSGIIVV-KNINF-SKELFRFTVQVSDG---KFSSSALVTLNVQEALD 1985
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTtKPLDReEQPEYTLTVEATDGggpPLSSTATVTITVLDVND 78
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4090-4120 4.67e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 4.67e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1343911068 4090 PNPCQNSGVCKPIGNAFLCSCRRGFRGLVCE 4120
Cdd:cd00054      8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2020-2090 7.38e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 7.38e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1343911068  2020 NEPLKYSLL--NAGTHFRIRPTSGVIQTTGiPFDREEQEFYELIAEAKREHDHRHVARVVVKVQVEDINDNFP 2090
Cdd:smart00112   10 NGKVTYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
EGF_CA pfam07645
Calcium-binding EGF domain;
4122-4155 2.35e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.85  E-value: 2.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1343911068 4122 DVNECD--RNNpegeCENGGTCVNTPGSFYCNCTPG 4155
Cdd:pfam07645    1 DVDECAtgTHN----CPANTVCVNTIGSFECRCPDG 32
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 265-368 3.86e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.08  E-value: 3.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068  265 RLNEHAPVISAVTHhdsklykslayaiVNVDDSDEGVNGEIdSVIIVDGDPLGQFFLEktkENEYAIKATESINWESFPF 344
Cdd:cd11304      5 SVPENAPPGTVVLT-------------VSATDPDSGENGEV-TYSIVSGNEDGLFSID---PSTGEITTAKPLDREEQSS 67

                           90       100
                   ....*....|....*....|....
gi 1343911068  345 gCNITLQAKDRGIPPKLSTFPVHI 368
Cdd:cd11304     68 -YTLTVTATDGGGPPLSSTATVTI 90
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 4135-4156 8.69e-06

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 45.02  E-value: 8.69e-06
                           10        20
                   ....*....|....*....|..
gi 1343911068 4135 CENGGTCVNTPGSFYCNCTPGF 4156
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
4047-4082 1.19e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 1.19e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1343911068  4047 DPCL-HQPCHNGATCNSLPsGGFSCSCSHQFT-GGNCE 4082
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4088-4116 1.58e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 44.30  E-value: 1.58e-05
                           10        20
                   ....*....|....*....|....*....
gi 1343911068 4088 CVPNPCQNSGVCKPIGNAFLCSCRRGFRG 4116
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4048-4082 2.20e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 44.00  E-value: 2.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1343911068 4048 PC-LHQPCHNGATCNSLPsGGFSCSCSHQFTG-GNCE 4082
Cdd:cd00053      1 ECaASNPCSNGGTCVNTP-GSYRCVCPPGYTGdRSCE 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4088-4120 5.21e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 43.23  E-value: 5.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1343911068 4088 C-VPNPCQNSGVCKPIGNAFLCSCRRGFRG-LVCE 4120
Cdd:cd00053      2 CaASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4049-4078 1.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 1.70e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1343911068 4049 CLHQPCHNGATCNSLPsGGFSCSCSHQFTG 4078
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTG 29
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 410-474 1.86e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 42.72  E-value: 1.86e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   410 NVEYILMPSKDLDFFQINTFTGVISTTRWLTKVSNNLFNLEVV-----EISSDLRVKVLITIEDANDNTP 474
Cdd:smart00112   12 KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEatdggGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
54-156 1.12e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.13  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068   54 YHATIYENSAARTyanSKIKMGITlDKrflD------IRYRIVSGDEEGFFKAEEYvLGDfcflrIRTKggnsAILNREI 127
Cdd:pfam00028    1 YSASVPENAPVGT---EVLTVTAT-DP---DlgpngrIFYSILGGGPGGNFRIDPD-TGD-----ISTT----KPLDRES 63

                           90       100
                   ....*....|....*....|....*....
gi 1343911068  128 QSNYVLTVKAFVKGEVFLEAWTKVSVQVL 156
Cdd:pfam00028   64 IGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 293-368 1.18e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.80  E-value: 1.18e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1343911068   293 NVDDSDEGVNGEIdSVIIVDGDPLGQFFLEKTKEneyAIKATESINWESFPFgCNITLQAKDRGIPPKLSTFPVHI 368
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETG---EITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTATVTI 71
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2725-2823 1.82e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.79  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 2725 IPENTPIGSVIGTVRVSIPPEYSSLTATFATANGEsGENNREMVFLVEKDTGVIKLDKALDHEAIKEFYFKVTATVKQAK 2804
Cdd:cd00031      2 PDGSAVEGRSRGSFRVSIPTDLIASSGEIIKISAA-GKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGAN 80

                           90
                   ....*....|....*....
gi 1343911068 2805 LdSMTSANVKVNVFDINDN 2823
Cdd:cd00031     81 V-PQTSSVFSIEVYDENDN 98
EGF smart00181
Epidermal growth factor-like domain;
4090-4120 2.84e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 38.27  E-value: 2.84e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1343911068  4090 PNPCQNsGVCKPIGNAFLCSCRRGFRGLV-CE 4120
Cdd:smart00181    5 GGPCSN-GTCINTPGSYTCSCPPGYTGDKrCE 35
Cadherin pfam00028
Cadherin domain;
3574-3644 4.72e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 4.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1343911068 3574 IHVVTMEDEFPGGVIGQLHATDAD------PYDALTFGHAPqaqhGLFKISPHDGRIIALGGLDA---GSYSLNVTVSDG 3644
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlgpngrIFYSILGGGPG----GNFRIDPDTGDISTTKPLDResiGEYELTVEATDS 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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