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Conserved domains on  [gi|13436065|gb|AAH04859|]
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Proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [Homo sapiens]

Protein Classification

26S proteasome non-ATPase regulatory subunit( domain architecture ID 10476731)

26S proteasome non-ATPase regulatory subunit is a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rpn3_C pfam08375
Proteasome regulatory subunit C-terminal; This eukaryotic domain is found at the C-terminus of ...
 465-523 1.15e-24

Proteasome regulatory subunit C-terminal; This eukaryotic domain is found at the C-terminus of 26S proteasome regulatory subunits such as the non-ATPase Rpn3 subunit which is essential for proteasomal function. It occurs together with the PCI/PINT domain (pfam01399).


:

Pssm-ID: 462452  Cd Length: 57  Bit Score: 96.50  E-value: 1.15e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13436065   465 DIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAeeRREREQQDLEFAK 523
Cdd:pfam08375   1 DVYSTNEPQEAFHQRIKFCLQLHNESVKAMRYPPDAHKKELESA--EEAREREERELAK 57
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 358-462 9.84e-24

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


:

Pssm-ID: 460195  Cd Length: 105  Bit Score: 95.75  E-value: 9.84e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13436065   358 MPYFLLTQAVRTGNLAKFNQVLDQFGEK-FQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSpEDAEF 436
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEElLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSV-DEVEK 79

                          90       100
                  ....*....|....*....|....*.
gi 13436065   437 IVAKAIRDGVIEASINHEKGYVQSKE 462
Cdd:pfam01399  80 ILAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Name Accession Description Interval E-value
Rpn3_C pfam08375
Proteasome regulatory subunit C-terminal; This eukaryotic domain is found at the C-terminus of ...
 465-523 1.15e-24

Proteasome regulatory subunit C-terminal; This eukaryotic domain is found at the C-terminus of 26S proteasome regulatory subunits such as the non-ATPase Rpn3 subunit which is essential for proteasomal function. It occurs together with the PCI/PINT domain (pfam01399).


Pssm-ID: 462452  Cd Length: 57  Bit Score: 96.50  E-value: 1.15e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13436065   465 DIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAeeRREREQQDLEFAK 523
Cdd:pfam08375   1 DVYSTNEPQEAFHQRIKFCLQLHNESVKAMRYPPDAHKKELESA--EEAREREERELAK 57
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 358-462 9.84e-24

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 95.75  E-value: 9.84e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13436065   358 MPYFLLTQAVRTGNLAKFNQVLDQFGEK-FQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSpEDAEF 436
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEElLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSV-DEVEK 79

                          90       100
                  ....*....|....*....|....*.
gi 13436065   437 IVAKAIRDGVIEASINHEKGYVQSKE 462
Cdd:pfam01399  80 ILAKLIRDGRIRAKIDQVNGIVVFSK 105
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 393-483 1.21e-20

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 86.53  E-value: 1.21e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13436065    393 TLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEdAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYStrEP 472
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPE-VEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRS--EP 77

                           90
                   ....*....|.
gi 13436065    473 QLAFHQRISFC 483
Cdd:smart00088  78 LAQFAETLKKL 88
 
Name Accession Description Interval E-value
Rpn3_C pfam08375
Proteasome regulatory subunit C-terminal; This eukaryotic domain is found at the C-terminus of ...
 465-523 1.15e-24

Proteasome regulatory subunit C-terminal; This eukaryotic domain is found at the C-terminus of 26S proteasome regulatory subunits such as the non-ATPase Rpn3 subunit which is essential for proteasomal function. It occurs together with the PCI/PINT domain (pfam01399).


Pssm-ID: 462452  Cd Length: 57  Bit Score: 96.50  E-value: 1.15e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 13436065   465 DIYSTREPQLAFHQRISFCLDIHNMSVKAMRFPPKSYNKDLESAeeRREREQQDLEFAK 523
Cdd:pfam08375   1 DVYSTNEPQEAFHQRIKFCLQLHNESVKAMRYPPDAHKKELESA--EEAREREERELAK 57
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
 358-462 9.84e-24

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 95.75  E-value: 9.84e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13436065   358 MPYFLLTQAVRTGNLAKFNQVLDQFGEK-FQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSpEDAEF 436
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYKEElLLDDGLAEHLEDLRRKIREHNLRQLSKPYSSISLSDLAKLLGLSV-DEVEK 79

                          90       100
                  ....*....|....*....|....*.
gi 13436065   437 IVAKAIRDGVIEASINHEKGYVQSKE 462
Cdd:pfam01399  80 ILAKLIRDGRIRAKIDQVNGIVVFSK 105
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 393-483 1.21e-20

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 86.53  E-value: 1.21e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13436065    393 TLIIRLRHNVIKTGVRMISLSYSRISLADIAQKLQLDSPEdAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYStrEP 472
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVPE-VEKLVSKAIRDGEISAKIDQVNGIVEFEEVDPRRS--EP 77

                           90
                   ....*....|.
gi 13436065    473 QLAFHQRISFC 483
Cdd:smart00088  78 LAQFAETLKKL 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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