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Conserved domains on  [gi|134142307|gb|ABO61497|]
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beta tubulin, partial [Heterocapsa arctica]

Protein Classification

tubulin beta chain( domain architecture ID 11476486)

tubulin beta chain is part of tubulin, a dimer of alpha and beta chains, which is the major constituent of microtubules and binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN00220 PLN00220
tubulin beta chain; Provisional
1-368 0e+00

tubulin beta chain; Provisional


:

Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 815.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   1 LQLERINVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 80
Cdd:PLN00220  42 LQLERINVYYNEASGGRYVPRAVLMDLEPGTMDSVRSGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  81 KEAEGCDCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPSPKVSDTVVEPYNAVLSFHQLVENADECFL 160
Cdd:PLN00220 122 KEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMV 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 161 LDNEALYDICFRTLKLTTPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQQY 240
Cdd:PLN00220 202 LDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQY 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 241 RALTVPELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASVCDIPPKGL 320
Cdd:PLN00220 282 RALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPKGL 361
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 134142307 321 KMAVAFAGNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGMDEMEFT 368
Cdd:PLN00220 362 KMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFT 409
 
Name Accession Description Interval E-value
PLN00220 PLN00220
tubulin beta chain; Provisional
1-368 0e+00

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 815.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   1 LQLERINVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 80
Cdd:PLN00220  42 LQLERINVYYNEASGGRYVPRAVLMDLEPGTMDSVRSGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  81 KEAEGCDCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPSPKVSDTVVEPYNAVLSFHQLVENADECFL 160
Cdd:PLN00220 122 KEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMV 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 161 LDNEALYDICFRTLKLTTPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQQY 240
Cdd:PLN00220 202 LDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQY 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 241 RALTVPELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASVCDIPPKGL 320
Cdd:PLN00220 282 RALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPKGL 361
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 134142307 321 KMAVAFAGNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGMDEMEFT 368
Cdd:PLN00220 362 KMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFT 409
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
1-368 0e+00

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 759.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   1 LQLERINVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 80
Cdd:cd02187   41 LQLERINVYFNEASGGKYVPRAVLVDLEPGTIDSVRSGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  81 KEAEGCDCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPSPKVSDTVVEPYNAVLSFHQLVENADECFL 160
Cdd:cd02187  121 KEAESCDCLQGFQLTHSLGGGTGSGLGTLLLSKLREEYPDRIMSTFSVLPSPKVSDTVVEPYNAVLSLHQLVENADETFC 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 161 LDNEALYDICFRTLKLTTPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQQY 240
Cdd:cd02187  201 IDNEALYNICQRTLKLTQPTYDDLNHLISQVMSGITSSLRFPGQLNSDLRKLATNLVPFPRLHFLTPGFAPLTSRGSQQY 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 241 RALTVPELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASVCDIPPKGL 320
Cdd:cd02187  281 RKLTVPELTQQLFDAKNMMAACDPRHGRYLTAAAIFRGRISTKEVDEQMSKVQNKNSSYFVEWIPNNVKTSVCDIPPRGL 360
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 134142307 321 KMAVAFAGNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGMDEMEFT 368
Cdd:cd02187  361 KMSATFIGNSTAIQELFKRLSEQFTAMFRRKAFLHWYTGEGMDEMEFT 408
Tubulin smart00864
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ...
16-203 6.92e-61

Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


Pssm-ID: 214867 [Multi-domain]  Cd Length: 192  Bit Score: 194.24  E-value: 6.92e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307    16 GRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYT-----EGAELIDSVLDVVRKEAEGCDclq 90
Cdd:smart00864   8 GGGGPNAVNVDLEPGVIDGVRANTDAQALNPESLASGKIQAGNNWTRGLGAgadpeVGREAAEESLDEIREELEGAD--- 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307    91 GFQMTHSlgggtgagmgtL----------LISKVREEYPDRVMeTFSVIpsPKVSDTVVEPYNAVLSFHQLVENADECFL 160
Cdd:smart00864  85 GVFITAG-----------MgggtgtgaapVIAEIAKEYGILTV-AVVTK--PFSFEGVVRPYNAELGLEELREHVDSLIV 150
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 134142307   161 LDNEALYDICFRTLKLtTPTYGDLNHLVSAAISGVTCGLRFPG 203
Cdd:smart00864 151 IDNDALLDICGRKLPL-RPAFKDANDLLAQAVSGITDLIRFPG 192
Tubulin_C pfam03953
Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. ...
220-340 1.09e-57

Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).


Pssm-ID: 397858 [Multi-domain]  Cd Length: 125  Bit Score: 183.59  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  220 PRLHFFMTGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSY 299
Cdd:pfam03953   1 PRLHFLLTSYAPLTSANKASHEKTSVLDVTRRLFDPKNQMVSCDPRNGKYMACALLYRGDVSPKDVHRAIQRIKEKRSAQ 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 134142307  300 FVEWIPNNIKASVCDIPPKGLKM---AVAFAGNSTAIQEMFKRV 340
Cdd:pfam03953  81 FVEWCPTGIKVAICSQSPYVVPGskvSGLMLANTTSIAELFQRL 124
 
Name Accession Description Interval E-value
PLN00220 PLN00220
tubulin beta chain; Provisional
1-368 0e+00

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 815.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   1 LQLERINVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 80
Cdd:PLN00220  42 LQLERINVYYNEASGGRYVPRAVLMDLEPGTMDSVRSGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  81 KEAEGCDCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPSPKVSDTVVEPYNAVLSFHQLVENADECFL 160
Cdd:PLN00220 122 KEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMV 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 161 LDNEALYDICFRTLKLTTPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQQY 240
Cdd:PLN00220 202 LDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQY 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 241 RALTVPELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASVCDIPPKGL 320
Cdd:PLN00220 282 RALTVPELTQQMWDAKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPKGL 361
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 134142307 321 KMAVAFAGNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGMDEMEFT 368
Cdd:PLN00220 362 KMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFT 409
PTZ00010 PTZ00010
tubulin beta chain; Provisional
1-368 0e+00

tubulin beta chain; Provisional


Pssm-ID: 240228 [Multi-domain]  Cd Length: 445  Bit Score: 801.68  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   1 LQLERINVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 80
Cdd:PTZ00010  42 LQLERINVYYNEATGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  81 KEAEGCDCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPSPKVSDTVVEPYNAVLSFHQLVENADECFL 160
Cdd:PTZ00010 122 KEAESCDCLQGFQITHSLGGGTGSGMGTLLISKLREEYPDRIMMTFSVFPSPKVSDTVVEPYNATLSVHQLVENADESMC 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 161 LDNEALYDICFRTLKLTTPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQQY 240
Cdd:PTZ00010 202 IDNEALYDICFRTLKLTTPTYGDLNHLVSAVMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQY 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 241 RALTVPELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASVCDIPPKGL 320
Cdd:PTZ00010 282 RGLSVPELTQQMFDAKNMMCAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKSSVCDIPPKGL 361
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 134142307 321 KMAVAFAGNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGMDEMEFT 368
Cdd:PTZ00010 362 KMSVTFIGNSTAIQEMFRRVGEQFTAMFRRKAFLHWYTGEGMDEMEFT 409
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
1-368 0e+00

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 759.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   1 LQLERINVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 80
Cdd:cd02187   41 LQLERINVYFNEASGGKYVPRAVLVDLEPGTIDSVRSGPYGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVR 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  81 KEAEGCDCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPSPKVSDTVVEPYNAVLSFHQLVENADECFL 160
Cdd:cd02187  121 KEAESCDCLQGFQLTHSLGGGTGSGLGTLLLSKLREEYPDRIMSTFSVLPSPKVSDTVVEPYNAVLSLHQLVENADETFC 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 161 LDNEALYDICFRTLKLTTPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQQY 240
Cdd:cd02187  201 IDNEALYNICQRTLKLTQPTYDDLNHLISQVMSGITSSLRFPGQLNSDLRKLATNLVPFPRLHFLTPGFAPLTSRGSQQY 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 241 RALTVPELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASVCDIPPKGL 320
Cdd:cd02187  281 RKLTVPELTQQLFDAKNMMAACDPRHGRYLTAAAIFRGRISTKEVDEQMSKVQNKNSSYFVEWIPNNVKTSVCDIPPRGL 360
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 134142307 321 KMAVAFAGNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGMDEMEFT 368
Cdd:cd02187  361 KMSATFIGNSTAIQELFKRLSEQFTAMFRRKAFLHWYTGEGMDEMEFT 408
Tubulin cd06059
The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct ...
21-368 1.42e-148

The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology.


Pssm-ID: 276963 [Multi-domain]  Cd Length: 387  Bit Score: 424.69  E-value: 1.42e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  21 RAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGCDCLQGFQMTHSLGG 100
Cdd:cd06059   23 RAVLVDMEEGVINEVLKGPLGQLFDPNQFVTGVSGAGNNWAVGYYVYGPKYIESILDRIRKQVEKCDSLQGFFILHSLGG 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 101 GTGAGMGTLLISKVREEYPDRVMETFSVIPSPKVSDTVVEPYNAVLSFHQLVENADECFLLDNEALYDICFR---TLKLT 177
Cdd:cd06059  103 GTGSGLGSYLLELLEDEYPKVYRFTFSVFPSPDDDNVITSPYNSVLALNHLTEHADCVLPIDNEALYDICNRqpaTLDID 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 178 TPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQQYRALTVPELTQQMFDAKN 257
Cdd:cd06059  183 FPPFDDMNNLVAQLLSSLTSSLRFEGSLNVDLNEITTNLVPFPRLHFLLPSLSPLTSANDVTLEPLTLDQLFSDLFSKDN 262
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 258 MMCAADPRHGRYLTAAALFRGRMST-KEVDEQMLNVQNKNSsyFVEWIPNNIKASVCDIPPKGLKMAVAFAGNSTAIQEM 336
Cdd:cd06059  263 QLVGCDPRHGTYLACALLLRGKVFSlSDVRRNIDRIKPKLK--FISWNPDGFKVGLCSVPPVGQKYSLLFLSNNTSIAST 340
                        330       340       350
                 ....*....|....*....|....*....|..
gi 134142307 337 FKRVAEYFTAMFRRKAFLHWYTGEGMDEMEFT 368
Cdd:cd06059  341 FERLIERFDKLYKRKAFLHHYTGEGMEEGDFS 372
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
7-368 1.32e-146

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 421.56  E-value: 1.32e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   7 NVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGC 86
Cdd:cd02186   49 NTFFSETGSGKYVPRAVFVDLEPTVIDEIRTGPYRQLFHPEQLISGKEDAANNFARGYYTIGKEIIDPVLDRIRKLAEQC 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  87 DCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPSPKVSDTVVEPYNAVLSFHQLVENADECFLLDNEAL 166
Cdd:cd02186  129 DGLQGFLIFHSVGGGTGSGLTSLLLERLSVDYGKKSKLEFSIYPSPQVSTSVVEPYNSVLTTHSLLEHSDCSILLDNEAL 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 167 YDICFRTLKLTTPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQQYRALTVP 246
Cdd:cd02186  209 YDICRRQLDIERPTYTNLNRLIAQVVSSLTASLRFDGALNVDLNEFQTNLVPYPRIHFPLVSYAPIISAEKANHEQLSVQ 288
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 247 ELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASVCDIPP--------- 317
Cdd:cd02186  289 EITNSCFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPtvvpgsdla 368
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 134142307 318 KGLKMAVAFAgNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGMDEMEFT 368
Cdd:cd02186  369 KVDRSVCMLA-NSTAIAEAFQRLDHKFDLLYSKRAFVHWYVGEGMEEGEFS 418
PTZ00335 PTZ00335
tubulin alpha chain; Provisional
7-368 4.24e-129

tubulin alpha chain; Provisional


Pssm-ID: 185562 [Multi-domain]  Cd Length: 448  Bit Score: 377.51  E-value: 4.24e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   7 NVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGC 86
Cdd:PTZ00335  50 NTFFSETGAGKHVPRCVFLDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNC 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  87 DCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPSPKVSDTVVEPYNAVLSFHQLVENADECFLLDNEAL 166
Cdd:PTZ00335 130 TGLQGFLVFHAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVMLDNEAI 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 167 YDICFRTLKLTTPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQQYRALTVP 246
Cdd:PTZ00335 210 YDICRRNLDIERPTYTNLNRLIAQVISSLTASLRFDGALNVDLTEFQTNLVPYPRIHFMLSSYAPIISAEKAYHEQLSVA 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 247 ELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASV-----CDIPPKGL- 320
Cdd:PTZ00335 290 EITNSAFEPANMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGInyqppTVVPGGDLa 369
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 134142307 321 --KMAVAFAGNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGMDEMEFT 368
Cdd:PTZ00335 370 kvQRAVCMISNSTAIAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFS 419
Tubulin_FtsZ_Cetz-like cd00286
Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, ...
22-330 5.15e-122

Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, gamma-, delta-, epsilon, and zeta-tubulins as well as FtsZ and CetZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. A recent study found that CetZ proteins, formerly annotated FtsZ type 2, are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development.


Pssm-ID: 276954 [Multi-domain]  Cd Length: 332  Bit Score: 355.18  E-value: 5.15e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  22 AVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQS--GAGNNWAKGHYTEGAELIDSVLDVVRKEAEGCDCLQGFQMTHSLG 99
Cdd:cd00286   22 AVLVDLEPAVLDELLSGPLRQLFHPENIILIQKyhGAGNNWAKGHSVAGEEYQEEILDAIRKEVEECDELQGFFITHSLG 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 100 GGTGAGMGTLLISKVREEYPDRVMETFSVIPSPKVSdTVVEPYNAVLSFHQLVENADECFLLDNEALYDICFRTLKLTTP 179
Cdd:cd00286  102 GGTGSGLGPLLAERLKDEYPNRLVVTFSILPGPDEG-VIVYPYNAALTLKTLTEHADCLLLVDNEALYDICPRPLHIDAP 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 180 TYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM 259
Cdd:cd00286  181 AYDHINELVAQRLGSLTEALRFEGSLNVDLRELAENLVPLPRGHFLMLGYAPLDSATSATPRSLRVKELTRRAFLPANLL 260
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 134142307 260 CAADPRHGRYLTAAALFRGR--MSTKEVDEQMLNVQNKNSSYFvEWIPNNIKASVCDIPPKGLKMAVAFAGNS 330
Cdd:cd00286  261 VGCDPDHGEAIAALLVIRGPpdLSSKEVERAIARVKETLGHLF-SWSPAGVKTGISPKPPAEGEVSVLALLNS 332
PLN00221 PLN00221
tubulin alpha chain; Provisional
7-368 1.85e-120

tubulin alpha chain; Provisional


Pssm-ID: 177802  Cd Length: 450  Bit Score: 355.66  E-value: 1.85e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   7 NVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGC 86
Cdd:PLN00221  50 NTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNC 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  87 DCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPSPKVSDTVVEPYNAVLSFHQLVENADECFLLDNEAL 166
Cdd:PLN00221 130 TGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAI 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 167 YDICFRTLKLTTPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQQYRALTVP 246
Cdd:PLN00221 210 YDICRRSLDIERPTYTNLNRLISQVISSLTASLRFDGALNVDITEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVA 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 247 ELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASVCDIPPK-------- 318
Cdd:PLN00221 290 EITNSAFEPASMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPTvvpggdla 369
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 134142307 319 GLKMAVAFAGNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGMDEMEFT 368
Cdd:PLN00221 370 KVQRAVCMISNSTAVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFS 419
gamma_tubulin cd02188
The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of ...
4-367 3.11e-104

The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping.


Pssm-ID: 276957 [Multi-domain]  Cd Length: 430  Bit Score: 313.32  E-value: 3.11e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   4 ERINVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQ--SGAGNNWAKGhYTEGAELIDSVLDVVRK 81
Cdd:cd02188   44 DRKDVFFYQADDEHYIPRAILLDLEPRVINSIQNSPYKNLFNPENIYLSKegGGAGNNWASG-YSQGEKVQEEILDIIDR 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  82 EAEGCDCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPSPK-VSDTVVEPYNAVLSFHQLVENADECFL 160
Cdd:cd02188  123 EAEGSDSLEGFVLCHSIAGGTGSGMGSYLLERLSDRYPKKLIQTYSVFPNQEeSSDVVVQPYNSILTLKRLTLNADCVVV 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 161 LDNEALYDICFRTLKLTTPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTS-RGSQQ 239
Cdd:cd02188  203 LDNTALNRIATDRLKIDNPSFSQINSLISTVMSASTSTLRFPGYMNNDLVSLISSLIPTPRLHFLMTSYTPLTSdQVASS 282
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 240 YRALTVPELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASVCDIPPK- 318
Cdd:cd02188  283 VRKTTVLDVMRRLLQPKNRMVSTSTKNGCYISILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSKKSPYv 362
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 134142307 319 -------GLKMAvafagNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGMDE---MEF 367
Cdd:cd02188  363 qtahrvsGLMLA-----NHTSISSLFEKILSQYDKLRKRNAFLENYRKEDMFQdnlEEF 416
epsilon_tubulin cd02190
The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the ...
21-368 2.24e-86

The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not ubiquitous among eukaryotes play a role in basal body/centriole morphogenesis.


Pssm-ID: 276959 [Multi-domain]  Cd Length: 449  Bit Score: 268.34  E-value: 2.24e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  21 RAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGCDCLQGFQMTHSLGG 100
Cdd:cd02190   68 RAVLIDMEEGVVNELLKGPLGDLFDETQLVTDVSGAGNNWAHGYHEYGPQYGESILEKLRRAAEKCDSLQSFFLLHSLGG 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 101 GTGAGMGTLLISKVREEYPDRVMETFSVIPSpKVSDTVVEPYNAVLSFHQLVENADECFLLDNEALYDICFRTLKLTTPT 180
Cdd:cd02190  148 GTGSGLGSYILELLEDEFPDVYRFVTSVFPS-GDDDVITSPYNSVLALRELTEHADCVLPVENQALMDIVNKIKSSKDKG 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 181 ----------------------YGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLTSRGSQ 238
Cdd:cd02190  227 ktgvlaainssgggqkkgkkkpFDDMNNIVANLLLNLTSSMRFEGSLNVDLNEITTNLVPFPRLHFLLSSLSPLYALADV 306
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 239 QYRALTVPELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEqmlNVQN-KNSSYFVEWIPNNIKASVCDIPP 317
Cdd:cd02190  307 RLPPRRLDQMFSDAFSRDHQLLKADPKHGLYLACALLVRGNVSISDLRR---NIDRlKRQLKFVSWNQDGWKIGLCSVPP 383
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 134142307 318 KGLKMAVAFAGNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTgEGMDEMEFT 368
Cdd:cd02190  384 VGQPYSLLCLANNTCIKPTFTEMHERFDKLYKRKAHLHHYT-QYMEQDDFD 433
PLN00222 PLN00222
tubulin gamma chain; Provisional
4-362 5.74e-79

tubulin gamma chain; Provisional


Pssm-ID: 215108 [Multi-domain]  Cd Length: 454  Bit Score: 249.38  E-value: 5.74e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   4 ERINVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSG--AGNNWAKGhYTEGAELIDSVLDVVRK 81
Cdd:PLN00222  46 DRKDVFFYQADDEHYIPRALLIDLEPRVINGIQNSEYRNLYNHENIFVSDHGggAGNNWASG-YHQGEQVEEDIMDMIDR 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  82 EAEGCDCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPS-PKVSDTVVEPYNAVLSFHQLVENADECFL 160
Cdd:PLN00222 125 EADGSDSLEGFVLCHSIAGGTGSGMGSYLLEALNDRYSKKLVQTYSVFPNqMETSDVVVQPYNSLLTLKRLTLNADCVVV 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 161 LDNEALYDICFRTLKLTTPTYGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPL-TSRGSQQ 239
Cdd:PLN00222 205 LDNTALNRIAVDRLHLENPTFAQTNSLVSTVMSASTTTLRYPGYMNNDLVGLLASLIPTPRCHFLMTGYTPLtVERQANV 284
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 240 YRALTVPELTQQMFDAKNMMCAADPR-----HGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSYFVEWIPNNIKASVCD 314
Cdd:PLN00222 285 IRKTTVLDVMRRLLQTKNIMVSSYARtkeasQAKYISILNIIQGEVDPTQVHKSLQRIRERKLANFIEWGPASIQVALSR 364
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 134142307 315 IPP--------KGLKMAvafagNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGM 362
Cdd:PLN00222 365 KSPyvqtahrvSGLMLA-----NHTSIRHLFSKCLSQYDKLRKKQAFLDNYRKFPM 415
PTZ00387 PTZ00387
epsilon tubulin; Provisional
21-368 1.40e-77

epsilon tubulin; Provisional


Pssm-ID: 240395 [Multi-domain]  Cd Length: 465  Bit Score: 246.17  E-value: 1.40e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  21 RAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGCDCLQGFQMTHSLGG 100
Cdd:PTZ00387  63 RAVLVDMEEGVLNQILKSPLGDLFDENFFVSDVSGAGNNWAVGHMEYGDKYIDSISESVRRQVEQCDSLQSFFLMHSLGG 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 101 GTGAGMGTLLISKVREEYPDRVMETFSVIPSpKVSDTVVEPYNAVLSFHQLVENADECFLLDNEALYDICFRTLKL---- 176
Cdd:PTZ00387 143 GTGSGLGTRILGMLEDEFPHVFRFCPVVFPS-AVDDVITSPYNSFFALRELIEHADCVLPLDNDALANIADSALSRkkkk 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 177 -----------------TTPT------YGDLNHLVSAAISGVTCGLRFPGQLNCDLRKIAVNLIPFPRLHFFMTGFAPLT 233
Cdd:PTZ00387 222 lakgnikrgpqphkysvAKPTetkklpYDKMNNIVAQLLSNLTSSMRFEGSLNVDINEITTNLVPYPRLHFLTSSIAPLV 301
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 234 SRGSQQYRALTVPELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVqnKNSSYFVEWIPNNIKASVC 313
Cdd:PTZ00387 302 SLKDVAVGPRRLDQMFKDCLDPDHQMVAATPEAGKYLATALIVRGPQNVSDVTRNILRL--KEQLNMIYWNEDGFKTGLC 379
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 134142307 314 DIPPKGLKMAVAFAGNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTgEGMDEMEFT 368
Cdd:PTZ00387 380 NVSPLGQPYSLLCLANNCCIRNKFESMLERFNKLYKRKSHVHHYT-EYLEQAYFD 433
Tubulin smart00864
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ...
16-203 6.92e-61

Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


Pssm-ID: 214867 [Multi-domain]  Cd Length: 192  Bit Score: 194.24  E-value: 6.92e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307    16 GRYVPRAVLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYT-----EGAELIDSVLDVVRKEAEGCDclq 90
Cdd:smart00864   8 GGGGPNAVNVDLEPGVIDGVRANTDAQALNPESLASGKIQAGNNWTRGLGAgadpeVGREAAEESLDEIREELEGAD--- 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307    91 GFQMTHSlgggtgagmgtL----------LISKVREEYPDRVMeTFSVIpsPKVSDTVVEPYNAVLSFHQLVENADECFL 160
Cdd:smart00864  85 GVFITAG-----------MgggtgtgaapVIAEIAKEYGILTV-AVVTK--PFSFEGVVRPYNAELGLEELREHVDSLIV 150
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 134142307   161 LDNEALYDICFRTLKLtTPTYGDLNHLVSAAISGVTCGLRFPG 203
Cdd:smart00864 151 IDNDALLDICGRKLPL-RPAFKDANDLLAQAVSGITDLIRFPG 192
Tubulin_C pfam03953
Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. ...
220-340 1.09e-57

Tubulin C-terminal domain; This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).


Pssm-ID: 397858 [Multi-domain]  Cd Length: 125  Bit Score: 183.59  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  220 PRLHFFMTGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMCAADPRHGRYLTAAALFRGRMSTKEVDEQMLNVQNKNSSY 299
Cdd:pfam03953   1 PRLHFLLTSYAPLTSANKASHEKTSVLDVTRRLFDPKNQMVSCDPRNGKYMACALLYRGDVSPKDVHRAIQRIKEKRSAQ 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 134142307  300 FVEWIPNNIKASVCDIPPKGLKM---AVAFAGNSTAIQEMFKRV 340
Cdd:pfam03953  81 FVEWCPTGIKVAICSQSPYVVPGskvSGLMLANTTSIAELFQRL 124
delta_zeta_tubulin-like cd02189
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ...
10-367 1.04e-56

The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.


Pssm-ID: 276958 [Multi-domain]  Cd Length: 433  Bit Score: 190.94  E-value: 1.04e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  10 FNEATGGRYVPRAVLMDLEPGTMDSVRAGPFGQL--FRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGCD 87
Cdd:cd02189   43 FSPFSDGKLKARCVLVDMEPKVVQQVLSRARSGAwsYDPKNVVCGQSGSGNNWALGYYVHGPSLLEDILEALRREAERCD 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307  88 CLQGFQMTHSLgggtgagmgtLLISKVREEYPdrvmETF---SVIPSPKVSDTVVEPYNAVLSFHQLVENADECFLLDNE 164
Cdd:cd02189  123 RLSGFLVLHSLaggtgsglgsRVTELLRDEYP----KAYllnTVVWPYSSGEVPVQNYNTLLTLSHLQESSDGILLFEND 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 165 ALYDICFRTLKLTTP-TYGDLNHLVSAAISGV---TCGLRFPGQLN-CDLRKIAVNLIPFPRLHFFmTGF-APLTSRGSQ 238
Cdd:cd02189  199 DLHKICSKLLGLKNPvSFSDINRVIARQLAGVllpSSSPTSPSPLRrCPLGDLLEHLCPHPAYKLL-TLRsLPQMPEPSR 277
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307 239 QYRALTVPEL---TQQMF----------DAKNMMCAADPRHGRYLTAAALFRG--RMSTKEVDEQMLnvqnKNSSYFVEW 303
Cdd:cd02189  278 AFSTYTWPSLlkrLRQMLitgakleegiDWQLLDTSGSHNPNKSLAALLVLRGkdAMKVHSADLSAF----KDPVLYSPW 353
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 134142307 304 IPNNIKASVCDIPPKGLKMAVAFAGNSTAIQEMFKRVAEYFTAMFRRKAFLHWYTGEGMDEMEF 367
Cdd:cd02189  354 VPNPFNVSVSPRPFNGYEKSVTLLSNSQNIVGPLDSLLEKAWQMFKAGAYLHQYEKYGVEEEDF 417
Tubulin pfam00091
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ...
2-170 4.39e-52

Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.


Pssm-ID: 459669 [Multi-domain]  Cd Length: 190  Bit Score: 171.25  E-value: 4.39e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307    2 QLERINVHFNEATGGRYVPRAVLMDLEPGTMDSVRAGpfgqlFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRK 81
Cdd:pfam00091  27 GIDSLNVFFSESGSVEFIPRSLAIDTDPQALNEIKAG-----FNPNKILLGKEGTGGNGAGGYPEIGREAAEESLEEIRK 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   82 EAEGCDCLQGFQMTHSLGGGTGAGMGTLLISKVREEYPDRVMETFSVIPSpKVSDTVVEPYNAVLSFHQLVENADECFLL 161
Cdd:pfam00091 102 EVEGCDMLQGFFITASLGGGTGSGAAPVIAEILKELYPGALTVAVVTFPF-GFSEGVVRPYNAILGLKELIEHSDSVIVI 180

                  ....*....
gi 134142307  162 DNEALYDIC 170
Cdd:pfam00091 181 DNDALYDIC 189
Tubulin_C smart00865
Tubulin/FtsZ family, C-terminal domain; This domain is found in the tubulin alpha, beta and ...
205-342 8.08e-26

Tubulin/FtsZ family, C-terminal domain; This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea. This is the C-terminal domain.


Pssm-ID: 214868 [Multi-domain]  Cd Length: 120  Bit Score: 100.32  E-value: 8.08e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134142307   205 LNCDLRKIAVNLIPFPrlhFFMTGFAPLTSrgsqQYRALTVPELTQ--QMFDAKNMMCAADPRHgrYLTAAAlfrgRMST 282
Cdd:smart00865   1 INVDFADVKTVMVPMG---FAMMGIGPASG----ENRALEAAELAIssPLLEDSNIMGAKGVLV--NITGGP----DLTL 67
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134142307   283 KEVDEQMLNVQNKNSS-YFVEWIPNNikasVCDIPPKGLKMAVafagNSTAIQEMFKRVAE 342
Cdd:smart00865  68 KEVNEAMERIREKADPdAFIIWGPVI----DEELGGDEIRVTV----IATGIGSLFKRLSE 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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