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Conserved domains on  [gi|134032030|ref|NP_067423|]
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elongator complex protein 2 isoform 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11525814)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-415 4.97e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 4.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030  54 LNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKsvRLQGHEGPVCAVHAIYQSGpsegeqhaLIAS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAASADGT--------YLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 133 AASDSTVRIWSKKGSEVkyLQTLSFRDGFVLsvCLAILPgtNVPVLACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRG 212
Cdd:cd00200   69 GSSDKTIRLWDLETGEC--VRTLTGHTSYVS--SVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 213 VEWATFGRdlFLASCSQDCLIRIWRLymkpasfetKDGSLRlkentftikdggvrttvavtleTVLAGHENWVNAVHWQP 292
Cdd:cd00200  141 VAFSPDGT--FVASSSQDGTIKLWDL---------RTGKCV----------------------ATLTGHTGEVNSVAFSP 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 293 sfykDGVlqqpvRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTV 372
Cdd:cd00200  188 ----DGE-----KLLSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 134032030 373 NPRQwapeiVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLFA 415
Cdd:cd00200  252 ECVQ-----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
266-696 4.29e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 4.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 266 VRTTVAVTLETVLAGHENWVNAVHWQPSfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYD 345
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 346 CQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLfapWKKKDQKdr 425
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLATGK-- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 426 sqvtwhEIARPQIHGYNIKCLAMI-DRFQFVSGADEKVLRVFSAPRNFVenfsvisRQSLSHmlcddqdlpEGATVPALG 504
Cdd:COG2319  196 ------LLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKL-------LRTLTG---------HSGSVRSVA 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 505 LSNkalfQGDIAsqpfeedelispAFGSpqvtfqpavlnepptEDHLLQntLW-----PEIQKLYGHGYEIVCVACNNSK 579
Cdd:COG2319  254 FSP----DGRLL------------ASGS---------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDG 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 580 TLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWKRQDATssefdpffSLFA 659
Cdd:COG2319  301 KLLASGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--------LLRT 367

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 134032030 660 FTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:COG2319  368 LTG-----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
588-831 5.44e-10

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 5.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 588 ASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqDATSSEFDPFFSLfaftnkitsv 667
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksSHNPMEHPirpcssildvgSSVTAVSVcpvlNPAQRYIVAiG 743
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKL--LRTLTGHS-----------GAVTSVAF----SPDGKLLAS-G 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 744 LESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddddddddteqSEEGpEWLhfASCGEDHTVKI 823
Cdd:COG2319  181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF-----------------SPDG-KLL--ASGSADGTVRL 230


                 ....*...
gi 134032030 824 YRVNRRAL 831
Cdd:COG2319  231 WDLATGKL 238
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-415 4.97e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 4.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030  54 LNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKsvRLQGHEGPVCAVHAIYQSGpsegeqhaLIAS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAASADGT--------YLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 133 AASDSTVRIWSKKGSEVkyLQTLSFRDGFVLsvCLAILPgtNVPVLACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRG 212
Cdd:cd00200   69 GSSDKTIRLWDLETGEC--VRTLTGHTSYVS--SVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 213 VEWATFGRdlFLASCSQDCLIRIWRLymkpasfetKDGSLRlkentftikdggvrttvavtleTVLAGHENWVNAVHWQP 292
Cdd:cd00200  141 VAFSPDGT--FVASSSQDGTIKLWDL---------RTGKCV----------------------ATLTGHTGEVNSVAFSP 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 293 sfykDGVlqqpvRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTV 372
Cdd:cd00200  188 ----DGE-----KLLSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 134032030 373 NPRQwapeiVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLFA 415
Cdd:cd00200  252 ECVQ-----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
21-413 1.18e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 1.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030  21 ALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLK 99
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPDGKtLASGSADGTVRLWDLATGKLLR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 100 SvrLQGHEGPVCAVhAIyqSGPSEgeqhaLIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILP-GTnvpVL 178
Cdd:COG2319  157 T--LTGHSGAVTSV-AF--SPDGK-----LLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSV--AFSPdGK---LL 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 179 ACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetkdgslrlkent 258
Cdd:COG2319  220 ASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGR--LLASGSADGTVRLWDL-------------------- 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 259 ftikDGGvrttvavTLETVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWAPDEESgvwleqvRVGEVGG 338
Cdd:COG2319  276 ----ATG-------ELLRTLTGHSGGVNSVAFSP----DGK-----LLASGSDDGTVRLWDLATGK-------LLRTLTG 328

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134032030 339 NTLGFYDCQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRL 413
Cdd:COG2319  329 HTGAVRSVAFSPDGKTLASGSDDGTVRLW-----DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
266-696 4.29e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 4.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 266 VRTTVAVTLETVLAGHENWVNAVHWQPSfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYD 345
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 346 CQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLfapWKKKDQKdr 425
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLATGK-- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 426 sqvtwhEIARPQIHGYNIKCLAMI-DRFQFVSGADEKVLRVFSAPRNFVenfsvisRQSLSHmlcddqdlpEGATVPALG 504
Cdd:COG2319  196 ------LLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKL-------LRTLTG---------HSGSVRSVA 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 505 LSNkalfQGDIAsqpfeedelispAFGSpqvtfqpavlnepptEDHLLQntLW-----PEIQKLYGHGYEIVCVACNNSK 579
Cdd:COG2319  254 FSP----DGRLL------------ASGS---------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDG 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 580 TLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWKRQDATssefdpffSLFA 659
Cdd:COG2319  301 KLLASGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--------LLRT 367

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 134032030 660 FTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:COG2319  368 LTG-----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 559-825 3.66e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 3.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 559 EIQKLYGHGYEIVCVACNNSKTLLASAckasqKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 638
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 639 SLWkrqDATSSEFDPFFSLfaftnkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSSHNPMEHPirpcs 714
Cdd:cd00200  160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWdlstGKCLGTLRGHENG----- 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 715 sildvgssVTAVSVCPvlnpaQRYIVAIGLESGKICIYswnktnqeinDWTSCVETNPSQSHSLGIRRLCWkscsddddd 794
Cdd:cd00200  222 --------VNSVAFSP-----DGYLLASGSEDGTIRVW----------DLRTGECVQTLSGHTNSVTSLAW--------- 269

                        250       260       270
                 ....*....|....*....|....*....|.
gi 134032030 795 dddddteqSEEGPewlHFASCGEDHTVKIYR 825
Cdd:cd00200  270 --------SPDGK---RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
588-831 5.44e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 5.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 588 ASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqDATSSEFDPFFSLfaftnkitsv 667
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksSHNPMEHPirpcssildvgSSVTAVSVcpvlNPAQRYIVAiG 743
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKL--LRTLTGHS-----------GAVTSVAF----SPDGKLLAS-G 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 744 LESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddddddddteqSEEGpEWLhfASCGEDHTVKI 823
Cdd:COG2319  181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF-----------------SPDG-KLL--ASGSADGTVRL 230


                 ....*...
gi 134032030 824 YRVNRRAL 831
Cdd:COG2319  231 WDLATGKL 238
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 668-696 1.23e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.23e-05
                           10        20
                   ....*....|....*....|....*....
gi 134032030   668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
668-696 1.94e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.94e-05
                          10        20
                  ....*....|....*....|....*....
gi 134032030  668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
202-236 1.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 134032030  202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 202-236 1.81e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.81e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 134032030   202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-415 4.97e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 143.63  E-value: 4.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030  54 LNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKsvRLQGHEGPVCAVHAIYQSGpsegeqhaLIAS 132
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAASADGT--------YLAS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 133 AASDSTVRIWSKKGSEVkyLQTLSFRDGFVLsvCLAILPgtNVPVLACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRG 212
Cdd:cd00200   69 GSSDKTIRLWDLETGEC--VRTLTGHTSYVS--SVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 213 VEWATFGRdlFLASCSQDCLIRIWRLymkpasfetKDGSLRlkentftikdggvrttvavtleTVLAGHENWVNAVHWQP 292
Cdd:cd00200  141 VAFSPDGT--FVASSSQDGTIKLWDL---------RTGKCV----------------------ATLTGHTGEVNSVAFSP 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 293 sfykDGVlqqpvRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTV 372
Cdd:cd00200  188 ----DGE-----KLLSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 134032030 373 NPRQwapeiVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLFA 415
Cdd:cd00200  252 ECVQ-----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
21-413 1.18e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 1.18e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030  21 ALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLK 99
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPDGKtLASGSADGTVRLWDLATGKLLR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 100 SvrLQGHEGPVCAVhAIyqSGPSEgeqhaLIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILP-GTnvpVL 178
Cdd:COG2319  157 T--LTGHSGAVTSV-AF--SPDGK-----LLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSV--AFSPdGK---LL 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 179 ACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetkdgslrlkent 258
Cdd:COG2319  220 ASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGR--LLASGSADGTVRLWDL-------------------- 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 259 ftikDGGvrttvavTLETVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWAPDEESgvwleqvRVGEVGG 338
Cdd:COG2319  276 ----ATG-------ELLRTLTGHSGGVNSVAFSP----DGK-----LLASGSDDGTVRLWDLATGK-------LLRTLTG 328

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134032030 339 NTLGFYDCQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRL 413
Cdd:COG2319  329 HTGAVRSVAFSPDGKTLASGSDDGTVRLW-----DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-319 4.01e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.12  E-value: 4.01e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030  42 LYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNELVSGGS-DNRVIHWELENNQVLKSvrLQGHEGPVCAVhAIYQSG 120
Cdd:cd00200   77 LWDLETGECVRTLTGHTSYVSSVAF------SPDGRILSSSSrDKTIKVWDVETGKCLTT--LRGHTDWVNSV-AFSPDG 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 121 PsegeqhaLIASAASDSTVRIWSKKGSevKYLQTLSFRDGFVLSVCLAilpGTNVPVLACGDDDCrIHLYIQQDDQFQKa 200
Cdd:cd00200  148 T-------FVASSSQDGTIKLWDLRTG--KCVATLTGHTGEVNSVAFS---PDGEKLLSSSSDGT-IKLWDLSTGKCLG- 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 201 lSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLYMKpasfetkdgslrlkentftikdggvrttvavTLETVLAG 280
Cdd:cd00200  214 -TLRGHENGVNSVAFSPDGY--LLASGSEDGTIRVWDLRTG-------------------------------ECVQTLSG 259

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 134032030 281 HENWVNAVHWQPSfykdgvlqqPVRLLSASMDKTMILWA 319
Cdd:cd00200  260 HTNSVTSLAWSPD---------GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
266-696 4.29e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 4.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 266 VRTTVAVTLETVLAGHENWVNAVHWQPSfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYD 345
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 346 CQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLfapWKKKDQKdr 425
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLATGK-- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 426 sqvtwhEIARPQIHGYNIKCLAMI-DRFQFVSGADEKVLRVFSAPRNFVenfsvisRQSLSHmlcddqdlpEGATVPALG 504
Cdd:COG2319  196 ------LLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKL-------LRTLTG---------HSGSVRSVA 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 505 LSNkalfQGDIAsqpfeedelispAFGSpqvtfqpavlnepptEDHLLQntLW-----PEIQKLYGHGYEIVCVACNNSK 579
Cdd:COG2319  254 FSP----DGRLL------------ASGS---------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDG 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 580 TLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWKRQDATssefdpffSLFA 659
Cdd:COG2319  301 KLLASGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--------LLRT 367

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 134032030 660 FTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:COG2319  368 LTG-----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-237 2.39e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030  28 PGGLLAFGTS--CSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNELVSGGSDNRVIH-WELENNQVLKsvRLQ 104
Cdd:cd00200  103 PDGRILSSSSrdKTIKVWDVETGKCLTTLRGHTDWVNSVAF------SPDGTFVASSSQDGTIKlWDLRTGKCVA--TLT 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 105 GHEGPVCAVhAIYQSGPSegeqhalIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILPGTNvpVLACGDDD 184
Cdd:cd00200  175 GHTGEVNSV-AFSPDGEK-------LLSSSSDGTIKLWDLSTGKC--LGTLRGHENGVNSV--AFSPDGY--LLASGSED 240

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 134032030 185 CRIHLYiqQDDQFQKALSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWR 237
Cdd:cd00200  241 GTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGK--RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
73-468 1.12e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 1.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030  73 SPSNELVSGGSDNRVIHWELENNQVLKsvRLQGHEGPVCAVHAIYQSGpsegeqhaLIASAASDSTVRIWSKKGSEVkyL 152
Cdd:COG2319   46 PDGARLAAGAGDLTLLLLDAAAGALLA--TLLGHTAAVLSVAFSPDGR--------LLASASADGTVRLWDLATGLL--L 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 153 QTLSFRDGFVLSVclAILP-GTnvpVLACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDC 231
Cdd:COG2319  114 RTLTGHTGAVRSV--AFSPdGK---TLASGSADGTVRLWDLATGKLLRTLT--GHSGAVTSVAFSPDGK--LLASGSDDG 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 232 LIRIWRLymkpasfetkdgslrlkentftiKDGGVRTTvavtletvLAGHENWVNAVHWQPsfykDGvlQqpvRLLSASM 311
Cdd:COG2319  185 TVRLWDL-----------------------ATGKLLRT--------LTGHTGAVRSVAFSP----DG--K---LLASGSA 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 312 DKTMILWapDEESGvwleqVRVGEVGGNTLGFYDCQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQ 391
Cdd:COG2319  225 DGTVRLW--DLATG-----KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW-----DLATGELLRTLTGHSGGVN 292

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 134032030 392 DLMWDPEGEFIITTSTDQTTRLFapwkkkdqkDRSqvTWHEIARPQIHGYNIKCLAMI-DRFQFVSGADEKVLRVFSA 468
Cdd:COG2319  293 SVAFSPDGKLLASGSDDGTVRLW---------DLA--TGKLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
29-238 4.55e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 4.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030  29 GGLLAFGTS-CSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKsvRLQGH 106
Cdd:COG2319  216 GKLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAF------SPDGRlLASGSADGTVRLWDLATGELLR--TLTGH 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 107 EGPVCAVhAIYQSGpsegeqhALIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILPGTNVpvLACGDDDCR 186
Cdd:COG2319  288 SGGVNSV-AFSPDG-------KLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSV--AFSPDGKT--LASGSDDGT 353

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 134032030 187 IHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRL 238
Cdd:COG2319  354 VRLWDLATGELLRTLT--GHTGAVTSVAFSPDGR--TLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
21-645 1.92e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 1.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030  21 ALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWIrtedgSPSNELVSGGSDNRVIHWELENNQVLks 100
Cdd:COG2319   41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-----PDGRLLASASADGTVRLWDLATGLLL-- 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 101 VRLQGHEGPVCAVhAIYQSGpsegeqhALIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILP-GTnvpVLA 179
Cdd:COG2319  114 RTLTGHTGAVRSV-AFSPDG-------KTLASGSADGTVRLWDLATGKL--LRTLTGHSGAVTSV--AFSPdGK---LLA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 180 CGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetkdgslrlkentf 259
Cdd:COG2319  179 SGSDDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPDGK--LLASGSADGTVRLWDL--------------------- 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 260 tikDGGvrttvavTLETVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWapdeesgvwleqvrvgevggn 339
Cdd:COG2319  234 ---ATG-------KLLRTLTGHSGSVRSVAFSP----DGR-----LLASGSADGTVRLW--------------------- 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 340 tlgfydcqfgengtmiiahafhgalhlwkqstvNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLFapwkk 419
Cdd:COG2319  274 ---------------------------------DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW----- 315

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 420 kdqkdrsqvtwheiarpqihgynikclamidrfqfvsgadekvlrvfsaprnfvenfsvisrqslshmlcddqDLPEGAt 499
Cdd:COG2319  316 -------------------------------------------------------------------------DLATGK- 321

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 500 vpalglsnkalfqgdiasqpfeedelispafgspqvtfqpavlnepptedhllqntlwpEIQKLYGHGYEIVCVACNNSK 579
Cdd:COG2319  322 -----------------------------------------------------------LLRTLTGHTGAVRSVAFSPDG 342

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134032030 580 TLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWKRQD 645
Cdd:COG2319  343 KTLASGS-----DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
556-827 1.33e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 1.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 556 LW-----PEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLL 630
Cdd:COG2319  188 LWdlatgKLLRTLTGHTGAVRSVAFSPDGKLLASGS-----ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 631 AVSRDRTWSLWkrqDATSSEFDPFFslfaftnkitSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSSHNPM 706
Cdd:COG2319  263 SGSADGTVRLW---DLATGELLRTL----------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWdlatGKLLRTLTGH 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 707 EHPIRpcssildvgsSVtAVSvcpvlnPAQRYIVAiGLESGKICIysWNKTNQEindwtscvETNPSQSHSLGIRRLCWk 786
Cdd:COG2319  330 TGAVR----------SV-AFS------PDGKTLAS-GSDDGTVRL--WDLATGE--------LLRTLTGHTGAVTSVAF- 380

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 134032030 787 scsddddddddddteqSEEGPewlHFASCGEDHTVKIYRVN 827
Cdd:COG2319  381 ----------------SPDGR---TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
556-831 2.85e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 2.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 556 LW-----PEIQKLYGHGYEIVCVACNNSKTLLASACKASQkehaaIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLL 630
Cdd:COG2319  146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 631 AVSRDRTWSLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSShnpM 706
Cdd:COG2319  221 SGSADGTVRLW---DLATGKL-----LRTLTG-----HSGSVRSVAFSPDGRLLASGSADGTVRLWdlatGELLRT---L 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 707 EHPirpcssildvGSSVTAVSVCPvlnpaQRYIVAIGLESGKICIYSWnKTNQEINDWTScvetnpsqsHSLGIRRLCWk 786
Cdd:COG2319  285 TGH----------SGGVNSVAFSP-----DGKLLASGSDDGTVRLWDL-ATGKLLRTLTG---------HTGAVRSVAF- 338

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 134032030 787 scsddddddddddteqSEEGpEWLhfASCGEDHTVKIYRVNRRAL 831
Cdd:COG2319  339 ----------------SPDG-KTL--ASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 559-825 3.66e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 3.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 559 EIQKLYGHGYEIVCVACNNSKTLLASAckasqKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 638
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 639 SLWkrqDATSSEFDPFFSLfaftnkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSSHNPMEHPirpcs 714
Cdd:cd00200  160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWdlstGKCLGTLRGHENG----- 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 715 sildvgssVTAVSVCPvlnpaQRYIVAIGLESGKICIYswnktnqeinDWTSCVETNPSQSHSLGIRRLCWkscsddddd 794
Cdd:cd00200  222 --------VNSVAFSP-----DGYLLASGSEDGTIRVW----------DLRTGECVQTLSGHTNSVTSLAW--------- 269

                        250       260       270
                 ....*....|....*....|....*....|.
gi 134032030 795 dddddteqSEEGPewlHFASCGEDHTVKIYR 825
Cdd:cd00200  270 --------SPDGK---RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
559-831 3.87e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 3.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 559 EIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 638
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGS-----ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 639 SLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSshnPMEHPirpcs 714
Cdd:COG2319  187 RLW---DLATGKL-----LRTLTG-----HTGAVRSVAFSPDGKLLASGSADGTVRLWdlatGKLLR---TLTGH----- 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 715 sildvGSSVTAVSVCPvlnpaQRYIVAIGLESGKICIYSWNkTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddd 794
Cdd:COG2319  246 -----SGSVRSVAFSP-----DGRLLASGSADGTVRLWDLA-TGELLRTLT---------GHSGGVNSVAF--------- 296

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 134032030 795 dddddteqSEEGpEWLhfASCGEDHTVKIYRVNRRAL 831
Cdd:COG2319  297 --------SPDG-KLL--ASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 274-696 2.35e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 2.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 274 LETVLAGHENWVNAVHWQPsfykdgvlqQPVRLLSASMDKTMILWapDEESGvwlEQVRVGEvgGNTLGFYDCQFGENGT 353
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP---------DGKLLATGSGDGTIKVW--DLETG---ELLRTLK--GHTGPVRDVAASADGT 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 354 MIIAHAFHGALHLWKQSTVNPRQwapeiVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLfapwkkkdqkdrsqvtWHEI 433
Cdd:cd00200   65 YLASGSSDKTIRLWDLETGECVR-----TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKV----------------WDVE 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 434 ARPQI-----HGYNIKCLAMIDRFQFVSGA-DEKVLRVFsaprnfvenfsvisrqslshmlcddqdlpegatvpalglsn 507
Cdd:cd00200  124 TGKCLttlrgHTDWVNSVAFSPDGTFVASSsQDGTIKLW----------------------------------------- 162

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 508 kalfqgDIASqpfeedelispafgspqvtfqpavlnepptedhllqntlWPEIQKLYGHGYEIVCVACNNSKTLLASACK 587
Cdd:cd00200  163 ------DLRT---------------------------------------GKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 588 ASQkehaaIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRT---WSLWKRQdatssefdpffslfafTNKI 664
Cdd:cd00200  198 DGT-----IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTirvWDLRTGE----------------CVQT 256

                        410       420       430
                 ....*....|....*....|....*....|..
gi 134032030 665 TSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:cd00200  257 LSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 559-824 9.85e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.53  E-value: 9.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 559 EIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 638
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGS-----GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 639 SLWKRQdatssefdpffslfafTNKITSV---HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksshnpmehpir 711
Cdd:cd00200   76 RLWDLE----------------TGECVRTltgHTSYVSSVAFSPDGRILSSSSRDKTIKVWdvetGKC------------ 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 712 pCSSILDVGSSVTAVSVcpvlNPAQRYIVAIGLESgkiCIYSWNKTNQeindwtSCVETNPsqSHSLGIRRLCWKscsdd 791
Cdd:cd00200  128 -LTTLRGHTDWVNSVAF----SPDGTFVASSSQDG---TIKLWDLRTG------KCVATLT--GHTGEVNSVAFS----- 186

                        250       260       270
                 ....*....|....*....|....*....|...
gi 134032030 792 ddddddddteqseegPEWLHFASCGEDHTVKIY 824
Cdd:cd00200  187 ---------------PDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
551-831 1.09e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 1.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 551 LLQNTLWPEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLL 630
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-----ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 631 AVSRDRTWSLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksshnpm 706
Cdd:COG2319  137 SGSADGTVRLW---DLATGKL-----LRTLTG-----HSGAVTSVAFSPDGKLLASGSDDGTVRLWdlatGKL------- 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 707 ehpIRpcsSILDVGSSVTAVSVcpvlNPAQRYIvAIGLESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWk 786
Cdd:COG2319  197 ---LR---TLTGHTGAVRSVAF----SPDGKLL-ASGSADGTVRLWDL-ATGKLLRTLT---------GHSGSVRSVAF- 254

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 134032030 787 scsddddddddddteqSEEGPewlHFASCGEDHTVKIYRVNRRAL 831
Cdd:COG2319  255 ----------------SPDGR---LLASGSADGTVRLWDLATGEL 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 21-143 5.61e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 5.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030  21 ALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNELVSGGSDNRVIH-WELENNQVLK 99
Cdd:cd00200  182 SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF------SPDGYLLASGSEDGTIRvWDLRTGECVQ 255

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 134032030 100 SvrLQGHEGPVCAVhAIYQSGPsegeqhaLIASAASDSTVRIWS 143
Cdd:cd00200  256 T--LSGHTNSVTSL-AWSPDGK-------RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
588-831 5.44e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 5.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 588 ASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqDATSSEFDPFFSLfaftnkitsv 667
Cdd:COG2319   52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksSHNPMEHPirpcssildvgSSVTAVSVcpvlNPAQRYIVAiG 743
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKL--LRTLTGHS-----------GAVTSVAF----SPDGKLLAS-G 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 744 LESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddddddddteqSEEGpEWLhfASCGEDHTVKI 823
Cdd:COG2319  181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF-----------------SPDG-KLL--ASGSADGTVRL 230


                 ....*...
gi 134032030 824 YRVNRRAL 831
Cdd:COG2319  231 WDLATGKL 238
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 668-696 1.23e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.23e-05
                           10        20
                   ....*....|....*....|....*....
gi 134032030   668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
668-696 1.94e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.94e-05
                          10        20
                  ....*....|....*....|....*....
gi 134032030  668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 603-642 4.15e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 4.15e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 134032030   603 SWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWK 642
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
604-641 4.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 134032030  604 WKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLW 641
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
202-236 1.49e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 134032030  202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 202-236 1.81e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.81e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 134032030   202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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