|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
54-415 |
4.97e-38 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 143.63 E-value: 4.97e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 54 LNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKsvRLQGHEGPVCAVHAIYQSGpsegeqhaLIAS 132
Cdd:cd00200 5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAASADGT--------YLAS 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 133 AASDSTVRIWSKKGSEVkyLQTLSFRDGFVLsvCLAILPgtNVPVLACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRG 212
Cdd:cd00200 69 GSSDKTIRLWDLETGEC--VRTLTGHTSYVS--SVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 213 VEWATFGRdlFLASCSQDCLIRIWRLymkpasfetKDGSLRlkentftikdggvrttvavtleTVLAGHENWVNAVHWQP 292
Cdd:cd00200 141 VAFSPDGT--FVASSSQDGTIKLWDL---------RTGKCV----------------------ATLTGHTGEVNSVAFSP 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 293 sfykDGVlqqpvRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTV 372
Cdd:cd00200 188 ----DGE-----KLLSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 134032030 373 NPRQwapeiVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLFA 415
Cdd:cd00200 252 ECVQ-----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
21-413 |
1.18e-31 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 128.11 E-value: 1.18e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 21 ALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLK 99
Cdd:COG2319 83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPDGKtLASGSADGTVRLWDLATGKLLR 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 100 SvrLQGHEGPVCAVhAIyqSGPSEgeqhaLIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILP-GTnvpVL 178
Cdd:COG2319 157 T--LTGHSGAVTSV-AF--SPDGK-----LLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSV--AFSPdGK---LL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 179 ACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetkdgslrlkent 258
Cdd:COG2319 220 ASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGR--LLASGSADGTVRLWDL-------------------- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 259 ftikDGGvrttvavTLETVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWAPDEESgvwleqvRVGEVGG 338
Cdd:COG2319 276 ----ATG-------ELLRTLTGHSGGVNSVAFSP----DGK-----LLASGSDDGTVRLWDLATGK-------LLRTLTG 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134032030 339 NTLGFYDCQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRL 413
Cdd:COG2319 329 HTGAVRSVAFSPDGKTLASGSDDGTVRLW-----DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
266-696 |
4.29e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 102.68 E-value: 4.29e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 266 VRTTVAVTLETVLAGHENWVNAVHWQPSfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYD 345
Cdd:COG2319 62 LLDAAAGALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 346 CQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLfapWKKKDQKdr 425
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLATGK-- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 426 sqvtwhEIARPQIHGYNIKCLAMI-DRFQFVSGADEKVLRVFSAPRNFVenfsvisRQSLSHmlcddqdlpEGATVPALG 504
Cdd:COG2319 196 ------LLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKL-------LRTLTG---------HSGSVRSVA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 505 LSNkalfQGDIAsqpfeedelispAFGSpqvtfqpavlnepptEDHLLQntLW-----PEIQKLYGHGYEIVCVACNNSK 579
Cdd:COG2319 254 FSP----DGRLL------------ASGS---------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 580 TLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWKRQDATssefdpffSLFA 659
Cdd:COG2319 301 KLLASGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--------LLRT 367
|
410 420 430
....*....|....*....|....*....|....*..
gi 134032030 660 FTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:COG2319 368 LTG-----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
559-825 |
3.66e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 82.77 E-value: 3.66e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 559 EIQKLYGHGYEIVCVACNNSKTLLASAckasqKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 638
Cdd:cd00200 85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 639 SLWkrqDATSSEFDPFFSLfaftnkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSSHNPMEHPirpcs 714
Cdd:cd00200 160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWdlstGKCLGTLRGHENG----- 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 715 sildvgssVTAVSVCPvlnpaQRYIVAIGLESGKICIYswnktnqeinDWTSCVETNPSQSHSLGIRRLCWkscsddddd 794
Cdd:cd00200 222 --------VNSVAFSP-----DGYLLASGSEDGTIRVW----------DLRTGECVQTLSGHTNSVTSLAW--------- 269
|
250 260 270
....*....|....*....|....*....|.
gi 134032030 795 dddddteqSEEGPewlHFASCGEDHTVKIYR 825
Cdd:cd00200 270 --------SPDGK---RLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
588-831 |
5.44e-10 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 62.24 E-value: 5.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 588 ASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqDATSSEFDPFFSLfaftnkitsv 667
Cdd:COG2319 52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksSHNPMEHPirpcssildvgSSVTAVSVcpvlNPAQRYIVAiG 743
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKL--LRTLTGHS-----------GAVTSVAF----SPDGKLLAS-G 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 744 LESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddddddddteqSEEGpEWLhfASCGEDHTVKI 823
Cdd:COG2319 181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF-----------------SPDG-KLL--ASGSADGTVRL 230
|
....*...
gi 134032030 824 YRVNRRAL 831
Cdd:COG2319 231 WDLATGKL 238
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
668-696 |
1.23e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 42.68 E-value: 1.23e-05
10 20
....*....|....*....|....*....
gi 134032030 668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:smart00320 11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
668-696 |
1.94e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 42.33 E-value: 1.94e-05
10 20
....*....|....*....|....*....
gi 134032030 668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:pfam00400 10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
202-236 |
1.49e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.94 E-value: 1.49e-03
10 20 30
....*....|....*....|....*....|....*
gi 134032030 202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:pfam00400 6 TLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
202-236 |
1.81e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 1.81e-03
10 20 30
....*....|....*....|....*....|....*
gi 134032030 202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:smart00320 7 TLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLW 39
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
54-415 |
4.97e-38 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 143.63 E-value: 4.97e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 54 LNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKsvRLQGHEGPVCAVHAIYQSGpsegeqhaLIAS 132
Cdd:cd00200 5 LKGHTGGVTCVAF------SPDGKlLATGSGDGTIKVWDLETGELLR--TLKGHTGPVRDVAASADGT--------YLAS 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 133 AASDSTVRIWSKKGSEVkyLQTLSFRDGFVLsvCLAILPgtNVPVLACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRG 212
Cdd:cd00200 69 GSSDKTIRLWDLETGEC--VRTLTGHTSYVS--SVAFSP--DGRILSSSSRDKTIKVWDVETGKCLTTLR--GHTDWVNS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 213 VEWATFGRdlFLASCSQDCLIRIWRLymkpasfetKDGSLRlkentftikdggvrttvavtleTVLAGHENWVNAVHWQP 292
Cdd:cd00200 141 VAFSPDGT--FVASSSQDGTIKLWDL---------RTGKCV----------------------ATLTGHTGEVNSVAFSP 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 293 sfykDGVlqqpvRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYDCQFGENGTMIIAHAFHGALHLWKQSTV 372
Cdd:cd00200 188 ----DGE-----KLLSSSSDGTIKLW--DLSTGKCLGTLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG 251
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 134032030 373 NPRQwapeiVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLFA 415
Cdd:cd00200 252 ECVQ-----TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
21-413 |
1.18e-31 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 128.11 E-value: 1.18e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 21 ALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLK 99
Cdd:COG2319 83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPDGKtLASGSADGTVRLWDLATGKLLR 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 100 SvrLQGHEGPVCAVhAIyqSGPSEgeqhaLIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILP-GTnvpVL 178
Cdd:COG2319 157 T--LTGHSGAVTSV-AF--SPDGK-----LLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSV--AFSPdGK---LL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 179 ACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetkdgslrlkent 258
Cdd:COG2319 220 ASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGR--LLASGSADGTVRLWDL-------------------- 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 259 ftikDGGvrttvavTLETVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWAPDEESgvwleqvRVGEVGG 338
Cdd:COG2319 276 ----ATG-------ELLRTLTGHSGGVNSVAFSP----DGK-----LLASGSDDGTVRLWDLATGK-------LLRTLTG 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 134032030 339 NTLGFYDCQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRL 413
Cdd:COG2319 329 HTGAVRSVAFSPDGKTLASGSDDGTVRLW-----DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
42-319 |
4.01e-28 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 115.12 E-value: 4.01e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 42 LYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNELVSGGS-DNRVIHWELENNQVLKSvrLQGHEGPVCAVhAIYQSG 120
Cdd:cd00200 77 LWDLETGECVRTLTGHTSYVSSVAF------SPDGRILSSSSrDKTIKVWDVETGKCLTT--LRGHTDWVNSV-AFSPDG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 121 PsegeqhaLIASAASDSTVRIWSKKGSevKYLQTLSFRDGFVLSVCLAilpGTNVPVLACGDDDCrIHLYIQQDDQFQKa 200
Cdd:cd00200 148 T-------FVASSSQDGTIKLWDLRTG--KCVATLTGHTGEVNSVAFS---PDGEKLLSSSSDGT-IKLWDLSTGKCLG- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 201 lSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLYMKpasfetkdgslrlkentftikdggvrttvavTLETVLAG 280
Cdd:cd00200 214 -TLRGHENGVNSVAFSPDGY--LLASGSEDGTIRVWDLRTG-------------------------------ECVQTLSG 259
|
250 260 270
....*....|....*....|....*....|....*....
gi 134032030 281 HENWVNAVHWQPSfykdgvlqqPVRLLSASMDKTMILWA 319
Cdd:cd00200 260 HTNSVTSLAWSPD---------GKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
266-696 |
4.29e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 102.68 E-value: 4.29e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 266 VRTTVAVTLETVLAGHENWVNAVHWQPSfykdgvlqqPVRLLSASMDKTMILWapDEESGVWLEQVRvgevgGNTLGFYD 345
Cdd:COG2319 62 LLDAAAGALLATLLGHTAAVLSVAFSPD---------GRLLASASADGTVRLW--DLATGLLLRTLT-----GHTGAVRS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 346 CQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLfapWKKKDQKdr 425
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLW-----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL---WDLATGK-- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 426 sqvtwhEIARPQIHGYNIKCLAMI-DRFQFVSGADEKVLRVFSAPRNFVenfsvisRQSLSHmlcddqdlpEGATVPALG 504
Cdd:COG2319 196 ------LLRTLTGHTGAVRSVAFSpDGKLLASGSADGTVRLWDLATGKL-------LRTLTG---------HSGSVRSVA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 505 LSNkalfQGDIAsqpfeedelispAFGSpqvtfqpavlnepptEDHLLQntLW-----PEIQKLYGHGYEIVCVACNNSK 579
Cdd:COG2319 254 FSP----DGRLL------------ASGS---------------ADGTVR--LWdlatgELLRTLTGHSGGVNSVAFSPDG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 580 TLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWKRQDATssefdpffSLFA 659
Cdd:COG2319 301 KLLASGS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--------LLRT 367
|
410 420 430
....*....|....*....|....*....|....*..
gi 134032030 660 FTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:COG2319 368 LTG-----HTGAVTSVAFSPDGRTLASGSADGTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
28-237 |
2.39e-22 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 98.18 E-value: 2.39e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 28 PGGLLAFGTS--CSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNELVSGGSDNRVIH-WELENNQVLKsvRLQ 104
Cdd:cd00200 103 PDGRILSSSSrdKTIKVWDVETGKCLTTLRGHTDWVNSVAF------SPDGTFVASSSQDGTIKlWDLRTGKCVA--TLT 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 105 GHEGPVCAVhAIYQSGPSegeqhalIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILPGTNvpVLACGDDD 184
Cdd:cd00200 175 GHTGEVNSV-AFSPDGEK-------LLSSSSDGTIKLWDLSTGKC--LGTLRGHENGVNSV--AFSPDGY--LLASGSED 240
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 134032030 185 CRIHLYiqQDDQFQKALSLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWR 237
Cdd:cd00200 241 GTIRVW--DLRTGECVQTLSGHTNSVTSLAWSPDGK--RLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
73-468 |
1.12e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 98.44 E-value: 1.12e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 73 SPSNELVSGGSDNRVIHWELENNQVLKsvRLQGHEGPVCAVHAIYQSGpsegeqhaLIASAASDSTVRIWSKKGSEVkyL 152
Cdd:COG2319 46 PDGARLAAGAGDLTLLLLDAAAGALLA--TLLGHTAAVLSVAFSPDGR--------LLASASADGTVRLWDLATGLL--L 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 153 QTLSFRDGFVLSVclAILP-GTnvpVLACGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDC 231
Cdd:COG2319 114 RTLTGHTGAVRSV--AFSPdGK---TLASGSADGTVRLWDLATGKLLRTLT--GHSGAVTSVAFSPDGK--LLASGSDDG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 232 LIRIWRLymkpasfetkdgslrlkentftiKDGGVRTTvavtletvLAGHENWVNAVHWQPsfykDGvlQqpvRLLSASM 311
Cdd:COG2319 185 TVRLWDL-----------------------ATGKLLRT--------LTGHTGAVRSVAFSP----DG--K---LLASGSA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 312 DKTMILWapDEESGvwleqVRVGEVGGNTLGFYDCQFGENGTMIIAHAFHGALHLWkqstvNPRQWAPEIVISGHFDGVQ 391
Cdd:COG2319 225 DGTVRLW--DLATG-----KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW-----DLATGELLRTLTGHSGGVN 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 134032030 392 DLMWDPEGEFIITTSTDQTTRLFapwkkkdqkDRSqvTWHEIARPQIHGYNIKCLAMI-DRFQFVSGADEKVLRVFSA 468
Cdd:COG2319 293 SVAFSPDGKLLASGSDDGTVRLW---------DLA--TGKLLRTLTGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDL 359
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
29-238 |
4.55e-21 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 96.52 E-value: 4.55e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 29 GGLLAFGTS-CSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNE-LVSGGSDNRVIHWELENNQVLKsvRLQGH 106
Cdd:COG2319 216 GKLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAF------SPDGRlLASGSADGTVRLWDLATGELLR--TLTGH 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 107 EGPVCAVhAIYQSGpsegeqhALIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILPGTNVpvLACGDDDCR 186
Cdd:COG2319 288 SGGVNSV-AFSPDG-------KLLASGSDDGTVRLWDLATGKL--LRTLTGHTGAVRSV--AFSPDGKT--LASGSDDGT 353
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 134032030 187 IHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRL 238
Cdd:COG2319 354 VRLWDLATGELLRTLT--GHTGAVTSVAFSPDGR--TLASGSADGTVRLWDL 401
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
21-645 |
1.92e-20 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 94.59 E-value: 1.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 21 ALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWIrtedgSPSNELVSGGSDNRVIHWELENNQVLks 100
Cdd:COG2319 41 SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-----PDGRLLASASADGTVRLWDLATGLLL-- 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 101 VRLQGHEGPVCAVhAIYQSGpsegeqhALIASAASDSTVRIWSKKGSEVkyLQTLSFRDGFVLSVclAILP-GTnvpVLA 179
Cdd:COG2319 114 RTLTGHTGAVRSV-AFSPDG-------KTLASGSADGTVRLWDLATGKL--LRTLTGHSGAVTSV--AFSPdGK---LLA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 180 CGDDDCRIHLYIQQDDQFQKALSlcGHEDWIRGVEWATFGRdlFLASCSQDCLIRIWRLymkpasfetkdgslrlkentf 259
Cdd:COG2319 179 SGSDDGTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPDGK--LLASGSADGTVRLWDL--------------------- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 260 tikDGGvrttvavTLETVLAGHENWVNAVHWQPsfykDGVlqqpvRLLSASMDKTMILWapdeesgvwleqvrvgevggn 339
Cdd:COG2319 234 ---ATG-------KLLRTLTGHSGSVRSVAFSP----DGR-----LLASGSADGTVRLW--------------------- 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 340 tlgfydcqfgengtmiiahafhgalhlwkqstvNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLFapwkk 419
Cdd:COG2319 274 ---------------------------------DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW----- 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 420 kdqkdrsqvtwheiarpqihgynikclamidrfqfvsgadekvlrvfsaprnfvenfsvisrqslshmlcddqDLPEGAt 499
Cdd:COG2319 316 -------------------------------------------------------------------------DLATGK- 321
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 500 vpalglsnkalfqgdiasqpfeedelispafgspqvtfqpavlnepptedhllqntlwpEIQKLYGHGYEIVCVACNNSK 579
Cdd:COG2319 322 -----------------------------------------------------------LLRTLTGHTGAVRSVAFSPDG 342
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 134032030 580 TLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWKRQD 645
Cdd:COG2319 343 KTLASGS-----DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
556-827 |
1.33e-17 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 86.12 E-value: 1.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 556 LW-----PEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLL 630
Cdd:COG2319 188 LWdlatgKLLRTLTGHTGAVRSVAFSPDGKLLASGS-----ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 631 AVSRDRTWSLWkrqDATSSEFDPFFslfaftnkitSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSSHNPM 706
Cdd:COG2319 263 SGSADGTVRLW---DLATGELLRTL----------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWdlatGKLLRTLTGH 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 707 EHPIRpcssildvgsSVtAVSvcpvlnPAQRYIVAiGLESGKICIysWNKTNQEindwtscvETNPSQSHSLGIRRLCWk 786
Cdd:COG2319 330 TGAVR----------SV-AFS------PDGKTLAS-GSDDGTVRL--WDLATGE--------LLRTLTGHTGAVTSVAF- 380
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 134032030 787 scsddddddddddteqSEEGPewlHFASCGEDHTVKIYRVN 827
Cdd:COG2319 381 ----------------SPDGR---TLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
556-831 |
2.85e-17 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 84.96 E-value: 2.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 556 LW-----PEIQKLYGHGYEIVCVACNNSKTLLASACKASQkehaaIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLL 630
Cdd:COG2319 146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT-----VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 631 AVSRDRTWSLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSShnpM 706
Cdd:COG2319 221 SGSADGTVRLW---DLATGKL-----LRTLTG-----HSGSVRSVAFSPDGRLLASGSADGTVRLWdlatGELLRT---L 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 707 EHPirpcssildvGSSVTAVSVCPvlnpaQRYIVAIGLESGKICIYSWnKTNQEINDWTScvetnpsqsHSLGIRRLCWk 786
Cdd:COG2319 285 TGH----------SGGVNSVAFSP-----DGKLLASGSDDGTVRLWDL-ATGKLLRTLTG---------HTGAVRSVAF- 338
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 134032030 787 scsddddddddddteqSEEGpEWLhfASCGEDHTVKIYRVNRRAL 831
Cdd:COG2319 339 ----------------SPDG-KTL--ASGSDDGTVRLWDLATGEL 364
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
559-825 |
3.66e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 82.77 E-value: 3.66e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 559 EIQKLYGHGYEIVCVACNNSKTLLASAckasqKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 638
Cdd:cd00200 85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 639 SLWkrqDATSSEFDPFFSLfaftnkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSSHNPMEHPirpcs 714
Cdd:cd00200 160 KLW---DLRTGKCVATLTG----------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWdlstGKCLGTLRGHENG----- 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 715 sildvgssVTAVSVCPvlnpaQRYIVAIGLESGKICIYswnktnqeinDWTSCVETNPSQSHSLGIRRLCWkscsddddd 794
Cdd:cd00200 222 --------VNSVAFSP-----DGYLLASGSEDGTIRVW----------DLRTGECVQTLSGHTNSVTSLAW--------- 269
|
250 260 270
....*....|....*....|....*....|.
gi 134032030 795 dddddteqSEEGPewlHFASCGEDHTVKIYR 825
Cdd:cd00200 270 --------SPDGK---RLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
559-831 |
3.87e-17 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 84.58 E-value: 3.87e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 559 EIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 638
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGS-----ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 639 SLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECKSshnPMEHPirpcs 714
Cdd:COG2319 187 RLW---DLATGKL-----LRTLTG-----HTGAVRSVAFSPDGKLLASGSADGTVRLWdlatGKLLR---TLTGH----- 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 715 sildvGSSVTAVSVCPvlnpaQRYIVAIGLESGKICIYSWNkTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddd 794
Cdd:COG2319 246 -----SGSVRSVAFSP-----DGRLLASGSADGTVRLWDLA-TGELLRTLT---------GHSGGVNSVAF--------- 296
|
250 260 270
....*....|....*....|....*....|....*..
gi 134032030 795 dddddteqSEEGpEWLhfASCGEDHTVKIYRVNRRAL 831
Cdd:COG2319 297 --------SPDG-KLL--ASGSDDGTVRLWDLATGKL 322
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
274-696 |
2.35e-16 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 80.46 E-value: 2.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 274 LETVLAGHENWVNAVHWQPsfykdgvlqQPVRLLSASMDKTMILWapDEESGvwlEQVRVGEvgGNTLGFYDCQFGENGT 353
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSP---------DGKLLATGSGDGTIKVW--DLETG---ELLRTLK--GHTGPVRDVAASADGT 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 354 MIIAHAFHGALHLWKQSTVNPRQwapeiVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLfapwkkkdqkdrsqvtWHEI 433
Cdd:cd00200 65 YLASGSSDKTIRLWDLETGECVR-----TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKV----------------WDVE 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 434 ARPQI-----HGYNIKCLAMIDRFQFVSGA-DEKVLRVFsaprnfvenfsvisrqslshmlcddqdlpegatvpalglsn 507
Cdd:cd00200 124 TGKCLttlrgHTDWVNSVAFSPDGTFVASSsQDGTIKLW----------------------------------------- 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 508 kalfqgDIASqpfeedelispafgspqvtfqpavlnepptedhllqntlWPEIQKLYGHGYEIVCVACNNSKTLLASACK 587
Cdd:cd00200 163 ------DLRT---------------------------------------GKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 588 ASQkehaaIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRT---WSLWKRQdatssefdpffslfafTNKI 664
Cdd:cd00200 198 DGT-----IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTirvWDLRTGE----------------CVQT 256
|
410 420 430
....*....|....*....|....*....|..
gi 134032030 665 TSVHSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:cd00200 257 LSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
559-824 |
9.85e-16 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 78.53 E-value: 9.85e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 559 EIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTW 638
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGS-----GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 639 SLWKRQdatssefdpffslfafTNKITSV---HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksshnpmehpir 711
Cdd:cd00200 76 RLWDLE----------------TGECVRTltgHTSYVSSVAFSPDGRILSSSSRDKTIKVWdvetGKC------------ 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 712 pCSSILDVGSSVTAVSVcpvlNPAQRYIVAIGLESgkiCIYSWNKTNQeindwtSCVETNPsqSHSLGIRRLCWKscsdd 791
Cdd:cd00200 128 -LTTLRGHTDWVNSVAF----SPDGTFVASSSQDG---TIKLWDLRTG------KCVATLT--GHTGEVNSVAFS----- 186
|
250 260 270
....*....|....*....|....*....|...
gi 134032030 792 ddddddddteqseegPEWLHFASCGEDHTVKIY 824
Cdd:cd00200 187 ---------------PDGEKLLSSSSDGTIKLW 204
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
551-831 |
1.09e-13 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 73.79 E-value: 1.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 551 LLQNTLWPEIQKLYGHGYEIVCVACNNSKTLLASACkasqkEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLL 630
Cdd:COG2319 62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-----ADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLA 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 631 AVSRDRTWSLWkrqDATSSEFdpffsLFAFTNkitsvHSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksshnpm 706
Cdd:COG2319 137 SGSADGTVRLW---DLATGKL-----LRTLTG-----HSGAVTSVAFSPDGKLLASGSDDGTVRLWdlatGKL------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 707 ehpIRpcsSILDVGSSVTAVSVcpvlNPAQRYIvAIGLESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWk 786
Cdd:COG2319 197 ---LR---TLTGHTGAVRSVAF----SPDGKLL-ASGSADGTVRLWDL-ATGKLLRTLT---------GHSGSVRSVAF- 254
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 134032030 787 scsddddddddddteqSEEGPewlHFASCGEDHTVKIYRVNRRAL 831
Cdd:COG2319 255 ----------------SPDGR---LLASGSADGTVRLWDLATGEL 280
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
21-143 |
5.61e-11 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 64.28 E-value: 5.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 21 ALSWNTGPGGLLAFGTSCSVVLYDPQKKVVITNLNGHTARVNCLQWirtedgSPSNELVSGGSDNRVIH-WELENNQVLK 99
Cdd:cd00200 182 SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF------SPDGYLLASGSEDGTIRvWDLRTGECVQ 255
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 134032030 100 SvrLQGHEGPVCAVhAIYQSGPsegeqhaLIASAASDSTVRIWS 143
Cdd:cd00200 256 T--LSGHTNSVTSL-AWSPDGK-------RLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
588-831 |
5.44e-10 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 62.24 E-value: 5.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 588 ASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWkrqDATSSEFDPFFSLfaftnkitsv 667
Cdd:COG2319 52 AAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTG---------- 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW----GECksSHNPMEHPirpcssildvgSSVTAVSVcpvlNPAQRYIVAiG 743
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWdlatGKL--LRTLTGHS-----------GAVTSVAF----SPDGKLLAS-G 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 134032030 744 LESGKICIYSWnKTNQEINDWTscvetnpsqSHSLGIRRLCWkscsddddddddddteqSEEGpEWLhfASCGEDHTVKI 823
Cdd:COG2319 181 SDDGTVRLWDL-ATGKLLRTLT---------GHTGAVRSVAF-----------------SPDG-KLL--ASGSADGTVRL 230
|
....*...
gi 134032030 824 YRVNRRAL 831
Cdd:COG2319 231 WDLATGKL 238
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
668-696 |
1.23e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 42.68 E-value: 1.23e-05
10 20
....*....|....*....|....*....
gi 134032030 668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:smart00320 11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
668-696 |
1.94e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 42.33 E-value: 1.94e-05
10 20
....*....|....*....|....*....
gi 134032030 668 HSRIIWSCDWSPDNKYFFTGSRDKKVVVW 696
Cdd:pfam00400 10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
603-642 |
4.15e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 41.14 E-value: 4.15e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 134032030 603 SWKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLWK 642
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
604-641 |
4.37e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.48 E-value: 4.37e-04
10 20 30
....*....|....*....|....*....|....*...
gi 134032030 604 WKQVQSLAFHTLTVTQMTFSPDDKFLLAVSRDRTWSLW 641
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
202-236 |
1.49e-03 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 36.94 E-value: 1.49e-03
10 20 30
....*....|....*....|....*....|....*
gi 134032030 202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:pfam00400 6 TLEGHTGSVTSLAFSPDGK--LLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
202-236 |
1.81e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 1.81e-03
10 20 30
....*....|....*....|....*....|....*
gi 134032030 202 SLCGHEDWIRGVEWATFGRdlFLASCSQDCLIRIW 236
Cdd:smart00320 7 TLKGHTGPVTSVAFSPDGK--YLASGSDDGTIKLW 39
|
|
|